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    Strongyloid Hyperinfection in a Patient with Immunocompromised Chronic Kidney Disease.
    Indian J Nephrol 2017 Sep-Oct;27(5):389-391
    Department of Nephrology, Care Hospitals, Hyderabad, Telangana, India.
    Strongyloid hyperinfection is seen in immunocompromised individuals with underlying lung disease. The use of immunosuppressive drugs is an important risk factor. We report a case of IgA nephropathy with crescent, started on glucocorticoid and mycophenolate mofetil. Read More

    Prevention and assessment of infectious diseases among children and adult migrants arriving to the European Union/European Economic Association: a protocol for a suite of systematic reviews for public health and health systems.
    BMJ Open 2017 Sep 11;7(9):e014608. Epub 2017 Sep 11.
    Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
    Introduction: The European Centre for Disease Prevention and Control is developing evidence-based guidance for voluntary screening, treatment and vaccine prevention of infectious diseases for newly arriving migrants to the European Union/European Economic Area. The objective of this systematic review protocol is to guide the identification, appraisal and synthesis of the best available evidence on prevention and assessment of the following priority infectious diseases: tuberculosis, HIV, hepatitis B, hepatitis C, measles, mumps, rubella, diphtheria, tetanus, pertussis, poliomyelitis (polio), Haemophilus influenza disease, strongyloidiasis and schistosomiasis.

    Methods And Analysis: The search strategy will identify evidence from existing systematic reviews and then update the effectiveness and cost-effectiveness evidence using prospective trials, economic evaluations and/or recently published systematic reviews. Read More

    Colorectal Cancer Associated with Strongyloides stercoralis Colitis.
    ACG Case Rep J 2017 30;4:e104. Epub 2017 Aug 30.
    Department of Pathology, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, Elmhurst, NY.
    Strongyloides stercoralis colitis is a severe but easily curable disease with a high mortality rate if left untreated. Strongyloidiasis can persist up to several decades and may lead to a chronic colitis similar to that seen in inflammatory bowel disease (IBD), and the two are often confused. Chronic colitis from IBD is associated with an increased risk of colorectal cancer, so it is plausible that chronic colitis from strongyloidiasis may carry a similar risk. Read More

    Strongyloides stercoralis infection increases the likelihood to detect Trypanosoma cruzi DNA in peripheral blood in Chagas disease patients.
    Trop Med Int Health 2017 Sep 4. Epub 2017 Sep 4.
    Department of Infectious Diseases, Vall d'Hebron University Hospital, Barcelona, Spain.
    Objectives: In a previous study performed by our group, S. stercoralis infection in Chagas disease patients was associated with higher proportion of Trypanosoma cruzi DNA detection in peripheral blood. The aim of the study was to confirm this association in a larger cohort of patients. Read More

    The changing aetiology of eosinophilia in migrants and returning travellers in the Hospital for Tropical Diseases, London 2002-2015: An observational study.
    J Infect 2017 Oct 24;75(4):301-308. Epub 2017 Aug 24.
    Infectious Diseases and Tropical Medicine, Hospital for Tropical Diseases, University College London Hospitals NHS Trust, UK. Electronic address:
    Introduction: Determining the cause of eosinophilia in patients returning from the tropics continues to present a diagnostic challenge. The history, symptoms and degree of eosinophilia are often poor predictors of eventual diagnosis, but helminths are an important cause. The current British Infection Association recommendations use travel history to guide investigation of eosinophilia. Read More

    Different but overlapping populations of Strongyloides stercoralis in dogs and humans-Dogs as a possible source for zoonotic strongyloidiasis.
    PLoS Negl Trop Dis 2017 Aug 9;11(8):e0005752. Epub 2017 Aug 9.
    Department of Evolutionary Biology, Max-Planck-Institute for Developmental Biology, Tübingen, Germany.
    Strongyloidiasis is a much-neglected soil born helminthiasis caused by the nematode Strongyloides stercoralis. Human derived S. stercoralis can be maintained in dogs in the laboratory and this parasite has been reported to also occur in dogs in the wild. Read More

    Control of chronic Strongyloides stercoralis infection in an endemic community may be possible by pharmacological means alone: Results of a three-year cohort study.
    PLoS Negl Trop Dis 2017 Jul 31;11(7):e0005825. Epub 2017 Jul 31.
    Public Health Medicine, Centre for Chronic Disease Prevention, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University Cairns, Smithfield, Australia.
    Objectives: To assess the effect of treatment with ivermectin on the prevalence of S. stercoralis infection in an Australian Aboriginal population over a three year period, and to assess the validity of using a lower ELISA cut-off in diagnosis.

    Methods: A three-year cohort study of 259 adult Australian Aboriginals living in a remote community in northern Australia. Read More

    Evidence-Based Guidelines for Screening and Management of Strongyloidiasis in Non-Endemic Countries.
    Am J Trop Med Hyg 2017 Jul 24. Epub 2017 Jul 24.
    Barcelona Institute for Global Health (ISGlobal-CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
    Strongyloidiasis is an intestinal parasitic infection becoming increasingly important outside endemic areas, not only because of the high prevalence found in migrant populations, but also because immunosuppressed patients may suffer a potentially fatal disseminated disease. The aim of these guidelines is to provide evidence-based guidance for screening and treatment of strongyloidiasis in non-endemic areas. A panel of experts focused on three main clinical questions (who should be screened and how, how to treat), and reviewed pertinent literature available in international databases of medical literature and in documents released by relevant organizations/societies. Read More

    A Case of Strongyloidiasis: An Immigrant Healthcare Worker Presenting with Fatigue and Weight Loss.
    Case Rep Infect Dis 2017 28;2017:6718284. Epub 2017 Jun 28.
    Kingsbrook Jewish Medical Center, Brooklyn, NY, USA.
    Background: Strongyloides stercoralis is an intestinal nematode parasite classified as a soil-transmitted helminth, endemic in tropical and subtropical regions. Strongyloides stercoralis can remain dormant for decades after the initial infection.

    Case: We describe a patient who was diagnosed with Strongyloides stercoralis infection three weeks after a left inguinal hernia repair and discuss approaches to prevention, diagnosis, and treatment. Read More

    [Duodenal Linphoma asociated to Strongyloides stercoralis infection. Two types of HTLV-1 infection].
    Rev Gastroenterol Peru 2017 Apr-Jun;37(2):169-172
    Hospital Nacional Cayetano Heredia. Lima, Perú; Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia. Lima, Perú.
    Infection by the Human T- Lymphotropic virus I (HTLV-1) causes Adult T cell Leukemia-lymphoma (ATLL), being the duodenal involvement rare. Commonly, patients co-infected with HTLV-1 and Strongyloides stercoralis are seen due to the lack of TH2 response found on these patients. We describe a 48-year- old woman, from the jungle of Peru, with a family history of HTLV-1 infection, who presented with a History of chronic diarrhea and weight loss. Read More

    Occurrence of strongyloidiasis in privately owned and sheltered dogs: clinical presentation and treatment outcome.
    Parasit Vectors 2017 Jul 20;10(1):345. Epub 2017 Jul 20.
    Department of Veterinary Medicine, University of Bari, 70010, Valenzano, Bari, Italy.
    Background: The increasing number of reports of human infections by Strongyloides stercoralis from a range of European countries over the last 20 years has spurred the interest of the scientific community towards this parasite and, in particular, towards the role that infections of canine hosts may play in the epidemiology of human disease. Data on the epidemiology of canine strongyloidiasis is currently limited, most likely because of the inherent limitations of current diagnostic methods.

    Methods: Faecal samples were collected directly from the rectal ampulla of 272 animals of varying age and both genders living in Apulia, southern Italy. Read More

    Case report of a computerized tomography sign in Strongyloides stercoralis infection.
    Int Med Case Rep J 2017 27;10:219-222. Epub 2017 Jun 27.
    Internal Medicine, Wake Forest Baptist Health, Winston Salem, NC, USA.
    This is a case of strongyloidiasis showing colon enhancement on a computerized tomography (CT) scan. The patient presented with chief complaints of diarrhea and abdominal pain. She gave a history of recent travel to El Salvador and her stool was positive for Strongyloides stercoralis. Read More

    Serologic Monitoring of Public Health Interventions against Strongyloides stercoralis.
    Am J Trop Med Hyg 2017 Jul;97(1):166-172
    Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
    Northwestern Argentina is endemic for soil-transmitted helminths, and annual deworming programs are carried out in prioritized areas. High prevalence of Strongyloides stercoralis was reported in this area; therefore, control programs including ivermectin are being evaluated. The NIE-enzyme linked immunosorbent assay (ELISA) was used for this purpose. Read More

    Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.
    Front Cell Infect Microbiol 2017 20;7:261. Epub 2017 Jun 20.
    Department of Veterinary Medicine, Institute of Immunology, Freie Universität BerlinBerlin, Germany.
    Infections by the soil-transmitted threadworm Strongyloides stercoralis affect 30-100 million people worldwide, predominantly in tropic and sub-tropic regions. Here we assessed the T helper cell phenotypes in threadworm-infected patients and experimental murine infections with focus on CD4(+) T cells co-expressing markers of Th2 and Th1 differentiation. We show that mice infected with the close relative S. Read More

    The severely under-recognized public health risk of strongyloidiasis in North American cities-A One Health approach.
    Zoonoses Public Health 2017 Jul 2. Epub 2017 Jul 2.
    Department of Botany, Academy of Natural Sciences, Philadelphia, PA, USA.
    Strongyloides and other soil-transmitted helminths represent a severely under-recognized zoonotic public health risk, especially in North American cities. They are present throughout North America, including in urban areas, causing morbidity and mortality in human and non-human animals. Epidemiological "masking" of strongyloidiasis due to overlapping symptoms with other systemic diseases, including allergies, and diagnostic limitations complicate our understanding of the epidemiological extent of this disease, and auto-infection allows long-term persistence of individual infections. Read More

    Novel Findings in HIV, Immune Reconstitution Disease and Strongyloides stercoralis Infection.
    Am J Med Sci 2017 Jun 26;353(6):593-596. Epub 2016 May 26.
    Department of Medicine, Division of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
    We report the successful treatment of an HIV-infected patient with progressive strongyloidiasis as a component of immune reconstitution disease and a review of the literature on this topic. In our experience, pre- and post-antiretroviral therapy intestinal biopsies support a novel mechanism of immune reconstitution disease to Strongyloides stercoralis. We conclude that extended, dual antihelminthic therapy and temporary discontinuation of antiretroviral therapy may be effective in similar patients. Read More

    Screening of immunocompromised patients at risk of strongyloidiasis in western Turkey using ELISA and real-time PCR.
    Turk J Med Sci 2017 Jun 12;47(3):897-901. Epub 2017 Jun 12.
    Department of Infectious Diseases, Medical School, Ege University, İzmir, Turkey.
    Background/aim: Strongyloides stercoralis causes life-threatening hyperinfection or disseminated strongyloidiasis in immunocompromised patients such as HIV-positive, organ transplantation, and cancer patients. This study investigated the presence of strongyloidiasis in immunocompromised patients for the first time in Turkey.

    Materials And Methods: Serum and stool samples were collected from 108 patients (25. Read More

    A clinical enigma of ongoing constrictive pericarditis.
    Clin Med (Lond) 2017 Jun;17(3):248-250
    East Sussex Healthcare NHS Trust, St Leonards-on-sea, UK.
    A 59-year-old lady presented with a 1-week history of orthopnoea, paroxysmal nocturnal dyspnoea, night sweats and a productive cough. She had no recent history of travel. Transthoracic echocardiogram revealed preserved left ventricular systolic function with abnormal pericardial thickening and restrictive left ventricular filling consistent with pericardial constriction. Read More

    Strongyloides stercoralis in solid organ transplantation: early diagnosis gets the worm.
    Curr Opin Organ Transplant 2017 Aug;22(4):336-344
    aDepartment of Surgery, Division of Surgical Critical Care bSherrie & Alan Conover Center for Liver Disease & Transplantation, Houston Methodist Hospital, Houston, Texas, USA.
    Purpose Of Review: Strongyloidiasis is a parasitic infection affecting millions of people worldwide. Complications of infection are strongly associated with alcoholism, immunosuppression, and organ transplantation. Delayed diagnosis results in hyperinfection syndrome and disseminated strongyloidiasis leading to mortality rates approaching 80%. Read More

    Viability of Strongyloides venezuelensis eggs and larvae in vermiculite containing the fungus Duddingtonia flagrans.
    Parasitol Res 2017 Jul 15;116(7):2047-2051. Epub 2017 May 15.
    Department of Parasitology, University of Vila Velha-ES, Vila Velha, ES, Brazil.
    Strongyloidiasis is the most clinically important disease among the infections caused by geohelminths, seeing that this parasite can cause autoinfection. The use of nematophagous fungi like Duddingtonia flagrans, that have predation action on eggs and infecciososas forms of helminths, emerges as an alternative method for environmental control. For this reason, analyzing the viability of larvae and eggs of Strongyloides venezuelensis and the action of Duddingtonia flagrans AC001 in vermiculite, as well as the action of the nematophagous fungi in different growth stages, is important to elaborate and define the best culture conditions that favor the activity of the fungus. Read More

    Strongyloides seroprevalence before and after an ivermectin mass drug administration in a remote Australian Aboriginal community.
    PLoS Negl Trop Dis 2017 May 15;11(5):e0005607. Epub 2017 May 15.
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
    Background: Strongyloides seroprevalence is hyper-endemic in many Australian Aboriginal and Torres Strait Islander communities, ranging from 35-60%. We report the impact on Strongyloides seroprevalence after two oral ivermectin mass drug administrations (MDAs) delivered 12 months apart in a remote Australian Aboriginal community.

    Methods: Utilizing a before and after study design, we measured Strongyloides seroprevalence through population census with sequential MDAs at baseline and month 12. Read More

    First molecular identification and genetic diversity of Strongyloides stercoralis and Strongyloides fuelleborni in human communities having contact with long-tailed macaques in Thailand.
    Parasitol Res 2017 Jul 12;116(7):1917-1923. Epub 2017 May 12.
    Research and Diagnostic Center for Emerging Infectious Diseases, Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
    The parasitic nematodes, Strongyloides stercoralis and Strongyloides fuelleborni, can infect humans and non-human primates. We amplified and sequenced a portion of the 18S ribosomal RNA gene (rRNA) and of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene of Strongyloides from humans in the study area in Thailand, where people have frequent contact with long-tailed macaques. Fresh stool samples were obtained from 213 people and were examined using the agar plate culture method. Read More

    Serological and molecular tests for the diagnosis of Strongyloides stercoralis infection in dogs.
    Parasitol Res 2017 Jul 10;116(7):2027-2029. Epub 2017 May 10.
    Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Via Sempreboni 5, 37024, Negrar, Verona, Italy.
    Strongyloides stercoralis can cause severe infection both in humans and dogs. Coproparasitological examination has low sensitivity for the diagnosis of this parasite; hence, different diagnostic techniques have been implemented. However, serology and molecular methods have been assessed almost exclusively in humans. Read More

    Twenty-five Years of Chronic Strongyloidiasis in an Immigrant.
    Clin Med Insights Case Rep 2017 8;10:1179547616684828. Epub 2017 Feb 8.
    Internal Medicine Residency, St. Elizabeth's Medical Center, Brighton, MA, USA.
    Chronic strongyloidiasis is an infection of the tropical regions, caused by the nematode Strongyloides stercoralis. In the United States, patients are typically immigrants. The very long asymptomatic phase followed by the clinical presentation of the disease mimics asthma, chronic obstructive pulmonary disease (COPD), or inflammatory bowel disease (IBD) as in this case report. Read More

    Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases.
    BMC Infect Dis 2017 May 2;17(1):320. Epub 2017 May 2.
    Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
    Background: Strongyloidiasis is a chronic parasitic infection caused by Strongyloides stercoralis. Severe cases such as, hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), can involve pulmonary manifestations. These manifestations frequently aid the diagnosis of strongyloidiasis. Read More

    Modulation of Mycobacterium tuberculosis-specific humoral immune responses is associated with Strongyloides stercoralis co-infection.
    PLoS Negl Trop Dis 2017 May 1;11(5):e0005569. Epub 2017 May 1.
    National Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India.
    Background / Objectives: Helminth infections are known to influence T cell responses in latent tuberculosis (LTBI). Whether helminth infections also modulate B cell responses in helminth-tuberculosis co-infection is not known.

    Methods: We assessed Mycobacterium tuberculosis (Mtb)-antigen specific IgM and IgG levels, circulating levels of the B cell growth factors, BAFF and APRIL and the absolute numbers of the various B cell subsets in individuals with LTBI, LTBI with coincident Strongyloides stercoralis (Ss) infection (LTBI/Ss) and in those with Ss infection alone (Ss). Read More

    Identification of antigenic proteins in Strongyloides stercoralis by proteomic analysis.
    Parasitol Res 2017 Jun 29;116(6):1687-1693. Epub 2017 Apr 29.
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
    Strongyloides stercoralis is an intestinal helminth that infects people worldwide. Hyperinfection or disseminated human strongyloidiasis can involve vital organs, leading to lethal outcomes. We analyzed immunoproteomics of antigenic spots, derived from S. Read More

    A Strong and Fortuitous Case of Dyspnea.
    J La State Med Soc 2017 Mar-Apr;169(2):51. Epub 2017 Apr 15.
    Department of Internal Medicine, Tulane Health Sciences Center in New Orleans, LA.
    Case: A 48 year-old man with no past medical history was sent to our emergency department (ED); from a primary care clinic for hypertensive urgency of 200/130. The man reported an intermittent non-productive cough of approximately one year's duration and worsening dyspnea on exertion and orthopnea over the last month with lower extremity swelling. Of note, he emigrated from Honduras twenty years ago. Read More

    [Clinical and epidemiological characteristics of strongyloidiasis in patients with comorbidities].
    Rev Chilena Infectol 2017 Feb;34(1):47-53
    Centro de Pesquisas Aggeu Magalhães, Departamento de Parasitología, Serviço de Referência Nacional em Filarioses, Fundação Oswaldo Cruz, Pernambuco, Brasil.
    The strongyloidiasis is a parasitic disease that poses as a serious public health problem, mainly in tropical and subtropical countries. Over the years, some conditions, such as advances in corticosteroid treatment and immunosuppressive diseases, have improved not only the increase in cases of strongyloidiasis, but also the emergence of severe forms of the disease and / or deaths. For these reasons, the objective of this study is to make a critical analysis of the occurrence of strongyloidiasis in patients with comorbidities, describing clinical and epidemiological characteristics associated with these diseases that can highlight the importance of monitoring this parasitosis in most susceptible groups. Read More

    In vitro efficacy of latex and purified papain from Carica papaya against Strongyloides venezuelensis eggs and larvae.
    Rev Inst Med Trop Sao Paulo 2017 Apr 3;59:e7. Epub 2017 Apr 3.
    Universidade Federal de Goiás, Laboratório de Parasitologia, Jataí, Goiás, Brazil.
    Latex from Carica papaya is rich in bioactive compounds, especially papain, which may help to control parasitic diseases. This study evaluated the efficacy of latex from C. papaya and purified papain against Strongyloides venezuelensis. Read More

    A case of Strongyloides hyperinfection syndrome in the setting of persistent eosinophilia but negative serology.
    Diagn Microbiol Infect Dis 2017 Jun 14;88(2):168-170. Epub 2017 Mar 14.
    Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, 1 Gustave Levy Place 1090, New York, NY, 10029.
    Strongyloides stercoralis is a unique intestinal nematode with the ability to replicate and complete its life cycle without leaving the host. We report a fatal case of Strongyloides hyperinfection syndrome in a patient who had persistent eosinophilia for several years but negative Strongyloides serology. Our case suggests that ELISA serologies cannot solely be relied upon to diagnose Strongyloides stercoralis infection; history and clinical judgment remain crucial to this diagnosis. Read More

    Enterococcal meningitis in association with Strongyloides hyperinfection syndrome.
    Germs 2017 Mar 1;7(1):28-31. Epub 2017 Mar 1.
    MD, FIDSA, Senior Consultant, Institute of Infectious Diseases, Apollo Hospitals, 2A Rajam Mansion, 4 Luz Ave 4th St, Chennai, 600004, Tamil Nadu, India.
    Introduction: Strongyloidiasis can cause hyperinfection or disseminated infection in an immunocompromised host, and is an important factor linked to enterococcal bacteremia and meningitis.

    Case Reports: We report two cases highlighting the importance of suspecting Strongyloides hyperinfection syndrome in patients with enterococcal meningitis.

    Conclusion: Our cases highlight the importance of suspecting Strongyloides hyperinfection syndrome in cases of community acquired enterococcal bacteremia and meningitis. Read More

    Strongyloides hyperinfection syndrome in an immunocompetent host resulting in bandemia and death.
    BMJ Case Rep 2017 Mar 22;2017. Epub 2017 Mar 22.
    Department of Medicine, George Washington University, Washington, DC, USA.
    Strongyloides stercoralis infection is usually asymptomatic but can result in a hyperinfection syndrome, most commonly triggered by acquired or iatrogenic immunosuppression. Here, we present a case of a man aged 60 years originally from a strongyloides endemic area with a medical history of alcohol abuse who presents with strongyloides hyperinfection syndrome (SHS) complicated by partial small bowel obstruction, pulmonary haemorrhage, large bandemia without eosinophilia and cardiac arrest resulting in death. This case is notable for the presence of bandemia and absence of eosinophilia, lack of historical risk factors for hyperinfection, specifically corticosteroid immunosuppressants, and dramatic decline in clinical status which ultimately resulted in the patient's death. Read More

    Building a global schistosomiasis alliance: an opportunity to join forces to fight inequality and rural poverty.
    Infect Dis Poverty 2017 Mar 23;6(1):65. Epub 2017 Mar 23.
    National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention, Shanghai, China.
    Schistosomiasis, one of the 17 neglected tropical diseases listed by the World Health Organization, presents a substantial public health and economic burden. Of the 261 million people requiring preventive chemotherapy for schistosomiasis in 2013, 92% of them lived in sub-Saharan Africa and only 12.7% received preventive chemotherapy. Read More

    Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4(+) T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis.
    Infect Immun 2017 May 21;85(5). Epub 2017 Apr 21.
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    There is evidence that mast cells, basophils, and IgE can contribute to immune responses to parasites; however, the relative levels of importance of these effector elements in parasite immunity are not fully understood. Previous work in Il3-deficient and c-kit mutant Kit(W/W-v) mice indicated that interleukin-3 and c-Kit contribute to expulsion of the intestinal nematode Strongyloides venezuelensis during primary infection. Our findings in mast cell-deficient Kit(W-sh/W-sh) mice and two types of mast cell-deficient mice that have normal c-kit ("Hello Kitty" and MasTRECK mice) confirmed prior work in Kit(W/W-v) mice that suggested that mast cells play an important role in S. Read More

    Seroprevalence of five neglected parasitic diseases among immigrants accessing five infectious and tropical diseases units in Italy: a cross-sectional study.
    Clin Microbiol Infect 2017 May 1;23(5):335.e1-335.e5. Epub 2017 Mar 1.
    Infectious Diseases Unit, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy.
    Objective: This multicentre cross-sectional study aims to estimate the prevalence of five neglected tropical diseases (Chagas disease, filariasis, schistosomiasis, strongyloidiasis and toxocariasis) among immigrants accessing health care facilities in five Italian cities (Bologna, Brescia, Florence, Rome, Verona).

    Methods: Individuals underwent a different set of serological tests, according to country of origin and presence of eosinophilia. Seropositive patients were treated and further followed up. Read More

    Syndrome of Inappropriate Anti-Diuretic Hormone Secretion Secondary to Strongyloides stercoralis Infection in an Allogeneic Stem Cell Transplant Patient: A Case Report and Literature Review.
    Transplant Proc 2017 Mar;49(2):373-377
    Adult Stem Cell Transplant Program, The University of Miami Miller School of Medicine & Sylvester Comprehensive Cancer Center, Miami, Florida, USA.
    Syndrome of inappropriate anti-diuretic hormone (SIADH) has been reported to be associated with systemic Strongyloides stercoralis. Here, we report a case of a stem cell transplant (SCT) recipient who developed severe SIADH secondary to systemic S Stercoralis. The SIADH resolved quickly after treating the systemic S Stercoralis with ivermectin. Read More

    Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research.
    J Parasitol Res 2017 22;2017:5056314. Epub 2017 Jan 22.
    Department of Animal Biology, Post-Graduation Program in Animal Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
    Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives. Read More

    The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial.
    PLoS Negl Trop Dis 2017 Feb 8;11(2):e0005213. Epub 2017 Feb 8.
    London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Background: Chronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. It has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial.

    Methodology/principal Findings: We used new data from the Entebbe Mother and Baby Study, a trial of anthelminthic treatment during pregnancy conducted in Uganda, to further investigate this hypothesis. Read More

    Prevalence of Strongyloides stercoralis and Other Intestinal Parasites among Institutionalized Mentally Disabled Individuals in Rasht, Northern Iran.
    Iran J Parasitol 2016 Oct-Dec;11(4):527-533
    Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Research Center for Fascioliasis and Parasitic Diseases, Guilan University of Medical Sciences, Rasht, Iran.
    Background: We aimed to determine the status of strongyloidiasis in mentally disabled population in the institutional places in Rasht City, the capital of Guilan Province, northern Iran.

    Methods: This cross-sectional study was conducted in 8 institutions for mentally retarded population in Rasht in 2013. Before collecting the samples, a questionnaire was filled out for each participant by an expert person. Read More

    Disseminated Strongyloidiasis in an Immunodeficient Patient (Pemphigus Vulgaris) Due to Corticosteroid Therapy: A Case Report.
    Iran J Parasitol 2016 Jul-Sep;11(3):411-416
    Dept. of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    Strongyloidiasis is a frequent misdiagnosed parasitic infection in the world that caused by Strongyloides stercoralis. In Iran, the disease is predominantly reported from warm and humid climate provinces. The patient was a 54-yr-old man, originated from Khuzestan Province with a history of pemphigus and diabetes that was treated with high-dose of corticosteroid drugs before admission in a non-private hospital in Shiraz, Iran in 2014. Read More

    Diagnosis of Strongyloides stercoralis by morphological characteristics combine with molecular biological methods.
    Parasitol Res 2017 Apr 26;116(4):1159-1163. Epub 2017 Jan 26.
    Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
    Strongyloidiasis is one of the neglected tropical diseases caused by infection with the nematode Strongyloides genus and distributed worldwide. Strongyloidiasis can be fatal in immunosuppressed patients induced hyperinfection or disseminated strongyloidiasis. Unfortunately, until now, due to the unspecific clinical symptom in infected individuals and the low sensitivity diagnosis of strongyloidiasis, many patients were misdiagnosed every year. Read More

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