Transrenal DNA-based diagnosis of Strongyloides stercoralis (Grassi, 1879) infection: Bayesian latent class modeling of test accuracy.
- Authors:
- Alejandro J Krolewiecki,
- Artemis Koukounari,
- Miryam Romano,
- Nicolas N Caro,
- Alan L Scott,
- Pedro Fleitas,
- Rubin Cimino,
- Clive J Shiff
PLoS Negl Trop Dis 2018 Jun 1;12(6):e0006550. Epub 2018 Jun 1.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
For epidemiological work with soil transmitted helminths the recommended diagnostic approaches are to examine fecal samples for microscopic evidence of the parasite. In addition to several logistical and processing issues, traditional diagnostic approaches have been shown to lack the sensitivity required to reliably identify patients harboring low-level infections such as those associated with effective mass drug intervention programs. In this context, there is a need to rethink the approaches used for helminth diagnostics. Read More
