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    1 OF 78

    Transrenal DNA-based diagnosis of Strongyloides stercoralis (Grassi, 1879) infection: Bayesian latent class modeling of test accuracy.
    PLoS Negl Trop Dis 2018 Jun 1;12(6):e0006550. Epub 2018 Jun 1.
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
    For epidemiological work with soil transmitted helminths the recommended diagnostic approaches are to examine fecal samples for microscopic evidence of the parasite. In addition to several logistical and processing issues, traditional diagnostic approaches have been shown to lack the sensitivity required to reliably identify patients harboring low-level infections such as those associated with effective mass drug intervention programs. In this context, there is a need to rethink the approaches used for helminth diagnostics. Read More

    Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011.
    PLoS One 2018 30;13(5):e0197770. Epub 2018 May 30.
    Department of Infectious Diseases, Public Health Service (GGD), Amsterdam, the Netherlands.
    Background: Despite the considerable burden of helminth infections in developing countries and increasing international travel, little is known about the risks of infection for travelers.

    Objective: We studied the attack and incidence rate of serology confirmed strongyloidiasis, filariasis, and toxocariasis among long-term travelers and associated factors. A second objective was to evaluate eosinophilia as a positive/negative predictive value (PPV/NPV) for a recent helminth infection. Read More

    ELISA based on a recombinant Paragonimus heterotremus protein for serodiagnosis of human paragonimiasis in Thailand.
    Parasit Vectors 2018 May 30;11(1):322. Epub 2018 May 30.
    Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
    Background: Paragonimus heterotremus is the main causative agent of paragonimiasis in Thailand. In Western blot diagnostic assays for paragonimiasis, the 35 kDa band present in crude P. heterotremus somatic extracts represents one of the known diagnostic bands. Read More

    , and infections in rural populations in central and southern Togo.
    Parasite Epidemiol Control 2018 May 13;3(2):77-87. Epub 2018 Mar 13.
    Institute for Tropical Medicine, University Clinics of Tübingen, Germany.
    Background: , and are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with regional mass drug administration (MDA). Epidemiological surveys are of importance to evaluate the geographical distribution of these helminth parasites and the diseases they may cause, however, up to date epidemiological evaluations on and in Togo are rare, and surveys on are important especially under the aspect of MDA of ivermectin which is performed since decades. Read More

    Evaluation of two prognostic indices for adult T-cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan.
    Cancer Sci 2018 May 17. Epub 2018 May 17.
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
    Aggressive adult T-cell leukemia/lymphoma (ATL) has an extremely poor prognosis and is hyperendemic in Okinawa, Japan. This study evaluated two prognostic indices (PIs) for aggressive ATL, the ATL-PI and Japan Clinical Oncology Group (JCOG)-PI, in a cohort from Okinawa. The PIs were originally developed using two different Japanese cohorts that included few patients from Okinawa. Read More

    Extended screening for infectious diseases among newly-arrived asylum seekers from Africa and Asia, Verona province, Italy, April 2014 to June 2015.
    Euro Surveill 2018 Apr;23(16)
    Centre for Tropical Diseases (CTD), Sacro Cuore Hospital, Negrar, Verona, Italy.
    Background and aimManagement of health issues presented by newly-arrived migrants is often limited to communicable diseases even though other health issues may be more prevalent. We report the results of infectious disease screening proposed to 462 recently-arrived asylum seekers over 14 years of age in Verona province between April 2014 and June 2015. Screening for latent tuberculosis (TB) was performed via tuberculin skin test (TST) and/or QuantiFERON-TB Gold in-tube assay and/or chest X-ray. Read More

    Molecular diagnosis of Strongyloides stercoralis among transplant candidates.
    Transpl Infect Dis 2018 Apr 20:e12909. Epub 2018 Apr 20.
    Laboratório de Investigação Médica (LIM/06 - Laboratório de Imunopatologia da Esquistossomose), Hospital das Clínicas da Faculdade de Medicina, USP, São Paulo, Brazil.
    Strongyloidiasis can occur without any symptoms or as a potentially fatal hyperinfection or disseminated infection, principally in immunosuppressed patients. Our study aimed to evaluate the application of conventional polymerase chain reaction (cPCR) and real-time PCR (qPCR). Polymerase chain reaction (PCR) and real-time PCR (qPCR) targeting the 18S rRNA gene for detection of Strongyloides stercoralis infection among transplant candidates were applied in stool samples obtained from 150 transplant candidates, preliminarily analyzed by parasitological methods. Read More

    Terminal ileum resection as a trigger for Strongyloides stercoralis hyperinfection and ensuing serial sepsis in a 37-year-old patient with complicated Crohn's disease: a case report.
    Z Gastroenterol 2018 04 11;56(4):380-383. Epub 2018 Apr 11.
    University Hospital Center Zagreb, Division of Gastroenterology and Hepatology, Zagreb, Croatia.
    The nematode Strongyloides stercoralis, outside the tropics and subtropics present in small endemic foci, can cause an infection after direct skin contact with contaminated soil containing infective filariform larvae and, rarely, after intimate interhuman contact or after transplantation of an infected solid organ. Following skin penetration, migration, and maturation through several stages, a small number of invasive filariform larvae can develop anew in the gut lumen, perpetuating new cycles of penetration, tissue migration, and reproduction, without leaving the host.In a state of immunosuppression, autoinfection can progress to life-threatening hyperinfection and/or infection disseminated through virtually any organ. Read More

    Parasite allergens.
    Mol Immunol 2018 Mar 24. Epub 2018 Mar 24.
    Institute for Immunological Research, University of Cartagena, Cartagena, Colombia.
    Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infections is intriguing that they are not usually associated with allergic symptoms, which probably (but not exclusively) depends on parasite-induced immunomodulation. However, allergic manifestations have been described during some helminth infections such as ascariasis, strongyloidiasis, anisakiasis and hydatidosis. Read More

    hyperinfection in an unconscious diabetic patient with dermatomyositis.
    Indian J Pathol Microbiol 2018 Jan-Mar;61(1):109-112
    Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    A case of Strongyloides stercoralis hyperinfection in a patient with dermatomyositis and diabetes mellitus is herein reported. The case was a 60-year-old female admitted due to watery diarrhea and unconsciousness. She had a 10-year history of chronic immunosuppressive therapy including methotrexate and prednisolone for dermatomyositis. Read More

    Molecular diagnosis of strongyloidiasis in a population of an endemic area through nested-PCR.
    Gastroenterol Hepatol Bed Bench 2018 ;11(1):68-74
    Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Aim: This study is aimed to diagnose and analyze strongyloidiasis in a population of an endemic area of Iran using nested-PCR, coupled with parasitological methods.

    Background: Screening of strongyloidiasis infected people using reliable diagnostic techniques are essential to decrease the mortality and morbidity associated with this infection. Molecular methods have been proved to be highly sensitive and specific for detection of in stool samples. Read More

    Opportunistic and non-opportunistic intestinal parasites in HIV/ AIDS patients in relation to their clinical and epidemiological status in a specialized medical service in Goiás, Brazil.
    Rev Inst Med Trop Sao Paulo 2018 Mar 8;60:e13. Epub 2018 Mar 8.
    Universidade Federal de Goiás, Laboratório de Parasitologia, Jataí, Goiás, Brazil.
    Patients infected with the Human Immunodeficiency Virus (HIV) often have opportunistic infections, among which strongyloidiasis and coccidiosis are the most common parasitic infections that aggravate their health status. This study examined the prevalence of intestinal parasites, particularly of Strongyloides stercoralis and intestinal coccidia in patients with the Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS) who were treated at the Specialized Assistance Service (SAE) of Jataí, State of Goiás, Brazil, and analyzed its correlation with clinical, laboratory, and socio-epidemiological parameters. A total of 270 stool samples were analyzed by the Lutz technique, Rugai's method, Agar Plate Culture, Ritchie's method and specific staining, Ziehl-Neelsen modified technique, Kinyoun's method and the rapid safranin method. Read More

    Organ donor screening practices for Strongyloides stercoralis infection among US organ procurement organizations.
    Transpl Infect Dis 2018 Jun 31;20(3):e12865. Epub 2018 Mar 31.
    Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Background: Targeted donor screening for strongyloidiasis performed at the time of organ procurement can prevent this life-threatening donor-derived infection.

    Method: The Association of Organ Procurement Organizations surveyed members to determine the number of US organ procurement organizations (OPOs) performing donor screening for Strongyloides infection and their screening practices.

    Results: All 58 OPOs responded to the survey. Read More

    Treatment of disseminated Strongyloides spp. infection in an infant Sumatran orangutan (Pongo abelii).
    J Med Primatol 2018 Jun 1;47(3):201-204. Epub 2018 Mar 1.
    Animal Health Department, Saint Louis Zoo, Saint Louis, MO, USA.
    Strongyloides nematodes have been reported in all species of great apes with orangutans ≤5 years old most susceptible to severe clinical disease. This brief communication describes the first published case of antemortem diagnosis and treatment of disseminated strongyloidiasis in a clinically affected 5-month-old Sumatran orangutan (Pongo abelii). Read More

    Management of severe strongyloidiasis attended at reference centers in Spain.
    PLoS Negl Trop Dis 2018 02 23;12(2):e0006272. Epub 2018 Feb 23.
    Infectious Diseases Department, Vall de Hebrón University Hospital, PROSICS, Barcelona, Spain.
    Introduction: Strongyloides stercoralis is a globally distributed nematode that causes diverse clinical symptoms in humans. Spain, once considered an endemic country, has experienced a recent increase in imported cases. The introduction of serology helps diagnosis and is currently replacing microbiological techniques in some settings, but its sensitivity is variable and can be low in immunocompromised patients. Read More

    Metaperiodate deglycosylation of Strongyloides venezuelensis larvae: Immunochemical characterization and antigen production for human strongyloidiasis diagnosis.
    Acta Trop 2018 Jun 15;182:27-33. Epub 2018 Feb 15.
    Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, 38400-902, Uberlândia, MG, Brazil. Electronic address:
    Strongyloidiasis is an important helminthiasis affecting million people worldwide. The aim of this study was to use sodium metaperiodate (MP) treatment to immunochemically characterize Strongyloides venezuelensis filariform larvae and use MP-treated heterologous antigen to detect IgG and subclasses in serum. Samples from individuals with definitive diagnosis of strongyloidiasis (n = 50), other parasitic diseases (n = 60) and negative endemic (n = 50) were tested. Read More

    Identification and Preliminary Evaluation of a Novel Recombinant Protein for Serodiagnosis of Strongyloidiasis.
    Am J Trop Med Hyg 2018 Apr 8;98(4):1165-1170. Epub 2018 Feb 8.
    Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia.
    is a human parasite that can cause a long-term infection. In immunosuppressed patients, strongyloidiasis may be fatal when there is overwhelming autoinfection resulting in the migration of large numbers of larvae through many organs. Definitive diagnosis is still a challenge, and a combination of symptoms, microscopic identification, and serology test results are often used to arrive at a clinical decision. Read More

    Accuracy of molecular biology techniques for the diagnosis of Strongyloides stercoralis infection-A systematic review and meta-analysis.
    PLoS Negl Trop Dis 2018 02 9;12(2):e0006229. Epub 2018 Feb 9.
    Centre for Tropical Diseases, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy.
    Background: Strongyloides stercoralis infection is a neglected tropical disease which can lead to severe symptoms and even death in immunosuppressed people. Unfortunately, its diagnosis is hampered by the lack of a gold standard, as the sensitivity of traditional parasitological tests (including microscopic examination of stool samples and coproculture) is low. Hence, alternative diagnostic methods, such as molecular biology techniques (mostly polymerase chain reaction, PCR) have been implemented. Read More

    High prevalence of S. Stercoralis infection among patients with Chagas disease: A retrospective case-control study.
    PLoS Negl Trop Dis 2018 01 31;12(1):e0006199. Epub 2018 Jan 31.
    International Health Department, ISGlobal, Barcelona Center for International Health Research, (CRESIB), Hospital Clínic-Universitat de Barcelona, Spain.
    Background: We evaluate the association between Trypanosoma cruzi infection and strongyloidiasis in a cohort of Latin American (LA) migrants screened for both infections in a non-endemic setting.

    Methodology: Case-control study including LA individuals who were systematically screened for T. cruzi infection and strongyloidiasis between January 2013 and April 2015. Read More

    Anemia, intractable vomiting, chronic diarrhea, and syndrome of inappropriate antidiuretic secretion: a diagnostic dilemma: Disseminated strongyloidosis in a patient with newly diagnosed HTLV infection-case report and review of literature.
    Medicine (Baltimore) 2017 Dec;96(52):e9229
    Department of Medicine.
    Rationale: Strongyloidiasis hyperinfection and disseminated disease have high mortality rates due to several complications and early detection of Strongyloides infection is therefore prudent.

    Patient Concerns: A 37-year-old male patient came with chronic diarrhea, intractable vomiting and was found to have hyponatremia, and anemia on the initial laboratory tests.

    Diagnoses: Further work up revealed syndrome of inappropriate antidiuretic secretion to be the cause of the hyponatremia in addition to gastrointestinal loses. Read More

    Recommendations for Management of Endemic Diseases and Travel Medicine in Solid-Organ Transplant Recipients and Donors: Latin America.
    Transplantation 2018 02;102(2):193-208
    Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, Madrid, Spain.
    The Recommendations for Management of Endemic Diseases and Travel Medicine in Solid-Organ Transplant Recipients and Donors: Latin America clinical practice guideline is intended to guide clinicians caring for solid-organ transplant (SOT) donors, candidates and recipients regarding infectious diseases (ID) issues related to this geographical region, mostly located in the tropics. These recommendations are based on both systematic reviews of relevant literature and expert opinion from both transplant ID and travel medicine specialists. The guidelines provide recommendations for risk evaluation and laboratory investigation, as well as management and prevention of infection of the most relevant endemic diseases of Latin America. Read More

    Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa.
    Infect Dis Poverty 2018 Jan 30;7(1). Epub 2018 Jan 30.
    Department of Parasitology-Mycology, Faculty of Medicine, University of Health Sciences, P.O. Box 4009, Libreville, Gabon.
    Background: Malaria, filariasis, and intestinal parasitic infections (IPIs) are common and frequently overlap in developing countries. The prevalence and predictors of these infections were investigated in three different settlements (rural, semi-urban, and urban) of Gabon.

    Methods: During cross-sectional surveys performed from September 2013 to June 2014, 451 individuals were interviewed. Read More

    Prevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in school children in Cubal, Western Angola.
    Parasit Vectors 2018 01 29;11(1):67. Epub 2018 Jan 29.
    Parasitology Reference and Research Laboratory, National Centre for Microbiology, Health Institute Carlos III, Ctra. Majadahonda-Pozuelo Km 2, 28220, Majadahonda, Madrid, Spain.
    Background: Human infections by the gastrointestinal helminth Strongyloides stercoralis and the enteric protozoans Giardia duodenalis, Cryptosporidium spp. and Blastocystis spp. are not formally included in the list of 20 neglected tropical diseases prioritised by the World Health Organization. Read More

    Severe Strongyloidiasis in Solid Organ Transplant Recipients: Should We Preventively Treat the Recipient, the Donor, or Both?
    Am J Trop Med Hyg 2018 Apr 18;98(4):941-944. Epub 2018 Jan 18.
    Département d'Urologie, Néphrologie et Transplantation, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière Charles Foix, Paris, France.
    Strongyloidiasis is caused by a soil-transmitted helminth that is endemic in tropical and subtropical countries. The parasite can complete its life cycle without leaving the host, allowing autoinfection and persistence. The risk of infection in travelers is low, but the disease may become lethal following immunosuppression. Read More

    Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up After Ivermectin Treatment.
    Clin Infect Dis 2018 May;66(10):1558-1565
    Facultad de Medicina, Instituto de Investigaciones en Microbiología y Parasitología Médica, Consejo Nacional de Investigaciones Científicas y Técnicas.
    Background: Strongyloides stercoralis affects 30-100 million people worldwide. The first-line therapy is ivermectin. Cure is defined as the absence of larvae by parasitological methods 1 year after treatment. Read More

    A Case of Bacteremia and Meningitis Associated with Piperacillin-Tazobactam Nonsusceptible, Ceftriaxone Susceptible during Hyperinfection in an Immunocompromised Host.
    Case Rep Infect Dis 2017 22;2017:8634717. Epub 2017 Nov 22.
    Department of Internal Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, New Rochelle, NY 10801, USA.
    Strongyloidiasis is an emerging parasitic infection with intriguing epidemiology, presentation, and clinical management. We report a case of hyperinfection syndrome complicated by bacteremia and meningitis with one of the isolates showing a unique resistance pattern recently being recognized. This report describes the aspect of invasive bacterial infections in strongyloidiasis and highlights the unique susceptibility pattern of the isolate and the extreme caution required during the antibiotic therapy. Read More

    Chronic strongyloidiasis with recurrent asthma exacerbations and steroid-associated 'hives'.
    BMJ Case Rep 2018 Jan 17;2018. Epub 2018 Jan 17.
    Department of Medicine, New York University School of Medicine, New York City, New York, USA.
    A 74-year-old man experienced worsening asthma for several years. Oral steroids were required on multiple occasions for asthma treatment. During his steroid courses, he developed a hive-like rash, which would resolve after completion of each steroid course. Read More

    Strongyloides stercoralis and hookworm co-infection: spatial distribution and determinants in Preah Vihear Province, Cambodia.
    Parasit Vectors 2018 01 12;11(1):33. Epub 2018 Jan 12.
    Swiss Tropical and Public Health Institute, Basel, Switzerland.
    Background: Strongyloides stercoralis and hookworm are two soil-transmitted helminths (STH) that are highly prevalent in Cambodia. Strongyloides stercoralis causes long-lasting infections and significant morbidity but is largely neglected, while hookworm causes the highest public health burden among STH. The two parasites have the same infection route, i. Read More

    Surveillance of strongyloidiasis in Spanish in-patients (1998-2014).
    PLoS One 2017 28;12(12):e0189449. Epub 2017 Dec 28.
    Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS, Barcelona, Spain.
    Background: Strongyloides stercoralis is a parasite that causes strongyloidiasis, a neglected tropical disease. S. stercoralis is a soil-transmitted helminth that is widely distributed in tropical and subtropical regions of the world. Read More

    Importance of a Rapid and Accurate Diagnosis in and Human T-Lymphotropic Virus 1 Co-infection: A Case Report and Review of the Literature.
    Front Microbiol 2017 6;8:2346. Epub 2017 Dec 6.
    Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
    and Human T-Lymphotropic Virus 1 (HTLV-1) share some endemic regions such as Japan, Jamaica, and South America and are mostly diagnosed elsewhere in immigrants from endemic areas. This co-infection has not been documented in Argentina although both pathogens are endemic in the Northwest. We present a case of and HTLV-1 co-infection with an initial presentation due to gastrointestinal symptoms which presented neither eosinophilia nor the presence of larvae in stool samples in a non-endemic area for these infections. Read More

    Immune complex detection in saliva samples: an innovative proposal for the diagnosis of human strongyloidiasis.
    Parasitology 2017 Dec 14:1-5. Epub 2017 Dec 14.
    Departamento de Ciências Patológicas,Laboratório de Parasitologia,Universidade Estadual de Londrina,Londrina PR,Brazil.
    Human strongyloidiasis is caused by helminth Strongyloides stercoralis. It has a worldwide distribution, often neglected and cause of severe morbidity. The parasitological diagnosis is hindered by the low and irregular amount of larvae in feces. Read More

    Biliary With Cholecystitis and Extensive Portal Vein Thrombosis.
    Open Forum Infect Dis 2017 8;4(4):ofx217. Epub 2017 Oct 8.
    Department of Internal Medicine.
    We report the rare finding of rhabditiform larvae in biliary fluid, here associated with cholecystitis and near total portal vein thrombosis. The role of leading to atypical clinical presentations and difficulty diagnosing strongyloidiasis in such patients with appropriate geographic exposure is discussed. Read More

    Influence of parasite load on the diagnosis and occurrence of eosinophilia in alcoholic patients infected with Strongyloides stercoralis.
    J Helminthol 2017 Nov 28:1-5. Epub 2017 Nov 28.
    Departamento de Análises Clínicas e Toxicológicas,Faculdade de Farmácia,Universidade Federal da Bahia,Salvador,Bahia,Brazil.
    Alcoholic patients are more susceptible to Strongyloides stercoralis infection. The chronic use of alcohol raises the levels of endogenous corticosteroids, which regulates the development of larvae and stimulates the differentiation of rhabditiform into infective filariform larvae, thus inducing internal autoinfection. Therefore, early diagnosis is important to prevent severe strongyloidiasis. Read More

    Newly Arrived African Migrants to Spain: Epidemiology and Burden of Disease.
    Am J Trop Med Hyg 2018 Jan;98(1):319-325
    RICET (Red de Investigación Cooperativa en Enfermedades Tropicales).
    The aim of this study is to describe the epidemiological profile, clinical characteristics, and microbiological findings in African immigrants newly arrived to Spain attended at a specialized reference unit from October 2004 to February 2017. A common protocol for the screening of imported and cosmopolitan diseases was designed to evaluate patients with ≤ 12 months of stay in Spain. A total of 523 patients were included in the study, 488 (93. Read More

    Acute strongyloidiasis in a child recently returned from vacation in Cuba.
    CMAJ 2017 11;189(46):E1416-E1420
    Division of Infectious Diseases (Alabi, Bitnun), The Hospital for Sick Children; Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine (Boggild), Toronto General Hospital, University Health Network; Department of Medicine (Boggild) and Department of Paediatrics (Bitnun), University of Toronto; Public Health Ontario Laboratories (Boggild), Toronto, Ont.

    Case Report: Hyperinfection in a Patient with Chronic Lymphocytic Leukemia.
    Am J Trop Med Hyg 2017 Nov;97(5):1629-1631
    Department of Pathology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina.
    is an intestinal nematode that can cause disseminated infection in an immunocompromised host. It is most commonly acquired in developing countries. It was previously a common infection in many parts of the United States, particularly in the Appalachian region, but is rarely identified currently. Read More

    Case Report: A Case of Recurrent Colitis in a Patient with Multiple Myeloma.
    Am J Trop Med Hyg 2017 Nov;97(5):1619-1622
    Wright-Patterson Medical Center, Wright-Patterson Air Force Base, Ohio.
    chronic infection is frequently subclinical and thus under-recognized, although its increasing prevalence in nonendemic regions has implications for immunocompromised hosts. We present a 75-year-old male with stage II multiple myeloma who presented with relapse of infection after initial treatment, negative surveillance testing, and subsequent resumption of chemotherapy for his multiple myeloma. The optimal regimen for secondary prophylaxis against recurrent infections is unknown. Read More

    Status and Risk Factors of Strongyloides stercoralis Infection in Rural Communities of Xayaburi Province, Lao PDR.
    Korean J Parasitol 2017 Oct 31;55(5):569-573. Epub 2017 Oct 31.
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
    The present study was performed to reveal the current status and risk factors of Strongyloides stercoralis infections in the villages of Kenethao district, Xayaburi Province, Lao PDR. Fecal specimens were collected and examined for S. stercoralis using Koga-agar plate culture technique. Read More

    Electroacupuncture in rats infected with effects on gastrointestinal transit and parasitological measurements.
    Acupunct Med 2018 Feb 4;36(1):44-51. Epub 2017 Nov 4.
    Instituto de Ciências Biológicas e da Saúde, UFMT-Universidade Federal de Mato Grosso, Barra do Garças, Mato Grosso, Brazil.
    Objective: To investigate the effects of electroacupuncture (EA) at ST36 and CV12 on gastrointestinal transit and parasitological measurements during infection in rats.

    Design: Rats were infected with and allocated to one of three groups that were infected and remained untreated (SV group, n=8), infected and treated with EA at CV12 (SV+CV12 group, n=8) or infected and treated with EA at ST36 (SV+ST36 group, n=8). EA was performed every 3 days over a 21-day period, at 4 mA intensity and 15 Hz frequency for 20 min. Read More

    Strongyloides stercoralis is associated with significant morbidity in rural Cambodia, including stunting in children.
    PLoS Negl Trop Dis 2017 Oct 23;11(10):e0005685. Epub 2017 Oct 23.
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
    Background: Strongyloides stercoralis is a soil-transmitted nematode that can replicate within its host, leading to long-lasting and potentially fatal infections. It is ubiquitous and highly prevalent in Cambodia. The extent of morbidity associated with S. Read More

    Strongyloides stercoralis seroprevalence in Vietnam.
    Epidemiol Infect 2017 11 17;145(15):3214-3218. Epub 2017 Oct 17.
    Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme,Hanoi,Vietnam.
    Strongyloidiasis is a neglected tropical disease caused by the roundworm Strongyloides stercoralis affecting 30-100 million people worldwide. Many Southeast-Asian countries report a high prevalence of S. stercoralis infection, but there are little data from Vietnam. Read More

    Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study.
    PLoS Negl Trop Dis 2017 Oct 9;11(10):e0006003. Epub 2017 Oct 9.
    Instituto de Investigaciones en Enfermedades Tropicales, Universidad Nacional de Salta-Sede Regional Orán, San Ramón de la Nueva Orán, Salta, Argentina.
    Background: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate control, particularly against Strongyloides stercoralis. The impact of preventive chemotherapy (PC) against STH morbidity is still incompletely understood. The aim of this study was to assess the effectiveness of a community-based program with albendazole and ivermectin in a high transmission setting for S. Read More

    A case of adenocarcinoma developed in the small intestine with chronic strongyloidiasis.
    Clin J Gastroenterol 2017 Dec 7;10(6):519-523. Epub 2017 Oct 7.
    Department of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, Japan.
    We experienced a case of intestinal strongyloidiasis complicated by jejunal carcinoma. A Japanese male in his 50s, who has a 7-year medical history of duodenal ulcers, complained of loss of appetite, nausea, vomiting and diarrhea. Computed tomography and gastroduodenal endoscopic examination revealed a stenosis of the duodenum. Read More

    Helminths as an alternative therapy for intestinal diseases.
    World J Gastroenterol 2017 Sep;23(33):6009-6015
    LIM 07-Laboratory of Experimental Clinical Gastroenterology, Department of Gastroenterology and Hepatology, Clínicas Hospital of University of São Paulo-HCFMUSP and, School of Medicine at the University of São Paulo, São Paulo 04023-062, Brazil.
    Animal models and clinical studies have shown that helminth infections exert immunomodulatory activity, altering intestinal permeability and providing a potential beneficial action on autoimmune and inflammatory disorders in human beings, such as inflammatory bowel disease (IBD) and celiac disease. This is consistent with the theory that intestinal microbiota is responsible for shaping human immunological responses. With the arrival of the immunobiologic era and the use of antibodies, we propose a distinctive pathway for treating patients with IBD and celiac disease. Read More

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