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Biosensors (Basel) 2022 Jun 16;12(6). Epub 2022 Jun 16.

Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain.

Nucleic acid amplification diagnostics offer outstanding features of sensitivity and specificity. However, they still lack speed and robustness, require extensive infrastructure, and are neither affordable nor user-friendly. Thus, they have not been extensively applied in point-of-care diagnostics, particularly in low-resource settings. Read More

Emerg Infect Dis 2022 Jul;28(7):1531-1533

Widespread use of corticosteroids for COVID-19 treatment has led to Strongyloides reactivation and severe disease in patients from endemic areas. We describe a US patient with COVID-19 and Strongyloides hyperinfection syndrome and review other reported cases. Our findings highlight the need for Strongyloides screening and treatment in high-risk populations. Read More

IDCases 2022 6;29:e01530. Epub 2022 Jun 6.

University of Missouri, Department of Pathology and Anatomical Sciences, Columbia, MO, USA.

is a soil-transmitted helminth endemic to tropical and subtropical regions and can be acquired due to parasite penetration through the skin. It can remain dormant in the gastrointestinal system for decades after the primary infection. In immunocompromised patients, this parasite can cause autoinfection with progression to hyperinfection syndrome. Read More

Sci Rep 2022 Jun 15;12(1):9957. Epub 2022 Jun 15.

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.

Strongyloidiasis is a neglected tropical disease caused by the soil-transmitted nematode by Strongyloides stercoralis, that affects approximately 600 million people worldwide. In immunosuppressed individuals disseminated strongyloidiasis can rapidly lead to fatal outcomes. There is no gold standard for diagnosing strongyloidiasis, and infections are frequently misdiagnosed. Read More

Mol Biochem Parasitol 2022 Jun 11;250:111490. Epub 2022 Jun 11.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX USA.

Mechanisms governing morphogenesis and development of infectious third-stage larvae (L3i) of parasitic nematodes have been likened to those regulating dauer development in Caenorhabditis elegans. Dauer regulatory signal transduction comprises initial G protein-coupled receptor (GPCR) signaling in chemosensory neurons of the amphidial complex that regulates parallel insulin- and TGFβ-like signaling in the tissues. Insulin- and TGFβ-like signals converge to co-regulate steroid signaling through the nuclear receptor (NR) DAF-12. Read More

Mol Biochem Parasitol 2022 Jun 10;250:111491. Epub 2022 Jun 10.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

The oft-neglected human-parasitic threadworm, Strongyloides stercoralis, infects roughly eight percent of the global population, placing disproportionate medical and economic burden upon marginalized communities. While current chemotherapies treat strongyloidiasis, disease recrudescence and the looming threat of anthelminthic resistance necessitate novel strategies for nematode control. Throughout its life cycle, S. Read More

Ann Med Surg (Lond) 2022 Jun 4;78:103911. Epub 2022 Jun 4.

Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction: and importance: There are increasing case reports of mucormycosis in patient with coronavirus disease 2019 (Covid-19). Herein, we describe the case of mucormycosis after recovery from Covid-19.

Case Presentation: The patient was a 73 years old woman with a history of chronic kidney disease, diabetes mellitus, hypertension, and dyslipidemia that referred to the emergency department with clinical presentation of Covid-19. Read More

Parasit Vectors 2022 Jun 8;15(1):197. Epub 2022 Jun 8.

Instituto de Investigaciones de Enfermedades Tropicales (IIET), Sede Regional Orán Universidad Nacional de Salta, Salta, Argentina.

Background: The WHO has established a control strategy for Strongyloides stercoralis in school-aged children as well as targets and to maintain control programs for Ascaris lumbricoides, Trichuris trichiura and hookworms. For an efficient development of control programs, it is necessary to know the target countries around the world, as well as the areas within each country where efforts should be focused. Therefore, maps that provide information on the areas at risk for soil-transmitted helminth (STH) infections on a national and sub-national scale would allow for a better allocation of resources. Read More

PLoS One 2022 31;17(5):e0269080. Epub 2022 May 31.

Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Several studies have demonstrated that helminth infections provide a degree of protection against Type 2 diabetes mellitus (T2DM). However, the relationship between Strongyloides stercoralis infection and T2DM has scarcely been investigated and the protective effect of infection against development of diabetic complications is unclear. In this study, we aimed to investigate the relationship between S. Read More

Sensors (Basel) 2022 May 12;22(10). Epub 2022 May 12.

Laboratory of Nanobiotechnology, Institute of Biotechnology, Federal University of Uberlândia, Avenida Amazonas s/n Bl. 2E, sl. 248, Uberlândia 38402-022, Minas Gerais, Brazil.

Here, we describe 4-dimethylaminoantipyrine (4-DMAA)-mediated interfacing as a broad biochemical indicator to stabilize and promote the higher response of electrodes for immunological detection. We hypothesized that the improved biological interactions of 4-DMAA with electrodes and biological samples may be due to the interaction properties of the benzene and pyrazole chemical groups with graphite and proteins, respectively. In order to demonstrate that 4-DMAA could be used as a general indicator in electrochemical immunoassays, we used peptides as probes for the diagnosis of four neglected tropical infectious diseases , , , and on commercial graphite screen-printed electrodes. Read More

Med J Aust 2022 Jun 26;216(11):561-562. Epub 2022 May 26.

Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, VIC.

IDCases 2022 20;28:e01520. Epub 2022 May 20.

Thomas Jefferson University Hospital, Division of Infectious Diseases, United States.

Strongyloidiasis is a worldwide parasitic infection. Many who develop infection remain asymptomatic. Due to Stronygloides autoinfection cycle it can result in chronic infection over decades. Read More

Cureus 2022 Apr 13;14(4):e24097. Epub 2022 Apr 13.

Infectious Diseases, University of Florida College of Medicine, Jacksonville, USA.

Strongyloidiasis is endemic to socioeconomically disadvantaged tropics and subtropics, primarily as an asymptomatic carriage. It is seen in developed nations among the underprivileged. We describe a case of an Asian immigrant with eosinophilia, common bile duct stricture, cholangitis, and pancreatitis with  spp found on duodenal biopsy in the setting of steroid exposure. Read More

Parasit Vectors 2022 May 15;15(1):168. Epub 2022 May 15.

Institute of Parasitology, University of Veterinary Medicine Vienna, Vienna, Austria.

Background: Strongyloides stercoralis is endemic in tropical and subtropical regions, but reports of infections in central and northern Europe have been recently increasing. Infections occur mainly in humans and dogs. In dogs, both dog-adapted and zoonotic S. Read More

Vet Parasitol Reg Stud Reports 2022 Jun 30;31:100737. Epub 2022 Apr 30.

DILAVE Miguel C. Rubino, Laboratorio Regional Este, Avelino Miranda 2045, CP 33000 Treinta y Tres, Uruguay. Electronic address:

Here, we describe a spontaneous outbreak of strongyloidiasis (Strongyloides papillosus) in sheep in Uruguay. In a flock of 150 lambs, 60 animals became ill and 12 died within 3 weeks. Affected animals showed weakness, weight loss, enophthalmos and, in some cases, sudden death. Read More

Med J Aust 2022 Jun 12;216(10):532-538. Epub 2022 May 12.

Australian National University, Canberra, ACT.

•Neglected tropical diseases (NTDs) represent a threat to the health, wellbeing and economic prosperity of billions of people worldwide, often causing serious disease or death. •Commonly considered diseases of low and middle-income nations, the presence of NTDs in high income countries such as Australia is often overlooked. •Seven of the 20 recognised NTDs are endemic in Australia: scabies, soil-transmitted helminths and strongyloidiasis, echinococcosis, Buruli ulcer, leprosy, trachoma, and snakebite envenoming. Read More

Radiol Clin North Am 2022 May;60(3):461-479

Alliar Group, Rua Ernesto Nazaré, 389 - Alto de Pinheiros, São Paulo, São Paulo 05462-000, Brazil.

Although many of the thoracic infections endemic to Africa are also present around the world, this article focuses on entities that are emerging or disproportionately affect populations living in sub-Saharan Africa. Important emerging or reemerging viral and bacterial diseases that commonly affect the lung include dengue fever, plague, leptospirosis, and rickettsioses. Most parasitic infections endemic to Africa can also manifest within the thorax, including malaria, amebiasis, hydatid disease, schistosomiasis, paragonimiasis, ascariasis, strongyloidiasis and cysticercosis. Read More

Rev Med Suisse 2022 May;18(780):898-902

Service de médecine tropicale et humanitaire, Département de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.

Before starting immunosuppressive therapy, it is important to screen for latent tuberculosis and, in case of particular exposures (e.g. travel, origin,…), for parasitosis such as amoebiasis, echinococcosis, strongyloidiasis and American trypanosomiasis. Read More

PLoS Negl Trop Dis 2022 04 28;16(4):e0010299. Epub 2022 Apr 28.

Mundo Sano Foundation and Institute of Health Carlos III, Madrid, Spain.

Background: Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. Read More

Biomedica 2022 03 1;42(1):31-40. Epub 2022 Mar 1.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil.

Introduction: Individuals infected with the human T-lymphotropic virus type 1 (HTLV-1) may present severe and disseminated forms of Strongyloides stercoralis infection with low therapeutic response.

Objective: To investigate the S. stercoralis infection and the seroprevalence of IgG anti-S. Read More

Front Med (Lausanne) 2022 7;9:835252. Epub 2022 Apr 7.

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Background: Strongylodiasis may be asymptomatic or cause mild gastrointestinal symptoms, and may be a fatal disseminated disease or hyperinfection syndrome. Non-specific clinical manifestations, such as pneumonia and gastroenteritis, pose a diagnostic dilemma.

Case Presentation: We report a case of a 67-year-old Chinese male who presented with abdominal pain, fever, headache, vomiting, constipation, and slight cough with sputum for nearly 2 months. Read More

Parasit Vectors 2022 Apr 23;15(1):142. Epub 2022 Apr 23.

Department of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024, Negrar, Verona, Italy.

Background: Strongyloidiasis, a nematode infection which is mainly caused by Strongyloides stercoralis in humans, can lead to a fatal syndrome in immunocompromised individuals. Its diagnosis is challenging due to the absence of a diagnostic gold standard. The infection is highly prevalent in migrants from endemic countries in tropical and subtropical areas, and a rapid diagnostic test would be helpful for screening purposes. Read More

N Engl J Med 2022 Apr;386(16):1559

Hospital Universitario 12 de Octubre, Madrid, Spain

Parasite Immunol 2022 Jul 9;44(7):e12920. Epub 2022 May 9.

Laboratório de Investigação Médica (LIM-06), Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.

Strongyloidiasis is a chronic and asymptomatic infection in immunocompetent patients. Immunocompromised patients, such as organ transplant candidates, can develop severe forms of this disease, and the best way to prevent progression to these forms is early diagnosis. Serological techniques using specific IgG and immune complexes (IC) detection can help in the diagnosis of these patients. Read More

Acta Trop 2022 Jul 12;231:106465. Epub 2022 Apr 12.

Dipartimento di Medicina Veterinaria, Università di Bari, Str. prov. per Casamassima km 3, Valenzano 70010, Italy.

Strongyloides stercoralis is a soil-transmitted helminth with an unusual life cycle, causing canine and human strongyloidiasis, mainly endemic in tropical and subtropical areas. Following percutaneous or oral transmission of infective third-stage larvae in the vertebrate host, the parasite can cause autoinfection, leading to life-long infection. At present, the transmammary transmission was only assessed in experimentally infested dogs. Read More

BMJ Case Rep 2022 Apr 11;15(4). Epub 2022 Apr 11.

Department of Pulmonary & Critical Care Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.

A 49-year-old man was admitted with altered mental status, high-grade fevers, tachycardia and leucocytosis. Cerebrospinal fluid (CSF) was purulent with a markedly elevated nucleated cell count with neutrophilic predominance, elevated protein and low glucose. CSF gram stain was negative. Read More

Eur J Case Rep Intern Med 2022 3;9(3):003008. Epub 2022 Mar 3.

Norton Community Hospital, Ballad Health, Norton, VA, USA.

Introduction: Strongyloidiasis is a systemic disease caused by the nematode . is unique among parasites in that it can remain undetected for decades. Although patients may present with the typical symptoms of a skin rash, cough or diarrhoea, a rare manifestation of infection is pseudopolyposis in the colon. Read More

Lung 2022 04 9;200(2):141-148. Epub 2022 Apr 9.

Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Strongyloidiasis has been estimated to affect over 600 million people worldwide. It is caused by Strongyloides stercoralis, a roundworm endemic to the tropics and subtropics, especially areas where sanitation is suboptimal Autochthonous transmission has been documented in rural areas of the USA and Europe. Humans are infected when larvae penetrate the skin or are ingested. Read More

BMJ Case Rep 2022 04 4;15(4). Epub 2022 Apr 4.

Section of Nephrology, Yale University Department of Internal Medicine, New Haven, Connecticut, USA.

Travel Med Infect Dis 2022 Jul-Aug;48:102324. Epub 2022 Apr 1.

Department of Infectious - Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024, Via Don A Sempreboni 5, Negrar di Valpolicella, Verona, Italy.

Introduction: Screening HIV-positive migrants for neglected tropical diseases having potential for life-threatening reactivation, such as Chagas disease and strongyloidiasis is not widely implemented. We evaluated the prevalence of these infections among a large cohort of HIV-infected migrants from Latin America living in Italy.

Method: Cross-sectional study evaluating the prevalence of Trypanosoma cruzi and Strongyloides stercoralis infections in HIV-infected migrants from Latin America enrolled in the Italian Cohort of Antiretroviral-Naïve patients (ICONA) between 1997 and 2018, based on serology performed on sera stored in the ICONA Foundation biobank. Read More