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Biomedica 2021 05 31;41(Supl. 1):35-46. Epub 2021 May 31.

Área de Parasitología y Bioterios, Gestión de Investigación, Desarrollo e Innovación, Instituto Nacional de Investigación en Salud Pública Leopoldo Izquieta Pérez, Quito, Ecuador.

Introduction: Strongyloides venezuelensis is a nematode whose natural host is rats. It is used as a model for the investigation of human strongyloidiasis caused by S. stercoralis. Read More

BMJ Case Rep 2021 Jun 1;14(6). Epub 2021 Jun 1.

Department of Histopathology, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain.

A 45-year-old man presents with 48-hour status of high temperature, cough and dyspnoea. In the context of pandemic, the patient is initially diagnosed with COVID-19 syndrome. Later, the laboratory and ultrasound study supported acute appendicitis diagnosis. Read More

J Clin Pharm Ther 2021 Jun 2. Epub 2021 Jun 2.

Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.

What Is Known And Objective: The rhabditid nematode Strongyloides stercoralis is the major causative agent of disseminated strongyloidiasis (DS). In rare cases, DS has caused enterococcal meningitis. If DS-associated vancomycin-resistant Enterococcus faecium (VRE) meningitis is suspected, combination antibiotic therapy should be considered. Read More

Curr Opin Infect Dis 2021 Jun 1. Epub 2021 Jun 1.

Unidad Trasplante Médula Ósea, Hospital Británico Latin American Bone Marrow Transplantation Group (LABMT) Programa Nacional Trasplante Hepático Cátedra de Infectología, Facultad de Medicina, UDELAR, Montevideo, Uruguay.

Purpose Of Review: The aim of the article is to review recent recommendations on the management of Strongyloidiasis and Chagas disease (ChD) in the context of stem-cell or solid-organ transplantation.

Recent Findings: An update on laboratory screening, detection of acute disease or reactivation and recommended preventive or therapeutic options in the transplant recipients and donors is presented. Recent epidemiological data showing new estimates on the worldwide burden of both diseases and changes in the classical distribution around the globe should increase awareness and will impact the evaluation and management of transplant recipients and donors in endemic and nonendemic regions. Read More

Diagnostics (Basel) 2021 May 28;11(6). Epub 2021 May 28.

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang 11800, Malaysia.

Strongyloidiasis, caused mainly by the nematode , is prevalent worldwide and potentially fatal in immunosuppressed patients. We report on a new IgE biomarker to diagnose infection. Sera from two groups infected with served as positive samples: Group 1A, in which infection was confirmed by stool-microscopy and/or stool-polymerase chain reaction (PCR) and was seropositive by an IgG-enzyme linked immunosorbent assay (ELISA) and an IgG4 rapid test, and Group 1B in which infection was confirmed by stool-PCR but was seronegative. Read More

Acta Trop 2021 May 28;221:105986. Epub 2021 May 28.

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), 11800 Penang, Malaysia. Electronic address:

Serodiagnosis is an essential component of the laboratory diagnosis of Strongyloides infection and is usually performed using an indirect IgG antibody test. A direct antigen detection method can complement the IgG assay, particularly for detecting early infection and post-treatment follow-up. In the present study, a recombinant scFv monoclonal antibody against NIE recombinant protein (rMAb23) that we had previously produced was used to develop a Strongyloides antigen detection ELISA (SsAg-ELISA). Read More

J Travel Med 2021 May 28. Epub 2021 May 28.

Internal Medicine Department, Hospital de Viladecans, Institut Català de la Salut, Viladecans (Barcelona), Spain.

Ann Med Surg (Lond) 2021 Jun 13;66:102367. Epub 2021 May 13.

Pathology Department, Farhat Hached University Hospital, 4000, Sousse, Tunisia.

Introduction: , an intestinal nematode, is commonly dispersed throughout the tropical and subtropical regions. infection typically contributes to an asymptomatic chronic disease which can remain hidden for decades. However, in immunocompromised patients, the hyperinfection can take place, causing high mortality rates. Read More

Infect Dis Poverty 2021 May 25;10(1):76. Epub 2021 May 25.

Department of Health Sciences, University of Florence, Florence, Italy.

Background: Implementation of control programmes for Strongyloides stercoralis infection is among the targets of the World Health Organization Roadmap to 2030. Aim of this work was to evaluate the possible impact in terms of economic resources and health status of two different strategies of preventive chemotherapy (PC) compared to the current situation (strategy A, no PC): administration of ivermectin to school-age children (SAC) and adults (strategy B) versus ivermectin to SAC only (strategy C).

Methods: The study was conducted at the IRCCS Sacro Cuore Don Calabria hospital, Negrar di Valpolicella, Verona, Italy, at the University of Florence, Italy, and at the WHO, Geneva, Switzerland, from May 2020 to April 2021. Read More

Infection 2021 May 10. Epub 2021 May 10.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Infect Dis Poverty 2021 May 7;10(1):65. Epub 2021 May 7.

School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.

Background: Strongyloidiasis is the most neglected of the neglected tropical diseases (NTDs). The aim of this commentary is to describe the possible reasons why strongyloidiasis is so overlooked in Ethiopia, and shed light on better ways of control and elimination of the disease.

Main Body: This commentary highlights three points why strongyloidiasis is the most neglected of the NTDs in Ethiopia. Read More

Germs 2021 Mar 15;11(1):116-119. Epub 2021 Mar 15.

MD, PhD, Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, 119435 Moscow, Russia.

Introduction: At present, strongyloidiasis is considered by the World Health Organizaiton (WHO) as one of the most neglected diseases.

Case Report: A husband and a wife, both born in the Moscow region and never having traveled, initially presented with fever and unexplained peripheral eosinophilia. Parasitological examination revealed in feces samples. Read More

United European Gastroenterol J 2021 May 22;9(4):517-518. Epub 2021 Apr 22.

Department of Gastroenterology, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisbon, Portugal.

J Clin Microbiol 2021 Apr 20;59(5). Epub 2021 Apr 20.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

Am J Trop Med Hyg 2021 Apr 19. Epub 2021 Apr 19.

4Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.

Strongyloides stercoralis is a soil-transmitted nematode that can cause life-threatening conditions in immunocompromised persons. In the United States, strongyloidiasis should be considered mainly in immigrants, refugees, or travelers. The confirmatory laboratory diagnosis is usually performed by detecting larvae from the stool, duodenal material, and sputum. Read More

PLoS Negl Trop Dis 2021 Apr 15;15(4):e0009314. Epub 2021 Apr 15.

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.

Background: Strongyloides stercoralis is a soil-transmitted helminth (STH) that affects approximately 600 million people worldwide. Interventions targeting S. stercoralis have not been implemented yet. Read More

Transpl Infect Dis 2021 Apr 12:e13614. Epub 2021 Apr 12.

Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.

Disseminated strongyloidiasis and hyperinfection syndrome can cause significant morbidity and mortality after transplantation. Screening and treatment prior to transplantation can reduce or prevent this disease. Targeted screening of transplant candidates based on assessed risk, fails to identify all who would benefit. Read More

Sensors (Basel) 2021 Mar 10;21(6). Epub 2021 Mar 10.

Laboratory of Nanobiotechnology, Institute of Biotechnology, Federal University of Uberlandia, Av. Amazonas s/n Bl. 2E, sl. 248, Uberlândia, MG 38402-022, Brazil.

(1) Background: The validation of biological antigens is the study's utmost goal in biomedical applications. We evaluated three different probes with single and multiple epitopes through electrochemical detection of specific IgG in serum for human strongyloidiasis diagnosis. (2) Methods: Screen-printed gold electrodes were used and probes consisting of two single-epitope synthetic peptides (D3 and C10) with different sequences, and a multi-epitope antigen [detergent phase (DP)-hydrophobic membrane proteins]. Read More

Lancet Infect Dis 2021 Mar 30. Epub 2021 Mar 30.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

Background: Strongyloidiasis represents a major public health issue, particularly in resource-limited countries. Preliminary studies suggest that moxidectin might serve as an alternative to the only available treatment option, ivermectin. We aimed to evaluate the efficacy and safety of ascending doses of moxidectin in Strongyloides stercoralis-infected patients. Read More

J Pharm Pharmacol 2021 Mar;73(3):377-387

Chemical, Biological and Agricultural Pluridisciplinary Research Center, University of Campinas, Campinas, SP, Brazil.

Objectives: To evaluate the antibacterial, antifungal and anthelmintic activities of the ethanolic extract (EEMz), fractions (LPFMz and HPFMz) and compounds isolated from the leaves of Manilkara zapota L. P. Royen. Read More

Support Care Cancer 2021 Mar 24. Epub 2021 Mar 24.

Department of Infectious Diseases, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.

Purpose: Contention surrounds how best to screen patients for latent and undiagnosed infection prior to cancer treatment. Early treatment and prophylaxis against reactivation may improve infection-associated morbidity. This study sought to examine rates of screening and prevalence of latent infection in overseas-born patients receiving cancer therapies. Read More

Clin Med (Lond) 2021 03;21(2):e239-e240

University of the Ryukyus, Nishihara, Japan.

A 74-year-old woman carrying the human T-lymphotropic virus type-1 (HTLV-1) presented with abdominal pain and vomiting. Computed tomography and microscopic analysis of the gastroduodenal drainage fluid made a diagnosis of paralytic ileus due to hyperinfection with underlying HTLV-1 infection. Strongyloidiasis should be included in the differential diagnosis for paralytic ileus in patients who have lived in or migrated from the endemic regions. Read More

Acta Trop 2021 Jun 20;218:105896. Epub 2021 Mar 20.

Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute (CARI), Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Recent work has found urine analysis to be as sensitive as serology for diagnosis of strongyloidiasis. Here, we examined the daily variation of Strongyloides-specific IgG in urine by qualitative and quantitative ELISA and its effects on diagnostic accuracy and reliability. In the first part of the study, matched urine and fecal samples were collected from project participants in northeast Thailand for three consecutive days. Read More

Acta Parasitol 2021 Mar 19. Epub 2021 Mar 19.

Department of Otolaryngology Head and Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, 030001, China.

Introduction: Human strongyloidiasis is a generally neglected parasitic disease of major global distribution, spreading commonly in tropical and subtropical areas. As for China, strongyloidiasis occur mainly in South of China and no relevant information about the parasite infection in North China was available.

Case Presentation: An 84-year-old man from Shanxi province, North China, was admitted to Department of Nephrology with complaints of a 7-month history of intermittent edema of both lower extremity with foam urine and 3-day history of fever, chill and diarrhea. Read More

PLoS Negl Trop Dis 2021 Mar 17;15(3):e0009144. Epub 2021 Mar 17.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, United Kingdom.

Background: Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg. Read More

Microorganisms 2021 Feb 15;9(2). Epub 2021 Feb 15.

Department of Infectious Tropical Diseases and Microbiology (DITM), IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar, Italy.

infection is a life-threatening neglected tropical disease. Diagnostic issues have caused an underestimation of its global burden. The choice of appropriate diagnostic tests for the screening of populations at risk of the infection, such as migrants from endemic countries, is of paramount importance. Read More

Int J Mol Sci 2021 Feb 21;22(4). Epub 2021 Feb 21.

Department of Diagnostic and Laboratory Medicine, Unit of Parasitology and Multimodal Laboratory Medicine Research Area, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Strongyloidiasis is a neglected tropical disease caused by the intestinal nematode and characterized by gastrointestinal and pulmonary involvement. We report a pediatric case of strongyloidiasis to underline the response of the host microbiota to the perturbation induced by the nematode. We performed a 16S rRNA-metagenomic analysis of the gut microbiota of a 7-year-old female during and after infection, investigating three time-point of stool samples' ecology: T- during parasite infection, T- a month after parasite infection, and T- two months after parasite infection. Read More

Rev Med Inst Mex Seguro Soc 2021 02 2;59(1):87-94. Epub 2021 Feb 2.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Manuel Ávila Camacho, Hospital de Especialidades, Servicio de Anatomía Patológica, Puebla, Puebla, México.

Background: Strongyloides stercolaris is one of the most important intestinal nematodes due to its worldwide distribution. It’s estimated that it affects 50 to 100 million people in 70 countries of the world. In a large percentage of cases it is asymptomatic, however, patients with immunosuppression may present more serious symptoms. Read More

Helminthologia 2021 Mar 10;58(1):17-27. Epub 2021 Feb 10.

Biology Department, Science College, Bahir Dar University, Bahir Dar, Ethiopia.

is a helminthic intestinal parasite that causes the disease strongyloidiasis. Its prevalence is high in tropics and sub-tropics due to poor sanitation and hygiene. However, its true prevalence is not well known in Ethiopia as most health institutions use low sensitive diagnostic methods. Read More

Braz J Infect Dis 2021 Mar-Apr;25(2):101545. Epub 2021 Feb 23.

Universidade Federal de Uberlândia, Instituto de Genética e Bioquímica, Laboratório de Nanobiotecnologia, Uberlândia, MG, Brazil; Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA.

Strongyloidiasis is a helminthiasis of neglected condition that has no gold standard parasitological diagnosis due to the intermittent release of larvae in feces. This study aimed to use an scFv (single chain variable fragment) obtained by Phage Display, previously validated to detect immune complexes in serum samples from individuals infected with Strongyloides stercoralis by enzyme-linked immunosorbent assay (ELISA). Now the ability of scFv to detect the immune complexes was verified by immunofluorescence, flow cytometry using magnetic beads and surface plasmon resonance (SPR). Read More