2,969 results match your criteria Strongyloides Stercoralis


Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey: Haiti 2014-2015.

Front Public Health 2022 9;10:897013. Epub 2022 Jun 9.

Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States.

Background: Integrated surveillance for multiple diseases can be an efficient use of resources and advantageous for national public health programs. Detection of IgG antibodies typically indicates previous exposure to a pathogen but can potentially also serve to assess active infection status. Serological multiplex bead assays have recently been developed to simultaneously evaluate exposure to multiple antigenic targets. Read More

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Diagnostic challenge of Strongyloides stercoralis hyperinfection syndrome: a case report.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):79-81

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2. Read More

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Strongyloides Hyperinfection Syndrome among COVID-19 Patients Treated with Corticosteroids.

Emerg Infect Dis 2022 Jul;28(7):1531-1533

Widespread use of corticosteroids for COVID-19 treatment has led to Strongyloides reactivation and severe disease in patients from endemic areas. We describe a US patient with COVID-19 and Strongyloides hyperinfection syndrome and review other reported cases. Our findings highlight the need for Strongyloides screening and treatment in high-risk populations. Read More

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Evaluation of antibody serology to determine current helminth and Plasmodium falciparum infections in a co-endemic area in Southern Mozambique.

PLoS Negl Trop Dis 2022 06 21;16(6):e0010138. Epub 2022 Jun 21.

ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.

Background: Soil-transmitted helminths (STH), Schistosoma spp. and Plasmodium falciparum are parasites of major public health importance and co-endemic in many sub-Saharan African countries. Management of these infections requires detection and treatment of infected people and evaluation of large-scale measures implemented. Read More

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Interventions to improve water, sanitation, and hygiene for preventing soil-transmitted helminth infection.

Cochrane Database Syst Rev 2022 06 21;6:CD012199. Epub 2022 Jun 21.

Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Background: It is estimated that 1.5 billion people are infected with soil-transmitted helminths (STHs) worldwide. Re-infection occurs rapidly following deworming, and interruption of transmission is unlikely without complementary control efforts such as improvements in water, sanitation, and hygiene (WASH) access and behaviours. Read More

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Atypical pulmonary presentation of hyperinfection in a patient with philadelphia chromosome-positive acute lymphoblastic leukemia: Case report.

IDCases 2022 6;29:e01530. Epub 2022 Jun 6.

University of Missouri, Department of Pathology and Anatomical Sciences, Columbia, MO, USA.

is a soil-transmitted helminth endemic to tropical and subtropical regions and can be acquired due to parasite penetration through the skin. It can remain dormant in the gastrointestinal system for decades after the primary infection. In immunocompromised patients, this parasite can cause autoinfection with progression to hyperinfection syndrome. Read More

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Identification of miRNAs of Strongyloides stercoralis L1 and iL3 larvae isolated from human stool.

Sci Rep 2022 Jun 15;12(1):9957. Epub 2022 Jun 15.

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.

Strongyloidiasis is a neglected tropical disease caused by the soil-transmitted nematode by Strongyloides stercoralis, that affects approximately 600 million people worldwide. In immunosuppressed individuals disseminated strongyloidiasis can rapidly lead to fatal outcomes. There is no gold standard for diagnosing strongyloidiasis, and infections are frequently misdiagnosed. Read More

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The 'nuclear option' revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections.

Mol Biochem Parasitol 2022 Jun 11;250:111490. Epub 2022 Jun 11.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX USA.

Mechanisms governing morphogenesis and development of infectious third-stage larvae (L3i) of parasitic nematodes have been likened to those regulating dauer development in Caenorhabditis elegans. Dauer regulatory signal transduction comprises initial G protein-coupled receptor (GPCR) signaling in chemosensory neurons of the amphidial complex that regulates parallel insulin- and TGFβ-like signaling in the tissues. Insulin- and TGFβ-like signals converge to co-regulate steroid signaling through the nuclear receptor (NR) DAF-12. Read More

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Using newly optimized genetic tools to probe Strongyloides sensory behaviors.

Mol Biochem Parasitol 2022 Jun 10;250:111491. Epub 2022 Jun 10.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

The oft-neglected human-parasitic threadworm, Strongyloides stercoralis, infects roughly eight percent of the global population, placing disproportionate medical and economic burden upon marginalized communities. While current chemotherapies treat strongyloidiasis, disease recrudescence and the looming threat of anthelminthic resistance necessitate novel strategies for nematode control. Throughout its life cycle, S. Read More

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Mucormycosis, one month after recovery from COVID-19: A case report.

Ann Med Surg (Lond) 2022 Jun 4;78:103911. Epub 2022 Jun 4.

Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction: and importance: There are increasing case reports of mucormycosis in patient with coronavirus disease 2019 (Covid-19). Herein, we describe the case of mucormycosis after recovery from Covid-19.

Case Presentation: The patient was a 73 years old woman with a history of chronic kidney disease, diabetes mellitus, hypertension, and dyslipidemia that referred to the emergency department with clinical presentation of Covid-19. Read More

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Strongyloides stercoralis: Intriguing cough in an acute lymphoblastic leukemia patient.

Hematol Transfus Cell Ther 2022 Jun 2. Epub 2022 Jun 2.

Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA. Electronic address:

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Multi-Epitope Protein as a Tool of Serological Diagnostic Development for HTLV-1 and HTLV-2 Infections.

Front Public Health 2022 23;10:884701. Epub 2022 May 23.

Laboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

A multi-epitope protein expressed in a prokaryotic system, including epitopes of Env, Gag, and Tax proteins of both HTLV-1 and HTLV-2 was characterized for HTLV-1/2 serological screening. This tool can contribute to support the implementation of public policies to reduce HTLV-1/2 transmission in Brazil, the country with the highest absolute numbers of HTLV-1/2 infected individuals. The chimeric protein was tested in EIA using serum/plasma of HTLV-infected individuals and non-infected ones from four Brazilian states, including the North and Northeast regions (that present high prevalence of HTLV-1/2) and Southeast region (that presents intermediate prevalence rates) depicting different epidemiological context of HTLV-1/2 infection in our country. Read More

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Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling.

Parasit Vectors 2022 Jun 8;15(1):197. Epub 2022 Jun 8.

Instituto de Investigaciones de Enfermedades Tropicales (IIET), Sede Regional Orán Universidad Nacional de Salta, Salta, Argentina.

Background: The WHO has established a control strategy for Strongyloides stercoralis in school-aged children as well as targets and to maintain control programs for Ascaris lumbricoides, Trichuris trichiura and hookworms. For an efficient development of control programs, it is necessary to know the target countries around the world, as well as the areas within each country where efforts should be focused. Therefore, maps that provide information on the areas at risk for soil-transmitted helminth (STH) infections on a national and sub-national scale would allow for a better allocation of resources. Read More

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Association of Strongyloides stercoralis infection and type 2 diabetes mellitus in northeastern Thailand: Impact on diabetic complication-related renal biochemical parameters.

PLoS One 2022 31;17(5):e0269080. Epub 2022 May 31.

Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Several studies have demonstrated that helminth infections provide a degree of protection against Type 2 diabetes mellitus (T2DM). However, the relationship between Strongyloides stercoralis infection and T2DM has scarcely been investigated and the protective effect of infection against development of diabetic complications is unclear. In this study, we aimed to investigate the relationship between S. Read More

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Designing a Multi-Epitope Antigen for Serodiagnosis of Based on L3Nie.01 and IgG Immunoreactive Epitopes.

Avicenna J Med Biotechnol 2022 Apr-Jun;14(2):114-124

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Serological diagnosis of () is fre-quently challenging because of cross-reactivity with other parasitic nematodes. Therefore, it is necessary to introduce novel serological tests with high performance to properly diagnose this neglected parasitic infection. The purpose of the current study was to design a multi-epitope construct for the diagnosis of . Read More

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October 2021

Soil-Transmitted Helminths and Anaemia: A Neglected Association Outside the Tropics.

Microorganisms 2022 May 13;10(5). Epub 2022 May 13.

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, Italy.

Anaemia is an important cause of morbidity and mortality globally. Among infectious agents responsible for anaemia, helminthic infections are often neglected, particularly in non-endemic countries. However, they should not be neglected in this setting, as international travel and migration are on the rise. Read More

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Strongyloides hyperinfection: a preventable complication of immunosuppression.

Med J Aust 2022 Jun 26;216(11):561-562. Epub 2022 May 26.

Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, VIC.

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Thermosensation: How a human-infective nematode finds its host.

Curr Biol 2022 May;32(10):R464-R466

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

The parasitic nematode Strongyloides stercoralis locates human hosts via thermal cues through unknown neural mechanisms. A new study finds that the heat-sensing neuron AFD mediates attraction to human body heat. Interestingly, this neuron also mediates thermotaxis in the nematode C. Read More

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Strongyloides stercoralis infection in dogs in Austria: two case reports.

Parasit Vectors 2022 May 15;15(1):168. Epub 2022 May 15.

Institute of Parasitology, University of Veterinary Medicine Vienna, Vienna, Austria.

Background: Strongyloides stercoralis is endemic in tropical and subtropical regions, but reports of infections in central and northern Europe have been recently increasing. Infections occur mainly in humans and dogs. In dogs, both dog-adapted and zoonotic S. Read More

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[Parasite screening for immunosuppressed traveler].

Rev Med Suisse 2022 May;18(780):898-902

Service de médecine tropicale et humanitaire, Département de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.

Before starting immunosuppressive therapy, it is important to screen for latent tuberculosis and, in case of particular exposures (e.g. travel, origin,…), for parasitosis such as amoebiasis, echinococcosis, strongyloidiasis and American trypanosomiasis. Read More

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Cross-Sectional Assessment of the Association of Eosinophilia with Intestinal Parasitic Infection in U.S.-Bound Refugees in Thailand: Prevalent, Age Dependent, but of Limited Clinical Utility.

Am J Trop Med Hyg 2022 Mar 7. Epub 2022 Mar 7.

Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia.

The most common causes of eosinophilia globally are helminth parasites. Refugees from high endemic areas are at increased risk of infection compared with the general U.S. Read More

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The neural basis of heat seeking in a human-infective parasitic worm.

Curr Biol 2022 May 27;32(10):2206-2221.e6. Epub 2022 Apr 27.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

Soil-transmitted parasitic nematodes infect over one billion people and cause devastating morbidity worldwide. Many of these parasites have infective larvae that locate hosts using thermal cues. Here, we identify the thermosensory neurons of the human threadworm Strongyloides stercoralis and show that they display unique functional adaptations that enable the precise encoding of temperatures up to human body temperature. Read More

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Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia.

PLoS Negl Trop Dis 2022 04 28;16(4):e0010299. Epub 2022 Apr 28.

Mundo Sano Foundation and Institute of Health Carlos III, Madrid, Spain.

Background: Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. Read More

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Evaluation of Strongyloides stercoralis infection in patients with HTLV-1.

Biomedica 2022 03 1;42(1):31-40. Epub 2022 Mar 1.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil.

Introduction: Individuals infected with the human T-lymphotropic virus type 1 (HTLV-1) may present severe and disseminated forms of Strongyloides stercoralis infection with low therapeutic response.

Objective: To investigate the S. stercoralis infection and the seroprevalence of IgG anti-S. Read More

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Strongyloidiasis in a Patient Diagnosed by Metagenomic Next-Generation Sequencing: A Case Report.

Front Med (Lausanne) 2022 7;9:835252. Epub 2022 Apr 7.

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Background: Strongylodiasis may be asymptomatic or cause mild gastrointestinal symptoms, and may be a fatal disseminated disease or hyperinfection syndrome. Non-specific clinical manifestations, such as pneumonia and gastroenteritis, pose a diagnostic dilemma.

Case Presentation: We report a case of a 67-year-old Chinese male who presented with abdominal pain, fever, headache, vomiting, constipation, and slight cough with sputum for nearly 2 months. Read More

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The accuracy of a recombinant antigen immunochromatographic test for the detection of Strongyloides stercoralis infection in migrants from sub-Saharan Africa.

Parasit Vectors 2022 Apr 23;15(1):142. Epub 2022 Apr 23.

Department of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024, Negrar, Verona, Italy.

Background: Strongyloidiasis, a nematode infection which is mainly caused by Strongyloides stercoralis in humans, can lead to a fatal syndrome in immunocompromised individuals. Its diagnosis is challenging due to the absence of a diagnostic gold standard. The infection is highly prevalent in migrants from endemic countries in tropical and subtropical areas, and a rapid diagnostic test would be helpful for screening purposes. Read More

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Environmental-temperature and internal-state dependent thermotaxis plasticity of nematodes.

Authors:
Asuka Takeishi

Curr Opin Neurobiol 2022 Jun 18;74:102541. Epub 2022 Apr 18.

RIKEN Center for Brain Science, RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research, Japan. Electronic address:

Thermotaxis behavior of Caenorhabditis elegans is robust and highly plastic. A pair of sensory neurons, AFD, memorize environmental/cultivation temperature and communicate with a downstream neural circuit to adjust the temperature preference of the animal. This results in a behavioral bias where worms will move toward their cultivation temperature on a thermal gradient. Read More

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Cross-Sectional Study on Assessment of Frequency of Intestinal Helminth Infections and Its Related Risk Factors among School Children from Adola Town, Ethiopia.

Biomed Res Int 2022 11;2022:5908938. Epub 2022 Apr 11.

Parul Institute of Applied Sciences, Parul University, Vadodara, 391760 Gujarat, India.

The three main intestinal helminth infections (IHIs), ascariasis, trichuriasis, and hookworm, are common clinical disorders worldwide. These IHIs are more prevalent in tropics and subtropical countries especially in developing countries like sub-Saharan Africa responsible for morbidity, mortality, and physical as well as intellectual growth retardation in children. In Ethiopia, the burden of IHIs appears in all ages mainly due to factors like lack of education, low socio-economic status, and inadequate supply of drugs and proper awareness. Read More

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Larva Currens in Strongyloides Hyperinfection Syndrome.

N Engl J Med 2022 Apr;386(16):1559

Hospital Universitario 12 de Octubre, Madrid, Spain

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Immune complexes as a tool for strongyloidiasis immunodiagnosis in kidney and liver transplant candidate.

Parasite Immunol 2022 Jul 9;44(7):e12920. Epub 2022 May 9.

Laboratório de Investigação Médica (LIM-06), Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.

Strongyloidiasis is a chronic and asymptomatic infection in immunocompetent patients. Immunocompromised patients, such as organ transplant candidates, can develop severe forms of this disease, and the best way to prevent progression to these forms is early diagnosis. Serological techniques using specific IgG and immune complexes (IC) detection can help in the diagnosis of these patients. Read More

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