2,613 results match your criteria Stroke Motor Impairment


Action Observation for Neurorehabilitation in Apraxia.

Front Neurol 2019 3;10:309. Epub 2019 Apr 3.

IRCCS Fondazione Santa Lucia, Rome, Italy.

Neurorehabilitation and brain stimulation studies of post-stroke patients suggest that action-observation effects can lead to rapid improvements in the recovery of motor functions and long-term motor cortical reorganization. Apraxia is a clinically important disorder characterized by marked impairment in representing and performing skillful movements [gestures], which limits many daily activities and impedes independent functioning. Recent clinical research has revealed errors of visuo-motor integration in patients with apraxia. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00309
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http://dx.doi.org/10.3389/fneur.2019.00309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456663PMC
April 2019
2 Reads

Predicting Motor Outcome in Acute Intracerebral Hemorrhage.

AJNR Am J Neuroradiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurology (M.T., J.S., Y.S.), Girona Biomedical Research Institute, Dr Josep Trueta University Hospital, Girona, Spain.

Background And Purpose: Predicting motor outcome following intracerebral hemorrhage is challenging. We tested whether the combination of clinical scores and DTI-based assessment of corticospinal tract damage within the first 12 hours of symptom onset after intracerebral hemorrhage predicts motor outcome at 3 months.

Materials And Methods: We prospectively studied patients with motor deficits secondary to primary intracerebral hemorrhage within the first 12 hours of symptom onset. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A6038
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http://dx.doi.org/10.3174/ajnr.A6038DOI Listing
April 2019
1 Read

Limb linkage rehabilitation training-related changes in cortical activation and effective connectivity after stroke: A functional near-infrared spectroscopy study.

Sci Rep 2019 Apr 17;9(1):6226. Epub 2019 Apr 17.

Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing, 100176, China.

Stroke remains the leading cause of long-term disability worldwide. Rehabilitation training is essential for motor function recovery following stroke. Specifically, limb linkage rehabilitation training can stimulate motor function in the upper and lower limbs simultaneously. Read More

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http://dx.doi.org/10.1038/s41598-019-42674-0DOI Listing

Cardiovascular disease risk factors, tract-based structural connectomics, and cognition in older adults.

Neuroimage 2019 Apr 10;196:152-160. Epub 2019 Apr 10.

Department of Psychology, University of Illinois at Chicago, Chicago, IL, 60607, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, 60612, USA. Electronic address:

Cardiovascular disease risk factors (CVD-RFs) are associated with decreased gray and white matter integrity and cognitive impairment in older adults. Less is known regarding the interplay between CVD-RFs, brain structural connectome integrity, and cognition. We examined whether CVD-RFs were associated with measures of tract-based structural connectivity in 94 non-demented/non-depressed older adults and if alterations in connectivity mediated associations between CVD-RFs and cognition. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.024DOI Listing
April 2019
2 Reads

Feasibility and clinical experience of implementing a myoelectric upper limb orthosis in the rehabilitation of chronic stroke patients: A clinical case series report.

PLoS One 2019 12;14(4):e0215311. Epub 2019 Apr 12.

Brain Plasticity and NeuroRecovery Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America.

Individuals with stroke are often left with persistent upper limb dysfunction, even after treatment with traditional rehabilitation methods. The purpose of this retrospective study is to demonstrate feasibility of the implementation of an upper limb myoelectric orthosis for the treatment of persistent moderate upper limb impairment following stroke (>6 months).

Methods: Nine patients (>6 months post stroke) participated in treatment at an outpatient Occupational Therapy department utilizing the MyoPro myoelectric orthotic device. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215311PLOS
April 2019
1 Read

Dynamic Lycra® orthoses as an adjunct to arm rehabilitation after stroke: a single-blind, two-arm parallel group, randomized controlled feasibility trial.

Clin Rehabil 2019 Apr 12:269215519840403. Epub 2019 Apr 12.

4 Dundee Epidemiology and Biostatistics Unit (DEBU), Population Health Sciences (PHS), School of Medicine, University of Dundee, Dundee, UK.

Objective: The aim of this study was to explore the feasibility of conducting a randomized controlled trial of dynamic Lycra orthoses as an adjunct to arm rehabilitation after stroke and to explore the magnitude and direction of change on arm outcomes.

Design: This is a single-blind, two-arm parallel group, feasibility randomized controlled trial.

Setting: In-patient rehabilitation. Read More

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http://dx.doi.org/10.1177/0269215519840403DOI Listing

Comparison Between Movement-Based and Task-Based Mirror Therapies on Improving Upper Limb Functions in Patients With Stroke: A Pilot Randomized Controlled Trial.

Front Neurol 2019 26;10:288. Epub 2019 Mar 26.

Department of Rehabilitation Sciences, Tongji University School of Medicine, Shanghai, China.

The aim of this trial was to compare the effect of movement-based mirror therapy (MMT) and task-based mirror therapy (TMT) on improving upper limb functions in patients with stroke. A total of 34 patients with sub-acute stroke with mildly to moderately impaired upper limb motor functions. The participants were randomly allocated to one of three groups: MMT, TMT, and conventional treatment (CT). Read More

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http://dx.doi.org/10.3389/fneur.2019.00288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443927PMC
March 2019
1 Read

Caregiver-mediated exercises with e-health support for early supported discharge after stroke (CARE4STROKE): A randomized controlled trial.

PLoS One 2019 8;14(4):e0214241. Epub 2019 Apr 8.

Amsterdam Rehabilitation Research Centre, Reade, Amsterdam, The Netherlands.

Background And Purpose: We designed an 8-week caregiver-mediated exercise program with e-health support after stroke (CARE4STROKE) in addition to usual care with the aim to improve functional outcome and to facilitate early supported discharge by increasing the intensity of task specific training.

Methods: An observer-blinded randomized controlled trial in which 66 stroke patient-caregiver couples were included during inpatient rehabilitation. Patients allocated to the CARE4STROKE program trained an additional amount of 150 minutes a week with a caregiver and were compared to a control group that received usual care alone. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214241PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453481PMC
April 2019
1 Read

A Three-Site Clinical Feasibility Study of a Flexible Functional Electrical Stimulation System to Support Functional Task Practice for Upper Limb Recovery in People With Stroke.

Front Neurol 2019 20;10:227. Epub 2019 Mar 20.

Centre for Biostatistics, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.

Of those people who survive a stroke, only between 40 and 70% regain upper limb dexterity. A number of reviews have suggested that functional electrical stimulation (FES) may have a beneficial effect on upper limb motor recovery. In light of the promise offered by FES and the limitations with current systems a new system was developed (FES-UPP) to support people with stroke (PwS) to practice a range of voluntary controlled, FES-assisted functional activities. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00227
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http://dx.doi.org/10.3389/fneur.2019.00227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436422PMC
March 2019
4 Reads

Somatosensory Deficits After Ischemic Stroke.

Stroke 2019 Apr 4:STROKEAHA118023750. Epub 2019 Apr 4.

From the Department of Neurology, University Medical Center Hamburg-Eppendorf, Germany (S.S.K., E.S., B.C., C.G., G.T.).

Background and Purpose- About 50% to 80% of stroke survivors present with somatosensory deficits. Somatosensory deficits because of an ischemic stroke are determined by the infarct location. However, a detailed understanding of the long-term effect of lesions on somatosensory performance is lacking. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023750DOI Listing
April 2019
3 Reads

Systematic Review Investigating the Effects of Nonpharmacological Interventions During Sleep to Enhance Physical Rehabilitation Outcomes in People With Neurological Diagnoses.

Neurorehabil Neural Repair 2019 Apr 2:1545968319840288. Epub 2019 Apr 2.

1 University of Maryland School of Medicine, Baltimore, MD, USA.

Objective: Conduct a systematic review of nonpharmacological interventions applied during sleep to enhance physical rehabilitation outcomes of individuals with a neurological diagnosis.

Data Sources: Three online databases were searched for original research.

Study Selection: Intervention studies were included that used outcome measures of impairment, activity, and/or participation. Read More

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http://dx.doi.org/10.1177/1545968319840288DOI Listing
April 2019
5 Reads

Executive functions in the elderly with mild cognitive impairment: a systematic review on motor and cognitive inhibition, conflict control and cognitive flexibility.

Aging Ment Health 2019 Apr 2:1-18. Epub 2019 Apr 2.

b Dipartimento di Psicologia Dinamica e Clinica, Università di Roma Sapienza , Rome , Italy.

Background: Mild Cognitive Impairment (MCI) is a syndrome characterised by mild cognitive decline, on one or more domains, but which does not compromise daily functions. Several studies have investigated the relationship between MCI and deficit in executive functions (EFs) but, unlike robust evidence in the mnestic domain, the nature of executive deficits in the MCI population remains uncertain.

Objectives: This systematic review aims to evaluate EFs in patients with MCI, considering inhibition (motor and cognitive), conflict control and cognitive flexibility. Read More

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http://dx.doi.org/10.1080/13607863.2019.1584785DOI Listing
April 2019
2 Reads

Structural and functional connectivity correlates with motor impairment in chronic supratentorial stroke: a multimodal magnetic resonance imaging study.

Neuroreport 2019 May;30(7):526-531

Department of Physical Medicine and Rehabilitation, Veterans Health Service Medical Center.

The aim of this study was to identify differences in structural and functional brain connectivity between poststroke mild and severe motor impairment. Twenty-four chronic stroke patients who underwent resting-state functional MRI and diffusion tensor image were retrospectively included. All patients were classified into two groups (mild motor impairment: 11 patients and severe motor impairment: 13 patients) according to their Fugl-Meyer motor assessment score. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001247DOI Listing
May 2019
2 Reads

Clinical improvement with intensive robot-assisted arm training in chronic stroke is unchanged by supplementary tDCS.

Restor Neurol Neurosci 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurology, Beth Israel Deaconess Medical Center, Berenson-Allen Center for Noninvasive Brain Stimulation, and Harvard Medical School, Boston, MA, USA.

Background: Intensive robot-assisted arm training in the chronic phase of stroke recovery can lead to clinical improvement. Combinatorial therapeutic approaches are sought to further optimize stroke recovery. Transcranial direct current stimulation (tDCS) is one candidate to combine with robotic training, as transient increases in excitability and improvements in motor behavior have separately been reported. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/RNN-180869DOI Listing
March 2019
6 Reads

Impaired decision-making and time perception in individuals with stroke: Behavioral and neural correlates.

Rev Neurol (Paris) 2019 Mar 25. Epub 2019 Mar 25.

Neuro-innovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Parnaíba, Brazil; The Northeast Biotechnology Network, Federal University of Piauí, Teresina-PI, Brazil.

Several studies have demonstrated that stroke subjects present impairment of functions related to decision-making and timing, involving the information processing in the neural circuits of the cerebellum in association with the prefrontal cortex. This review is aimed to identify the gaps, and demonstrate a better understanding of decision-making and timing functions in the patients with stroke. Electronic literature database was searched and the findings of relevant studies were used to explore the mechanisms of decision-making and timing in patients with stroke, as well as the circuit connections in timing mediated by prefrontal cortex and cerebellum. Read More

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http://dx.doi.org/10.1016/j.neurol.2018.10.004DOI Listing
March 2019
1 Read

Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier.

Sci Rep 2019 Mar 27;9(1):5280. Epub 2019 Mar 27.

Center of Excellence for Aging & Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612, USA.

Convincing evidence demonstrated impairment of the blood-spinal cord barrier (BSCB) in Amyotrophic Lateral Sclerosis (ALS), mainly by endothelial cell (EC) alterations. Replacing damaged ECs by cell transplantation is a potential barrier repair strategy. Recently, we showed that intravenous (iv) administration of human bone marrow CD34 (hBM34) cells into symptomatic ALS mice benefits BSCB restoration and postpones disease progression. Read More

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http://dx.doi.org/10.1038/s41598-019-41747-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437219PMC
March 2019
1 Read

Baihui Point Laser Acupuncture Ameliorates Cognitive Impairment, Motor Deficit, and Neuronal Loss Partly via Antioxidant and Anti-Inflammatory Effects in an Animal Model of Focal Ischemic Stroke.

Authors:
Jinatta Jittiwat

Evid Based Complement Alternat Med 2019 24;2019:1204709. Epub 2019 Feb 24.

Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand.

Stroke is recognized as one of the most dangerous killer diseases in Thailand and other countries worldwide. The development of a novel strategy for treating stroke patients is therefore urgently required. The present study investigated the effect of laser acupuncture at the Baihui point on cognitive and functional recovery, neuronal loss, antioxidant enzyme activities, and interleukin-6 (IL-6) activity in the hippocampus in an animal model of focal ischemic stroke. Read More

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http://dx.doi.org/10.1155/2019/1204709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409074PMC
February 2019
1 Read

The Relationship Between Enhanced Reticulospinal Outflow and Upper Limb Function in Chronic Stroke Patients.

Neurorehabil Neural Repair 2019 Mar 27:1545968319836233. Epub 2019 Mar 27.

3 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Background: Recent evidence from both monkey and human studies suggests that the reticulospinal tract may contribute to recovery of arm and hand function after stroke. In this study, we evaluated a marker of reticulospinal output in stroke survivors with varying degrees of motor recovery.

Methods: We recruited 95 consecutive stroke patients presenting 6 months to 12 years after their index stroke, and 19 heathy control subjects. Read More

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http://dx.doi.org/10.1177/1545968319836233DOI Listing
March 2019
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Can robot-based measurements improve prediction of motor performance after robot-assisted upper-limb rehabilitation in patients with moderate-to-severe sub-acute stroke?

Restor Neurol Neurosci 2019 Mar 21. Epub 2019 Mar 21.

CRF Les Trois Soleils, Médecine Physique et de Réadaptation, Unité de Rééducation Neurologique, Boissise-Le-Roi (77), France.

Purpose: Patients with moderate-to-severe stroke-related upper limb impairment can benefit from repetitive robot-assisted training. However, predicting motor performance in these patients from baseline measurements, including robot-based parameters would help clinicians to provide optimal treatments for each individual.

Methods: Forty-six patients with sub-acute stroke underwent a 16-session upper limb rehabilitation combining usual care and robotic therapy. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/RNN-180892DOI Listing
March 2019
4 Reads

Compensation Strategies for Gait Impairments in Parkinson Disease: A Review.

JAMA Neurol 2019 Mar 25. Epub 2019 Mar 25.

Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Centre, Nijmegen, the Netherlands.

Importance: Patients with Parkinson disease can use a wide variety of strategies to compensate for their gait impairments. Examples include walking while rhythmically bouncing a ball, crossing the legs when walking, or stepping over an inverted cane. An overview and classification of the many available compensation strategies may contribute to understanding their underlying mechanisms and developing focused rehabilitation techniques. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0033DOI Listing
March 2019
2 Reads

Hand function and type of grasp used by chronic stroke individuals in actual environment.

Top Stroke Rehabil 2019 Mar 23:1-8. Epub 2019 Mar 23.

a Department of Physical Therapy , Universidade do Estado de Santa Catarina , Florianópolis , Brazil.

Background: Knowledge of paretic upper limb (UL) use in the actual environment is crucial for defining treatment strategies that are likely to enhance performance.

Objective: To quantify the hand function and type of grasp performed in the actual environment following stroke and determine if any differences in hand use are dependent on the degree of motor impairment.

Method: This cross-sectional study enrolled 41 participants with chronic hemiparesis classified as having either mild (11), moderate (20), or severe (10) UL impairment. Read More

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https://www.tandfonline.com/doi/full/10.1080/10749357.2019.1
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http://dx.doi.org/10.1080/10749357.2019.1591037DOI Listing
March 2019
5 Reads

How does upper extremity Fugl-Meyer motor score relate to resting-state EEG in chronic stroke? A power spectral density analysis.

Clin Neurophysiol 2019 May 2;130(5):856-862. Epub 2019 Feb 2.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam Neuroscience, de Boelelaan 1117, Amsterdam, the Netherlands. Electronic address:

Objective: We investigated the potential added value of high-density resting-state EEG by addressing differences with healthy individuals and associations with Fugl-Meyer motor assessment of the upper extremity (FM-UE) scores in chronic stroke.

Methods: Twenty-one chronic stroke survivors with initial upper limb paresis and eleven matched controls were included. Group differences regarding resting-state EEG parameters (Delta Alpha ratio (DAR) and pairwise-derived Brain Symmetry Index (BSI)) and associations with FM-UE were investigated, as well as lateralization of BSI and the value of different frequency bands. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.007DOI Listing
May 2019
1 Read

Does severity of motor impairment affect reactive adaptation and fall-risk in chronic stroke survivors?

J Neuroeng Rehabil 2019 Mar 22;16(1):43. Epub 2019 Mar 22.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, 1919, W Taylor St, (M/C 898), Chicago, IL, 60612, USA.

Background: A single-session of slip-perturbation training has shown to induce long-term fall risk reduction in older adults. Considering the spectrum of motor impairments and deficits in reactive balance after a cortical stroke, we aimed to determine if chronic stroke survivors could acquire and retain reactive adaptations to large slip-like perturbations and if these adaptations were dependent on severity of motor impairment.

Methods: Twenty-six chronic stroke participants were categorized into high and low-functioning groups based on their Chedoke-McMaster-Assessment scores. Read More

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http://dx.doi.org/10.1186/s12984-019-0510-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429795PMC
March 2019
6 Reads

Ipsilesional Mu Rhythm Desynchronization and Changes in Motor Behavior Following Post Stroke BCI Intervention for Motor Rehabilitation.

Front Neurosci 2019 6;13:53. Epub 2019 Mar 6.

Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States.

Loss of motor function is a common deficit following stroke insult and often manifests as persistent upper extremity (UE) disability which can affect a survivor's ability to participate in activities of daily living. Recent research suggests the use of brain-computer interface (BCI) devices might improve UE function in stroke survivors at various times since stroke. This randomized crossover-controlled trial examines whether intervention with this BCI device design attenuates the effects of hemiparesis, encourages reorganization of motor related brain signals (EEG measured sensorimotor rhythm desynchronization), and improves movement, as measured by the Action Research Arm Test (ARAT). Read More

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http://dx.doi.org/10.3389/fnins.2019.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417367PMC
March 2019
2 Reads

Boosting robot-assisted rehabilitation of stroke hemiparesis by individualized selection of upper limb movements - a pilot study.

J Neuroeng Rehabil 2019 Mar 20;16(1):42. Epub 2019 Mar 20.

School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK.

Background: Intensive robot-assisted training of the upper limb after stroke can reduce motor impairment, even at the chronic stage. However, the effectiveness of practice for recovery depends on the selection of the practised movements. We hypothesized that rehabilitation can be optimized by selecting the movements to be practiced based on the trainee's performance profile. Read More

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http://dx.doi.org/10.1186/s12984-019-0513-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425657PMC
March 2019
2 Reads

Characteristics of the shoulder in patients following acute stroke: a case series.

Top Stroke Rehabil 2019 Mar 20:1-8. Epub 2019 Mar 20.

a School of Physiotherapy, Faculty of Health Sciences , Curtin University , Perth , Australia.

Background: Stroke can result in pain and loss of motor control in the hemiplegic shoulder, and while prevention of secondary changes is likely to be the most effective management, there is limited evidence directing clinicians towards the most at-risk patients.

Objectives: The aim of this case series was to investigate the presentation of shoulder pain, motor impairment, shoulder passive range of motion (PROM) and alignment of the hemiplegic shoulder following acute stroke.

Methods: This study reported data that was collected as part of a pilot randomized controlled trial investigating kinesiology taping of the hemiplegic shoulder. Read More

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http://dx.doi.org/10.1080/10749357.2019.1590973DOI Listing
March 2019
2 Reads

Proprioception and motor performance after stroke: An examination of diffusion properties in sensory and motor pathways.

Hum Brain Mapp 2019 Mar 19. Epub 2019 Mar 19.

Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Proprioceptive and motor impairments commonly occur after stroke. Relationships between corticospinal tract (CST) fractional anisotropy (FA) and motor recovery have been identified. However, the relationship between sensory tract microstructure and proprioceptive recovery remains unexplored. Read More

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http://dx.doi.org/10.1002/hbm.24574DOI Listing
March 2019
1 Read

Myoelectric Computer Interface Training for Reducing Co-Activation and Enhancing Arm Movement in Chronic Stroke Survivors: A Randomized Trial.

Neurorehabil Neural Repair 2019 Apr 19;33(4):284-295. Epub 2019 Mar 19.

1 Northwestern University, Chicago, IL, USA.

Background: Abnormal muscle co-activation contributes to impairment after stroke. We developed a myoelectric computer interface (MyoCI) training paradigm to reduce abnormal co-activation. MyoCI provides intuitive feedback about muscle activation patterns, enabling decoupling of these muscles. Read More

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http://dx.doi.org/10.1177/1545968319834903DOI Listing
April 2019
1 Read

Self-efficacy and Reach Performance in Individuals With Mild Motor Impairment Due to Stroke.

Neurorehabil Neural Repair 2019 Apr 18;33(4):319-328. Epub 2019 Mar 18.

3 University of Southern California, Los Angeles, CA, USA.

Background: Persistent deficits in arm function are common after stroke. An improved understanding of the factors that contribute to the performance of skilled arm movements is needed. One such factor may be self-efficacy (SE). Read More

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http://dx.doi.org/10.1177/1545968319836231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462237PMC
April 2019
3 Reads

Perinatal stroke syndromes: Similarities and diversities in aetiology, outcome and management.

Eur J Paediatr Neurol 2019 Feb 27. Epub 2019 Feb 27.

CHU Saint-Étienne, French Centre for Paediatric Stroke, Paediatric Physical and Rehabilitation Medicine Department, INSERM, CIC 1408, F-42055, Saint-Étienne, France; INSERM, U1059 Sainbiose, Univ Saint-Étienne, Univ Lyon, F-42023, Saint-Étienne, France. Electronic address:

With a birth-prevalence of 37-67/100,000 (mostly term-born), perinatal stroke encompasses distinct disease-states with diverse causality, mechanism, time of onset, mode of presentation and outcome. Neonatal primary haemorrhagic stroke and ischemic events (also divided into neonatal arterial ischemic stroke and neonatal cerebral sinus venous thrombosis) that manifest soon after birth are distinguished from presumed perinatal - ischemic or haemorrhagic - stroke. Signs of the latter become apparent only beyond the neonatal period, most often with motor asymmetry or milestones delay, and occasionally with seizures. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.02.013DOI Listing
February 2019
1 Read

Early prediction of long-term tactile object recognition performance after sensorimotor stroke.

Cortex 2019 Feb 7;115:264-279. Epub 2019 Feb 7.

Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:

Until now tactile agnosia has been reported only in small, but detailed cross-sectional case studies. Here we show that multi-voxel pattern analysis (MVPA) of early diffusion-weighted lesion maps can be used to accurately predict long-term recovery of tactile object recognition (TOR) in 35 subjects with varying hand skill impairment and associated specific daily activity limitation after cortical sensori-motor stroke. Multiple regression analysis revealed the essentially dysfunctional subprocesses for object recognition in the specifically impaired subjects, i. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.01.018DOI Listing
February 2019
2 Reads

Lesions Responsible for Impaired Visual Perception in Poststroke Patients Using Voxel-Based Lesion Symptom Mapping.

Clin Anat 2019 Mar 14. Epub 2019 Mar 14.

Department of Rehabilitation Medicine, Bundang Jesaeng General Hospital, Seoungnam-si, Republic of Korea.

We aimed to clarify the clinical characteristics that affect visual perception (VP) and elucidate lesion locations correlated with impaired VP. We reviewed 61 patients with stroke. Clinical assessments of a motor-free VP test were used to evaluate VP after stroke. Read More

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http://dx.doi.org/10.1002/ca.23373DOI Listing
March 2019
1 Read

Does Fractional Anisotropy Predict Motor Imagery Neurofeedback Performance in Healthy Older Adults?

Front Hum Neurosci 2019 28;13:69. Epub 2019 Feb 28.

Neuropsychology Lab, Department of Psychology, University of Oldenburg, Oldenburg, Germany.

Motor imagery neurofeedback training has been proposed as a potential add-on therapy for motor impairment after stroke, but not everyone benefits from it. Previous work has used white matter integrity to predict motor imagery neurofeedback aptitude in healthy young adults. We set out to test this approach with motor imagery neurofeedback that is closer to that used for stroke rehabilitation and in a sample whose age is closer to that of typical stroke patients. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403184PMC
February 2019
3 Reads

LSVT BIG in late stroke rehabilitation: A single-case experimental design study.

Can J Occup Ther 2019 Mar 12:8417419832951. Epub 2019 Mar 12.

Background.: Late stroke rehabilitation interventions often target impairment with limited carryover to daily occupation.

Purpose. Read More

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http://dx.doi.org/10.1177/0008417419832951DOI Listing
March 2019
2 Reads

Provisional Tic Disorder is not so transient.

Sci Rep 2019 Mar 8;9(1):3951. Epub 2019 Mar 8.

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.

Motor and vocal tics are common in childhood. The received wisdom among clinicians is that for most children the tics are temporary, disappearing within a few months. However, that common clinical teaching is based largely on biased and incomplete data. Read More

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http://dx.doi.org/10.1038/s41598-019-40133-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408476PMC
March 2019
2 Reads

Applying LDA-based pattern recognition to predict isometric shoulder and elbow torque generation in individuals with chronic stroke with moderate to severe motor impairment.

J Neuroeng Rehabil 2019 Mar 5;16(1):35. Epub 2019 Mar 5.

Department of Physical Therapy and Human Movement Sciences, Northwestern University, 645 N Michigan Ave, Suite 1100, Chicago, IL, 60611, USA.

Background: Abnormal synergy is a major stroke-related movement impairment that presents as an unintentional contraction of muscles throughout a limb. The flexion synergy, consisting of involuntary flexion coupling of the paretic elbow, wrist, and fingers, is caused by and proportional to the amount of shoulder abduction effort and limits reaching function. A wearable exoskeleton capable of predicting movement intent could augment abduction effort and therefore reduce the negative effects of distal joint flexion synergy. Read More

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http://dx.doi.org/10.1186/s12984-019-0504-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399836PMC
March 2019
6 Reads

Predicting Motor Outcomes in Stroke Patients Using Diffusion Spectrum MRI Microstructural Measures.

Front Neurol 2019 18;10:72. Epub 2019 Feb 18.

Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States.

Improved understanding of neuroimaging signal changes and their relation to patient outcomes after ischemic stroke is needed to improve ability to predict motor improvement and make therapy recommendations. The posterior limb of the internal capsule (PLIC) is a hub of afferent and efferent motor signaling and this work proposes new, image-based methods for prognosis based on interhemispheric differences in the PLIC. In this work, nine acute supratentorial ischemic stroke patients with motor impairment received a baseline, 203-direction diffusion brain MRI and a clinical assessment 3-12 days post-stroke and were compared to nine age-matched healthy controls. Read More

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http://dx.doi.org/10.3389/fneur.2019.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387951PMC
February 2019
2 Reads

Effects of camera-based mirror visual feedback therapy for patients who had a stroke and the neural mechanisms involved: protocol of a multicentre randomised control study.

BMJ Open 2019 Mar 3;9(3):e022828. Epub 2019 Mar 3.

Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Introduction: As a combination of visual stimulation and motor imagery, mirror visual feedback (MVF) is an effective treatment for motor impairment after stroke; however, few studies have investigated its effects on relevant cognitive processes such as visual perception and motor imagery. Camera-based MVF (camMVF) overcomes the intrinsic limitations of real mirrors and is recognised as an optimal setup. This study aims to investigate the effects of camMVF as an adjunct treatment for stroke patients, compare camMVF outcomes with those of conventional therapy and elucidate neural mechanisms through which MVF influences cognition and brain networks. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02282
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http://dx.doi.org/10.1136/bmjopen-2018-022828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443084PMC
March 2019
5 Reads

Nonpharmacological rehabilitation interventions for motor and cognitive outcomes following pediatric stroke: a systematic review.

Eur J Pediatr 2019 Apr 27;178(4):433-454. Epub 2019 Feb 27.

Parkwood Institute Research, Lawson Health Research Institute, Parkwood Institute, London, ON, Canada.

The aim of this review was to evaluate the evidence for nonpharmacological rehabilitation interventions for motor and cognitive impairment following pediatric stroke. A literature search was conducted using multiple scientific databases. Studies were included if (1) the study population was > 50% pediatric (< 18 years) stroke, (2) a diagnosis of stroke was explicitly stated, (3) there were ≥ 3 pediatric stroke participants included in the study sample, and (4) motor or cognitive outcome measures were used to assess effect of treatment. Read More

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http://dx.doi.org/10.1007/s00431-019-03350-7DOI Listing
April 2019
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Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation.

Ann Neurol 2019 Apr 19;85(4):502-513. Epub 2019 Mar 19.

Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD.

Objective: Patients with chronic stroke have been shown to have failure to release interhemispheric inhibition (IHI) from the intact to the damaged hemisphere before movement execution (premovement IHI). This inhibitory imbalance was found to correlate with poor motor performance in the chronic stage after stroke and has since become a target for therapeutic interventions. The logic of this approach, however, implies that abnormal premovement IHI is causal to poor behavioral outcome and should therefore be present early after stroke when motor impairment is at its worst. Read More

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http://dx.doi.org/10.1002/ana.25452DOI Listing
April 2019
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Translation and Initial Validation of the Chinese Version of the Action Research Arm Test in People with Stroke.

Biomed Res Int 2019 21;2019:5416560. Epub 2019 Jan 21.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.

Purpose: This study aimed to translate the English version of the Action Research Arm Test (ARAT) into Chinese and to evaluate the initial validation of the Chinese version (C-ARAT) in patients with a first stroke.

Methods: An expert group translated the original ARAT from English into Chinese using a forward-backward procedure. Forty-four patients (36 men and 8 women) aged 22-80 years with a first stroke were enrolled in this study. Read More

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https://www.hindawi.com/journals/bmri/2019/5416560/
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http://dx.doi.org/10.1155/2019/5416560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363239PMC
January 2019
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The effectiveness of somatosensory retraining for improving sensory function in the arm following stroke: a systematic review.

Clin Rehabil 2019 Feb 25:269215519829795. Epub 2019 Feb 25.

1 Occupational Therapy, School of Allied Health, Human Services and Sport, College of Science, Health and Engineering, La Trobe University, Melbourne, VIC, Australia.

Objective:: The aim of this study was to evaluate if somatosensory retraining programmes assist people to improve somatosensory discrimination skills and arm functioning after stroke.

Data Sources:: Nine databases were systematically searched: Medline, Cumulative Index to Nursing and Allied Health Literature, PsychInfo, Embase, Amed, Web of Science, Physiotherapy Evidence Database, OT seeker, and Cochrane Library.

Review Methods:: Studies were included for review if they involved (1) adult participants who had somatosensory impairment in the arm after stroke, (2) a programme targeted at retraining somatosensation, (3) a primary measure of somatosensory discrimination skills in the arm, and (4) an intervention study design (e. Read More

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http://dx.doi.org/10.1177/0269215519829795DOI Listing
February 2019
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Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon.

Authors:
Steven R Zeiler

Curr Neurol Neurosci Rep 2019 Feb 20;19(3):13. Epub 2019 Feb 20.

Department of Neurology, Johns Hopkins, Phipps 443 600 N. Wolfe Street, Baltimore, MD, 21287, USA.

Purpose Of Review: Studies in humans and animal models show that most recovery from impairment occurs in the first 1-3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short-lived "sensitive period" of post-stroke plasticity defined by unique genetic, physiological, and structural events. Unfortunately, rehabilitative interventions in humans have not been able to exploit this sensitive period similar to that seen in animal models. Read More

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http://dx.doi.org/10.1007/s11910-019-0927-xDOI Listing
February 2019
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Impaired posture, movement preparation, and execution during both paretic and nonparetic reaching following stroke.

J Neurophysiol 2019 Apr 20;121(4):1465-1477. Epub 2019 Feb 20.

Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine , Baltimore, Maryland.

Posture and movement planning, preparation, and execution of a goal-directed reaching movement are impaired in individuals with stroke. No studies have shown whether the deficits are generally impaired or are specific to the lesioned hemisphere/paretic arm. This study utilized StartReact (SR) responses elicited by loud acoustic stimuli (LAS) to investigate the preparation and execution of anticipatory postural adjustments (APAs) and reach movement response during both paretic and nonparetic arm reaching in individuals with stroke and in age-matched healthy controls. Read More

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http://dx.doi.org/10.1152/jn.00694.2018DOI Listing

Intensive upper limb neurorehabilitation in chronic stroke: outcomes from the Queen Square programme.

J Neurol Neurosurg Psychiatry 2019 May 15;90(5):498-506. Epub 2019 Feb 15.

The National Hospital for Neurology and Neurosurgery, London, UK.

Objective: Persistent difficulty in using the upper limb remains a major contributor to physical disability post-stroke. There is a nihilistic view about what clinically relevant changes are possible after the early post-stroke phase. The Queen Square Upper Limb Neurorehabilitation programme delivers high-quality, high-dose, high-intensity upper limb neurorehabilitation during a 3-week (90 hours) programme. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319954DOI Listing
May 2019
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Language as a Predictor of Motor Recovery: The Case for a More Global Approach to Stroke Rehabilitation.

Neurorehabil Neural Repair 2019 Mar 13;33(3):167-178. Epub 2019 Feb 13.

3 Curtin University, Perth, Western Australia, Australia.

Stroke is the third leading cause of death in the developed world and the primary cause of adult disability. The most common site of stroke is the middle cerebral artery (MCA), an artery that supplies a range of areas involved in both language and motor function. As a consequence, many stroke patients experience a combination of language and motor deficits. Read More

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http://dx.doi.org/10.1177/1545968319829454DOI Listing
March 2019
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Predictors of upper limb spasticity after stroke? A systematic review and meta-analysis.

Physiotherapy 2019 Jan 11. Epub 2019 Jan 11.

School of Health Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. Electronic address:

Objective: To determine the predictive markers for the occurrence of upper limb spasticity in the first 12 months after stroke.

Data Sources: A systematic review was undertaken of the databases MEDLINE, EMBASE, CINAHL and PEDRO to 31st December 2017.

Study Selection: Non-experimental or experimental studies that included a control group with spasticity who did not receive an experimental intervention which investigated at least one variable (explanatory variable) measured at baseline against the development (or not) of spasticity at a future time point within 12 months post stroke were selected independently by two reviewers. Read More

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http://dx.doi.org/10.1016/j.physio.2019.01.004DOI Listing
January 2019
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Impact of physical activity in vascular cognitive impairment (AFIVASC): study protocol for a randomised controlled trial.

Trials 2019 Feb 11;20(1):114. Epub 2019 Feb 11.

Faculdade de Motricidade Humana, Universidade de Lisboa, CIPER - Centro Interdisciplinar de Estudo da Performance Humana, Lisbon, Portugal.

Background: Cognitive impairment and cerebrovascular pathology are both frequent with ageing. Cognitive impairment due to vascular pathology of the brain, termed vascular cognitive impairment (VCI), is one of the most frequent causes of cognitive impairment in elderly subjects. Thus far, VCI has no specific pharmacological treatment. Read More

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http://dx.doi.org/10.1186/s13063-019-3174-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371566PMC
February 2019
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The Influence of Primary Motor Cortex Inhibition on Upper Limb Impairment and Function in Chronic Stroke: A Multimodal Study.

Neurorehabil Neural Repair 2019 Feb;33(2):130-140

1 The University of Auckland, Auckland, New Zealand.

Background: Stroke is a leading cause of adult disability owing largely to motor impairment and loss of function. After stroke, there may be abnormalities in γ-aminobutyric acid (GABA)-mediated inhibitory function within primary motor cortex (M1), which may have implications for residual motor impairment and the potential for functional improvements at the chronic stage.

Objective: To quantify GABA neurotransmission and concentration within ipsilesional and contralesional M1 and determine if they relate to upper limb impairment and function at the chronic stage of stroke. Read More

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http://dx.doi.org/10.1177/1545968319826052DOI Listing
February 2019
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Dissociating nNOS (Neuronal NO Synthase)-CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity.

Stroke 2019 Mar;50(3):728-737

From the Institution of Stem Cells and Neuroregeneration (H.-Y.N., Y.-X.S., Y.-H.L., B.C., D.-L.W., Y.Z., J.D., H.-Y.L., K.X., T.-Y.L., L.C., H.-Y.W., C.-X.L., D.-Y.Z.), Nanjing Medical University, China.

Background and Purpose- Stroke is a major public health concern worldwide. Although clinical treatments have improved in the acute period after stroke, long-term therapeutics remain limited to physical rehabilitation in the delayed phase. This study is aimed to determine whether nNOS (neuronal NO synthase)-CAPON (carboxy-terminal postsynaptic density-95/discs large/zona occludens-1 ligand of nNOS) interaction may serve as a new therapeutic target in the delayed phase for stroke recovery. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022647DOI Listing
March 2019
3 Reads