85,788 results match your criteria Stroke Ischemic


Socioeconomic gap between neighborhoods of Budapest: Striking impact on stroke and possible explanations.

PLoS One 2019 20;14(2):e0212519. Epub 2019 Feb 20.

Semmelweis University, Department of Neurology, Budapest, Hungary.

Introduction: Hungary has a single payer health insurance system offering free healthcare for acute cerebrovascular disorders. Within the capital, Budapest, however there are considerable microregional socioeconomic differences. We hypothesized that socioeconomic deprivation reflects in less favorable stroke characteristics despite universal access to care. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212519PLOS
February 2019

Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation: A Randomized Clinical Trial From the Cardiothoracic Surgical Trials Network

Circ Cardiovasc Qual Outcomes 2018 Nov 14;11(11):13. Epub 2018 Nov 14.

Background: The CTSN (Cardiothoracic Surgical Trials Network) recently reported no difference in left ventricular end-systolic volume index or in survival at 2 years between patients with severe ischemic mitral regurgitation (MR) randomized to mitral valve repair or replacement. However, replacement provided more durable correction of MR and fewer cardiovascular readmissions. Yet, costeffectiveness outcomes have not been addressed. Read More

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November 2018

[Multiple ischemic stroke in Osler-Rendu-Weber disease].

Ideggyogy Sz 2019 Jan;72(1-2):65-70

Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ, Neurológiai Klinika, Szeged.

Hereditary hemorrhagic teleangiectasia (HHT, Osler-Rendu-Weber disease) is an autosomal dominantly inherited disorder caused by the mutation of several possible genes and characterized by malformations of the arteriovenous system in multiple organs. The clinical diagnosis is based on the Curaçao criteria ((1) spontaneous, recurrent epistaxis; (2) teleangiectasias in characteristic sites (lips, oral cavity, nose, fingers); (3) visceral lesions (gastrointestinal, pulmonary, cerebral, spinal); (4) affected first degree relative). The aim of this study is to present the first genetically confirmed Hungarian case of hereditary hemorrhagic teleangiectasia with multiple ischemic strokes. Read More

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http://dx.doi.org/10.18071/https://doi.org/10.18071/isz.72.0065DOI Listing
January 2019

Fortifying Angiogenesis in Ischemic Muscle with FGF9-Loaded Electrospun Poly(Ester Amide) Fibers.

Adv Healthc Mater 2019 Feb 20:e1801294. Epub 2019 Feb 20.

Robarts Research Institute, Department of Medicine (Cardiology), Department of Biochemistry, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London Health Sciences Centre, 339 Windermere Rd, London, Ontario, N6A 5A5, Canada.

Delivery of angiogenic growth factors lessens ischemia in preclinical models but has demonstrated little benefit in patients with peripheral vascular disease. Augmenting the wrapping of nascent microvessels by mural cells constitutes an alternative strategy to regenerating a functional microvasculature, particularly if integrated with a sustained delivery platform. Herein, electrospun poly(ester amide) (PEA) nanofiber mats are fabricated for delivering a mural cell-targeting factor, fibroblast growth factor 9 (FGF9). Read More

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http://dx.doi.org/10.1002/adhm.201801294DOI Listing
February 2019

Surgical treatment of a left ventricular apical thrombus via robotic surgery.

J Card Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Cardiovascular Surgery, Health Sciences University Gülhane Training and Research Hospital, Ankara, Turkey.

Left ventriculotomy for thrombus removal is usually associated with a high incidence of cardiac arrhythmias and decreased ejection fraction. A 51-year-old male patient was admitted to the emergency department with loss of consciousness. Transthoracic echocardiography revealed a 20 × 24-mm left ventricular apical nonpedunculated thrombus with normal ejection fraction. Read More

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http://dx.doi.org/10.1111/jocs.14000DOI Listing
February 2019

Homocysteine and Small Vessel Stroke: A Mendelian Randomization Analysis.

Ann Neurol 2019 Feb 19. Epub 2019 Feb 19.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Objective: Trials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiologic studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS). We assessed whether circulating tHcy and B vitamin levels are selectively associated with SVS, but not other stroke subtypes, using Mendelian randomization. Read More

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http://dx.doi.org/10.1002/ana.25440DOI Listing
February 2019

Effects of cold temperature and snowfall on stroke mortality: A case-crossover analysis.

Environ Int 2019 Feb 20;126:89-95. Epub 2019 Feb 20.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Institut national de santé publique du Québec, Montreal, Quebec, Canada; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada. Electronic address:

Background: We sought to determine if cold temperature and snowfall are independently associated with stroke mortality, and whether effects differ between hemorrhagic and ischemic stroke.

Materials And Methods: We conducted a case-crossover study of 13,201 stroke deaths utilizing weather records between the months of November and April for Quebec, Canada from 1981 to 2015. We compared exposure to cold temperature and snowfall with controls days when stroke death did not occur. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.031DOI Listing
February 2019

Real-World Comparison of Classes IC and III Antiarrhythmic Drugs as an Initial Rhythm Control Strategy in Newly Diagnosed Atrial Fibrillation: From the TREAT-AF Study.

JACC Clin Electrophysiol 2019 Feb 1;5(2):231-241. Epub 2018 Nov 1.

Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Department of Medicine, Stanford University School of Medicine, Stanford, California; Center for Digital Health, Stanford University School of Medicine, Stanford, California. Electronic address:

Objectives: In this study the authors investigated effectiveness and safety of an initial treatment strategy with class IC or class III antiarrhythmic drugs (AAD) for newly diagnosed atrial fibrillation (AF) or atrial flutter (AFL).

Background: There is limited evidence to guide optimal AAD selection for rhythm control in newly diagnosed AF/AFL.

Methods: Using data from TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF), the authors performed a retrospective cohort study of patients with AF/AFL from 2004 to 2014 and class IC or class III AAD prescription within 90 days following diagnosis. Read More

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http://dx.doi.org/10.1016/j.jacep.2018.08.025DOI Listing
February 2019

Double Filtration During Carotid Artery Stenting Using a Novel Post-Dilation Balloon With Integrated Embolic Protection.

JACC Cardiovasc Interv 2019 Feb;12(4):395-403

Department of Angiology, Universitats Herzzentrum Freiburg-Bad Krozingen, Bad Krozingen, Germany.

Objectives: This study evaluated the safety and performance of the Paladin System, a novel angioplasty balloon with an integrated embolic protection filter designed to increase embolic protection during post-dilation.

Background: The risk of major adverse events during carotid artery stenting (CAS) is equivalent to carotid endarterectomy. However, the risk of minor stroke remains higher with CAS. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.11.039DOI Listing
February 2019

Why a Threshold Case Volume in Complex Systems Such as Thrombectomy in Stroke Care Is Inadequate to Discriminate Quality Outcomes.

JACC Cardiovasc Interv 2019 Feb;12(4):392-394

Ochsner Clinical School, Ochsner Medical Center, New Orleans, Louisiana. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2018.12.002DOI Listing
February 2019

Higher Annual Operator Volume Is Associated With Better Reperfusion Rates in Stroke Patients Treated by Mechanical Thrombectomy: The ETIS Registry.

JACC Cardiovasc Interv 2019 Feb;12(4):385-391

Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Versailles, France; Versailles Saint-Quentin en Yvelines and Paris Saclay University, Versailles, France; INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France. Electronic address:

Objectives: The aim of this study was to determine whether individual operator characteristics have an impact on reperfusion and procedural complication rates.

Background: Mechanical thrombectomy (MT) is a Level IA treatment in acute ischemic stroke (AIS) patients. The operator's effect has been found to be an independent predictor for clinical outcome and technical performance in interventional cardiology. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19368798183243
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http://dx.doi.org/10.1016/j.jcin.2018.12.007DOI Listing
February 2019
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Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats.

CNS Neurosci Ther 2019 Feb 19. Epub 2019 Feb 19.

Shanghai Jiao Tong Affiliated Sixth People's Hospital, Neuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Introduction: Dl-3-N-butylphthalide (NBP), a small molecule drug used clinically in the acute phase of ischemic stroke, has been shown to improve functional recovery and promote angiogenesis and collateral vessel circulation after experimental cerebral ischemia. However, the underlying molecular mechanism is unknown.

Aims: To explore the potential molecular mechanism of angiogenesis induced by NBP after cerebral ischemia. Read More

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http://doi.wiley.com/10.1111/cns.13104
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http://dx.doi.org/10.1111/cns.13104DOI Listing
February 2019
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High-Throughput Profiling of Circulating Antibody Signatures for Stroke Diagnosis Using Small Volumes of Whole Blood.

Neurotherapeutics 2019 Feb 19. Epub 2019 Feb 19.

Valtari Bio Incorporated, Morgantown, West Virginia, USA.

Accurate stroke recognition during triage can streamline care and afford patients earlier access to life-saving interventions. However, the tools currently available to clinicians for prehospital and early in-hospital identification of stroke are limited. The peripheral immune system is intricately involved in stroke pathology and thus may be targetable for the development of immunodiagnostics. Read More

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http://link.springer.com/10.1007/s13311-019-00720-9
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http://dx.doi.org/10.1007/s13311-019-00720-9DOI Listing
February 2019
4 Reads

Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia.

Eur J Appl Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Sciences and Public Health, Sports Physiology Lab, University of Cagliari, Via Porcell 4, 09124, Cagliari, Italy.

Purpose: Little is known about the cardiovascular effects of the transition from exercise in hypoxia (EH) to normoxia. This investigation aimed to assess hemodynamics during the metaboreflex elicited in normoxia after EH.

Methods: Ten trained athletes (four females and six males, age 35. Read More

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http://dx.doi.org/10.1007/s00421-019-04103-yDOI Listing
February 2019

Are we there yet with patent foramen ovale closure for secondary prevention in cryptogenic stroke? A systematic review and meta-analysis of randomized trials.

SAGE Open Med 2019 4;7:2050312119828261. Epub 2019 Feb 4.

Department of Cardiovascular Diseases, Mayo Clinic, Phoenix, AZ, USA.

Background: We performed a meta-analysis to evaluate the benefit of patent foramen ovale closure in stroke prevention.

Methods: We searched Medline/PubMed, EMBASE, Web of Science and Cochrane central database for randomized control trials assessing the incidence of recurrent stroke after patent foramen ovale closure when compared to medical therapy. Pooled odds ratio and 95% confidence intervals were calculated using a random effects model. Read More

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http://dx.doi.org/10.1177/2050312119828261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365999PMC
February 2019

Cerebrovascular Disease in the Young Adult: Examining Melatonin's Possible Multiple Roles.

J Exp Neurosci 2019 5;13:1179069519827300. Epub 2019 Feb 5.

School of Medicine Greenville, University of South Carolina, Greenville, SC, USA.

In the last decade or more, there have been reports suggesting a rise in the incidence of stroke in young adults. Presently, it appears that the risk factors associated with the cause of stroke in young adults remain relatively constant across different geographic regions of the world. Moreover, the endogenous rhythm of a neurohormone such as melatonin is known to play certain roles in the modulation of some of the risk factors that are associated with an increased risk of stroke in young people. Read More

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http://dx.doi.org/10.1177/1179069519827300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366002PMC
February 2019

Delayed treatment of α5 GABAA receptor inverse agonist improves functional recovery by enhancing neurogenesis after cerebral ischemia-reperfusion injury in rat MCAO model.

Sci Rep 2019 Feb 19;9(1):2287. Epub 2019 Feb 19.

Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.

Development of effective therapeutics and treatment strategy to promote recovery after cerebral ischemia-reperfusion injury necessitates further understandings of the complex pathophysiology of ischemic stroke. Given that α5-GABAR inhibition has been shown to be involved in functional recovery after stroke, the present study was designed to evaluate the effects of treatment timing of α5 GABAR inhibition on post-middle cerebral artery occlusion (MCAO) functional recovery. To this end, we examined the effects of L655,708 (α5 GABAR inverse agonist) treatment at 3 or 7 days post-ischemia on apoptosis and neurogenesis in the peri-infarct region, brain infarction size, as well as modified neurological severity score (mNSS) and rotarod test time in rats. Read More

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http://dx.doi.org/10.1038/s41598-019-38750-0DOI Listing
February 2019

Renal Impairment Is Associated with Intracerebral Hemorrhage after Mechanical Thrombectomy in Vertebrobasilar Stroke.

Cerebrovasc Dis 2019 Feb 15;47(1-2):48-56. Epub 2019 Feb 15.

Department of Neurology, Heidelberg University Hospital, Heidelberg,

Background And Purpose: Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far.

Materials And Methods: Consecutive patients with vertebrobasilar stroke treated with mechanical thrombectomy between October 2010 and July 2017 at our center were analyzed. Read More

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http://dx.doi.org/10.1159/000497070DOI Listing
February 2019

Associations between statins and coronary artery disease and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome: A time-dependent regression study.

Atherosclerosis 2019 Feb 11;283:61-68. Epub 2019 Feb 11.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

Backgound And Aims: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).

Methods: We retrospectively enrolled patients with ACOS treated with (N = 916) and without (N = 6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.007DOI Listing
February 2019

Ischemic stroke and disseminated tuberculosis in a child living with human immunodeficiency virus: a case report and review of the literature.

J Med Case Rep 2019 Feb 20;13(1):38. Epub 2019 Feb 20.

Department of Pediatrics and Child Health, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia.

Background: Cerebrovascular accidents are rare in children. Rates of stroke in children with human immunodeficiency virus infection are higher than in the uninfected population.

Case Presentation: We report the case of a 19-month-old Ethiopian boy who presented with a left-sided body weakness of sudden onset. Read More

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http://dx.doi.org/10.1186/s13256-019-1990-2DOI Listing
February 2019

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice.

J Nanobiotechnology 2019 Feb 19;17(1):29. Epub 2019 Feb 19.

The Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.

Background: Accumulating evidence shows that microRNA-210 (miR-210) holds great promise to improve angiogenesis for brain tissue repair after cerebral ischemia. However, safe and efficient delivery of miR-210 via intravenous administration is still a challenge. In the past decade, exosomes have emerged as a novel endogenous delivery system. Read More

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http://dx.doi.org/10.1186/s12951-019-0461-7DOI Listing
February 2019

Tooth Loss Predicts Myocardial Infarction, Heart Failure, Stroke, and Death.

J Dent Res 2019 Feb;98(2):164-170

1 Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

We investigated whether oral health, represented by missing teeth, was associated with an increased risk of cardiovascular disease, including myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality. Subjects who underwent routine dental examinations and health checkups provided by the Korean National Health Insurance from 2007 to 2008 ( n = 4,440,970) were followed up for incident MI, HF, stroke, and death until 2016. During follow-up of 7. Read More

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http://dx.doi.org/10.1177/0022034518814829DOI Listing
February 2019

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.

Circ Res 2019 Feb 20. Epub 2019 Feb 20.

Center for Systems Biology, Massachusetts General Hospital.

Rationale: After stroke, patients frequently experience altered systemic immunity resulting in peripheral immunosuppression and higher susceptibility to infections, which is at least partly attributed to lymphopenia. The mechanisms that profoundly change the systemic leukocyte repertoire after stroke are incompletely understood. Emerging evidence indicates that stroke alters hematopoietic output of the bone marrow. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314518DOI Listing
February 2019

Cortical atrophy and transcallosal diaschisis following isolated subcortical stroke.

J Cereb Blood Flow Metab 2019 Feb 20:271678X19831583. Epub 2019 Feb 20.

1 Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Following acute ischemic stroke, isolated subcortical lesions induce gray matter atrophy in anatomically connected, yet distant cortical brain regions. We expand on previous studies by analyzing cortical thinning in contralesional, homologous regions indirectly linked to primary stroke lesions via ipsilesional cortical areas. For this purpose, stroke patients were serially studied by magnetic resonance imaging (diffusion tensor imaging and high-resolution anatomical imaging) in the acute (days 3-5) and late chronic stage one year after stroke. Read More

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http://dx.doi.org/10.1177/0271678X19831583DOI Listing
February 2019

Rate of strokes 1 year after retinal artery occlusion with analysis of risk groups.

Eur J Ophthalmol 2019 Feb 19:1120672119830925. Epub 2019 Feb 19.

VIROS-Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.

Background:: The risk of developing stroke after retinal artery occlusion was reported to be increased. The aim of our study was to assess the rate of strokes/transitory ischemic attacks after retinal artery occlusion in a European population and to identify the risk groups.

Methods:: All patients, diagnosed with branch or central retinal artery occlusion at our outpatient department since 2014, were asked to participate in this prospective case-control study. Read More

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http://dx.doi.org/10.1177/1120672119830925DOI Listing
February 2019

Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran.

Medicina (Kaunas) 2019 Feb 13;55(2). Epub 2019 Feb 13.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.

Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of as well as genes on ischemic stroke. In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for C677T, , and , , and prothrombin polymorphisms. Read More

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http://dx.doi.org/10.3390/medicina55020047DOI Listing
February 2019

Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity.

Medicina (Kaunas) 2019 Feb 15;55(2). Epub 2019 Feb 15.

Department of Cardiology, Kosuyolu Heart Education and Research Hospital, University of Health Sciences, 34844 Istanbul, Turkey.

In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention. We enrolled 180 patients with MVI-I, and 425 patients with MVI-S. Read More

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http://dx.doi.org/10.3390/medicina55020051DOI Listing
February 2019

Low-dose versus standard-dose intravenous alteplase for octogenerian acute ischemic stroke patients: A multicenter prospective cohort study.

J Neurol Sci 2019 Jan 29;399:76-81. Epub 2019 Jan 29.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background And Purpose: The optimal dose of alteplase for acute ischemic stroke among geriatric patients is unclear. We aimed to assess the efficacy and safety of a low-dose (0.6 mg/kg) and standard-dose (0. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.047DOI Listing
January 2019

A new, vasoactive hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety.

Eur J Pharm Sci 2019 Feb 16. Epub 2019 Feb 16.

Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary. Electronic address:

Ischemic heart conditions are among the main causes of sudden cardiac death worldwide. One of the strategies for avoiding myocardial infarction is the low-dose, prophylactic use of acetylsalicylic acid (ASA), an inhibitor of platelet aggregation. To avoid the gastrointestinal damage, ASA prodrugs bearing nitric oxide (NO)-donating moiety covalently conjugated to ASA have been synthesized and evaluated extensively worldwide. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.02.020DOI Listing
February 2019

tiRNAs as a Novel Biomarker for Cell Damage Assessment in In Vitro Ischemia-Reperfusion Model in Rat Neuronal PC12 Cells.

Brain Res 2019 Feb 16. Epub 2019 Feb 16.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

The disruption of appropriate cellular stress responses is implicated in the pathogenesis of different neurological disorders including ischemic injury. Early diagnosis and treatment are often associated with better prognosis in ischemic stroke patients. Thus, there is an urgent need to improve the speed and accuracy of stroke diagnosis by developing highly sensitive stroke biomarkers. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.019DOI Listing
February 2019

miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke.

Brain Res 2019 Feb 16. Epub 2019 Feb 16.

New Drug Innovation and Development Institute, Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei Province, China; Department of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, USA; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, Hubei Province, China. Electronic address:

Brain stroke is one of the leading causes of death worldwide. We explored a potential stroke-related role for a newly found microRNA, miR-1247-3p, and one of its target genes, caspase-2, predicted by TargetScanVert. In the present study, we found that miR-1247-3p was downregulated during ischemia/reperfusion (I/R) and that LV-miR-1247-3p overexpression attenuated brain impairment induced by I/R. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.020DOI Listing
February 2019

Mobility of an in-stent plaque protrusion detected with carotid duplex during the carotid artery stenting procedure: a case report.

Med Ultrason 2019 Feb;21(1):89-92

Department of Neurosurgery and Stroke Center, Tenri Hospital, Tenri, Japan.

In-stent plaque protrusion (ISP) is a predictor for ischemic complications in carotid artery stenting (CAS). Because its mobility would further increase the distal embolization risk, the intraprocedural detection of mobility is important but has not yet been reported. We present an 87-year-old male with symptomatic right carotid artery stenosis who underwent CAS. Read More

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http://dx.doi.org/10.11152/mu-1539DOI Listing
February 2019

Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia.

Cell Mol Neurobiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Various studies demonstrate that CD137 (TNFRSF9, 4-1BB) promotes atherosclerosis and vascular inflammation in experimental models via interactions with the CD137 ligand (CD137L). However, the exact role of CD137 in ischemic stroke remains unclear. In this study, we analyzed dynamic changes of peripheral CD137 expression on T cells in a mouse model of cerebral ischemia-middle cerebral artery occlusion (MCAO), as well as alternation of neurological function, infarct size and cerebral inflammatory status after inhibition of the CD137/CD137L pathway using an anti-CD137L monoclonal antibody. Read More

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http://dx.doi.org/10.1007/s10571-019-00661-zDOI Listing
February 2019

Factors related to improvement of cerebrovascular reserve after superficial temporal artery to middle cerebral artery anastomosis for patients with atherosclerotic steno-occlusive disease.

Acta Neurochir (Wien) 2019 Feb 18. Epub 2019 Feb 18.

Department of Cerebrovascular Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.

Background: This study aimed to investigate factors related to improvement of hemodynamics and evaluated the usefulness of intraoperative Doppler for predicting postoperative hemodynamics in patients with cerebrovascular atherosclerotic steno-occlusive disease (CASD) of the internal carotid artery (ICA) or middle cerebral artery (MCA) who were treated with extracranial-intracranial (EC-IC) bypass surgery.

Method: Forty-eight patients with CASD of the ICA or MCA who were treated by superficial temporal artery to middle cerebral artery bypass with a follow-up longer than 12 months were enrolled. Repeated transient ischemic attack or completed ischemic stroke was observed under optimal medical therapy in all patients. Read More

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http://dx.doi.org/10.1007/s00701-019-03841-4DOI Listing
February 2019

Risk factors of intracranial hemorrhage after mechanical thrombectomy of anterior circulation ischemic stroke.

Neuroradiology 2019 Feb 18. Epub 2019 Feb 18.

Department of Neuroradiology, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Intracranial hemorrhage (ICH) is a potentially severe complication after mechanical thrombectomy (MT). Here, we investigated risk factors for the occurrence of any and symptomatic ICH after MT due to large-vessel occlusion of the anterior circulation.

Methods: Consecutive patients with acute ischemic anterior circulation stroke with large-vessel occlusion undergoing MT were analyzed. Read More

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http://dx.doi.org/10.1007/s00234-019-02180-6DOI Listing
February 2019

Long Noncoding RNA-H19 Contributes to Atherosclerosis and Induces Ischemic Stroke via the Upregulation of Acid Phosphatase 5.

Front Neurol 2019 4;10:32. Epub 2019 Feb 4.

Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.

Atherosclerosis is closely associated with ischemic stroke, and long noncoding RNA-H19 (lncRNA-H19) might be a potential target for treating atherosclerosis. The present study aimed to investigate the function of lncRNA-H19 in atherosclerosis and to explore a novel therapeutic strategy for ischemic stroke. Differentially expressed genes (DEGs) in atherosclerosis were screened by searching public database. Read More

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http://dx.doi.org/10.3389/fneur.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369351PMC
February 2019

Tumour Necrosis Factor-α Inhibition Improves Stroke Outcome in a Mouse Model of Rheumatoid Arthritis.

Sci Rep 2019 Feb 18;9(1):2173. Epub 2019 Feb 18.

Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.

Rheumatoid Arthritis (RA) is a chronic inflammatory disorder where incidence and severity of myocardial infarction are increased. Data on the incidence and outcome of stroke are conflicting. Thus, we investigated outcome after Ischemia/Reperfusion (I/R) brain injury in a mouse model of RA and assessed for the role of the tumour necrosis factor-α (TNF-α) inhibitor Infliximab herein. Read More

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http://dx.doi.org/10.1038/s41598-019-38670-zDOI Listing
February 2019

[Effectiveness of correction of post-stroke motor disorders using the methods of functional electrostimulation and BFB-stabilometric postural control].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):23-30

Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department, Moscow, Russia.

Aim: To evaluate the effectiveness of complex rehabilitation with the inclusion of functional electrostimulation (FES) and BFB-stabilometric postural control in patients with post-stroke motor disorders in the late recovery period.

Material And Methods: Sixty-seven patients in the late recovery period of stroke, 31 women and 36 men, mean age 58.4±6. Read More

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http://dx.doi.org/10.17116/jnevro201911901123DOI Listing
January 2019

Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry.

J Neurointerv Surg 2019 Feb 18. Epub 2019 Feb 18.

Radiology & Nuclear Medicine, Amsterdam University Medical Center (AMC), Amsterdam, The Netherlands.

Background: Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent.

Methods: We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN) Registry (March 2014-June 2016) with an anterior circulation large vessel occlusion undergoing EVT. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014619DOI Listing
February 2019

Hypoperfusion in lenticulostriate arteries territory related to unexplained early neurological deterioration after intravenous thrombolysis.

Int J Stroke 2019 Feb 19:1747493019830595. Epub 2019 Feb 19.

1 Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Background: Early neurological deterioration occurs in approximately 10% acute ischemic stroke patients after thrombolysis. Over half of the early neurological deterioration occurred without known causes and is called unexplained early neurological deterioration.

Aims: We aimed to explore the development of early neurological deterioration at 24 h after thrombolysis, and whether it could be predicted by the presence of baseline hypoperfusion in lenticulostriate arteries territory in acute ischemic stroke patients. Read More

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http://dx.doi.org/10.1177/1747493019830595DOI Listing
February 2019

Results of retrograde open mesenteric stenting for acute thrombotic mesenteric ischemia.

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Vascular and Thoracic Surgery, Bichat Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; SURVI (Structure d'URgences Vasculaires Intestinales)-Intestinal Stroke Center, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine Denis Diderot-Paris 7, Paris, France.

Objective: Acute mesenteric ischemia (AMI) is an emergent event with a high mortality rate; survivors have high rates of intestinal failure. Restoration of blood flow using endovascular or surgical revascularization is associated with better outcome in terms of survival rate and intestinal resection. Retrograde open mesenteric stenting (ROMS), which is a hybrid technique, combines two benefits: prompt blood flow restoration with an endovascular approach and inspection and resection of the small bowel. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.07.058DOI Listing
February 2019

Predictors of in-hospital adverse events after endovascular aortic aneurysm repair.

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Vascular and Endovascular Research Center, Johns Hopkins University, Baltimore, Md. Electronic address:

Background: Endovascular aneurysm repair (EVAR) offered outstanding survival benefit but at the expense of cost, periodic radiographic monitoring, and higher reinterventions rates. Perioperative complications, although rare, can occur after EVAR, contributing to longer hospitalization, higher cost, and significant comorbidity and mortality. Therefore, the aim of this study was to identify the predictors of in-hospital events (IHEs) after elective EVAR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07415214183255
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http://dx.doi.org/10.1016/j.jvs.2018.10.093DOI Listing
February 2019
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Risk of emergent carotid endarterectomy varies by type of presenting symptoms.

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, Md. Electronic address:

Background: The timing of carotid revascularization in symptomatic patients is a matter of ongoing debate. Current evidence indicates that carotid endarterectomy (CEA) within 2 weeks of symptoms is superior to delayed treatment. However, there is little evidence on the outcomes of emergent CEA (eCEA). Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.064DOI Listing
February 2019

Intra-Arterial Injection of Autologous Bone Marrow-Derived Mononuclear Cells in Ischemic Stroke Patients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):239-241

From the Alyermouk Teaching Hospital, Baghdad, Iraq; and the Packy Hospital, Erbil, Iraq.

Objectives: This study aimed to show the positive effects of autologous bone marrow-derived mononuclear cells in the functional recovery of adult patients with subacute and chronic ischemic stroke. Stroke is a leading cause of morbidity and long-term disability in the world, with about one-third of survivors being permanently disabled. Bone marrowderived mononuclear cell concentrate is thought to improve cerebral blood flow and to speed recovery in animal models. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P102DOI Listing
January 2019

Cardiovascular Outcomes of Patients With Pulmonary Hypertension Undergoing Noncardiac Surgery.

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY; Department of Surgery, New York University School of Medicine, New York, NY.

Pulmonary hypertension (PH), defined by a mean pulmonary artery pressure of >25mm Hg at rest, is strongly associated with morbidity and mortality in the perioperative period. The prevalence and outcomes of PH among patients referred for major noncardiac surgery in the United States are unknown. Patients ≥18 years of age hospitalized for noncardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data from 2004 to 2014. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.006DOI Listing
February 2019

Mechanical thrombectomy and the future of acute stroke treatment.

Eur J Radiol 2019 Mar 29;112:214-221. Epub 2019 Jan 29.

Departments of Medical Imaging & Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

After being staggered by numerous negative trials in 2013, the interventional stroke community saw four years of vindication for mechanical thrombectomy showing efficacy and safety, even beyond a hopeful 6-8 hour window out to 24 h. A landmark set of five trials in 2015 provided a foundation upon which years of incremental follow-ups, meta-analyses and new breakthroughs would be built. With optimized devices for thrombectomy and image analysis, the neurointerventional community has turned to workflow and systemization in this new era of acute ischemic stroke treatment. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.029DOI Listing

Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke.

Acta Neuropathol Commun 2019 Feb 18;7(1):23. Epub 2019 Feb 18.

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 240 W Green Street, Athens, GA, 30602, USA.

At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibits inflammatory cell extravasation in pathological conditions. Whether mural cell-derived laminin-α5 is involved in vascular integrity regulation, however, remains unknown. Read More

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http://dx.doi.org/10.1186/s40478-019-0676-8DOI Listing
February 2019

CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke.

J Neuroinflammation 2019 Feb 18;16(1):40. Epub 2019 Feb 18.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77370, USA.

Background: Ischemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor 1 (CD200R1) signaling axis is a known regulator of immune homeostasis, we hypothesized that it may play a role in post-stroke immune suppression after stroke.

Methods: In this study, we investigated the role of CD200R1-mediated signaling in stroke using CD200 receptor 1-deficient mice. Read More

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http://dx.doi.org/10.1186/s12974-019-1426-3DOI Listing
February 2019
5.408 Impact Factor

Glucose Modifies the Effect of Endovascular Thrombectomy in Patients With Acute Stroke.

Stroke 2019 Feb 19:STROKEAHA118023769. Epub 2019 Feb 19.

Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada (A.M.D., M.A., M. Goyal, B.K.M.).

Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment modifier of the efficacy of EVT in acute stroke. Methods- Seven randomized trials compared EVT with standard care between 2010 and 2017 (HERMES Collaboration [highly effective reperfusion using multiple endovascular devices]). Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023769DOI Listing
February 2019

Time to Loading Dose and Risk of Recurrent Events in the SOCRATES Trial.

Stroke 2019 Feb 19:STROKEAHA118022675. Epub 2019 Feb 19.

Department of Medicine & Therapeutics, The Chinese University of Hong Kong (K.S.L.W.).

Background and Purpose- Recurrent ischemia risk is high in the acute period after cerebral ischemic events. Effects of antiplatelet agents may vary by time to loading dose (TLD). We explored the risk of recurrent events and safety and efficacy of ticagrelor versus aspirin in relation to TLD. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022675DOI Listing
February 2019