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PLoS One 2019 20;14(2):e0212519. Epub 2019 Feb 20.

Semmelweis University, Department of Neurology, Budapest, Hungary.

Introduction: Hungary has a single payer health insurance system offering free healthcare for acute cerebrovascular disorders. Within the capital, Budapest, however there are considerable microregional socioeconomic differences. We hypothesized that socioeconomic deprivation reflects in less favorable stroke characteristics despite universal access to care. Read More

Circ Cardiovasc Qual Outcomes 2018 Nov 14;11(11):13. Epub 2018 Nov 14.

Background: The CTSN (Cardiothoracic Surgical Trials Network) recently reported no difference in left ventricular end-systolic volume index or in survival at 2 years between patients with severe ischemic mitral regurgitation (MR) randomized to mitral valve repair or replacement. However, replacement provided more durable correction of MR and fewer cardiovascular readmissions. Yet, costeffectiveness outcomes have not been addressed. Read More

Ideggyogy Sz 2019 Jan;72(1-2):65-70

Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ, Neurológiai Klinika, Szeged.

Hereditary hemorrhagic teleangiectasia (HHT, Osler-Rendu-Weber disease) is an autosomal dominantly inherited disorder caused by the mutation of several possible genes and characterized by malformations of the arteriovenous system in multiple organs. The clinical diagnosis is based on the Curaçao criteria ((1) spontaneous, recurrent epistaxis; (2) teleangiectasias in characteristic sites (lips, oral cavity, nose, fingers); (3) visceral lesions (gastrointestinal, pulmonary, cerebral, spinal); (4) affected first degree relative). The aim of this study is to present the first genetically confirmed Hungarian case of hereditary hemorrhagic teleangiectasia with multiple ischemic strokes. Read More

Adv Healthc Mater 2019 Feb 20:e1801294. Epub 2019 Feb 20.

Robarts Research Institute, Department of Medicine (Cardiology), Department of Biochemistry, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London Health Sciences Centre, 339 Windermere Rd, London, Ontario, N6A 5A5, Canada.

Delivery of angiogenic growth factors lessens ischemia in preclinical models but has demonstrated little benefit in patients with peripheral vascular disease. Augmenting the wrapping of nascent microvessels by mural cells constitutes an alternative strategy to regenerating a functional microvasculature, particularly if integrated with a sustained delivery platform. Herein, electrospun poly(ester amide) (PEA) nanofiber mats are fabricated for delivering a mural cell-targeting factor, fibroblast growth factor 9 (FGF9). Read More

J Card Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Cardiovascular Surgery, Health Sciences University Gülhane Training and Research Hospital, Ankara, Turkey.

Left ventriculotomy for thrombus removal is usually associated with a high incidence of cardiac arrhythmias and decreased ejection fraction. A 51-year-old male patient was admitted to the emergency department with loss of consciousness. Transthoracic echocardiography revealed a 20 × 24-mm left ventricular apical nonpedunculated thrombus with normal ejection fraction. Read More

Ann Neurol 2019 Feb 19. Epub 2019 Feb 19.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Objective: Trials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiologic studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS). We assessed whether circulating tHcy and B vitamin levels are selectively associated with SVS, but not other stroke subtypes, using Mendelian randomization. Read More

Environ Int 2019 Feb 20;126:89-95. Epub 2019 Feb 20.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Institut national de santé publique du Québec, Montreal, Quebec, Canada; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada. Electronic address:

Background: We sought to determine if cold temperature and snowfall are independently associated with stroke mortality, and whether effects differ between hemorrhagic and ischemic stroke.

Materials And Methods: We conducted a case-crossover study of 13,201 stroke deaths utilizing weather records between the months of November and April for Quebec, Canada from 1981 to 2015. We compared exposure to cold temperature and snowfall with controls days when stroke death did not occur. Read More

JACC Clin Electrophysiol 2019 Feb 1;5(2):231-241. Epub 2018 Nov 1.

Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Department of Medicine, Stanford University School of Medicine, Stanford, California; Center for Digital Health, Stanford University School of Medicine, Stanford, California. Electronic address:

Objectives: In this study the authors investigated effectiveness and safety of an initial treatment strategy with class IC or class III antiarrhythmic drugs (AAD) for newly diagnosed atrial fibrillation (AF) or atrial flutter (AFL).

Background: There is limited evidence to guide optimal AAD selection for rhythm control in newly diagnosed AF/AFL.

Methods: Using data from TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF), the authors performed a retrospective cohort study of patients with AF/AFL from 2004 to 2014 and class IC or class III AAD prescription within 90 days following diagnosis. Read More

JACC Cardiovasc Interv 2019 Feb;12(4):395-403

Department of Angiology, Universitats Herzzentrum Freiburg-Bad Krozingen, Bad Krozingen, Germany.

Objectives: This study evaluated the safety and performance of the Paladin System, a novel angioplasty balloon with an integrated embolic protection filter designed to increase embolic protection during post-dilation.

Background: The risk of major adverse events during carotid artery stenting (CAS) is equivalent to carotid endarterectomy. However, the risk of minor stroke remains higher with CAS. Read More

JACC Cardiovasc Interv 2019 Feb;12(4):392-394

Ochsner Clinical School, Ochsner Medical Center, New Orleans, Louisiana. Electronic address:

JACC Cardiovasc Interv 2019 Feb;12(4):385-391

Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Versailles, France; Versailles Saint-Quentin en Yvelines and Paris Saclay University, Versailles, France; INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France. Electronic address:

Objectives: The aim of this study was to determine whether individual operator characteristics have an impact on reperfusion and procedural complication rates.

Background: Mechanical thrombectomy (MT) is a Level IA treatment in acute ischemic stroke (AIS) patients. The operator's effect has been found to be an independent predictor for clinical outcome and technical performance in interventional cardiology. Read More

CNS Neurosci Ther 2019 Feb 19. Epub 2019 Feb 19.

Shanghai Jiao Tong Affiliated Sixth People's Hospital, Neuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Introduction: Dl-3-N-butylphthalide (NBP), a small molecule drug used clinically in the acute phase of ischemic stroke, has been shown to improve functional recovery and promote angiogenesis and collateral vessel circulation after experimental cerebral ischemia. However, the underlying molecular mechanism is unknown.

Aims: To explore the potential molecular mechanism of angiogenesis induced by NBP after cerebral ischemia. Read More

Neurotherapeutics 2019 Feb 19. Epub 2019 Feb 19.

Valtari Bio Incorporated, Morgantown, West Virginia, USA.

Accurate stroke recognition during triage can streamline care and afford patients earlier access to life-saving interventions. However, the tools currently available to clinicians for prehospital and early in-hospital identification of stroke are limited. The peripheral immune system is intricately involved in stroke pathology and thus may be targetable for the development of immunodiagnostics. Read More

Eur J Appl Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Sciences and Public Health, Sports Physiology Lab, University of Cagliari, Via Porcell 4, 09124, Cagliari, Italy.

Purpose: Little is known about the cardiovascular effects of the transition from exercise in hypoxia (EH) to normoxia. This investigation aimed to assess hemodynamics during the metaboreflex elicited in normoxia after EH.

Methods: Ten trained athletes (four females and six males, age 35. Read More

SAGE Open Med 2019 4;7:2050312119828261. Epub 2019 Feb 4.

Department of Cardiovascular Diseases, Mayo Clinic, Phoenix, AZ, USA.

Background: We performed a meta-analysis to evaluate the benefit of patent foramen ovale closure in stroke prevention.

Methods: We searched Medline/PubMed, EMBASE, Web of Science and Cochrane central database for randomized control trials assessing the incidence of recurrent stroke after patent foramen ovale closure when compared to medical therapy. Pooled odds ratio and 95% confidence intervals were calculated using a random effects model. Read More

J Exp Neurosci 2019 5;13:1179069519827300. Epub 2019 Feb 5.

School of Medicine Greenville, University of South Carolina, Greenville, SC, USA.

In the last decade or more, there have been reports suggesting a rise in the incidence of stroke in young adults. Presently, it appears that the risk factors associated with the cause of stroke in young adults remain relatively constant across different geographic regions of the world. Moreover, the endogenous rhythm of a neurohormone such as melatonin is known to play certain roles in the modulation of some of the risk factors that are associated with an increased risk of stroke in young people. Read More

Sci Rep 2019 Feb 19;9(1):2287. Epub 2019 Feb 19.

Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.

Development of effective therapeutics and treatment strategy to promote recovery after cerebral ischemia-reperfusion injury necessitates further understandings of the complex pathophysiology of ischemic stroke. Given that α5-GABAR inhibition has been shown to be involved in functional recovery after stroke, the present study was designed to evaluate the effects of treatment timing of α5 GABAR inhibition on post-middle cerebral artery occlusion (MCAO) functional recovery. To this end, we examined the effects of L655,708 (α5 GABAR inverse agonist) treatment at 3 or 7 days post-ischemia on apoptosis and neurogenesis in the peri-infarct region, brain infarction size, as well as modified neurological severity score (mNSS) and rotarod test time in rats. Read More

Cerebrovasc Dis 2019 Feb 15;47(1-2):48-56. Epub 2019 Feb 15.

Department of Neurology, Heidelberg University Hospital, Heidelberg,

Background And Purpose: Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far.

Materials And Methods: Consecutive patients with vertebrobasilar stroke treated with mechanical thrombectomy between October 2010 and July 2017 at our center were analyzed. Read More

Atherosclerosis 2019 Feb 11;283:61-68. Epub 2019 Feb 11.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

Backgound And Aims: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).

Methods: We retrospectively enrolled patients with ACOS treated with (N = 916) and without (N = 6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. Read More

J Med Case Rep 2019 Feb 20;13(1):38. Epub 2019 Feb 20.

Department of Pediatrics and Child Health, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia.

Background: Cerebrovascular accidents are rare in children. Rates of stroke in children with human immunodeficiency virus infection are higher than in the uninfected population.

Case Presentation: We report the case of a 19-month-old Ethiopian boy who presented with a left-sided body weakness of sudden onset. Read More

J Nanobiotechnology 2019 Feb 19;17(1):29. Epub 2019 Feb 19.

The Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.

Background: Accumulating evidence shows that microRNA-210 (miR-210) holds great promise to improve angiogenesis for brain tissue repair after cerebral ischemia. However, safe and efficient delivery of miR-210 via intravenous administration is still a challenge. In the past decade, exosomes have emerged as a novel endogenous delivery system. Read More

J Dent Res 2019 Feb;98(2):164-170

1 Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

We investigated whether oral health, represented by missing teeth, was associated with an increased risk of cardiovascular disease, including myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality. Subjects who underwent routine dental examinations and health checkups provided by the Korean National Health Insurance from 2007 to 2008 ( n = 4,440,970) were followed up for incident MI, HF, stroke, and death until 2016. During follow-up of 7. Read More

Circ Res 2019 Feb 20. Epub 2019 Feb 20.

Center for Systems Biology, Massachusetts General Hospital.

Rationale: After stroke, patients frequently experience altered systemic immunity resulting in peripheral immunosuppression and higher susceptibility to infections, which is at least partly attributed to lymphopenia. The mechanisms that profoundly change the systemic leukocyte repertoire after stroke are incompletely understood. Emerging evidence indicates that stroke alters hematopoietic output of the bone marrow. Read More

J Cereb Blood Flow Metab 2019 Feb 20:271678X19831583. Epub 2019 Feb 20.

1 Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Following acute ischemic stroke, isolated subcortical lesions induce gray matter atrophy in anatomically connected, yet distant cortical brain regions. We expand on previous studies by analyzing cortical thinning in contralesional, homologous regions indirectly linked to primary stroke lesions via ipsilesional cortical areas. For this purpose, stroke patients were serially studied by magnetic resonance imaging (diffusion tensor imaging and high-resolution anatomical imaging) in the acute (days 3-5) and late chronic stage one year after stroke. Read More

Eur J Ophthalmol 2019 Feb 19:1120672119830925. Epub 2019 Feb 19.

VIROS-Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.

Background:: The risk of developing stroke after retinal artery occlusion was reported to be increased. The aim of our study was to assess the rate of strokes/transitory ischemic attacks after retinal artery occlusion in a European population and to identify the risk groups.

Methods:: All patients, diagnosed with branch or central retinal artery occlusion at our outpatient department since 2014, were asked to participate in this prospective case-control study. Read More

Medicina (Kaunas) 2019 Feb 13;55(2). Epub 2019 Feb 13.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.

Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of as well as genes on ischemic stroke. In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for C677T, , and , , and prothrombin polymorphisms. Read More

Medicina (Kaunas) 2019 Feb 15;55(2). Epub 2019 Feb 15.

Department of Cardiology, Kosuyolu Heart Education and Research Hospital, University of Health Sciences, 34844 Istanbul, Turkey.

In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention. We enrolled 180 patients with MVI-I, and 425 patients with MVI-S. Read More

J Neurol Sci 2019 Jan 29;399:76-81. Epub 2019 Jan 29.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background And Purpose: The optimal dose of alteplase for acute ischemic stroke among geriatric patients is unclear. We aimed to assess the efficacy and safety of a low-dose (0.6 mg/kg) and standard-dose (0. Read More

Eur J Pharm Sci 2019 Feb 16. Epub 2019 Feb 16.

Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary. Electronic address:

Ischemic heart conditions are among the main causes of sudden cardiac death worldwide. One of the strategies for avoiding myocardial infarction is the low-dose, prophylactic use of acetylsalicylic acid (ASA), an inhibitor of platelet aggregation. To avoid the gastrointestinal damage, ASA prodrugs bearing nitric oxide (NO)-donating moiety covalently conjugated to ASA have been synthesized and evaluated extensively worldwide. Read More

Brain Res 2019 Feb 16. Epub 2019 Feb 16.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

The disruption of appropriate cellular stress responses is implicated in the pathogenesis of different neurological disorders including ischemic injury. Early diagnosis and treatment are often associated with better prognosis in ischemic stroke patients. Thus, there is an urgent need to improve the speed and accuracy of stroke diagnosis by developing highly sensitive stroke biomarkers. Read More

Brain Res 2019 Feb 16. Epub 2019 Feb 16.

New Drug Innovation and Development Institute, Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei Province, China; Department of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, USA; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, Hubei Province, China. Electronic address:

Brain stroke is one of the leading causes of death worldwide. We explored a potential stroke-related role for a newly found microRNA, miR-1247-3p, and one of its target genes, caspase-2, predicted by TargetScanVert. In the present study, we found that miR-1247-3p was downregulated during ischemia/reperfusion (I/R) and that LV-miR-1247-3p overexpression attenuated brain impairment induced by I/R. Read More

Med Ultrason 2019 Feb;21(1):89-92

Department of Neurosurgery and Stroke Center, Tenri Hospital, Tenri, Japan.

In-stent plaque protrusion (ISP) is a predictor for ischemic complications in carotid artery stenting (CAS). Because its mobility would further increase the distal embolization risk, the intraprocedural detection of mobility is important but has not yet been reported. We present an 87-year-old male with symptomatic right carotid artery stenosis who underwent CAS. Read More

Cell Mol Neurobiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Various studies demonstrate that CD137 (TNFRSF9, 4-1BB) promotes atherosclerosis and vascular inflammation in experimental models via interactions with the CD137 ligand (CD137L). However, the exact role of CD137 in ischemic stroke remains unclear. In this study, we analyzed dynamic changes of peripheral CD137 expression on T cells in a mouse model of cerebral ischemia-middle cerebral artery occlusion (MCAO), as well as alternation of neurological function, infarct size and cerebral inflammatory status after inhibition of the CD137/CD137L pathway using an anti-CD137L monoclonal antibody. Read More

Acta Neurochir (Wien) 2019 Feb 18. Epub 2019 Feb 18.

Department of Cerebrovascular Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.

Background: This study aimed to investigate factors related to improvement of hemodynamics and evaluated the usefulness of intraoperative Doppler for predicting postoperative hemodynamics in patients with cerebrovascular atherosclerotic steno-occlusive disease (CASD) of the internal carotid artery (ICA) or middle cerebral artery (MCA) who were treated with extracranial-intracranial (EC-IC) bypass surgery.

Method: Forty-eight patients with CASD of the ICA or MCA who were treated by superficial temporal artery to middle cerebral artery bypass with a follow-up longer than 12 months were enrolled. Repeated transient ischemic attack or completed ischemic stroke was observed under optimal medical therapy in all patients. Read More

Neuroradiology 2019 Feb 18. Epub 2019 Feb 18.

Department of Neuroradiology, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Intracranial hemorrhage (ICH) is a potentially severe complication after mechanical thrombectomy (MT). Here, we investigated risk factors for the occurrence of any and symptomatic ICH after MT due to large-vessel occlusion of the anterior circulation.

Methods: Consecutive patients with acute ischemic anterior circulation stroke with large-vessel occlusion undergoing MT were analyzed. Read More

Front Neurol 2019 4;10:32. Epub 2019 Feb 4.

Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.

Atherosclerosis is closely associated with ischemic stroke, and long noncoding RNA-H19 (lncRNA-H19) might be a potential target for treating atherosclerosis. The present study aimed to investigate the function of lncRNA-H19 in atherosclerosis and to explore a novel therapeutic strategy for ischemic stroke. Differentially expressed genes (DEGs) in atherosclerosis were screened by searching public database. Read More

Sci Rep 2019 Feb 18;9(1):2173. Epub 2019 Feb 18.

Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.

Rheumatoid Arthritis (RA) is a chronic inflammatory disorder where incidence and severity of myocardial infarction are increased. Data on the incidence and outcome of stroke are conflicting. Thus, we investigated outcome after Ischemia/Reperfusion (I/R) brain injury in a mouse model of RA and assessed for the role of the tumour necrosis factor-α (TNF-α) inhibitor Infliximab herein. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):23-30

Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department, Moscow, Russia.

Aim: To evaluate the effectiveness of complex rehabilitation with the inclusion of functional electrostimulation (FES) and BFB-stabilometric postural control in patients with post-stroke motor disorders in the late recovery period.

Material And Methods: Sixty-seven patients in the late recovery period of stroke, 31 women and 36 men, mean age 58.4±6. Read More

J Neurointerv Surg 2019 Feb 18. Epub 2019 Feb 18.

Radiology & Nuclear Medicine, Amsterdam University Medical Center (AMC), Amsterdam, The Netherlands.

Background: Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent.

Methods: We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN) Registry (March 2014-June 2016) with an anterior circulation large vessel occlusion undergoing EVT. Read More

Int J Stroke 2019 Feb 19:1747493019830595. Epub 2019 Feb 19.

1 Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Background: Early neurological deterioration occurs in approximately 10% acute ischemic stroke patients after thrombolysis. Over half of the early neurological deterioration occurred without known causes and is called unexplained early neurological deterioration.

Aims: We aimed to explore the development of early neurological deterioration at 24 h after thrombolysis, and whether it could be predicted by the presence of baseline hypoperfusion in lenticulostriate arteries territory in acute ischemic stroke patients. Read More

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Vascular and Thoracic Surgery, Bichat Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; SURVI (Structure d'URgences Vasculaires Intestinales)-Intestinal Stroke Center, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine Denis Diderot-Paris 7, Paris, France.

Objective: Acute mesenteric ischemia (AMI) is an emergent event with a high mortality rate; survivors have high rates of intestinal failure. Restoration of blood flow using endovascular or surgical revascularization is associated with better outcome in terms of survival rate and intestinal resection. Retrograde open mesenteric stenting (ROMS), which is a hybrid technique, combines two benefits: prompt blood flow restoration with an endovascular approach and inspection and resection of the small bowel. Read More

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Vascular and Endovascular Research Center, Johns Hopkins University, Baltimore, Md. Electronic address:

Background: Endovascular aneurysm repair (EVAR) offered outstanding survival benefit but at the expense of cost, periodic radiographic monitoring, and higher reinterventions rates. Perioperative complications, although rare, can occur after EVAR, contributing to longer hospitalization, higher cost, and significant comorbidity and mortality. Therefore, the aim of this study was to identify the predictors of in-hospital events (IHEs) after elective EVAR. Read More

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, Md. Electronic address:

Background: The timing of carotid revascularization in symptomatic patients is a matter of ongoing debate. Current evidence indicates that carotid endarterectomy (CEA) within 2 weeks of symptoms is superior to delayed treatment. However, there is little evidence on the outcomes of emergent CEA (eCEA). Read More

Exp Clin Transplant 2019 Jan;17(Suppl 1):239-241

From the Alyermouk Teaching Hospital, Baghdad, Iraq; and the Packy Hospital, Erbil, Iraq.

Objectives: This study aimed to show the positive effects of autologous bone marrow-derived mononuclear cells in the functional recovery of adult patients with subacute and chronic ischemic stroke. Stroke is a leading cause of morbidity and long-term disability in the world, with about one-third of survivors being permanently disabled. Bone marrowderived mononuclear cell concentrate is thought to improve cerebral blood flow and to speed recovery in animal models. Read More

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY; Department of Surgery, New York University School of Medicine, New York, NY.

Pulmonary hypertension (PH), defined by a mean pulmonary artery pressure of >25mm Hg at rest, is strongly associated with morbidity and mortality in the perioperative period. The prevalence and outcomes of PH among patients referred for major noncardiac surgery in the United States are unknown. Patients ≥18 years of age hospitalized for noncardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data from 2004 to 2014. Read More

Eur J Radiol 2019 Mar 29;112:214-221. Epub 2019 Jan 29.

Departments of Medical Imaging & Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

After being staggered by numerous negative trials in 2013, the interventional stroke community saw four years of vindication for mechanical thrombectomy showing efficacy and safety, even beyond a hopeful 6-8 hour window out to 24 h. A landmark set of five trials in 2015 provided a foundation upon which years of incremental follow-ups, meta-analyses and new breakthroughs would be built. With optimized devices for thrombectomy and image analysis, the neurointerventional community has turned to workflow and systemization in this new era of acute ischemic stroke treatment. Read More

Acta Neuropathol Commun 2019 Feb 18;7(1):23. Epub 2019 Feb 18.

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 240 W Green Street, Athens, GA, 30602, USA.

At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibits inflammatory cell extravasation in pathological conditions. Whether mural cell-derived laminin-α5 is involved in vascular integrity regulation, however, remains unknown. Read More

J Neuroinflammation 2019 Feb 18;16(1):40. Epub 2019 Feb 18.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77370, USA.

Background: Ischemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor 1 (CD200R1) signaling axis is a known regulator of immune homeostasis, we hypothesized that it may play a role in post-stroke immune suppression after stroke.

Methods: In this study, we investigated the role of CD200R1-mediated signaling in stroke using CD200 receptor 1-deficient mice. Read More

Stroke 2019 Feb 19:STROKEAHA118023769. Epub 2019 Feb 19.

Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada (A.M.D., M.A., M. Goyal, B.K.M.).

Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment modifier of the efficacy of EVT in acute stroke. Methods- Seven randomized trials compared EVT with standard care between 2010 and 2017 (HERMES Collaboration [highly effective reperfusion using multiple endovascular devices]). Read More

Stroke 2019 Feb 19:STROKEAHA118022675. Epub 2019 Feb 19.

Department of Medicine & Therapeutics, The Chinese University of Hong Kong (K.S.L.W.).

Background and Purpose- Recurrent ischemia risk is high in the acute period after cerebral ischemic events. Effects of antiplatelet agents may vary by time to loading dose (TLD). We explored the risk of recurrent events and safety and efficacy of ticagrelor versus aspirin in relation to TLD. Read More