84,522 results match your criteria Stroke Ischemic


Age at menarche and risk of all-cause and cardiovascular mortality: a systematic review and dose-response meta-analysis.

Menopause 2018 Dec 17. Epub 2018 Dec 17.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Objective: The evidence between age at menarche and mortality risk is controversial. We aimed to quantify the dose-response association of age at menarche and risk of all-cause and cardiovascular disease (CVD) mortality based on cohort studies.

Methods: PubMed, EMBASE, Web of Science, and Scopus databases were searched up to March 15, 2018 for relevant articles. Read More

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http://dx.doi.org/10.1097/GME.0000000000001289DOI Listing
December 2018

Futile Recanalization With Poor Clinical Outcome Is Associated With Increased Edema Volume After Ischemic Stroke.

Invest Radiol 2018 Dec 17. Epub 2018 Dec 17.

From the Department of Diagnostic and Interventional Neuroradiology, and.

Purpose: Futile recanalization with poor clinical outcome after endovascular treatment of acute ischemic stroke is poorly understood. Recently, vessel recanalization has been associated with reduced ischemic brain edema in patients with good clinical outcome. As edema volume (EV) may be quantified in computed tomography (CT), we hypothesized that higher EV after revascularization predicts futile recanalization with poor outcome. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000539DOI Listing
December 2018

Association between non-high-density lipoprotein cholesterol levels and the prevalence of asymptomatic extracranial internal carotid artery stenosis in a Chinese community-based study.

Eur J Neurol 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurology, Beijing Tiantan Hospital, Capital medical University, Beijing, China.

Background And Purpose: Extracranial internal carotid artery (EICA) thromboembolism is one major cause of ischemic stroke and the predictive value of non-high-density lipoprotein cholesterol (non-HDLC) is superior to low-density lipoprotein cholesterol (LDL-C). This study aims to assess the association between non-HDLC levels and the prevalence of asymptomatic EICA stenosis (EICAS) as well as the predictive value of non-HDLC over LDL-C on EICAS presence.

Methods: The Asymptomatic Polyvascular Abnormalities Community (APAC) study is a subset of Kailuan Study emphasizing on asymptomatic polyvascular abnormalities in Chinese adults. Read More

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http://dx.doi.org/10.1111/ene.13882DOI Listing
December 2018

Association Between Carotid Artery Perivascular Fat Density and Cerebrovascular Ischemic Events.

J Am Heart Assoc 2018 Dec;7(24):e010383

2 Department of Radiology Weill Cornell Medicine New York NY.

Background Studies have shown that pericoronary artery inflammation can be accurately detected via increased attenuation on computed tomography. Our purpose was to evaluate the association between pericarotid inflammation, measured by density of carotid perivascular fat on computed tomography angiography, with stroke and transient ischemic attack. Methods and Results We screened computed tomography angiography examinations for patients with unilateral internal carotid artery ( ICA ) stenosis ≥50% to 99%. Read More

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http://dx.doi.org/10.1161/JAHA.118.010383DOI Listing
December 2018

Trevo 2000: Results of a Large Real-World Registry for Stent Retriever for Acute Ischemic Stroke.

J Am Heart Assoc 2018 Dec;7(24):e010867

1 Department of Neurosciences Drexel Neurosciences Institute Philadelphia PA.

Background Recent randomized controlled trials show benefit of thrombectomy for large vessel occlusion in stroke. Real-world data aid in assessing reproducibility of outcomes outside of clinical trials. The Trevo Retriever Registry is a multicenter, international, prospective study designed to assess outcomes in a large cohort of patients. Read More

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http://dx.doi.org/10.1161/JAHA.118.010867DOI Listing
December 2018

Relationship of Inter-Individual Blood Pressure Variability and the Risk for Recurrent Stroke.

J Am Heart Assoc 2018 Dec;7(24):e009480

3 Pfizer Essential Health Pfizer New York NY.

Background Evidence suggests that patients with higher blood pressure variability ( BPV ) have a higher risk for stroke, but any link between BPV and stroke recurrence is unknown among those who had a stroke or transient ischemic attack ( TIA ). Methods and Results Data for patients with a history of stroke or TIA at enrollment were extracted from the ASCOT (Anglo Scandinavian Cardiac Outcomes Trial) and the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). BPV was defined as the within-subject standard deviation or coefficient of variation of systolic blood pressure across visits from 12 weeks poststroke or TIA onward. Read More

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http://dx.doi.org/10.1161/JAHA.118.009480DOI Listing
December 2018

[Non-cardioembolic ischemic stroke hypertensive patients, a therapeutic hope. Reply].

Rev Neurol 2019 Jan;68(1):44-45

Centro Nacional de Investigaciones Cientificas (CNIC), Playa, La Habana, Cuba.

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January 2019

[Non-cardioembolic ischemic stroke hypertensive patients, a therapeutic hope].

Rev Neurol 2019 Jan;68(1):44

Universidad de Ciencias Medicas de La Habana, La Habana, Cuba.

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January 2019

Moyamoya angiopathy: long-term follow-up study in a Finnish population.

J Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology and Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background And Purpose: Moyamoya angiopathy (MMA) is a chronic cerebrovascular disorder predominantly starting in childhood or early adulthood and thus affects the whole lifetime. Little is known on MMAs long-term outcomes in European patients. We report long-term follow-up data on Finnish MMA patients. Read More

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http://dx.doi.org/10.1007/s00415-018-9154-7DOI Listing
December 2018

Resection of left atrial appendage aneurysm and full maze procedure as curative management for stroke recurrence.

Gen Thorac Cardiovasc Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Thoracic and Cardiovascular Surgery, Hirosaki University School of Medicine, 5 Zaifucyo, Hirosaki, Aomori, Japan.

Left atrial appendage aneurysm (LAAA) is a rare congenital heart anomaly that frequently becomes apparent after middle age. We report a case of LAAA in a 63-year-old woman with stroke. After stabilization of ischemic cerebral stroke, the patient underwent left atrial appendectomy with full maze procedure and tricuspid annuloplasty under cardiac arrest with cardiopulmonary bypasss. Read More

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http://dx.doi.org/10.1007/s11748-018-1048-1DOI Listing
December 2018

Association between Increased Matrix Metalloproteinase-9 (MMP-9) Levels with Hyperglycaemia Incidence in Acute Ischemic Stroke Patients.

Open Access Maced J Med Sci 2018 Nov 18;6(11):2067-2072. Epub 2018 Nov 18.

Department of Neurology, Faculty of Medicine, Universitas Gadjah Mada and Dr Sardjito General Hospital, Yogyakarta, Indonesia.

Background: Hyperglycemia is common in acute stroke patients. Hyperglycemia can induce the production of reactive oxygen species, causing increased activity of matrix metalloproteinase-9 (MMP-9).

Aim: This study aimed to determine an association between the increased levels of MMP-9 and the incidence of hyperglycemia in acute ischemic stroke patients. Read More

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http://dx.doi.org/10.3889/oamjms.2018.459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290450PMC
November 2018

Neuroprotective Effects of Purple Sweet Potato Balinese Cultivar in Wistar Rats With Ischemic Stroke.

Open Access Maced J Med Sci 2018 Nov 15;6(11):1959-1964. Epub 2018 Nov 15.

Biopesticide Laboratory, Faculty of Agriculture, Udayana University, Denpasar, Bali, Indonesia.

Background: Purple sweet potato (.) is one of the sources for anthocyanin, which promotes the health through antioxidant, anti-inflammatory, anti-cancer, neuroprotection, and anti-apoptosis activities. Oxidative stress has been shown to be the cause of apoptosis in ischemic stroke. Read More

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http://dx.doi.org/10.3889/oamjms.2018.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290418PMC
November 2018

Analysis of Neutrophil/Lymphocyte ratio and Thiol/Disulfide homeostasis parameters in patients admitted to the emergency department with ischemic stroke.

Pak J Med Sci 2018 Nov-Dec;34(6):1418-1423

Ozcan Erel, MD. Yildirim Beyazit University Medical School, Department of Emergency Medicine, Ankara, Turkey.

Objectives: It is known that the neutrophil/lymphocyte ratio (NLR) is associated with adverse outcomes in ischemic stroke patients. We aimed to reveal the association of NLR and thiol/disulfide homeostasis (TDH) with ischemic stroke patients.

Methods: This study was conducted prospectively at tertiary hospital in emergency department between March 18, 2017 and November 30, 2017. Read More

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http://dx.doi.org/10.12669/pjms.346.16242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290218PMC
December 2018

Progression of Mild to Moderate Stenosis in the Internal Carotid Arteries of Patients With Ischemic Stroke.

Front Neurol 2018 3;9:1043. Epub 2018 Dec 3.

Department of Neurology Chia-Yi Christian Hospital, Chia-Yi, Taiwan.

Severe stenosis in the internal carotid artery may increase the risk of ischemic stroke. The factors that affect the progression of carotid artery stenosis in patients with ischemic stroke are poorly studied. No guidelines for the duration of follow-up of patients with ischemic stroke through carotid ultrasonography exist. Read More

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http://dx.doi.org/10.3389/fneur.2018.01043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287004PMC
December 2018

The Association of Pre-stroke Psychosis and Post-stroke Levels of Health, Resource Utilization, and Care Process: A Register-Based Study.

Front Neurol 2018 3;9:1042. Epub 2018 Dec 3.

Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.

While approximately one percent of the global population is formally diagnosed with psychosis or schizophrenia, the actual number is expected to be significantly higher. These patients often consume more healthcare resources and have poorer somatic health. In this study, we analyze potential differences in health, resources, and care process between stroke patients with and without a previous diagnosis of psychosis or schizophrenia. Read More

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http://dx.doi.org/10.3389/fneur.2018.01042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287012PMC
December 2018

Vessel-Wall Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis.

Front Neurol 2018 3;9:1032. Epub 2018 Dec 3.

Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea.

Vessel-wall magnetic resonance imaging (MRI) has been suggested as a valuable tool for assessing intracranial arterial stenosis with additional diagnostic features. However, there is limited conclusive evidence on whether vessel-wall MR imaging of intracranial atherosclerotic plaques provides valuable information for predicting vulnerable lesions. We conducted this systematic review and meta-analysis to evaluate which characteristics of intracranial-plaque on vessel-wall MRI are markers of culprit lesions. Read More

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http://dx.doi.org/10.3389/fneur.2018.01032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287366PMC
December 2018

Estimating Adherence Based on Prescription or Dispensation Information: Impact on Thresholds and Outcomes. A Real-World Study With Atrial Fibrillation Patients Treated With Oral Anticoagulants in Spain.

Front Pharmacol 2018 3;9:1353. Epub 2018 Dec 3.

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana, Valencia, Spain.

To estimate drug exposure, Proportion of Days Covered (PDC) and percentage of patients with PDC ≥ 80% from a cohort of atrial fibrillation patients initiating oral anticoagulant (OAC) treatment. We employed three different approaches to estimate PDC, using either data from prescription and dispensing (PD cohort) or two common designs based on dispensing information only, requiring at least one (D1) or at least two (D2) refills for inclusion in the cohorts. Finally, we assessed the impact of adherence on health outcomes according to each method. Read More

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http://dx.doi.org/10.3389/fphar.2018.01353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287024PMC
December 2018

Impact of symptomatic atherosclerosis in patients with pulmonary embolism.

Int J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Cardiology I, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Mainz, Germany.

Background: Atherosclerosis is associated with increased cardiovascular mortality. Associations between venous thromboembolism and atherosclerosis were recently reported. We aimed to investigate the impact of symptomatic atherosclerosis on adverse outcomes in patients with pulmonary embolism (PE) and to identify significant differences among patients with PE stratified by symptomatic atherosclerosis. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.12.019DOI Listing
December 2018

Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society.

J Stroke 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Despite the great socioeconomic burden of stroke, there have been few reports of stroke statistics in Korea. In this scenario, the Epidemiologic Research Council of the Korean Stroke Society launched the "Stroke Statistics in Korea" project, aimed at writing a contemporary, comprehensive, and representative report on stroke epidemiology in Korea. This report contains general statistics of stroke, prevalence of behavioral and vascular risk factors, stroke characteristics, pre-hospital system of care, hospital management, quality of stroke care, and outcomes. Read More

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http://dx.doi.org/10.5853/jos.2018.03125DOI Listing
December 2018

Early ST-segment elevation acute myocardial infarction after thrombolytic therapy for acute ischemic stroke: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13347

National Institute of Neurology and Neurovascular Diseases.

Rationale: Acute ST-segment elevation myocardial infarction (STEMI) is a rare complication of acute ischemic stroke (AIS) during thrombolytic therapy. We report a case of STEMI occurring 40 minutes after thrombolytic therapy for AIS and discuss the possible mechanisms and therapeutic approaches.

Patient Concerns: A 87-year-old woman with a history of arterial hypertension was admitted for acute onset of right-sided limb weakness 2 hours before arrival at the emergency department. Read More

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http://dx.doi.org/10.1097/MD.0000000000013347DOI Listing
December 2018

Abnormally high risk of stroke in Brugada syndrome.

J Cardiovasc Med (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Heart Rhythm Management Center, Postgraduate program in Cardiac Electrophysiology and Pacing.

Background: The present study sought to evaluate the incidence of cerebrovascular events in a large cohort of patients with Brugada syndrome (BrS) analysing possible predictors, clinical characteristics and prognosis of cardioembolic events secondary to atrial fibrillation.

Methods: A total of 671 consecutive patients (age 42.1 ± 17. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000723DOI Listing
December 2018
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Evidence-Based Performance Measures and Outcomes in Patients With Acute Ischemic Stroke.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e001968

TianTan Clinical Trial and Research Center for Stroke, Department of Neurology, Beijing TianTan Hospital, Capital Medical University, China (Yilong Wang, Chunjuan Wang, H.L., Yongjun Wang).

Background: Stroke is the leading cause of death in China. Despite the wide dissemination of evidence-based guidelines, data about adherence to these in routine clinical practice are scarce. We conducted a study using a nationwide registry to evaluate the implementation of evidence-based stroke performance indicators and associated guidelines, for patients with an ischemic stroke in China. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.115.001968DOI Listing
December 2018

A Decade of Improvement in Door-to-Needle Time Among Acute Ischemic Stroke Patients, 2008 to 2017.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e004981

Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (X.T., J.L.W., M.G.G., E.C.O., S.M.C.K., T.C., X.Y., R.K.M.).

Background: The clinical benefit of intravenous (IV) alteplase in acute ischemic stroke is time dependent. We assessed the overall temporal changes in door-to-needle (DTN) time and examine the factors associated with DTN time ≤60 and ≤45 minutes.

Methods And Results: A total of 496 336 acute ischemic stroke admissions were identified in the Paul Coverdell National Acute Stroke Program from 2008 to 2017. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004981DOI Listing
December 2018
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The Need for Speed.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e005234

Division of Cardiology, University of California, Los Angeles (G.C.F.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005234DOI Listing
December 2018

Effects of Nursing Quality Improvement on Thrombolytic Therapy for Acute Ischemic Stroke.

Front Neurol 2018 29;9:1025. Epub 2018 Nov 29.

Department of Neurology, The First Hospital of Jilin University, Changchun, China.

Intravenous thrombolytic therapy significantly improves the outcomes of acute ischemic stroke patients in a time-dependent manner. The aim of this study was to investigate whether continuous nursing quality improvement in stroke nurses has a positive effect on reducing the time to thrombolysis in acute ischemic stroke. The implementation of nursing quality improvement measures includes establishing full-time stroke nurses, pre-notification by emergency medical services (EMS), stroke team notification protocols, rapid triage, publicity and education, etc. Read More

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http://dx.doi.org/10.3389/fneur.2018.01025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281878PMC
November 2018

Endothelial Atg7 Deficiency Ameliorates Acute Cerebral Injury Induced by Ischemia/Reperfusion.

Front Neurol 2018 28;9:998. Epub 2018 Nov 28.

Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, Department of Developmental Cell Biology, China Medical University, Shenyang, China.

Ischemic strokes often result in cerebral injury due to ischemia/reperfusion (I/R). Although the local inflammatory responses are known to play a primary role in the brain I/R injury, the underlying mechanism remains unclear. In the current study, we investigated the effect of brain endothelial Atg7 (autophagy related 7) depletion in the acute brain injury induced by ischemia and reperfusion. Read More

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http://dx.doi.org/10.3389/fneur.2018.00998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280951PMC
November 2018

Reduction in the Level of Plasma Mitochondrial DNA in Human Diving, Followed by an Increase in the Event of an Accident.

Front Physiol 2018 29;9:1695. Epub 2018 Nov 29.

Institut de Recherche Biomédicale des Armées, Equipe Résidante de Recherche Subaquatique Opérationnelle, Département Environnement Opérationnel, Unité Environnements Extrêmes, Toulon, France.

Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity or trauma. In the context of decompression sickness (DCS), the course of which is sometimes erratic, we hypothesize that mtDNA plays a not insignificant role particularly in neurological type accidents. This study is based on the comparison of circulating mtDNA levels in humans presenting with various types of diving accidents, and punctured upon their admission at the hyperbaric facility. Read More

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http://dx.doi.org/10.3389/fphys.2018.01695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282000PMC
November 2018

Ratio of End-Systolic Volume to Left Atrial Area Is a Solid Benchmark of Systolic Dysfunction in Non-Ischemic Cardiomyopathies.

Med Sci Monit 2018 Dec 17;24:9144-9150. Epub 2018 Dec 17.

Department of Internal Medicine and Cardiology, J. J. Strossmayer Faculty of Dental Medicine and Health, Osijek, Croatia.

BACKGROUND Impairment of systolic function and late gadolinium enhancement (LGE) are well-known negative prognostic markers in non-ischemic cardiomyopathies (NICMPs). There is limited knowledge of the geometrical rearrangements of the ventricle volumes over size of the left atrium and their connections with systolic dysfunction and existence of LGE. MATERIAL AND METHODS Consecutive cases of NICMPs with impaired systolic function and controls were included from a computerized database of cardiac magnetic resonance exams for a 2. Read More

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http://dx.doi.org/10.12659/MSM.911586DOI Listing
December 2018

Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study.

J Epidemiol 2018 Dec 15. Epub 2018 Dec 15.

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center.

Background: The association of body mass index (BMI) with risks of ischemic stroke subtypes have not been established.

Methods: Cumulative average BMI was calculated using self-reported body weight and height obtained from baseline (Cohort I in 1990, and Cohort II from 1993-1994) and 5- and 10-year questionnaire surveys of Japan Public Health Center-based prospective (JPHC) study. A total of 42,343 men and 46,413 women aged 40-69 years were followed-up for the incidence of lacunar, large-artery occlusive, and cardioembolic strokes. Read More

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http://dx.doi.org/10.2188/jea.JE20170298DOI Listing
December 2018

Sleep Apnea-Predictor of Functional Outcome in Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, KMC Manipal, Karnataka, India.

Background: Sleep apnea is increasingly being recognized as 1 of the important, modifiable risk factors of stroke and cardiovascular diseases. Sleep apnea is thought to impair the functional recovery following stroke. Hence, we evaluated the patients with acute ischemic stroke for prevalence of sleep apnea and compared the functional outcomes of patients with and without sleep apnea, at 3rd month of acute ischemic stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183068
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.030DOI Listing
December 2018
1 Read

Antithrombotic Medication and the Risk of Vitreous Hemorrhage in Atrial Fibrillation: Korean National Health Insurance Service National Cohort.

Yonsei Med J 2019 Jan;60(1):65-72

Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Antithrombotic therapy could be related with nuisance bleeding. This study investigated whether vitreous hemorrhage (VH) is associated with specific types of antithrombotic medication in patients with atrial fibrillation (AF).

Materials And Methods: In the Korean National Health Insurance Service National Sample Cohort, we identified 9352 antiplatelet/anticoagulant-treated AF patients. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.1.65DOI Listing
January 2019
2 Reads

Contralateral acute vascular occlusion following revascularization surgery for moyamoya disease.

Authors:

J Neurosurg 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVERevascularization surgery is a safe and effective surgical treatment for symptomatic moyamoya disease (MMD) and has been shown to reduce the frequency of future ischemic events and improve quality of life in affected patients. The authors sought to investigate the occurrence of acute perioperative occlusion of the contralateral internal carotid artery (ICA) with contralateral stroke following revascularization surgery, a rare complication that has not been previously reported.METHODSThis study is a retrospective review of a prospective database of a single surgeon's series of revascularization operations in patients with MMD. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18951DOI Listing
December 2018
1 Read

Innate T cells in the intensive care unit.

Mol Immunol 2018 Dec 13;105:213-223. Epub 2018 Dec 13.

Brigham and Women's Hospital, Pulmonary and Critical Care Medicine, Boston, MA, 02115, United States; Harvard Medical School, Boston, MA, 02115, United States.

Rapid onset of acute inflammation is a hallmark of critical illnesses that bring patients to the intensive care unit (ICU). In critical illness, innate T cells rapidly reach full activation and drive a robust acute inflammatory response. As "cellular adjuvants," innate T cells worsen inflammation and mortality in several common critical illnesses including sepsis, ischemia-reperfusion injury, stroke, and exacerbations of respiratory disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183083
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http://dx.doi.org/10.1016/j.molimm.2018.09.026DOI Listing
December 2018
2 Reads

Selective Referral Using CCTA Versus Direct Referral for Individuals Referred to Invasive Coronary Angiography for Suspected CAD: A Randomized, Controlled, Open-Label Trial.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, New York. Electronic address:

Objectives: This study compared the safety and diagnostic yield of a selective referral strategy using coronary computed tomographic angiography (CCTA) compared with a direct referral strategy using invasive coronary angiography (ICA) as the index procedure.

Background: Among patients presenting with signs and symptoms suggestive of coronary artery disease (CAD), a sizeable proportion who are referred to ICA do not have a significant, obstructive stenosis.

Methods: In a multinational, randomized clinical trial of patients referred to ICA for nonemergent indications, a selective referral strategy was compared with a direct referral strategy. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.09.018DOI Listing
December 2018

A comparison between physical and biopsychosocial measures of frailty: Prevalence and associated factors in Brazilian older adults.

Arch Gerontol Geriatr 2018 Dec 6;81:111-118. Epub 2018 Dec 6.

National School of Public Health/Oswaldo Cruz Foundation, Department of Epidemiology and Quantitative Methods, Rua Leopoldo Bulhões, 1480/room 817b, Manguinhos, 21041-210 Rio de Janeiro, RJ, Brazil. Electronic address:

Purpose: To estimate the prevalence of frailty, according to Tilburg Frailty Indicator (TFI) and CHS index, to investigate the correlation between both instruments and to identify the factors associated with this condition in older users of primary health care.

Methods: This is a sectional study with 302 individuals aged 60 years or more of Rio de Janeiro/Brazil. Sociodemographic, health, functional dependence and lifestyle variables were collected. Read More

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http://dx.doi.org/10.1016/j.archger.2018.12.003DOI Listing
December 2018

Protective effect of low-intensity transcranial ultrasound stimulation after differing delay following an acute ischemic stroke.

Brain Res Bull 2018 Dec 12. Epub 2018 Dec 12.

Scientific Clinical Specialist, Siemens Ltd., Beijing, China.

Background: Ischemic stroke is a clinically common disease requiring early treatment in the acute period of stroke onset. Such early treatment reduces the level of brain injury, promotes functional recovery, and improves long-term prognosis. Previous studies have demonstrated that, in the event of an acute ischemic stroke, low-intensity transcranial ultrasound stimulation (LITUS) can provide neuroprotection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183072
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http://dx.doi.org/10.1016/j.brainresbull.2018.12.004DOI Listing
December 2018
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Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways.

Exp Neurol 2018 Dec 12. Epub 2018 Dec 12.

Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou 325027, Zhejiang, China. Electronic address:

Dendritic and synaptic plasticity in the penumbra are important processes and are considered to be therapeutic targets of ischemic stroke. Treadmill exercise is known to be a beneficial treatment following stroke. However, its effects and potential mechanism in promoting dendritic and synaptic plasticity remain unknown. Read More

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http://dx.doi.org/10.1016/j.expneurol.2018.12.005DOI Listing
December 2018

MicroRNA-212 promotes the recovery function and vascular regeneration of endothelial progenitor cells in mice with ischemic stroke through inactivation of the notch signaling pathway via downregulating MMP9 expression.

J Cell Physiol 2018 Dec 15. Epub 2018 Dec 15.

Department of Neurology, Cangzhou Central Hospital, Cangzhou, China.

Ischemic stroke is a refractory disease caused by cerebral ischemic injury, which results in brain dysfunction. This study intends to investigate the effects of microRNA-212 (miR-212) on the recovery function and vascular regeneration of endothelial progenitor cells (EPCs) by inactivation of the Notch signaling pathway by binding to matrix metallopeptidase 9 (MMP9) in mice with ischemic stroke. According to the results of database retrieval systems and data analysis, MMP9 was predicted as a gene related to ischemic stroke and miR-212 is a potential regulating mRNA of MMP9. Read More

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http://dx.doi.org/10.1002/jcp.27463DOI Listing
December 2018

Tissue Plasminogen Activator Causes Brain Microvascular Endothelial Cell Injury After Oxygen Glucose Deprivation by Inhibiting Sonic Hedgehog Signaling.

Neurochem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, Renmin Hospital of Wuhan University, No. 9 Zhangzhidong Road, Wuchang District, Wuhan, 430072, Hubei Province, China.

The thrombolytic activity of tissue plasminogen activator (tPA) has undisputed benefits. However, the documented neurotoxicity of tPA raises important issues. Currently, common treatments for stroke might not be optimum if exogenous tPA can pass through the blood-brain barrier and enter the brain, thus adding to the deleterious effects of tPA within the cerebral parenchyma. Read More

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http://dx.doi.org/10.1007/s11064-018-2697-2DOI Listing
December 2018

Multiple biomarkers covering distinct pathways for predicting outcomes after ischemic stroke.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Department of Epidemiology (C.Z., Z.Z., A.W., Tan Xu, X.B., H.P., J.Y., L.H., Tian Xu, Y.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., J.C., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Preventive Medicine (L.H.), Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China; Department of Medicine (J.C., J.H.), Tulane University School of Medicine, New Orleans, LA; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Nantong; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology; Department of Neurology (J.W.), Yutian County Hospital, Tangshan; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Taian; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Tongliao; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.

Objective: To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke.

Methods: We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006717DOI Listing
December 2018

Safety and efficacy of cangrelor in acute stenting for the treatment of cerebrovascular pathology: preliminary experience in a single-center pilot study.

J Neurointerv Surg 2018 Dec 14. Epub 2018 Dec 14.

Lyerly Neurosurgery, Baptist Neurological Institute, Baptist Health, Jacksonville, Florida, USA.

Background: Treatment of acute cerebrovascular pathology, such as acute ischemic stroke or intracranial aneurysms, presents a challenge if an extracranial or intracranial stent is required; immediate platelet inhibition is vital. To date, there is no standardized approach for antiplatelet inhibition in an acute setting.

Objective: To report our preliminary experience and lessons learnt using cangrelor in acute neurointervention. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014396DOI Listing
December 2018

The incidence of carotid in-stent stenosis is underestimated ≥50% or ≥80% and its clinical implications.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

CAMC Health Education and Research Institute, Charleston, WVa.

Background: The incidence of carotid in-stent stenosis has been reported to vary between 1% and 30%. Most published studies have short follow-up, which may lead to underestimation of the incidence of in-stent stenosis. This study analyzed the incidence of ≥50% and ≥80% in-stent stenosis using validated duplex ultrasound criteria and its clinical implications. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.08.185DOI Listing
December 2018

Electroacupuncture Regulates Hippocampal Synaptic Plasticity via Inhibiting Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling in Cerebral Ischemic Rats.

J Stroke Cerebrovasc Dis 2018 Dec 11. Epub 2018 Dec 11.

College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, PR China; Rehabilitation Medical Technology Joint National Local Engineering Research Center, Fuzhou, Fujian, PR China.

Objective: To determine the mechanism(s) involved in electroacupuncture (EA)-mediated improvements in synaptic plasticity in a rat model of middle cerebral artery occlusion and reperfusion (MCAO/R)-induced cognitive deficits.

Methods: Focal cerebral ischemic stroke was induced by (MCAO/R) surgery. Rats were randomly split into 4 groups: control group (sham operation control), MCAO group, Baihui (GV 20) and Shenting (GV 24) acupoint EA group (verum acupuncture, MCAO + VA), and nonacupoint EA group (control acupuncture, MCAO + CA). Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.025DOI Listing
December 2018

Disparities in Inter-hospital Helicopter Transportation for Hispanics by Geographic Region: A Threat to Fairness in the Era of Thrombectomy.

J Stroke Cerebrovasc Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, University of Iowa, Iowa City, Iowa; Department of Neurosurgery, University of Iowa, Iowa City, Iowa; Department of Epidemiology, University of Iowa, Iowa City, Iowa. Electronic address:

Background And Purpose: Mechanical thrombectomy (MT) is a time-dependent therapy that is only available at a limited number of hospitals. As such, patients that live at a considerable distance of those specialized centers often require rapid interhospital emergent evacuation with Helicopter Emergency Medical Services (HEMS) to be considered for MT. It is not known whether the use of HEMS is equitable across different groups of patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183061
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.031DOI Listing
December 2018
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Neuroprotective agents in Acute Ischemic Stroke-A Reality Check.

Biomed Pharmacother 2019 Jan 5;109:2539-2547. Epub 2018 Dec 5.

Department of Clinical Pharmacology, SRM Medical College Hospital & Research Centre, Kattankulathur, Chennai, Tamil Nadu, 603203 India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183639
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http://dx.doi.org/10.1016/j.biopha.2018.11.041DOI Listing
January 2019
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The protective effect of zeranol in cerebral ischemia reperfusion via p-CREB overexpression.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt. Electronic address:

Aims: Cerebral ischemia reperfusion (I/R) is a neurovascular disease leading to cerebral damage. It was found that postmenopausal women are liable to more dangerous effects than men at same age in stroke. The objective of this study is to investigate the neuroprotective effect of zeranol against cerebral ischemia reperfusion in ovariectomized rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.017DOI Listing
December 2018

A New Model to Predict Ischemic Stroke in Patients with Atrial Fibrillation Using Warfarin or Direct Oral Anticoagulants.

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.

Background: Stroke risk stratification scores (e.g., CHADS-VASc) are used to tailor therapeutic recommendations for patients with atrial fibrillation (AF) in different risk groups. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.12.005DOI Listing
December 2018
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The role of neurogenesis in neurorepair after stroke.

Semin Cell Dev Biol 2018 Dec 11. Epub 2018 Dec 11.

Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address:

Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. Read More

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http://dx.doi.org/10.1016/j.semcdb.2018.12.003DOI Listing
December 2018
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Mean Platelet Volume in Patients with Acute Ischemic Stroke with Nonvalvular Atrial Fibrillation.

Clin Lab 2018 Oct;64(11)

Background: Platelets play an important role in the pathogenesis of vascular disease, and the size of the platelets can determine their reactivity. Large platelets secrete more prothrombotic factors and aggregate more quickly. In this study, we aimed to investigate mean platelet volume (MPV) levels, which are considered to be an indication of the increase in platelet function in previous studies, in cases of acute ischemic stroke (AIS) with nonvalvular atrial fibrillation (NVAF). Read More

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October 2018
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Hemofiltration for neuroprotection in acute ischemic stroke: a prospective, pilot study.

Acta Neurol Scand 2018 Dec 13. Epub 2018 Dec 13.

National Research Oncology and Transplantation Center, Astana, Kazakhstan.

Background: Hemofiltration reduces blood levels of cytokines, glutamate and other substances that increase the risk of stroke-associated neurodegeneration. This study aimed to assess the safety and efficacy of hemofiltration in acute ischemic stroke patients.

Methods: 37 patients (mean age 56±16 years) who had an ischemic stroke within the previous 12 hours were randomized to receive hemofiltration for 36 hours (n=19) or standard treatment (n=18). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13060
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http://dx.doi.org/10.1111/ane.13060DOI Listing
December 2018
1 Read