86,968 results match your criteria Stroke Ischemic


Yangyin Tongnao granules enhance neurogenesis in the peri-infarct area and upregulate brain-derived neurotrophic factor and vascular endothelial growth factor after focal cerebral ischemic infarction in rats.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Yangyin Tongnao granules (YYTNG) have been extensively applied in the treatment of brain injury, mainly due to its antioxidant effects, inhibition of apoptosis, and enhancement of blood circulation. To analyze the effect of YYTNG on the recovery of neurological function and neurogenesis in the peri-infarct area after cerebral ischemic infarction in rats and to elucidate its role in the neuroprotective mechanism of stroke, Sprague-Dawley (SD) rats were subjected to middle cerebral artery occlusion (MCAO) for 90 min followed by reperfusion. Rats were randomly divided into five groups: sham, MCAO, and YYTNG-treated rats given doses of 0. Read More

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http://dx.doi.org/10.1007/s11033-019-04824-5DOI Listing

Effect of G-CSF on the Spatial Arrangement of CA1 Hippocampal Pyramidal Neurons after Brain Ischemia in the male Rats.

J Chem Neuroanat 2019 Apr 18. Epub 2019 Apr 18.

Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Stroke is a leading cause of mortality and disability; Memory impairment occurs frequently after stroke and the pattern of hippocampal CA1 pyramidal neurons has important role in the signal transmission and memory forming. G-CSF (granulocyte-colony stimulating factor) is a novel treatment that exhibits neuroprotective and anti-apoptotic in the central nervous system. The aim of the present study was to determine the effects of G-CSF on the neurobehavioral outcome and spatial pattern of CA1 pyramidal neurons after focal cerebral ischemia in animals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08910618183020
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http://dx.doi.org/10.1016/j.jchemneu.2019.04.007DOI Listing
April 2019
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Risk Factors for Pressure Sores in Hospitalized Acute Ischemic Stroke Patients.

J Stroke Cerebrovasc Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China.

Background: Acute ischemic stroke patients are a group at high risk for pressure sores. It is important to identify risk factors for pressure sores in acute ischemic stroke patients in order to facilitate early adoption of appropriate preventive and treatment measures.

Methods: Data were derived from the China National Stroke Registry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057193008
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.033DOI Listing
April 2019
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Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial.

J Stroke Cerebrovasc Dis 2019 Apr 18. Epub 2019 Apr 18.

Departments of Neurology, Tokai University School of Medicine, Isehara, Tokyo, Japan. Electronic address:

Background: Nonvitamin K antagonist oral anticoagulants (NOACs) are considered superior, or at least noninferior, to warfarin in preventing stroke or systemic embolism in patients with nonvalvular atrial fibrillation. Here, we recruited acute ischemic stroke patients with nonvalvular atrial fibrillation and at least one cerebral microbleed (CMB), and evaluated the proportion of patients who had an increased number of CMBs (%) after receiving anticoagulant therapy with NOACs or with warfarin for 12 months.

Methods: This was a multicenter, prospective, observational cohort study at 20 centers, conducted between 2015 and 2017, in which we recruited 85 patients with at least one CMB detected by 1. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.050DOI Listing

ERK activation by zeranol has neuroprotective effect in cerebral ischemia reperfusion.

Life Sci 2019 Apr 18. Epub 2019 Apr 18.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Aims: Incidence of stroke increases in postmenopausal women with dangerous consequences. In this study we used zeranol to protect ovariectomized (OVX) rats against cerebral I/R damage and our target is to identify the mechanism of its protection, in addition to investigating whether this mechanism inhibits inflammation (by preventing glial cell activation) and apoptosis.

Main Methods: First 18 ovariectomized rats were allocated into 3 groups: I/R group, zeranol+ I/R group and U0126, MEK1/2 inhibitor + zeranol+ I/R group. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.035DOI Listing

Left Atrial Mechanical Function and Incident Ischemic Cerebrovascular Events Independent of AF.

JACC Cardiovasc Imaging 2019 Apr 10. Epub 2019 Apr 10.

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Objectives: This study sought to assess the association of baseline left atrial (LA) phasic function measured with cardia magnetic resonance (CMR) and incident ischemic cerebrovascular events (CVE).

Background: LA remodeling is a known predictor of atrial fibrillation (AF), which is a risk factor for ischemic CVE. Despite studies showing an association between LA remodeling and ischemic CVE, the association of LA mechanical function with ischemic CVE in a population free of known cardiovascular disease is not fully studied. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.02.021DOI Listing

Bleeding risk assessment for stroke patients on antithrombotic therapy.

Clin Investig Arterioscler 2019 Apr 17. Epub 2019 Apr 17.

Unidad de Gestión Clínica de Cuidados Críticos y Urgencias, Hospital Virgen Macarena, Sevilla, España.

Introduction: After an ischemic cerebrovascular event the risk of new ischemic events is high, therefore antithrombotic therapy are indicated to prevent stroke recurrence.

Discussion: Despite its clear benefit, these therapies increase the risk of bleeding. Therefore, it is essential to identify high hemorrhagic risk patients. Read More

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http://dx.doi.org/10.1016/j.arteri.2019.01.006DOI Listing

Acute cerebellar stroke and middle cerebral artery stroke exert distinctive modifications on functional cortical connectivity: A comparative study via EEG graph theory.

Clin Neurophysiol 2019 Apr 6;130(6):997-1007. Epub 2019 Apr 6.

Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Neurology, Area of Neuroscience, Catholic University of The Sacred Heart, Rome, Italy.

Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms.

Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193011
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http://dx.doi.org/10.1016/j.clinph.2019.03.017DOI Listing
April 2019
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Dose reduction of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: A Danish nationwide cohort study.

Thromb Res 2019 Apr 9;178:101-109. Epub 2019 Apr 9.

Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Kildegaardsvej 28, 2900 Hellerup, Denmark.

Introduction: To investigate the patterns of dose reduction of non-vitamin K antagonist oral anticoagulants (NOAC) in patients with atrial fibrillation (AF).

Materials And Methods: Using Danish nationwide registries, we identified all non-valvular AF patients initiated on standard-dose NOAC during 2011-2017 who were followed until dose reduction. The absolute risk of dose reduction was presented as cumulative incidence both overall and according to baseline characteristics. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.04.007DOI Listing

miR-124 upregulates astrocytic glutamate transporter-1 via the Akt and mTOR signaling pathway post ischemic stroke.

Brain Res Bull 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, People's Republic of China. Electronic address:

High-concentration glutamic acid (Glu) induced by ischemic stroke can be inhibited by glutamate transporter-1 (GLT-1), which is the main mechanism for preventing excessive extracellular glutamate accumulation in the central nervous system. Upregulation of miR-124 could reduce the infarct area and promote the recovery of neurological function after ischemic stroke. A previous study investigated whether miR-124 could regulate GLT-1 expression in normal culture conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183060
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.013DOI Listing
April 2019
2 Reads

Alterations in Cortical Morphology after Neonatal Stroke: Compensation in the Contralesional Hemisphere?

Dev Neurobiol 2019 Apr 20. Epub 2019 Apr 20.

Université d'Angers, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), EA, 7315, 49000, Angers, France.

Although neonatal arterial ischemic Stroke is now well-studied, its complex consequences on long-term cortical brain development has not yet been solved. In order to understand the brain development after focal early brain lesion, brain morphometry needs to be evaluated using structural parameters. In this work, our aim was to study and analyse the changes in morphometry of ipsi- and contralesional hemispheres in seven-year-old children following neonatal stroke. Read More

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http://dx.doi.org/10.1002/dneu.22679DOI Listing

Toward neuroimaging-based network biomarkers for transient ischemic attack.

Hum Brain Mapp 2019 Apr 19. Epub 2019 Apr 19.

Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou, China.

Stroke is associated with topological disruptions of large-scale functional brain networks. However, whether these disruptions occur in transient ischemic attack (TIA), an important risk factor for stroke, remains largely unknown. Combining multimodal MRI techniques, we systematically examined TIA-related topological alterations of functional brain networks, and tested their reproducibility, structural, and metabolic substrates, associations with clinical risk factors and abilities as diagnostic and prognostic biomarkers. Read More

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http://dx.doi.org/10.1002/hbm.24602DOI Listing

Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization.

Basic Res Cardiol 2019 Apr 19;114(3):25. Epub 2019 Apr 19.

Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, 46202, USA.

The goal of the present study was to evaluate the effects of SGLT2i on cardiac contractile function, substrate utilization, and efficiency before and during regional myocardial ischemia/reperfusion injury in normal, metabolically healthy swine. Lean swine received placebo or canagliflozin (300 mg PO) 24 h prior to and the morning of an invasive physiologic study protocol. Hemodynamic and cardiac function measurements were obtained at baseline, during a 30-min complete occlusion of the circumflex coronary artery, and during a 2-h reperfusion period. Read More

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http://link.springer.com/10.1007/s00395-019-0733-2
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http://dx.doi.org/10.1007/s00395-019-0733-2DOI Listing
April 2019
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On the simulation of mitral valve function in health, disease, and treatment.

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

Gorman Cardiovascular Research Group, Department of Surgery, University of Pennsylvania, Philadelphia, PA.

The mitral valve (MV) is the heart valve that regulates blood ?ow between the left atrium and left ventricle (LV). In situations where the MV fails to fully cover the left atrioventricular ori?ce during systole, the resulting regurgitation causes pulmonary congestion, leading to heart failure and/or stroke. The causes of MV insuf?ciency can be either primary (e. Read More

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http://biomechanical.asmedigitalcollection.asme.org/article.
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http://dx.doi.org/10.1115/1.4043552DOI Listing
April 2019
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Inflammatory cytokines and ischemic stroke risk: The REGARDS cohort.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Departments of Pathology and Laboratory Medicine (N.S.J., N.A.Z., M.C.) and Medicine (N.A.Z., M.C.), University of Vermont Larner College of Medicine, Burlington; Department of Biometry (P.W.C.), University of Vermont, Burlington; Department of Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; and Department of Neurology and Rehabilitation Medicine (B.K.), University of Cincinnati College of Medicine, OH.

Objective: We studied circulating interleukin (IL)-6, IL-8, and IL-10 concentrations and incident ischemic stroke risk in a biracial cohort, and determined if these cytokines mediated the racial disparity in stroke incidence affecting the black population.

Methods: The Reasons for Geographic and Racial Differences in Stroke study enrolled 30,237 black and white men and women age ≥45 in 2003-2007. We measured baseline IL-6, IL-8, and IL-10 in a case-cohort study of 557 participants with incident stroke over 5. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007416DOI Listing

MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Department of Neurology (J.M.-F., L.P.-S., R.M., R.D.-M., A.M.-D., P.C.-R., E.J.-X.) and Epidemiology (I.G.), Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, Barcelona; Departments of Radiology (S.M.-M.) and Neurology (A.R.-C.), Hospital del Mar-Parc de Salut Mar, Barcelona; Unitat RM IDI (E.M.) and Department of Neurosciences (M.H.-P.), Hospital Germans Trias i Pujol, Badalona; Department of Neurology (M.Z.), Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy; Department of Neurology (M.G.-C.), Hospital de Sant Joan Despí Moises Broggi, Sant Joan Despí, Spain; Department of Neurology (L. Lara), Hospital de León; Department of Neurology (A.B.), Hospital Universitari Son Espases, Palma de Mallorca; Department of Neurology (A.C.), Hospital de Valladolid; Department of Neurology (A.M.D.A.-B.), Hospital de Donostia; Department of Neurology (Y.B.), Hospital de Burgos; Department of Neurology (B.F.), Hospital Universitario La Paz, Universidad Autónoma de Madrid, Instituto de Investigación IdiPaz, Madrid; Department of Neurology (D. Cánovas), Hospital Parc Taulí, Sabadell; Department of Neurology (L. Llull), Hospital Clínic, Barcelona; Department of Neurology (B.Z.), Hospital de Navarra, Pamplona; Department of Neurology (M.F.), Hospital de Basurto, Bilbao; Department of Neurology (I.C.-N.), Hospital San Pedro de Alcántara, Cáceres; Department of Neurology (J.S.), Hospital Arnau de Vilanova, Lleida; Department of Neurology (D. Cocho), Hospital de Granollers; Department of Neurology (J.K.), F.Ass. Mutua Terrassa; Department of Neurology (E.P.), Hospital de Mataró; Department of Neurology (A.D.F.), Hospital Ramón y Cajal, Madrid; Department of Neurology (M.S.), Hospital La Rioja, Logroño; Department of Neurology (E.Z.-A.), Hospital Virgen del Rocío, Sevilla; Department of Neurology (J.Z.-B.), Hospital Verge de la Cinta, Tortosa; Department of Neurology (I.D.-M.), Hospital de Albacete; Department of Neurology (J.F.-D.), Centro Médico Asturias, Oviedo; Department of Neurology (A.L.), Hospital La Fe, Valencia; Department of Neurology (J.M.), Hospital Virgen de las Nieves, Granada; and Department of Neurology (M.R.-Y.), Hospital Santiago de Compostela, Santiago de Compostela, Spain.

Objective: We tested the hypothesis that the risk of intracranial hemorrhage (ICH) in patients with cardioembolic ischemic stroke who are treated with oral anticoagulants (OAs) can be predicted by evaluating surrogate markers of hemorrhagic-prone cerebral angiopathies using a baseline MRI.

Methods: Patients were participants in a multicenter and prospective observational study. They were older than 64 years, had a recent cardioembolic ischemic stroke, and were new users of OAs. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007532DOI Listing
April 2019
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Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Neuroradiology, Istanbul Faculty of Medicine, Istanbul, Turkey.

Purpose: To identify the frequency of epilepsy and whether the association of epilepsy with clinical and neuroimaging findings in children with presumed perinatal arterial ischemic stroke (PPAIS).

Methods: We performed a retrospective analysis of 37 children with PPAIS followed-up at a tertiary referral center between January 1, 2000, and October 31, 2016. Clinical data including demographic features, age at onset of symptoms and seizures, initial clinical presentation, epilepsy features, used antiepileptic drugs, and thrombophilia screening results were abstracted from medical records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604193009
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http://dx.doi.org/10.1016/j.braindev.2019.04.004DOI Listing
April 2019
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NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, China. Electronic address:

Aims: NLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was involved in regulating and activating the IL-23/IL-17 axis in ischaemic stroke. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.031DOI Listing

RTN1-C is involved in high glucose-aggravated neuronal cell subjected to oxygen-glucose deprivation and reoxygenation injury via endoplasmic reticulum stress.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. Electronic address:

Background: Patients suffering from diabetes mellitus experience poor outcomes after ischemic stroke. RTN1-C, ER-associated proteins localized in endoplasmic reticulum (ER) membrane, plays an important role in ER stress-induced apoptosis and regulates cellular susceptibility to different apoptosis pathways. Overexpression of RTN1-C can aggravate cerebral ischemia/reperfusion injury (IRI). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.010DOI Listing

Protective Effects of Mesenchymal Stem Cells Overexpressing Extracellular Regulating Kinase 1/2 Against Stroke in Rats.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Shanghai Tongji hospital, Tongji University School of Medicine, Shanghai, 200065, China. Electronic address:

Objective: Although transplantation of bone marrow-derived mesenchymal stem cells (MSCs) has shown beneficial effects on stroke, lower survival of MSCs limits effects. Extracellular regulating kinase 1/2 signaling (ERK1/2) is crucial for cell survival, differentiation, and proliferation. This study was designed to explore whether MSCs modified by over-expressing ERK1/2 may reinforce beneficial effects on stroke in rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183021
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.006DOI Listing
April 2019
1 Read

IgM antibodies against phosphorylcholine measured early after acute ST-elevation myocardial infarction in relation to atherosclerotic disease burden and long-term clinical outcome.

PLoS One 2019 19;14(4):e0215640. Epub 2019 Apr 19.

Department of Cardiology, Oslo University Hospital, Oslo, Norway.

Purpose: Studies have reported an association between low levels of natural immunoglobulin M antibodies against phosphorylcholine(IgM anti-PC) and worse prognosis in patients with coronary artery disease (CAD). The aims of the present study were, in patients with ST-elevation myocardial infarction (STEMI); 1) to compare serum levels of IgM anti-PC measured acutely and after 3 months; 2) to study an association between levels of IgM anti-PC and the severity ofCAD, and; 3) to investigate whether IgM anti-PC levels are associated with long-term clinical outcome.

Methods: A total of 213 patients without known diabetes (median age 59 years) with a PCI treated STEMI were enrolled. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215640PLOS
April 2019
3 Reads

Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study.

Eur J Neurol 2019 Apr 19. Epub 2019 Apr 19.

Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

Background: The association between an increased supraventricular ectopic beat (SVEB) and subclinical cerebrovascular disease remains unclear. Given the emerging concept that an increased SVEB is a marker of atrial cardiomyopathy or atherosclerosis burden, we sought to determine whether excessive supraventricular ectopic activity (ESVEA) is associated with a higher burden of subclinical cerebrovascular disease in the middle-aged to older cohort with neither apparent stroke nor atrial fibrillation.

Methods: We conducted a cross-sectional population-based study of 462 men (mean age, 68. Read More

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http://dx.doi.org/10.1111/ene.13970DOI Listing

Endovascular Treatment for Acute Ischemic Stroke: Clinical Outcomes Under Pressure.

Eur J Neurol 2019 Apr 19. Epub 2019 Apr 19.

Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Current guidelines from the European Stroke Organisation (ESO) and the European Society for Minimally Invasive Neurological Therapy (ESMINT) on the endovascular treatment (EVT) for large vessel occlusion (LVO) patients with acute ischemic stroke (AIS) suggest to maintain blood pressure (BP) levels below 180/105 mmHg both during and for 24 hours after EVT, however grading this recommendation as weak due to the low quality of existing evidence. The association between functional outcomes following EVT and the various BP parameters, measured hourly during the first 24 hours after admission, was further investigated in the retrospective analysis of 378 LVO patients by Cho et al. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13969
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http://dx.doi.org/10.1111/ene.13969DOI Listing
April 2019
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Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants.

JAMA Netw Open 2019 Apr 5;2(4):e192696. Epub 2019 Apr 5.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations.

Objectives: To evaluate the association of diabetes with all-cause and cause-specific mortality in Asia and to investigate potential effect modifications of the diabetes-mortality associations by participants' age, sex, education level, body mass index, and smoking status. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2696DOI Listing
April 2019
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Aspirin reduced recurrent stroke risk in patients with lacunar stroke.

Acta Neurol Scand 2019 Apr 19. Epub 2019 Apr 19.

Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100037, China.

Objectives: Lacunar stroke had an unfavorable prognosis in the long term with a high risk of recurrent stroke, aspirin has been widely used to prevent ischemic stroke, but data on the effect of antiplatelet therapy on lacunar infarction are limited. We investigated the long-term effect of aspirin treatment on stroke recurrence risk in patients with lacunar stroke in a multicenter prospective cohort.

Methods: Between November 2000 and November 2001, 2000 consecutive stroke patients (age 35-74 years) were recruited from seven clinical centers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13105
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http://dx.doi.org/10.1111/ane.13105DOI Listing
April 2019
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Utilization and safety of extracranial-intracranial bypass surgery in symptomatic steno-occlusive disorders.

Brain Circ 2019 Jan-Mar;5(1):32-35. Epub 2019 Mar 27.

Department of Neurology, UT Health McGovern School of Medicine, Houston, Texas, USA.

Objective: The objective of this study was to investigate patterns of utilization and safety of extracranial-intracranial (EC-IC) bypass in patients with symptomatic cerebrovascular steno-occlusive disorders.

Methods: Patients with one of the steno-occlusive conditions (defined as symptomatic intracranial stenosis, extracranial stenosis, and moyamoya disease) were identified using all nonfederal hospitalizations in New York (2005-2014) and Florida (2005-2015). EC-IC bypass surgery was defined using the corresponding procedure codes. Read More

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http://dx.doi.org/10.4103/bc.bc_33_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458777PMC

Early signs of middle cerebral artery infarction on multidetector computed tomography: Review of 20 cases.

Brain Circ 2019 Jan-Mar;5(1):27-31. Epub 2019 Mar 27.

Department of Diagnostic Radiologic Technology, College of Applied Medical Sciences, Taibah University, Almadinah Almunawarah, Medina, Saudi Arabia.

Objective: This study intended to assess the occurrence of early signs of middle cerebral artery (MCA) on multidetector computed tomography (MDCT) in correlation with duration of the clinical features of stroke.

Patients And Methods: This retrospective study analyzed the electronic records of 20 patients with MCA infarction. The detected signs studied according to the onset of the clinical features of stroke to the time of CT imaging. Read More

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http://dx.doi.org/10.4103/bc.bc_28_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458774PMC

Treatment for ischemic stroke: From thrombolysis to thrombectomy and remaining challenges.

Brain Circ 2019 Jan-Mar;5(1):8-11. Epub 2019 Mar 27.

Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.

Stroke is a leading cause of death and long-term disabilities. Despite decades of extensive efforts in search of brain injury mechanisms and therapeutic interventions, pharmacological treatment is limited to the use of thrombolytic agent tissue plasminogen activator, which has limited therapeutic time window and potential side effect of intracranial hemorrhage. Over the past few years, endovascular thrombectomy with stent-retriever devices combined with advanced imaging modalities has transformed the standard of stroke care, offering an opportunity to improve the outcome in selected patients as late as 24 h after the onset of stroke. Read More

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http://www.braincirculation.org/text.asp?2019/5/1/8/255026
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http://dx.doi.org/10.4103/bc.bc_36_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458775PMC
March 2019
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Autoimmunity After Ischemic Stroke and Brain Injury.

Front Immunol 2019 2;10:686. Epub 2019 Apr 2.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tolerance mechanisms. In stroke patients, the detection of T cells and antibodies specific to neuronal antigens suggests a role of humoral adaptive immunity. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00686
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http://dx.doi.org/10.3389/fimmu.2019.00686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454865PMC
April 2019
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Endovascular Treatment of Acute Stroke Due to Intracranial Atherosclerotic Stenosis-Related Large Vessel Occlusion.

Front Neurol 2019 2;10:308. Epub 2019 Apr 2.

Interventional Neuroradiology, Department of Radiology, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Endovascular treatment (EVT) has become a standard treatment for acute ischemic stroke due to large vessel occlusion (LVO) in the anterior circulation. However, whether EVT tools used for intracranial atherosclerotic stenosis (ICAS)-related LVO are as safe and effective as for use in embolic LVO remains unclear. There have been only a few studies about EVT for ICAS-related LVO, and these studies revealed that mechanical thrombectomy with a stent retriever or contact aspiration was less effective and more time consuming in ICAS-related LVO than in embolic LVO. Read More

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http://dx.doi.org/10.3389/fneur.2019.00308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454085PMC

The Role of High Mobility Group Box 1 in Ischemic Stroke.

Front Cell Neurosci 2019 2;13:127. Epub 2019 Apr 2.

Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

High-mobility group box 1 protein (HMGB1) is a novel, cytokine-like, and ubiquitous, highly conserved, nuclear protein that can be actively secreted by microglia or passively released by necrotic neurons. Ischemic stroke is a leading cause of death and disability worldwide, and the outcome is dependent on the amount of hypoxia-related neuronal death in the cerebral ischemic region. Acting as an endogenous danger-associated molecular pattern (DAMP) protein, HMGB1 mediates cerebral inflammation and brain injury and participates in the pathogenesis of ischemic stroke. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00127
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http://dx.doi.org/10.3389/fncel.2019.00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454008PMC
April 2019
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Meningeal Mast Cells as Key Effectors of Stroke Pathology.

Front Cell Neurosci 2019 3;13:126. Epub 2019 Apr 3.

Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.

Stroke is the leading cause of adult disability in the United States. Because post-stroke inflammation is a critical determinant of damage and recovery after stroke, understanding the interplay between the immune system and the brain after stroke holds much promise for therapeutic intervention. An understudied, but important aspect of this interplay is the role of meninges that surround the brain. Read More

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http://dx.doi.org/10.3389/fncel.2019.00126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457367PMC

Symptomatic Extracranial Carotid Artery Thrombus: An Indian Experience.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):312-315

Division of Stroke and Interventional Neurology and Department of Neurology, NH Institute of Neurosciences, Narayana Health City, Bengaluru, Karnataka, India.

Introduction: Symptomatic intraluminal carotid artery thrombus (ICT) is an uncommon finding, whose incidence increases with the percentage of stenosis. The optimal treatment modality to address carotid artery thrombus is not well established. We present our data of medical management of carotid artery thrombus with antiplatelet and anticoagulation. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/312/254
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http://dx.doi.org/10.4103/jnrp.jnrp_225_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454977PMC
April 2019
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Extended Window for Stroke Thrombectomy.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):294-300

Department of Neurological Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA.

Objective: Mechanical thrombectomy is the standard treatment for large vessel occlusion (LVO) in acute ischemic stroke (AIS) up to 6 h after onset. Recent trials have demonstrated a benefit for wake-up strokes and patients beyond 6 h.

Methods: A systematic literature review was conducted for multicenter randomized clinical trials (RCTs) investigating endovascular stroke treatment using perfusion imaging to identify patients that may benefit from mechanical thrombectomy for AIS beyond 6 h of onset. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/294/254
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http://dx.doi.org/10.4103/jnrp.jnrp_365_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454953PMC
April 2019
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Dietary pattern in Adult Patients with Acute Stroke in South India: A Case-Control Study from a Tertiary Care Center in Hyderabad.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):283-293

Department of Neurology, Princess Esra Hospital, Deccan College of Medical Science, Hyderabad, Telangana, India.

Background And Objective: Diet plays a crucial role in the occurrence of stroke. But very few studies have so far been conducted with focus on this aspect of acute stroke in India. The objective of the study was to identify the dietary pattern in patients with acute stroke in South India. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_237_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454960PMC

Is Prevalence of Hypertension Increasing in First-Ever Stroke Patients?: A Hospital-Based Cross-Sectional Study.

Ann Neurosci 2018 Dec 25;25(4):219-222. Epub 2018 Jul 25.

Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Background: Stroke is a devastating and disabling cerebrovascular disease with some amount of residual deficit leading to economic loss. Recent Indian studies have shown a stroke prevalence rate of 471.58/100,000 populations. Read More

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http://dx.doi.org/10.1159/000487066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470354PMC
December 2018

Study of Ischemia Modified Albumin as a Biomarker in Acute Ischaemic Stroke.

Ann Neurosci 2018 Dec 28;25(4):187-190. Epub 2018 Jun 28.

Narayana Medical College and Hospitals, Nellore, India.

Background And Purpose: Stroke is one of the leading causes of mortality and long-term disability. Prompt diagnosis and treatment of stroke are crucial for a better outcome. A blood test, which serves as a biomarker in rural areas will help in immediately transferring patients to a hospital for thrombolytic therapy. Read More

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http://dx.doi.org/10.1159/000488188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470340PMC
December 2018

Protective cardiac conditioning by an atypical cytokine.

Clin Sci (Lond) 2019 Apr 18;133(8):933-937. Epub 2019 Apr 18.

Chair of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), Munich 81377, Germany

Ischemic heart disease (IHD) represents the leading cause of morbidity and mortality worldwide. Therapy options generally aim at restoring the blood flow to the heart muscle and relieve the ischemic insult. Paradoxically, coronary artery reperfusion itself, both during emergency intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20190036
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http://dx.doi.org/10.1042/CS20190036DOI Listing
April 2019
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Increasing the Risk of Stroke by Opium Addiction.

J Stroke Cerebrovasc Dis 2019 Apr 15. Epub 2019 Apr 15.

Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA. Electronic address:

Introduction: Stroke is among the leading causes of mortality and morbidity in the world. Besides the identified risk factor, Ischemic stroke evidence show drug use develops or exacerbates the atherosclerotic process. The current study aimed at comparing cerebrovascular ultrasounds' changes in addicted and nonaddicted people who developed ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.044DOI Listing

Short- and long-term follow-up of antithrombotic management patterns in patients hospitalized with acute coronary syndrome: Indian subgroup of EPICOR Asia study.

Indian Heart J 2019 Jan - Feb;71(1):25-31. Epub 2019 Jan 3.

Ruby Hospital, Pune, India.

Background: Acute coronary syndrome (ACS) is associated with emergency hospitalizations, and there are limited real-world data on clinical outcomes in post-ACS Asian patients. This article presents data on the Indian subgroup from the Long-term Follow-up of Antithrombotic Management Patterns in Acute Coronary Syndrome Patients in Asia (EPICOR-Asia) study.

Methods: EPICOR included patients with ACS [ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), or unstable angina (UA)]. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00194832183035
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http://dx.doi.org/10.1016/j.ihj.2018.12.005DOI Listing
January 2019
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Contemporary Outcomes Following Coronary Artery Bypass Graft Surgery for Left Main Disease.

J Am Coll Cardiol 2019 Apr;73(15):1877-1886

Department of Cardiology, Imperial College of London, London, United Kingdom. Electronic address:

Background: Although results of percutaneous coronary intervention (PCI) have been steadily improving, whether surgical outcomes have improved over time is not fully elucidated.

Objectives: This study sought to compare the current outcomes of patients undergoing coronary artery bypass grafting (CABG) with prior surgical results, in the context of randomized trials including the left main (LM) coronary artery stem.

Methods: The authors performed a propensity-matched analysis of patients randomized to CABG in the SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) (enrollment period 2005 to 2007) and EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) (enrollment period 2010 to 2014) trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097193369
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http://dx.doi.org/10.1016/j.jacc.2018.12.090DOI Listing
April 2019
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16.503 Impact Factor

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.

J Biomed Sci 2019 Apr 18;26(1):27. Epub 2019 Apr 18.

Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu Hsing St., Taipei, 110, Taiwan.

Background: Promoting post-stroke neurogenesis has long been proposed to be a therapeutic strategy for the enhancement of functional recovery after cerebral ischemic stroke. Despite numerous approaches have been widely reported the proliferation or differentiation of the neurogenic population therapeutic strategies by targeting adult neurogenesis not yet to be successfully clarified in clinical settings. Here, we hypothesized that alterations in microenvironment of the ischemic brain might impede the functional maturation of adult newly generated neurons that limits functional recovery after stroke. Read More

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http://dx.doi.org/10.1186/s12929-019-0521-1DOI Listing
April 2019
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A Retrospective Study Investigating: Factors associated with mode of arrival and emergency department management for patients with acute stroke.

Australas Emerg Care 2018 Aug 17;21(3):99-104. Epub 2018 Aug 17.

University of Melbourne, Department of Medicine, Australia; Royal Melbourne Hospital, Emergency Department, Australia. Electronic address:

Background: Presentation by ambulance to the emergency department is critical for stroke patients to receive time dependent treatments. However, little is known of the factors that influence presentation by ambulance.

Methods: Retrospective analysis of all patients with an emergency department medical diagnosis of stroke who presented to one of three Victorian emergency departments over a three-year period (2011-2013). Read More

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http://dx.doi.org/10.1016/j.auec.2018.07.001DOI Listing

Impact of Race and Ethnicity on the Clinical and Angiographic Characteristics, Social Determinants of Health, and 1-Year Outcomes After Everolimus-Eluting Coronary Stent Procedures in Women.

Circ Cardiovasc Interv 2019 Apr;12(4):e006918

Interventional Heart Program, Inova Health System, Inova Heart & Vascular Institute, Falls Church, VA (W.B.).

Background The impact of race/ethnicity on coronary stent outcomes in women is unknown. We compared baseline characteristics, social determinants of health, and 1-year outcomes in female African Americans (AA) and Hispanic/Latinas (HL) versus white women after coronary everolimus-eluting stent implantation in all-comer patients. Methods and Results We pooled 1863 women from the PLATINUM Diversity (n=1057 women) and PROMUS ELEMENT PLUS (n=806 women) postapproval studies, with some overlap in study sites. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006918DOI Listing
April 2019
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Investigation of the relationship between ischemic stroke and endothelial nitric oxide synthase gene polymorphisms [G894T, intron 4 VNTR and T786C]

Turk J Med Sci 2019 Apr 18;49(2):589-594. Epub 2019 Apr 18.

Background/aim: We aimed to investigate the associations between endothelial nitric oxide synthase(eNOS) gene polymorphisms [G894T (rs1799983)], intron 4 (27-bpTR) variable number tandem repeat (VNTR) and T786C (rs2070744), and ischemic stroke in the Anatolian population.

Materials And Methods: This case-control study included 112 patients with “stroke of undetermined etiology” and 160 controls. Real-time polymerase chain reaction (RT-PCR) analysis was used to analyze these polymorphisms. Read More

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http://dx.doi.org/10.3906/sag-1808-57DOI Listing

Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemic stroke: A meta-analysis.

Mol Genet Genomic Med 2019 Apr 17:e643. Epub 2019 Apr 17.

Department of General Practice, Shanghai Pudong New District Dongming Community Healthcare Center, Shanghai, China.

Background: Recently, associations between intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and ischemic stroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta-analysis was performed to better assess the relationship between ICAM-1rs5498 polymorphism and IS.

Methods: PubMed, Medline, Embase, and CNKI were searched for eligible studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.643
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http://dx.doi.org/10.1002/mgg3.643DOI Listing
April 2019
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Adverse Outcomes Associated with Pre-Existing and New-Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome: A Retrospective Cohort Study.

Cardiol Ther 2019 Apr 17. Epub 2019 Apr 17.

Cardiovascular Department, Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Introduction: Atrial fibrillation (AF) often occurs in patients with acute coronary syndrome (ACS). It remains unclear whether pre-existing or new-onset AF confers different risk in patients with ACS.

Methods: We conducted a retrospective cohort study using Taiwan's National Health Insurance Research Database. Read More

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http://dx.doi.org/10.1007/s40119-019-0136-3DOI Listing
April 2019
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Comparative Study of Back Propagation Artificial Neural Networks and Logistic Regression Model in Predicting Poor Prognosis after Acute Ischemic Stroke.

Open Med (Wars) 2019 4;14:324-330. Epub 2019 Apr 4.

The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan, Qingyuan China.

Objective: To investigate the predictive value of clinical variables on the poor prognosis at 90-day follow-up from acute stroke onset, and compare the diagnostic performance between back propagation artificial neural networks (BP ANNs) and Logistic regression (LR) models in predicting the prognosis.

Methods: We studied the association between clinical variables and the functional recovery of 435 acute ischemic stroke patients. The patients were divided into 2 groups according to modified Rankin Scale scores evaluated on the 90th day after stroke onset. Read More

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http://dx.doi.org/10.1515/med-2019-0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463818PMC

Apical hypertrophic cardiomyopathy with preexcitation presenting as a myocardial infarction and ischemic stroke with a history of recurrent syncope: A case report.

Clin Case Rep 2019 Apr 14;7(4):816-820. Epub 2019 Mar 14.

Centre for Research and Development Uppsala University/Region Gävleborg Gävle Sweden.

Contrast-enhanced echocardiography or cardiac magnetic resonance imaging is of value in the diagnosis of apical hypertrophic cardiomyopathy. Apical hypertrophic cardiomyopathy is rare in Caucasians, and gene negativity does not rule out the diagnosis. Risk stratification for sudden cardiac death and decisions about anticoagulation in cases with atrial fibrillation should be based on guidelines. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2104
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http://dx.doi.org/10.1002/ccr3.2104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452448PMC
April 2019
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[Spinal cord stimulation for non-reconstructable chronic ritical limb ischemiae: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):362-364

Department of Vascular Surgery, Peking University People's Hospital, Beijing 100044, China.

Peripheral arterial disease is one part of systematic atherosclerosis, becoming a heavy burden of human health. Patients in end stage of peripheral arterial disease manifest critical limb ischemia with severe rest pain and refractory ulcer. Surgical revascularization is the optimal option for patients with critical limb ischemia to avoid major amputation and improve quality of life. Read More

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April 2019
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