128,585 results match your criteria Stroke Ischemic


Clinical Characteristics and Functional Outcomes of Wake-Up Stroke in the Chinese Population.

Eur Neurol 2020 Jun 3:1-9. Epub 2020 Jun 3.

Department of Neurology, Panzhihua Municipal Central Hospital, Panzhihua, China,

Background: Wake-up stroke (WUS) accounts for up to 25% of all new ischemic strokes, but debate exists regarding whether WUS differs from non-WUS in previous studies. Our study aimed to investigate the proportion of WUS cases and to examine differences in clinical characteristics and outcomes in these two groups.

Methods: Data from acute ischemic stroke patients who presented to the First Affiliated Hospital of Chongqing Medical University between April 2017 and September 2017 were prospectively collected. Read More

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http://dx.doi.org/10.1159/000506198DOI Listing

Assessment of the reporting quality of double-blind RCTs for ischemic stroke based on the CONSORT statement.

J Neurol Sci 2020 May 27;415:116938. Epub 2020 May 27.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Background-purpose: It is critical that Randomized Controlled Trials(RCTs) present complete and transparent reporting. The present study aims to determine the reporting quality of double-blind RCTs for medicinal interventions in patients with ischemic stroke, based on the 2010 CONSORT-statement.

Methodology: MEDLINE was comprehensively searched. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116938DOI Listing

Oral Anticoagulants and Antiplatelet Agents in Patients With Atrial Fibrillation and Concomitant Critical Limb Ischemia: A Nationwide Cohort Study.

Can J Cardiol 2020 Feb 19. Epub 2020 Feb 19.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.

Background: Evidence of clinical outcomes for oral anticoagulants and antiplatelet treatment (APT) in patients with atrial fibrillation (AF) and critical limb ischemia (CLI) is very limited.

Methods: In this nationwide retrospective cohort study collected from Taiwan National Health Insurance Research Database, 1223 patients with AF and CLI taking direct-acting oral coagulants (DOACs), warfarin, or APT were identified from June 1, 2012, to December 31, 2017. We used propensity score stabilized weighting (PSSW) to balance covariates across study groups. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.02.071DOI Listing
February 2020

Impact of body mass index on procedural complications, procedure duration, and radiation dose in patients with atrial fibrillation undergoing radiofrequency ablation: A systematic review and meta-analysis.

Clin Cardiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, China.

Background: The association of body mass index (BMI) and procedure-related factors in patients with atrial fibrillation (AF) after radiofrequency ablation (RFA) is still unclear.

Hypothesis: BMI is associated with increased the radiation dose, procedure duration, and procedural complications.

Methods: Prospective studies assessing BMI and procedure duration, radiation dose, and procedural complications in patients with AF after RFA were identified through electronic searches of PubMed, Embase, and the Cochrane Library database. Read More

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http://dx.doi.org/10.1002/clc.23398DOI Listing

Increased microvascular permeability and low level of low-density lipoprotein cholesterol predict symptomatic intracerebral hemorrhage in acute ischemic stroke.

Sci Prog 2020 Apr-Jun;103(2):36850420924153

Department of General Internal Medicine, The First Hospital of Jilin University, Changchun, China.

Symptomatic intracerebral hemorrhage is a serious potential complication of recombinant tissue-type plasminogen activator thrombolysis in acute ischemic stroke. We investigated the optimal imaging and clinical parameters to predict symptomatic intracerebral hemorrhage in acute ischemic stroke patients after recombinant tissue-type plasminogen activator therapy. We retrospectively reviewed 151 acute ischemic stroke patients with thrombolytic therapy, who were dichotomized into symptomatic intracerebral hemorrhage group and non-symptomatic intracerebral hemorrhage group. Read More

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http://dx.doi.org/10.1177/0036850420924153DOI Listing

Clinical and molecular correlates of the ASPECTS in the acute phase of stroke.

Arq Neuropsiquiatr 2020 May 29;78(5):262-268. Epub 2020 May 29.

Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Background: The Alberta Stroke Program Early CT Score (ASPECTS) scale was developed for monitoring early ischemic changes on CT, being associated with clinical outcomes. The ASPECTS can also associate with peripheral biomarkers that reflect the pathophysiological response of the brain to the ischemic stroke.

Objective: To investigate the association between peripheral biomarkers with the Alberta Stroke Program Early CT Score (ASPECTS) in individuals after ischemic stroke. Read More

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http://dx.doi.org/10.1590/0004-282x20200001DOI Listing

Pterostilbene alleviates cerebral ischemia and reperfusion injury in rats by modulating microglial activation.

Food Funct 2020 Jun 3. Epub 2020 Jun 3.

College of Life and Health Sciences, Northeastern University, Shenyang, China. and Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang, China.

Ischemic stroke is a severe neurological disease without known effective therapy. Microglia-mediated neuroinflammation plays an important role in ischemic stroke. Therefore, finding a safe and effective microglial activation inhibitor might lead to an effective therapeutic strategy against ischemic stroke. Read More

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http://dx.doi.org/10.1039/d0fo00084aDOI Listing

Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups.

Int J Cardiol Heart Vasc 2020 Jun 29;28:100538. Epub 2020 May 29.

Departments of Medicine, University of Illinois at Chicago, USA.

Background: Although traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objective of this study was to determine the role played by race- and sex-specific risk factors in AF outcomes in non-Hispanic blacks (NHBs), Hispanics/Latinos (H/Ls), and non-Hispanic whites (NHWs). Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262442PMC

Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases.

Data Brief 2020 Aug 22;31:105744. Epub 2020 May 22.

Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.

The data presented here are related to the research article entitled "Differential expression of the angiotensin-(1-12) [Ang-(1-12)]/chymase axis in human atrial tissue [1]. We have showed that chymase gene transcripts, chymase activity, and immunoreactive- Ang-(1-12) expression levels were higher in left compared to right atrial tissue, irrespective of cardiac disease. This article presents the echocardiographic characteristics of 111 patients undergoing heart surgery for the correction of valvular heart disease, resistant atrial fibrillation or ischemic heart disease. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256457PMC

Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective.

Glob Heart 2020 Feb 12;15(1):15. Epub 2020 Feb 12.

Department of Medicine, Harvard Medical School, Boston, US.

Non-communicable diseases (NCDs) are the second common cause of death in sub-Saharan Africa (SSA) accounting for about 35% of all deaths, after a composite of communicable, maternal, neonatal, and nutritional diseases. Despite prior perception of low NCDs mortality rates, current evidence suggests that SSA is now at the dawn of the epidemiological transition with contemporary double burden of disease from NCDs and communicable diseases. In SSA, cardiovascular diseases (CVDs) are the most frequent causes of NCDs deaths, responsible for approximately 13% of all deaths and 37% of all NCDs deaths. Read More

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http://dx.doi.org/10.5334/gh.403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218780PMC
February 2020

The Correlation of Routine Hematological Parameters with In-hospital Mortality and Length of Hospital Stay in Patients with Large Middle Cerebral Artery Infarction.

Authors:
Muzaffer Güneş

Cureus 2020 Apr 29;12(4):e7886. Epub 2020 Apr 29.

Neurology, Aksaray University Training and Research Hospital, Aksaray, TUR.

Objective Neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) reflect inflammation and these parameters have not been studied in patients with large cerebral artery infarction. This study investigated the correlation of these inflammation parameters with in-hospital mortality and length of hospital stay (LOS) in patients with large middle cerebral artery (MCA) infarction. Materials and methods The study was conducted with patients who had large MCA (M1 and M2 segments) infarction. Read More

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http://dx.doi.org/10.7759/cureus.7886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255539PMC

Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury.

Aging Dis 2020 May 9;11(3):523-535. Epub 2020 May 9.

2The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.

Neuroinflammation plays a critical role in ischemia-induced brain injury. Mib2, an E3 ubiquitin ligase, has been reported to regulate Notch signaling and participate in the peripheral immune system. However, the roles of Mib2 in the nervous system are not well characterized. Read More

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http://dx.doi.org/10.14336/AD.2019.0807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220279PMC

Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats.

Iran J Basic Med Sci 2020 Apr;23(4):494-499

Department of Critical Care Medicine, Yu Huang Ding Hospital, Qingdao University, Yantai, P. R. China.

Objectives: This study aimed to evaluate the potential role of hydrogen in rats after cerebral ischemic/reperfusion (I/R) injury.

Materials And Methods: The experimental samples were composed of sham group, model group of rats that received middle cerebral artery occlusion (MCAO) for 2 hr followed by reperfusion for 24 hr, and the hydrogen saline group treated by hydro¬gen-rich saline (1 ml/kg) after MCAO. Hydrogen sulfide (H2S), S100-βprotein (S100-β), and neuron-specific enolase (NSE) levels were measured; the levels of malondialdehyde (MDA), reactive oxygen species (ROS), and superoxide dismutase (SOD) were detected; the histologic structure and apoptotic cells of hippocampus were observed; the expressions of cystathionine β-synthase (CBS), nuclear factor erythroid 2-related factor 2 (Nrf2), and hemeoxygenase-1 (HO-1) were measured. Read More

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http://dx.doi.org/10.22038/ijbms.2020.41751.9857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239416PMC

Safety and Efficacy of Oral Anticoagulants Therapies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-Analysis.

J Cardiovasc Pharmacol Ther 2020 Jun 3:1074248420930136. Epub 2020 Jun 3.

Department of Pharmacy, Federal University of Paraná, Curitiba, Brazil.

Background: Different antithrombotic treatments, from vitamin K antagonists to direct oral anticoagulants (DOACs), are available to reduce ischemic risks in patients with atrial fibrillation (AF) after percutaneous coronary intervention (PCI).

Objective: To synthetize evidence about the benefit-risk ratio of antithrombotic treatments and their combinations in patients with AF and PCI.

Methods: A network meta-analysis and a stochastic multicriteria acceptability analysis (SMAA) were performed including randomized controlled trials (RCT) that evaluate antithrombotic treatments in adults with AF and PCI. Read More

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http://dx.doi.org/10.1177/1074248420930136DOI Listing

Association of diabetes with stroke and post-stroke dementia: A population-based cohort study.

Alzheimers Dement 2020 Jun 2. Epub 2020 Jun 2.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

Introduction: The impact of prediabetes and diabetes on stroke and the development of dementia after a stroke remain unclear.

Methods: A total of 2655 dementia-free participants (including a stroke-free cohort and a prevalent stroke cohort) were followed-up for 12 years. Dementia and post-stroke dementia were determined by clinical examinations and national registry data. Read More

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http://dx.doi.org/10.1002/alz.12101DOI Listing

Transcranial Doppler Emboli Monitoring for Infective Endocarditis.

J Neuroimaging 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Wake Forest Baptist Medical Center, Winston-Salem, NC.

Background And Purpose: Ischemic stroke can occur in 20-55% of patients with infective endocarditis (IE) with 75% occurring during the first 2 weeks of treatment. CT or MRI brain can diagnose the sequelae of stroke but transcranial Doppler (TCD) can document active embolization. We undertook a retrospective review of our patient cohort and a systematic review of literature to assess the role of TCD in early diagnosis and management of ischemic stroke in IE. Read More

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http://dx.doi.org/10.1111/jon.12721DOI Listing

Ephrin-Eph Signaling as a Novel Neuroprotection Path in Ischemic Stroke.

J Mol Neurosci 2020 Jun 2. Epub 2020 Jun 2.

College of Pharmacy, Pharmaceutical Sciences Department, Larkin University, 18301 N Miami ave, Miami, FL, 33169, USA.

The search for novel neuroprotection strategies in ischemic stroke continues, as revascularization using tissue-plasminogen activator is the only pharmacological method currently available to patients. The purpose of this review article is to summarize research findings regarding the erythropoietin-producing hepatocellular receptor pathway as an emerging novel molecular target for neuroprotection in ischemic stroke. Ephrin-Eph interactions represent a new strategy in neuroprotection. Read More

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http://dx.doi.org/10.1007/s12031-020-01603-xDOI Listing

Global burden of noncommunicable disease attributable to high body mass index in 195 countries and territories, 1990-2017.

Endocrine 2020 Jun 2. Epub 2020 Jun 2.

Department of Endocrinology and Metabolism, the Second Affiliated Hospital of ZheJiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.

Purpose: The increasing burden of noncommunicable diseases (NCDs) attributable to high body mass index (BMI) represents both a threat and an opportunity for intervention. Estimates of the global latest trend of high BMI-related NCDs and its association with socioeconomic status can facilitate strategic intervention and inform further research.

Methods: This global burden of disease study extracted global, regional, and national data on death and disability-adjusted life years (DALYs) attributable to high BMI-related NCDs from the GBD Study 2017. Read More

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http://dx.doi.org/10.1007/s12020-020-02352-yDOI Listing

Heart failure patients have enhanced cerebral autoregulation response in acute ischemic stroke.

J Thromb Thrombolysis 2020 Jun 1. Epub 2020 Jun 1.

Cardiovascular Research and Development Center, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal.

The cerebrovascular effects of a failing heart-pump are largely unknown. Chronic heart failure (HF) might cause pre-conditioning effect on cerebral hemodynamics but not study so far in acute stroke. We aimed to investigate if HF induces effects in dynamic cerebral autoregulation (CA), within 6 h of symptom-onset through chronic stage of ischemic stroke. Read More

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http://dx.doi.org/10.1007/s11239-020-02166-9DOI Listing

A high-fat diet rich in corn oil exaggerates the infarct size and memory impairment in rats with cerebral ischemia and is associated with suppressing osteopontin and Akt, and activating GS3Kβ, iNOS, and NF-κB.

J Physiol Biochem 2020 Jun 2. Epub 2020 Jun 2.

Department of Medical Physiology, College of Medicine, King Khalid University, P.O. Box 3340, 61421, Abha, Kingdom of Saudi Arabia.

The increase in osteopontin (OPN) levels after stroke induces neural protection by activating Akt signaling and inhibiting GS3Kβ, iNOS, and NF-κB. This study investigated the effect of a high-fat diet rich in corn oil (CO-HFD) on infarct size and memory function in rats after induction of cerebral ischemia in rats and investigated its effect on the expression of OPN/Akt/iNOS/NF-κB signaling pathways. Rats were initially fed a standard diet (STD, 3. Read More

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http://dx.doi.org/10.1007/s13105-020-00744-2DOI Listing

Newly developed stroke in patients admitted to non-neurological intensive care units.

J Neurol 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Background: Little is known about newly developed stroke in patients admitted to the intensive care unit (ICU).

Objective: This study aimed to investigate characteristics and outcomes of newly developed stroke in patients admitted to the non-neurological intensive care units (ICU-onset stroke, IOS).

Methods: A consecutive series of adult patients who were admitted to the non-neurological ICU were included in this study. Read More

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http://dx.doi.org/10.1007/s00415-020-09955-5DOI Listing

Icariside II attenuates cerebral ischemia/reperfusion-induced blood-brain barrier dysfunction in rats via regulating the balance of MMP9/TIMP1.

Acta Pharmacol Sin 2020 Jun 2. Epub 2020 Jun 2.

Department of Pharmacology, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.

Cerebral ischemia/reperfusion (I/R) results in harmful consequences during ischemic stroke, especially the disruption of the blood-brain barrier (BBB), which leads to severe hemorrhagic transformation through aggravation of edema and brain hemorrhage. Our previous study demonstrated that icariside II (ICS II), which is derived from Herba Epimedii, attenuates cerebral I/R injury by inhibiting the GSK-3β-mediated activation of autophagy both in vitro and in vivo. However, the effect of ICS II on the BBB remains unclear. Read More

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http://dx.doi.org/10.1038/s41401-020-0409-3DOI Listing

Local anesthesia versus general anesthesia during endovascular therapy for acute stroke: a propensity score analysis.

J Neurointerv Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Diagnostic and Interventional Neuroradiology, University Hospital Centre Nancy, Nancy, Lorraine, France.

Background: To date, the choice of optimal anesthetic management during endovascular therapy (EVT) of acute ischemic stroke patients remains subject to debate. We aimed to compare functional outcomes and complication rates of EVT according to the first-line anesthetic management in two comprehensive stroke centers: local anesthesia (LA) versus general anesthesia (GA).

Methods: Retrospective analysis of prospectively collected databases, identifying all consecutive EVT for strokes in the anterior circulation performed between January 1, 2018 and December 31, 2018 in two EVT-capable stroke centers. Read More

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http://dx.doi.org/10.1136/neurintsurg-2020-015916DOI Listing

Leukoaraiosis and acute ischemic stroke: 90-day clinical outcome following endovascular recanalization, with proposed "L-ASPECTS".

J Neurointerv Surg 2020 Jun 2. Epub 2020 Jun 2.

Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Background: To assess if leukoaraiosis severity is associated with outcome in patients with acute ischemic stroke (AIS) following endovascular thrombectomy, and to propose a leukoaraiosis-related modification to the ASPECTS score.

Methods: A retrospective review was completed of AIS patients that underwent mechanical thrombectomy for anterior circulation large vessel occlusion. The primary outcome measure was 90-day mRS. Read More

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http://dx.doi.org/10.1136/neurintsurg-2020-015957DOI Listing

Incidence of Acute Ischemic Stroke With Visible Arterial Occlusion: A Population-Based Study (Dijon Stroke Registry).

Stroke 2020 Jun 3:STROKEAHA120029949. Epub 2020 Jun 3.

Dijon Stroke Registry, EA7460, Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases (PEC2), Department of Neurology, University of Burgundy, University Hospital of Dijon, France.

Background And Purpose: Because of several methodological limitations, previous studies focusing on the prevalence of large vessel occlusion in ischemic stroke (IS) patients provided conflicting results. We evaluated the incidence of IS with a visible arterial occlusion using a comprehensive population-based registry.

Methods: Patients with acute IS were prospectively identified among residents of Dijon, France, using a population-based registry (2013-2017). Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029949DOI Listing

Efficacy and Safety of Recanalization Therapy for Acute Ischemic Stroke With Large Vessel Occlusion: A Systematic Review.

Stroke 2020 Jun 3:STROKEAHA119028624. Epub 2020 Jun 3.

Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Beijing, China. (C.W., W.Z., X.J.).

Background And Purpose: The optimal recanalization strategy for acute ischemic stroke with large vessel occlusion continues to be an area of active interest. Network meta-analysis can provide insight when direct comparative evidence is lacking.

Methods: A systematic review of the literature using PubMed, Embase, the Cochrane Central Register of Controlled Trials, and SinoMed was performed, and a search was conducted for clinical trials on ClinicalTrials. Read More

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http://dx.doi.org/10.1161/STROKEAHA.119.028624DOI Listing

Baseline Serum Bilirubin and Risk of First Stroke in Hypertensive Patients.

J Am Heart Assoc 2020 Jun 3:e015799. Epub 2020 Jun 3.

National Clinical Research Center for Kidney Disease the State Key Laboratory for Organ Failure Research Renal Division Nanfang Hospital Southern Medical University Guangzhou China.

Background Data on the association between serum bilirubin and the risk of stroke are limited and inconclusive. We aimed to evaluate the association between serum bilirubin and the risk of first stroke and to examine any possible effect modifiers in hypertensive patients. Methods and Results Our study was a post hoc analysis of the CSPPT (China Stroke Primary Prevention Trial). Read More

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http://dx.doi.org/10.1161/JAHA.119.015799DOI Listing

High neutrophil-to-lymphocyte ratio is associated with poor clinical outcome in patients with critically ill stroke.

Minerva Anestesiol 2020 May 29. Epub 2020 May 29.

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China -

Background: This study aims to evaluate the relationship between inflammatory markers on admission and clinical outcome in patients with critically ill stroke.

Methods: We retrospectively extracted data from our prospectively organized database of consecutive adult patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) admitted to our neurocritical care unit (NCU) within 72 hours of the onset between Jan 2013 and Dec 2017. From white blood cell (WBC) counts, levels of C-reactive protein (CRP) and albumin obtained on admission, we calculated neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein-to-albumin ratio (CAR). Read More

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http://dx.doi.org/10.23736/S0375-9393.20.14310-4DOI Listing

NF-κB and tPA Signaling in Kidney and Other Diseases.

Cells 2020 May 29;9(6). Epub 2020 May 29.

Nephrology Research Program, Department of Medicine, Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating homeostasis of blood coagulation, fibrinolysis, and matrix degradation, has been shown to act as a cytokine to trigger profound receptor-mediated intracellular events, modulate the NF-κB pathway, and mediate organ dysfunction and injury. In this review, we focus on the current understanding of NF-κB and tPA signaling in the development and progression of kidney disease. Read More

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http://dx.doi.org/10.3390/cells9061348DOI Listing

β-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke.

Int J Mol Sci 2020 May 29;21(11). Epub 2020 May 29.

Department of Medical Research, Taichung Veterans General Hospital, Taichung City 407, Taiwan.

Chronic treatment involving opioids exacerbates both the risk and severity of ischemic stroke. We have provided experimental evidence showing the anti-inflammatory and neuroprotective effects of the μ opioid receptor antagonist β-funaltrexamine for neurodegenerative diseases in rat neuron/glia cultures and a rat model of cerebral Ischemia/Reperfusion (I/R) injury. Independent of in vitro Lipopolysaccharide (LPS)/interferon (IFN-γ)-stimulated neuron/glia cultures and in vivo cerebral I/R injury in Sprague-Dawley rats, β-funaltrexamine downregulated neuroinflammation and ameliorated neuronal degeneration. Read More

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http://dx.doi.org/10.3390/ijms21113866DOI Listing

Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies.

Int J Mol Sci 2020 May 29;21(11). Epub 2020 May 29.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research Raebareli (NIPER-R), Near CRPF Base Camp, Post Office Mati, Sarojini Nagar, Lucknow (U.P.) 226002, India.

Heavy metals are considered a continuous threat to humanity, as they cannot be eradicated. Prolonged exposure to heavy metals/metalloids in humans has been associated with several health risks, including neurodegeneration, vascular dysfunction, metabolic disorders, cancer, etc. Small blood vessels are highly vulnerable to heavy metals as they are directly exposed to the blood circulatory system, which has comparatively higher concentration of heavy metals than other organs. Read More

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http://dx.doi.org/10.3390/ijms21113862DOI Listing

Improved reperfusion following alternative surgical approach for experimental stroke in mice.

F1000Res 2020 13;9:188. Epub 2020 Mar 13.

School of Psychology, University of Nottingham, Nottingham, NG7 2UH, UK.

: Following ischemic stroke, recanalisation and restoration of blood flow to the affected area of the brain is critical and directly correlates with patient recovery.  models of ischemic stroke show high variability in outcomes, which may be due to variability in reperfusion.  We previously reported that a surgical refinement in the middle cerebral artery occlusion (MCAO) model of stroke, via repair of the common carotid artery (CCA), removes the reliance on the Circle of Willis for reperfusion and reduced infarct variability. Read More

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http://dx.doi.org/10.12688/f1000research.22594.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217225PMC

Elevated level of cerebrospinal fluid and systemic chemokine CCL5 is a predictive biomarker of clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH).

Cytokine 2020 May 30;133:155142. Epub 2020 May 30.

Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf, Germany; Department of Neurosurgery, University Hospital Bonn, University of Bonn, D-53105 Bonn, Germany; Department of Neurosurgery, University Hospital Helsinki, University of Helsinki, FI-00029 Helsinki, Finland; Department of Anatomy and Developmental Biology, Center for Biomedicine and Medical Technology Mannheim (CBTM) and European Center for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, D-68167 Mannheim, Germany. Electronic address:

Background: Pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH) is highly complex. Bleeding from ruptured aneurysm causes increase in intracranial pressure that disrupts blood-brain barrier leading to infiltration of peripheral immune cells. Interactions between the infiltrated leukocytes and the resident brain cells in the injured tissue mainly determine the delayed tissue damage. Read More

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http://dx.doi.org/10.1016/j.cyto.2020.155142DOI Listing

Randomized trial of argatroban plus recombinant tissue-type plasminogen activator for acute ischemic stroke (ARAIS): Rationale and design.

Am Heart J 2020 Apr 8;225:38-43. Epub 2020 Apr 8.

Department of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. Electronic address:

Background: Previous studies have implied the efficacy and safety of argatroban plus recombinant tissue-type plasminogen activator (r-tPA) in patients with acute ischemic stroke. Further trials are needed to establish convincing conclusions in a large sample size.

Research Design And Methods: Argatroban plus r-tPA for Acute Ischemic Stroke (ARAIS) trial is a multicenter, prospective, randomized, open-label, and blind-end point trial. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.04.003DOI Listing

The association between serum uric acid level and the risk of cognitive impairment after ischemic stroke.

Neurosci Lett 2020 May 30:135098. Epub 2020 May 30.

Department of Neurology, The Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317000, China; Department of Neurology, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, 317000, China. Electronic address:

Post-stroke cognitive impairment (PSCI) is a severe complication of stroke. Predicting PSCI is difficult because some risk factors for stroke, such as blood glucose level and blood pressure, are affected by many other elements. Although recent studies have shown that high serum uric acid (UA) levels are associated with cognitive dysfunction and may be a risk factor for PSCI, its impact remains unclear. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135098DOI Listing

Meta-analysis of matrix metalloproteinase (MMP)-9 C1562T polymorphism and susceptibility to ischemic stroke in the Chinese population.

J Int Med Res 2020 Jun;48(6):300060520926427

Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Objective: Many studies have shown that the C1562T polymorphism in the matrix metalloproteinase (MMP)-9 gene promoter is associated with susceptibility to ischemic stroke (IS), but the association between them remains controversial. Our objective was to explore the relationship between C1562T polymorphism and susceptibility to IS in the Chinese population.

Methods: We conducted a database search of Wanfang, China Science and Technology Journal database, China National Knowledge Infrastructure, Medline, Embase, PubMed and Springerlink through September 2019. Read More

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http://dx.doi.org/10.1177/0300060520926427DOI Listing

Association Between Thrombolytic Door-to-Needle Time and 1-Year Mortality and Readmission in Patients With Acute Ischemic Stroke.

JAMA 2020 Jun;323(21):2170-2184

Division of Cardiology, University of California, Los Angeles.

Importance: Earlier administration of intravenous tissue plasminogen activator (tPA) in acute ischemic stroke is associated with reduced mortality by the time of hospital discharge and better functional outcomes at 3 months. However, it remains unclear whether shorter door-to-needle times translate into better long-term outcomes.

Objective: To examine whether shorter door-to-needle times with intravenous tPA for acute ischemic stroke are associated with improved long-term outcomes. Read More

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http://dx.doi.org/10.1001/jama.2020.5697DOI Listing

Long-term Outcomes After Thrombolytic Therapy for Acute Ischemic Stroke.

JAMA 2020 Jun;323(21):2184-2185

Senior Editor, , Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2020.5269DOI Listing

Collateral Status at Single-Phase and Multiphase CT Angiography versus CT Perfusion for Outcome Prediction in Anterior Circulation Acute Ischemic Stroke.

Radiology 2020 Jun 2:192029. Epub 2020 Jun 2.

From the Jiangsu Key Laboratory of Molecular and Functional Imaging and Center of Interventional Radiology and Vascular Surgery, Departments of Radiology (Z.W., T.Y.T., C.H.Z., Y.Z., Z.Z., D.L.Z., G.D., S.H.J., G.J.T.), and Neurology (J.X., L.Y.G., Z.J.Z.), Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Rd, Nanjing 210009, China.

Background Collateral status assessed with single- or multiphase CT angiography can be used to predict outcome in patients with acute ischemic stroke (AIS); however, little is known about whether these measures could be comparable with CT perfusion parameters. Purpose To compare the predictive ability of collateral score systems assessed with single- or multiphase CT angiography and CT perfusion parameters in determining clinical outcomes in patients with AIS. Materials and Methods In this retrospective study, data obtained from October 2017 to August 2018 in consecutive patients with AIS caused by isolated anterior circulation large artery occlusion and that were obtained within 24 hours after onset were reviewed. Read More

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http://dx.doi.org/10.1148/radiol.2020192029DOI Listing

Multicolor spectral photon counting CT monitors and quantifies therapeutic cells and their encapsulating scaffold in a model of brain damage.

Nanotheranostics 2020 22;4(3):129-141. Epub 2020 Apr 22.

CarMeN Laboratory, Institut National de la Santé et de la Recherche Médicale U1060, INRA U1397, Université Lyon 1, INSA Lyon, F-69600 Oullins, France.

: Various types of cell therapies are currently under investigation for the treatment of ischemic stroke patients. To bridge the gap between cell administration and therapeutic outcome, there is a need for non-invasive monitoring of these innovative therapeutic approaches. Spectral photon counting computed tomography (SPCCT) is a new imaging modality that may be suitable for cell tracking. Read More

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http://dx.doi.org/10.7150/ntno.45354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256015PMC

Ticagrelor alone or conventional dual antiplatelet therapy in patients with stable or acute coronary syndromes.

EuroIntervention 2020 Jun 2. Epub 2020 Jun 2.

Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.

Aims: To investigate the effect of ticagrelor monotherapy after 1-month dual antiplatelet therapy (DAPT) or conventional DAPT in patients with or without acute coronary syndrome (ACS) in the GLOBAL LEADERS Adjudication Sub-Study (GLASSY).

Methods And Results: Risk estimates were expressed as rate ratios (RR) with 95% confidence intervals (CI). A total of3,840 ACS and 3,745 SIHD (stable ischemic heart disease) patients were included. Read More

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http://dx.doi.org/10.4244/EIJ-D-20-00145DOI Listing

Structural heart intervention for prevention of embolic and hemorrhagic stroke: The new field of neurocardiology.

J Cardiol 2020 May 29. Epub 2020 May 29.

Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan.

Cardiogenic stroke (CS), characteristic causes of which include atrial fibrillation (AF) and right-to-left shunting due to a patent foramen ovale (PFO), has a well-known tendency to be associated with a more extensive ischemic area. This may result in severe neurological damage, and require strict life-long antithrombotic therapy. However, the fact that some patients have problems complying with the requirement for extended oral antithrombotic treatment has motivated the development of alternative approaches for stroke prevention. Read More

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http://dx.doi.org/10.1016/j.jjcc.2020.04.007DOI Listing

Structural Connectomics: State of the Art and Applications in Pediatric Neurodevelopmental Disorders, Neuro-Oncology, and Arterial Ischemic Stroke.

J Pediatr 2020 Jun;221S:S37-S42

Edward B. Singleton Department of Radiology, Section of Pediatric Neuroradiology, Texas Children's Hospital, Houston, TX.

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http://dx.doi.org/10.1016/j.jpeds.2020.01.056DOI Listing

Treadmill Exercise Improves Motor Function and Short-term Memory by Enhancing Synaptic Plasticity and Neurogenesis in Photothrombotic Stroke Mice.

Int Neurourol J 2020 May 31;24(Suppl 1):S28-38. Epub 2020 May 31.

School of Global Sport Studies, Korea University, Sejong, Korea.

Purpose: Thrombotic stroke is a type of ischemic stroke characterized by motor dysfunction and memory impairments. In the present study, the effect of treadmill exercise on motor function and short-term memory was evaluated in relation with synaptic plasticity in the mice with photothrombotic stroke.

Methods: Photothrombotic stroke was induced by cortical photothrombotic vascular occlusion. Read More

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http://dx.doi.org/10.5213/inj.2040158.079DOI Listing

Evaluating Effectiveness and Safety in Chronic Kidney Disease with Atrial Flutter Using an Anticoagulation Strategy.

Medicina (Kaunas) 2020 May 28;56(6). Epub 2020 May 28.

Division of Gastroenterology, Department of Internal Medicine, Taitung MacKay Memorial Hospital, Taitung 95054, Taiwan.

Recent randomized trials of oral antithrombotic drugs with atrial flutter (AFL) excluded patients with renal impairment because of their increased risk of bleeding. To date, no relevant studies have assessed the effectiveness and safety of different antithrombotic drugs in chronic kidney disease (CKD) patients with AFL. This cohort study evaluated the effectiveness and safety of different antithrombotic drugs in CKD patients with AFL. Read More

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http://dx.doi.org/10.3390/medicina56060266DOI Listing

Impact of transcranial Doppler sonography for detecting ischemic stroke: A protocol of systematic review and meta-analysis.

Medicine (Baltimore) 2020 May;99(22):e20451

Department of Neurology, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Background: This study aims to explore the impact of transcranial Doppler sonography (TDS) for detecting ischemic stroke (IS).

Methods: PUBMED, EMBASE, Cochrane Library, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, WANGFANG, Chinese Biomedical Literature Database, and China National Knowledge In-frastructure will be utilized to examine case-controlled studies that used TDS for detecting IS. All electronic databases will be searched from inception to March 20, 2020. Read More

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http://dx.doi.org/10.1097/MD.0000000000020451DOI Listing

Association between ALDH2 rs671 polymorphism and risk of ischemic stroke: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 May;99(21):e20206

Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China.

In last decades, many scholars have studied the relationship between aldehyde dehydrogenase 2 (ALDH2) rs671 and ischemic stroke (IS), however, the results obtained from these studies were inconclusive. The purpose of this study was to investigate the association between rs671 and the risk of IS by systematically review.Two researchers independently screened relevant published literatures, derived data and estimated the risk of bias of the research in Pubmed, Embase, Ovid, China National Knowledge Infrastructure (CNKI), Cochrane Library and China Biomedical Literature Database throughout March 29, 2020. Read More

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http://dx.doi.org/10.1097/MD.0000000000020206DOI Listing