73,930 results match your criteria Stroke Hemorrhagic


Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: Large Prospective cohort and preliminary meta-analysis.

Int J Stroke 2019 Feb 20:1747493019830065. Epub 2019 Feb 20.

1 Department of Neurology, Hemorrhagic Stroke Research Program, JPK Stroke Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Background: To obtain more precise estimates on cortical superficial siderosis as an MRI predictor of lobar intracerebral hemorrhage (ICH) recurrence risk in cerebral amyloid angiopathy (CAA) from a large prospective MRI cohort and a systematic review.

Methods: We analyzed a single-center MRI prospective cohort of consecutive CAA-related ICH survivors. Using Kaplan-Meier and Cox regression analyses, we investigated cortical superficial siderosis and ICH risk, adjusting for known confounders. Read More

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http://dx.doi.org/10.1177/1747493019830065DOI Listing
February 2019
3.833 Impact Factor

[Multiple ischemic stroke in Osler-Rendu-Weber disease].

Ideggyogy Sz 2019 Jan;72(1-2):65-70

Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ, Neurológiai Klinika, Szeged.

Hereditary hemorrhagic teleangiectasia (HHT, Osler-Rendu-Weber disease) is an autosomal dominantly inherited disorder caused by the mutation of several possible genes and characterized by malformations of the arteriovenous system in multiple organs. The clinical diagnosis is based on the Curaçao criteria ((1) spontaneous, recurrent epistaxis; (2) teleangiectasias in characteristic sites (lips, oral cavity, nose, fingers); (3) visceral lesions (gastrointestinal, pulmonary, cerebral, spinal); (4) affected first degree relative). The aim of this study is to present the first genetically confirmed Hungarian case of hereditary hemorrhagic teleangiectasia with multiple ischemic strokes. Read More

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http://dx.doi.org/10.18071/https://doi.org/10.18071/isz.72.0065DOI Listing
January 2019

Effects of cold temperature and snowfall on stroke mortality: A case-crossover analysis.

Environ Int 2019 Feb 20;126:89-95. Epub 2019 Feb 20.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Institut national de santé publique du Québec, Montreal, Quebec, Canada; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada. Electronic address:

Background: We sought to determine if cold temperature and snowfall are independently associated with stroke mortality, and whether effects differ between hemorrhagic and ischemic stroke.

Materials And Methods: We conducted a case-crossover study of 13,201 stroke deaths utilizing weather records between the months of November and April for Quebec, Canada from 1981 to 2015. We compared exposure to cold temperature and snowfall with controls days when stroke death did not occur. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.031DOI Listing
February 2019

High-Throughput Profiling of Circulating Antibody Signatures for Stroke Diagnosis Using Small Volumes of Whole Blood.

Neurotherapeutics 2019 Feb 19. Epub 2019 Feb 19.

Valtari Bio Incorporated, Morgantown, West Virginia, USA.

Accurate stroke recognition during triage can streamline care and afford patients earlier access to life-saving interventions. However, the tools currently available to clinicians for prehospital and early in-hospital identification of stroke are limited. The peripheral immune system is intricately involved in stroke pathology and thus may be targetable for the development of immunodiagnostics. Read More

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http://link.springer.com/10.1007/s13311-019-00720-9
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http://dx.doi.org/10.1007/s13311-019-00720-9DOI Listing
February 2019
4 Reads

Associations between statins and coronary artery disease and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome: A time-dependent regression study.

Atherosclerosis 2019 Feb 11;283:61-68. Epub 2019 Feb 11.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

Backgound And Aims: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).

Methods: We retrospectively enrolled patients with ACOS treated with (N = 916) and without (N = 6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.007DOI Listing
February 2019

Risk factors of intracranial hemorrhage after mechanical thrombectomy of anterior circulation ischemic stroke.

Neuroradiology 2019 Feb 18. Epub 2019 Feb 18.

Department of Neuroradiology, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Intracranial hemorrhage (ICH) is a potentially severe complication after mechanical thrombectomy (MT). Here, we investigated risk factors for the occurrence of any and symptomatic ICH after MT due to large-vessel occlusion of the anterior circulation.

Methods: Consecutive patients with acute ischemic anterior circulation stroke with large-vessel occlusion undergoing MT were analyzed. Read More

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http://dx.doi.org/10.1007/s00234-019-02180-6DOI Listing
February 2019

[Effectiveness of correction of post-stroke motor disorders using the methods of functional electrostimulation and BFB-stabilometric postural control].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):23-30

Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department, Moscow, Russia.

Aim: To evaluate the effectiveness of complex rehabilitation with the inclusion of functional electrostimulation (FES) and BFB-stabilometric postural control in patients with post-stroke motor disorders in the late recovery period.

Material And Methods: Sixty-seven patients in the late recovery period of stroke, 31 women and 36 men, mean age 58.4±6. Read More

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http://dx.doi.org/10.17116/jnevro201911901123DOI Listing
January 2019

Fatal inhalation of volcanic gases in three tourists of a geothermal area.

Forensic Sci Int 2019 Feb 7. Epub 2019 Feb 7.

Department of Experimental Medicine, Forensic Toxicology Unit, University of Campania "L. Vanvitelli", Via L. Armanni, 5, 80138, Naples, Italy.

The study reports the environmental, toxicological and histopathological forensic investigations applied on three victims of accidental death (father, mother and son), due to the fall in a volcanic pothole, during the touristic visit of the "Solfatara park", near Naples (Italy). At autopsy greenish skin discolouration was observed and all bodies showed the classical signs of asphyxial deaths, such as cyanosis and hemorrhagic pulmonary edema. Focal micro-hemorrhages were found in the brain at intracranial and subpial levels. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.01.044DOI Listing
February 2019

Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke.

Acta Neuropathol Commun 2019 Feb 18;7(1):23. Epub 2019 Feb 18.

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 240 W Green Street, Athens, GA, 30602, USA.

At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibits inflammatory cell extravasation in pathological conditions. Whether mural cell-derived laminin-α5 is involved in vascular integrity regulation, however, remains unknown. Read More

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http://dx.doi.org/10.1186/s40478-019-0676-8DOI Listing
February 2019

miR-195 Has a Potential to Treat Ischemic and Hemorrhagic Stroke through Neurovascular Protection and Neurogenesis.

Mol Ther Methods Clin Dev 2019 Jun 7;13:121-132. Epub 2019 Jan 7.

Department of Medical Research, China Medical University Hospital, 2 Yude Road, Taichung, 40447, Taiwan.

Tissue plasminogen activator is the only U.S. FDA-approved therapy for ischemic stroke, while there is no specific medication for hemorrhagic stroke. Read More

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http://dx.doi.org/10.1016/j.omtm.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365409PMC

Efficacy of Direct Revascularization Surgery for Hemorrhagic Moyamoya Syndrome As a Late Complication of Cranial Irradiation for Childhood Craniopharyngioma.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Tohoku University, Sendai, Japan.

Moyamoya syndrome (MMS) is an uncommon late complication after cranial irradiation. Its hemorrhagic presentation from the associated pseudo-aneurysm is extremely rare, and the optimal management strategy is undetermined. We herein report a 36-year-old man who developed intraventricular hemorrhage from a pseudo-aneurysm at the extended left anterior choroidal artery as an abnormal collateral of MMS 30 years after surgical removal and cranial irradiation for childhood craniopharyngioma. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.033DOI Listing
February 2019
1 Read

Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage.

Clin Chim Acta 2019 Feb 13;492:72-77. Epub 2019 Feb 13.

Department of Emergency Intensive Care Unit, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, 108 Wansong Road, Ruian 325200, Zhejiang Province, China.

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is currently known as an acute phase protein and implicated in acute brain injury. Herein, we sought to gauge serum NGAL level in patients after acute (<24 h) spontaneous intracerebral hemorrhage (ICH) and to investigate its relation to neurological outcome.

Methods: Serum NGAL levels were measured in 106 patients and 106 controls. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.009DOI Listing
February 2019

The Origin of Intracranial Pressure Causing Brainstem Hemorrhages.

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Division of Neurocritical Care and Hospital Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

The origin of secondary brainstem hemorrhages following an acute expansive hemispheric lesion has been attributed to Henri Duret, who proposed that hemorrhaging was caused by a shock wave through the cerebral spinal fluid. However, other experiments have shown important findings correlating brainstem hemorrhages to arterial hemorrhages. Animal studies found that the rapidity of expansion of a lesion would be crucial in producing these lesions, but there was no consistent correlation with paratentorial grooving so commonly seen with increased intracranial pressure. Read More

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http://dx.doi.org/10.1007/s12028-019-00688-6DOI Listing
February 2019
1 Read

Predictors and Clinical Impact of Delayed Stent Thrombosis after Thrombectomy for Acute Stroke with Tandem Lesions.

AJNR Am J Neuroradiol 2019 Feb 14. Epub 2019 Feb 14.

From the Interventional Neuroradiology Department (R.P., D.M., M.M., J.S.R., R.B.).

Background And Purpose: There are very few published data on the patency of carotid stents implanted during thrombectomies for tandem lesions in the anterior circulation. We aimed to communicate our experience of stenting in the acute setting with systematic follow-up of stent patency and discuss predictors and clinical repercussions of delayed stent thrombosis.

Materials And Methods: We performed a retrospective study of stroke thrombectomies in a single center between January 2009 and April 2018. Read More

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http://dx.doi.org/10.3174/ajnr.A5976DOI Listing
February 2019

Twenty-and-a-half syndrome: a case report.

J Med Case Rep 2019 Feb 15;13(1):35. Epub 2019 Feb 15.

Department of Neurology, Sri Aurobindo Medical College & P.G. Institute, 4th Floor, Sanwer Road, Indore, MP, 453555, India.

Background: In the list of named numerical neuro-ophthalmological syndromes, such as one-and-a-half syndrome and others, we report for the first time twenty-and-a-half syndrome, which is characterized by one-and-a-half syndrome with bilateral seventh and right fifth nerve palsy (1.5 + 7 + 7 + 5 = 20.5) in a patient with ischemic stroke. Read More

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http://dx.doi.org/10.1186/s13256-019-1980-4DOI Listing
February 2019
1 Read

Sequential Monitoring of the Comparative Effectiveness and Safety of Dabigatran in Routine Care.

Circ Cardiovasc Qual Outcomes 2019 Feb;12(2):e005173

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (S.S., C.G., J.M.F., M.K., K.F.H.).

Background The increasing availability of electronic healthcare data enables ongoing monitoring of the effectiveness and safety of newly marketed medications. We sought to demonstrate a 5-year prospective monitoring system of dabigatran for stroke prevention that may expedite discovery and allow ongoing evidence development. Methods and Results Between 2011 and 2015, we conducted 9 sequential analyses of dabigatran versus warfarin users in a sequential cohort design in 2 US claims databases. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005173DOI Listing
February 2019
1 Read

Reversal and Resumption of Antithrombotic Therapy in LVAD- Associated Intracranial Hemorrhage.

Ann Thorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio; Department of Neurology, NYU School of Medicine, New York, NY. Electronic address:

Background: Little data exists regarding reversal and resumption of antithrombotics following left ventricular assist device (LVAD)-associated intracranial hemorrhage (ICH).

Methods: Prospectively collected data of LVAD patients with ICH was reviewed. Coagulopathy reversal agents, antithrombotic regimens and thrombotic (venous thromboembolism, ischemic stroke, myocardial infarction) and hemorrhagic (recurrent ICH, gastrointestinal bleed, anemia requiring transfusion) complications were recorded. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.016DOI Listing
February 2019
1 Read

Management of oral anticoagulation after intracerebral hemorrhage.

Int J Stroke 2019 Feb 14:1747493019828555. Epub 2019 Feb 14.

Department of Neurology, University Hospital Erlangen, Erlangen, Germany.

Background: The most recent years have significantly expanded knowledge regarding risks and benefits of resuming oral anticoagulation (OAC) after intracerebral hemorrhage (ICH). No randomized data is yet available, though several large observational studies and meta-analyses have investigated the impact of resuming OAC on thromboembolic versus hemorrhagic complications in these high-risk patients after ICH.

Aims: The present review will summarize the most important studies conducted over the last years and will focus on relevant factors help guiding on decision-making on whether to start OAC after ICH. Read More

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http://dx.doi.org/10.1177/1747493019828555DOI Listing
February 2019

Incidence of post-stroke depression in Parakou in 2014.

Geriatr Psychol Neuropsychiatr Vieil 2019 Feb 12. Epub 2019 Feb 12.

Unité d'enseignement et de recherche de neurologie, FSS Université d'Abomey-Calavi, Bénin.

Depression is a frequent psychiatric complication after a stroke. In a Sub-Saharan Africa, the majority of the studies are about their prevalence, but the incidence of post-stroke depression was rarely estimated. We aimed to estimate this incidence in Parakou, Benin. Read More

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http://dx.doi.org/10.1684/pnv.2018.0777DOI Listing
February 2019

Blood pressure variability and hemorrhagic transformation in patients with successful recanalization after endovascular recanalization therapy: a retrospective observational study.

Ann Neurol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.

Objective: Although BP variability has been regarded as a risk factor for hemorrhagic transformation (HTF) after intravenous thrombolysis, its effect on HTF after endovascular recanalization therapy (ERT) remains to be elucidated. We aimed to study the relationship between BP variability and symptomatic intracerebral hemorrhage (sICH) after successful recanalization with ERT.

Methods: A total of 211 patients with acute ischemic stroke and successful recanalization (Thrombolysis in Cerebral Infarction 2b or 3) after ERT were included between January 2013 and May 2017. Read More

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http://dx.doi.org/10.1002/ana.25434DOI Listing
February 2019
1 Read

Stroke Severity Versus Dysphagia Screen as Driver for Post-stroke Pneumonia.

Front Neurol 2019 29;10:16. Epub 2019 Jan 29.

Stroke and Ageing Research (STARC), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Post-stroke pneumonia is a feared complication of stroke as it is associated with greater mortality and disability than in those without pneumonia. Patients are often kept "Nil By Mouth" (NBM) after stroke until after receiving a screen for dysphagia and declared safe to resume oral intake. We aimed to assess the proportional contribution of stroke severity and dysphagia screen to pneumonia by borrowing idea from coalition game theory on fair distribution of marginal profit (Shapley value). Read More

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http://dx.doi.org/10.3389/fneur.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361825PMC
January 2019
1 Read

Evaluation of vestibular and oculomotor functions in individuals with dizziness after stroke.

Arq Neuropsiquiatr 2019 Jan;77(1):25-32

Universidade Federal de Santa Maria, Departamento de Fonoaudiologia, Santa Maria, RS, Brasil.

Objective: Changes in postural balance and visual complaints are frequent consequences of stroke. We aimed to investigate the symptoms and the vestibular and oculomotor functions of patients with dizziness post ischemic and hemorrhagic stroke and compare the results among them.

Methods: Fifty patients with dizziness after stroke were evaluated through a clinical anamnesis and computerized vector electronystagmography: calibration of ocular movements, spontaneous nystagmus, semi-spontaneous nystagmus, pendular tracking, optokinetic nystagmus, rotary chair testing, and the caloric test. Read More

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http://dx.doi.org/10.1590/0004-282X20180154DOI Listing
January 2019
1 Read

[Atrial fibrillation in severe and end stage renal disease: from oral anticoagulation therapy to percutaneous left atrial appendage occlusion].

G Ital Nefrol 2019 Feb;36(1)

Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Non-valvular atrial fibrillation (AF) is the most frequent arrhythmia in the general population and its prevalence increases with age. The prevalence and incidence of AF is high in patients with chronic kidney failure (CKD). The most important complication associated with AF, both in the general population and in that with CKD, is thromboembolic stroke. Read More

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February 2019
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Mixed cerebrovascular disease in an elderly patient with mixed vascular risk factors: a case report.

BMC Neurol 2019 Feb 12;19(1):26. Epub 2019 Feb 12.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.

Background: Mixed cerebrovascular disease is a diagnostic entity that presents with hemorrhagic and ischemic stroke clinically and/or subclinically. Here, we report a patient with mixed vascular risk factors, who presented with multiple intracerebral hemorrhages and a simultaneously occurring cerebral infarction with hemorrhagic transformation.

Case Presentation: A 63-year-old male with no history of trauma or prior neurological disease presented with a sudden onset of weakness in his right limbs, followed by an episode of focal seizure without impaired awareness. Read More

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http://dx.doi.org/10.1186/s12883-019-1248-zDOI Listing
February 2019
2 Reads

Anticoagulation risk assessment for patients with non-valvular atrial fibrillation and venous thromboembolism: A clinical review.

Vasc Med 2019 Feb 12:1358863X18819816. Epub 2019 Feb 12.

1 Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD, USA.

Non-valvular atrial fibrillation and venous thromboembolism anticoagulation risk assessment tools have been increasingly utilized to guide implementation and duration of anticoagulant therapy. Anticoagulation significantly reduces stroke and recurrent venous thromboembolism risk, but comes at the cost of increased risk of major and clinically relevant non-major bleeding. The decision for anticoagulation in high-risk patients is complicated by the fact that many risk factors associated with increased thromboembolic risk are simultaneously associated with increased bleeding risk. Read More

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http://dx.doi.org/10.1177/1358863X18819816DOI Listing
February 2019
1 Read

Cerebral microbleeds: Beyond the macroscope.

Int J Stroke 2019 Feb 12:1747493019830594. Epub 2019 Feb 12.

1 Department of Medical Pharmacology, Univ Lille, Inserm U1171-Degenerative and Vascular Cognitive Disorders, CHU Lille, Lille, France.

While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling finding for physicians. These small dot-like lesions are thought to be old perivascular collections of hemosiderin deposits. They can be found in different neurological settings such as cerebrovascular or neurodegenerative diseases. Read More

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http://dx.doi.org/10.1177/1747493019830594DOI Listing
February 2019
1 Read

Spontaneous Intracranial and Lumbar Subdural Hematoma Presenting as Vaginal Pain.

J Emerg Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Spontaneous spinal and intracranial subdural hematomas are rarely reported, especially occurring simultaneously. Anticoagulation use has been associated with spontaneous hemorrhages. Prompt diagnosis is required to prevent permanent neurological sequelae. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.12.032DOI Listing
February 2019
2 Reads

Association Between Heart Transplantation and Subsequent Risk of Stroke Among Patients With Heart Failure.

Stroke 2019 Feb 12:STROKEAHA118023622. Epub 2019 Feb 12.

From the Clinical and Translational Neuroscience Unit (A.E.M., M.L.C., N.S.P., S.B.M., B.B.N., C.I., H.K.).

Background and Purpose- It is uncertain whether heart transplantation decreases the risk of stroke. The objective of our study was to determine whether heart transplantation is associated with a decreased risk of subsequent stroke among patients with heart failure awaiting transplantation. Methods- We performed a retrospective cohort study using administrative data from New York, California, and Florida between 2005 and 2015. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023622DOI Listing
February 2019
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Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis.

Cell Transplant 2019 Feb 11:963689719829073. Epub 2019 Feb 11.

1 Department of Neurosurgery, Comprehensive Surgical Laboratory, Affiliated Hospital of Nantong University, P.R. China.

Neuronal apoptosis is regarded as one of the most important pathophysiological changes of intracerebral hemorrhagic (ICH) stroke-a major public health problem that leads to high mortality rates and functional dependency. Mitogen-and stress-activated kinase (MSK) 1 is implicated in various biological functions in different cell types, including proliferation, tumorigenesis and responses to stress. Our previous study showed that MSK1 phosphorylation (p-MSK1) is related to the regulation of LPS-induced astrocytic inflammation, and possibly acts as a negative regulator of inflammation. Read More

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http://dx.doi.org/10.1177/0963689719829073DOI Listing
February 2019

Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model.

Circulation 2019 Feb 12. Epub 2019 Feb 12.

Molecular Biology, Tulane University, New Orleans, LA.

Background: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder caused by heterozygous, loss-of-function mutations in four TGFβ pathway members, including the central transcriptional mediator of the TGFβ pathway, Smad4. Loss of Smad4 causes the formation of inappropriate, fragile connections between arteries and veins called arteriovenous malformations (AVM), which can hemorrhage leading to stroke, aneurysm or death. Unfortunately, the molecular mechanisms underlying AVM pathogenesis remain poorly understood and the TGFβ downstream effectors responsible for HHT-associated AVM formation are currently unknown. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036952DOI Listing
February 2019

Neurological Complications of Cardiological Interventions.

Curr Neurol Neurosci Rep 2019 Feb 9;19(2). Epub 2019 Feb 9.

Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins drive, Iowa City, IA, 52242, USA.

Purpose Of Review: Neurological complications are common during cardiac procedures. The type of procedure influences the profile of neurological complications and their management. In this article, we review the different neurological complications encountered following cardiac procedures, and treatment strategies for managing those complications. Read More

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http://link.springer.com/10.1007/s11910-019-0923-1
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http://dx.doi.org/10.1007/s11910-019-0923-1DOI Listing
February 2019
8 Reads

Effect of choroidal collateral vessels on de novo hemorrhage in moyamoya disease: analysis of nonhemorrhagic hemispheres in the Japan Adult Moyamoya Trial.

J Neurosurg 2019 Feb 8:1-7. Epub 2019 Feb 8.

1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto.

OBJECTIVEFollowing hemorrhagic stroke in moyamoya disease, de novo intracranial hemorrhage can occur in the previously unaffected nonhemorrhagic hemisphere. In the present analysis the authors intended to determine whether the presence in the nonhemorrhagic hemisphere of choroidal collateral vessels, which have been the focus of attention as a source of bleeding, affects the risk of de novo hemorrhage.METHODSThe subject of focus of the present cohort study was the nonhemorrhagic hemispheres of adult patients with hemorrhagic moyamoya disease enrolled in the Japan Adult Moyamoya Trial and allocated to the nonsurgical arm. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181139DOI Listing
February 2019
1 Read

Analysis of the Factors Related to the Effectiveness of Transcranial Current Stimulation in Upper Limb Motor Function Recovery after Stroke: a Systematic Review.

J Med Syst 2019 Feb 8;43(3):69. Epub 2019 Feb 8.

Departament of Surgery, University of Salamanca, Alfonso X el Sabio s/n, 37007, Salamanca, Spain.

Transcranial direct current stimulation is one of the non-invasive techniques whose main mechanism of action is based on its modulation of cortical excitability. The objective of this study is to analyze the variables (i.e, demographics, clinicals, stimulation parameters) that could influence into the responses during rehabilitation of the upper extremity in patients with stroke. Read More

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http://dx.doi.org/10.1007/s10916-019-1193-9DOI Listing
February 2019
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Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.

J Neurol Sci 2019 Feb 1;399:3-5. Epub 2019 Feb 1.

Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.01.051DOI Listing
February 2019

Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.

Stroke 2018 Dec;49(12):3081-3084

From the Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Switzerland (M.N.S., E.K., O.B., L.R.)

Background and Purpose—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022808DOI Listing
December 2018
1 Read
5.723 Impact Factor

Cerebral pontine infarctions during pregnancy - A case report and review of the literature.

Case Rep Womens Health 2019 Jan 23;21:e00097. Epub 2019 Jan 23.

University of South Alabama, Children's and Women's Hospital, Department of Obstetrics and Gynecology, 251 Cox Street, Mobile, AL 36604, United States.

Cerebrovascular disease is not uncommon during pregnancy as a result of either venous or arterial occlusion, or a hemorrhagic event, resulting in ischemia. Pregnancy may alter the prognosis of these neurologic disorders, with increased risks of morbidity and mortality for the mother and the developing fetus. Etiologies of stroke during pregnancy and the postpartum period include preeclampsia, eclampsia, HELLP syndrome, posterior reversible encephalopathy syndrome (PRES), amniotic fluid embolism, postpartum angiopathy, postpartum cardiomyopathy, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), cerebral venous thrombosis, CNS infections, and maternal thrombophilia. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358547PMC
January 2019
2 Reads

Association of Elevated Blood Pressure Levels with Outcomes in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A Systematic Review and Meta-Analysis.

J Stroke 2019 Jan 31;21(1):78-90. Epub 2019 Jan 31.

Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background And Purpose: Although arbitrary blood pressure (BP) thresholds exist for acute ischemic stroke (AIS) patients eligible for intravenous thrombolysis (IVT), current international recommendations lack clarity on the impact of mean pre- and post-IVT BP levels on clinical outcomes.

Methods: Eligible studies involving IVT-treated AIS patients were identified that reported the association of mean systolic BP (SBP) or diastolic BP levels before and after IVT with the following outcomes: 3-month favorable functional outcome (modified Rankin Scale [mRS] scores of 0-1) and 3-month functional independence (mRS scores of 0-2), 3-month mortality and symptomatic intracranial hemorrhage (sICH). Unadjusted analyses of standardized mean differences and adjusted analyses of studies reporting odds ratios (ORadj) per 10 mm Hg BP increment were performed using random-effects models. Read More

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http://dx.doi.org/10.5853/jos.2018.02369DOI Listing
January 2019
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Treatment of Hemichoreoathetosis with Arrhythmic Proximal Tremor after Stroke: The Role of Zona Incerta as a Target for Deep Brain Stimulation.

J Mov Disord 2019 Jan 30;12(1):47-51. Epub 2019 Jan 30.

Department of Neurosurgery, University of Joinville Region, and Neurological and Neurosurgical Clinic of Joinville, Joinville.

Deep brain stimulation (DBS) of the zona incerta has shown promising results in the reduction of medically refractory movement disorders. However, evidence supporting its efficacy in movement disorders secondary to hemorrhagic stroke or hemichoreoathetosis is limited. We describe a 48-year-old man who developed progressive hemichoreoathetosis with an arrhythmic, proximal tremor in his right arm following a thalamic hemorrhagic stroke. Read More

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http://dx.doi.org/10.14802/jmd.18032DOI Listing
January 2019
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The Barcelona-Asymptomatic Intracranial Atherosclerosis study: Subclinical intracranial atherosclerosis as predictor of long-term vascular events.

Atherosclerosis 2019 Jan 29;282:132-136. Epub 2019 Jan 29.

Servicio de Neurología, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain. Electronic address:

Background And Aims: Symptomatic intracranial atherosclerosis (ICAS) is associated with a high risk of stroke recurrence and occurrence of other vascular events. However, ICAS has been poorly studied from its asymptomatic stage. The objective of our study was to determine if subclinical intracranial atherosclerosis is associated with long-term incident vascular events in Caucasians. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.022DOI Listing
January 2019
6 Reads

Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo F-Magnetic Resonance Spectroscopic Imaging.

Contrast Media Mol Imaging 2019 6;2019:8908943. Epub 2019 Jan 6.

Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.

Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new F-molecular ligand, TGF-019, for visualizing the distribution of MMPs in vivo using F-magnetic resonance spectroscopic imaging (F-MRSI). Read More

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http://dx.doi.org/10.1155/2019/8908943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339703PMC
January 2019
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[Immediate outcomes of microsurgical treatment of cerebral arteriovenous malformations in non-hemorrhagic patients].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):30-37

Burdenko Neurosurgical Institute, Moscow, Russia.

Arteriovenous malformations (AVMs) are some of the most frequent congenital abnormalities of the cerebral vascular system and usually occur at a young age. Given the fact that AVMs can manifest, in addition to hemorrhages, as symptomatic epilepsy (17-40%) that occurs more often at a young age and may lead to significant disability, investigation of this pathology remains topical. Particular attention has recently been paid to the management of AVM patients without clinical signs of hemorrhage at the time of pathology diagnosis. Read More

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http://dx.doi.org/10.17116/neiro20188206130DOI Listing
January 2018

Prevalence of Atrial Fibrillation and use of Oral Antithrombotic Therapy in Patients with Acute Coronary Syndrome.

Kardiologiia 2019 Jan 27;59(1):40-48. Epub 2019 Jan 27.

Sechenov First Moscow State Medical University (Sechenov University).

Purpose: To assess the prevalence of atrial fibrillation (AF) and use of antithrombotic agents in adult patients with acute coronary syndrome (ACS).

Materials And Methods: We consecutively enrolled all ACS patients (n=1155) who were hospitalized in two Moscowbased percutaneous coronary intervention centers (each center performs over 500 PCIs a year) between October 2017 and February 2018. AF was diagnosed in 204 patients (17. Read More

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https://lib.ossn.ru/jour/article/view/429
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http://dx.doi.org/10.18087/cardio.2019.1.10213DOI Listing
January 2019
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Neurologic Deficit Following Aortic Arch Replacement: The Influence of the Aortic Atherosclerosis.

Ann Thorac Surg 2019 Jan 30. Epub 2019 Jan 30.

Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550 Japan.

Background: Postoperative neurologic deficits are associated with significant morbidity in aortic arch replacement.

Methods: A group of 198 consecutive patients undergoing isolated total aortic arch replacement using antegrade cerebral perfusion were analyzed for the risk factors of neurologic deficit. Using computed tomography, atherothrombotic lesions (defined as extensive intimal thickening exceeding 4 mm) were identified in the proximal aorta (the ascending aorta or aortic arch) in 26. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193012
Publisher Site
http://dx.doi.org/10.1016/j.athoracsur.2019.01.004DOI Listing
January 2019
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Impact of Collateral Filling Delay on the Development of Subacute Complications After Acute Ischemic Stroke.

Clin Neuroradiol 2019 Feb 1. Epub 2019 Feb 1.

Department of Radiology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: Leptomeningeal collaterals play a pivotal role in acute ischemic stroke. While most collateral scores rely on subjective visual analysis, an objective quantification is possible using dynamic computed tomography (CT) angiography (dynCTA). The aim was to determine the value of collateral filling delay (CFD) as assessed by dynCTA for predicting subacute stroke complications. Read More

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http://dx.doi.org/10.1007/s00062-019-00760-wDOI Listing
February 2019
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Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study.

Sci Rep 2019 Jan 31;9(1):1043. Epub 2019 Jan 31.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

There has been limited data discussing the relationship between apparent treatment-resistant hypertension (ATRH) and cardiovascular disease risk in patients receiving maintenance hemodialysis. We analyzed data for 2999 hypertensive patients on maintenance hemodialysis. ATRH was defined as uncontrolled blood pressure despite the use of three or more classes of antihypertensive medications, or four or more classes of antihypertensive medications regardless of blood pressure level. Read More

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http://dx.doi.org/10.1038/s41598-018-37961-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355838PMC
January 2019
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Hyperperfusion after Endovascular Reperfusion Therapy for Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Background And Purpose: Patients with acute ischemic stroke (AIS) may display prolonged neurological deficits and conscious disturbance even after successful endovascular thrombectomy. We hypothesized that hemodynamic change after reperfusion might influence outcomes. This study investigated the factors causing hyperperfusion and outcomes. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.007DOI Listing
January 2019
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Timing of Anticoagulation in Atrial Fibrillation Status Post Cardioembolic Stroke.

J Pharm Pract 2019 Jan 31:897190019825577. Epub 2019 Jan 31.

2 Pharmacy Practice Department, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA.

Background:: Anticoagulation is the mainstay of secondary stroke prevention in patients with atrial fibrillation; however, few studies have assessed the optimal timing for initiation of anticoagulation post cardioembolic stroke. In the 2 weeks following an acute cardioembolic stroke, the risk of recurrent stroke is as high as 8%, but this risk must be balanced against the risk of hemorrhagic transformation with early initiation of anticoagulation.

Purpose:: This study described the time to initiation of anticoagulation and evaluated the in-hospital incidence of hemorrhagic and ischemic complications in 106 patients with atrial fibrillation post an acute cardioembolic stroke. Read More

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http://dx.doi.org/10.1177/0897190019825577DOI Listing
January 2019
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Association between urban green space and the risk of cardiovascular disease: A longitudinal study in seven Korean metropolitan areas.

Environ Int 2019 Apr 28;125:51-57. Epub 2019 Jan 28.

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Purpose: Few previous studies have investigated the association between urban green space and cardiovascular disease (CVD) within Asian populations. We aimed to determine the relationship between amount of green space in the residential environment and CVD within a large general Asian population in this population-based longitudinal study.

Methods: The study population consisted of 351,409 participants aged over 20 years extracted from the National Health Insurance Service National Sample Cohort. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.038DOI Listing

Determinants of quality of life in patients with hemorrhagic stroke: A path analysis.

Authors:
Wei Zhu Yan Jiang

Medicine (Baltimore) 2019 Feb;98(5):e13928

West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.

Identifying the determinants of health-related quality of life (HRQOL) improved assessment and decision-making in clinical practice. A few studies have focused on the determinants of HRQOL and their interrelationships in patients with hemorrhagic stroke. The aim of this study was to identify the factors contributing to HRQOL and exam their interrelationships. Read More

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http://dx.doi.org/10.1097/MD.0000000000013928DOI Listing
February 2019

Chronic obstructive pulmonary disease and cerebrovascular diseases: functional and clinical aspect of comorbidity.

Ter Arkh 2018 Apr;90(3):81-88

Far Eastern federal university, Vladivostok, Russia.

Literature data of chronic obstructive pulmonary disease (COPD) and cerebrovascular diseases (CVD) comorbidity are represented in this review. Key aspects of this interaction and its importance for clinical medicine have been considered. CVD and COPD are the main mortality factors in adults, which contribute to great economic wastes. Read More

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http://dx.doi.org/10.26442/terarkh201890381-88DOI Listing
April 2018
1 Read