73,468 results match your criteria Stroke Hemorrhagic


Moyamoya angiopathy: long-term follow-up study in a Finnish population.

J Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology and Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background And Purpose: Moyamoya angiopathy (MMA) is a chronic cerebrovascular disorder predominantly starting in childhood or early adulthood and thus affects the whole lifetime. Little is known on MMAs long-term outcomes in European patients. We report long-term follow-up data on Finnish MMA patients. Read More

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http://dx.doi.org/10.1007/s00415-018-9154-7DOI Listing
December 2018

Treatment of bleeding complications in patients on anticoagulant therapy.

Blood 2018 Dec 17. Epub 2018 Dec 17.

Department of Medicine, Division of Hematology and Thromboembolism, and Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada

Anticoagulant therapy is often refrained from due to the fear of hemorrhagic complications. The most frequent type of major bleeding is gastrointestinal but intracranial hemorrhage has the worst prognosis. Management of these complications in patients on anticoagulants should follow the same routines as for non-anticoagulated patients, as described here with the above-mentioned bleeds as examples. Read More

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http://dx.doi.org/10.1182/blood-2018-06-820746DOI Listing
December 2018

Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage.

J Stroke 2018 Dec 18. Epub 2018 Dec 18.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background And Purpose: As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH).

Methods: We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers. Read More

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http://dx.doi.org/10.5853/jos.2018.02033DOI Listing
December 2018

Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society.

J Stroke 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Despite the great socioeconomic burden of stroke, there have been few reports of stroke statistics in Korea. In this scenario, the Epidemiologic Research Council of the Korean Stroke Society launched the "Stroke Statistics in Korea" project, aimed at writing a contemporary, comprehensive, and representative report on stroke epidemiology in Korea. This report contains general statistics of stroke, prevalence of behavioral and vascular risk factors, stroke characteristics, pre-hospital system of care, hospital management, quality of stroke care, and outcomes. Read More

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http://dx.doi.org/10.5853/jos.2018.03125DOI Listing
December 2018

Management of Cerebral Microbleeds in Clinical Practice.

Transl Stroke Res 2018 Dec 15. Epub 2018 Dec 15.

Stroke Program, Department of Medicine, University of Alberta, Edmonton, T6G 2G3, Canada.

Cerebral microbleeds (CMBs) are very frequent diagnoses with MRI imaging in the elderly or in patients with cerebral infarction, intracranial hemorrhage (ICH), and dementia. The mechanisms for CMBs are not fully understood but may be secondary to injury to the vascular wall from long-standing hypertension or amyloid deposition in the tissue. The presence of CMB increases the risk for stroke, dementia, and death. Read More

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http://link.springer.com/10.1007/s12975-018-0678-z
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http://dx.doi.org/10.1007/s12975-018-0678-zDOI Listing
December 2018
2 Reads

A Case of Multiple Cerebral Infarction Preceding Acute Exacerbation of Idiopathic Thrombocytopenic Purpura.

J Stroke Cerebrovasc Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan.

Background: Although it was suggested that idiopathic thromobocytopenic purpura (ITP) can be a paradoxical cause of cerebral infarction, previous reports indicate that cerebral infarction associated with ITP occurs when thrombocytopenia is already evident at the onset of cerebral infarction.

Case Report: We report a case of multiple cerebral infarction that preceded acute exacerbation of ITP. An 80-year-old woman with a history of ITP presented with tetraplegia, and brain magnetic resonance imaging revealed multiple infarction in bilateral cerebral and cerebellar hemispheres. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.026DOI Listing
December 2018

Safety and efficacy of cangrelor in acute stenting for the treatment of cerebrovascular pathology: preliminary experience in a single-center pilot study.

J Neurointerv Surg 2018 Dec 14. Epub 2018 Dec 14.

Lyerly Neurosurgery, Baptist Neurological Institute, Baptist Health, Jacksonville, Florida, USA.

Background: Treatment of acute cerebrovascular pathology, such as acute ischemic stroke or intracranial aneurysms, presents a challenge if an extracranial or intracranial stent is required; immediate platelet inhibition is vital. To date, there is no standardized approach for antiplatelet inhibition in an acute setting.

Objective: To report our preliminary experience and lessons learnt using cangrelor in acute neurointervention. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014396DOI Listing
December 2018

Hemofiltration for neuroprotection in acute ischemic stroke: a prospective, pilot study.

Acta Neurol Scand 2018 Dec 13. Epub 2018 Dec 13.

National Research Oncology and Transplantation Center, Astana, Kazakhstan.

Background: Hemofiltration reduces blood levels of cytokines, glutamate and other substances that increase the risk of stroke-associated neurodegeneration. This study aimed to assess the safety and efficacy of hemofiltration in acute ischemic stroke patients.

Methods: 37 patients (mean age 56±16 years) who had an ischemic stroke within the previous 12 hours were randomized to receive hemofiltration for 36 hours (n=19) or standard treatment (n=18). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13060
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http://dx.doi.org/10.1111/ane.13060DOI Listing
December 2018
1 Read

Single-center experience using the 3MAX or 4MAX reperfusion catheter for the treatment of acute ischemic stroke with distal arterial occlusions in patients not eligible for intravenous fibrinolysis.

Radiol Med 2018 Dec 13. Epub 2018 Dec 13.

Unit of Neuroimaging and Neurointervention (NINT), Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Universitaria Senese, Policlinico "Santa Maria alle Scotte", Viale M. Bracci 2, Siena, Italy.

Background: In acute stroke, distal cerebrovascular occlusions can be linked to severe clinical symptoms, and treatment by mechanical thrombectomy may have an important clinical impact. When intravenous fibrinolytic therapy is firmly contraindicated, it remains the only treatment option.

Methods: A total of 42 patients with isolated distal arterial occlusions and absolute contraindication for intravenous fibrinolytic therapy were retrospectively included. Read More

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http://dx.doi.org/10.1007/s11547-018-0965-5DOI Listing
December 2018

Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys.

Pharmacol Res Perspect 2018 12 5;6(6):e00448. Epub 2018 Dec 5.

Department of Applied Biological Science Tokyo Noko University (Tokyo University of Agriculture and Technology) Tokyo Japan.

SMTP-7 ( triprenyl phenol-7) is a small molecule that promotes thrombolysis and suppresses inflammation possibly through plasminogen modulation and soluble epoxide hydrolase (sEH) inhibition, respectively. Here, we demonstrate an efficacy of SMTP-7 in a severe embolic stroke model in monkeys. The middle cerebral artery was embolized by an autologous blood clot. Read More

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http://dx.doi.org/10.1002/prp2.448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282002PMC
December 2018

Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention.

Circ Cardiovasc Interv 2018 Dec;11(12):e006761

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (S.S., S.K., M.S., Y.S., K.H., S.Y., K.F.).

Background: Periprocedural stroke is a rare but life-threatening complication of percutaneous coronary intervention (PCI). Transradial intervention (TRI) is more beneficial than transfemoral intervention for periprocedural bleeding and acute kidney injuries, but its effect on periprocedural stroke has not been fully investigated. Our study aimed to assess risk predictors of periprocedural stroke according to PCI access site. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006761DOI Listing
December 2018
1 Read

Collagen COL22A1 maintains vascular stability and mutations in are potentially associated with intracranial aneurysms.

Dis Model Mech 2018 Dec 12;11(12). Epub 2018 Dec 12.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA

Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing approach to generate a loss-of-function mutant in zebrafish Homozygous mutant adults exhibit increased incidence of intracranial hemorrhages, which become more prominent with age and after cardiovascular stress. Read More

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http://dx.doi.org/10.1242/dmm.033654DOI Listing
December 2018

Brain tissue iron quantification by MRI in intracerebral hemorrhage: Current translational evidence and pitfalls.

J Cereb Blood Flow Metab 2018 Dec 12:271678X18818911. Epub 2018 Dec 12.

2 Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.

Intracerebral hemorrhage (ICH) is a common subtype of hemorrhagic stroke with devastating consequences with no specific treatment. There is, however, substantial evidence for iron-mediated neurotoxicity in animal ICH models. Non-invasive quantification of the peri-hematomal tissue iron based on MRI has shown some promise in animal models and is being validated for clinical translation. Read More

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http://dx.doi.org/10.1177/0271678X18818911DOI Listing
December 2018

Hemorrhagic Transformation After Acute Ischemic Stroke in Atrial Fibrillation Patients.

J Stroke Cerebrovasc Dis 2019 Jan 26;28(1):234. Epub 2018 Oct 26.

Department of Radiology, Mayo Clinic, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.047DOI Listing
January 2019
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Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.

Sci Rep 2018 Dec 11;8(1):17770. Epub 2018 Dec 11.

Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.

Although the regulation of post-ischemic inflammation is an important strategy to treat ischemic stroke, all clinical trials have failed to show its efficacy. To solve the problem, we previously developed a novel partial peptide of RANKL, microglial healing peptide 1 (MHP1), which could reduce ischemic injury by inhibiting Toll-like receptor (TLR) induced inflammation. However, optimization of the peptide was necessary to increase the stability and efficacies for clinical use. Read More

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http://dx.doi.org/10.1038/s41598-018-35898-zDOI Listing
December 2018

First attempt recanalization with ADAPT: rate, predictors, and outcome.

J Neurointerv Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Introduction: The rate of first-attempt recanalization (FAR) with the newer-generation thrombectomy devices, and more specifically with aspiration devices, is not well known. Moreover, the effect of FAR on outcomes after mechanical thrombectomy is not properly understood.

Objective: To report the rate of FAR using a direct aspiration first pass technique (ADAPT), investigate the association between FAR and outcomes, and identify the predictors of FAR. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014294DOI Listing
December 2018

Cortical surface intracranial electrodes identify clinically relevant seizures missed on scalp EEG after traumatic intracranial hemorrhage.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Seizures and other electrophysiological disturbances are an under-recognized cause of coma, focal deficits, and prolonged encephalopathy following subdural hematoma evacuation. In these patients, it is possible that seizures remain unrecognized on scalp EEG. It has been shown that a high burden of seizures and other electrophysiological disturbances exist following surgical evacuation and underlie the encephalopathy commonly seen in this patient population, predisposing them to medical complications and confounding estimates of prognosis. Read More

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http://dx.doi.org/10.1684/epd.2018.1015DOI Listing
December 2018

Intra-Arterial tPA is a Safe Rescue Therapy with Mechanical Thrombectomy.

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Medical University of South Carolina Charleston, SC, USA.

Introduction: Intra-arterial tissue plasminogen activator (IA-tPA) has been widely used in conjunction with mechanical thrombectomy (MT) or as rescue therapy. Data on the safety of IA tPA as a rescue therapy is scarce.

Objective: To report the safety outcome of IA tPA during mechanical thrombectomy with respect to hemorrhage. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.232DOI Listing
December 2018

Subacute Elevation of Plasma Level of Caspase-Cleaved Cytokeratin-18 is Associated with Hemorrhagic Transformation and Functional Outcome in Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurology, University of Pecs, Pecs, Hungary. Electronic address:

Background: Caspase-cleaved cytokeratin-18 (CCCK-18) is an apoptosis marker. Here, we analyzed the relationship between plasma level of CCCK-18 in the acute and subacute stage of ischemic stroke and early and late functional outcome. Besides, correlation among CCCK-18 and complications, such as hemorrhagic transformation (HT) were also explored. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.015DOI Listing
December 2018

Use of Anti-coagulation Agents after Traumatic Intracranial Hemorrhage.

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center at Houston, Texas USA. Electronic address:

Objectives: Anticoagulant therapy (ACT) after traumatic intracranial hemorrhage may lead to progression of hemorrhage, but in the presence of thromboembolic events the clinician must decide if the benefits outweigh the risks. Currently, no data exist to guide therapy in the acute setting.

Patients And Methods: We retrospectively identified all patients admitted to our institution with traumatic intracranial hemorrhage that received intravenous heparin, full dose enoxaparin, or warfarin during their initial hospitalization over a three-year period. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.173DOI Listing
December 2018

Intravenous Thrombolysis After Idarucizumab Application in Acute Stroke Patients-A Potentially Increased Sensitivity of Thrombi to Lysis?

J Stroke Cerebrovasc Dis 2018 Dec 6. Epub 2018 Dec 6.

Department for Vascular Neurology and Intensive Neurological Therapy, University Ljubljana, Faculty of Medicine, Department of Neurology, Ljubljana, Slovenia.

Background: Rapid inactivation of dabigatran by its specific inhibitor idarucizamab allows intravenous thrombolysis (IVT) in patients suffering ischemic stroke while being treated with dabigatran. Only limited data of this approach is available and numerous questions regarding efficacy/safety remain to be answered. Herein, we present the findings from the Slovenian national cohort study. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.019DOI Listing
December 2018

Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial.

J Am Heart Assoc 2018 Dec;7(24):e009609

2 Department of Medicine Duke Clinical Research Institute Durham NC.

Background Vorapaxar, a protease-activated receptor-1 antagonist, is approved for secondary prevention of cardiovascular events but is associated with increased intracranial hemorrhage. Methods and Results TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) was a trial of vorapaxar versus placebo among patients with acute coronary syndrome. Strokes were adjudicated by a central events committee. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009609
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http://dx.doi.org/10.1161/JAHA.118.009609DOI Listing
December 2018
1 Read

Headache in Pregnancy, the Puerperium, and menopause.

Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

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http://dx.doi.org/10.1055/s-0038-1673681DOI Listing
December 2018
3 Reads

Carotid Endarterectomy for Medical Therapy-resistant Symptomatic Low-grade Stenosis.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Plaque characteristics play pivotal roles in ischemic events, but stenosis severity does not accurately reflect carotid plaque volume due to expansive remodeling in some patients with low-grade stenosis (LGS).

Objective: This study aimed to assess the safety, efficacy, and durability of carotid endarterectomy (CEA) for symptomatic LGS.

Methods: Study participants comprised 61 consecutive patients who underwent CEA for symptomatic carotid stenosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183276
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http://dx.doi.org/10.1016/j.wneu.2018.11.208DOI Listing
December 2018
5 Reads

Left Atrial Appendage Occlusion in the Management of Stroke in Patients With Atrial Fibrillation.

Cardiol Rev 2018 Dec 4. Epub 2018 Dec 4.

Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.

Atrial fibrillation (AF) is associated with a substantially higher risk of thromboembolism, particularly stroke events, resulting in significant morbidity and mortality. Oral anticoagulation (OAC), while effective in reducing embolic events in AF patients, is associated with an increased bleeding risk. Thus, not all patients with AF are candidates for OAC and some are only candidates for OAC in the short term. Read More

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http://dx.doi.org/10.1097/CRD.0000000000000240DOI Listing
December 2018
4 Reads

Links Between Strokes and Hereditary Hemorrhagic Telangiectasia: A Population-Based Study.

Can J Neurol Sci 2018 Dec 6:1-7. Epub 2018 Dec 6.

Department of Medicine, Division of Pulmonary,University of Alberta,Edmonton, Alberta,Canada.

Background: Hereditary hemorrhagic telangiectasia (HHT) is a disease of abnormal vasculature where patients are predisposed to strokes of multiple etiologies. We assessed yearly stroke incidence among Albertans with HHT and compared with the general population. Given the tendency for stroke in HHT patients, we expected HHT patients to have higher stroke incidence, in particular at younger ages. Read More

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http://dx.doi.org/10.1017/cjn.2018.360DOI Listing
December 2018
1 Read
1.599 Impact Factor

Abstract 4: Safety of Intravenous Thrombolysis Among Patients Taking Direct Oral Anticoagulants: A Systematic Review and Meta-analysis.

Stroke 2018 Jan;49(Suppl_1):A4

Dept of Neurology, Danville, PA.

Introduction: Direct oral anticoagulants (DOACs) are increasingly being administered for atrial fibrillation and stroke prevention. The risk of symptomatic hemorrhagic transformation (sHT) following intravenous thrombolysis (IVT) among stroke patients who take DOACs is not clear.

Methods: We conducted a systematic review of literature through six different resources-PubMed, Scopus, Embase, Clinicaltrial. Read More

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http://dx.doi.org/10.1161/str.49.suppl_1.4DOI Listing
January 2018
1 Read

Fibrinogen concentrate replacement in ischemic stroke patients after recombinant tissue plasminogen activator treatment.

Adv Clin Exp Med 2018 Dec 3. Epub 2018 Dec 3.

Stroke Unit, Neurology Clinic, Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Modena, Italy.

Background: Post-thrombotic intracerebral hemorrhage (ICH) is experienced by 6-8% of stroke patients and is associated with multiple factors, including acquired coagulopathy induced by the thrombolytic drug.

Objectives: The objective of this study was to assess the outcome of the intravenous (IV) administration of fibrinogen concentrate in a series of acute stroke patients who developed iatrogenic fibrinogen critical depletion after IV thrombolysis.

Material And Methods: Of the 39 ischemic stroke patients treated with IV thrombolysis with a severe hypofibrinogenemia requiring infusion with IV fibrinogen concentrate, 30 patients were treated with 2 g of IV recombinant tissue plasminogen activator (rt-PA), followed by further doses until the fibrinogen level reached 200 mg/dL in hemorrhagic patients or 100 mg/dL in non-hemorrhagic patients, and 9 were treated with IV rt-PA followed by endovascular thrombectomy. Read More

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http://dx.doi.org/10.17219/acem/84936DOI Listing
December 2018
1 Read

Mitophagy, a potential therapeutic target for stroke.

J Biomed Sci 2018 Nov 30;25(1):87. Epub 2018 Nov 30.

Heilongjiang University Of Chinese Medicine, Harbin, 150040, Heilongjiang province, China.

Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or excessive mitochondria that can generate reactive oxygen species (ROS) and cause cell death. Mitochondria are centrally implicated in neuron and tissue injury after stroke, due to the function of supplying adenosine triphosphate (ATP) to the tissue, regulating oxidative metabolism during the pathologic process, and contribution to apoptotic cell death after stroke. Read More

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http://dx.doi.org/10.1186/s12929-018-0487-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271612PMC
November 2018
1 Read

Ocular and Intracranial MR Imaging Findings in Abusive Head Trauma.

Top Magn Reson Imaging 2018 Dec;27(6):503-514

Professor of Radiology, University of Pittsburgh School of Medicine, Director of Pediatric Neuroradiology, Children Hospital of Pittsburgh, Pittsburgh, PA.

Abusive head trauma (AHT) is a form of inflicted head injury. AHT is more frequent in 2-year-old or younger children. It is an important cause of neurological impairment and the major cause of death from head trauma in this age group. Read More

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http://dx.doi.org/10.1097/RMR.0000000000000169DOI Listing
December 2018
5 Reads

Subarachnoid Hemorrhage.

Continuum (Minneap Minn) 2018 Dec;24(6):1623-1657

Purpose Of Review: This article reviews the epidemiology, clinical presentation, diagnosis, and management of patients with aneurysmal subarachnoid hemorrhage (SAH). SAH is a type of hemorrhagic stroke and is a neurologic emergency with substantial morbidity and mortality. This article reviews the most common and potentially life-threatening neurologic and medical complications to promote their early recognition and prevent secondary brain injury. Read More

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http://dx.doi.org/10.1212/CON.0000000000000679DOI Listing
December 2018
2 Reads

Increased Neutrophil-to-lymphocyte Ratios are Associated with Greater Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.

Curr Neurovasc Res 2018 Dec 4. Epub 2018 Dec 4.

Center of Cerebrovascular Disease, Department of Neurology, West China Hospital, Sichuan University, Chengdu. China.

Background And Purpose: Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of hemorrhagic transformation (HT) after acute ischemic stroke (AIS).

Methods: Patients within seven days after stroke onset were included between January 2016 and October 2017. The laboratory data were collected within 24 hours after admission. Read More

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http://dx.doi.org/10.2174/1567202616666181204122457DOI Listing
December 2018
1 Read

The Management of Acute Ischemic Strokes and the Prevalence of Large Vessel Occlusion in Left Ventricular Assist Device.

Cerebrovasc Dis 2018 Dec 4;46(5-6):213-217. Epub 2018 Dec 4.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio,

Background: Ischemic and hemorrhagic strokes are frequent complications among those with left ventricular assist device (LVAD). Scarce data exist regarding the prevalence of acute large vessel occlusion (LVO) and treatment of acute ischemic stroke (AIS) in this setting.

Methods: We reviewed prospectively collected data of LVAD patient registry from a single, tertiary center from October 2004 to November 2016. Read More

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http://dx.doi.org/10.1159/000495080DOI Listing
December 2018
4 Reads

Pediatric Hemorrhagic Stroke Complicates Interventions for Congenital Heart Disease: Experiences from Two Centers.

Chin Med J (Engl) 2018 Dec;131(23):2862-2863

Department of Pediatric Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.

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http://dx.doi.org/10.4103/0366-6999.246070DOI Listing
December 2018

Alleviation of mechanical allodynia by 14,15-EET in a central post-stroke pain model: possible role of allopregnanolone and δGABAR.

J Pain 2018 Nov 27. Epub 2018 Nov 27.

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Central post-stroke pain (CPSP) is a neuropathic pain syndrome arising after lesion of the central nervous system (CNS) due to cerebrovascular insult. Impaired daily activities and reduced quality of life in people suffering from CPSP justify the need for improved treatment. The detailed mechanism of CPSP is not well understood but central disinhibition has been suggested. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183091
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http://dx.doi.org/10.1016/j.jpain.2018.11.006DOI Listing
November 2018
2 Reads

Postpartum anticoagulation in women with mechanical heart valves.

Int J Womens Health 2018 25;10:663-670. Epub 2018 Oct 25.

Department of Obstetrics, Gynecology and Reproductive Sciences, Section of Maternal-Fetal Medicine, Yale University School of Medicine, New Haven, CT, USA,

Background: Women with mechanical heart valves (MHV) requiring anticoagulation (AC) are at high risk for hemorrhagic complications. Despite guidelines to manage antenatal and peripartum AC, there are few evidence-based recommendations to guide the initiation of postpartum AC. We reviewed our institutional experience of pregnant women with MHV to lay the groundwork for recommendations of immediate postpartum AC therapy. Read More

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https://www.dovepress.com/postpartum-anticoagulation-in-wome
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http://dx.doi.org/10.2147/IJWH.S177547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207249PMC
October 2018
5 Reads

A Direct Aspiration First Pass Technique in Japanese Real-World Clinical Setting.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosurgery, Baba Memorial Hospital, Osaka, Japan.

Background: It is debatable whether mechanical thrombectomy has benefits in a real-world setting outside the more rigid and selective clinical trial environment.

Objective: To evaluate clinical outcomes, efficacy, and safety of mechanical thrombectomy in single-center retrospective cohort case series.

Methods: We reviewed prospectively collected data from our large-vessel occlusion stroke database to identify patients undergoing mechanical thrombectomy using Penumbra catheters (Penumbra, Almeida, California) as first-line devices. Read More

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http://dx.doi.org/10.1093/ons/opy349DOI Listing
November 2018
1 Read

"Branched tail" oxyquinoline inhibitors of HIF prolyl hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip.

Drug Metab Lett 2018 Nov 28. Epub 2018 Nov 28.

Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology and Immunology, Healthcare Ministry of Russia, 117997 Moscow. Russian Federation.

Background: "Branched tail" oxyquinolines, and adaptaquin in particular, are potent HIF prolyl hydroxylase inhibitors showing promising results in in vivo hemorrhagic stroke models. The further improvement of the potency resulted in identification of a number of adaptaquin analogs. Early evaluation of toxicity and metabolism is desired right at the step of lead selection. Read More

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http://dx.doi.org/10.2174/1872312813666181129100950DOI Listing
November 2018

Cerebral vasospasm after endoscopic fenestration of a temporal arachnoid cyst in a child-a case report and review of the literature.

Childs Nerv Syst 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosurgery, Faculty of Medicine, Saarland University Medical Center and Saarland University, Gebäude 90.5, 66421, Homburg/Saar, Germany.

Introduction: Intracranial arachnoid cysts (ACs) represent rare extra-axial CSF-containing lesions. Surgical management mainly depends on the cyst location and its size. Nevertheless, pure endoscopic fenestration represents a relatively straightforward and safe technique, and-in most cases-the treatment of choice for symptomatic intracranial ACs. Read More

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http://dx.doi.org/10.1007/s00381-018-4011-7DOI Listing
November 2018
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Stroke in Patients with Infective Endocarditis: A 15-Year Single-Center Cohort Study.

Eur Neurol 2018 Nov 28;80(3-4):171-178. Epub 2018 Nov 28.

Department of Neurology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: To explore the relationship between infective endocarditis (IE) and stroke.

Methods: The clinical data of patients diagnosed with IE from January 2003 to December 2017 in Beijing Anzhen Hospital Affiliated to Capital Medical University were retrospectively analyzed.

Results: A total of 861 patients (mean age: 40. Read More

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http://dx.doi.org/10.1159/000495149DOI Listing
November 2018
3 Reads

Clinical presentation, risk factors and outcome of central nervous system metastasis vs stroke in cancer patients.

Curr Probl Cancer 2018 Nov 16. Epub 2018 Nov 16.

Neuro-oncology Unit, Research Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.

Background And Purpose: Cancer and stroke are the second and third causes of death worldwide; brain metastases (BM) occur in one third of patients with cancer, any neurologic deficit in these population always prompts the clinician to discard metastases for their presence carries a bad outcome. Both might share clinical presentation and differences in their outcome are not entirely known. The aim was to compare risk factors, clinical presentation, and outcome of cancer patients with BM vs stroke. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2018.09.001DOI Listing
November 2018
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Minimally invasive management of spontaneous supratentorial intracerebral lobar hemorrhages by a "home made" endoscopic strategy. The evangelic doctrine of "venite ad me" allied to the legacy of King Leonida.

World Neurosurg 2018 Nov 24. Epub 2018 Nov 24.

Neurosurgical Clinic, AOUP "Paolo Giaccone", PostGraduate Residency Program in Neurologic Surgery,Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, University ofPalermo, 90127 Palermo, Italy.

Background: While the incidence of intracerebral haemorrhage (ICH) appear to be increasing over the year, its prognosis still remains dismal . Although no consensus about the management of ICH has be found, minimal invasive surgery should limit - when not avoid - the intra operative parenchymal damage. At this regard, we present a novel modified "home made" approach, aimed to shorten the operative time and minimize the corticectomy and brain manipulation, with our clinical series. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183269
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http://dx.doi.org/10.1016/j.wneu.2018.11.136DOI Listing
November 2018
3 Reads

Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial.

Int J Stroke 2018 Nov 26:1747493018816451. Epub 2018 Nov 26.

1 Stroke, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.

Background: High blood pressure is common in acute stroke and associated with a worse functional outcome. Glyceryl trinitrate, a nitric oxide donor, lowers blood pressure in acute stroke and may improve outcome.

Aims: Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) tested the feasibility of performing a UK multicenter ambulance-based stroke trial, and the safety and efficacy of glyceryl trinitrate when administered by paramedics before hospital admission. Read More

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http://dx.doi.org/10.1177/1747493018816451DOI Listing
November 2018
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Outcomes of intraparenchymal hemorrhage after direct oral anticoagulant or vitamin K antagonist therapy: A systematic review and meta-analysis.

J Clin Neurosci 2018 Nov 21. Epub 2018 Nov 21.

Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurosurgery, Brain Center Rudolf Magnus University Medical Center Utrecht, Utrecht, the Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Direct Oral Anticoagulants (DOAC) are increasingly used as an alternative to vitamin-K antagonists (VKA) for anticoagulation and have shown lower rates of intracranial hemorrhage; however, there is disagreement in the literature over the outcomes of the intraparenchymal hemorrhages (IPH) associated with DOACs, and clinical concern regarding the lack of standardized reversal strategies for DOACs. Thus, the aim of this meta-analysis was to compare mortality, hematoma volume, and risk of hematoma expansion in patients who developed an IPH on DOACs versus VKA. A systematic review of the literature was conducted in accordance with the PRISMA guidelines. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.032DOI Listing
November 2018
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Fish Consumption and Stroke Risk: A Meta-Analysis of Prospective Cohort Studies.

J Stroke Cerebrovasc Dis 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurosurgery, Nanchong Central Hospital (The Second Clinical College of North Sichuan Medical College), Nanchong, Sichuan, China.

Background: Inconsistent results of the association between fish consumption and stroke risk have been indicated in previous epidemiological studies. Therefore, we performed a meta-analysis of prospective cohort studies to estimate the impact of fish consumption on stroke risk.

Methods: The PubMed and EMBASE databases were searched through a computer search. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.036DOI Listing
November 2018
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Stroke in Pregnancy: An Update.

Neurol Clin 2019 Feb;37(1):131-148

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, WACC 729-C, Boston, MA 02114, USA. Electronic address:

Pregnancy confers a substantially increased risk of stroke in women. The period of highest risk of stroke is the peripartum/postpartum phase, coinciding with the highest risk for hypertensive disorders of pregnancy and peak gestational hypercoagulability. Hemorrhagic stroke is the most common type of obstetric stroke. Read More

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http://dx.doi.org/10.1016/j.ncl.2018.09.010DOI Listing
February 2019
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Reduced Risks of Both Ischemic and Hemorrhagic Strokes in Nurses: A Population-Based Cohort Study in Taiwan.

Int J Environ Res Public Health 2018 11 22;15(12). Epub 2018 Nov 22.

Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan.

Background: Nurses are typically required to address patient emergencies, and they experience high stress levels in their work, which may expose them to a higher risk of stroke. This cohort study compared the risk of stroke between nurses and the general population.

Methods: We used the Taiwan National Health Insurance database to conduct our retrospective cohort study, and we identified 83,641 individuals in the nurse group and 334,564 individuals in the control group. Read More

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http://dx.doi.org/10.3390/ijerph15122615DOI Listing
November 2018
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In Reply to "Predictors of Outcome in Spontaneous Intracerebral Hemorrhage-Role of Oxidative Stress Biomarkers".

World Neurosurg 2018 12;120:602

Research Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.1016/j.wneu.2018.08.226DOI Listing
December 2018

Predictors of Outcome in Spontaneous Intracerebral Hemorrhage-Role of Oxidative Stress Biomarkers.

World Neurosurg 2018 12;120:601

Department of Critical Care Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183201
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http://dx.doi.org/10.1016/j.wneu.2018.08.222DOI Listing
December 2018
2 Reads