12,118 results match your criteria Stroke Hemorrhagic


Psychological Outcome after Hemorrhagic Stroke is Related to Functional Status.

J Stroke Cerebrovasc Dis 2022 May 17;31(8):106492. Epub 2022 May 17.

NYU Langone Medical Center, Department of Neurology, NY 10016, New York; NYU Langone Medical Center, Department of Neurosurgery, NY 10016, New York. Electronic address:

Background: To identify opportunities to improve morbidity after hemorrhagic stroke, it is imperative to understand factors that are related to psychological outcome.

Design/methods: We prospectively identified patients with non-traumatic hemorrhagic stroke (intracerebral or subarachnoid hemorrhage) between January 2015 and February 2021 who were alive 3-months after discharge and telephonically assessed 1) psychological outcome using the Quality of Life in Neurological Disorders anxiety, depression, emotional and behavioral dyscontrol, fatigue and sleep disturbance inventories and 2) functional outcome using the modified Rankin Scale (mRS) and Barthel Index. We also identified discharge destination for all patients. Read More

View Article and Full-Text PDF

Therapeutic effect of anti-HMGB1 antibody in a mouse model of 4-h middle cerebral artery occlusion: comparison with tissue plasminogen activator.

Neuroreport 2022 May 8;33(7):297-303. Epub 2022 Apr 8.

Department of Physiology and Pharmacology.

Objective: Delayed tissue plasminogen activator (tPA) treatment increases the risk of intracerebral hemorrhage in patients with ischemic stroke. We previously demonstrated that tPA treatment caused hemorrhagic complications in a 4-h middle cerebral artery occlusion (MCAO) mouse model when administered after reperfusion. In the present study, we administered an anti-high mobility group box 1 (αHMGB1) antibody to 4-h MCAO mice to evaluate the usability of αHMGB1 antibody treatment in the delayed phase of ischemia, beyond the therapeutic time window of tPA. Read More

View Article and Full-Text PDF

Cryoprecipitate for Alteplase-Related Hemorrhagic Conversion of Acute Ischemic Stroke.

J Pharm Pract 2022 May 20:8971900221102116. Epub 2022 May 20.

159947NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, USA.

Evidence to support cryoprecipitate for reversal of alteplase-related hemorrhagic conversion of acute ischemic stroke is limited. Guidelines recommend cryoprecipitate as first line treatment, followed by aminocaproic acid as a conditional recommendation with very low-quality evidence. The purpose of this case series was to describe the use of cryoprecipitate for alteplase-related hemorrhagic conversion of acute ischemic stroke. Read More

View Article and Full-Text PDF

Potential association between bacterial infections and ischemic stroke based on fifty case-control studies: A systematic review and meta-analysis.

New Microbes New Infect 2022 Apr-May;47:100980. Epub 2022 Apr 15.

Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.

Background: Stroke is considered as one of the most important concerns in health care centers around the world. By definition there are two types of stroke including ischemic stroke and hemorrhagic stroke. Approximately three-quarters of stroke cases are ischemic strokes, which occur due to several risk factors such as hypertension, obesity, atherosclerosis, diabetes mellitus, osteoarthritis, and inflammatory responses. Read More

View Article and Full-Text PDF

Increased Risk of Cardio-Cerebrovascular Diseases in Migraine Patients: A Nationwide Population-Based, Longitudinal Follow-Up Study in South Korea.

J Clin Neurol 2022 May;18(3):323-333

Department of Data Science, Hanmi Pharm. Co., Ltd., Seoul, Korea.

Background And Purpose: Migraine is reportedly associated with several cardio-cerebrovascular diseases (CCDs), but some of these diseases have not received sufficient attention. We thus attempted to determine the associations of migraine with peripheral arterial disease (PAD), ischemic heart disease (IHD), atrial fibrillation/flutter (AF), ischemic stroke (IS), and hemorrhagic stroke (HS).

Methods: The study population was recruited by applying International Classification of Diseases, Tenth Revision (ICD-10) codes to the database of the Korean National Health Insurance Service from 2002 to 2018. Read More

View Article and Full-Text PDF

Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats.

Brain Res Bull 2022 May 16;185:162-173. Epub 2022 May 16.

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; Institute of Stroke Research, Soochow University, Suzhou 215006, China. Electronic address:

Subarachnoid hemorrhage (SAH), a type of hemorrhagic stroke, is a neurological emergency with high morbidity and mortality. Early brain injury (EBI) after SAH is the leading cause of poor prognosis in SAH patients. TRX system is a NADPH-dependent antioxidant system which is composed of thioredoxin reductase (TRXR), thioredoxin (TRX). Read More

View Article and Full-Text PDF

Comparison of Stroke Risk Factors Between Symptomatic and Asymptomatic Patients in a North American Moyamoya Disease Cohort.

Cerebrovasc Dis Extra 2022 May 19. Epub 2022 May 19.

Background: Risk factors for stroke in symptomatic and asymptomatic moyamoya disease (MMD) patients has recently been reported in a Japanese cohort. Such information in a North American population is lacking.

Objective: We sought to elucidate the prevalence of stroke risk factors among North American patients with ischemic, hemorrhagic, and asymptomatic MMD. Read More

View Article and Full-Text PDF

[Haemorrhagic Stroke after Snakebite Envenomation Resulting in Irreversible Blindness in a 6-Year-Old Child in Mali].

Med Trop Sante Int 2021 Sep 29;1(3). Epub 2021 Jul 29.

Faculté de médecine et d'odontostomatologie, USTTB, Bamako, Mali.

Introduction: Snakebite envenomation can cause serious damage. Here, we report the case of a six-year-old male child bitten by a snake.

Clinical Description: The child presented a gingivorrhagia, abdominal pain, bloody vomiting and severe headache from a snakebite. Read More

View Article and Full-Text PDF
September 2021

Minimally Invasive Surgery for Spontaneous Intracerebral Hematoma. Real-Life Implementation Model and Economic Estimation.

Front Neurol 2022 2;13:884157. Epub 2022 May 2.

Department of Neurosurgery, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Objective: Spontaneous intracerebral hemorrhage is characterized by high fatality outcomes, even under best medical treatment. Recently, minimally invasive surgical (MIS) evacuation of the hematoma has shown promising results and may soon be implemented in the clinical practice. Hereby, we intended to foresee the logistic requirements for an early hematoma evacuation protocol, as well as to evaluate in a real-life implementation model the cost-utility of the two main MIS techniques for hemorrhagic stroke (catheter evacuation plus thrombolysis and neuroendoscopic aspiration). Read More

View Article and Full-Text PDF

Relationships between Age at Menarche and Risk of Cardiovascular Disease Mortality among Japanese Women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study.

J Atheroscler Thromb 2022 May 18. Epub 2022 May 18.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine.

Aim: In this study, we aimed to evaluate the association between age at menarche and risk of cardiovascular disease mortality.

Methods: In total, 54,937 women aged 40-79 years old between 1988 and 1990 without a history of cardiovascular disease were eligible for analysis and were followed through December 2009. We used the Cox proportional hazards models to examine the association between age at menarche and risk of cardiovascular disease. Read More

View Article and Full-Text PDF

Poststroke Seizures and the Risk of Dementia Among Young Stroke Survivors.

Neurology 2022 May 18. Epub 2022 May 18.

Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.

Background: The impact of new onset seizures in young stroke survivors on the subsequent development of dementia is poorly understood. This study aimed to assess the association between new onset of seizure and dementia in a population-based study of stroke patients.

Methods: The IBM Watson Health MarketScan® Commercial Claims and Encounters database, for the years 2005-2014 served as the data source for this study. Read More

View Article and Full-Text PDF

Paradoxical venous air embolism detected with point-of-care ultrasound: a case report.

Ultrasound J 2022 May 18;14(1):19. Epub 2022 May 18.

Cuidado Crítico, Hospital Universitario Nacional de Colombia, Bogotá D.C, Colombia.

Venous air embolism (VAE) is an uncommon event consistent in the entrainment of air from any communication between the environment and the venous vasculature that could occur during central venous catheter (CVC) manipulation, and might trigger circulatory shock within minutes depending on the amount of air embolized. We present a case of a critical care patient who presented sudden clinical hemodynamic deterioration after the removal of central venous catheter. Hemodynamic evaluation with point-of-care ultrasound (POCUS) showed bubbles in both right and left heart cavities wherewith air embolism facilitated by heart septal defect was suspected. Read More

View Article and Full-Text PDF

Emergency Cervical Carotid Artery Stenting After Intravenous Thrombolysis in Patients With Hyperacute Ischemic Stroke.

J Korean Med Sci 2022 May 16;37(19):e156. Epub 2022 May 16.

Department of Neurology, Keimyung University School of Medicine, Daegu, Korea.

Background: Intravenous recombinant tissue plasminogen activator (IV rtPA) is the mainstay of treatment for acute ischemic stroke to recanalize thrombosed intracranial vessels within 4.5 hours. Emergency carotid artery stenting for the treatment of acute stroke due to steno-occlusion of the proximal internal carotid artery (ICA) can improve symptoms, prevent neurological deterioration, and reduce recurrent stroke risk. Read More

View Article and Full-Text PDF

Reduced anticoagulation targets in extracorporeal life support (RATE): study protocol for a randomized controlled trial.

Trials 2022 May 16;23(1):405. Epub 2022 May 16.

Department of Critical Care, University Medical Center Groningen, Room R3.904, PO BOX 30001, 9700, RB, Groningen, The Netherlands.

Background: Although life-saving in selected patients, ECMO treatment still has high mortality which for a large part is due to treatment-related complications. A feared complication is ischemic stroke for which heparin is routinely administered for which the dosage is usually guided by activated partial thromboplastin time (aPTT). However, there is no relation between aPTT and the rare occurrence of ischemic stroke (1. Read More

View Article and Full-Text PDF

CAROTID ENADRTERECTOMY FOR INTERNAL CAROTID THROMBOSIS IN PATIENTS WITH COVID-19.

Curr Probl Cardiol 2022 05 13:101252. Epub 2022 May 13.

Research Institute - Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky

Goal: Analysis of the results of emergency carotid endarterectomy (CEE) against the background of internal carotid artery (ICA) thrombosis in the acute period of acute cerebrovascular accident (ACVI) in patients with COVID-19 MATERIAL AND METHODS: During the COVID-19 pandemic (April 1, 2020 - May 1, 2021), 43 patients with ICA thrombosis and a positive polymerase chain reaction (PCR) result for SARS-CoV-2 were included in this prospective study. In all cases, CEE was performed in the acutest period of ACVA. These patients were included in group 1. Read More

View Article and Full-Text PDF

Systemic White Blood Cell Count as a Biomarker for Malignant Cerebral Edema in Large Vessel Ischemic MCA Stroke.

J Stroke Cerebrovasc Dis 2022 May 13;31(8):106550. Epub 2022 May 13.

Southern Illinois University Neuroscience Institute, United States.

Objectives: Large middle cerebral artery (MCA) strokes remain a major cause for mortality and morbidity all over the world, and therefore early identification of patients with the highest risk for malignant cerebral edema is crucial for early intervention. Neutrophils to lymphocytes ratio (NLR) and peripheral total white blood cell (WBC) count are inflammatory markers done routinely for all patients, and this study evaluated the use of NLR and elevated white blood cell count within the first 24 h of MCA ischemic stroke onset, with the absence of significant hemorrhagic transformation, to predict malignant cerebral edema.

Materials And Methods: A total of 156 patients with large MCA strokes were included. Read More

View Article and Full-Text PDF

Thrombolytic tPA-Induced Hemorrhagic Transformation of Ischemic Stroke is Mediated by PKCβ phosphorylation of Occludin.

Blood 2022 May 16. Epub 2022 May 16.

University of Michigan, United States.

The current standard of care for moderate to severe ischemic stroke is thrombolytic therapy with tissue plasminogen activator (tPA). Treatment with tPA can significantly improve neurological outcomes; however, thrombolytic therapy is associated with an increased risk of intracerebral hemorrhage (ICH). The risk of hemorrhage significantly limits the use of thrombolytic therapy and identifying pathways induced by tPA that increase this risk could provide new therapeutic options to extend thrombolytic therapy to a wider patient population. Read More

View Article and Full-Text PDF

Improving Extracorporeal Membrane Oxygenation Survival in COVID-19. Effect of a Bundle of Care.

ASAIO J 2022 May 16. Epub 2022 May 16.

From the Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia.

Veno-venous extracorporeal membrane oxygenation (ECMO) support surged during the COVID-19 pandemic. Our program changed the model of care pursuing to protect the multidisciplinary team from the risk of infection and to serve as many patients as possible. Patient-healthcare interactions were restricted, and the ECMO bed capacity was increased by reducing the ECMO specialist-patient ratio to 1:4 with non-ECMO trained nurses support. Read More

View Article and Full-Text PDF

Early Versus Late Tracheostomy in Spontaneous Intracerebral Hemorrhage.

Cureus 2022 Apr 12;14(4):e24059. Epub 2022 Apr 12.

Neurosurgery, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.

Introduction: Recent literature supports early tracheostomy (<=7 days) over delayed tracheostomy (>7 days-3 months) to improve overall clinical outcomes for patients admitted with an acute head injury. There is conflicting evidence for the same in hemorrhagic stroke. Using a multi-institutional database, we explored this question in nontraumatic spontaneous intracerebral hemorrhage (sICH) patients. Read More

View Article and Full-Text PDF

Transient Ischemic Attack Due to Unruptured Basilar Artery Aneurysm.

Cureus 2022 Apr 13;14(4):e24102. Epub 2022 Apr 13.

Neurology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.

Intracranial aneurysms are typically asymptomatic. They are usually incidentally detected or detected only after rupture. Ischemic stroke or transient ischemic attack (TIA) due to unruptured intracranial aneurysms (UIAs) is rare. Read More

View Article and Full-Text PDF

Extracorporeal membrane oxygenation support in children with severe coronavirus disease-2019: A case series.

Lancet Reg Health Am 2022 Jul 7;11:100260. Epub 2022 May 7.

Hospital Dr. Carlos Alberto Studart Gomes, Av. Washington Soares, 1321 - Edson Queiroz, Fortaleza, CE CEP 60811-905, Brazil.

Background: The coronavirus disease-2019 (COVID-19) pandemic has predominantly affected the adult population, but with a significantly lower prevalence in children. Most pediatric patients with COVID-19 have mild course; however, a small number progressed to acute respiratory distress syndrome, hypoxemia, despite optimized conventional therapies. Thus, this study aimed to report a series of six cases of children with severe acute respiratory syndrome coronavirus 2 infection who were supported by extracorporeal membrane oxygenation (ECMO) due to refractory hypoxemic respiratory failure. Read More

View Article and Full-Text PDF

Ischemic Stroke-A Scientometric Analysis.

Front Neurol 2022 28;13:893121. Epub 2022 Apr 28.

Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany.

Background: Stroke is the second leading cause of death world-wide. A comprehensive scientometric study regarding ischemic stroke research has not been performed yet. This study aims at investigating the global research output on ischemic stroke research. Read More

View Article and Full-Text PDF

Curcumin Restrains Oxidative Stress of After Intracerebral Hemorrhage in Rat by Activating the Nrf2/HO-1 Pathway.

Front Pharmacol 2022 27;13:889226. Epub 2022 Apr 27.

Affiliated Hospital of Hebei University, Baoding, China.

Intracerebral hemorrhage (ICH), a severe hemorrhagic stroke, induces cerebral oxidative stress and severe secondary neurological injury. Curcumin was demonstrated to inhibit oxidative stress in the brain after ICH. However, the pharmacological mechanism needs further research. Read More

View Article and Full-Text PDF

Pulmonary arteriovenous malformation and inherent complications with solitary lung nodule biopsy-literature overview and case report.

Radiol Case Rep 2022 Jul 6;17(7):2353-2361. Epub 2022 May 6.

Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

Pulmonary arteriovenous malformation, also known as an arteriovenous fistula, is typically a congenital disease caused by structural deficiencies, particularly the lack of capillary wall development, leading to the abnormal dilation of the pulmonary capillaries. The majority of pulmonary arteriovenous malformation cases are associated with Rendu-Osler-Weber syndrome, also known as hereditary hemorrhagic telangiectasia. Pulmonary arteriovenous malformation rarely occurs due to chest trauma. Read More

View Article and Full-Text PDF

Hereditary Hemorrhagic Telangiectasia and Arterio-Venous Malformations-From Diagnosis to Therapeutic Challenges.

J Clin Med 2022 May 7;11(9). Epub 2022 May 7.

Sf. Spiridon Emergency Hospital, 700111 Iași, Romania.

Hereditary hemorrhagic telangiectasia is a rare autosomal dominant vascular disease defined by the presence of mucosal and cutaneous telangiectasia and visceral arterio-venous malformations. The latter are abnormal capillary-free direct communications between the pulmonary and systemic circulations with the following consequences: arterial hypoxemia caused by right-to-left shunts; paradoxical embolism with transient ischemic attack or stroke and brain abscess caused by the absence of the normally filtering capillary bed; and hemoptysis or hemothorax due to the rupture of the thin-walled arterio-venous malformations (particularly during pregnancy). It is frequently underdiagnosed, commonly presenting as complications from shunting through arterio-venous malformations: dyspnea, chronic bleeding, or embolism. Read More

View Article and Full-Text PDF

Cerebral Cavernous Malformation Pathogenesis: Investigating Lesion Formation and Progression with Animal Models.

Int J Mol Sci 2022 Apr 30;23(9). Epub 2022 Apr 30.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Cerebral cavernous malformation (CCM) is a cerebromicrovascular disease that affects up to 0.5% of the population. Vessel dilation, decreased endothelial cell-cell contact, and loss of junctional complexes lead to loss of brain endothelial barrier integrity and hemorrhagic lesion formation. Read More

View Article and Full-Text PDF

Prevalence of dysphagia and risk of pneumonia and mortality in acute stroke patients: a meta-analysis.

BMC Geriatr 2022 May 13;22(1):420. Epub 2022 May 13.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.

Background: Post-stroke dysphagia (PSD) has been associated with high risk of aspiration pneumonia and mortality. However, limited evidence on pooled prevalence of post-stroke dysphagia and influence of individual, disease and methodological factors reveals knowledge gap. Therefore, to extend previous evidence from systematic reviews, we performed the first meta-analysis to examine the pooled prevalence, risk of pneumonia and mortality and influence of prognostic factors for PSD in acute stroke. Read More

View Article and Full-Text PDF

Lipid-Modifying Therapies and Stroke Prevention.

Curr Neurol Neurosci Rep 2022 May 13. Epub 2022 May 13.

Division of Endocrinology and Metabolism, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Canada.

Purpose Of Review: We reviewed lipid-modifying therapies and the risk of stroke and other cerebrovascular outcomes, with a focus on newer therapies.

Recent Findings: Statins and ezetimibe reduce ischemic stroke risk without increasing hemorrhagic stroke risk. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors similarly reduce ischemic stroke risk in statin-treated patients with atherosclerosis without increasing hemorrhagic stroke, even with very low achieved low-density lipoprotein cholesterol levels. Read More

View Article and Full-Text PDF

The Role of Cumulative Mean Arterial Pressure Levels in First Stroke Events Among Adults with Hypertension: A 10-Year Prospective Cohort Study.

Clin Epidemiol 2022 4;14:665-676. Epub 2022 May 4.

School of Public Health, Southeast University, Nanjing, People's Republic of China.

Background: Mean arterial pressure (MAP) has been proved to be an independent risk factor for stroke. In this study, we explored whether cumulative exposure of MAP in patients with hypertension is more associated with the occurrence of stroke.

Methods: In this prospective follow-up cohort study of hypertension from June 2010 to May 2020, 9136 participants without previous stroke at recruitment were included, of whom 492 (5. Read More

View Article and Full-Text PDF

Plasma Inflammatory Markers and Ventriculostomy-Related Infection in Patients With Hemorrhagic Stroke: A Retrospective and Descriptive Study.

Front Neurol 2022 25;13:861435. Epub 2022 Apr 25.

Neurocritical Care Unit, Department of Neurosurgery and Institute for Intensive Care Medicine, University Hospital Zürich, Zürich, Switzerland.

Background: Diagnosis of ventriculostomy-related infection (VRI) remains difficult due to the various existing definitions. In patients with hemorrhagic stroke, its diagnosis might be further complicated by the presence of intraventricular blood. Furthermore, hemorrhagic stroke may cause symptoms compatible with VRI. Read More

View Article and Full-Text PDF