305,360 results match your criteria Stroke; a journal of cerebral circulation[Journal]


Acute Stroke and Attenuation in Endothelial Progenitor Cells: Cause or Effect?

Isr Med Assoc J 2019 Feb;21(2):120-121

Department of Cardiology, Assuta Ashdod Medical Center, Ashdod, affiliated with Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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February 2019

Ultrasound-Guided Botulinum Toxin Injections into the Salivary Glands for the Treatment of Drooling.

Isr Med Assoc J 2019 Feb;21(2):116-119

Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Drooling is the unintentional loss of saliva from the mouth, usually caused by poor coordination of the swallowing mechanism. It is commonly seen in patients with chronic neurologic disorders, such as Parkinson's disease, amyotrophic lateral sclerosis (ALS), cerebral palsy, and stroke, as well as in patients with cognitive impairment and dementia.

Objectives: To evaluate the efficacy and safety of ultrasound-guided botulinum toxin injections into the parotid and submandibular salivary glands for the treatment of drooling. Read More

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February 2019

Inhibition of endothelial Progenitor Cells Inhibition in the first 24 hours of an Acute Ischemic Cerebrovascular Event.

Isr Med Assoc J 2019 Feb;21(2):71-76

Department of Medicine, Padeh Medical Center, Poriya, Israel.

Background: Endothelial progenitor cells may have a role in ongoing endothelial repair. Impaired mobilization or depletion of these cells may contribute to progression of vascular disease. Our hypothesis was that endothelial progenitor cells would be suppressed in patients with acute cerebrovascular event based on our previous study that found severe endothelial dysfunction in those patients. Read More

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February 2019

Circle of Willis variations in migraine patients with ischemic stroke.

Brain Behav 2019 Feb 16:e01223. Epub 2019 Feb 16.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine.

Materials And Methods: Participants were recruited from the prospective Dutch acute Stroke Study. Read More

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http://dx.doi.org/10.1002/brb3.1223DOI Listing
February 2019

Statins for primary prevention in adults aged 75 years and older: A nationwide population-based case-control study.

Atherosclerosis 2019 Feb 2;283:28-34. Epub 2019 Feb 2.

Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background And Aims: There is inadequate evidence to establish statin treatment for primary prevention in the elderly. This study evaluated whether statins are beneficial for primary prevention of cardiovascular disease (CVD) and all-cause death in adults aged ≥ 75 years.

Methods: A nationwide, nested case-control study was conducted in Korea. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.030DOI Listing
February 2019

NT-pro-BNP correlates with disease severity and predicts outcome in cerebral haemorrhage patients: Cohort study.

J Neurol Sci 2019 Feb 8;399:51-56. Epub 2019 Feb 8.

Internal Medicine Department, São João Hospital Centre, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Stroke Unit, São João Hospital Centre, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.

Background: Intracerebral haemorrhage (ICH) is a devastating condition, with more than half of patients dying or becoming dependent after such an event. Natriuretic peptides, frequently used in the management of heart failure, have been shown to correlate with disease severity and prognosis in brain disorders. The aim of this study was to test the hypothesis that NT-pro-BNP correlates with disease severity and is an independent prognostic marker for non-traumatic ICH patients. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.014DOI Listing
February 2019

Structural brain network measures are superior to vascular burden scores in predicting early cognitive impairment in post stroke patients with small vessel disease.

Neuroimage Clin 2019 Feb 5;22:101712. Epub 2019 Feb 5.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.

Objectives: In this cross-sectional study, we aimed to explore the mechanisms of early cognitive impairment in a post stroke non-dementia cerebral small vessel disease (SVD) cohort by comparing the SVD score with the structural brain network measures.

Method: 127 SVD patients were recruited consecutively from a stroke clinic, comprising 76 individuals with mild cognitive impairment (MCI) and 51 with no cognitive impairment (NCI). Detailed neuropsychological assessments and multimodal MRI were performed. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101712DOI Listing
February 2019

Basilar occlusion and rupture secondary to rare fungal sinusitis: A case report.

World Neurosurg 2019 Feb 14. Epub 2019 Feb 14.

Lyerly Neurosurgery / Baptist Health, Baptist Neurological Institute, Jacksonville, FL.

Background: Intracranial vascular infections of fungal etiology are extremely rare. The vast majority of cases occur in immunocompromised patients with invasive fungal disease, most commonly originating in the paranasal sinuses or the lungs. An extremely rare type in this part of the world, called Granulomatous Invasive Rhinosinusitis, has been reported to affect immunocompetent patients in most cases, and its causative strain has potential to invade the intracranial arteries. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.179DOI Listing
February 2019

Heparin during endovascular stroke treatment seems safe Heparin during endovascular stroke treatment does not ameliorate clinical outcome and is associated with lower chance of reperfusion.

J Neuroradiol 2019 Feb 14. Epub 2019 Feb 14.

Comprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. Electronic address:

Background And Purpose: the effect of intravenous heparin during mechanical thrombectomy for acute ischemic stroke is not clear. We aimed to study efficacy and safety of heparin use during endovascular stroke treatment in a real-world setting.

Materials And Methods: patients with anterior circulation stroke were divided, based on the use of intraprocedural heparin, in those treated and those untreated. Read More

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http://dx.doi.org/10.1016/j.neurad.2019.01.095DOI Listing
February 2019

Transcarotid Approach for Transcatheter Aortic Valve Replacement With the Sapien 3 Prosthesis: A Multicenter French Registry.

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Lille University Hospital, Lille, France. Electronic address:

Objectives: This study sought to describe the procedural and clinical outcomes of patients undergoing transcarotid (TC) transcatheter aortic valve replacement (TAVR) with the Edwards Sapien 3 device.

Background: The TC approach for TAVR holds the potential to become the optimal alternative to the transfemoral gold standard. Limited data exist regarding safety and efficacy of TC-TAVR using the Edwards Sapien 3 device. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.11.014DOI Listing
February 2019

Medication-related risk factors and its association with repeated hospital admissions in frail elderly: A case control study.

Res Social Adm Pharm 2019 Feb 13. Epub 2019 Feb 13.

University of Bradford, School of Pharmacy and Medical Sciences, Bradford, UK.

Background: Repeated hospital admissions are prevalent in older people. The role of medication in repeated hospital admissions has not been widely studied. The hypothesis that medication-related risk factors for initial hospital admissions were also associated with repeated hospital admissions was generated. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.02.001DOI Listing
February 2019

Clinical utility and prospective of TMS-EEG.

Clin Neurophysiol 2019 Jan 19. Epub 2019 Jan 19.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) has emerged as a powerful tool to non-invasively probe brain circuits in humans, allowing for the assessment of several cortical properties such as excitability and connectivity. Over the past decade, this technique has been applied to various clinical populations, enabling the characterization and development of potential TMS-EEG predictors and markers of treatments and of the pathophysiology of brain disorders. The objective of this article is to present a comprehensive review of studies that have used TMS-EEG in clinical populations and to discuss potential clinical applications. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.001DOI Listing
January 2019

Reproducibility of semi-automated three-dimensional volumetric analysis using cardiac computed tomography in patients with left ventricular assist device.

Cardiovasc Revasc Med 2019 Jan 23. Epub 2019 Jan 23.

MedStar Washington Hospital Center, Washington, D.C., United States of America; MedStar Cardiovascular Research Network, Washington, D.C., United States of America. Electronic address:

Background: Multi-detector gated cardiac computed tomography (CCT) allows three-dimensional (3D) quantification of cardiac chambers and is clinically indicated to assess left ventricular assist device (LVAD) malfunction and complications. Automated volumetric analysis is, however, disrupted by inflow cannula artifact in patients with LVAD. With this study, we evaluated intra-observer variability in semi-automated 3D cardiac volumetric analysis using CCT in patients with LVADs. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.01.024DOI Listing
January 2019

Characteristics Associated With Mortality in 372 Patients Receiving Low-Dose Recombinant Factor VIIa (rFVIIa) for Cardiac Surgical Bleeding.

J Cardiothorac Vasc Anesth 2019 Jan 22. Epub 2019 Jan 22.

Department of Anesthesiology, Division of Critical Care, Kansas University Medical Center, Kansas City, KS. Electronic address:

Objective: Activated recombinant factor VII (rFVIIa) has been used to treat cardiac surgical bleeding in an off-label manner. This observational report analyzes the outcomes with use of a low dose and early administration of rFVIIa for cardiac surgical bleeding.

Design: A retrospective, observational study. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.047DOI Listing
January 2019

Prevalence and Clinical Impact of Systemic Inflammatory Reaction After Cardiac Surgery.

J Cardiothorac Vasc Anesth 2019 Jan 17. Epub 2019 Jan 17.

Department of Emergency and Organ Transplant, University of Bari Aldo Moro, Italy; Santa Maria Hospital, Department of Cardiac Surgery, GVM Care & Research, Bari, Italy. Electronic address:

Objectives: Cardiac surgery induces a systemic inflammatory reaction that has been associated with postoperative mortality and morbidity. Many studies have characterized this reaction through laboratory biomarkers while clinical studies generally are lacking. This study aimed to assess the incidence of postoperative systemic inflammation after cardiac surgery, and the association of postoperative systemic inflammation with preoperative patients' characteristics and postoperative outcomes. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.043DOI Listing
January 2019

Comments on: "A Meta-Analysis of the Association between Microrna-196A2 and Risk of Ischemic Stroke and Coronary Artery Disease in Asian Population".

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.014DOI Listing
February 2019

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Orolingual angioedema (OLAE) is a rare adverse effect of alteplase. Previous studies have associated the occurrence of OLAE with thrombolysed patients maintained on angiotensin converting enzyme inhibitors. We report a case of a 60-year-old male presenting with hyperacute ischemic stroke developing hemilingual edema after thrombolysis. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.030DOI Listing
February 2019

Widening Time Disparities between Two Paradigms: Tama-REgistry of Acute Endovascular Thrombectomy.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Stroke and Cerebrovascular Medicine, Kyorin University, Tokyo, Japan. Electronic address:

Background: The Tama-REgistry of Acute endovascular Thrombectomy (TREAT) is a multicenter registry of endovascular thrombectomy in the Tama area of Tokyo. The objective of this study was to confirm the real-world status of 2 paradigms of transportation.

Methods: This was a retrospective analysis of data from TREAT. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.021DOI Listing
February 2019

Deep Venous Thrombosis with Decreased Cerebral Blood Flow to the Thalamus was Completely Restored by Factor Xa Inhibitor.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Kanazawa Medical Center, Kanazawa, Japan.

Background: Cerebral venous thrombosis is rare and an uncommon cause of stroke and has diverse etiologies and varied clinical presentations. Here, we report 2 cases of deep cerebral venous thrombosis.

Case Description: A 64-year-old woman presented with cerebral venous thrombosis due to a hypercoagulable state associated with ovarian tumor. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.023DOI Listing
February 2019

Efficacy of Direct Revascularization Surgery for Hemorrhagic Moyamoya Syndrome As a Late Complication of Cranial Irradiation for Childhood Craniopharyngioma.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Tohoku University, Sendai, Japan.

Moyamoya syndrome (MMS) is an uncommon late complication after cranial irradiation. Its hemorrhagic presentation from the associated pseudo-aneurysm is extremely rare, and the optimal management strategy is undetermined. We herein report a 36-year-old man who developed intraventricular hemorrhage from a pseudo-aneurysm at the extended left anterior choroidal artery as an abnormal collateral of MMS 30 years after surgical removal and cranial irradiation for childhood craniopharyngioma. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.033DOI Listing
February 2019

Etiologic Evaluation of Ischemic Stroke in Young Adults: A Comparative Study between Two European Centers.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal; Department of Neurosciences and Mental Health, Service of Neurology, Hospital Santa Maria-CHLN, Universidade de Lisboa, Lisboa, Portugal.

Introduction: Identifying the cause of ischemic stroke in young adults is often difficult. Our objective was to compare the etiologic diagnostic strategy for ischemic stroke in young adults between 2 European centers and investigate the influence of workup variations in the diagnosed etiologies.

Patients And Methods: We included patients aged 18-55 years admitted for ischemic stroke or transient ischemic attack to the stroke units of Santa Maria Hospital in Lisbon, Portugal, and Innsbruck University Hospital in Innsbruck, Austria, between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.019DOI Listing
February 2019

Direct Aspiration versus Stent Retriever Thrombectomy for Acute Stroke: A Systematic Review and Meta-Analysis in 9127 Patients.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, University of South Florida, Tampa, Florida. Electronic address:

Background: The two most common approaches to thrombectomy of emergent large vessel occlusion (direct aspiration and primary stent retriever thrombectomy) have been extensively studied; however, the detailed benefit and risk comparison is largely unknown.

Objective: To conduct a systematic review and meta-analysis to compare radiographic and clinical outcomes between the use of primary stent retrievers and direct aspiration in management of acute ischemic stroke.

Methods: PubMed database was searched for studies between September 1, 2012 and December 31, 2017 with acute ischemic stroke patients. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.034DOI Listing
February 2019

Self-Reported Body Weight Changes, Perceptions, and Weight Loss Techniques among Stroke Survivors.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

VARRD Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Atlanta, Georgia; Emory University, School of Medicine, Atlanta, Georgia. Electronic address:

Background: Little is known about the body weight goals and trends of stroke survivors, despite evidence that overweight and obesity can negatively influence poststroke rehabilitation outcomes. Thus, the purpose of this study was to identify self-reported body weight trends over time in stroke survivors and nonstroke controls (>50 years old) and describe the methods used to attempt to achieve body weight goals.

Methods: Self-reported body weight 1) at age 25 years, 2) 10 years prior to the current assessment, 3) 1 year prior to the current assessment, 4) current weight, and 5) age of heaviest body weight were collected from adults self-reporting a stroke in the 2011-2012 and 2013-2014 National Health and Nutrition Examination Surveys (stroke: N = 387 and nonstroke: N = 5085). Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.028DOI Listing
February 2019

Association between Mapuche Ethnicity and Stroke: A Case-Control Study.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Center for Research in Cardiovascular and Nutritional Epidemiology (EPICYN), Universidad de La Frontera, Temuco, Chile; Department of Public Health, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile; Center of Excellence CIGES, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.

Background: There is evidence of a greater incidence of stroke in native populations and minorities. A total of 34% of the population in the Araucanía Region is indigenous. The association between Mapuche ethnicity and stroke is unknown. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.029DOI Listing
February 2019

Preclinical Carotid Atherosclerosis in Patients With Juvenile-Onset Mixed Connective Tissue Disease.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. Electronic address:

Background: This study investigated preclinical atherosclerosis in patients with juvenile mixed connective tissue disease (JMCTD), which is a chronic inflammatory disease with a varied phenotype. Mixed connective tissue disease (MCTD) has well known associations with other autoimmune diseases known to have increased risk of cardiovascular disease. However, the cardiovascular risk for patients with the juvenile form remains unclear. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.027DOI Listing
February 2019

Change in body mass index from childhood onwards and risk of adult cardiovascular disease.

Trends Cardiovasc Med 2019 Feb 5. Epub 2019 Feb 5.

Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Denmark.

Childhood obesity adversely affects the structure and function of the cardiovascular system, but the relationship between excessive weight gain during childhood and adult cardiovascular disease (CVD) is not fully understood. This review summarizes evidence for associations of change in body mass index (BMI) from childhood onwards with CVD outcomes. We found that excessive gain in BMI from childhood onwards was consistently associated with the presence of CVD risk factors, with increased risks of coronary heart disease, and there were suggestions of associations with stroke, atrial fibrillation and heart failure, but a lack of evidence precludes firm conclusions. Read More

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http://dx.doi.org/10.1016/j.tcm.2019.01.011DOI Listing
February 2019

Strategies for glycemic control in nonobese and obese type 2 diabetic patients with coronary artery disease.

Int J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan.

Background: This study aimed to assess strategies of insulin-providing (IP) or insulin-sensitizing (IS) therapy for glycemic control in nonobese diabetic patients with coronary artery disease (CAD) with possibly higher cardiovascular risk and lower insulin secretion than obese diabetic patients with CAD.

Methods: We used data from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial to calculate hazard ratio (HR) with 95% confidence interval (95%CI) for outcome events in patients with type 2 diabetes and CAD using Cox proportional hazard models. The comparison between the IP and IS groups was performed using the randomized design of the BARI 2D trial separately for nonobese (n = 1021) and obese (n = 1319) patients. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.008DOI Listing
February 2019

Anticoagulation for atrial fibrillation in patients with active cancer.

Int J Cardiol 2019 Apr;280:98

Lymphoid Malignancies Branch, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.ijcard.2018.11.003DOI Listing

Sex Differences in Risk Factors for Incident Atrial Fibrillation (from the Reasons for Geographic and Racial Differences in Stroke [REGARDS] Study).

Am J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina; Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina. Electronic address:

We examined whether the sex differences in atrial fibrillation (AF) is related to difference in risk factors leading to AF or due to a differential impact of the same risk factors in 11,806 participants (55.2 % women) from the REGARDS study. Incident AF was ascertained by electrocardiograms and medical history at a follow-up examination. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.056DOI Listing
February 2019

dl-3-n-butylphthalide for alleviation of neurological deficit after combined extracranial-intracranial revascularization for moyamoya disease: a propensity score-matched analysis.

J Neurosurg 2019 Feb 15:1-13. Epub 2019 Feb 15.

1Department of Neurosurgery, Peking University International Hospital.

OBJECTIVEPostoperative neurological deficits impair the overall outcome of revascularization surgery for patients with moyamoya disease (MMD). dl-3-n-butylphthalide (NBP) is approved for the treatment of ischemic stroke in China. This pilot study evaluated the effect of NBP on perioperative stroke and neurological deficits in patients with MMD. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182152DOI Listing
February 2019

Differences between flexion and extension synergy-driven coupling at the elbow, wrist, and fingers of individuals with chronic hemiparetic stroke.

Clin Neurophysiol 2019 Jan 31;130(4):454-468. Epub 2019 Jan 31.

Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA; Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Objective: The flexion and extension synergies were quantified at the paretic elbow, forearm, wrist, and finger joints within the same group of participants for the first time. Differences in synergy expression at each of the four joints were examined, as were the ways these differences varied across the joints.

Methods: Twelve post-stroke individuals with chronic moderate-to-severe hemiparesis and six age-matched controls participated. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.010DOI Listing
January 2019

Trial of intrathecal rituximab in progressive multiple sclerosis patients with evidence of leptomeningeal contrast enhancement.

Mult Scler Relat Disord 2019 Feb 11;30:136-140. Epub 2019 Feb 11.

Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 627, Baltimore, MD 21287, USA.

Background: Leptomeningeal inflammation is associated with increased cortical damage and worse clinical outcomes in MS. It may be detected on contrast-enhanced T2-FLAIR imaging as focal leptomeningeal contrast-enhancement (LME).

Objective: To assess the safety of intrathecal (IT) rituximab in progressive MS (PMS) and to assess its effects on LME and CSF biomarkers. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.013DOI Listing
February 2019

Stroke occurrence while on antiplatelet therapy may predict atrial fibrillation detected after stroke.

Atherosclerosis 2019 Jan 24;283:13-18. Epub 2019 Jan 24.

Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan; Department of Information Management and Institute of Healthcare Information Management, National Chung Cheng University, Chiayi County, Taiwan. Electronic address:

Background And Aims: Stroke occurrence while on antiplatelet therapy, i.e., a breakthrough stroke, is often conveniently attributed to antiplatelet resistance. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.007DOI Listing
January 2019

Evaluation of the sensitivity of Rρ MRI to pH and macromolecular density.

Magn Reson Imaging 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address:

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.004DOI Listing
February 2019

Mechanical thrombectomy of M2 occlusions with distal access catheters using ADAPT.

J Neuroradiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Diagnostic and Interventional Neuroradiology, Medical School Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany; Department of Interventional Neuroradiology, Johanna-Etienne-Hospital, Am Hasenberg 46, D-41462 Neuss, Germany.

Background And Purpose: The direct aspiration first pass technique (ADAPT) using distal access catheters (DAC) has proven to be an effective and safe endovascular treatment strategy of acute ischemic stroke with large vessel occlusions (LVO). However, data about direct aspiration using DAC in M2 segment occlusions is limited. We assess the safety and efficacy of DACs in acute M2 occlusions using ADAPT with large bore (5 French /6 French) aspiration catheters as the primary method for endovascular recanalization. Read More

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http://dx.doi.org/10.1016/j.neurad.2019.01.096DOI Listing
February 2019

Longitudinal Study of Peripapillary Thinning in Sickle Cell Hemoglobinopathies.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL. Electronic address:

Purpose: To determine the rate of retinal nerve fiber layer (RNFL) thinning in patients with sickle cell hemoglobinopathies. Design; Prospective cohort study METHODS: Sixty-seven patients averaging 35.8±11. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.006DOI Listing
February 2019

Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency Intensive Care Unit, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, 108 Wansong Road, Ruian 325200, Zhejiang Province, China.

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is currently known as an acute phase protein and implicated in acute brain injury. Herein, we sought to gauge serum NGAL level in patients after acute (<24 h) spontaneous intracerebral hemorrhage (ICH) and to investigate its relation to neurological outcome.

Methods: Serum NGAL levels were measured in 106 patients and 106 controls. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.009DOI Listing
February 2019

Frailty score for elderly patients is associated with short-term clinical outcomes in patients with ST-segment elevated myocardial infarction treated with primary percutaneous coronary intervention.

Neth Heart J 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.

Objective: Consistent with the aging population in the Western world, there is a growing number of elderly patients with ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) is the recommended reperfusion strategy in elderly patients; risk models to determine which of these patients are prone to have poor clinical outcomes are, however, essential. The purpose of this study was to assess the association between frailty and short-term mortality and PCI-related serious adverse events (SAE) in elderly patients. Read More

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http://dx.doi.org/10.1007/s12471-019-1240-7DOI Listing
February 2019

Uptake in antithrombotic treatment and its association with stroke incidence in atrial fibrillation: insights from a large German claims database.

Clin Res Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiology, Ludwig-Maximilians-University, Munich, Germany.

Background: Underuse of oral anticoagulation (OAC) for stroke prevention in atrial fibrillation (AF) results in thousands of preventable strokes in Germany each year. This study aimed to assess changes in antithrombotic therapy in AF patients after increased use of direct oral anticoagulants (DOACs) in Germany and to evaluate whether the adoption of DOAC therapy was associated with changes in AF-related stroke and bleeding over time.

Methods: Analyses were carried out on a large claims-based dataset of 4 million health-insured Germans. Read More

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http://dx.doi.org/10.1007/s00392-019-01437-7DOI Listing
February 2019

Endovascular therapy for acute ischemic stroke: which role for neurologists?

Neurol Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Behavioural and Clinical Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina, 306, Rome, Italy.

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http://dx.doi.org/10.1007/s10072-019-03759-wDOI Listing
February 2019

Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea.

Lung 2019 Feb 15. Epub 2019 Feb 15.

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.

Background: Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. Read More

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http://dx.doi.org/10.1007/s00408-019-00205-8DOI Listing
February 2019

A "one-stop-shop" 4D CTA protocol using 320-row CT for advanced imaging in acute ischemic stroke: a technical note.

Eur Radiol 2019 Feb 15. Epub 2019 Feb 15.

Service d'Imagerie Médicale, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609, Brest Cedex, France.

This technical note describes a novel CT scan protocol that includes a non-enhanced CT, dynamic CTA, and perfusion of the whole brain and CTA of the carotid arteries using a 320-row area detector CT scanner, with a unique contrast injection and acceptable radiation exposure dose in patients presenting with acute ischemic stroke. The acquisition parameters and reconstruction parameters will be discussed including the use of model-based iterative reconstruction (MBIR), time summing (tMIP), and subtraction techniques to optimize the results of this protocol.Key Points• Scanning on a 320-row area detector CT can achieve both brain perfusion with dynamic angiography and reconstructed arterial and venous CTA, and supra aortic trunk angiography, in a single acquisition. Read More

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http://dx.doi.org/10.1007/s00330-019-06041-xDOI Listing
February 2019

Foetal radiation exposure caused by mechanical thrombectomy in large-vessel ischaemic stroke in pregnancy.

Neuroradiology 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuroradiology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.

Purpose: There is overwhelming evidence for the clinical benefits that are derived following mechanical thrombectomy in large-vessel acute ischaemic stroke. The risk of stroke is elevated in pregnancy due to many factors. To date, there have been two reports, totalling five patients, who have undergone mechanical thrombectomy in pregnancy, thus demonstrating the feasibility of the procedure; however, there is no data on the radiation exposure to the mother or foetus related to this therapy. Read More

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http://dx.doi.org/10.1007/s00234-019-02163-7DOI Listing
February 2019

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 Feb 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019

Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.

Lab Invest 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Accumulation of abnormal tau in neurofibrillary tangles (NFT) occurs in Alzheimer disease (AD) and a spectrum of tauopathies. These tauopathies have diverse and overlapping morphological phenotypes that obscure classification and quantitative assessments. Recently, powerful machine learning-based approaches have emerged, allowing the recognition and quantification of pathological changes from digital images. Read More

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http://dx.doi.org/10.1038/s41374-019-0202-4DOI Listing
February 2019

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Nat Commun 2019 Feb 15;10(1):797. Epub 2019 Feb 15.

Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, 28029, Madrid, Spain.

FXR1 is an alternatively spliced gene that encodes RNA binding proteins (FXR1P) involved in muscle development. In contrast to other tissues, cardiac and skeletal muscle express two FXR1P isoforms that incorporate an additional exon-15. We report that recessive mutations in this particular exon of FXR1 cause congenital multi-minicore myopathy in humans and mice. Read More

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http://dx.doi.org/10.1038/s41467-019-08548-9DOI Listing
February 2019

Social determinants and cardiovascular disease mortality in Panama, 2012-2016.

BMC Public Health 2019 Feb 15;19(1):199. Epub 2019 Feb 15.

Gorgas Memorial Institute for Health Studies, Panama City, Panama.

Background: The aims of this study were to determine the geographic and time variation of social determinants of health (SDH) and cardiovascular disease (CVD) mortality in Panama from 2012 to 2016, and to identify which of the SDH has the strongest correlation with a socioeconomic index (SEI).

Methods: We conducted an ecological study obtaining mortality from the National Mortality Register and socioeconomic variables derived from the National Household Survey (NHS). The International Classification of Diseases 10th revision codes I20-I25 and I60-I69 were used for ischemic heart disease (IHD) and stroke, respectively. Read More

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http://dx.doi.org/10.1186/s12889-019-6508-8DOI Listing
February 2019

EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC.

J Exp Clin Cancer Res 2019 Feb 15;38(1):83. Epub 2019 Feb 15.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

Background: The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels and cause effective anti-tumor effects in diverse human cancers. However, its cytotoxic effect and related mechanisms of drug resistance are poorly understood in hepatocellular carcinomas (HCC). Read More

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http://dx.doi.org/10.1186/s13046-019-1082-6DOI Listing
February 2019