310,052 results match your criteria Stroke; a journal of cerebral circulation[Journal]


Head and Neck Pain in Patients Presenting with Acute Aortic Dissection.

Aorta (Stamford) 2018 Dec 24;6(6):130-138. Epub 2019 Apr 24.

Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.

Background:  Head and neck pain is an atypical presentation of acute aortic dissection. Classic teaching associates this pain with proximal dissections, but this has not been extensively studied.

Methods:  Patients enrolled in the International Registry of Acute Aortic Dissection from January 1996 to March 2015 were included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-18388DOI Listing
December 2018

Single Low-Volume Center Experience with Frozen Elephant Trunk in Acute Type A Aortic Dissections.

Aorta (Stamford) 2018 Dec 24;6(6):125-129. Epub 2019 Apr 24.

Department of Cardiac Surgery, Virgen de la Salud Hospital, Toledo, Spain.

Background:  Acute Type A aortic dissection (AAAD) is a surgical emergency. In patients with arch and descending aorta involvement (DeBakey Type I), a total aortic arch replacement with frozen elephant trunk (FET) could favor false lumen thrombosis and improve long-term results. The authors hereby present their experience with this technique in a single low-volume center, to assess whether the technique is feasible to treat such disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677809DOI Listing
December 2018

Associations between self-generated strategy use and MET-Home performance in adults with stroke.

Neuropsychol Rehabil 2019 Apr 24:1-15. Epub 2019 Apr 24.

e School of Occupational Therapy , Texas Woman's University , Dallas , TX , USA.

Self-generated strategy use has substantial potential for improving community living outcomes in adults with impaired executive function after stroke. However, little is known about how self-generated strategies support task performance in people with post-stroke executive function impairments living in the community. We explored strategy use among home-dwelling persons with stroke and neurologically-healthy control participants during the Multiple Errands Test-Home Version (MET-Home), a context-specific assessment with evidence of ecological validity designed to examine how post-stroke executive dysfunction manifests during task performance in the home environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09602011.2019.1601112DOI Listing

Home as a Place for Care of the Oldest Stroke Patients: A Pilot from the Catalan Stroke Program.

J Am Geriatr Soc 2019 Apr 24. Epub 2019 Apr 24.

Stroke Program, Ministry of Health of Catalonia, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgs.15944DOI Listing

Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia.

PLoS One 2019 24;14(4):e0216162. Epub 2019 Apr 24.

Department of Medical and Surgical Sciences and Advanced Technology, Section of Neurosciences, University of Catania, Catania, Italy.

Background: Although cerebral white matter lesions (WMLs) are considered as a risk factor for vascular dementia, data on their impact on cerebral hemodynamics are scarce. We test and compare transcranial Doppler (TCD) features in WML patients with or without associated cognitive impairment.

Methods: A sample of non-demented elderly patients with WMLs was consecutively recruited. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216162PLOS

Prolonged time course of population excitatory postsynaptic potentials in motoneurons of chronic stroke survivors.

J Neurophysiol 2019 Apr 24. Epub 2019 Apr 24.

research, Northwestern University, United States.

Hyperexcitability of spinal motoneurons may contribute to muscular hypertonia after hemispheric stroke. The origins of this hyperexcitability are not clear, but we hypothesized that prolongation of the Ia excitatory postsynaptic potential (EPSP) in spastic motoneurons may be one potential mechanism, by enabling more effective temporal summation of Ia EPSPs, making action potential initiation easier. Thus, the purpose of this study is to quantify the time-course of putative EPSPs in spinal motoneurons of chronic stroke survivors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00288.2018DOI Listing

Analysis of States' Barriers to and Progress Toward Implementation of Health and Safety Policies for Secondary School Athletics.

J Athl Train 2019 Apr 24. Epub 2019 Apr 24.

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs.

Context: Implementation of health and safety best practices for the leading causes of sudden death and catastrophic injury has been shown to mitigate risk. However, to our knowledge, no authors have examined progress toward health and safety policy implementation at the state level.

Objective: To investigate the progress made by state secondary school leaders in developing and implementing health and safety policies (ie, exertional heat stroke, sudden cardiac arrest, concussion, emergency action plans) and to explore perceived barriers to and strategies for implementation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4085/1062-6050-28-18DOI Listing

Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Universite de Lorraine, INSERM Unite 1116, Vandoeuvre les Nancy, France.

Importance: Whether anticoagulation benefits patients with heart failure (HF) in sinus rhythm is uncertain. The COMMANDER HF randomized clinical trial evaluated the effects of adding low-dose rivaroxaban to antiplatelet therapy in patients with recent worsening of chronic HF with reduced ejection fraction, coronary artery disease (CAD), and sinus rhythm. Although the primary end point of all-cause mortality, myocardial infarction, or stroke did not differ between rivaroxaban and placebo, there were numerical advantages favoring rivaroxaban for myocardial infarction and stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamacardio.2019.1049DOI Listing

Sir Winston Churchill KG: fracture of fifth thoracic vertebra and a stroke following a fall on 15 November 1960.

J R Soc Med 2019 Apr 24:141076819843655. Epub 2019 Apr 24.

3 National Hospital for Neurology & Neurosurgery, London WC1N 3BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0141076819843655DOI Listing

Pentraxin-3 vs C-reactive protein and other prognostic biomarkers in acute coronary syndrome: A substudy of the Platelet Inhibition and Patients Outcomes (PLATO) trial.

Eur Heart J Acute Cardiovasc Care 2019 Apr 24:2048872619846334. Epub 2019 Apr 24.

7 Department of Medical Sciences, Cardiology Uppsala University, Sweden.

Aims: We investigated the dynamics, associations with patient characteristics, other biomarkers, and clinical outcomes of pentraxin 3 in acute coronary syndrome.

Methods And Results: In multivariate analyses, pentraxin 3 measured in 5154 patients randomised in the Platelet Inhibition and Patients Outcomes (PLATO) trial (NCT00391872) was compared with leukocytes, high-sensitivity C-reactive protein, interleukin-6, cystatin C, N-terminal prohormone brain natriuretic peptide, high-sensitivity troponin T and growth differentiation factor 15 concerning prediction of clinical outcome. Pentraxin 3 peaked earlier than high-sensitivity C-reactive protein and was more strongly correlated with N-terminal prohormone brain natriuretic peptide and high-sensitivity troponin T than with high-sensitivity C-reactive protein. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2048872619846334DOI Listing

Secondary prevention after stroke/transient ischemic attack, a randomized audit&feedback trial.

Acta Neurol Scand 2019 Apr 24. Epub 2019 Apr 24.

Karolinska Institutet Stroke Research Network at Södersjukhuset, Sweden.

Objectives: The clinical benefits of use of secondary preventive pharmacotherapy in ischemic stroke/TIA have been previously demonstrated. A potential target for facilitating use of recommended medication is primary care physicians. Therefore, we carried out an audit&feedback intervention aimed at primary care centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13109DOI Listing

Identification of key transcription factors associated with cerebral ischemia‑reperfusion injury based on gene‑set enrichment analysis.

Int J Mol Med 2019 Jun 9;43(6):2429-2439. Epub 2019 Apr 9.

Department of Vascular Neurosurgery, New Era Stroke Care and Research Institute, The PLA Rocket Force Characteristic Medical Center, Beijing 100088, P.R. China.

Cerebral ischemia‑reperfusion injury (CIRI) usually causes detrimental complications following reperfusion therapy in stroke patients. The present study systematically investigated the regulatory mechanism involved in the pathogenesis of CIRI using gene set enrichment analysis of the transient middle cerebral artery occlusion mouse stroke model. The results revealed a total of 13 CIRI‑related transcription factors (TFs), including CCAAT enhancer binding protein b (Cebpb), Cebpa, early growth response‑1, Fos, Rela, Jund, signal transduction and activator of transcription 5a/b, transformation related protein 53, GLI family zinc finger 2 (Gli2), Sp3, TF AP‑2 α (Tfap2a) and spleen focus forming virus proviral integration oncogene (Spi1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijmm.2019.4159DOI Listing

Effectiveness of the Bobath concept in the treatment of stroke: a systematic review.

Disabil Rehabil 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing , Physiotherapy and Podiatry, Complutense University of Madrid , Madrid , Spain.

Purpose: To evaluate the effectiveness of the Bobath concept in sensorimotor rehabilitation after stroke.

Materials And Methods: A systematic literature review was conducted on the Bobath concept from the first publication available to January 2018, consulting PUBMED, CENTRAL, CINAHL and PEDro databases. Fifteen clinical trials were selected in two consecutive screenings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09638288.2019.1590865DOI Listing

Effect of Warfarin on Ischemic Stroke, Bleeding, and Mortality in Patients with Atrial Fibrillation Receiving Peritoneal Dialysis.

Am J Cardiovasc Drugs 2019 Apr 23. Epub 2019 Apr 23.

Division of Cardiology, Kaiser Permanente Los Angeles Medical Center, 1526 North Edgemont Street, 2nd Floor, Los Angeles, CA, 90027, USA.

Background: There is limited information on the risks and benefits of anticoagulation in patients with atrial fibrillation receiving peritoneal dialysis.

Objective: The aim was to determine the risk of mortality, ischemic stroke, and bleeding associated with warfarin use in patients with atrial fibrillation receiving peritoneal dialysis.

Patients And Methods: This is a retrospective observational study of a multi-ethnic cohort of patients with atrial fibrillation receiving peritoneal dialysis in the United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40256-019-00347-3DOI Listing

Serum Alkaline Phosphatase Level is Associated with Angiographic Vasospasm, Delayed Cerebral Ischemia-Caused Clinical Deterioration, and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.

Neurocrit Care 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang Province, China.

Background: Alkaline phosphatase (ALP) has been implicated to be associated with poor outcome in ischemic stroke patients, yet its role in aneurysmal subarachnoid hemorrhage (aSAH) patients is unknown. The current study aimed to investigate the on-admission and short-term variation trend of ALP levels in aSAH patients as well as its associations with vasospasm, delayed cerebral ischemia (DCI), and outcome after aSAH.

Methods: Between January 2014 and May 2018, all consecutive aSAH patients were prospectively enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12028-019-00714-7DOI Listing

HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein.

J Neurovirol 2019 Apr 23. Epub 2019 Apr 23.

Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10; Room 7C-103, 10 Center Drive, Bethesda, MD, 20892, USA.

In patients infected with the human immunodeficiency virus (HIV), the HIV-Tat protein may be continually produced despite adequate antiretroviral therapy. As the HIV-infected population is aging, it is becoming increasingly important to understand how HIV-Tat may interact with proteins such as amyloid β and Tau which accumulate in the aging brain and eventually result in Alzheimer's disease. In this review, we examine the in vivo data from HIV-infected patients and animal models and the in vitro experiments that show how protein complexes between HIV-Tat and amyloid β occur through novel protein-protein interactions and how HIV-Tat may influence the pathways for amyloid β production, degradation, phagocytosis, and transport. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13365-019-00736-zDOI Listing

Effects of Ticagrelor versus Clopidogrel in Patients with Coronary Bifurcation Lesions Undergoing Percutaneous Coronary Intervention.

Biomed Res Int 2019 20;2019:3170957. Epub 2019 Mar 20.

Department of Cardiology, Xinqiao Hospital, Army Medical University, Third Military Medical University, Chongqing 400037, China.

Background: Percutaneous treatment of coronary bifurcation lesions can potentially lead to higher risk of ischemic events than the nonbifurcation ones, thus calling for further optimization of dual antiplatelet therapy (DAPT). This study aimed to compare the clinical outcomes from ticagrelor and clopidogrel in bifurcation lesions patients undergoing percutaneous coronary intervention (PCI).

Methods: We performed a retrospective cohort study in patients with coronary bifurcation lesions. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/bmri/2019/3170957/
Publisher Site
http://dx.doi.org/10.1155/2019/3170957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448338PMC
March 2019
1 Read

Outcomes of Inpatient Versus Outpatient Elective Foot and Ankle Surgery.

Cureus 2019 Feb 12;11(2):e4058. Epub 2019 Feb 12.

Orthopaedics, University of Alabama School of Medicine, Birmingham, USA.

Background Complications following orthopedic surgeries are undesirable and costly. A potential method to reduce these costs is to perform traditionally inpatient surgical procedures in the outpatient setting. The purpose of this study is to compare outcomes between inpatient and outpatient settings for elective foot and ankle surgeries using the National Surgical Quality Improvement Program (NSQIP) database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.4058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464278PMC
February 2019

Balloon-assisted Tracking of Guide Extension Catheter: A Novel Technique to Retrieve a Carotid Embolic Protection Device.

Cureus 2019 Feb 11;11(2):e4045. Epub 2019 Feb 11.

Cardiology, Kingman Regional Medical Center, Kingman, USA.

Embolic protection devices are used to minimize the risk of stroke by preventing the migration of emboli during carotid artery stenting (CAS). After the successful conclusion of the CAS procedure, these devices are meant to be retrieved. Sometimes retrieval of the filter can be difficult. Read More

View Article

Download full-text PDF

Source
https://www.cureus.com/articles/17408-balloon-assisted-track
Publisher Site
http://dx.doi.org/10.7759/cureus.4045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464459PMC
February 2019
1 Read

Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease.

Sci Rep 2019 Apr 23;9(1):6432. Epub 2019 Apr 23.

MP3CV, EA7517, CURS, Jules Verne University of Picardie, Amiens, 80025, France.

Ischemic stroke is highly prevalent in chronic kidney disease (CKD) patients and has been associated with a higher risk of neurological deterioration and in-hospital mortality. To date, little is known about the processes by which CKD worsens ischemic stroke. This work aimed to investigate the cellular and molecular mechanism associated with ischemic stroke severity in an in vivo model of CKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42933-0DOI Listing

Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews.

BMJ Open 2019 Apr 23;9(4):e023085. Epub 2019 Apr 23.

HRB Centre for Primary Care Research and Department of General Practice, Royal College of Surgeons in Ireland, Dublin, Ireland.

Objective: To synthesise evidence from exclusively primary prevention data on the effectiveness of statins for prevention of cardiovascular disease (CVD), including stroke, and outcomes stratified by baseline risk and gender.

Design: Overview of systematic reviews (SRs) using Revised-AMSTAR approach to assess quality.

Data Sources: Cochrane Database of Systematic Reviews, MEDLINE, Embase, PubMed, Scopus and PROSPERO to June 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023085DOI Listing

Thromboembolic and haemorrhagic events in patients with atrial fibrillation: a prospective cohort study in UK primary and secondary care.

Br J Gen Pract 2019 Apr 23. Epub 2019 Apr 23.

Barts, and the London School of Medicine and Dentistry, Queen Mary University of London, London; research fellow, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge.

Background: Strong evidence on the long-term safety and efficacy of different types of anticoagulants would help clinicians to prevent thromboembolic events among patients with atrial fibrillation (AF) while minimising the risk of haemorrhages.

Aim: To estimate the risk of thromboembolic and haemorrhagic events for patients with AF on antiplatelets or anticoagulants.

Design And Setting: This was a cohort study using routinely collected UK primary and secondary care clinical data from patients with AF, aged ≥18 years, and with an indication to receive anticoagulation before April 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3399/bjgp19X702269DOI Listing

Far-field contributions in multi-electrodes atrial recordings blur distinction between anatomical and functional reentries and may cause imaginary phase singularities - A computational study.

Comput Biol Med 2019 Mar 14;108:276-287. Epub 2019 Mar 14.

Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and the most important cause of embolic stroke, requiring new technologies for its better understanding and therapies. Recent approaches to map the electrical activity during AF with multi-electrode systems aim at localizing patient-specific ablation targets of reentrant patterns. However, there is a critical need to determine the accuracy of those mapping systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2019.02.022DOI Listing

Apixaban for prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation in France: The PAROS cross-sectional study of routine clinical practice.

Arch Cardiovasc Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Cardiology, Hôpital Bichat, AP-HP, 75018 Paris, France; Inserm U1148, Université Paris Diderot, 75877 Paris, France. Electronic address:

Background: Non-vitamin K antagonist oral anticoagulants (NOACs), including apixaban, are recommended for prevention of stroke and systemic embolism in non-valvular atrial fibrillation (NVAF).

Aims: To describe the characteristics of patients starting anticoagulant treatment, identify the characteristics associated with apixaban prescription, and describe apixaban use in France.

Methods: This was a non-interventional multicentre French study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18752136193007
Publisher Site
http://dx.doi.org/10.1016/j.acvd.2019.02.003DOI Listing
April 2019
1 Read

A troponin study on patients with ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage: Type II myocardial infarction is significantly associated with stroke severity, discharge disposition and mortality.

J Clin Neurosci 2019 Apr 20. Epub 2019 Apr 20.

University Hospitals Cleveland Medical Center, Cleveland, OH, United States. Electronic address:

Troponin elevations due to Type II myocardial infarction (T2MI) are associated with hemorrhagic and ischemic strokes but there is little data on stroke severity, troponin elevation and outcome. We studied 1655 patients from a tertiary medical center between 1/2013-4/2015 using multivariate regression analysis for demographics, vascular risk factors, admission stroke severity, laboratory tests, echocardiogram results and discharge disposition. Troponin levels were classified as normal <0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2019.04.005DOI Listing

Trends and outcomes of red blood cell transfusion in patients undergoing transcatheter aortic valve replacement in the United States.

J Thorac Cardiovasc Surg 2019 Mar 28. Epub 2019 Mar 28.

The Warren Alpert Medical School of Brown University, Providence, RI; Lifespan Cardiovascular Institute, Providence, RI. Electronic address:

Objectives: To examine temporal trends, predictors, and outcomes of red blood cell (RBC) transfusion in patients undergoing transcatheter aortic valve replacement (TAVR) in the United States.

Methods: We used the National Inpatient Sample databases to identify TAVR procedures performed between January 2012 and September 2015 in the United States. Patients were propensity matched (within the strata of overt and no bleeding) on the likelihood of receiving RBC transfusion, and in-hospital outcomes were compared between the 2 groups in the matched cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtcvs.2019.03.043DOI Listing

Incidence and Cost of Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients With Chronic Coronary Artery Disease or Peripheral Artery Disease.

Am J Cardiol 2019 Mar 16. Epub 2019 Mar 16.

Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York, New York.

Chronic coronary artery disease (CAD) and peripheral artery disease (PAD) are both associated with elevated risks of major adverse cardiovascular events (MACE) and major adverse limb events (MALE). The frequency of these events in patients with CAD or PAD, and their corresponding costs, are not well understood. Accordingly, we describe the incidence and cost of both MACE and MALE in patients with CAD or PAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjcard.2019.03.022DOI Listing

Ischemic stroke risk estimation in patients without oral anticoagulation: an observational cohort study based on secondary data from Germany.

BMC Cardiovasc Disord 2019 Apr 23;19(1):94. Epub 2019 Apr 23.

Institute of General Practice, Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Background: Oral anticoagulants can cause potentially serious adverse events. Therefore, before prescribing oral anticoagulants for ischemic stroke prevention in patients with atrial fibrillation (AF), stroke risk assessment is required to identify patients that are likely to benefit from treatment. Current guidelines recommend the CHADS-VASc-score for stroke risk assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12872-019-1074-7DOI Listing

Hemoglobin A1c and 10-year information processing speed in Japanese community dwellers.

Environ Health Prev Med 2019 Apr 23;24(1):24. Epub 2019 Apr 23.

Section of NILS-LSA, National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi, 474-8511, Japan.

Background: Hyperglycemia is believed to be a risk factor for cognitive decline, but the longitudinal relationship between hyperglycemia and cognitive decline in the Japanese population is unclear. The present study aimed to clarify the association between blood glucose levels and information processing ability in middle-aged and older adults.

Methods: The subjects were 866 men and 815 women aged 40-79 years not taking medication for diabetes who participated in the first study wave (1997-2000) and then participated at least once in the subsequent six study waves (2000-2012) of the National Institute for Longevity Sciences-Longitudinal Study of Aging, Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12199-019-0778-8DOI Listing

A Very Rare Case of Coronary Artery Bypass Grafting in a Progeria Child.

World J Pediatr Congenit Heart Surg 2019 Apr 23:2150135118803596. Epub 2019 Apr 23.

1 Cardiothoracic Surgery Department, Hospital de Santa Marta-Centro Hospitalar Lisboa Central, Lisbon, Portugal.

Hutchinson-Gilford progeria syndrome is a rare genetic disorder, characterized by progressive premature aging and early death in the first or second decade of life, usually secondary to cardiovascular events (myocardial infarction and stroke). We report a case of a 14-year-old boy with progeria syndrome and cardiac arrest due to myocardial infarction, who was submitted to an immediate coronary angiography which revealed left main stem and three-vessel coronary artery disease. A prompt double bypass coronary artery grafting surgery was performed, and, despite successful coronary reperfusion, the patient remained in coma and brain death was declared on fourth day after surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2150135118803596DOI Listing

Coronary Microcirculation Downstream Non-Infarct-Related Arteries in the Subacute Phase of Myocardial Infarction: Implications for Physiology-Guided Revascularization.

J Am Heart Assoc 2019 May;8(9):e011534

1 Hospital Clínico San Carlos IDISSC and Universidad Complutense de Madrid Madrid Spain.

Background Concerns exist about reliability of pressure-wire-guided coronary revascularization of non-infarct-related arteries (non- IRA ). We investigated whether physiological assessment of non- IRA during the subacute phase of myocardial infarction might be flawed by microcirculatory dysfunction. Methods and Results We analyzed non- IRA that underwent fractional flow reserve, coronary flow reserve, and the index of microcirculatory resistance assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.118.011534DOI Listing

The incremental value of neuropsychological assessment: a critical review.

Authors:
Jacobus Donders

Clin Neuropsychol 2019 Apr 23:1-32. Epub 2019 Apr 23.

a Department of Psychology , Mary Free Bed Rehabilitation Hospital , Grand Rapids , MI , USA.

Objective: The purpose of this critical review was to evaluate the current state of research regarding the incremental value of neuropsychological assessment in clinical practice, above and beyond what can be accounted for on the basis of demographic, medical, and other diagnostic variables. The focus was on neurological and other medical conditions across the lifespan where there is known risk for presence or future development of cognitive impairment.

Method: Eligible investigations were group studies that had been published after 01/01/2000 in English in peer-reviewed journals and that had used standardized neuropsychological measures and reported on objective outcome criterion variables. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13854046.2019.1575471DOI Listing

Dexmedetomidine improves cognition after carotid endarterectomy by inhibiting cerebral inflammation and enhancing brain-derived neurotrophic factor expression.

J Int Med Res 2019 Apr 24:300060519843738. Epub 2019 Apr 24.

1 Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou City, Jiangsu Province, China.

Objectives: Carotid endarterectomy (CEA) is efficient in preventing stroke for patients with significant carotid stenosis, but results in mild cognitive dysfunction. Dexmedetomidine is neuroprotective in stroke models. We hypothesized that dexmedetomidine may improve cognition after CEA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060519843738DOI Listing

Diagnosis and management of central sleep apnea syndrome.

Expert Rev Respir Med 2019 Apr 24:1-13. Epub 2019 Apr 24.

a Grenoble Alpes University , HP2 Laboratory , INSERM U1042, Grenoble , France.

Introduction: Central sleep apnea (CSA) syndrome has gained a considerable interest in the sleep field within the last 10 years. It is overrepresented in particular subpopulations such as patients with stroke or heart failure. Early detection and diagnosis, as well as appropriate treatment of central breathing disturbances during sleep remain challenging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1604226DOI Listing

Baseline fasting plasma insulin levels predict risk for major adverse cardiovascular events among patients with diabetes and high-risk vascular disease: Insights from the ACCELERATE trial.

Diab Vasc Dis Res 2019 Mar;16(2):171-177

1 Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Background: Despite optimal treatment, type II diabetes mellitus remains associated with an increased risk for future cardiovascular events. We sought to determine the association between baseline fasting plasma insulin levels and major adverse cardiovascular outcomes in patients with type II diabetes mellitus and high-risk vascular disease enrolled in the ACCELERATE (Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition with Evacetrapib in Patients at a High Risk for Vascular Outcomes) trial.

Methods: We included all patients with type II diabetes mellitus who had a central laboratory measured fasting plasma insulin level drawn at baseline as part of the study protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1479164119827604DOI Listing
March 2019
1 Read

A prospective survey of the persistence of warfarin or NOAC in nonvalvular atrial fibrillation: a COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF).

Korean J Intern Med 2019 Apr 25. Epub 2019 Apr 25.

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: Efforts to reduce stroke in patients with atrial fibrillation (AF) have focused on increasing physician adherence to oral anticoagulant (OAC) guidelines; however, the high early discontinuation rate of vitamin K antagonists (VKAs) is a limitation. Although non-VKA OACs (NOACs) are more convenient to administer than warfarin, their lack of monitoring may predispose patients to nonpersistence. We compared the persistence of NOAC and VKA treatment for AF in real-world practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3904/kjim.2017.415DOI Listing

Impact of Antithrombotic Regimen and Platelet Inhibition Extent on Leaflet Thrombosis Detected by Cardiac MDCT after Transcatheter Aortic Valve Replacement.

J Clin Med 2019 Apr 12;8(4). Epub 2019 Apr 12.

Université de Strasbourg, Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, 67000 Strasbourg, France.

The impact of antithrombotic regimen and platelet inhibition extent on subclinical leaflet thrombosis (SLT) detected by cardiac multidetector computed tomography (MDCT) after transcatheter aortic valve replacement (TAVR) is not well established. Hypoattenuation affecting motion (HAM) has been proposed as a surrogate marker of SLT, and is characterized by hypoattenuated leaflet thickening (HALT) and concomitant reduction in leaflet motion (RELM). We sought to investigate (i) the prevalence of HAM and HALT after TAVR detected by MDCT, (ii) the predictors of SLT, (iii) the impact of oral anticoagulant (OAC) and platelet inhibition extent assessed by platelet reactivity index vasodilator stimulated phosphoprotein (PRI-VASP) and closure time adenosine diphosphate (CT-ADP) on SLT. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/2077-0383/8/4/506
Publisher Site
http://dx.doi.org/10.3390/jcm8040506DOI Listing
April 2019
1 Read

Does Herpes Zoster Increase the Risk of Stroke and Myocardial Infarction? A Comprehensive Review.

J Clin Med 2019 Apr 22;8(4). Epub 2019 Apr 22.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Herpes zoster (HZ) caused by varicella zoster virus (VZV) reactivation is characterized as a vesicular rash of unilateral distribution that can also cause multiple complications; such as post-herpetic neuralgia; ophthalmic zoster; and other neurological issues. VZV can also increase incident hemorrhagic or ischemic complications by causing inflammatory vasculopathy. Thus; emerging epidemiological and clinical data recognizes an association between HZ and subsequent acute strokes or myocardial infarction (MI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8040547DOI Listing

Brain Atrophy Estimated from Structural Magnetic Resonance Imaging as a Marker of Large-Scale Network-Based Neurodegeneration in Aging and Stroke.

Authors:
Michele Veldsman

Geriatrics (Basel) 2017 Nov 10;2(4). Epub 2017 Nov 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Brain atrophy is a normal part of healthy aging, and stroke appears to have neurodegenerative effects, accelerating this atrophy to pathological levels. The distributed pattern of atrophy in healthy aging suggests that large-scale brain networks may be involved. At the same time, the network wide effects of stroke are beginning to be appreciated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2040034DOI Listing
November 2017

Management of Acute Stroke in the Older Person.

Geriatrics (Basel) 2017 Aug 15;2(3). Epub 2017 Aug 15.

Stroke Research in Stoke, University Hospitals of North Midlands NHS Trust, Newcastle Road, Stoke-on-Trent ST4 6QG, UK.

The majority of people who suffer a stroke are older adults. The last two decades have brought major progress in the diagnosis and management of stroke, which has led to significant reductions in mortality, long-term disability, and the need for institutional care. However, acute, interventional and preventative treatments have mostly been trialled in younger age groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2030027DOI Listing

Determinants of Length of Stay Following Total Anterior Circulatory Stroke.

Geriatrics (Basel) 2017 Aug 4;2(3). Epub 2017 Aug 4.

Ageing Clinical & Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Identification of factors that determine length of stay (LOS) in total anterior circulatory stroke (TACS) has potential for targeted intervention to reduce the associated health care burden. This study aimed to determine which factors predict LOS following either ischaemic or haemorrhagic TACS. The study sample population was drawn from the Norfolk and Norwich Stroke and Transient Ischemic Attack (TIA) Register (1996⁻2012), a prospective registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2030026DOI Listing

Stroke in Frail Older People.

Authors:
David G Smithard

Geriatrics (Basel) 2017 Jul 15;2(3). Epub 2017 Jul 15.

Department of Electronic and Digital Arts, University of Kent, Canterbury CT2 7NZ, UK.

The population is ageing, with the greatest proportional increase in those >80 years of age. Many of these people will be frail and at risk of stroke. Research has shown that the very old have much to benefit from hyperacute stroke intervention, but at the same time they suffer increased mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2030024DOI Listing

Cervical Fractures: Does Injury Level Impact the Incidence of Dysphagia in Elderly Patients?

Geriatrics (Basel) 2017 Jul 12;2(3). Epub 2017 Jul 12.

Trauma Services, Grant Medical Center, 111 South Grant Avenue, Columbus, OH 43215, USA.

Dysphagia is common in the elderly with significant consequences such as aspiration and malnutrition. This study seeks to investigate oropharyngeal dysphagia in elderly patients with cervical fractures and determine whether the level of cervical fracture impacts the incidence of swallowing dysfunction. Records of trauma patients ≥65 admitted with cervical fractures over a 76-month period to a level 1 trauma center were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2030021DOI Listing

Risk Prediction Models for Post-Stroke Dementia.

Geriatrics (Basel) 2017 Jun 22;2(3). Epub 2017 Jun 22.

Newcastle University Institute of Ageing, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

A strong association exists between stroke and dementia with both diseases linked to ageing. Survival rates from stroke are improving which would equate to an ever-expanding population of patients at risk of future dementia. Early or timelier identification of dementia has become a priority in many countries, including the UK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2030019DOI Listing

Stroke in Older Survivors of Ischemic Stroke: Standard Care or Something Different?

Geriatrics (Basel) 2017 Jun 19;2(2). Epub 2017 Jun 19.

Neurology Department, Calvary Mater Hospital, Newcastle, NSW 2293, Australia.

Stroke is one of the leading causes of death and disability and it is more likely to occur in those who are older. Because people are living longer, the definition of "old" continues to evolve. Age alone should not influence the healthcare that a patient receives, however, evidence indicates that this does occur, especially in older patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2020018DOI Listing

Racial Differences in Patient-Reported Post-Stroke Disability in Older Adults.

Geriatrics (Basel) 2017 May 23;2(2). Epub 2017 May 23.

Division of Healthcare Studies, College of Health Professions, Medical University of South Carolina, 151-B Rutledge Ave, Charleston, SC 29425, USA.

Longstanding disparities have been reported in stroke-related outcomes with blacks experiencing more post-stroke disabilities. Little is known about long-term disability outcomes among older stroke survivors. This study was a retrospective analysis of data from the 2015 National Health Interview Survey (NHIS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2020016DOI Listing

Memory and Learning Complaints in Relation to Depression among Elderly People with Multimorbidity.

Geriatrics (Basel) 2017 May 9;2(2). Epub 2017 May 9.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Although current models of care are generally well-suited to providing treatment for individual medical conditions, the emergence of multimorbidity is becoming a serious concern for practitioners and policy researchers, particularly in developing countries. The challenges of tackling multimorbidity are further compounded when the multimorbidity co-occurs with psychiatric conditions such as cognitive and depressive disorders. Understanding the relationships between multimorbidity and psychiatric illnesses is therefore of considerable clinical importance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2020015DOI Listing

iPad Use in Stroke Neuro-Rehabilitation.

Geriatrics (Basel) 2017 Jan 6;2(1). Epub 2017 Jan 6.

Academic Department of Geriatrics, Brighton and Sussex Medical School, Brighton, BN2 5BE, UK.

Neuro-rehabilitation services are essential in reducing post-stroke impairments, enhancing independence, and improving recovery in hospital and post-discharge. However these services are therapist-dependent and resource intensive. Patients' disengagement and boredom in stroke units are common which adversely affect functional and psychological outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/geriatrics2010002DOI Listing
January 2017

Effects of Acupuncture Treatment on Lower Limb Spasticity in Patients Following Hemorrhagic Stroke: A Pilot Study.

Eur Neurol 2019 Apr 23;81(1-2):5-12. Epub 2019 Apr 23.

Department of Traditional Chinese Medicine, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background And Purpose: Lower limb spasticity is often a significant problem in stoke rehabilitation. The purpose of this study was to investigate the effects of acupuncture treatment on lower limb spasticity in patients following hemorrhagic stroke.

Methods: Fifty-nine patients following hemorrhagic stroke were randomized to receive acupuncture treatment combined with conventional treatment (treatment group [TG]) or conventional treatment only (control group [CG]). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499133DOI Listing

Microbleeds of Lacunar Infarction and Middle Cerebral Artery Flow Velocity of Branch Atheromatous Disease Are Essential Factors of Stroke Etiology.

Eur Neurol 2019 Apr 23;81(1-2):19-23. Epub 2019 Apr 23.

Department of Neurology, Jikei University School of Medicine, Tokyo, Japan.

Background: Although subcortical infarction patients sometimes show larger infarction size than the definition of small vessel occlusion (SVO), there are no specific predictors of larger size. The aim of this study was to identify the factors, including magnetic resonance imaging (MRI) and ultrasonographic parameters, to predict larger subcortical infarction.

Methods: Consecutive patients with acute supratentorial subcortical infarction were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494672DOI Listing