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Am J Clin Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Background: Striae distensae (SD), an unsightly cutaneous condition characterized by epidermal atrophy, can affect the quality of life of women.

Objectives: The aim of our study was to compare the efficacy of a neodymium:yttrium-aluminum-perovskite 1340 nm non-ablative fractional laser (NAFL) and the microneedling (MN) technique to treat striae alba (SA).

Materials And Methods: NAFL and MN were used to treat striae on the longitudinally divided abdominal surface of 20 women classified as Fitzpatrick skin type III or IV (five sessions at monthly intervals). Read More

Lasers Surg Med 2019 Jan 6. Epub 2019 Jan 6.

Department of Pathology and Forensic Medicine, Thammasat University, Pathumthani, Thailand.

Objectives: Striae distensae are linear atrophic dermal scars. Despite several currently available therapeutic modalities, no consistently effective therapies have been established. This study aimed to evaluate and compare the efficacy of topical recombinant human epidermal growth factor (rhEGF) and ablative fractional carbon dioxide (CO ) laser (AFXL) versus ablative fractional CO laser and topical Aloe vera gel in treating striae alba. Read More

Lasers Surg Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Plastic, Reconstructive and Maxillo facial Surgery, Hopital Henri Mondor, Creteil, 94010, France.

Background And Objective: Striae distensae (SD) are cutaneous lesions that often occur on the breasts, abdomen, hips, and thighs. The aim of this study is to evaluate the effectiveness of a new technique using a non-invasive Er:YAG laser combined with Spatially Modulated Ablation (SMA) module for the treatment of SD.

Study Design/materials And Methods: This prospective pilot clinical study included 20 patients with skin phototypes I to IV who are affected by SD. Read More

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

Skin Res Technol 2018 Oct 22. Epub 2018 Oct 22.

Clinical Research Center, Institut d'Expertise Clinique (IEC) Korea, Suwony, Gyeonggi-do, Korea.

Background: Striae distensae are common dermal lesions that progress through two different stages: the striae rubra, which appears to be erythematous, and striae alba, which is characterized by a hypopigmented feature. The clinical characteristics between striae distensae stages and normal skin remain unknown.

Objectives: We aimed to investigate the clinical characteristics according to stages of striae distensae in terms of their biophysical properties, using objective noninvasive measurements in comparison with adjacent normal skin. Read More

J Cosmet Laser Ther 2018 Oct 15:1-8. Epub 2018 Oct 15.

c Faculty of Medicine , Cairo University , Egypt.

Background: Fractional photothermolysis is creation of microscopic thermal zones of controlled depth, width and density. Microneedling is a simple treatment modality to reduce striae distensae.

Objective: Evaluate and compare the efficacy of fractional carbon dioxide laser and microneedling as a treatment of striae distensae. Read More

Trials 2018 Oct 12;19(1):553. Epub 2018 Oct 12.

School of Nursing & Midwifery, Aras Moyola, National University of Ireland Galway, Galway, H91 TK33, Ireland.

Background: Striae gravidarum (stretch marks) are considered the most common connective tissue/skin change in pregnancy. Though not a health issue they can affect women in different ways, for example, cause stress or be an aesthetic or cosmetic concern. Many women use one or more of the commercially available products to try and prevent their development during pregnancy despite the fact that that there is a lack of high-quality evidence to support their use. Read More

Minerva Ginecol 2018 Oct;70(5):629-634

IRVINE3 Labs, Department of Medical and Oral Sciences, and Biotechnologies, G. D'Annunzio University, Chieti, Italy.

Background: This registry study evaluates the effects of oral Centellicum®, a new preparation of Centella asiatica (CA) on cutaneous stretchmarks (SMs) on the lower abdominal wall in comparison with the topical treatment with a specific antistretch cream. This cream is used for pregnancy SMs. The aim of the management was to give back to the structurally damaged skin areas (apparent as SMs) a normal elasticity and resistance and improving the local microcirculation. Read More

Dermatol Ther 2019 Jan 21;32(1):e12750. Epub 2018 Oct 21.

Department of Dermatology, Virgen del Rocio University Hospital, Seville, Spain.

J Eur Acad Dermatol Venereol 2019 Jan 8;33(1):220-226. Epub 2018 Oct 8.

Clinic of Dermatology and Allergy, Department for Aesthetic Dermatology and Laser Medicine, Ludwig-Maximilian-University, Munich, Germany.

Background And Objective: Striae distensae (SD) represent therapeutically challenging forms of dermal atrophic scarring. In addition to topical ointments, medical needling and various energy-based devices, non-ablative fractional lasers have been suggested for their improvement. However, objective evaluations of their efficacy are widely missing. Read More

J Cosmet Laser Ther 2018 Aug 21:1-4. Epub 2018 Aug 21.

a Department of Clinical Medicine and Surgery, Section of Dermatology , University of Naples Federico II , Naples , Italy.

Striae distensae or stretch marks are dermal scars characterized by flattening and atrophy of the epidermis. They develop particularly during adolescence but they can also appear in other situations such as pregnancy, the use of prolonged therapies with topical or systemic corticosteroids, Cushing's syndrome, Marfan's syndrome, prolonged use of lightening creams, cachexia, rapid weight loss or the use of androgenic and anabolic substances. Treatment options often take a long time, and the results are often disappointing, causing significant psychological distress in patients. Read More

J Dermatolog Treat 2018 Sep 7:1-9. Epub 2018 Sep 7.

c Department of Dermatologic Surgery and Laser Unit, St. John's Institute of Dermatology , St. Thomas' Hospital , London , UK.

Background: Striae distensae are caused by rapid stretching of the skin. They are often secondary to obesity or pregnancy and can lead to significant cosmetic disfigurement.

Aim: To determine the efficacy, indications, and side effects of commonly used energy devices in the treatment of striae. Read More

Australas J Dermatol 2018 Jul 26. Epub 2018 Jul 26.

Women's and Children's Hospital, Adelaide, South Australia, Australia.

Pak J Med Sci 2018 May-Jun;34(3):568-573

YaseminTasci, Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care Training and Research Hospital, Ankara, Turkey.

Objective: To evaluate the relationship between striae gravidarum (SG) score and abdominal scar characteristics together with intraperitoneal adhesion (IPA) grades of patients who were hospitalized for second cesarean delivery.

Methods: A total of 145 consecutive women undergoing scheduled cesarean section (CS) in a tertiary level maternity hospital between November 2013 and January 2014 were included in the study. All women had transverse suprapubic skin incision due to the previous CS and none of them had a history of vaginal delivery. Read More

Int J Dermatol 2018 10 18;57(10):e82-e83. Epub 2018 Jul 18.

Department of Anatomic Pathology, Hospital Universitario Virgen Macarena, Seville, Spain.

J Cosmet Laser Ther 2018 Jul 6:1-5. Epub 2018 Jul 6.

c Medical laser Research Group, Medical Laser Research Center, ACECR , Tehran , Iran.

Striae distensae (SD) are atrophic dermal scars often found on abdomen, breasts, thighs, and hips of pregnant women. The strias' self-healing without any intervention is a poor possibility. Till now, several lasers and light sources have been used for treatment of SD. Read More

Dermatol Clin 2018 Jul 26;36(3):259-265. Epub 2018 Apr 26.

Division of Dermatology, Ohio State University College of Medicine, 540 Officenter Place, #240, Gahanna, OH 43230, USA. Electronic address:

Pruritus in pregnancy can be a source of significant discomfort in the pregnant patient. Some cases are associated with pregnancy-specific dermatoses, although some patients experience a flare of a preexisting dermatosis. Severe pruritus may be a manifestation of a pregnancy-specific dermatosis associated with increased fetal risks and complications. Read More

PLoS One 2018 21;13(6):e0198720. Epub 2018 Jun 21.

Department of Dermatology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.

Background: Striae gravidarum is a common skin problem of considerable cosmetic concern for many pregnant women. Various risk factors associated with the development of striae have been reported, with conflicting results.

Objectives: To analyze the risk factors of striae gravidarum in Chinese primiparous women and to provide evidence relevant to the prevention of this condition. Read More

J Cosmet Dermatol 2018 Jun 19. Epub 2018 Jun 19.

Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Background: Striae distensae are very common cutaneous disorders that produce great psychological stress for women.

Objective: measure and compare between efficacy and tolerability of three modalities for treatment of striae distensae.

Patients And Methods: Forty-five female patients with striae distensae were randomly selected from the outpatient dermatology clinics of Al-Zahra university Hospital within 6 months period. Read More

J Am Acad Dermatol 2018 Dec 8;79(6):e107-e108. Epub 2018 Jun 8.

Sanjay Gandhi Memorial Hospital, New Delhi, India.

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

Dermatol Surg 2018 10;44(10):1311-1316

Cosmetic Laser Dermatology, San Diego, California.

Background: Few effective treatments exist for striae alba, which are the mature stage of stretch marks.

Objective: To evaluate the efficacy of the nonablative fractional 1,565-nm Erbium-glass (Er:glass) and the picosecond fractional 1,064/532-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) lasers in the treatment of striae alba.

Materials And Methods: Twenty subjects with striae alba on the bilateral abdomen were treated with either the nonablative fractional 1565-nm Er:glass or the picosecond fractional 1,064/532-nm Nd:YAG laser, with a total of 3 treatments 3 weeks apart. Read More

Dermatol Surg 2018 May;44(5):697-704

All authors are affiliated with the Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Striae distensae (SD) are dermal scars associated with atrophy of the epidermis.

Objective: To evaluate the effect and safety of intralesional injection of platelet-rich plasma (PRP) versus topical tretinoin 0.05% in treatment of SD. Read More

Br J Dermatol 2018 Apr;178(4):e278

Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Straße 29, 80802, Munich, Germany.

J Cosmet Laser Ther 2019 16;21(1):39-43. Epub 2018 Mar 16.

c Doctor , Post-Graduate Program in Rehabilitation Sciences - UNIFAL-MG , Alfenas , Minas Gerais , Brazil.

Objective: To assess the effects of galvano-puncture (GG) and dermabrasion (DG) in reducing striae distensae in the gluteal region of women.

Methods: This randomized, controlled, single-blind clinical trial was conducted at the UNIFAL-MG. Participants were 48 female who had striae distensae alba in the gluteal region. Read More

Endocr Pract 2018 08 2;24(8):766. Epub 2018 Mar 2.

From the 1Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

J Cosmet Dermatol 2019 Feb 1;18(1):342-345. Epub 2018 Mar 1.

Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Łódź, Poland.

Background: Striae have been reported to be one of the most common skin lesions and a commonly encountered esthetic problem.

Objectives: The aim of this research was to examine elastin gene polymorphism (rs7787362, ELN) and collagen type III alpha 1 polymorphism (rs1800255, COL3A1) among polish woman population with SD in comparison with women without the lesions and to verify these polymorphisms as risk factors for SD.

Methods: Seventy female students (35 with striae (the mean age 23. Read More

J Cosmet Laser Ther 2019 16;21(1):49-57. Epub 2018 Feb 16.

b Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre , Guy's and St Thomas' NHS Foundation Trust , London , UK.

Striae distensae (SD), otherwise known as "stretchmarks," are a common presenting complaint, particularly in young healthy women. SD are hypothesized to form in a patient when the cross-linked collagen is "overstretched" and rupture of this collagen matrix causes the striae. Thus, many treatments work by increasing collagen synthesis. Read More

J Cosmet Dermatol 2018 Dec 7;17(6):1008-1015. Epub 2018 Jan 7.

Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Striae distensae are dermal scars with a linear atrophic depression. The exact origin of striae distensae remains unrevealed, but low expression of collagen and fibronectin genes in the affected tissue was found. Several treatment modalities have been proposed, yet no consistent modality is available. Read More

Lasers Med Sci 2018 Apr 7;33(3):609-617. Epub 2018 Jan 7.

Biomedical Engineering Innovation Center, Biomedical Vibrational Spectroscopy Group, Universidade Brasil-UNBr, Rua Carolina Fonseca, 235-08230-030, Itaquera, Sao Paulo, Brazil.

This research work mainly deals with studying qualitatively the changes in the dermal collagen of two forms of striae distensae (SD) namely striae rubrae (SR) and striae albae (SA) when compared to normal skin (NS) using confocal Raman spectroscopy. The methodology includes an in vivo human skin study for the comparison of confocal Raman spectra of dermis region of SR, SA, and NS by supervised multivariate analysis using partial least squares discriminant analysis (PLS-DA) to determine qualitatively the changes in dermal collagen. These groups are further analyzed for the extent of hydration of dermal collagen by studying the changes in the water content bound to it. Read More

J Am Acad Dermatol 2018 Aug 24;79(2):363-364. Epub 2017 Dec 24.

Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.

J Cosmet Dermatol 2018 Dec 6;17(6):1170-1174. Epub 2017 Dec 6.

Chair of Cosmetology, Faculty of Pharmacy, Department of Cosmetology and Aesthetic Dermatology, Medical University of Łódź, Łódź, Poland.

Objective: The aim of the study was to evaluate the effectiveness of carboxytherapy in the treatment of striae distensae. Additionally, discomfort and side effects associated with the treatment were assessed.

Materials And Methods: This study involved 15 women aged 22-40 years. Read More

Pediatr Dermatol 2018 Jan 21;35(1):59-63. Epub 2017 Nov 21.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Background: This study examines the clinical characteristics and demographics of teenage boys with horizontal striae distensae of the lower back in an outpatient setting.

Methods: Retrospective medical chart reviews and telephone survey studies were completed on an outpatient cohort of 12 boys 11 to 17 years of age with a clinical diagnosis of transverse striae distensae of the lower back at a single-center, university-based, pediatric dermatology practice. We evaluated the clinical features of the striae, participant demographic characteristics, and past medical history. Read More

Dermatol Surg 2018 08;44(8):1151-1153

Pinnacle Dermatology, Joliet, Illinois Dermatology Section, Edward Hines Jr. VA Hospital, Hines, Illinois Department of Dermatology, Mayo Clinic, Rochester, Minnesota Division of Dermatology, Loyola University, Maywood, Illinois.

J Cosmet Dermatol 2018 Dec 6;17(6):1165-1169. Epub 2017 Nov 6.

Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Lodz, Poland.

Background: Striae have been reported to be one of the most common skin changes and a commonly encountered esthetic problem.

Objectives: To analyze risk factors of striae not associated with pregnancy and verify if body build and composition influence striae distensae (SD) occurrence and visibility.

Methods: Eighty female students (40 with striae (the mean age 23. Read More

Int J Cosmet Sci 2018 Feb 12;40(1):81-86. Epub 2017 Dec 12.

proDERM, Institute for Applied Dermatological Research GmbH, Kiebitzweg 2, Schenefeld/Hamburg, DE 22869, Germany.

Objective: The normal process of skin tissue repair following injury invariably results in visual scarring. It is known that topical treatment with hydrophobic cosmetics rich in silicone and mineral oil content can improve the appearance of scars and striae. Given lifestyle preferences of many cosmetic consumers towards so-called natural treatments, the objective of this controlled randomized study was to investigate the efficacy of a plant body oil rich in oleic and linoleic acids (Bio Skin Oil ) for improving the appearance of scars and striae. Read More

Lasers Med Sci 2018 Jan 4;33(1):75-78. Epub 2017 Oct 4.

I.C.L.I.D, Milan, Italy.

The efficacy of NAFL in the treatment of striae distensae (SD) has been demonstrated. Nevertheless, the base for this improvement has not been clarified yet. The aim of this study is to describe in vivo variations occurring in the skin after the treatment, using reflectance confocal microscopy (RCM). Read More

Ann Dermatol 2017 Oct 25;29(5):633-634. Epub 2017 Aug 25.

Department of Dermatology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.

Ecancermedicalscience 2017 7;11:756. Epub 2017 Aug 7.

Department of Pediatric Hematology and Oncology, AP-HM, Boulevard Jean Moulin, 13005, Marseille France.

Glioblastoma cerebri is a rare paediatric malignancy with dismal prognosis [Chappé C, Riffaud L, and Tréguier C (2013) 565-571 https://doi.org/10.1007/s00381-012-2016-1 PMID: 23306961] and no established standard of care. Read More

Midwifery 2017 Nov 1;54:25-28. Epub 2017 Aug 1.

Henrietta Szold/Hadassah-Hebrew University School of Nursing, Faculty of Medicine, Jerusalem, Israel.

Objectives: to examine the association between the severities of Striae Gravidarum (SG) and Obstetric Anal Sphincter Injuries (OASIS) and to measure the symptoms regarding urinary incontinence, fecal/flatus incontinence, and dyspareunia, at 6 and 12 months postpartum.

Design: this is a cohort study.

Setting: four university teaching medical centers in Israel, two in the north and two in the center of the country. Read More

J Cosmet Dermatol 2017 Dec 9;16(4):466-470. Epub 2017 Aug 9.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Striae distensae (SD) are a frequent skin condition for which treatment remains a challenge. Various laser treatments have been employed to remove the epidermis and cause dermal wound and heating with subsequent dermal collagen remodeling.

Objective: To determine the efficacy and safety of a variable square pulse Erbium: YAG (VSP Er:YAG) laser for the treatment of striae in skin phototypes III-IV. Read More

J Cosmet Dermatol 2018 Apr 29;17(2):176-183. Epub 2017 Jul 29.

Department of Dermatology, Huadong Hospital, Fudan University, Shanghai, China.

Background: Striae distensae (SD) are a common dermatologic problem that plagues many people. Although there are many therapeutic modalities have been used to treat SD, effective method has been disappointing for striae Alba.

Aims: To evaluate the clinical and histopathologic efficacy and safety of the 2940-nm erbium yttrium aluminum garnet (Er:YAG) ablative fractional laser (AFL) with recombinant bovine basic fibroblast growth factor (rb-bFGF) and light-emitting diode-red light (LED-RL) for the treatment of striae alba. Read More

CMAJ 2017 07;189(28):E942

Department of Medicine (Jogova, Hwang), University of Toronto; Centre for Urban Health Solutions (Hwang), St. Michael's Hospital, Toronto, Ont.

J Plast Reconstr Aesthet Surg 2018 Jan 17;71(1):1-14. Epub 2017 Jun 17.

Department of Plastic and Reconstructive Surgery - Burn Center, University Hospital of Ghent, De Pintelaan 185, 9000 Ghent, Belgium.

Background: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. Read More

J Cosmet Laser Ther 2017 Nov 30;19(7):378-382. Epub 2017 Jun 30.

a Department of Dermatology , Koc University School of Medicine , Istanbul , Turkey.

Background: Striae distensae (SD) are a type of dermal scarring that is quite common and difficult to treat. Two forms are known: striae rubrae (SR) and striae albae (SA).

Objective: We compared the long-term clinical effectiveness of a 1550-nm non-ablative fractional laser (NAFL) in treating SR and SA. Read More

J Cosmet Laser Ther 2017 Dec 30;19(8):479-484. Epub 2017 Jun 30.

a Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital , Catholic Kwandong University, College of Medicine , Incheon , Republic of Korea.

Background: Needleless transcutaneous pneumatic injections (TPIs) are a minimally invasive way to deliver the solution into the skin for therapeutic purposes. The suggested action mechanisms of TPI therapy include mechanical stimulation, immediate tissue shrinkage and late wound healing.

Methods: Thirteen Korean patients were treated with TPI for atrophic skin disorders, including acne scars, striae albae, post-furuncle, or carbuncle scars, and horizontal wrinkles with lipoatrophy. Read More

Endocr Pract 2017 Aug 14;23(8):962-970. Epub 2017 Jun 14.

Objective: Cushing disease (CD) results from excessive exposure to glucocorticoids caused by an adrenocorticotropic hormone-secreting pituitary tumor. Inadequately treated CD is associated with significant morbidity and elevated mortality. Multicenter data on CD patients treated in routine clinical practice are needed to assess treatment outcomes in this rare disorder. Read More

Int J Womens Dermatol 2017 Jun 6;3(2):77-85. Epub 2016 Dec 6.

Department of Dermatology, Palo Alto Foundation Medical Group, Mountain View, CA.

Background: Striae gravidarum (SG) are atrophic linear scars that represent one of the most common connective tissue changes during pregnancy. SG can cause emotional and psychological distress for many women. Research on risk factors, prevention, and management of SG has been often inconclusive. Read More

J Am Acad Dermatol 2017 Sep 24;77(3):559-568.e18. Epub 2017 May 24.

Centre for Dermatological Research, University of Manchester, Manchester, United Kingdom. Electronic address:

Background: Striae distensae are permanent dermal lesions that can cause significant psychosocial distress. A detailed understanding of the numerous treatment modalities available is essential to ensuring optimal patient outcomes.

Objective: Our objective was to evaluate and summarize the different treatment methods for striae distensae by linking their proposed modes of action with the histopathogenesis of the condition to guide patient treatment. Read More