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J Cosmet Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.

Platelet-rich plasma (PRP) has recently become a popular treatment for various skin conditions, including striae distensae, acne scars, traumatic scars, hair regrowth, and cutaneous rejuvenation. Although PRP has been utilized in orthopedics for many years, its recent entry into dermatology has been met with controversy. While the recent research has generally been limited and is often contradictory, this has differed from the persuasive marketing campaigns targeting patients and consumers. Read More

J Dermatolog Treat 2020 Jul 2:1-12. Epub 2020 Jul 2.

Faculty of Medicine, Department of Pathology, Assiut University Hospitals, Assiut, Egypt.

Striae distensae (SD) are common skin conditions. This study was done to test the hypothesis that 'the use of microneedling (MN) before platelet-rich plasma (PRP) application will allow for deeper penetration and therefore, augment its efficacy in the treatment of SD.' Forty patients with SD were divided into (i) Group I, the patients were treated with MN only, and (ii) Group II, the patients were treated with combined MN-PRP. Read More

Indian Dermatol Online J 2020 Mar-Apr;11(2):280-281. Epub 2020 Mar 9.

Department of Dermatology, Aga Khan University Hospital, Karachi, Pakistan.

J Cosmet Dermatol 2020 May 28. Epub 2020 May 28.

Laser Cutaneous Cosmetic & Plastic Surgery Unit, Villa Donatello Clinic, Florence, Italy.

Background: Postpartum abdominal changes represent a major esthetic concern affecting women. As the abdomen stretches during pregnancy and some of the muscles lose tone, there is an increased skin laxity and a loss of abdominal elasticity. As a result, the abdomen becomes saggy. Read More

Lasers Surg Med 2020 May 22. Epub 2020 May 22.

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju-si, Gangwon-do, 26426, Republic of Korea.

Background And Objectives: To evaluate the safety and effectiveness of combined fractional radiofrequency microneedling (FRM) and fractional carbon dioxide (FCO ) laser treatment for striae distensae and to compare the results to those of FRM alone and those of FCO alone.

Study Design/materials And Methods: Adult women (Fitzpatrick skin types III-IV) with striae distensae on the abdomen or calf were enrolled in this study. Each lesion was divided into three regions, with each region assigned to one of the three treatments (FCO , FRM, or combined FCO and FRM). Read More

J Cosmet Sci 2020 Mar/Apirl;71(2):77-90

Aesthetic and Reconstructive Oculoplastic Surgery, Beverly Hills, California 90212 (R.K., A.W., B.K., C.I.Z.), Department of Plastic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 (E.M.W.), Division of Applied Statistics, Victoria University of Wellington, Wellington, New Zealand 6140 (V.P.).

Striae distensae (SD) are linear dermal scars that arise from progressive stretching or tearing of the dermal layer. This study tests the safety and efficacy of a topical formulation of silicone-based scar cream containing selective synthetic recombinant human growth factors, hyaluronic acid, and vitamin C to improve overall appearance and texture of SD. Twenty-two subjects with SD alba were recruited and randomized to apply the topical formula to half of their SD laterally twice a day for 1 month. Read More

Pediatr Nephrol 2020 Jul 19;35(7):1235-1246. Epub 2020 Mar 19.

Department of Paediatric Kidney, Liver and Metabolic Diseases, Paediatric Research Center, Hannover Medical School Children's Hospital, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background: Children presenting with proliferative lupus nephritis (LN) are treated with intensified immunosuppressive protocols. Data on renal outcome and treatment toxicity is scare.

Methods: Twelve-month renal outcome and comorbidity were assessed in 79 predominantly Caucasian children with proliferative LN reported to the Lupus Nephritis Registry of the German Society of Paediatric Nephrology diagnosed between 1997 and 2015. Read More

Acta Biomed 2020 03 19;91(1):176-181. Epub 2020 Mar 19.

Pediatrics Department, Ain Shams University, Cairo, Egypt.

Striae distensae or stretch marks are mainly a cosmetic concern. They commonly occur in adolescence and in pregnant women. Although, generally more common in females; physiological striae atrophicae of adolescence are more common in males. Read More

J Eur Acad Dermatol Venereol 2020 Feb 6. Epub 2020 Feb 6.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Backgrounds: Striae distensae (SD) has a known psychological impact due to the resulting cosmetic disfigurement. Many treatment modalities have been used over the years, but no standard interventions or evaluation methods have been proposed to date.

Objective: We compared the efficacy and safety of non-insulated microneedle radiofrequency (NIMRF) and fractional CO laser treatments of SD by objective measurements with dermoscopy and VISIA. Read More

Skinmed 2019;17(5):318-319. Epub 2019 Sep 1.

From the Division of Dermatology, Departments of Medicine and Pediatrics, Cooper Medical School of Rowan University, Marlton, NJ;

J Am Acad Dermatol 2019 Nov;81(5):1037-1057

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida; Veterans Affairs Miami Health Care System, Miami, Florida. Electronic address:

Obesity is a worldwide major public health problem with an alarmingly increasing prevalence over the past 2 decades. The consequences of obesity in the skin are underestimated. In this paper, we review the effect of obesity on the skin, including how increased body mass index affects skin physiology, skin barrier, collagen structure, and wound healing. Read More

Skin Therapy Lett 2019 Sep;24(5):1-6

Dr. Jason Emer, West Hollywood, CA, USA

Platelet-rich plasma (PRP) is an autologous serum containing high concentrations of platelets and growth factors. PRP continues to evolve as an important treatment modality with many applications in dermatology, particularly in the areas of hair restoration, skin rejuvenation, acne scars, dermal augmentation, and striae distensae. Furthermore, combining PRP with laser therapies, microneedling, dermal fillers, and autologous fat grafting produces synergistic effects, leading to improved aesthetic results. Read More

Skin Res Technol 2020 Mar 25;26(2):220-225. Epub 2019 Sep 25.

Skincare Research Institute, AMOREPACIFIC R&D Center, Yongin, Korea.

Background: Striae distensae (SD) are skin lesions of parallel streaks, which mostly occur during rapid tissue expansion. Considering the etiological mechanism of SD, including dermal network ruptures and alignment to mechanical stretch, structural directionality or anisotropy could be expected. Non-invasive objective methods for measuring the anisotropy of SD have not been suggested yet. Read More

Taiwan J Obstet Gynecol 2019 Sep;58(5):640-644

Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, 200 Huihe Road, Wuxi, Jiangsu, 214000, PR China. Electronic address:

Objective: We study the risk factors that affect the formation of striae gravidarum in women in Jiangsu Province of China under current living habits.

Materials And Methods: This sample is based on 400 primiparas from obstetric of the Affiliated Hospital of Jiangnan University in Wuxi from February 2017 to October 2017. Among them, there are 200 pregnant women with striae gravidarum and 200 without striae gravidarum. Read More

J Obstet Gynaecol Res 2019 Dec 17;45(12):2358-2363. Epub 2019 Sep 17.

Department of Obstetrics and Gynecology, Faculty of Medicine, Hitit University, Corum, Turkey.

Aim: To evaluate the diagnostic value of striae gravidarum (SG) presence and localization in predicting the intraperitoneal adhesion (IPA) risk in pregnant women with a history of at least one previous cesarean delivery (CD).

Methods: A total of 100 pregnant women with repeated CD were included in this prospective observational study. Patients were divided into three groups according to severity of SG with Davey scoring system. Read More

Dermatol Surg 2020 Apr;46(4):459-464

MKL Dermatology, Vancouver, British Columbia, Canada.

Background: Striae distensae have notoriously been difficult to treat due to their extensive involvement of nonfacial skin. Microneedling with its lack of thermal injury during microneedling treatment renders it a viable treatment option in darker skin tones and nonfacial regions due to the reduced risk of postinflammatory hyperpigmentation.

Objective: To describe the clinical results and side effects of microneedling in a series of 25 individuals with striae distensae. Read More

Indian Dermatol Online J 2019 Jul-Aug;10(4):380-395

Venkat Charmalaya Centre for Advanced Dermatology and Postgraduate Training, Bangalore, Karnataka, India.

Striae distansae (SD) or stretch marks are very common, asymptomatic, skin condition frequently seen among females between 5 to 50 years of ages. It often causes cosmetic morbidity and psychological distress, particularly in women and in certain professions where physical appearances have significant importance. Of late, with the increasing emphasis on cosmetic management and awareness, patients approach dermatologists for stretch marks treatment. Read More

Ginekol Pol 2019 ;90(6):325-330

Department of Obstetrics and Gynecology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.

Objectives: The aim of the present study has been to examine skin scar characteristics and striae gravidarum, considering the reliability of each for predicting adhesions in repeat Caesarean sections.

Material And Methods: A cross-sectional study was done over a period of two years. One hundred pregnant women were invited to participate in the study. Read More

Facial Plast Surg 2019 Jun 12;35(3):248-255. Epub 2019 Jun 12.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Summit, New Jersey.

Laser technology continues to increase in popularity and expand treatment options for patients with common but challenging skin conditions including facial telangiectasias, facial aging, striae distensae, and acne scars. Facial telangiectasias have been estimated to occur in tens of millions of people worldwide. The 585-nm laser was the first to follow the principle of selective photothermolysis for the treatment of cutaneous vascular lesions, but it caused significant postoperative purpura. Read More

J Cosmet Dermatol 2020 Jan 27;19(1):190-198. Epub 2019 May 27.

Grupo Boticário, Research & Development, São José dos Pinhais, Brazil.

Background: Striae distensae, commonly known as stretch marks, are cutaneous lesions that accompany the hormonal upheavals of the major stages of life: puberty and pregnancy. Stretch marks occur in 90% of women, and they appear as red or purple lines that slowly fade to pale lines on the skin. There have been few studies regarding stretch mark origins, and new preventive and corrective treatments are needed. Read More

J Eur Acad Dermatol Venereol 2019 Nov 13;33(11):e399-e400. Epub 2019 Jun 13.

Department of Dermatology, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul 06973, South Korea.

Int J Cosmet Sci 2019 Jun;41(3):311-319

Provital, S.A., Gorgs Llado 200, 08210 Barbera del Valles, Barcelona, Spain.

Objective: Stretch marks are disfiguring skin lesions that often cause problems of self-esteem, but little effort has been put to studying this pathology. We therefore analysed cell cultures of dermal fibroblasts isolated from a striae albae, to thereafter reconstruct a full thickness skin model.

Methods: Human Dermal Fibroblasts (HDF) were isolated from a striae distensae (SD) lesion and from the adjacent non-lesioned skin. Read More

Lasers Med Sci 2019 Sep 1;34(7):1295-1304. Epub 2019 May 1.

Resident of dermatology National Institute of diabetes and endocrinology, Cairo, Egypt.

Striae distensae (SD) cause a cosmetic problem to many patients. Recently, fractional micro-needle radiofrequency (FMR) device has been introduced in treatment of SD. Also, fractional CO laser has been used as a resurfacing laser technique in the treatment of SD. Read More

Acta Dermatovenerol Croat 2019 Mar;27(1):44-46

Sevkiye Copur, MD, Department of Dermatology & Venereology, Istanbul University, Istanbul Medical Faculty , Millet Street (Caddesi), 34093 Capa , Istanbul, Turkey;

Lichen sclerosus (LS), also known as lichen sclerosus et atrophicus, is a chronic inflammatory mucocutaneous disease affecting the genital and/or extragenital areas. Although LS usually occurs alone, its coexistence in morphea patients has been reported in 5.7% and 38. Read More

J Dtsch Dermatol Ges 2019 04;17(4):443-445

Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin Berlin, Berlin.

Dermatol Surg 2019 10;45(10):1245-1252

Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, China.

Background: Striae gravidarum is a common skin condition resulting after pregnancy, caused by fibroblast dysfunction. Although not considered a disease, it may be considered cosmetically unpleasant to sufferers and remains as a therapeutic challenge to date.

Objective: To evaluate the efficacy and safety of a sublative bipolar fractional radiofrequency (FRF) system, associated with 0. Read More

J Eur Acad Dermatol Venereol 2019 08 27;33(8):e286-e288. Epub 2019 Mar 27.

Plastic, Reconstructive and Aesthetic Surgery Clinic, Medical University of Lodz, Kopcinskiego 22, Lodz 90-153, Poland.

J Bone Joint Surg Am 2019 Mar;101(5):392-399

Division of Plastic Surgery, University of California San Diego, San Diego, California.

Background: Patients, particularly those who are young, often develop noticeable orthopaedic scars. In order to achieve minimal scarring, surgeons should attempt to place incisions in skinfolds or skin creases.

Methods: Optimal incision lines can be determined from the direction of stretch marks (striae distensae), which develop perpendicular to lines of tension or main folding lines. Read More

J Dtsch Dermatol Ges 2019 04 21;17(4):443-445. Epub 2019 Feb 21.

Department of Dermatology, Venereology and Allergology, Charité University Medicine, Berlin, Germany.

Lancet 2019 02;393(10170):446

Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.

Am J Clin Dermatol 2019 Apr;20(2):277-287

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Background: Striae distensae (SD), an unsightly cutaneous condition characterized by epidermal atrophy, can affect the quality of life of women.

Objectives: The aim of our study was to compare the efficacy of a neodymium:yttrium-aluminum-perovskite 1340 nm non-ablative fractional laser (NAFL) and the microneedling (MN) technique to treat striae alba (SA).

Materials And Methods: NAFL and MN were used to treat striae on the longitudinally divided abdominal surface of 20 women classified as Fitzpatrick skin type III or IV (five sessions at monthly intervals). Read More

Lasers Surg Med 2020 Feb 6;52(2):166-175. Epub 2019 Jan 6.

Department of Pathology and Forensic Medicine, Thammasat University, Pathumthani, Thailand.

Objectives: Striae distensae are linear atrophic dermal scars. Despite several currently available therapeutic modalities, no consistently effective therapies have been established. This study aimed to evaluate and compare the efficacy of topical recombinant human epidermal growth factor (rhEGF) and ablative fractional carbon dioxide (CO ) laser (AFXL) versus ablative fractional CO laser and topical Aloe vera gel in treating striae alba. Read More

Harefuah 2018 Dec;157(12):787-790

Helen Schneider's Hospital for Women, Rabin Medical Center, Petah Tikva.

Introduction: Striae gravidarum is the second most prevalent skin manifestation after skin pigmentation during pregnancy. Its etiology is uncertain, but it is assumed that changes in the structure of collagen, mediated by hormonal changes during pregnancy, are the causative factor. These marks normally appear during the third trimester of pregnancy and disappear several months after delivery. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Feb 12;233:49-52. Epub 2018 Dec 12.

Zekai Tahir Burak Woman's Health Education and Research Hospital, Ankara, Turkey.

Objective(s): To investigate the association between striae gravidarum and low back pain in pregnancy.

Study Design: 200 healthy pregnant women with first, uncomplicated and singleton pregnancy at a gestation age of 36-37 weeks were evaluated for striae gravidarum Davey score. Back pain was assessed by Visual Analogue Scale and functional disability by the Turkish version of Oswestry Disability Index. Read More

Lasers Surg Med 2019 03 27;51(3):230-238. Epub 2018 Nov 27.

Department of Plastic, Reconstructive and Maxillo facial Surgery, Hopital Henri Mondor, Creteil, 94010, France.

Background And Objective: Striae distensae (SD) are cutaneous lesions that often occur on the breasts, abdomen, hips, and thighs. The aim of this study is to evaluate the effectiveness of a new technique using a non-invasive Er:YAG laser combined with Spatially Modulated Ablation (SMA) module for the treatment of SD.

Study Design/materials And Methods: This prospective pilot clinical study included 20 patients with skin phototypes I to IV who are affected by SD. Read More

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

Skin Res Technol 2019 May 22;25(3):283-288. Epub 2018 Oct 22.

Clinical Research Center, Institut d'Expertise Clinique (IEC) Korea, Suwony, Gyeonggi-do, Korea.

Background: Striae distensae are common dermal lesions that progress through two different stages: the striae rubra, which appears to be erythematous, and striae alba, which is characterized by a hypopigmented feature. The clinical characteristics between striae distensae stages and normal skin remain unknown.

Objectives: We aimed to investigate the clinical characteristics according to stages of striae distensae in terms of their biophysical properties, using objective noninvasive measurements in comparison with adjacent normal skin. Read More

J Cosmet Laser Ther 2019 Aug 15;21(5):270-277. Epub 2018 Oct 15.

c Faculty of Medicine , Cairo University , Egypt.

: Fractional photothermolysis is creation of microscopic thermal zones of controlled depth, width and density. Microneedling is a simple treatment modality to reduce striae distensae. : Evaluate and compare the efficacy of fractional carbon dioxide laser and microneedling as a treatment of striae distensae. Read More

Trials 2018 Oct 12;19(1):553. Epub 2018 Oct 12.

School of Nursing & Midwifery, Aras Moyola, National University of Ireland Galway, Galway, H91 TK33, Ireland.

Background: Striae gravidarum (stretch marks) are considered the most common connective tissue/skin change in pregnancy. Though not a health issue they can affect women in different ways, for example, cause stress or be an aesthetic or cosmetic concern. Many women use one or more of the commercially available products to try and prevent their development during pregnancy despite the fact that that there is a lack of high-quality evidence to support their use. Read More

Minerva Ginecol 2018 Oct;70(5):629-634

IRVINE3 Labs, Department of Medical and Oral Sciences, and Biotechnologies, G. D'Annunzio University, Chieti, Italy.

Background: This registry study evaluates the effects of oral Centellicum®, a new preparation of Centella asiatica (CA) on cutaneous stretchmarks (SMs) on the lower abdominal wall in comparison with the topical treatment with a specific antistretch cream. This cream is used for pregnancy SMs. The aim of the management was to give back to the structurally damaged skin areas (apparent as SMs) a normal elasticity and resistance and improving the local microcirculation. Read More

Dermatol Ther 2019 01 21;32(1):e12750. Epub 2018 Oct 21.

Department of Dermatology, Virgen del Rocio University Hospital, Seville, Spain.

J Eur Acad Dermatol Venereol 2019 Jan 8;33(1):220-226. Epub 2018 Oct 8.

Clinic of Dermatology and Allergy, Department for Aesthetic Dermatology and Laser Medicine, Ludwig-Maximilian-University, Munich, Germany.

Background And Objective: Striae distensae (SD) represent therapeutically challenging forms of dermal atrophic scarring. In addition to topical ointments, medical needling and various energy-based devices, non-ablative fractional lasers have been suggested for their improvement. However, objective evaluations of their efficacy are widely missing. Read More

Dermatol Ther 2018 09 28;31(5):e12699. Epub 2018 Aug 28.

Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland.

Carbon dioxide is a physiologic compound present in our body, mainly as a result of cellular metabolism. The frequency of carboxytherapy use by dermatologists and cosmetologists increased significantly in the second half of the 20th century due to the fact that it improves blood circulation within skin tissues. This article focuses on the use of carboxytherapy in case of various skin problems, such as stretch marks, scars, loss of elasticity, redundancy of fatty tissue, cellulite, morphea, and alopecia. Read More

J Cosmet Laser Ther 2019 21;21(4):213-216. Epub 2018 Aug 21.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II , Naples , Italy.

Striae distensae or stretch marks are dermal scars characterized by flattening and atrophy of the epidermis. They develop particularly during adolescence but they can also appear in other situations such as pregnancy, the use of prolonged therapies with topical or systemic corticosteroids, Cushing's syndrome, Marfan's syndrome, prolonged use of lightening creams, cachexia, rapid weight loss or the use of androgenic and anabolic substances. Treatment options often take a long time, and the results are often disappointing, causing significant psychological distress in patients. Read More

J Dermatolog Treat 2019 May 7;30(3):294-302. Epub 2018 Sep 7.

c Department of Dermatologic Surgery and Laser Unit, St. John's Institute of Dermatology , St. Thomas' Hospital , London , UK.

Background: Striae distensae are caused by rapid stretching of the skin. They are often secondary to obesity or pregnancy and can lead to significant cosmetic disfigurement.

Aim: To determine the efficacy, indications, and side effects of commonly used energy devices in the treatment of striae. Read More

Australas J Dermatol 2019 Feb 26;60(1):78-80. Epub 2018 Jul 26.

Women's and Children's Hospital, Adelaide, South Australia, Australia.

Pak J Med Sci 2018 May-Jun;34(3):568-573

YaseminTasci, Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care Training and Research Hospital, Ankara, Turkey.

Objective: To evaluate the relationship between striae gravidarum (SG) score and abdominal scar characteristics together with intraperitoneal adhesion (IPA) grades of patients who were hospitalized for second cesarean delivery.

Methods: A total of 145 consecutive women undergoing scheduled cesarean section (CS) in a tertiary level maternity hospital between November 2013 and January 2014 were included in the study. All women had transverse suprapubic skin incision due to the previous CS and none of them had a history of vaginal delivery. Read More

Int J Dermatol 2018 10 18;57(10):e82-e83. Epub 2018 Jul 18.

Department of Anatomic Pathology, Hospital Universitario Virgen Macarena, Seville, Spain.

J Cosmet Laser Ther 2018 Oct 6;20(6):330-334. Epub 2018 Jul 6.

c Medical laser Research Group, Medical Laser Research Center, ACECR , Tehran , Iran.

Striae distensae (SD) are atrophic dermal scars often found on abdomen, breasts, thighs, and hips of pregnant women. The strias' self-healing without any intervention is a poor possibility. Till now, several lasers and light sources have been used for treatment of SD. Read More