Search Our Scientific Publications & Authors

Clin Dermatol 2022 May-Jun;40(3):305-309. Epub 2021 Aug 20.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany. Electronic address:

Carboxytherapy is a medical technique during which a sterile gas-carbon dioxide-is injected into the subdermal tissue. The utility of carbon dioxide injections has enhanced the practical relevance of carboxytherapy as a method for the management of multiple disorders. We have evaluated its use in the treatment of dermatologic conditions by searching electronic databases (ie, MEDLINE and PubMed) for contributions in the English language through January 2021. Read More

Plast Reconstr Surg 2022 Jun 6. Epub 2022 Jun 6.

Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine, Stanford, California, USA.

Introduction: Striae distensae (SD) are common disfiguring cutaneous lesions but lack effective treatments due to an incomplete understanding of their pathophysiology. Dermal fibroblasts likely play an important role. We investigate the cellular-molecular features distinguishing fibroblasts from human SD and normal skin (NS). Read More

Int J Dermatol 2022 May 11. Epub 2022 May 11.

Michigan State University, College of Osteopathic Medicine, Macomb University Center, Clinton, Michigan, USA.

Objective: This manuscript provides a review of the relationship between patients with an underlying eating disorder (ED) and the presence of striae distensae (SD). Researchers and clinicians have recognized many different skin manifestations associated with EDs. According to the Diagnostic and Statistical Manual of Mental Disorders, EDs include, but are not limited to, anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Read More

Bioengineering (Basel) 2022 Mar 25;9(4). Epub 2022 Mar 25.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

A large part of the world's population suffers from Striae distensae (SD) or stretch marks, which create physical and psychological discomfort in people. We evaluate the SD clinical improvement by using a non-ablative fractional Nd:YAP 1340 nm laser. The research was performed on 25 patients of both sexes, with a mean age of 31 ± 13. Read More

Indian J Pharmacol 2022 Jan-Feb;54(1):63-64

Department of Dermatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

PLoS One 2022 15;17(3):e0265149. Epub 2022 Mar 15.

Pediatric Dermatology Services, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective: Striae gravidarum (SG) and perineal lacerations are common occurrences during late pregnancy and labor. It has been hypothesized that both conditions may share a common pathophysiological pathway through changes in the connective tissue. We aimed to investigate a possible association between these two conditions and whether the presence of SG may predict perineal lacerations. Read More

Pediatr Dermatol 2022 Mar 14. Epub 2022 Mar 14.

Department of Dermatology, Aydın Adnan Menderes University Faculty of Medicine, Aydın, Turkey.

Background: Cutaneous changes in obese adults have been investigated in numerous studies, but this issue has not been adequately investigated in children.

Objectives: We aimed to determine the prevalence of skin manifestations in children with obesity by comparing them to normal-weight children.

Methods: A cross-sectional study was conducted between June 2017 and January 2019 in which 82 children with obesity and 86 normal-weight healthy control children were enrolled. Read More

Molecules 2022 Feb 14;27(4). Epub 2022 Feb 14.

Biospectrum, Life Science Institute, Yongin-si 16827, Korea.

Striae distensae (SD) or stretch marks are common linear scars of atrophic skin with disintegrating extracellular matrix (ECM) structures. Although fibroblasts contribute to the construction of ECM structure in SD, some studies have reported that mast cell degranulation causes the disruption of ECM in early SD lesions. flower (LIF) has traditionally been used in India as a diuretic. Read More

Int J Mol Sci 2022 Feb 1;23(3). Epub 2022 Feb 1.

Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.

Chondroitin obtained through biotechnological processes (BC) shares similarities with both chondroitin sulfate (CS), due to the dimeric repetitive unit, and hyaluronic acid (HA), as it is unsulfated. In the framework of this experimental research, formulations containing BC with an average molecular size of about 35 KDa and high molecular weight HA (HHA) were characterized with respect to their rheological behavior, stability to enzymatic hydrolysis and they were evaluated in different skin damage models. The rheological characterization of the HHA/BC formulation revealed a G' of 92 ± 3 Pa and a G″ of 116 ± 5 Pa and supported an easy injectability even at a concentration of 40 mg/mL. Read More

J Lasers Med Sci 2021 9;12:e57. Epub 2021 Oct 9.

Department of Medical Applications of Laser in Dermatology, NILES, Cairo, Egypt.

Stretch marks, or striae distensae (SD), are the lesions of the dermis caused by its linear atrophy at the sites of stretching. They occur in more than 70% of pregnant women and adolescents as a result of cutaneous stretching. This study aimed at evaluating and comparing the clinical and histological efficacy of the fractional CO laser versus the long pulsed (LP) Nd: YAG laser in the treatment of striae alba. Read More

J Cosmet Dermatol 2022 May 14;21(5):1874-1894. Epub 2022 Feb 14.

Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: The overall effects of Carboxytherapy, defined as the administration of carbon dioxide, have been studied for many years. It has been suggested that by improving oxygenation, interacting with the tissue perfusion regulators, and disrupting the adipose cell membranes, the method can lead to notable improvements in different esthetic and pathological conditions. Therefore, we aimed to systematically review the available studies evaluating the potential benefits of carboxytherapy in dermatological conditions and how it objectively stands against scientific scrutiny. Read More

Turk Arch Pediatr 2021 Sep;56(5):447-450

Department of Dermatology, Istanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, Istanbul, Turkey.

Objectives: Striae distensae (SD) are characterized by erythematous or atrophic bands, which are common during adolescence and can adversely impact the psychosocial status of the affected patients. Our aim in this study is to evaluate the quality of life of children and adolescents diagnosed with SD.

Methods: This prospective observational study included 50 adolescents with SD. Read More

J Cosmet Dermatol 2022 Jan 25. Epub 2022 Jan 25.

Department of Dermatology, Jose R. Reyes Memorial Medical Center, Manila, Philippines.

Background: Striae gravidarum (SG) is a connective tissue disorder seen commonly in primigravidas. It is associated with impairment in the quality of life.

Objective: To determine the efficacy of ablative fractional carbon dioxide (CO ) laser combined with autologous platelet-rich plasma (PRP) versus ablative fractional CO  laser and placebo in the treatment of SG. Read More

J Cosmet Dermatol 2022 Jan 17. Epub 2022 Jan 17.

Dermatology & STD and Andrology Department, Faculty of Medicine, Fayoum University, Egypt.

Background: Striae distensae (SD) or stretch marks, a common condition causing significant cosmetic concern and distress, are linear dermal scars associated with epidermal atrophy that occur due to overstretching. Recently, micro-needling with dermapen is considered as one of the therapeutic modalities for SD. Also, plasma skin regeneration with plasma jet has been recommended as an effective method for the treatment of SD. Read More

Int J Womens Dermatol 2021 Dec 3;7(5Part B):685-691. Epub 2021 Nov 3.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan.

Background: The impact of striae gravidarum (SG), or stretch marks of pregnancy, on quality of life (QoL) is unclear.

Objective: The purpose of this study was to investigate how SG affect QoL in pregnant women.

Methods: In this cross-sectional survey study of healthy pregnant women who developed SG during their current pregnancy, we asked about the impact of lesions on emotional, psychological, and life-quality facets. Read More

Cureus 2021 Nov 14;13(11):e19561. Epub 2021 Nov 14.

Dermatology, College of Medicine, King Saud University (KSU), Riyadh, SAU.

Background Striae distensae (SD) or stretch marks are a common dermatological condition where the dermis becomes scarred. This phenomenon is associated with many risk factors. This study aimed to evaluate the clinical variables and risk factors in patients with SD in Riyadh, Kingdom of Saudi Arabia (KSA). Read More

Dermatol Ther 2022 02 16;35(2):e15245. Epub 2021 Dec 16.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Striae distensae (SD) are disfiguring skin condition causing cosmetic troubles and psychological distress. The aim was to compare the efficacy and safety of platelet-rich plasma (PRP) versus its combination with subcision or medium-depth peeling (glycolic acid 70% followed by trichloroacetic acid [TCA] 35%) for SD treatment. Seventy-five female patients with SD were divided into three equal groups with the contralateral side in each patients represented the control group. Read More

Dermatol Ther 2022 01 30;35(1):e15212. Epub 2021 Nov 30.

Molecular Dermatology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.

Striae distensae (SD) are common skin conditions that have posed a significant challenge regarding their assessment and treatment. The present study aimed to evaluate the efficacy of microneedling in comparison to fractional CO laser therapy. Similar striae were selected and photographed. Read More

Biomed Eng Online 2021 Oct 25;20(1):109. Epub 2021 Oct 25.

College of Information and Communication Engineering, Nanjing Institute of Technology, Hongjing Avenue 1, Nanjing, Jiangsu, China.

Background: Striae gravidarum is a common occurrence in pregnancy and many women expect to prevent its development. At present, laser treatment has been used to improve the appearance of striae gravidarum, but the choice of laser type, treatment time, and frequency depend on the therapeutic effect. How to obtain an effective evaluation of striae gravidarum during and after treatment is very important. Read More

Aesthetic Plast Surg 2021 Oct 4. Epub 2021 Oct 4.

Department of Plastic, Reconstructive and Maxillo facial Surgery, Henri Mondor Hospital, University Paris XII, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.

Authors present a study about the contraction forces observed in striae distensae fibroblasts (SMF) in a collagen scaffold. Collagen lattices were used to study the mechanical behavior of SDF within the collagen matrix compared to the lattices produced using the healthy skin derived fibroblasts (NSF). A Forcebox device was used to measure the contractile forces. Read More

J Cosmet Dermatol 2022 Feb 26;21(2):859-864. Epub 2021 Sep 26.

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Altern Ther Health Med 2022 May;28(4):34-39

Context: The development of striae gravidarum (SG), stretch marks, is one of the most common skin changes during pregnancy. The number of studies conducted on the reduction or prevention of SG, especially on the effects of olive oil, is limited.

Objective: The study intended to evaluate the clinical efficacy of olive oil in reducing the severity and preventing the progression of SG when used from the third trimester of pregnancy to the child's birth. Read More

J Cosmet Laser Ther 2021 May 14;23(3-4):81-86. Epub 2021 Sep 14.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Teaching Hospital, Surabaya, Indonesia.

Striae distensae (SD) are linear scar tissue in the dermis that arises from stretching the skin. There are two types of SD, striae rubrae and striae albae (SA) which is marked with a line hypopigmentation that cause a psychological problem, especially in the high skin type. The standard therapy is a 0. Read More

J Formos Med Assoc 2022 Jun 26;121(6):1093-1101. Epub 2021 Aug 26.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: Thoracic aortic aneurysm and dissection (TAAD) is a devastating but treatable disease if detected early. The clinical manifestations and genetic characteristics underlying TAAD patients in Taiwan, however, remain unclear.

Methods: We consecutively recruited patients referred for TAAD screening and/or management at a tertiary medical center in Taiwan. Read More

Lasers Surg Med 2022 01 22;54(1):129-137. Epub 2021 Aug 22.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Striae distensae are atrophic dermal scars that can cause psychosocial distress among affected patients. Despite numerous available therapeutic modalities, no gold standard treatment has been established.

Objective: To evaluate the long-term efficacy and safety of a fractional 1064-nm picosecond laser for the treatment of striae alba in individuals with dark skin types. Read More

Exp Dermatol 2022 02 9;31(2):182-190. Epub 2021 Aug 9.

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Although the long-term use of topical glucocorticoids (TGC) may induce skin atrophy including striae distensae (SD), patients with atopic dermatitis (AD) appear to have lesser degree of skin atrophy than those with psoriasis (PSO). Periostin, encoded by POSTN, is involved in tissue remodelling processes of chronic AD lesions. This study was designed to investigate the difference in the occurrence of skin atrophy in patients with AD or PSO when treated with TGC and to elucidate the association between skin atrophy and periostin. Read More

West Afr J Med 2021 Jul;38(7):667-673

Department of Dermatology & Venereology, Obafemi Awolowo University and OAUTHC, Ile-Ife, Nigeria.

Background: Striae distensae is a common affliction of darkly pigmented skin. The pattern, risk factors and impact of striae distensae on the Quality of Life (QoL) have not been widely examined.

Objective: To document the prevalence, pattern, risk factors and impact of striae distensae on the QoL of sufferers. Read More

Dermatol Surg 2021 10;47(10):1408-1410

Laser and Skin Surgery Center of New York, New York, New York.

Dermatol Surg 2021 10;47(10):1407-1408

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

Biomed Opt Express 2021 Jun 11;12(6):3296-3311. Epub 2021 May 11.

Department of Electronic and Electrical Engineering, University of Sheffield, Sir Frederick Mappin Building, Sheffield, S1 3JD, UK.

Stretch marks or striae distensae (SD) cause emotional distress and negatively affect the psychological well-being of patients. We investigate and compare two methods for quantifying the severity of SD: visual scoring of images captured using a clinical visible-light dermatological camera (C-Cube, Pixience Inc) and measuring the local birefringence of skin using polarization-sensitive optical coherence tomography (PS-OCT). Data on skin visually affected by SD and visually normal skin were collected from 19 human volunteers. Read More