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Cell Physiol Biochem 2018 Dec 6;51(5):2085-2097. Epub 2018 Dec 6.

Background/aims: Diabetic nephropathy is a common complication of diabetes. This study explored the renal protective effect and possible mechanism of gliquidone in mice with diabetic nephropathy.

Methods: Animal model of diabetic nephropathy was established in KKAy mice. Read More

J Mech Behav Biomed Mater 2018 Nov 12;90:673-680. Epub 2018 Nov 12.

Faculty of Odontology, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. Electronic address:

This study evaluated the fatigue failure load, number of cycles for failure and survival probability of 2nd and 3rd generation yttrium-stabilized zirconia (YSZ) adhesively cemented to a dentin analogue substrate. Disc-shaped specimens (n = 10; Ø = 10 mm; thickness = 1.0 mm) were produced from four 2nd generation YSZs (Lava Plus, 3M ESPE; Vita In-Ceram YZ-HT, VITA Zahnfabrik; Zirlux FC, Ivoclar Vivadent; Katana ML-HT, Kuraray) and two 3rd generation YSZs (Katana UTML and Katana STML, Kuraray). Read More

J Adolesc 2018 Dec 3;70:43-52. Epub 2018 Dec 3.

York University, 5022 TEL, 4700 Keele St., Toronto ON, M3J 1P3, Canada. Electronic address:

Introduction: This study examined romantic relationships among street-involved youth through the overlapping perspectives of resilience, attachment and social bonding. The main goal was to assess how youth understand their romantic attachment bonds as supporting or undermining resilience. While there are qualitative reports on how the social relationships of street-involved youth are linked to resilience, romantic relationships have yet to be differentiated with regard to resilience. Read More

Infant Behav Dev 2018 Dec 3;54:22-36. Epub 2018 Dec 3.

University of Tennessee, Department of Child and Family Studies, 1215 W. Cumberland Ave Knoxville, TN 37996, USA. Electronic address:

Parents' exposure to stressful ecosocial situations, like inadequate resources, is linked to parents' perceptions of infants' fussing and crying and less sensitive caregiving. However, studies supporting these findings predominantly come from Western contexts of parenting and infant care. Ecosocial situations may have different effects on parenting and infants in distinct cultural contexts. Read More

Psychoneuroendocrinology 2018 Nov 30;102:63-67. Epub 2018 Nov 30.

Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, D-54290, Trier, Germany. Electronic address:

Secretion of the stress hormone cortisol follows a circadian rhythm and is stimulated following stress exposure. Cortisol regulates the transcription of several genes, primarily through activation of the glucocorticoid receptor (GR). Previously, we showed an upregulation of PERIOD genes PER1 and PER3 after pharmacological/glucocorticoid challenge in vivo and in vitro. Read More

Curr Opin Psychol 2018 Nov 22;28:76-80. Epub 2018 Nov 22.

Faculty of Health Sciences, Universitat Oberta de Catalunya, Av. Tibidabo, 39-43, 08035, Barcelona, Spain; Honorary Fellow, Center for Healthy Minds, University of Wisconsin-Madison, United States. Electronic address:

In the last decade, epigenetics has taken center stage to explain the relationships between stress exposure, health and behavior. Acquired or inherited epigenetic changes modulate gene expression states without modifying the DNA sequence itself, they can be long-lasting, yet, they are potentially reversible. Several studies have explored whether meditation-based interventions can influence gene expression profiles towards healthier directions, identifying candidate genes and biological pathways that seem to be sensitive to contemplative practices. Read More

J Psychiatr Res 2018 Nov 27;109:107-117. Epub 2018 Nov 27.

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105-900, Santa Maria, Rio Grande do Sul, Brazil. Electronic address:

Alzheimer 's disease (AD) is characterized by progressive cognitive decline including memory impairment, cortical dysfunction, and neuropsychiatric disturbances. The drug discovery to treat AD consists to develop compounds able to act in multiple molecular targets involved in the pathogenesis of the disease and the repositioning of old drugs for new application. This way, the intracerebroventricular (icv) injection of streptozotocin (STZ) has been used as a metabolic model of sporadic AD. Read More

Aquat Toxicol 2018 Nov 27;207:52-62. Epub 2018 Nov 27.

Josip Juraj Strossmayer University of Osijek, Department of Biology, Ulica cara Hadrijana 8/A, HR-31000, Osijek, Croatia. Electronic address:

This paper aims to evaluate the effects of a product containing colloidal silver in the aquatic environment, using duckweed Lemna gibba as a model plant. Therefore, growth parameters, photosynthetic pigments content and protein content as physiological indices were evaluated. Changes in the content of non-enzymatic antioxidants and activity of several antioxidant enzymes, alongside with the accumulation of hydrogen peroxide and lipid peroxidation end-products were assessed to explore the potential of colloidal silver to induce oxidative stress. Read More

Eur J Pharm Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands. Electronic address:

The aim of this study was to identify critical steps to protein stability during spray drying using two different nozzle types: a vibrating mesh nozzle and a standard two-fluid nozzle in a Büchi B-90 spray dryer. l-Lactic dehydrogenase was used as a model protein as it is a heat and shear stress sensitive protein. Trehalose was used as excipient because of its excellent stabilizing capacities. Read More

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 3. Epub 2018 Dec 3.

Lipids and Atherosclerosis Research Unit, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Universitat Rovira i Virgili, Reus, Spain. Electronic address:

Aims: The aim of this study is to determine the physical and functional interplay between fatty acid-binding protein 4 (FABP4) and its membrane receptor-like candidate protein, cytokeratin 1 (CK1), and to determine the effect of hindering CK1-mediated FABP4 cellular uptake on non-disturbed or metabolically stressed endothelial cells.

Methods: We monitored the direct interaction between FABP4 and CK1 using surface plasmon resonance, and the effects of blocking exogenous FABP4 (eFABP4) cellular uptake were determined by using specific siRNA to knock down the expression of CK1 in human umbilical vein endothelial cells (HUVECs). The expression and nuclear translocation of transcription factors involved in oxidative stress (NRF2) and inflammation (p65 subunit of NF-ĸB transcription factor) were determined by Western blotting analysis. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

University of Sfax Tunisia, Faculty of Sciences, Department of Life Sciences, Laboratory of Biodiversity and Aquatic Ecosystems, Ecology and Planktonology, Unit UR 11 ES 72/Street of Soukra Km 3,5, B.P. 1171, CP 3000 Sfax, Tunisia.

Periploca angustifolia has numerous biological properties and also used against various diseases. In our study, this plant has been used for biotechnological production of polysaccharides. The prevention action of polysaccharides isolated from P. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health in Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China. Electronic address:

Codonopsis pilosula polysaccharides (CPPS) has been shown to possess a variety of biological activities. In previous study, CPPS was successfully modified to obtain its best selenizing Codonopsis pilosula polysaccharides (sCPPS). The purpose of this study was to investigate the protective effect of the selenizing derivative of CPPS (sCPPS) from HO-induced oxidative damage in RAW264. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of life sciences, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Thiol Protease inhibitors (cystatins) are endogenous natural inhibitors of cysteine proteases. They are present in all mammalians cells and body fluids. Cystatin are allocated into three major families. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, PR China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu 214122, PR China. Electronic address:

In present study, the in vitro and in vivo hemolysis inhibitory, protective effect against reactive oxygen species (ROS) induced oxidative damage in L02 cells, hypoglycemic, and antiglycation activities of DJP-2, a pure polysaccharide fraction from Diaphragma juglandis fructus, were investigated. Results demonstrated that DJP-2 showed remarkable hemolysis inhibitory activity. Pretreatment with DJP-2 markedly weakened the oxidative damage induced by HO in hepatic L02 cells via strengthening the cell viability. Read More

Pharmacol Biochem Behav 2018 Dec 3. Epub 2018 Dec 3.

New York State Psychiatric Institute, New York, NY, United States of America; Columbia University Medical Center, New York, NY, United States of America.

Cannabis is the most widely used illicit drugs and the changing legal, political and cultural climate will likely increase cannabis use further. One factor that may underlie the transition from recreational use to problematic use is stress. The hormone oxytocin (OXT) modulates stress and may have therapeutic efficacy for substance use disorders, but few studies have examined OXT in cannabis users. Read More

Neuropharmacology 2018 Dec 3. Epub 2018 Dec 3.

Program of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.

A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it was described that N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (ALDA-1) activates aldehyde dehydrogenase-2 (ALDH2), enzyme that catalyzes the oxidation of ethanol-derived acetaldehyde to acetate. The aim of this study was to determine the effects of ALDA-1 on both the acquisition and the maintenance of alcohol intake in alcohol-preferring UChB rats. Read More

Exp Mol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Universidade Luterana do Brasil - ULBRA - Graduate Program in Genetics and Applied Toxicology, Canoas, Rio Grande do Sul, Brazil; Universidade Luterana do Brasil - ULBRA - Graduate Program in Cellular and Molecular Biology Applied to Health, Canoas, Rio Grande do Sul, Brazil; Universidade Federal do Rio Grande do Sul - UFRGS - Graduate Program in Medicine: Medical Sciences, Porto Alegre, Rio Grande do Sul, Brazil; Universidade Luterana do Brasil - Laboratory of Oxidative Stress and Antioxidants, Canoas, Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre - HCPA - Laboratory of Experimental Hepatology and Gastroenterology, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

In recent decades, the number of people who practice sports has grown exponentially, increasing the number of muscular injuries. Trauma injury occurs when the muscle is exposed to a sudden compression force. Melatonin (MLT) has often been cited in the literature as a potent antioxidant and anti-inflammatory agent. Read More

Exp Neurol 2018 Dec 3. Epub 2018 Dec 3.

Cellular Neurobiology Laboratories, The Salk Institute, La Jolla, CA, USA.

Ischemic stroke is an acute neurodegenerative disease that is extremely devastating to patients, their families and society. Stroke is inadequately treated even with endovascular procedures and reperfusion therapy. Using an extensive translational screening process, we have developed a pleiotropic cytoprotective agent with the potential to positively impact a large population of brain ischemia patients and revolutionize the process used for the development of new drugs to treat complex brain disorders. Read More

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Critical Care Medicine, Guangzhou, Guangdong, China.

Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS).

Objective: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS.

Methods: Lung proteome was profiled in three models of injury induced by acid instillation and/or mechanical ventilation in mice. Read More

FASEB J 2018 Dec 6:fj201801463R. Epub 2018 Dec 6.

Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC) Unité Mixte de Recherche (UMR) 7178, Université de Strasbourg, Strasbourg, France.

Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronaut's health and safety. However, consequences on B-cell development and responses are still under-investigated. To fill this gap, we used advanced proteomics analysis of femur bone and marrow to compare mice flown for 1 mo on board the BION-M1 biosatellite, followed or not by 1 wk of recovery on Earth, to control mice kept on Earth. Read More

Acta Ortop Mex 2018 May-Jun;32(3):163-166

Servicio de Cirugía Ortopédica y Traumatología, Hospital de Sabadell. Institut Universitari Parc Taulí Universitat Autònoma de Barcelona, España.

We present the case of an 81-year-old woman who was followed up by the Rheumatology Service for osteoporosis and treated with bisphosphonates for more than five years. She reported a fracture of the distal third of the contralateral femur by a low energy mechanism, treated with retrograde intramedullary nailing the previous year. She presented a clinic of cruralgia and left gonalgia, without previous trauma. Read More

Acta Biochim Pol 2018 Dec 6. Epub 2018 Dec 6.

Uniwersytet Gdański Wydział Chemii Katedra Biotechnologii Molekularnej ul. Wita Stwosza 63 80-308 Gdańsk.

Supplementing the human microbiome with probiotic microorganisms is a proposed solution for civilization syndromes such as dysbiosis and gastrointestinal tract (GIT) disorders. Bimodal probiotic strains of the Bacillus genus constitute the microbiota of the human environment, and are typically found in soil, water, a number of non-dairy fermented foods, as well as in human and animal GIT. Probiotic Bacillus sp. Read More

PLoS One 2018 6;13(12):e0208571. Epub 2018 Dec 6.

Haaglanden Medical Center, The Hague, the Netherlands.

Aim: Increasing evidence exists with respect to the relation between stressful life events and functional constipation (FC). We aimed to investigate the prevalence of FC in Palestinian refugee preschool children and to determine if stress and trauma exposure are risk factors of FC in these children.

Methods: From November 2013 until May 2014, a cross-sectional survey was conducted in West Bank, Gaza and Jordan. Read More

PLoS One 2018 6;13(12):e0208575. Epub 2018 Dec 6.

School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.

Background: A key mechanism thought to underlie Posttraumatic Stress Disorder (PTSD) is enhanced emotional memory consolidation. Recent evidence in healthy controls revealed that women have greater negative memory consolidation following stress relative to men. This study examined emotional memory consolidation in women and men with PTSD, and in trauma-exposed and non-trauma controls to test the hypothesis that emotionally negative memory consolidation would be greater in women with PTSD. Read More

PLoS One 2018 6;13(12):e0208438. Epub 2018 Dec 6.

Department of Psychology, Illinois State University, Normal, Illinois, United States of America.

Posttraumatic stress-negative psychological experiences as a result of traumatic stressors-can hinder military veterans' reintegration into society and cause various mental health problems. Veterans need quality social relationships to facilitate reintegration and to cope with posttraumatic stress and related mental health problems; discrimination or other forms of interpersonal rejection can exacerbate these veterans' problems. Ostracism (i. Read More

PLoS One 2018 6;13(12):e0208201. Epub 2018 Dec 6.

Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan, India.

Development of antifilarial drug from the natural sources is considered as one of the most efficacious, safe, and affordable approaches. In this study, we report the antifilarial activity of a leguminous plant Cajanus scarabaeoides (L.) Thouars. Read More

J Phys Condens Matter 2019 Jan;31(2):025401

Materials Science Program, School of Mechanical, Industrial and Manufacturing Engineering, Oregon State University, Corvallis, OR 97331, United States of America.

Nanoscale metallic glasses (MGs) are frequently used in experimental and computational studies to probe the deformation mechanisms in amorphous metals. Potential consequences of the significant surface to volume ratio in these extremely small materials, nevertheless, are not well understood. Here, using molecular dynamics simulations and novel selective 3D visualization, we show that significant irreversible atomic shear strain condenses on the 3D surface of these materials under low uniaxial stress, while the interior atoms are bearing much lower, mostly reversible shear strain. Read More

Rom J Intern Med 2018 Dec;56(4):257-264

Kharkiv National Medic University, Nauky Ave., Kharkiv, Ukraine.

Introduction: Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. Read More

Acta Med Port 2018 Nov 30;31(11):633-640. Epub 2018 Nov 30.

Centro de Investigação em Psicologia. Escola de Psicologia. Universidade do Minho. Braga. Portugal.

Introduction: Bariatric surgery is the most effective method for the treatment of morbid obesity. However, the development of eating psychopathology and the emergence of problematic eating behaviours have been reported in the literature. The aim of this crosssectional study was to characterize the post-bariatric population in terms of the frequency of problematic eating behaviours over time and to understand the related psychological features. Read More

Med J Aust 2018 Dec;209(11):495-500

Oxford University, Oxford, United Kingdom.

Objectives: To describe the patterns of alcohol use in James Bond movies over six decades.

Design: Film content analysis.

Setting: Wide range of international locations in 24 James Bond movies (Eon Productions series, 1962-2015). Read More

FASEB J 2018 Dec 6:fj201800885RR. Epub 2018 Dec 6.

Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Protein tyrosine (Tyr) nitration, the covalent addition of a nitro group (NO) to Tyr residues, is emerging as a candidate mechanism of endothelial dysfunction. Previous studies have shown that Tyr nitration is primarily induced by nitrosative stress, a process characterized by the production of reactive nitrogen species, especially peroxynitrite anion (ONOO), which is considered a secondary product of NO in the presence of superoxide radicals (O). However, the impact of nitrosative stress-induced Tyr nitration on endothelial dysfunction has not been thoroughly elucidated to date. Read More

FASEB J 2018 Dec 6:fj201800981R. Epub 2018 Dec 6.

Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

As mechanisms controlling redox homeostasis become impaired with aging, exaggerated oxidant stress may cause disproportional oxidation of cell membranes and circulating phospholipids (PLs), leading to the formation of truncated oxidized PL products (Tr-OxPLs), which exhibit deleterious effects. This study investigated the role of elevated Tr-OxPLs as a factor exacerbating inflammation and lung barrier dysfunction in an animal model of aging. Mass spectrometry analysis of Tr-OxPL species in young (2-4 mo) and aging (18-24 mo) mice revealed elevated basal levels of several products [1-palmitoyl-2-(5-oxovaleroyl)- sn-glycero-phosphocholine (POVPC), 1-palmitoyl-2-glutaroyl- sn-glycero-phosphocholine, lysophosphocholine, 1-palmitoyl-2-(9-oxo-nonanoyl)- sn-glycero-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-glycero-3-phosphocholine, O-1-O-palmitoyl-2-O-(5,8-dioxo-8-hydroxy-6-octenoyl)-l-glycero-3-phosphocholine, and others] in the aged lungs. Read More

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Miami, Kinesiology and Sport Sciences, Coral Gable, Florida, United States ;

The presence of postganglionic sympathetic denervation is well established in Parkinson's disease (PD). Denervation at cardiac and blood vessel sites may lead to abnormal cardiovascular and hemodynamic responses to exercise. The aim of the present investigation was to examine how heart rate (HR) and hemodynamics are affected by an exercise test in PD patients without orthostatic hypotension. Read More

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Manitoba, Food and Human Nutritional Sciences, Winnipeg, Manitoba, Canada.

Prenatal ethanol (EtOH) exposure is known to induce adverse effects on fetal brain development. Docosahexaenoic acid (DHA) has been shown to alleviate these effects by upregulating antioxidant mechanisms in the brain. The liver is the first organ to receive enriched blood after placental transport; therefore, it could be negatively affected by EtOH, but no studies have assessed the effects of DHA on fetal liver. Read More

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Neuro-Urology, CTO - Spinal Unit, Città della Salute e della Scienza di Torino, Turin, Italy.

Purpose: The aim of our study is to evaluate the efficacy and safety of ATOMS® system for the treatment of postoperative male stress urinary incontinence (SUI).

Materials And Methods: We retrospectively evaluated all patients treated at our institution for postoperative male SUI with ATOMS® implant. We excluded patients with low bladder compliance (< 20 mL / cmH2O), uncontrolled detrusor overactivity, detrusor underactivity (BCI < 100), urethral or bladder neck stricture and low cystometric capacity (< 200 mL). Read More

Depress Anxiety 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Background: Major depressive disorder (MDD) in college students is associated with substantial burden.

Aims: To assess 1-year incidence of MDD among incoming freshmen and predictors of MDD-incidence in a representative sample of students.

Method: Prospective cohort study of first-year college students (baseline: n = 2,519, 1-year follow-up: n = 958) RESULTS: The incidence of MDD within the first year of college was 6. Read More

Mol Nutr Food Res 2018 Dec 6:e1800807. Epub 2018 Dec 6.

Dr. X. Yan, Y.-L. Zhang, L. Zhang, L.-X. Zou, C. Chen, Prof. Y. Liu, Prof. Y.-L. Xia, Prof. H.-H. Li, Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian, 116044, China.

Scope: Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits antioxidative and anti-inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; however, whether GA attenuates pressure overload-induced cardiac hypertrophy and the underlying mechanism remain unclear. Read More

J Anim Ecol 2018 Dec 6. Epub 2018 Dec 6.

Department of Biology, Utah State University, Logan, Utah, USA.

1.Oxidative stress is a potential cost of reproduction, but conclusive evidence for this relationship is lacking. The goal of this study was to serially assess across a seasonal gradient the relationship between reproduction, circulating plasma energy metabolites, and oxidative state. Read More

Arch Clin Neuropsychol 2018 Dec 6. Epub 2018 Dec 6.

VA San Diego Healthcare System (VASDHS); San Diego, CA, USA.

Objective: We evaluated the influence of the APOE-ε4 allele on post-concussive symptoms in military Veterans with a remote history of mild traumatic brain injury (mTBI).

Method: Participants (N = 77) were administered neuropsychiatric measures, on average, approximately 5 years following their most recent mTBI and provided a DNA sample for APOE genotyping. Veterans were divided into two groups based on their ε4 status (n = 14 ε4+, n = 63 ε4-). Read More

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Uveitis involves dysregulation of the ocular immune system. Stress has been shown to affect immune function, but it is unclear whether there is an association between stress and uveitis.

Objective: To determine whether having uveitis is associated with psychological stress. Read More

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.

Chem Commun (Camb) 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemistry, Duke University, Durham, North Carolina 27708, USA. and Department of Biochemistry, Duke University, Durham, North Carolina 27710, USA and Department of Physics, Duke University, Durham, North Carolina 27708, USA.

Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show that the sequence dependence of this selectivity results from competing charge transfer to the protein and through the DNA, with implications on the use of genome editing tools to influence the p53 regulatory function. Read More

G Ital Cardiol (Rome) 2018 Dec;19(12):692-704

Istituto di Cardiologia, Università degli Studi, Pisa.

Myocardial revascularization in patients with stable ischemic heart disease aims at eliminating myocardial ischemia, in order to (i) relieve anginal symptoms; (ii) improve functional capacity; and, possibly, (iii) improve prognosis. Given that ischemic recurrences are relatively common in patients undergoing myocardial revascularization, an appropriate follow-up is needed as part of a secondary prevention program. Stress testing can be here useful to: (i) detect residual or recurrent ischemia/angina; (ii) define functional capacity in order to establish physical aerobic training individualized programs; (iii) stratify prognosis. Read More

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

K.J. Kemper is founding director, Center for Integrative Health and Wellness and professor of pediatrics, The Ohio State University, Columbus, Ohio. H. McClafferty is director, Pediatric Integrative Medicine in Residency Program and co-director, the Fellowship in Integrative Medicine, The University of Arizona Center for Integrative Medicine, The University of Arizona College of Medicine, Tucson, Arizona. P.M. Wilson is assistant professor, Division of Emergency Medicine, Children's Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, Pennsylvania. J.R. Serwint is professor emeritus of pediatrics, Johns Hopkins University, Baltimore, Maryland. M. Batra is associate program director, Pediatric Residency Program and associate professor of pediatrics, Seattle Children's Hospital and the University of Washington in Seattle, Washington. J.D. Mahan is director, Pediatric Residency Program and professor of pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio. C.J. Schubert is professor of pediatrics, Cincinnati Children's Hospital Medical Center and The University of Cincinnati, Cincinnati, Ohio. B.B. Staples is director, Pediatric Residency Program and associate professor of pediatrics, Duke University Medical Center, Durham, North Carolina. A. Schwartz is Michael Reese Endowed Professor of Medical Education and director of research, University of Illinois College of Medicine, Chicago, Illinois, and data analyst, Association of Pediatric Program Directors Longitudinal Educational Assessment Research Network.

Purpose: Burnout symptoms are common among health professionals. Gaps remain in understanding both the stability of burnout and compassion over time and relationships among burnout, self-compassion, stress, and mindfulness in pediatric residents.

Method: The authors conducted a prospective cohort study of residents at 31 U. Read More

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound dysregulation of the DNA damage response, including upstream regulators and downstream p53 targets. Read More

J Clin Pediatr Dent 2018 Dec 6. Epub 2018 Dec 6.

Objective: Persistent primary teeth with healthy crown-root structures and acceptable functional and esthetic properties may be preserved over a long-term period if needed. However, they may experience root resorption, ankylosis or infraocclusion especially in the second or third decades of life. Despite a lack of sufficient detailed data, increases in occlusal forces by age are known to cause destructive stresses on root surfaces and periodontal tissue. Read More

Plant Dis 2018 Dec 6:PDIS05180734RE. Epub 2018 Dec 6.

State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Fruit bagging is a widely used orchard practice in China. Trichothecium black spot (TBS) is a disease highly associated with the fruit bagging. In this study, we characterized in vitro factors affecting the causal agent, Trichothecium roseum, and TBS development and infection histology on field-bagged apple fruit in situ. Read More