6,499 results match your criteria Streptococcus Group D Infections

Etiology and prevalence of ESBLs in adult community-onset urinary tract infections in East China: a prospective multicenter study.

J Infect 2021 Jun 8. Epub 2021 Jun 8.

Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, Zhejiang, China; Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Objectives: Community onset urinary tract infections (COUTIs) drew attention recently owing to their increased prevalence and associations with resistant pathogens. The study is aimed at investigating the etiology of COUTIs as well as prevalence and the related risk factors of extended-spectrum β-lactamase (ESBL) in COUTIs in China.

Methods: The prospective study was performed in nineteen hospitals during November 1, 2017 and August 31, 2019. Read More

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Comparative analysis of bacterial content, levels of lipopolysaccharides and lipoteichoic acid in symptomatic and asymptomatic endodontic infections at different stages of endodontic treatment.

Clin Oral Investig 2021 Jun 11. Epub 2021 Jun 11.

Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School - State University of Campinas, UNICAMP, Av Limeira 901, Piracicaba, São Paulo, Brazil.

Objectives: This study aimed to detect the presence of specific bacteria and to evaluate the levels of lipopolysaccharides (LPS) and lipoteichoic acid (LTA) in symptomatic necrotic root canals associated with acute apical abscess (symptomatic group - GI). It also aimed to compare the findings with those presented by asymptomatic necrotic root canals (asymptomatic group - GII) in the different stages of the endodontic treatment.

Materials And Methods: Microbiological samples were collected from 20 root canals, including purulent collection from acute apical abscesses, before and after chemo-mechanical preparation (CMP) preparation (CMP) with chlorhexidine gel 2% and after 30 days of intracanal medication (ICM) with (Ca[OH]) + chlorhexidine. Read More

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Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal.

Front Med (Lausanne) 2021 24;8:641646. Epub 2021 May 24.

Departamento de Química Inorgánica y Orgánica, Universitat Jaume I, Castellón, Spain.

New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has prepared and described two new readily available materials based on the combination of Rose Bengal (singlet oxygen photosensitizer) and commercially available cationic polystyrene (macroporous resin Amberlite® IRA 900 or gel-type resin IRA 400). These materials showed high efficacy in the antimicrobial photodynamic inactivation (aPDI) of . Read More

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Causative Agents of Urinary Tract Infections in Elderly Men with Benign Prostatic Hyperplasia: a Microbiological Evaluation.

Clin Lab 2021 Jun;67(6)

Background: Benign prostatic hyperplasia is an important risk factor for urinary tract infections. In this study, the causative agents of urinary tract infections were isolated from urine samples of benign prostatic hyperplasia patients aged 65 and older. Bacteremia risk and the patterns of antibiotic resistance were investigated to guide clinicians in empirical antibiotic treatment. Read More

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Raoultella ornithinolytica urinary tract infection in a pediatric patient with T-cell precursor acute lymphoblastic leukemia.

Bol Med Hosp Infant Mex 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA; Comité de Medicina Tropical, Zoonosis y Medicina del Viajero, Asociación Colombiana de Infectología, Bogotá, Colombia.

Background: Currently, Raoultella ornithinolytica is considered an emerging pathogen of community- and hospital-acquired infection, particularly in patients with immunodeficiencies, malignancies, anatomical abnormalities, or after invasive procedures. Pediatric infections with R. ornithinolytica are exceedingly rare, with only six previously reported cases, of which only two were reported as a urinary tract infection. Read More

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Influence of Luseogliflozin on Vaginal Bacterial and Fungal Populations in Japanese Patients With Type 2 Diabetes.

J Clin Med Res 2021 May 25;13(5):309-316. Epub 2021 May 25.

Office of Medical Education, School of Medicine, International University of Health and Welfare, 4-3, Kozunomori, Narita-shi, Chiba 286-8686, Japan.

Background: Selective sodium-glucose cotransporter 2 inhibitors, known to lower the blood glucose levels by promoting the urinary glucose excretion, can predispose to genitourinary infections. This prospective study investigated the influence of selective sodium-glucose cotransporter 2 inhibitors luseogliflozin on the vaginal flora of the pre- and postmenopausal women with type 2 diabetes mellitus.

Methods: Twelve premenopausal and 24 postmenopausal female Japanese patients with type 2 diabetes mellitus took luseogliflozin 2. Read More

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Readily Adapts Membrane Phospholipid Composition to Environmental and Genetic Perturbation.

Front Microbiol 2021 21;12:616045. Epub 2021 May 21.

Department of Microbiology, University of Tennessee, Knoxville, Knoxville, TN, United States.

The bacterial lipid membrane, consisting both of fatty acid (acyl) tails and polar head groups, responds to changing conditions through alteration of either the acyl tails and/or head groups. This plasticity is critical for cell survival as it allows maintenance of both the protective nature of the membrane as well as functioning membrane protein complexes. Bacteria that live in fatty-acid rich environments, such as those found in the human host, can exploit host fatty acids to synthesize their own membranes, in turn, altering their physiology. Read More

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Pediatric sepsis cases diagnosed with group B streptococcal meningitis using next-generation sequencing: a report of two cases.

BMC Infect Dis 2021 Jun 5;21(1):531. Epub 2021 Jun 5.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Group B Streptococcus (GBS) is an important cause of invasive infection in neonates and infants. Cerebrospinal fluid (CSF) findings and culture may not show evidence of infection early in GBS meningitis. Next-generation sequencing (NGS) has the potential to detect microbial genetic material in patients with infectious diseases. Read More

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Antibiofilm activity of laser ablation with indocyanine green activated photodynamic therapy on root canals infected with Enterococcus faecalis.

Photodiagnosis Photodyn Ther 2021 Jun 1:102377. Epub 2021 Jun 1.

Department of Preventive and Restorative Dentistry, São Paulo State University (UNESP) School of Dentistry, Araçatuba, SP, Brazil. Electronic address:

Background: Antimicrobial Photodynamic therapy (aPDT) is used as an adjunct to endodontic treatment to enhance the microbial reduction in the root canal system. However, studies evaluating the impact of Laser Ablation with Indocyanine Green (ICG) are scarce. Thus, this in vitro study aimed to evaluate the efficiency of Laser Ablation with ICG using different laser parameters compared with aPDT using photosensitizer methylene blue (MB) and curcumin (CUR) on the reduction of E. Read More

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Induction of proteome changes involved in biofilm formation of Enterococcus faecalis in response to gentamicin.

Microb Pathog 2021 Jun 1;157:105003. Epub 2021 Jun 1.

Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Enterococcus faecalis is a significant cause of nosocomial infections and other diseases, including endocarditis, bacteremia, and urinary tract infections. This microorganism forms biofilms to overcome difficult environmental conditions, such as lack of oxygen, lack of water, and the presence of antimicrobials. These biofilms make diseases difficult by changing their proteome contents, protecting the bacterium, and increasing their pathogenicity. Read More

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TCF-ALP: a fluorescent probe for the selective detection of bacteria and application in "smart" wound dressings.

Biomater Sci 2021 Jun 2. Epub 2021 Jun 2.

Department of Chemistry, University of Bath, BA2 7AY, UK.

Alkaline phosphatase (ALP) is an important enzyme-based biomarker present in several bacterial species; however, it is currently undervalued as a strategy to detect pathogenic bacteria. Here, we explore our ALP-responsive colorimetric and fluorescent probe (TCF-ALP) for such applications. TCF-ALP displayed a colorimetric and fluorescence response towards Staphylococcus aureus (S. Read More

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Urinary tract infection caused by Enterococcus spp.: Risk factors and mortality. An observational study.

Rev Clin Esp (Barc) 2021 May 29. Epub 2021 May 29.

Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla (HUMV), Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain.

Background And Objective: Urinary tract infections (UTIs) are frequently caused by Enterococcus spp. This work aims to define the risk factors associated with UTIs caused by Enterococci and to determine its overall mortality and predictive risk factors.

Materials And Methods: A retrospective study was conducted on bacteremic UTIs caused by Enterococcus spp. Read More

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Peptide/β-Peptoid Hybrids with Activity against Vancomycin-Resistant Enterococci: Influence of Hydrophobicity and Structural Features on Antibacterial and Hemolytic Properties.

Int J Mol Sci 2021 May 25;22(11). Epub 2021 May 25.

Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Infections with enterococci are challenging to treat due to intrinsic resistance to several antibiotics. Especially vancomycin-resistant and are of considerable concern with a limited number of efficacious therapeutics available. From an initial screening of 20 peptidomimetics, 11 stable peptide/β-peptoid hybrids were found to have antibacterial activity against eight and isolates. Read More

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Antimicrobial Photodynamic Inactivation Affects the Antibiotic Susceptibility of spp. Clinical Isolates in Biofilm and Planktonic Cultures.

Biomolecules 2021 May 5;11(5). Epub 2021 May 5.

Laboratory of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, 80-307 Gdansk, Poland.

and are opportunistic pathogens that can cause a vast variety of nosocomial infections. Moreover, belongs to the group of ESKAPE microbes, which are the main cause of hospital-acquired infections and are especially difficult to treat because of their resistance to many antibiotics. Antimicrobial photodynamic inactivation (aPDI) represents an alternative to overcome multidrug resistance problems. Read More

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Clinical characteristics and prediction analysis of pediatric urinary tract infections caused by gram-positive bacteria.

Sci Rep 2021 May 26;11(1):11010. Epub 2021 May 26.

Big Data Center, China Medical University Hospital, No. 2 Yuder Rd., North Dist., Taichung , 404, Taiwan, ROC.

Gram-positive (GP) pathogens are less accounted for in pediatric urinary tract infection (UTI), and their clinical impact is underrecognized. This study aimed to identify predictors of GP uropathogens in pediatric UTI. In this 14-year retrospective cohort of pediatric patients with UTI, we classified first-time UTIs cases into those caused by GP or Gram-negative (GN) bacteria. Read More

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Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units.

Drugs 2021 May 26. Epub 2021 May 26.

UFR Denis Diderot, INSERM UMR 1152, ANR-10-LABX-17, Department of Anaesthesiology and Critical Care Medicine, DMU PARABOL, CHU Bichat-Claude Bernard, AP-HP, Université de Paris, Paris, France.

Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. Read More

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Trend of Bacterial Uropathogens and Their Susceptibility Pattern: Study of Single Academic High-Volume Center in Italy (2015-2019).

Int J Microbiol 2021 21;2021:5541706. Epub 2021 Apr 21.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi 84081, SA, Italy.

Urinary tract infections (UTIs) are a very widespread infection that can occur in disparate age range, in both sexes and in pregnancy/menopause state. Treatment of UTIs is difficult due to the emergence of antibiotic-resistant bacterial strains. The present study shows five years of data collected on patients admitted at the University Hospital "San Giovann di Dio e Ruggi d'Aragona" in Salerno, Italy. Read More

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Antimicrobial and immunomodulatory in vitro profile of double antibiotic paste.

Int Endod J 2021 May 25. Epub 2021 May 25.

Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil.

Aim: To evaluate the antimicrobial and immunomodulatory activity of double antibiotic paste (DAP) in an in vitro infection model.

Methodology: The minimum inhibitory and bactericidal concentrations (MIC and MBC) and the anti-biofilm activities (TTC assay) of DAP and its components (ciprofloxacin and metronidazole) were evaluated against Staphylococcus aureus and Enterococcus faecalis compared to triple antibiotic paste (TAP). The cellular viability of RAW 264. Read More

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Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy.

Bioact Mater 2021 Aug 5;6(8):2629-2642. Epub 2021 Jan 5.

Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere, 100 - 00133, Rome, Italy.

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone, thus significantly increasing implants failure rate. To address infection and promote integration, here nanostructured antibacterial and bioactive thin films are proposed, obtained, for the first time, by Ionized Jet Deposition (IJD) of silver-substituted tricalcium phosphate (Ag-TCP) targets on titanium. Coatings morphology, composition and mechanical properties are characterized and proof-of-concept of biocompatibility is shown. Read More

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Drug Repurposing: and Antimicrobial and Antibiofilm Effects of Bithionol Against and .

Front Microbiol 2021 6;12:579806. Epub 2021 May 6.

Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha, China.

Widespread antibiotic resistance has been reported in enterococcal pathogens that cause life-threatening infections. Enterococci species rapidly acquire resistance and the pace of new antibiotic development is slow. Drug repurposing is a promising approach in solving this problem. Read More

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The microbiological profile of patients with Fournier's gangrene: A retrospective multi-institutional cohort study.

Urologia 2021 May 22:3915603211018441. Epub 2021 May 22.

Urology Unit, San Carlo di Nancy Hospital - GVM Care and Research, Rome, Italy.

Objectives: To evaluate the role of the microbiological profile and of disease-related factors in the management of patients affected with Fournier's gangrene (FG).

Patients And Methods: Data regarding patients admitted for FG at nine Italian Hospitals (March 2007-June 2018) were collected. Patients were stratified according to the number of microorganisms documented: Group A - one microorganism; Group B - two microorganisms; Group C - more than three microorganisms. Read More

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Synthesis, characterization and utility of a series of novel copper(II) complexes as excellent surface disinfectants against nosocomial infections.

Dalton Trans 2021 May 20. Epub 2021 May 20.

Laboratory of Infection Biology and Translational Research, Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.

Nosocomial infections are among the major public health concerns, especially during the ongoing Covid19 pandemic. There is a great demand for novel chemical agents that are capable of killing specific pathogens or augmenting the efficiency of existing disinfectants. Herein, we report the synthesis and comprehensive characterization (through FT-IR, HR-MS, SEM, TGA-DSC, CV, UV and SCXRD analyses) of six novel copper(ii) complexes, [CuL(4X-An)] (5a-5d), [CuL(An)] (5e), and [CuL(benzhydrylamine)] (5f), and their evaluation as anti-microbial agents against WHO priority pathogens, confirming their possible use in hospital settings. Read More

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The risk factors and care measures of surgical site infection after cesarean section in China: a retrospective analysis.

BMC Surg 2021 May 19;21(1):248. Epub 2021 May 19.

Department of Obstetrics, Tianjin Central Hospital of Gynecology Obstetrics, No. 156 Nankai three Road, Nankai District, Tianjin, China.

Background: Surgical site infections after cesarean section are very common clinically, it is necessary to evaluate the risk factors of surgical site infections after cesarean section, to provide evidences for the treatment and nursing care of cesarean section.

Methods: This study was a retrospective cohort study design. Patients undergone cesarean section in a tertiary hospital of China from May 2017 to May 2020 were identified, we collected the clinical data of the included patients, and we analyzed the infection rate, etiological characteristics and related risk factors of surgical site infection after caesarean section. Read More

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Phenotype-Genotype Correlations and Distribution of Key Virulence Factors in Isolated from Patients with Urinary Tract Infections.

Infect Drug Resist 2021 10;14:1713-1723. Epub 2021 May 10.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background And Objective: can cause different nosocomial infections, especially urinary tract infection (UTI). Pathogenicity of is driven by various virulence factors; however, no specific genetic pattern is restricted to a particular type of infection. The current study aimed to investigate the correlation between different virulence factors in clinical isolates causing UTIs. Read More

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Influence of the Alternative Sigma Factor RpoN on Global Gene Expression and Carbon Catabolism in Enterococcus faecalis V583.

mBio 2021 May 18;12(3). Epub 2021 May 18.

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA

The alternative sigma factor σ has been shown to regulate the expression of a wide array of virulence-associated genes, as well as central metabolism, in bacterial pathogens. In Gram-positive organisms, the σ is commonly associated with carbon metabolism. In this study, we show that the alternative sigma factor σ (RpoN) and its cognate enhancer binding protein MptR are essential for mannose utilization and are primary contributors to glucose uptake through the Mpt phosphotransferase system. Read More

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Diversity of metal and antibiotic resistance genes in Enterococcus spp. from the last century reflects multiple pollution and genetic exchange among phyla from overlapping ecosystems.

Sci Total Environ 2021 Sep 14;787:147548. Epub 2021 May 14.

UCIBIO/REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Portugal. Electronic address:

Arsenic (As), mercury (Hg), and copper (Cu) are among the major historical and contemporary metal pollutants linked to global anthropogenic activities. Enterococcus have been considered indicators of fecal pollution and antibiotic resistance for years, but its largely underexplored metallome precludes understanding their role as metal pollution bioindicators as well. Our goal was to determine the occurrence, diversity, and phenotypes associated with known acquired genes/operons conferring tolerance to As, Hg or Cu among Enterococcus and to identify their genetic context (381 field isolates from diverse epidemiological and genetic backgrounds; 3547 enterococcal genomes available in databases representing a time span during 1900-2019). Read More

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September 2021

Development and Characterization of High-Throughput - Infection Model.

Front Cell Infect Microbiol 2021 29;11:667327. Epub 2021 Apr 29.

Department of BioSciences, Rice University, Houston, TX, United States.

The genus includes two Gram-positive pathogens of particular clinical relevance: and . Infections with each of these pathogens are becoming more frequent, particularly in the case of hospital-acquired infections. Like most other bacterial species of clinical importance, antimicrobial resistance (and, specifically, multi-drug resistance) is an increasing threat, with both species considered to be of particular importance by the World Health Organization and the US Centers for Disease Control. Read More

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Competence Mining of Vancomycin (VAN) in the Management of Infections Due to Bacterial Strains With High VAN Minimum Inhibitory Concentrations (MICs): A Novel Dosing Strategy Based on Pharmacokinetic/Pharmacodynamic Modeling.

Front Microbiol 2021 22;12:649757. Epub 2021 Apr 22.

Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

The increasing emergence of bacterial strains with high VAN MICs (BS ), such as , , , , and , results in growing concern that VAN is not effective against these isolates. Due to the limited data on VAN against BS and the application limits of drugs currently considered to be effective for BS , exploration of "new usages for old drugs" is reasonable to improve and maximize the efficacy of existing antibiotics. This study aimed to construct a novel dosing strategy to mine the competence of VAN in the management of BS infections. Read More

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Study of the ultrastructure of Enterococcus faecalis and Streptococcus mutans incubated with salivary antimicrobial peptides.

Clin Exp Dent Res 2021 May 5. Epub 2021 May 5.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Col. Universidad Nacional Autónoma de México, Mexico City, Mexico.

Objectives: Enterococcus faecalis has been associated with root canal infections, while Streptococcus mutans has a central role in the etiology of dental caries. One of the main reasons of endodontic failure has been associated to the presence of E. faecalis and the formation of biofilms. Read More

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Pathogen distribution and risk factors for urinary tract infection in infants and young children with retained double-J catheters.

J Int Med Res 2021 May;49(5):3000605211012379

Affiliated Foshan Maternal and Child Healthcare Hospital, Southern Medical University, Foshan, China.

Objectives: To investigate the pathogens and potential risk factors for urinary tract infection (UTI) in patients with retained double-J catheters (DJCs).

Methods: In total, 107 infants and young children with DJCs were included in this retrospective analysis. Patients were included in the infection group (n = 30) or non-infection group (n = 77), according to UTI presence or absence. Read More

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