102,979 results match your criteria Streptococcus Group D Infections


Dirhodium (II) complex interferes with iron-transport system to exert antibacterial action against Streptococcus pneumoniae.

J Proteomics 2018 Dec 3. Epub 2018 Dec 3.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address:

Drug resistance in bacteria is becoming a significant threat to global public health, and the development of novel and efficient antibacterial compounds is urgently needed. Recently, rhodium complexes have attracted attention as antimicrobial agents, yet their antibacterial mechanism remains unknown. In this study, we observed that the dirhodium (II) complex RhAc inhibited Streptococcus. Read More

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December 2018
1 Read

Strangles, convalescent Streptococcus equi subspecies equi M antibody titers, and presence of complications.

J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.

Equine Diagnostic Solutions LLC, Lexington, Kentucky.

Background: Streptococcus equi subspecies equi infection elicits M protein antibody titers in equids. Interpretation of titers is not generally accepted.

Hypothesis: The magnitude of S. Read More

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December 2018
1 Read

Antagonism of Bacteria from Dog Dental Plaque against Human Cariogenic Bacteria.

Biomed Res Int 2018 4;2018:2780948. Epub 2018 Nov 4.

Laboratory of Microbiology Studies, Life Sciences Institute, Campus Governador Valadares, Federal University of Juiz de Fora, Rua São Paulo 745, Centro, Governador Valadares, MG, 35010180, Brazil.

Dental caries are a process of demineralization and destruction of human teeth. They originate through many factors and are associated with biofilm formation, which consists of bacteria adhered to the teeth that form a structurally and functionally organized mass called dental plaque. Both the presence of and the frequent consumption of sucrose correlate with a higher prevalence of caries in humans. Read More

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November 2018
2 Reads

Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population.

Gut Pathog 2018 29;10:49. Epub 2018 Nov 29.

7Physics Department, Boston University, Boston, USA.

Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population. Read More

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November 2018
1 Read

Assessment of Test Performance and Potential for Environmental Contamination Associated with a Point-of-Care Molecular Assay for Group A in an End-User Setting.

J Clin Microbiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.

Although FDA-approved and CLIA-waived point-of-care (POC) molecular systems are being implemented in routine clinical practice, instrument reliability, test performance in the hands of end-users, and the potential for environmental contamination resulting from use of POC molecular systems have not been extensively evaluated. We performed a prospective evaluation of the Roche cobas Liat group A streptococcus (GAS) assay compared to routine real-time PCR. We evaluated test accuracy, instrument failure rate, and monitored for environmental contamination when testing was performed by minimally trained end users in an Express Care Clinic environment. Read More

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December 2018

NmeCas9 is an intrinsically high-fidelity genome-editing platform.

Genome Biol 2018 Dec 5;19(1):214. Epub 2018 Dec 5.

RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.

Background: The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wildtype SpyCas9 can induce significant levels of unintended mutations at near-cognate sites, necessitating substantial efforts toward the development of strategies to minimize off-target activity. Read More

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December 2018

Epidemiology of lower respiratory tract infections in adults.

Expert Rev Respir Med 2018 Dec 6. Epub 2018 Dec 6.

b Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa .

Introduction: Lower respiratory tract infections (LRTIs) are the leading infectious disease cause of death in the world and the fifth overall cause of death. From an epidemiological point of view, most consider pneumonia, influenza, bronchitis (including acute exacerbations in chronic obstructive pulmonary disease [AECOPD]), and bronchiolitis to be the most important LRTIs. Areas covered: This review will describe the epidemiology of LRTIs in adults focusing on community-acquired pneumonia, influenza, and AECOPD, utilizing data from the more recent literature. Read More

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December 2018
3 Reads

Érysipèle.

Rev Prat 2016 Nov;67(9):991-996

Service de médecine interne et polyvalente, centre hospitalier de Polynésie française, Pirae, Polynésie française.

Erysipelas. Erysipelas is a non-necrotizing acute dermohypodermitis of streptococcal origin (group A beta-hemolytic streptococcus) that usually affects adults and tends to reoccur. Risk factors recognized by the 2000 Consensus Conference are lymphedema, the existence of a gateway and obesity. Read More

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November 2016

Identification of novel immunogenic proteins against Streptococcus parauberis in a zebrafish model by reverse vaccinology.

Microb Pathog 2018 Nov 30. Epub 2018 Nov 30.

Biotechnology Process Engineering Center, KRIBB, Cheongju, 363-883, Republic of Korea; Department of Biotechnology Process Engineering, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 305-350, Republic of Korea. Electronic address:

Streptococcus parauberis is the major infectious agent of streptococcosis in the olive flounder (Paralichthys olivaceus), causing serious economic damage. In this study, we identified potential vaccine candidates against S. parauberis by reverse vaccinology. Read More

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November 2018

Fatal Streptoccocus canis Necrotizing Fasciitis and Myositis in a Free-Ranging Iberian Lynx ( Lynx pardinus).

J Wildl Dis 2018 Dec 3. Epub 2018 Dec 3.

7 Dirección General de Medio Ambiente, Junta de Extremadura, Avda. de Luis Ramallo s/n, 06800 Mérida (Badajoz), Spain.

A free-ranging Iberian lynx ( Lynx pardinus) was found dead after 16 mo of being reintroduced. On gross necropsy, necrotic areas in the left biceps femoris and intercostal muscles were identified. Streptococcus canis was isolated from both groups of muscles and was confirmed by PCR, corroborating a necrotizing myositis diagnostic. Read More

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December 2018

Risk factors and drug resistance in early-onset neonatal group B streptococcal disease.

J Zhejiang Univ Sci B 2018 Dec.;19(12):973-978

Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

In recent years, group B streptococcus (GBS) has become an important pathogen that causes infections in many neonatal organs, including the brain, lung, and eye (Ballard et al., 2016). A series of studies performed on GBS infections in western countries have revealed that GBS is one of the primary pathogens implicated in perinatal infection, and GBS infections are a major cause of neonatal morbidity and mortality in the United States (Decheva et al. Read More

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December 2018

Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas Gingivalis.

J Periodontol 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387, Kraków, Poland.

Background: Statins effectively reduce risk of cardiovascular-related morbidity and mortality in patients with hyperlipidemia, hypertension or type-II diabetes. In addition to lowering cholesterol levels, several studies have attributed statins with immunomodulatory and bactericidal properties. Therefore, the aim of this study was to investigate statins' antimicrobial activity against relevant for periodontal homeostasis bacteria. Read More

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December 2018

Paediatric community-acquired bacteraemia, pneumococcal invasive disease and antibiotic resistance fell after the pneumococcal conjugate vaccine was introduced.

Acta Paediatr 2018 Dec 2. Epub 2018 Dec 2.

Pediatric Infectious Disease Unit of Dana Children's Hospital, Tel Aviv Sourasky Medical Centre, Tel Aviv, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Aim: This study examined the impact of the routine pneumococcal conjugate vaccination (PCV) on childhood community-acquired bacteraemia (CAB) and antibiotic resistance patterns in Israeli children.

Methods: Israel added the PCV vaccine to its national immunisation programme in July 2009. We retrospectively analysed the medical records of all patients with CAB under 18 years at three children's hospitals in Tel Aviv and Jerusalem from 2007-2015. Read More

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December 2018

Yogurt Production.

Authors:
Seiji Nagaoka

Methods Mol Biol 2019 ;1887:45-54

Fermented Milk Development Department, Food Development Laboratories, R&D Division, Meiji Co., Ltd., Hachiouji, Tokyo, Japan.

Yogurt is a popular fermented dairy product produced by lactic acid bacteria, including Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus. During yogurt production, these bacteria produce lactic acid, decreasing pH and causing milk protein to coagulate. Read More

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January 2019

Qualitative and Quantitative DNA- and RNA-Based Analysis of the Bacterial Stomach Microbiota in Humans, Mice, and Gerbils.

mSystems 2018 Nov-Dec;3(6). Epub 2018 Nov 20.

Universität Hohenheim, Stuttgart, Germany.

Clinical interventions in the stomach have been linked to fecal microbiota alterations, suggesting a function of the stomach in gastrointestinal (GI) homeostasis. We sought to determine the taxonomic bacterial biogeography of the upper GI tract, including different sites within the human stomach (cardia, corpus, and antrum), adjacent upstream (esophagus) and downstream (duodenum) locations, and luminal contents (aspirate), as well as whole-stomach samples from mice and gerbils. Qualitative and quantitative DNA- and RNA-based taxonomic microbiota analyses were combined to study the relationship of relative and absolute bacterial abundances and transcriptionally active bacterial microbiota components in the stomach of humans and mice. Read More

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November 2018

Epidemiological characterization of serotype group B Streptococci neonatal infections associated with interleukin-6 level as a sensitive parameter for the early diagnosis.

Saudi J Biol Sci 2018 Nov 7;25(7):1356-1364. Epub 2015 Nov 7.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.

Group B streptococcal infection () is one of the leading causes of life-threatening disease in the early neonatal period, resulting in sepsis, pneumonia, and meningitis. During invasive infections, an excessive release of pro-inflammatory cytokine, such as interleukin-6 (IL-6), thus IL-6 gene is significant, as a diagnostic marker of systemic infection of the newborns. The present study aimed to describe the epidemiology diagnostic of GBS disease in neonatal by phenotypic and genotypic methods. Read More

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November 2018

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

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December 2018

Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning.

Sci Rep 2018 Nov 30;8(1):17517. Epub 2018 Nov 30.

University of Nottingham School of Veterinary Medicine and Science, College Road, Sutton Bonington, Leicestershire, LE12 5RD, UK.

Streptococcus uberis is one of the most common pathogens of clinical mastitis in the dairy industry. Knowledge of pathogen transmission route is essential for the selection of the most suitable intervention. Here we show that spectral profiles acquired from clinical isolates using matrix-assisted laser desorption ionization/time of flight (MALDI-TOF) can be used to implement diagnostic classifiers based on machine learning for the successful discrimination of environmental and contagious S. Read More

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November 2018

Snow and Reindeer: Large Tricuspid Valve Mobile Vegetation.

J Invasive Cardiol 2018 Dec;30(12):E155

Staten Island University Hospital-Northwell Health, 475 Seaview Avenue, Staten Island, NY 10305 USA.

A 20-year-old female with history of polysubstance abuse presented with fevers and lightheadness. Blood cultures grew out Streptococcus constellatus, which is known to form purulent infections when introduced in the body. Evaluation with transesophageal echocardiogram showed a definite large, irregular, loosely organized, highly mobile vegetation. Read More

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December 2018

Effects of Panax ginseng polysaccharides on the gut microbiota in mice with antibiotic-associated diarrhea.

Int J Biol Macromol 2018 Nov 30. Epub 2018 Nov 30.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, PR China; College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, PR China. Electronic address:

Panax ginseng is a traditional medicinal plant used in most Asian countries to cure many diseases. The benefits of ginseng are due to its primary active component, polysaccharides. Gut microbiota dysbiosis is a worldwide problem associating with antibiotic use. Read More

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November 2018

Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells.

Auris Nasus Larynx 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Objective: Phosphorylcholine (PC) is a structural component of Streptococcus pneumoniae (Spn) and nontypeable Haemophilus influenzae (NTHi), and is known to be associated with adherence through the platelet activating factor receptor (PAF-R). Furthermore, high PC expression is considered to be involved in Spn and NTHi virulence. In this study, we examined the influence of PC expression on the adherence of Spn and NTHi to epithelial cells in order to clarify the potential effectiveness of a vaccine targeting PC. Read More

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November 2018

Antibacterial effects of polymeric PolymP-n Active nanoparticles. An in vitro biofilm study.

Dent Mater 2018 Nov 29. Epub 2018 Nov 29.

ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.

Objective: to study the antibacterial effect of polymeric PolymP-n Active nanoparticles using an in vitro subgingival biofilm model.

Methods: Hydroxyapatite discs coated with five modalities of nanoparticles (NPs): NPs, NPs doped with zinc, calcium, silver and doxycycline, PBS as control, and Streptococcus oralis, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans were studied in a static in vitro biofilm model (12, 24, 48, and 72h). Nano-roughness of the different disc surfaces (SRa, in nm) and morphological characteristic of the biofilms (thickness (μm) and bacterial viability) were studied by different microscopy modalities. Read More

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November 2018

Physical properties and cytotoxicity of antimicrobial dental resin adhesives containing dimethacrylate oligomers of Ciprofloxacin and Metronidazole.

Dent Mater 2018 Nov 29. Epub 2018 Nov 29.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario, Canada; Faculty of Dentistry, University of Toronto, Ontario, Canada. Electronic address:

Objective: Antimicrobial oligomers synthesized from ciprofloxacin (CF) and metronidazole (MN) were investigated for their potential use in dental adhesives.

Methods: Susceptibility of the cariogenic bacterium Streptococcus mutans UA159 to CF, MN, and CF/MN combination was evaluated. Hydrolytic stability and drug release from the oligomers was studied in buffer and simulated human salivary esterase conditions. Read More

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November 2018
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Long-term pneumococcal vaccine immunogenicity following allogeneic hematopoietic stem cell transplantation.

Vaccine 2018 Nov 27. Epub 2018 Nov 27.

Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, the Netherlands. Electronic address:

Infection with Streptococcus pneumoniae is a life-threatening, but vaccine preventable complication in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). The international consensus on post allo-HSCT immunization schedules, starting 3-6 months after HSCT, focuses on short-term immunogenicity while long-term immunogenicity is not well characterized. The current Dutch immunization schedule, which starts at 12 months post allo-HSCT, was developed as a result of concerns on the coverage of long-term immunogenicity in international guidelines. Read More

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November 2018

Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia.

BMC Pediatr 2018 Nov 30;18(1):378. Epub 2018 Nov 30.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.

Background: Group B Streptococcus (GBS) that asymptomatically colonizing the recto-vaginal area of women is the most important cause of neonatal colonization. There is paucity of evidence about newborn colonization with GBS in Ethiopia. Thus, this study was aimed to determine the prevalence of newborn colonization with GBS, antibiotic susceptibility patterns of the isolates and associated risk factors at the University of Gondar Referral Hospital in Northwest Ethiopia METHODS: A prospective cross sectional study was conducted from December 2016 to November 2017. Read More

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November 2018

[A multicenter clinical study on 1 138 cases of invasive pneumococcal disease in children from 2012 to 2017].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):915-922

Zunyi Medical University, Zunyi 563003, China.

To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD). By retrieving the laboratory information system in 18 children's hospitals from 2012 to 2017, the children with IPD were enrolled. (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc. Read More

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December 2018
4 Reads

Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity.

Nucleic Acids Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Chemistry & Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, USA.

CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofactors to guide catalysis. Read More

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December 2018

2018 recommendations for the management of community acquired pneumonia.

J Bras Pneumol 2018 Sep-Oct;44(5):405-423

. Faculdade de Medicina, Universidade Estadual de Campinas - Unicamp - Campinas (SP) Brasil.

Community-acquired pneumonia (CAP) is the leading cause of death worldwide. Despite the vast diversity of respiratory microbiota, Streptococcus pneumoniae remains the most prevalent pathogen among etiologic agents. Despite the significant decrease in the mortality rates for lower respiratory tract infections in recent decades, CAP ranks third as a cause of death in Brazil. Read More

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April 2018
1 Read

The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.

PLoS Pathog 2018 Dec 5;14(12):e1007461. Epub 2018 Dec 5.

Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America.

Efficient and highly organized regulation of transcription is fundamental to an organism's ability to survive, proliferate, and quickly respond to its environment. Therefore, precise mapping of transcriptional units and understanding their regulation is crucial to determining how pathogenic bacteria cause disease and how they may be inhibited. In this study, we map the transcriptional landscape of the bacterial pathogen Streptococcus pneumoniae TIGR4 by applying a combination of high-throughput RNA-sequencing techniques. Read More

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December 2018

Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.

PLoS One 2018 5;13(12):e0207897. Epub 2018 Dec 5.

Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Inactivating mutations in the control of virulence two-component regulatory system (covRS) often account for the hypervirulent phenotype in severe, invasive group A streptococcal (GAS) infections. As CovR represses production of the anti-phagocytic hyaluronic acid capsule, high level capsule production is generally considered critical to the hypervirulent phenotype induced by CovRS inactivation. There have recently been large outbreaks of GAS strains lacking capsule, but there are currently no data on the virulence of covRS-mutated, acapsular strains in vivo. Read More

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December 2018
3 Reads

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5752-5761

University of Houston College of Optometry, Houston, Texas, United States.

Purpose: The purpose of this study was to explore differences in genotype, ocular surface microbiome, tear inflammatory markers, and environmental and behavioral exposures in soft contact lens (SCL) wearers with and without a history of corneal infiltrative events (CIEs).

Methods: Nine SCL wearers with a recent CIE and nine age-, sex-, and SCL material- and modality-matched controls were enrolled. The Contact Lens Risk Survey, slit-lamp examination data, basal tears, conjunctival microbial cultures, and peripheral blood samples were collected. Read More

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December 2018
3 Reads

Routine Diagnostic Tests for Periprosthetic Joint Infection Demonstrate a High False-Negative Rate and Are Influenced by the Infecting Organism.

J Bone Joint Surg Am 2018 Dec;100(23):2057-2065

The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Current guidelines recommend serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first-line testing for evaluation of suspected periprosthetic joint infection, in addition to synovial white blood-cell (WBC) count and polymorphonuclear percentage. However, the sensitivity and other diagnostic measures of these tests using a standardized definition of periprosthetic joint infection and the influence of organisms on these inflammatory markers remain inadequately investigated.

Methods: A retrospective review of an institutional database of 549 periprosthetic joint infection cases and 653 aseptic total joint arthroplasty revisions was performed. Read More

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December 2018
1 Read

The Relationship between Colonization by and Tonsillar Hypertrophy.

Can J Infect Dis Med Microbiol 2018 1;2018:5406467. Epub 2018 Nov 1.

Department of Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, SP 14049-900, Brazil.

We sought to investigate the prevalence of potentially pathogenic bacteria in secretions and tonsillar tissues of children with chronic adenotonsillitis hypertrophy compared to controls. Prospective case-control study comparing patients between 2 and 12 years old who underwent adenotonsillectomy due to chronic adenotonsillar hypertrophy to children without disease. We compared detection of , , , and by real-time PCR in palatine tonsils, adenoids, and nasopharyngeal washes obtained from 37 children with and 14 without adenotonsillar hypertrophy. Read More

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November 2018
1 Read

Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.

Front Immunol 2018 20;9:2675. Epub 2018 Nov 20.

Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Epalinges, Switzerland.

Sirtuin 5 (SIRT5) is a member of the family of NAD-dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine to regulate metabolic and oxidative stress response pathways. Pharmacologic inhibitors of SIRT5 are under development for oncologic conditions, but nothing is known about the impact of SIRT5 on antimicrobial innate immune defenses. Read More

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November 2018
2 Reads

Protection Against Invasive Infections in Children Caused by Encapsulated Bacteria.

Front Immunol 2018 20;9:2674. Epub 2018 Nov 20.

Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

The encapsulated bacteria , and (Group B Streptococcus) have been responsible for the majority of severe infections in children for decades, specifically bacteremia and meningitis. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines. Protection against these bacteria is largely mediated via polysaccharide-specific antibody and complement, although the contribution of these and other components, and the precise mechanisms, vary between species and include opsonophagocytosis and complement-dependent bacteriolysis. Read More

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November 2018
1 Read

Investigation of the Role That NADH Peroxidase Plays in Oxidative Stress Survival in Group B .

Front Microbiol 2018 20;9:2786. Epub 2018 Nov 20.

Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United States.

Macrophages play an important role in defending the host against infections by engulfing pathogens and containing them inside the phagosome, which consists of a harsh microbicidal environment. However, many pathogens have developed mechanisms to survive inside macrophages despite this challenge. Group B (GBS), a leading cause of sepsis and meningitis in neonates, is one such pathogen that survives inside macrophages by withstanding phagosomal stress. Read More

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November 2018

Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery.

J Biol Chem 2018 Dec 4. Epub 2018 Dec 4.

Infectious Disease, University of California, San Francisco, United States.

The serine-rich repeat (SRR) glycoproteins of Gram-positive bacteria are large, cell wall-anchored adhesins that mediate binding to many host cells and proteins and are associated with bacterial virulence. SRR glycoproteins are exported to the cell surface by the accessory Sec (aSec) system comprised of SecA2, SecY2, and three to five additional proteins (Asps 1-5) that are required for substrate export. These adhesins typically have a 90 amino-acid-long signal peptide containing an elongated N-region and a hydrophobic core. Read More

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December 2018
1 Read

Epidemiology of invasive pneumococcal disease in indigenous and non-indigenous adults in northwestern Ontario, Canada, 2006-2015.

BMC Infect Dis 2018 Dec 4;18(1):621. Epub 2018 Dec 4.

Northern Ontario School of Medicine, Thunder Bay, ON, Canada.

Background: Despite the use of pneumococcal vaccines, indigenous populations are consistently disproportionately affected by invasive pneumococcal disease (IPD). With recent changes in Ontario's provincial pneumococcal vaccination program, we sought to evaluate the epidemiology and burden of IPD in northwestern Ontario (NWO) Canada - a region that contains a substantial (19.2%) indigenous population. Read More

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December 2018

Lefamulin: a promising new pleuromutilin antibiotic in the pipeline.

Expert Rev Anti Infect Ther 2018 Dec 4. Epub 2018 Dec 4.

a Duquesne University School of Pharmacy , 600 Forbes Ave; Pittsburgh , PA 15282.

Introduction: Community-acquired bacterial pneumonia (CABP) represents a significant clinical and financial burden within infectious disease. In the advent of increasing resistance from bacteria such as Streptococcus pneumoniae to available antibiotic therapies, there is a need for new drugs with novel mechanisms to treat such infections. Areas covered: Lefamulin, the first semi-synthetic pleuromutilin for systemic administration, is nearing completion of phase III studies for CABP; the manufacturer plans to file for a new drug application (NDA) in fourth-quarter 2018. Read More

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December 2018
4 Reads

Oxidative stress in the oral cavity is driven by individual-specific bacterial communities.

NPJ Biofilms Microbiomes 2018 27;4:29. Epub 2018 Nov 27.

1Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.

The term "bacterial dysbiosis" is being used quite extensively in metagenomic studies, however, the identification of harmful bacteria often fails due to large overlap between the bacterial species found in healthy volunteers and patients. We hypothesized that the pathogenic oral bacteria are individual-specific and they correlate with oxidative stress markers in saliva which reflect the inflammatory processes in the oral cavity. Temporally direct and lagged correlations between the markers and bacterial taxa were computed individually for 26 volunteers who provided saliva samples during one month (21. Read More

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November 2018
1 Read

Antimicrobial resistance in mastitis, respiratory and enteric bacteria isolated from ruminant animals from the Atlantic Provinces of Canada from 1994-2013.

Can Vet J 2018 Oct;59(10):1099-1104

Department of Health Management (Awosile, Heider, Saab, McClure), Diagnostic Services (Saab), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue Charlottetown, Prince Edward Island C1A 4P3.

Diagnostic laboratory antimicrobial susceptibility data for bacteria isolated from clinical samples of cattle, sheep, and goats from 1994 to 2013 were evaluated retrospectively. Among bacteria from bovine mastitis, and were the most commonly isolated organisms. and were commonly isolated from the respiratory tract, while isolates were frequently recovered from the intestinal tract. Read More

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October 2018

Acute and Chronic Suppurative Osteomyelitis of the Jaws: A 10-Year Review and Assessment of Treatment Outcome.

J Oral Maxillofac Surg 2018 Dec 12;76(12):2551-2558. Epub 2018 Jun 12.

Associate Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:

Purpose: To review cases of suppurative osteomyelitis of the jaws treated at the Massachusetts General Hospital (Boston, MA) over a 10-year period, evaluate specifics of disease presentation, and answer the clinical question: are there identifiable variables associated with treatment outcome?

Materials And Methods: A retrospective cohort study was completed using patients treated for suppurative osteomyelitis of the jaws at the Massachusetts General Hospital from April 2006 to October 2016. Inclusion criteria were a diagnosis of suppurative osteomyelitis of the jaw, age older than 18 years, and complete medical records. Patients with nonsuppurative disease, radiation history, or antiresorptive exposure were excluded. Read More

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December 2018

Homology modeling and molecular dynamic simulation of UDP-N-acetylmuramoyl-l-alanine-d-glutamate ligase (MurD) from Mycobacterium tuberculosis H37Rv using in silico approach.

Comput Biol Chem 2018 Nov 10;78:116-126. Epub 2018 Nov 10.

Department of Microbiology, Faculty of Science, University of Maiduguri, P.M.B. 1069, Nigeria; Department of Biotechnology, School of Engineering Technology, Sharda University, Greater Noida, India. Electronic address:

The present study aimed to identify the prospective inhibitors of MurD, a cytoplasmic enzyme that catalyzes the addition of d-glutamate to the UDP-N-acetylmuramoyl-l-alanine nucleotide precursor in Mycobacterium tuberculosis (MTB), using virtual screening, docking studies, pharmacokinetic analysis, Molecular Dynamic (MD) simulation, and Molecular Mechanics Generalized Born and Surface Area (MM-GBSA) analyses. The three dimensional (3D) structure was determined based on the homology technique using a template from Streptococcus agalactiae. The modeled structure had three binding sites, namely; substrate binding site (Val18, Thr19, Asp39, Asp40, Gly75, Asn147, Gln171 and His192), the ATP binding site (Gly123, Lys124, Thr125, Thr126, Glu166, Asp283, and Arg314) and the glutamic acid binding site (Arg382, Ser463, and Tyr470). Read More

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November 2018
2 Reads

Synthesis and mechanistic studies of diketo acids and their bioisosteres as potential antibacterial agents.

Eur J Med Chem 2018 Nov 22;163:67-82. Epub 2018 Nov 22.

Medicinal Chemistry Laboratory, Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. Electronic address:

A series of diketo esters and their pertinent bioisosteres were designed and synthesized as potent antibacterial agents by targeting methionine amino peptidases (MetAPs). In the biochemical assay against purified MetAPs from Streptococcus pneumoniae (SpMetAP1a), Mycobacterium tuberculosis (MtMetAP1c), Enterococcus faecalis (EfMetAP1a) and human (HsMetAP1b), compounds 3a, 4a and 5a showed more than 85% inhibition of all the tested MetAPs at 100 μM concentration. Compounds 4a and 5a also exhibited antibacterial potential with MIC values 62. Read More

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November 2018
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Antimicrobial-resistant pathogens in Canadian ICUs: results of the CANWARD 2007 to 2016 study.

J Antimicrob Chemother 2018 Nov 29. Epub 2018 Nov 29.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada.

Objectives: To describe the microbiology and antimicrobial resistance patterns of cultured samples acquired from Canadian ICUs.

Methods: From 2007 to 2016, tertiary care centres from across Canada submitted 42 938 bacterial/fungal isolates as part of the CANWARD surveillance study. Of these, 8130 (18. Read More

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November 2018
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Molecular docking and in silico studies of the physicochemical properties of potential inhibitors for the phosphotransferase system of Streptococcus mutans.

Arch Oral Biol 2018 Nov 22;98:164-175. Epub 2018 Nov 22.

Faculty of Dentistry, University of Antioquia- UdeA, 64 Street No. 52-59, Block 31, Oral Microbiology Laboratory No. 216, Health Area, Medellin, Colombia. Electronic address:

This study identified potential inhibitory compounds of the phosphoenolpyruvate-sugar. Phosphotransferase system of S. mutans, specifically enzyme II mannose transporter (EII) in its subunits IIA, IIB and IIC by means of a selection protocol and in silico molecular analysis. Read More

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November 2018
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Chemical composition of essential oils from different parts of Protium heptaphyllum (Aubl.) Marchand and their in vitro antibacterial activity.

Nat Prod Res 2018 Nov 30:1-6. Epub 2018 Nov 30.

d Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro, Uberlândia, MG, Brazil.

In Brazilian folk medicine, Protium heptaphyllum is used to treat inflammatory conditions and to hasten wound repair. This paper aims to investigate the chemical composition and the in vitro antibacterial effects of the essential oils (EOs) obtained from P. heptaphyllum leaves and ripe and unripe fruits against a representative panel of oral pathogens. Read More

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November 2018
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Correlation between Streptococcus bovis bacteremia and density of cows in Galicia, northwest of Spain.

Infection 2018 Nov 29. Epub 2018 Nov 29.

Infectious Diseases Unit, Hospital Universitario Lucus Augusti, Lugo, Spain.

Background: There are few data on the epidemiology of infections caused by Streptococcus bovis (Sb). Some studies suggest that both residence in rural areas and contact with livestock could be potential risk factors.

Methods: We performed a retrospective study for the period 2005-2016 of all cases of bacteremia caused by Sb in Galicia (a region in the northwest of Spain). Read More

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November 2018
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