6,139 results match your criteria Streptococcus Group D Infections


Antimicrobial Resistance, Virulence Genes, and Biofilm Formation Capacity Among From Yaks in Aba Tibetan Autonomous Prefecture, China.

Front Microbiol 2020 12;11:1250. Epub 2020 Jun 12.

Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.

Yaks provide necessities such as meat and milk for Tibetans living at high altitudes on and around the Qinghai-Tibetan Plateau. Enterococci are ubiquitous members of the animal gut microbiota that can cause biofilm-associated opportunistic infections. Meanwhile, multidrug-resistant also poses a serious threat to public health. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304059PMC

Molecular tracking of pathogens in central venous catheter.

J Vasc Access 2020 Jun 26:1129729820934354. Epub 2020 Jun 26.

Department of Social and Preventive Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Background: Central venous catheter-related bloodstream infection is an important adverse event in health care. Molecular methods are not yet substitutive of microbiological in the detection of the pathogens responsible for the infection, but they can help in the epidemiological characterization.

Aim: To detect bacteria by polymerase chain reaction, from material extracted from the tip of central catheters of patients suspected of infection at the intensive care unit. Read More

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http://dx.doi.org/10.1177/1129729820934354DOI Listing

What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?

BMC Immunol 2020 Jun 22;21(1):38. Epub 2020 Jun 22.

Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.

Background: Oral fibroblast immunological responses to bacterial stimuli are well known. However, there are few studies about pulp fibroblasts from deciduous teeth (HDPF) responses, which are important for the treatment of pulp infections in children. The aim of this study was to evaluate expression and production of inflammatory cytokines and chemokines by HDPF when challenged with bacterial antigens normally present in advanced caries lesions. Read More

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http://dx.doi.org/10.1186/s12865-020-00367-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310245PMC

Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Škorničk.

Antibiotics (Basel) 2020 Jun 18;9(6). Epub 2020 Jun 18.

Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.

The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of were investigated. The GC/MS analysis showed that β-pinene, -β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. Read More

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http://dx.doi.org/10.3390/antibiotics9060334DOI Listing

Prevalence of an Intestinal ST40 over Other Strains in the Gut Environment of Mice Fed Different High Fat Diets.

Int J Mol Sci 2020 Jun 18;21(12). Epub 2020 Jun 18.

Área de Microbiología, Departamento de Ciencias de la Salud, Universidad de Jaén, Paraje de Las Lagunillas s/n, 23071 Jaén, Spain.

is a commensal bacterium with specific strains involved in opportunistic and nosocomial infections. Therefore, it is important to know how the strains of this species are selected in the gut. In this study, fifteen strains, isolated over twelve weeks from the faeces of mice fed standard chow or one of three high fat diets enriched with extra virgin olive oil, refined olive oil or butter were subjected to a genetic "Multilocus Sequence Typing" study that revealed the presence of mainly two genotypes, ST9 and ST40, the latter one prevailing at the end of the research. Read More

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http://dx.doi.org/10.3390/ijms21124330DOI Listing

A retrospective observational study on enterococcal bacteraemia and endocarditis at a regional hospital in New South Wales, Australia.

Authors:
N Lwin A Bannan

Infect Dis Health 2020 Jun 16. Epub 2020 Jun 16.

Department of Medicine, Port Macquarie Base Hospital, NSW, 2444, Australia; UNSW Medicine Phase 2 Convener Rural Clinical School, Port Macquarie, NSW, 2444, Australia.

Background: Enterococcal infection poses a major clinical problem due to increasing antibiotic resistance and rising numbers of health care related infections. It is also associated with high morbidity and mortality. The aim of this study is to examine demographic characteristics, co-morbidities and clinical outcomes of the patients as well as susceptibility spectrum of all Enterococcal bacteraemia and endocarditis. Read More

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http://dx.doi.org/10.1016/j.idh.2020.05.004DOI Listing

Probiotics: an Antibiotic Replacement Strategy for Healthy Broilers and Productive Rearing.

Probiotics Antimicrob Proteins 2020 Jun 17. Epub 2020 Jun 17.

Department of Microbiology, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Pathogens develop resistance to antibiotics at a rate much faster than the discovery of new antimicrobial compounds. Reports of multidrug-resistant bacteria isolated from broilers, and the possibility that these strains may spread diseases amongst humans, prompted many European countries to ban the inclusion of antibiotics in feed. Probiotics added to broiler feed controlled a number of bacterial infections. Read More

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http://dx.doi.org/10.1007/s12602-020-09640-zDOI Listing

Involvement of chromosomally encoded homologs of the RRNPP protein family in biofilm formation and UTI pathogenesis.

J Bacteriol 2020 Jun 15. Epub 2020 Jun 15.

Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045

is an opportunistic pathogen capable of causing infections including endocarditis and urinary tract infections (UTI). One of the well characterized quorum sensing pathways in involves coordination of the conjugal transfer of pheromone-responsive plasmids by PrgX, a member of the RRNPP protein family. Members of this protein family in various have also been shown to contribute to numerous cellular processes including sporulation, competence, conjugation, nutrient sensing, biofilm formation and virulence. Read More

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http://dx.doi.org/10.1128/JB.00063-20DOI Listing

Impacts of a novel defensive symbiosis on the nematode host microbiome.

BMC Microbiol 2020 Jun 15;20(1):159. Epub 2020 Jun 15.

Department of Zoology, University of Oxford, Oxford, OX1 3SZ, UK.

Background: Bacteria adapted to live within animals can protect their hosts against harmful infections. Beyond antagonism with pathogens, a 'defensive' bacterial symbiont could engage in additional interactions with other colonizing micro-organisms. A single bacterium might thus have cascading ecological impacts on the whole microbiome that are rarely investigated. Read More

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http://dx.doi.org/10.1186/s12866-020-01845-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296725PMC

Microbiology and risk factors for gram-positive Cocci bacteremia in biliary infections.

Hepatobiliary Pancreat Dis Int 2020 Jun 2. Epub 2020 Jun 2.

Division of Gastroenterology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea.

Background: The rapid antibiotics treatment targeted to a specific pathogen can improve clinical outcomes of septicemia. We aimed to evaluate the clinical characteristics and outcomes of biliary septicemia caused by cholangitis or cholecystitis according to causative organisms.

Methods: We performed a retrospective cohort study in 151 patients diagnosed with cholangitis or cholecystitis with bacterial septicemia from January 2013 to December 2015. Read More

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http://dx.doi.org/10.1016/j.hbpd.2020.05.006DOI Listing

Mechanism of Eravacycline Resistance in Clinical Isolates From China.

Front Microbiol 2020 25;11:916. Epub 2020 May 25.

Shenzhen Key Laboratory for Endogenous Infections, Department of Infectious Diseases, Shenzhen Nanshan People's Hospital, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.

Opportunistic infections caused by multidrug-resistant strains are a significant clinical challenge. Eravacycline (Erava) is a synthetic fluorocycline structurally similar to tigecycline (Tige) that exhibits robust antimicrobial activity against Gram-positive bacteria. This study investigated the antimicrobial activity and heteroresistance risk of Eravacycline (Erava) in clinical isolates from China along with the mechanism of Erava resistance. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261854PMC

Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer: Focus on short and long-term outcomes.

World J Gastroenterol 2020 May;26(20):2498-2513

Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy.

Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal tract. These dynamic communities, the environment and their metabolites constitute the microbiota. Growing data suggests a causal role of a dysbiotic microbiota in several pathologies, such as metabolic and neurological disorders, immunity dysregulations and cancer, especially the well-studied colorectal cancer development. Read More

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http://dx.doi.org/10.3748/wjg.v26.i20.2498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265137PMC

Characterization of clinical enterococci isolates, focusing on the vancomycin-resistant enterococci in a tertiary hospital in China: based on the data from 2013 to 2018.

BMC Infect Dis 2020 May 19;20(1):356. Epub 2020 May 19.

Department of Clinical Laboratory, Jinling Hospital, Nanjing University School of Medicine, Nanjing University, 305# East Zhongshan Road, Qinhuai District, Nanjing, Jiangsu Province, 210008, P. R. China.

Background: Vancomycin-resistant Enterococcus spp. (VRE) have spread all over the world. The present study aims to investigate the species distribution, specimen type and susceptibilities of Enterococcal species collected from Nanjing Drum Tower Hospital from 2013 to 2018. Read More

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http://dx.doi.org/10.1186/s12879-020-05078-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285731PMC

Occurrence and determinants of enterococcal bloodstream infections: a population-based study.

Infect Dis (Lond) 2020 Jun 9:1-6. Epub 2020 Jun 9.

Department of Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Australia.

Although enterococci are common causes of bloodstream infections (BSIs), few studies have examined their epidemiology in non-selected populations. To examine the incidence and risk factors for development of enterococcal BSI. Surveillance for incident enterococcal BSI was conducted among all residents of the western interior of British Columbia, Canada during 2011-2018. Read More

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http://dx.doi.org/10.1080/23744235.2020.1774074DOI Listing

Isolation, characterization, and comparative genomic analysis of a phage infecting high-level aminoglycoside-resistant (HLAR) .

PeerJ 2020 21;8:e9171. Epub 2020 May 21.

Life Sciences, Texas A&M University-Corpus Christi, Corpus Christi, TX, United States of America.

is a genus of Gram-positive bacteria that are commensal to the gastrointestinal tracts of humans but some species have been increasingly implicated as agents of nosocomial infections. The increase in infections and the spread of antibiotic-resistant strains have contributed to renewed interest in the discovery of phages. The aims of this study were (1) the isolation, characterization, and genome sequencing of a phage capable of infecting an antibiotic-resistant strain, and (2) the comparative genomic analysis of publicly-available phages. Read More

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http://dx.doi.org/10.7717/peerj.9171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246028PMC

New insight into the association between bile infection and clinically relevant pancreatic fistula in patients undergoing pancreatoduodenectomy.

J Hepatobiliary Pancreat Sci 2020 Jun 7. Epub 2020 Jun 7.

Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: The association between bacterial infection and clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatoduodenectomy (PD) has not been fully elucidated.

Methods: Microbiological data for intraoperative bile culture (BC) and drain culture on postoperative day 4 (DC) were collected. The study population was classified into the following 3 groups: P1 (positive BC and DC), P2 (positive BC and negative DC), and N (negative BC). Read More

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http://dx.doi.org/10.1002/jhbp.781DOI Listing

The ongoing challenge of vancomycin-resistant and in Europe: an epidemiological analysis of bloodstream infections.

Emerg Microbes Infect 2020 Dec;9(1):1180-1193

Unit 37: Nosocomial Infections, Surveillance of Antimicrobial Resistance and Consumption, Robert Koch Institute, Berlin, Germany.

Vancomycin-resistant enterococci infections are of great public health significance due to limited therapeutic options. We investigated epidemiological trends and risk factors of vancomycin resistance in enterococci isolates from patients with bloodstream infections in the EU/EEA from 2012 to 2018. Routine vancomycin susceptibility data of clinical (n = 67,022) and (n = 103,112) blood isolates from the European Antimicrobial Resistance Surveillance Network were analysed using descriptive statistics and multivariable regression analyses. Read More

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http://dx.doi.org/10.1080/22221751.2020.1769500DOI Listing
December 2020

Analysis of Susceptibility to Selected Antibiotics in and Causing Urinary Tract Infections in Kidney Transplant Recipients over 8 Years: Single-Center Study.

Antibiotics (Basel) 2020 May 26;9(6). Epub 2020 May 26.

Department of Transplantation Medicine, Nephrology, Internal Diseases, T. Orłowski Institute of Transplantation, Medical University of Warsaw, 59 Nowogrodzka Street, 02-006 Warsaw, Poland.

Urinary tract infections (UTIs) are the most common bacterial infections among kidney transplant (KTX) recipients. The purpose of this study was to analyze antimicrobial resistance (AMR) in four most common pathogens responsible for UTIs in KTX recipients and determine risk factors (RF) for resistance in the same group. Analyzed antibiograms were based on urine samples positive for bacterial growth of 10 colony-forming units (CFU)/mL obtained from hospitalized adult KTX recipients presenting with UTI symptoms upon admission to the center in years 2011-2018. Read More

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http://dx.doi.org/10.3390/antibiotics9060284DOI Listing

The roles of the site-2 protease Eep in .

J Bacteriol 2020 May 26. Epub 2020 May 26.

Department of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

In , the site-2 protease Eep generates sex pheromones, including cAM373. Intriguingly, in a peptide similar to cAM373, named cAM373_SA, is produced from the gene. Here, we report that the staphylococcal Eep homolog is not only responsible for the production of cAM373_SA but also critical for staphylococcal virulence. Read More

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http://dx.doi.org/10.1128/JB.00046-20DOI Listing
May 2020
2.808 Impact Factor

Investigation of Gelatinase Gene Expression and Growth of Clinical Isolates in Biofilm Models.

Turk J Pharm Sci 2019 Sep 10;16(3):356-361. Epub 2019 Jul 10.

Gazi University, Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.

Objectives: is the major reason for biofilm-related infections and it also interacts with in biofilms. Gelatinase (gelE) enzyme is an important virulence factor of for biofilm formation. This study aimed to compare the biofilm producing isolates from urine and urinary catheters. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.69783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227953PMC
September 2019

Performance of commercial methods for linezolid susceptibility testing of Enterococcus faecium and Enterococcus faecalis.

J Antimicrob Chemother 2020 May 25. Epub 2020 May 25.

CHU de Rennes, Service de Bactériologie et Hygiène Hospitalière, Rennes, France.

Background: Linezolid-resistant enterococci (LRE) causing infections that are challenging to treat are rising, highlighting the need for reliable screening of LRE clinical isolates.

Objectives: To evaluate the ability of the broth microdilution (BMD) method for LRE detection and to assess the performance of seven commercially available techniques for linezolid susceptibility testing.

Methods: A collection of 100 clinical isolates (80 Enterococcus faecium and 20 Enterococcus faecalis), including 20 optrA-positive isolates, 17 poxtA-positive isolates and 1 optrA/poxtA-positive E. Read More

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http://dx.doi.org/10.1093/jac/dkaa180DOI Listing

Molecular characteristics and risk factors associated with linezolid-resistant Enterococcus faecalis infection in Southwest China.

Authors:
Jiaqi Zou Yun Xia

J Glob Antimicrob Resist 2020 May 18. Epub 2020 May 18.

Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Linezolid is one of the last lines of defense for Gram-positive bacteria, and the increasing emergence of linezolid-resistant enterococci (LRE) has become an important problem in nosocomial infections.

Objective: To explore the mechanism of linezolid resistance and analyze the risk factor for the infection with LRE.

Method: The known resistance mechanisms of linezolid were detected by PCR. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.03.027DOI Listing

whISOBAX Inhibits Bacterial Pathogenesis and Enhances the Effect of Antibiotics.

Antibiotics (Basel) 2020 May 19;9(5). Epub 2020 May 19.

Department of Chemistry and Food Science, Framingham State University, Framingham, MA 01701, USA.

As bacteria are becoming more resistant to commonly used antibiotics, alternative therapies are being sought. whISOBAX (WH) is a witch hazel extract that is highly stable (tested up to 2 months in 37 °C) and contains a high phenolic content, where 75% of it is hamamelitannin and traces of gallic acid. Phenolic compounds like gallic acid are known to inhibit bacterial growth, while hamamelitannin is known to inhibit staphylococcal pathogenesis (biofilm formation and toxin production). Read More

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http://dx.doi.org/10.3390/antibiotics9050264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277200PMC

Draft Genome Sequence of Antibiotic-Resistant Enterococcus faecalis Strain UMB0843, Isolated from the Female Urinary Tract.

Microbiol Resour Announc 2020 May 14;9(20). Epub 2020 May 14.

Bioinformatics Program, Loyola University Chicago, Chicago, Illinois, USA

Here, we introduce the 2.8-Mbp draft genome of strain UMB0843, isolated from the female urinary tract. is a leading cause of nosocomial infections, and many strains are often resistant to multiple antibiotics. Read More

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http://dx.doi.org/10.1128/MRA.00407-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225553PMC

Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of and Growth and Biofilm Formation.

Molecules 2020 May 12;25(10). Epub 2020 May 12.

Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.

Methicillin-resistant (MRSA) and vancomycin-resistant (VRE) have been deemed as serious threats by the CDC. Many chronic MRSA and VRE infections are due to biofilm formation. Biofilm are considered to be between 10-10,000 times more resistant to antibiotics, and therefore new chemical entities that inhibit and/or eradicate biofilm formation are needed. Read More

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http://dx.doi.org/10.3390/molecules25102277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287929PMC
May 2020
2.416 Impact Factor

Chemical Compositions, Mosquito Larvicidal and Antimicrobial Activities of Leaf Essential Oils of Eleven Species of Lauraceae from Vietnam.

Plants (Basel) 2020 May 10;9(5). Epub 2020 May 10.

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.

The Lauraceae is a family rich in aromatic and medicinal plants. Likewise, essential oils derived from members of this family have demonstrated a myriad of biological activities. It is hypothesized that members of the Lauraceae from Vietnam will yield essential oils that may be useful in controlling mosquito populations and treating microbial infections. Read More

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http://dx.doi.org/10.3390/plants9050606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284511PMC

A novel comprehensive efficacy test for textiles intended for use in the healthcare setting.

J Microbiol Methods 2020 Jun 5;173:105937. Epub 2020 May 5.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA. Electronic address:

Soft surfaces, including textiles are found throughout healthcare settings. Pathogens can survive for long periods of time on textiles, and can be transferred to and from the skin. Antimicrobial fabrics are used as an engineering control to prevent infection. Read More

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http://dx.doi.org/10.1016/j.mimet.2020.105937DOI Listing

Postpartum mastitis in the breastfeeding women and antimicrobial resistance of responsible pathogens in ukraine: results a multicenter study.

Wiad Lek 2020 ;73(5):895-903

Brovarska Multidisciplinary District Hospital, Brovary, Ukraine.

Objective: The aim: To obtain the prevalence of mastitis in the breastfeeding women and antimicrobial resistance of responsible pathogens in Ukraine.

Patients And Methods: Materials and methods: A retrospective multicenter cohort study was based on surveillance data for Postpartum Mastitis and included 18,427 breastfeeding women's who gave birth in 11 regional hospitals of Ukraine.

Results: Results: 22. Read More

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January 2020

Endodontic-Like Oral Biofilms as Models for Multispecies Interactions in Endodontic Diseases.

Microorganisms 2020 May 6;8(5). Epub 2020 May 6.

Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.

Oral bacteria possess the ability to form biofilms on solid surfaces. After the penetration of oral bacteria into the pulp, the contact between biofilms and pulp tissue may result in pulpitis, pulp necrosis and/or periapical lesion. Depending on the environmental conditions and the availability of nutrients in the pulp chamber and root canals, mainly Gram-negative anaerobic microorganisms predominate and form the intracanal endodontic biofilm. Read More

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http://dx.doi.org/10.3390/microorganisms8050674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285038PMC

Biological characteristics and whole-genome analysis of the phage PEf771.

Can J Microbiol 2020 May 6:1-16. Epub 2020 May 6.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China.

is a common pathogen causing refractory periapical periodontitis and secondary intraradicular infections. In this study, YN771 isolated from a re-treated root canal at a stomatology department was used as the host bacterium and was co-cultured with wastewater from the same department and patient samples to isolate a phage that lyses . We studied the biological and genomic characteristics of this phage. Read More

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http://dx.doi.org/10.1139/cjm-2019-0336DOI Listing

Urinary Tract Infections among Indonesian Pregnant Women and Its Susceptibility Pattern.

Infect Dis Obstet Gynecol 2020 21;2020:9681632. Epub 2020 Apr 21.

Faculty of Medicine Universitas Indonesia, Indonesia.

Pregnant women are usually at risk of urinary tract infections (UTIs) such as asymptomatic bacteriuria. In the current multidrug-resistance era, appropriate diagnosis and treatment should be provided to avoid complications in pregnant women in developing countries, which have limited facilities, such as Indonesia. The aim of this study was to evaluate in vitro susceptibility tests. Read More

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http://dx.doi.org/10.1155/2020/9681632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191430PMC

Glycerol Monolaurate, an Analogue to a Factor Secreted by , Is Virucidal against Enveloped Viruses, Including HIV-1.

mBio 2020 05 5;11(3). Epub 2020 May 5.

Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

The vaginal microbiota influences sexual transmission of human immunodeficiency virus type 1 (HIV-1). Colonization of the vaginal tract is normally dominated by species. Both and may secrete reutericyclin, which inhibits the growth of a variety of pathogenic bacteria. Read More

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http://dx.doi.org/10.1128/mBio.00686-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201201PMC

High Potential of Bacterial Adhesion on Block Bone Graft Materials.

Materials (Basel) 2020 May 1;13(9). Epub 2020 May 1.

Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Bone graft infections represent a challenge in daily clinics, resulting in increased patient discomfort and graft removal. The aim of this study was to investigate the initial adhesion of five representative pathogens on three different block bone graft materials (xenogeneic, alloplastic and allogeneic) and to assess if chlorhexidine (CHX) can effectively control the initial bacterial adhesion. Three different block bone grafting materials (Tutobone®, Endobon® and human spongiosa) were incubated with , , , and in the presence or absence of 0. Read More

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http://dx.doi.org/10.3390/ma13092102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254222PMC

Synthetic Oligomers Mimicking Capsular Polysaccharide Diheteroglycan are Potential Vaccine Candidates against Encapsulated Infections.

ACS Infect Dis 2020 May 15. Epub 2020 May 15.

Division of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich 80337, Germany.

Infections caused by spp. are a major concern in the clinical setting. In , the capsular polysaccharide diheteroglycan (DHG), composed of ß-d-galactofuranose-(1 → 3)-ß-d-glucopyranose repeats, has been described as an important virulence factor and as a potential vaccine candidate against encapsulated strains. Read More

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http://dx.doi.org/10.1021/acsinfecdis.0c00063DOI Listing

Antibiotic guidelines coupled with selective reporting of antibiograms.

Med Mal Infect 2020 Apr 29. Epub 2020 Apr 29.

Réso-Infectio-PACA-Est, Nice, France; Faculté de médecine, université Côte d'Azur, Nice, France; Polyclinique Les Fleurs, avenue Frédéric-Mistral, 83190 Ollioules, France. Electronic address:

Objectives: We reported the impact of internal guidelines coupled with selective reporting of antibiotic susceptibility tests (srAST) on antibiotic adequacy in healthcare facilities.

Methods: This prospective study involved clinicians from three clinics with medical and surgical activities employing a full-time infectious disease (ID) specialist. Internal guidelines were updated in 2016. Read More

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http://dx.doi.org/10.1016/j.medmal.2020.04.018DOI Listing

In vivo synergism of ampicillin, gentamicin, ceftaroline and ceftriaxone against Enterococcus faecalis assessed in the Galleria mellonella infection model.

J Antimicrob Chemother 2020 May 1. Epub 2020 May 1.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.

Background: The unfavourable safety profile of aminoglycosides and the synergistic effects observed in vitro have prompted the development of novel dual β-lactam therapies, e.g. ampicillin/ceftriaxone or ampicillin/ceftaroline, for the treatment of Enterococcus faecalis endocarditis. Read More

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http://dx.doi.org/10.1093/jac/dkaa129DOI Listing

In vitro activity of omadacycline against pathogens isolated from Mainland China during 2017-2018.

Eur J Clin Microbiol Infect Dis 2020 Apr 30. Epub 2020 Apr 30.

Institute of Antibiotics, Huashan Hospital, Fudan University, 12 M. Wulumuqi Rd., Shanghai, 200040, People's Republic of China.

Antibiotic resistance of bacterial pathogens isolated in China is a major concern. Omadacycline is a novel tetracycline derivative that has been approved for use in skin infections and community-acquired pneumonia. This study was conducted to determine the in vitro activity of omadacycline against a large collection of patient isolate medical centers across Mainland China. Read More

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http://dx.doi.org/10.1007/s10096-020-03877-wDOI Listing
April 2020
2.668 Impact Factor

Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens in Urinary Tract Infections in University Hospital of Campania "Luigi Vanvitelli" between 2017 and 2018.

Antibiotics (Basel) 2020 04 28;9(5). Epub 2020 Apr 28.

Department of Experimental Medicine, University of Study of Campania"Luigi Vanvitelli", 80138 Naples, Italy.

Urinary tract infections (UTIs) are the most common and expensive health problem globally. The treatment of UTIs is difficult owing to the onset of antibiotic-resistant bacterial strains. The aim of this study was to define the incidence of infections, identify the bacteria responsible, and identify the antimicrobial resistance profile. Read More

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http://dx.doi.org/10.3390/antibiotics9050215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277346PMC

Daptomycin in the treatment of enterococcal bloodstream infections and endocarditis: a EUCAST position paper.

Clin Microbiol Infect 2020 Apr 27. Epub 2020 Apr 27.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet and Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.

Scope: This position paper describes the view adopted by EUCAST on the role of daptomycin in the treatment of serious infections caused by Enterococcus species.

Background: High-dose daptomycin is considered effective in the treatment of enterococcal bloodstream infection (BSI) and endocarditis, although published clinical experience with the latter condition is limited.

Methods: EUCAST reviewed the available published data on pharmacokinetics-pharmacodynamics (PK-PD), resistance selection, clinical efficacy and safety for the use of 10-12 mg/kg/day of daptomycin for these conditions, noting that the doses licensed by the European Medicines Agency are only 4-6 mg/kg/day, and only for infections caused by Staphylococcus aureus. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.04.027DOI Listing

In vitro synergistic effect of retapamulin with erythromycin and quinupristin against Enterococcus faecalis.

J Antibiot (Tokyo) 2020 Apr 28. Epub 2020 Apr 28.

College of Medical Science, Daegu Haany University, Gyeongsan, Republic of Korea.

To find a therapeutic alternative for the treatment of skin and soft tissue infections, we evaluated the effects of combinations of retapamulin with macrolide, lincosamide, and streptogramin (MLS) antibiotics against Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecium, and Enterococcus faecalis. Using both the disk diffusion test and checkerboard assay, we initially examined the effects of combinations of retapamulin with MLS antibiotics against standard strains of these species. Combinations of retapamulin with erythromycin, quinupristin/dalfopristin and quinupristin showed synergistic activity against E. Read More

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http://dx.doi.org/10.1038/s41429-020-0312-7DOI Listing

Complete Structure of the Enterococcal Polysaccharide Antigen (EPA) of Vancomycin-Resistant Enterococcus faecalis V583 Reveals that EPA Decorations Are Teichoic Acids Covalently Linked to a Rhamnopolysaccharide Backbone.

mBio 2020 04 28;11(2). Epub 2020 Apr 28.

Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France

All enterococci produce a complex polysaccharide called the nterococcal olysaccharide ntigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for virulence, conferring resistance to phagocytosis during the infection. Read More

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http://dx.doi.org/10.1128/mBio.00277-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188991PMC

Mosquito Larvicidal Activity, Antimicrobial Activity, and Chemical Compositions of Essential Oils from Four Species of Myrtaceae from Central Vietnam.

Plants (Basel) 2020 Apr 22;9(4). Epub 2020 Apr 22.

Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA.

Mosquitoes are important vectors of several diseases, and control of these insects is imperative for human health. Insecticides have proven useful in controlling mosquito populations, but insecticide resistance and environmental concerns are increasing. Additionally, emerging and re-emerging microbial infections are problematic. Read More

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http://dx.doi.org/10.3390/plants9040544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238417PMC

Interregional spread in Spain of linezolid-resistant Enterococcus spp. isolates carrying the optrA and poxtA genes.

Int J Antimicrob Agents 2020 Jun 22;55(6):105977. Epub 2020 Apr 22.

Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain; Spanish Network for Research in Infectious Diseases (REIPI RD16/0016), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

The emergence of linezolid-resistant Enterococcus spp. (LRE) due to transferable resistance determinants is a matter of concern. To understand the contribution of the plasmid-encoded optrA and poxtA genes to the emergence of LRE, clinical isolates from different Spanish hospitals submitted to the Spanish Reference Laboratory from 2015-2018 were analysed. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.105977DOI Listing

[Clinical Features of Infection within 100 days after Hematopoietic Stem Cell Transplantation in 313 patients with Hematologic Diseases].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):602-608

Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002,Jiangsu Province,

Objective: To analyze the clinical characteristics of infection within 100 days after hematopoietic stem cell transplantation (HSCT) in patients with hematologic disease.

Methods: The culture results of 313 HSCT patients infected in the hematology department of our hospital from January 2013 to January 2019 were collected, and the infection incidence, pathogen distribution, drug susceptibility test results and infection risk factors out of them all were analyzed.

Results: Among 313 HSCT patients, infection occurred within 100 days in 262(83. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.041DOI Listing

[Clinical Significance of Stone Cultures for Patients Undergoing Transurethral Lithotripsy].

Hinyokika Kiyo 2020 Mar;66(3):73-76

The Department of Urology, Nara Medical University.

This study aimed to evaluate the concordance of the microbiologic findings of preoperative urine cultures and intraoperative stone cultures in patients undergoing transurethral lithotripsy (TUL). A total of 164 patients treated with TUL for whom preoperative urine cultures and intraoperative stone cultures were performed were included in this study. The preoperative urine cultures were positive in 57 patients (34. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_3_73DOI Listing

The Influence of Enterococcus faecalis as a Dental Root Canal Pathogen on Endodontic Treatment: A Systematic Review.

Cureus 2020 Mar 13;12(3):e7257. Epub 2020 Mar 13.

Endodontics, King Abdulaziz University, Jeddah, SAU.

Endodontic treatment failure may occur due to different causes such as persistence of bacteria, root canals that are poorly cleaned and obturated, improper coronal seal (leakage), and untreated canals (missed canals). The main reason for endodontic failure is the presence of some species of bacteria inside the root canal system such as Enterococcus (E.) faecalis. Read More

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http://dx.doi.org/10.7759/cureus.7257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152576PMC

Heteroresistant Bacteria Detected by an Extended Raman-Based Antibiotic Susceptibility Test.

Anal Chem 2020 Jun 18. Epub 2020 Jun 18.

Analytical Chemistry, Technical University of Munich, Munich 80333, Germany.

Worldwide, multiresistant bacterial strains are emerging at unprecedented rates. This development seriously threatens the ability of humanity to treat even common infections, resulting in disability and death. Furthermore, this development endangers all medical achievements including cancer therapy or organ transplantations. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b05387DOI Listing

Molecular and functional analysis of the novel cfr(D) linezolid resistance gene identified in Enterococcus faecium.

J Antimicrob Chemother 2020 Jul;75(7):1699-1703

Université de Rennes 1, Inserm U1230, Rennes, France.

Objectives: To characterize the novel cfr(D) gene identified in an Enterococcus faecium clinical isolate (15-307.1) collected from France.

Methods: The genome of 15-307. Read More

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http://dx.doi.org/10.1093/jac/dkaa125DOI Listing

Viscoelastic behaviour of hyaluronic acid formulations containing carvacrol prodrugs with antibacterial properties.

Int J Pharm 2020 May 8;582:119306. Epub 2020 Apr 8.

Department of Pharmacy, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti Scalo (CH), Italy.

In this paper, we report the development and viscoelastic properties of hyaluronic acid formulations (HA, HA, and HA, containing 0.5, 3, and 6% HA, respectively) loaded with carvacrol prodrugs (WSCP) with antibacterial properties. Notably, antimicrobial studies revealed that WSCP1-2 in both HA and HA formulations showed the best minimum inhibitory concentration (MIC) values against Enterococcus faecium (128 mg/L) and Enterococcus faecalis (256 mg/L) compared to those of carvacrol alone or in formulations with HA. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119306DOI Listing

Five compelling UTI questions after kidney transplant.

World J Urol 2020 Apr 7. Epub 2020 Apr 7.

Department of Urology, Shahid Labbafinejad Medical Center, Tehran, Iran.

Purpose: Urinary tract infection (UTI) is the most common bacterial infection among infectious complications in kidney transplant recipients (KTR). After transplantation, infections can result from surgical complications, donor-derived infections, pre-existing recipient infections, and nosocomial infections. Post-transplant infection is still a major cause of morbidity, mortality, graft dysfunction and rejection. Read More

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http://dx.doi.org/10.1007/s00345-020-03173-4DOI Listing
April 2020
2.666 Impact Factor