6,168 results match your criteria Streptococcus Group D Infections


Linezolid Consumption Facilitates the Development of Linezolid Resistance in Enterococcus faecalis in a Tertiary-Care Hospital: A 5-Year Surveillance Study.

Microb Drug Resist 2019 Feb 14. Epub 2019 Feb 14.

1 Department of Infectious Diseases and Shenzhen Key Lab for Endogenous Infection, Shenzhen Nanshan Hospital of Shenzhen University, Nanshan District, Shenzhen, China.

Although case reports and clinical studies of linezolid (LZD)-resistant Enterococcus faecalis (LREF) have gradually increased in recent years, the relationship between LZD resistance and antibiotic consumption in hospital settings still remains unclear. In this study, we aimed to investigate the dynamic relationship between the yearly detection frequency of LREF clinical isolates and yearly consumption of LZD and vancomycin (VCM) over a 5-year period in a Chinese hospital setting. Antibiotic consumption data (LZD and VCM) from 2011 to 2015 were obtained from a computerized database and recalculated as the defined daily doses (DDDs) per 100 bed-days (DBD). Read More

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http://dx.doi.org/10.1089/mdr.2018.0005DOI Listing
February 2019

Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis.

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

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http://dx.doi.org/10.3390/tropicalmed4010035DOI Listing
February 2019

In vitro activity of oritavancin alone or in combination against vancomycin-susceptible and -resistant enterococci.

J Antimicrob Chemother 2019 Feb 8. Epub 2019 Feb 8.

College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

Objectives: The optimal treatment for serious infections due to Enterococcus spp. is unknown although combination antimicrobial therapy is often recommended for invasive infections to achieve bactericidal activity and improve clinical outcomes. Oritavancin is a novel lipoglycopeptide agent with in vitro activity against enterococci, including vancomycin-resistant VanA-type Enterococcus faecium. Read More

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http://dx.doi.org/10.1093/jac/dkz010DOI Listing
February 2019

Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus strains.

Med Chem 2019 Feb 8. Epub 2019 Feb 8.

Institute of Biochemistry, Ernst-Moritz-Arndt University Greifswald, Felix-Hausdorff-Str. 4, 17487 Greifswald. Germany.

Background: Due to emerging resistances against antibiotics there is a strong need to find novel antibacterial agents with a novel structure to prevent early resistance developments.

Objective: Bisindole compounds with antibacterial activities which formally result from the reaction of an aldehyde with indole motivated to investigate the reaction of a dialdehyde and indole to give novel structures with potential antibacterial activities.

Method: Compounds were yielded by chemical synthesis and purified using column chromatography. Read More

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http://dx.doi.org/10.2174/1573406415666190208170126DOI Listing
February 2019

Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria.

J Agric Food Chem 2019 Feb 12. Epub 2019 Feb 12.

Institute of Food Science Research (CIAL) , CSIC-UAM , C/Nicolás Cabrera 9 , 28049 Madrid , Spain.

Findings concerning the antiadhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against Gram-negative ( Escherichia coli ATCC 53503 and DSM 10791) and Gram-positive ( Enterococcus faecalis 04-1) bacteria in T24 cells are reported. A-Type procyanidins (A2 and cinnamtannin B-1) exhibited antiadhesive activity (at concentrations ≥250 μM), a feature that was not observed for B-type procyanidins (B2). The metabolites hippuric acid and α-hydroxyhippuric acid also showed effective results at concentrations ≥250 μM. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b05625DOI Listing
February 2019

PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis.

PLoS Pathog 2019 Feb 11;15(2):e1007571. Epub 2019 Feb 11.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, United States of America.

Bacterial pathogens have evolved strategies that enable them to invade tissues and spread within the host. Enterococcus faecalis is a leading cause of local and disseminated multidrug-resistant hospital infections, but the molecular mechanisms used by this non-motile bacterium to penetrate surfaces and translocate through tissues remain largely unexplored. Here we present experimental evidence indicating that E. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007571DOI Listing
February 2019

Microbiology of polymicrobial prosthetic joint infection.

Diagn Microbiol Infect Dis 2019 Jan 15. Epub 2019 Jan 15.

Divisions of Clinical Microbiology, Mayo Clinic, Rochester, MN; Infectious Diseases, Mayo Clinic, Rochester, MN. Electronic address:

Prosthetic joint infection (PJI) is a rare but challenging complication of arthroplasty. Herein, we describe the epidemiology and microbiology of PJI, with a focus on analyzing differences between the microbiology of polymicrobial versus monomicrobial infection of hip, knee, and shoulder prostheses. In addition, we report the most frequent co-pathogens in polymicrobial infections, as detected by culture. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2019.01.006DOI Listing
January 2019
1 Read

[Polyresistent microflora in the structure of microorganisms divided from blood of patients of the general hospital.]

Klin Lab Diagn 2018 ;63(9):574-578

Samara State Medical University, 43099, Samara, Russia.

The aim of our research was to evaluate the structure and the determination of the phenotypes of antibiotic resistance of microflora isolated from patients' blood in a multidisciplinary hospital during the period from 2013 to 2017. The material was taken into BacT / ALERT bottles containing nutrient media, followed by incubation of blood. In case of a positive result, the material from the vials was dispersed into dense nutrient media. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-9-574-578DOI Listing
January 2018

Ingestion of killed bacteria activates antimicrobial peptide genes in Drosophila melanogaster and protects flies from septic infection.

Dev Comp Immunol 2019 Feb 4;95:10-18. Epub 2019 Feb 4.

School of Life Sciences, Central China Normal University, Wuhan, 430079, China; Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Kansas City, MO, 64110, USA. Electronic address:

Drosophila melanogaster possesses a sophisticated and effective immune system composed of humoral and cellular immune responses, and production of antimicrobial peptides (AMPs) is an important defense mechanism. Expression of AMPs is regulated by the Toll and IMD (immune deficiency) pathways. Production of AMPs can be systemic in the fat body or a local event in the midgut and epithelium. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.001DOI Listing
February 2019

Antibiotic ResistanceCan Be Enhanced in Gram-Positive Species by Some Biocidal Agents Used for Disinfection.

Authors:
Günter Kampf

Antibiotics (Basel) 2019 Feb 1;8(1). Epub 2019 Feb 1.

Institute for Hygiene and Environmental Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.

Some biocidal agents used for disinfection have been described to enhance antibiotic resistance in Gram-negative species. The aim of this review was therefore to evaluate the effect of 13 biocidal agents at sublethal concentrations on antibiotic resistance in Gram-positive species. A MEDLINE search was performed for each biocidal agent on antibiotic tolerance, antibiotic resistance, horizontal gene transfer, and efflux pump. Read More

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http://dx.doi.org/10.3390/antibiotics8010013DOI Listing
February 2019
1 Read

Combination Antimicrobial Therapy for Enterococcus faecalis Infective Endocarditis.

Clin Infect Dis 2019 Feb 1. Epub 2019 Feb 1.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz054DOI Listing
February 2019
6 Reads

Evaluation of an overnight non-culture test for detection of viable Gram-negative bacteria in endoscope channels.

Endosc Int Open 2019 Feb 30;7(2):E268-E273. Epub 2019 Jan 30.

St. Boniface Research Centre, Winnipeg, MB, Canada.

 Prevention of infection transmission from contaminated endoscopes would benefit from a rapid test that could detect low levels of viable bacteria after high level disinfection. The aim of this study was to evaluate the rapid NOW! (RN) test's ability to detect endoscope contamination. The RN test kit and the accompanying fluorometer were evaluated. Read More

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http://dx.doi.org/10.1055/a-0808-4342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353648PMC
February 2019

Antibiofilm activity of natural zeolite supported NanoZnO: inhibition of Esp gene expression of Enterococcus faecalis.

Nanomedicine (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Aim: To evaluate the antibiofilm effect and esp gene downregulation of Enterococcus faecalis through nanozinc oxide fabricated on natural zeolite (NanoZnO/Ze). Materials & methods:Zeolite and NanoZnO/Ze materials were characterized by x-ray diffraction, x-ray fluorescence and field emission scanning electron microscopy coupled with energy dispersive x-ray. Atomic absorption spectroscopy was used to evaluate zinc release. Read More

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http://dx.doi.org/10.2217/nnm-2018-0173DOI Listing
January 2019
1 Read

Direct identification of pathogens in urine using a specific MALDI-TOF spectra database.

J Clin Microbiol 2019 Jan 30. Epub 2019 Jan 30.

IHU-Méditerranée Infection, Marseille, France

Urinary tract infections are among the most common reasons for antimicrobial treatment, early diagnosis could have a significant impact by enabling rapid administration of the adapted antibiotic and preventing complications. The current delay between sample receipt and pathogen identification is about 24-48 hours, which could be significantly shortened by an accurate direct method. Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) is already used for the identification of pathogens in clinical laboratories and constitutes a promising tool for direct diagnosis. Read More

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http://dx.doi.org/10.1128/JCM.01678-18DOI Listing
January 2019
1 Read

The Enterococcus: a Model of Adaptability to Its Environment.

Clin Microbiol Rev 2019 Mar 30;32(2). Epub 2019 Jan 30.

Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

SUMMARYThe genus comprises a ubiquitous group of Gram-positive bacteria that are of great relevance to human health for their role as major causative agents of health care-associated infections. The enterococci are resilient and versatile species able to survive under harsh conditions, making them well adapted to the health care environment. Two species cause the majority of enterococcal infections: and Both species demonstrate intrinsic resistance to common antibiotics, such as virtually all cephalosporins, aminoglycosides, clindamycin, and trimethoprim-sulfamethoxazole. Read More

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http://cmr.asm.org/lookup/doi/10.1128/CMR.00058-18
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http://dx.doi.org/10.1128/CMR.00058-18DOI Listing
March 2019
2 Reads

Antimicrobial Resistance and Biofilm Formation in Enterococcus spp. Isolated from Humans and Turkeys in Poland.

Microb Drug Resist 2019 Jan 30. Epub 2019 Jan 30.

1 Department of Epizootiology with Clinic of Birds and Exotic Animals, Wroclaw University of Environmental and Life Sciences, Wrocław, Poland.

Enterococci are a natural component of the intestinal flora of many organisms, including humans and birds. As opportunistic pathogens, they can cause fatal infections of the urinary tract and endocarditis in humans, whereas in poultry symptoms are joint disease, sepsis, and falls in the first week of life. The study covered 107 Enterococcus strains-56 isolated from humans and 51 from turkeys. Read More

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http://dx.doi.org/10.1089/mdr.2018.0221DOI Listing
January 2019
1 Read

Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal.

BMC Pediatr 2019 Jan 29;19(1):36. Epub 2019 Jan 29.

Department of Microbiology and Infectious Diseases, B. P. Koirala Institute of Health Sciences, Dharan, Sunsari, 56700, Nepal.

Background: Urinary tract infection (UTI) is one of most common pediatric infections. The study was designed to assess the clinical profile, common bacterial microorganisms causing UTI and their antimicrobial susceptibility patterns at B. P. Read More

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http://dx.doi.org/10.1186/s12887-019-1410-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350346PMC
January 2019
1 Read

Occurrence of enterococci harbouring clinically important antibiotic resistance genes in the aquatic environment in Gauteng, South Africa.

Environ Pollut 2019 Feb 19;245:1041-1049. Epub 2018 Nov 19.

Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; National Health Laboratory Service, Tshwane Academic Division, Pretoria, South Africa. Electronic address:

The development of antibiotic resistance and dissemination of its determinants is an emerging public health problem as it compromises treatment options of infections that were, until recently, treatable. Investigation of outbreaks of vancomycin resistant enterococci (VRE) suggests that the environment serves as a significant reservoir for antibiotic resistance genes (ARGs). However, there is a paucity of data regarding the presence of ARGs in the water sources in South Africa. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.11.040DOI Listing
February 2019

Hydrophobicity of graphene as a driving force for inhibiting biofilm formation of pathogenic bacteria and fungi.

Dent Mater 2018 Nov 10. Epub 2018 Nov 10.

Faculty of Dentistry, National University of Singapore, Singapore; Centre for Advanced 2D Materials and Graphene Research Centre, National University of Singapore, Singapore. Electronic address:

Objective: To evaluate the surface and wettability characteristics and the microbial biofilm interaction of graphene coating on titanium.

Methods: Graphene was deposited on titanium (Control) via a liquid-free technique. The transfer was performed once (TiGS), repeated two (TiGD) and five times (TiGV) and characterized by AFM (n=10), Raman spectroscopy (n=10), contact angle and SFE (n=5). Read More

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http://dx.doi.org/10.1016/j.dental.2018.09.016DOI Listing
November 2018

PLGA submicron particles containing chlorhexidine, calcium and phosphorus inhibit Enterococcus faecalis infection and improve the microhardness of dentin.

J Mater Sci Mater Med 2019 Jan 22;30(2):17. Epub 2019 Jan 22.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

Enterococcus faecalis (E. faecalis), a Gram-positive facultative anaerobe, is reported to take responsibility for a large portion of refractory root canal infections and root canal re-infections of human teeth. Chlorhexidine is a strong bactericide against E. Read More

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http://dx.doi.org/10.1007/s10856-018-6216-4DOI Listing
January 2019
1 Read

Asymptomatic bacteriuria in recurrent UTI - to treat or not to treat.

GMS Infect Dis 2017 28;5:Doc09. Epub 2017 Dec 28.

Department of Translational Research and New Technologies, University of Pisa, Italy.

Asymptomatic bacteriuria (ABU) is a common clinical condition that often leads to unnecessary antimicrobial use. The reduction of antibiotic overuse for ABU is consequently an important issue for antimicrobial stewardship to reduce the emergence of multidrug resistant strains. In the clinical setting we have an important issue that requires special attention: the role of ABU in women affected by recurrent urinary tract infections (rUTIs). Read More

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http://dx.doi.org/10.3205/id000035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301734PMC
December 2017

[Consumption of antibiotics in a burns intensive care unit].

Handchir Mikrochir Plast Chir 2019 Jan 22. Epub 2019 Jan 22.

Klinikum St. Georg - Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie.

Introduction: Burn-injured patients are at particularly high risk of infection; as such one would expect an increased requirement of antibiotics compared to other intensive care patients. There is no data in the literature investigating this hypothesis in Germany. The aim of this study was to determine the antibiotic consumption in severe burn patients and to compare this data with those from surgical intensive care units. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0739-7820
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http://dx.doi.org/10.1055/a-0739-7820DOI Listing
January 2019
4 Reads

Antimicrobial resistance of Escherichia coli and Enterococcus spp. isolated from Estonian cattle and swine from 2010 to 2015.

Acta Vet Scand 2019 Jan 21;61(1). Epub 2019 Jan 21.

Estonian University of Life Sciences, Kreutzwaldi 62, Tartu, Estonia.

Background: The prevalence of resistant Escherichia coli and Enterococcus spp. in food-producing animals has increased worldwide. The objective of the study was to investigate the occurrence of antimicrobial resistance of Escherichia coli, Enterococcus faecium and Enterococcus faecalis isolated from healthy and diseased swine and cattle in Estonia. Read More

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http://dx.doi.org/10.1186/s13028-019-0441-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341677PMC
January 2019

A core genome multilocus sequence typing (cgMLST) scheme for .

J Clin Microbiol 2019 Jan 16. Epub 2019 Jan 16.

Robert Koch- Institute, Division of Nosocomial Pathogens and Antibiotic Resistances, Wernigerode, Germany.

Among enterococci, occurs ubiquitously, with the highest incidence of human and animal infections. The high genetic plasticity of complicates both molecular investigations and phylogenetic analyses. Whole-genome sequencing (WGS) enables unraveling of epidemiological linkages and putative transmission events between humans, animals, and food. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.01686-18
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http://dx.doi.org/10.1128/JCM.01686-18DOI Listing
January 2019
8 Reads

The Role of Ertapenem for the Treatment of Complicated Intra-abdominal Infections With a Positive Culture for .

Open Forum Infect Dis 2019 Jan 15;6(1):ofy339. Epub 2018 Dec 15.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Controversy remains as to whether recovered from intra-abdominal infections (IAIs) requires targeted therapy. In a multicenter study comparing patients with IAIs from which was identified in intra-abdominal cultures, no difference in clinical outcomes was observed between patients receiving ertapenem vs those receiving piperacillin/tazobactam. Read More

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http://dx.doi.org/10.1093/ofid/ofy339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329900PMC
January 2019

Distribution of acquired antibiotic resistance genes among Enterococcus spp. isolated from a hospital in Baotou, China.

BMC Res Notes 2019 Jan 15;12(1):27. Epub 2019 Jan 15.

The Second Affiliated Hospital, Baotou Medical College, 30 Hude Mulin Street, Baotou, 014030, China.

Objective: This study investigated the distribution of acquired antibiotic resistance genes in Enterococcus species isolated from clinical patients in Baotou, China.

Result: A total of 73 enterococca lisolates from clinical samples were collected from December 2016 to September 2017. Of the 73 enterococcal isolates, 36 (49. Read More

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http://dx.doi.org/10.1186/s13104-019-4064-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334421PMC
January 2019
1 Read

Countermeasures Defeat a Virulent Bacteriophage.

Viruses 2019 Jan 10;11(1). Epub 2019 Jan 10.

Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.

is an opportunistic pathogen that has emerged as a major cause of nosocomial infections worldwide. Many clinical strains are indeed resistant to last resort antibiotics and there is consequently a reawakening of interest in exploiting virulent phages to combat them. However, little is still known about phage receptors and phage resistance mechanisms in enterococci. Read More

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http://www.mdpi.com/1999-4915/11/1/48
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http://dx.doi.org/10.3390/v11010048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356687PMC
January 2019
5 Reads

Matrix metalloprotease-1 inhibits and disrupts Enterococcus faecalis biofilms.

PLoS One 2019 11;14(1):e0210218. Epub 2019 Jan 11.

Department of Physics, Colorado School of Mines, CO, United States of America.

Enterococcus faecalis is a major opportunistic pathogen that readily forms protective biofilms leading to chronic infections. Biofilms protect bacteria from detergent solutions, antimicrobial agents, environmental stress, and effectively make bacteria 10 to 1000-fold more resistant to antibiotic treatment. Extracellular proteins and polysaccharides are primary components of biofilms and play a key role in cell survival, microbial persistence, cellular interaction, and maturation of E. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210218PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329490PMC
January 2019
4 Reads

Age-Specific Cutoffs of the Sysmex UF-1000i Automated Urine Analyzer for Rapid Screening of Urinary Tract Infections in Outpatients.

Ann Lab Med 2019 May;39(3):322-326

Department of Laboratory Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

We investigated the usefulness of age-specific cutoffs for screening of urinary tract infections (UTIs) in Korean outpatients, using the automated urine analyzer UF-1000i (Sysmex, Kobe, Japan). We retrospectively reviewed outpatient medical records. Urine samples of 7,443 outpatients from January 2010 to December 2017 were analyzed using urine culture and UF-1000i. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3343/alm.2019.39
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http://dx.doi.org/10.3343/alm.2019.39.3.322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340846PMC
May 2019
12 Reads

Impact on Public Health of the Spread of High-Level Resistance to Gentamicin and Vancomycin in Enterococci.

Front Microbiol 2018 18;9:3073. Epub 2018 Dec 18.

Hospital Alemán, Buenos Aires, Argentina.

Antibiotic resistance has turned into a global public health issue. Enterococci are intrinsically resistant to many antimicrobials groups. These bacteria colonize dairy and meat products and integrate the autochthonous microbiota of mammal's gastrointestinal tract. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305282PMC
December 2018
5 Reads

Bacterial susceptibility in bloodstream infections: Results from China Antimicrobial Resistance Surveillance Trial (CARST) Program, 2015-2016.

J Glob Antimicrob Resist 2019 Jan 3. Epub 2019 Jan 3.

Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.

Objectives: The aim of this study was to monitor the trends in antimicrobial resistance from the blood samples' isolated from the Chinese mainland.

Methods: All the clinical isolates were collected from 18 hospitals and the minimal inhibitory concentrations (MICs) were tested using agar dilution method recommended by Clinical and Laboratory Standards Institute (CLSI) in central laboratory. The susceptibilities of isolates to antimicrobial agents were determined by using CLSI or European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2017 guideline. Read More

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http://dx.doi.org/10.1016/j.jgar.2018.12.016DOI Listing
January 2019

Antimicrobial activity of intracanal medications against both Enterococcus faecalis and Candida albicans biofilm.

Microsc Res Tech 2018 Dec 29. Epub 2018 Dec 29.

Department of Restorative Dentistry, Dental Materials and Endodontics, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil.

Enterococcus faecalis and Candida albicans have been associated with cases of secondary and persistent root canal infections, been resistant to calcium hydroxide. So, the evaluation of the susceptibility of these microorganisms biofilms to new drugs is an important practice for establishing the best drug and consequently success of treatment. For this, in vitro biofilm formation of E. Read More

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http://doi.wiley.com/10.1002/jemt.23192
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http://dx.doi.org/10.1002/jemt.23192DOI Listing
December 2018
7 Reads

Age-related Trends in Adults with Urinary Tract Infections Presenting to the Emergency Department: A 5-Year Experience.

Rev Recent Clin Trials 2018 Dec 26. Epub 2018 Dec 26.

Emergency Department, Catholic University of Rome, Fondazione Policlinico A. Gemelli. Italy.

Introduction: Urinary tract infections (UTIs) are among the most common bacterial infections, affecting 150 million people worldwide each year. Importantly, the incidence of UTI increases markedly with age. The increasing resistance to empirically prescribed antimicrobial agents complicates the management of this disease. Read More

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http://dx.doi.org/10.2174/1574887114666181226161338DOI Listing
December 2018
1 Read

Influence of Gas Temperature in Atmospheric Non-Equilibrium Plasma on Bactericidal Effect.

Biocontrol Sci 2018 ;23(4):167-175

FIRST, Tokyo Institute of Technology.

In this study, the relationship between plasma gas temperature and the bactericidal effects on five of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis and Bacillus cereus (spore)) in liquid was investigated using a temperature-controllable plasma source. We determined that the bactericidal ability improved as the plasma gas temperature increased. Specifically, the bactericidal ability on E. Read More

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http://dx.doi.org/10.4265/bio.23.167DOI Listing
January 2018

LiaR-independent pathways to daptomycin resistance in Enterococcus faecalis reveal a multilayer defense against cell envelope antibiotics.

Mol Microbiol 2018 Dec 24. Epub 2018 Dec 24.

Center for Antimicrobial Resistance and Microbial Genomics, University of Texas Health Science Center, McGovern School of Medicine, Houston, TX, USA.

The lipopeptide antibiotic daptomycin (DAP) is a key drug against serious enterococcal infections, but the emergence of resistance in the clinical setting is a major concern. The LiaFSR system plays a prominent role in the development of DAP resistance (DAP-R) in enterococci, and blocking this stress response system has been proposed as a novel therapeutic strategy. In this work, we identify LiaR-independent pathways in Enterococcus faecalis that regulate cell membrane adaptation in response to antibiotics. Read More

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http://dx.doi.org/10.1111/mmi.14193DOI Listing
December 2018
1 Read

Synergistic and antagonistic effects of Citrus bergamia distilled extract and its major components on drug resistant clinical isolates.

Nat Prod Res 2018 Dec 22:1-4. Epub 2018 Dec 22.

a Department of Health Sciences , Institute of Microbiology, University "Magna Graecia" of Catanzaro , Italy.

In this study we determine the in vitro antimicrobial activities of Citrus bergamia distilled extract and compounds isolated from such extract against clinical MDR strains. The activity of these substances were tested using a broth microdilution assay, their MBC and their FBC to evaluate the nature of the interactions in tested components. Among Gram negative bacteria Enterobacter spp, Klebsiella spp and Pseudomonas spp exhibited the higher MBC values range (2. Read More

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http://dx.doi.org/10.1080/14786419.2018.1522631DOI Listing
December 2018

Distribution of Late-Onset Neonatal Sepsis Pathogens Differs in Inpatient and Outpatient Settings.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, New York University School of Medicine, New York, New York.

Objective:  We sought to examine pathogen distribution and clinical presentation of late-onset sepsis (LOS) at an urban tertiary care center.

Study Design:  We performed a retrospective review of all culture-confirmed cases of LOS presenting to our institution from 2013 to 2017. Medical records were evaluated for demographic information, sepsis risk factors, encounter location, and clinical outcome. Read More

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http://dx.doi.org/10.1055/s-0038-1675643DOI Listing
December 2018
2 Reads

Emergence of High-level Gentamicin Resistance among Clinical Isolates from Burn Patients in South-west of Iran: Vancomycin Still Working.

Pol J Microbiol 2018 ;67(4):401-406

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Enterococcus faecalis and Enterococcus faecium are among the main agents associated with nosocomial infections with high mortality in immunocompromised patients. Antibiotic resistance, especially against gentamicin and vancomycin among Enterococci , is a risk factor that could increase the morbidity and mortality rate. 179 Enterococci isolates from burn patients were included in this study. Read More

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http://dx.doi.org/10.21307/pjm-2018-043DOI Listing
January 2018

Prevalence and antimicrobial susceptibility of bacterial pathogens isolated from urine specimens received in rizgary hospital - Erbil.

J Infect Public Health 2018 Dec 3. Epub 2018 Dec 3.

Laboratory Department, Rizgary Teaching Hospital, Erbil, Kurdistan Region, Iraq.

Background: Urinary tract infection (UTI) is a common health-associated problem worldwide. Like other medical conditions, UTI patients may suffer from poor treatment outcomes due to the emergence of antimicrobial resistance. Determining patterns of antimicrobial susceptibility in uropathogens will guide physicians to choose the best antibiotics for treating affected patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341183031
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http://dx.doi.org/10.1016/j.jiph.2018.11.005DOI Listing
December 2018
2 Reads

High-Temperature Short-Time Treatment of Human Milk for Bacterial Count Reduction.

Front Pediatr 2018 27;6:359. Epub 2018 Nov 27.

Center for Pediatrics, Department of Neonatology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

Human milk (HM) for preterm infants will often be pasteurized for cytomegalovirus (CMV) inactivation and reduction of its bacterial count. High-temperature short-time (HTST) treatment compared to standard Holder pasteurization (HoP) reduces the impact of heat treatment on bioactive HM proteins while effectively inactivating CMV. No data are available for the efficacy of bacterial count reduction using HTST treatments that are available for clinical use. Read More

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http://dx.doi.org/10.3389/fped.2018.00359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277678PMC
November 2018
11 Reads

Epidemiological characteristics and genetic structure of linezolid-resistant .

Infect Drug Resist 2018 20;11:2397-2409. Epub 2018 Nov 20.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China,

Objectives: The aim of this study was to investigate the mechanism of linezolid resistance and evaluate the risk factors for linezolid-resistant (LZR-Efa) infections.

Methods: A total of 730 isolates were collected, and whole-genome sequencing and bioinformatics analysis were performed. Meanwhile, risk factors related to linezolid resistance were analyzed by binary logistic regression. Read More

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https://www.dovepress.com/epidemiological-characteristics-an
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http://dx.doi.org/10.2147/IDR.S181339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251436PMC
November 2018
9 Reads

[Clinical and microbiological aspects of peritonitis associated with peritoneal dialysis in adult patients with chronic renal failure in the Emergency Department].

Rev Chilena Infectol 2018 ;35(3):225-232

Escuela Superior de Medicina, Instituto Politécnico Nacional, Instituto Mexicano del Seguro Social, México, D.F, México.

Background: Peritonitis is the most important and frequent complication of peritoneal dialysis (PD). Bacterial infections are responsible in most cases, with characteristic symptoms.

Aim: To determine the most frequent pathogens in peritonitis associated with PD in patients with chronic renal failure (CRF). Read More

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http://dx.doi.org/10.4067/s0716-10182018000300225DOI Listing
January 2018
1 Read

Antimicrobial assay of combination surfactant irrigant regimen on vancomycin-resistant . An direct contact test.

Dent Res J (Isfahan) 2018 Nov-Dec;15(6):397-403

Department of Biochemistry, ABSMIDS, NITTE University, Mangaluru, Karnataka, India.

Background: Vancomycin-resistant enterococci (VRE) are on the rise globally in primary intraradicular infections and resistant to most intracanal irrigants and medicaments. The aim of this study was to evaluate the efficacy of irrigants and identify a cost-effective regimen to eradicate VRE.

Materials And Methods: In this study irrigants were categorized as primary and surfactant groups with individual concentrations consisting of 10 samples each. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243805PMC
December 2018
2 Reads

Prevalence of vancomycin resistance among isolates of enterococci in Iran: a systematic review and meta-analysis.

Adolesc Health Med Ther 2018 15;9:177-188. Epub 2018 Nov 15.

School of Medicine, Ilam University of Medical Sciences, Ilam, Iran,

Introduction: is responsible for 10% of hospital-acquired infections. The purpose of this review was to evaluate the prevalence of vancomycin-resistant (VRE) isolates in Iran using a meta-analysis method.

Materials And Methods: Iranian databases, including Magiran and IranDoc, and international databases, including PubMed and MedLib, were examined carefully, and a total of 20 articles published between 2000 and 2011 were extracted. Read More

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http://dx.doi.org/10.2147/AHMT.S180489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241717PMC
November 2018
7 Reads

A multicenter epidemiology study on the risk factors and clinical outcomes of nosocomial intra-abdominal infections in China: results from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) 2007-2016.

Infect Drug Resist 2018 15;11:2311-2319. Epub 2018 Nov 15.

Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China,

Objective: This study aimed to determine the risk factors for intra-abdominal infections (IAIs), assess the clinical outcomes of IAIs, and investigate the spectrum and antimicrobial resistance of major pathogens causing IAIs.

Patients And Methods: This prospective observational study enrolled patients from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) program between 2007 and 2016. Data on the clinicopathological factors and causative pathogens were collected. Read More

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https://www.dovepress.com/a-multicenter-epidemiology-study-o
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http://dx.doi.org/10.2147/IDR.S182180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245374PMC
November 2018
3 Reads

Molecular detection of and genes among vancomycin-resistant enterococci in ICU-hospitalized patients in Ahvaz in southwest of Iran.

Infect Drug Resist 2018 15;11:2269-2275. Epub 2018 Nov 15.

School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Nosocomial infections due to vancomycin-resistant enterococci (VRE) are known as a source of spreading these bacteria. The aim of this prospective study was molecular detection of and genes among VRE isolated from patients admitted to intensive care units (ICUs) in Ahvaz in southwest of Iran.

Materials And Methods: Overall, 243 non-duplicate rectal swab specimens were collected from ICU-hospitalized patients in teaching hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences, Iran. Read More

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http://dx.doi.org/10.2147/IDR.S177886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245376PMC
November 2018

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics.

Biomaterials 2019 Feb 21;192:551-559. Epub 2018 Nov 21.

Department of Nanobiomedicine/ENT, University Medical Center of Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany. Electronic address:

Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice, including wound dressings and implants. We report that nanoparticles' bactericidal activity strongly depends on their physical binding to pathogens, including multidrug-resistant primary clinical isolates, such as Staphylococcus aureus, Klebsiella pneumoniae or Enterococcus faecalis. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2018.11.028DOI Listing
February 2019
6 Reads

Intracellular Accumulation of Linezolid and Florfenicol in OptrA-Producing and .

Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

The gene, which confers transferable resistance to oxazolidinones and phenicols, is defined as an ATP-binding cassette (ABC) transporter but lacks transmembrane domains. The resistance mechanism of and whether it involves antibiotic efflux or ribosomal protection remain unclear. In this study, we determined the MIC values of all bacterial strains by broth microdilution, and used ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry to quantitatively determine the intracellular concentrations of linezolid and florfenicol in and . Read More

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http://www.mdpi.com/1420-3049/23/12/3195
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http://dx.doi.org/10.3390/molecules23123195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320770PMC
December 2018
12 Reads

Evaluation of chemokines and receptors in gnotobiotic root canal infection by F. nucleatum and E. faecalis.

Braz Oral Res 2018 Nov 29;32:e120. Epub 2018 Nov 29.

Universidade Federal de Minas Gerais - UFMG, Faculty of Dentistry, Department of Restorative Dentistry, Belo Horizonte, MG, Brazil.

The present study aims to evaluate the longitudinal effects of induced experimental infections in gnotoxenic animals on the expression of inflammatory chemokines and their receptors in periradicular tissues. The null hypothesis tested was that Enterococcus faecalis and Fusobacterium nucleatum had no effect on CCR5, CCL5, CXCL10, CCL2/MCP-1, CXCR2 and CCR1 expression. Two groups of five animals (n = 5) aged between 8 and 12 weeks were used in this study. Read More

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http://dx.doi.org/10.1590/1807-3107bor-2018.vol32.0120DOI Listing
November 2018
2 Reads