7,012 results match your criteria Streptococcus Group B Infections


Clinical characteristics of patients with severe sepsis and septic shock in relation to bacterial virulence of beta-hemolytic and .

Acute Med Surg 2020 Jan-Dec;7(1):e513. Epub 2020 May 31.

Division of Acute and Critical Care Medicine Hokkaido University Graduate School of Medicine Sapporo Japan.

Aim: Combined detailed analysis of patient characteristics and treatment as well as bacterial virulence factors, which all play a central role in the cause of infections leading to severe illness, has not been reported. We aimed to describe the patient characteristics (Charlson comorbidity index [CCI]), treatment (3-h bundle), and outcomes in relation to bacterial virulence of and beta-hemolytic (BHS).

Methods: This sepsis primary study is part of the larger Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) study, a multicenter, prospective cohort study. Read More

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http://dx.doi.org/10.1002/ams2.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262430PMC

Meningitis and bacteremia by nonhemolytic Group B Streptococcus strain: a whole genome analysis.

Microbiol Immunol 2020 Jun 2. Epub 2020 Jun 2.

Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamiokimachi, Maebashi, Gunma, Japan.

Group B streptococcus (GBS) is a leading cause of neonatal infections. Most isolates are β-hemolytic, and their activity is considered to be pivotal for GBS pathogenicity. We report a case of a neonate with meningitis caused by nonhemolytic GBS. Read More

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http://dx.doi.org/10.1111/1348-0421.12826DOI Listing

A simple, rapid typing method for Streptococcus agalactiae based on ribosomal subunit proteins by MALDI-TOF MS.

Sci Rep 2020 May 29;10(1):8788. Epub 2020 May 29.

Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong.

Streptococcus agalactiae (Group B Streptococcus, GBS), is a frequent human colonizer and a leading cause of neonatal meningitis as well as an emerging pathogen in non-pregnant adults. GBS possesses a broad animal host spectrum, and recent studies proved atypical GBS genotypes can cause human invasive diseases through animal sources as food-borne zoonotic infections. We applied a MALDI-TOF MS typing method, based on molecular weight variations of predefined 28 ribosomal subunit proteins (rsp) to classify GBS strains of varying serotypes into major phylogenetic lineages. Read More

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http://dx.doi.org/10.1038/s41598-020-65707-5DOI Listing

Assessment of a Multiplex Serological Test for the Diagnosis of Prosthetic Joint Infection: a Prospective Multicentre Study.

J Bone Jt Infect 2020 30;5(2):89-95. Epub 2020 Mar 30.

Bacteriology Department, CHU Nantes, Nantes Université, Nantes, France.

The diagnosis of prosthetic joint infections (PJIs) can be difficult in the chronic stage and is based on clinical and paraclinical evidence. A minimally invasive serological test against the main pathogens encountered during PJI would distinguish PJI from mechanical loosening. We performed a prospective, multicentre, cross-sectional study to assess the contribution of serology in the diagnosis of PJI. Read More

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http://dx.doi.org/10.7150/jbji.42076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242409PMC

Invasive Group B Streptococcus Infections in Adults, England, 2015-2016.

Emerg Infect Dis 2020 Jun;26(6):1174-1181

During 2015-2016, a total of 3,156 episodes of invasive group B Streptococcus (iGBS) infection in adults (>15 years of age) were recorded in England, corresponding to an annual incidence of 3.48/100,000 population. iGBS incidence was highest in older patients and women of childbearing age. Read More

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http://dx.doi.org/10.3201/eid2606.191141DOI Listing

whISOBAX Inhibits Bacterial Pathogenesis and Enhances the Effect of Antibiotics.

Antibiotics (Basel) 2020 May 19;9(5). Epub 2020 May 19.

Department of Chemistry and Food Science, Framingham State University, Framingham, MA 01701, USA.

As bacteria are becoming more resistant to commonly used antibiotics, alternative therapies are being sought. whISOBAX (WH) is a witch hazel extract that is highly stable (tested up to 2 months in 37 °C) and contains a high phenolic content, where 75% of it is hamamelitannin and traces of gallic acid. Phenolic compounds like gallic acid are known to inhibit bacterial growth, while hamamelitannin is known to inhibit staphylococcal pathogenesis (biofilm formation and toxin production). Read More

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http://dx.doi.org/10.3390/antibiotics9050264DOI Listing

The Negative Predictive Ability of Immature Neutrophils for Bacteremia in Children With Community-Acquired Infections.

Front Pediatr 2020 6;8:208. Epub 2020 May 6.

Post-graduation Program in Health Sciences, Federal University of Bahia School of Medicine, Salvador, Brazil.

Bacteremia is a serious condition. We aimed to assess the role of immature neutrophils in peripheral blood smears for prediction of bacteremia in children. In this cross-sectional study conducted in Salvador, Brazil, blood cultures collected from patients aged ≤18 years were identified. Read More

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http://dx.doi.org/10.3389/fped.2020.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218047PMC

Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.

Pathogens 2020 May 15;9(5). Epub 2020 May 15.

Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, Naumburger Str. 96a, 07743 Jena, Germany.

The aim of this study was to characterize staphylococci and streptococci in milk from Egyptian bovides. In total, 50 milk samples were collected from localities in the Nile Delta region of Egypt. Isolates were cultivated, identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), and antibiotic susceptibility testing was performed by the broth microdilution method. Read More

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http://dx.doi.org/10.3390/pathogens9050381DOI Listing

Repetitive cellulitis caused by isolates with different genotypic and phenotypic features in a patient having upper extremity with lymphedema after mastectomy and axillary lymph node dissection.

IDCases 2020 6;20:e00793. Epub 2020 May 6.

Laboratory of Infectious Diseases, Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Previously reported cases of recurrent cellulitis/erysipelas affecting chronically lymphedematous skin regions have been demonstrated to be due to isolates with closely related genetic background which may be suggestive of relapse rather than reinfection. Herein, we report the occurrence of three episodes of repetitive cellulitis caused by strains with different genotypic and phenotypic characteristics, including different antimicrobial susceptibility patterns (tetracycline, macrolide/lincosamide, and fluoroquinolone classes), in the left upper extremity of a patient with lymphedema, following left mastectomy and axillary lymph node dissection. The genotypic and phenotypic characteristics of the three isolates were confirmed based on the random amplified polymorphic DNA patterns, DNA profiles of virulence factors (----), data on biofilm formation and cell invasion, antimicrobial susceptibility testing results, antimicrobial resistance (AMR) genotypes, and amino acid mutations associated with AMR. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218289PMC

Antibiotic Resistance and Molecular Epidemiological Characteristics of Isolated from Pregnant Women in Guangzhou, South China.

Can J Infect Dis Med Microbiol 2020 30;2020:1368942. Epub 2020 Apr 30.

The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

colonization in pregnant women can cause postpartum intrauterine infections and life-threatening neonatal infections. To formulate strategies for the prevention and treatment of infections, we performed a comprehensive analysis of antibiotic resistance and a molecular-based epidemiological investigation of in this study. Seventy-two strains, collected from pregnant women, were subjected to antibiotic susceptibility tests; then, the screened erythromycin and clindamycin nonsusceptible isolates were used for macrolides and clindamycin resistance genes detection, respectively. Read More

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http://dx.doi.org/10.1155/2020/1368942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210523PMC

Ampicillin Treatment Increases Placental Interleukin-1 Beta Concentration and Polymorphonuclear Infiltration in Group B Streptococcus-Induced Chorioamnionitis: A Preclinical Study.

Neonatology 2020 May 6:1-5. Epub 2020 May 6.

Child Neurology Division, Department of Pediatrics, McGill University, Montreal, Québec, Canada.

Background: Antibiotic therapy during preterm labor with intact membranes has been associated with an increased risk of neonatal death.

Objectives: Using an established rat model of group B Streptococcus (GBS)-induced chorioamnionitis, we hypothesized that ampicillin treatment increases placental inflammation, as shown in other bacterial infections.

Methods: At gestational day 19, 19 Lewis dams were intraperitoneally (i. Read More

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http://dx.doi.org/10.1159/000506906DOI Listing

Urinary Tract Infections among Indonesian Pregnant Women and Its Susceptibility Pattern.

Infect Dis Obstet Gynecol 2020 21;2020:9681632. Epub 2020 Apr 21.

Faculty of Medicine Universitas Indonesia, Indonesia.

Pregnant women are usually at risk of urinary tract infections (UTIs) such as asymptomatic bacteriuria. In the current multidrug-resistance era, appropriate diagnosis and treatment should be provided to avoid complications in pregnant women in developing countries, which have limited facilities, such as Indonesia. The aim of this study was to evaluate in vitro susceptibility tests. Read More

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http://dx.doi.org/10.1155/2020/9681632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191430PMC

A prospective study of bloodstream infections among febrile adolescents and adults attending Yangon General Hospital, Yangon, Myanmar.

PLoS Negl Trop Dis 2020 Apr 30;14(4):e0008268. Epub 2020 Apr 30.

Centre for International Health, University of Otago, Dunedin, New Zealand.

Data on causes of community-onset bloodstream infection in Myanmar are scarce. We aimed to identify etiological agents of bloodstream infections and patterns of antimicrobial resistance among febrile adolescents and adults attending Yangon General Hospital (YGH), Yangon, Myanmar. We recruited patients ≥12 years old with fever ≥38°C who attended YGH from 5 October 2015 through 4 October 2016. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217485PMC

Population-based bloodstream infection surveillance in rural Thailand, 2007-2014.

BMC Public Health 2019 May 10;19(Suppl 3):521. Epub 2019 May 10.

Global Disease Detection Center, Thailand Ministry of Public Health (MOPH) - United States Centers for Disease Control and Prevention (CDC) Collaboration, Nonthaburi, Thailand.

Background: Bloodstream infection (BSI) surveillance is essential to characterize the public health threat of bacteremia. We summarize BSI epidemiology in rural Thailand over an eight year period.

Methods: Population-based surveillance captured clinically indicated blood cultures and associated antimicrobial susceptibility results performed in all 20 hospitals in Nakhon Phanom (NP) and Sa Kaeo (SK) provinces. Read More

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http://dx.doi.org/10.1186/s12889-019-6775-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696817PMC

Prevalence, antimicrobial susceptibility patterns, serotypes and risk factors for group B streptococcus rectovaginal isolates among pregnant women at Kenyatta National Hospital, Kenya; a cross-sectional study.

BMC Infect Dis 2020 Apr 22;20(1):302. Epub 2020 Apr 22.

Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya.

Background: Estimates of Group B Streptococcus (GBS) disease burden, antimicrobial susceptibility, and serotypes in pregnant women are limited for many resource-limited countries including Kenya. These data are required to inform recommendations for prophylaxis and treatment of infections due to GBS.

Methods: We evaluated the prevalence, antimicrobial susceptibility patterns, serotypes, and risk factors associated with rectovaginal GBS colonization among pregnant women receiving antenatal care at Kenyatta National Hospital (KNH) between August and November 2017. Read More

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http://dx.doi.org/10.1186/s12879-020-05035-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178604PMC

Paradoxical Antibiotic Effect of Ampicillin: Use of a Population Pharmacokinetic Model to Evaluate a Clinical Correlate of the Eagle Effect in Infants With Bacteremia.

Pediatr Infect Dis J 2020 Mar 30. Epub 2020 Mar 30.

Department of Pediatrics, Duke University, Durham, North Carolina.

Background: High doses of ampicillin are often used to achieve therapeutic drug concentrations in infants. A paradoxical antibiotic effect, often called the Eagle effect, occurs when increasing concentrations of antibiotic above a threshold results in decreased efficacy. It is unknown if infants treated with ampicillin are at risk for this paradoxical effect. Read More

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http://dx.doi.org/10.1097/INF.0000000000002663DOI Listing

Endogenous endophthalmitis caused by group B streptococcus; case reports and review of 35 reported cases.

BMC Ophthalmol 2020 Mar 31;20(1):126. Epub 2020 Mar 31.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE). However, the number of invasive GBS infections is increasing, particularly in elderly patients with underlying conditions such as diabetes mellitus (DM), cardiovascular disease and cancer. We report 6 cases of EBE caused by GBS and review the literature. Read More

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http://dx.doi.org/10.1186/s12886-020-01378-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110777PMC

The Epidemiology of Invasive Group B in Denmark From 2005 to 2018.

Front Public Health 2020 10;8:40. Epub 2020 Mar 10.

Neisseria and Streptococcus Reference Laboratory, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.

Previous epidemiology reports on invasive (GBS) infections in Denmark did not include all patient age groups. The aim of this study was therefore to analyze the GBS incidence in all age groups during the period 2005-2018 and to present the serotype distribution and the antibiotic susceptibility. Data were retrieved from the Danish laboratory surveillance system, and these included data on typing and susceptibility testing for erythromycin and clindamycin. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076979PMC

Expression and functional analysis of Nile tilapia transferrin receptors (TfRs) in host resistance to pathogenic bacteria and iron ion metabolism.

Fish Shellfish Immunol 2020 May 18;100:407-417. Epub 2020 Mar 18.

Institute of Modern Aquaculture Science and Engineering, School of Life Sciences, South China Normal University, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Guangdong Provincial Engineering Technology Research Center for Environmentally-Friendly Aquaculture, Guangzhou, 510631, PR China. Electronic address:

Transferrin receptors (TfRs) play an essential role in iron-withholding strategy, and are involved in immune response against bacterial infection. In this study, the transferrin receptor 1 (OnTfR1) and transferrin receptor 2 (OnTfR2) genes are identified and characterized in Nile tilapia (Oreochromis niloticus). The open reading frames of OnTfR1 and OnTfR2 are 2220 and 2343 bp of nucleotide sequence, encoding 739 and 780 amino acids, respectively. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.03.027DOI Listing

Involvement of lipid microdomains in human endothelial cells infected by Streptococcus agalactiae type III belonging to the hypervirulent ST-17.

Mem Inst Oswaldo Cruz 2020 16;115:e190398. Epub 2020 Mar 16.

Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcântara Gomes, Laboratório de Biologia Molecular e Fisiologia de Estreptococos, Rio de Janeiro, RJ, Brasil.

Background: Streptococcus agalactiae capsular type III strains are a leading cause of invasive neonatal infections. Many pathogens have developed mechanisms to escape from host defense response using the host membrane microdomain machinery. Lipid rafts play an important role in a variety of cellular functions and the benefit provided by interaction with lipid rafts can vary from one pathogen to another. Read More

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http://dx.doi.org/10.1590/0074-02760190398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066991PMC

Subclinical mastitis in pastoralist dairy camel herds in Isiolo, Kenya: Prevalence, risk factors, and antimicrobial susceptibility.

J Dairy Sci 2020 May 12;103(5):4717-4731. Epub 2020 Mar 12.

Department of Disease Control and Epidemiology, National Veterinary Institute, SE-75189, Uppsala, Sweden.

Mastitis is an important constraint to milk production in pastoralist camel (Camelus dromedarius) herds in Kenya. The objective of this study was to investigate the prevalence, risk factors, and bacterial panorama of subclinical mastitis (SCM) in pastoralist camel herds in Isiolo County, Kenya. Furthermore, antimicrobial susceptibility in udder pathogens was studied. Read More

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http://dx.doi.org/10.3168/jds.2019-17701DOI Listing

Intracranial hemorrhage associated with late-onset group B disease-a case report and a review of literature.

Transl Pediatr 2020 Feb;9(1):61-65

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

To report a case of intracranial hemorrhage in an 86-day-old boy with late-onset group B (GBS) disease and review the literature of GBS disease. Physical and auxiliary examinations and PubMed search with keywords of "GBS disease" and "intracranial hemorrhage". The 86-day-old boy was admitted to hospital for respiratory arrest. Read More

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http://dx.doi.org/10.21037/tp.2020.01.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036639PMC
February 2020

Worldwide surveillance of Iclaprim activity: In Vitro susceptibility of gram-positive pathogens collected from patients with skin and skin structure infections from 2013 to 2017.

Diagn Microbiol Infect Dis 2020 May 5;97(1):115013. Epub 2020 Feb 5.

IHMA, Monthey, Switzerland.

Iclaprim is a novel diaminopyrimidine, which inhibits bacterial dihydrofolate reductase, and it is active against Gram-positive pathogens including emerging drug-resistant pathogens. In vitro activity of iclaprim and comparators against 1365 Gram-positive clinical isolates from patients with skin and skin structure infections (SSSI) from the United States, Asia Pacific, Latin America, Europe, Africa or Middle East collected between 2013 and 2017 were tested. Susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.115013DOI Listing

Streptococcus agalactiae infections and clinical relevance in adults, Thailand.

Diagn Microbiol Infect Dis 2020 May 30;97(1):115005. Epub 2020 Jan 30.

Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, Thailand. Electronic address:

Streptococcus agalactiae is an important pathogen that causes infections in neonates and adults; infections especially in nonpregnant adults are increasing worldwide. Of 1736 S. agalactiae isolates from individuals throughout Thailand, serotypes III (46. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.115005DOI Listing

[Evaluation of Microscopic Examination, Culture and Polymerase Chain Reaction Tests in the Diagnosis of Trichomonas vaginalis Infection].

Mikrobiyol Bul 2020 Jan;54(1):135-143

Akdeniz University Faculty of Medicine, Department of Medical Microbiology, Antalya, Turkey.

Sexually transmitted infections (STIs) are important as a public health problem all over the world. There are some difficulties in prevention and control programs of STIs due to clinical and laboratory diagnostic problems.The most common STIs are Chlamydia trachomatis infections, trichomoniasis and gonorrhea. Read More

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http://dx.doi.org/10.5578/mb.68828DOI Listing
January 2020

Recombinant of the Staphylococcal Bacteriophage Lysin CHAP and Its Elimination against Biofilms.

Microorganisms 2020 Feb 6;8(2). Epub 2020 Feb 6.

Gene Engineering Labotory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

Bovine mastitis is the most important infectious disease, causing significant losses in the dairy industry, in which is a major pathogen. In this study, lysin CHAP, derived from bacteriophage K, was expressed heterogeneously, and its antimicrobial and anti-biofilm effects against isolated from bovine mastitis were further analyzed. CHAP was expressed in BL21 (DE3), in which the purified yield of CHAP was up to 14. Read More

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http://dx.doi.org/10.3390/microorganisms8020216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074704PMC
February 2020

Argentinian multicenter study on urinary tract infections due to Streptococcus agalactiae in adult patients.

J Infect Dev Ctries 2019 01 31;13(1):77-82. Epub 2019 Jan 31.

Departamento de Microbiología, Inmunología, Biotecnología y Genética. Cátedra de Microbiología. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: Streptococcus agalactiae (group B streptococcus, GBS) is a recognized urinary pathogen both in males and pregnant or non-pregnant women. Data regarding GBS serotypes recovered from urinary tract infections (UTIs) are scarce. The aim of this study was to describe the clinical and microbiological characteristics of UTIs caused by GBS in adult patients in Argentina. Read More

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http://dx.doi.org/10.3855/jidc.10503DOI Listing
January 2019

[Streptococcus agalactiae infective endocarditis].

Rev Med Liege 2020 Feb;75(2):94-99

Service de Cardiologie, CHU Liège, Belgique.

Infectious endocarditis is a rare pathology whose mortality is high and whose diagnosis is still difficult by the usual clinical, biological and ultrasound tools. We report the case of a patient, drug addict, suffering from an infectious endocarditis of the aortic valve at Streptococcus agalactiae. This germ is rarely at the origin of cardiac infection but it is responsible for quickly destructive lesion by its pathophysiological mechanisms. Read More

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February 2020

IDENTIFICATION AND ANTIBIOTIC SUSCEPTIBILITY PATTERNS OF STREPTOCOCCUS AGALACTIAE.

Georgian Med News 2019 Dec(297):149-153

1G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia.

GBS-Group B streptococcus or Streptococcus agalactiae is a Gram-positive coccus found in 20% of healthy women as part of normal gastrointestinal and genital tract flora. It is associated with pathogenicity in immunocompromised, elderly and pregnant adults as well as infants and neonates. GBS are encapsulated organisms and sub divided into ten antigenically distinct capsular serotypes. Read More

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December 2019

Group B vaginal colonisation in pregnant women at a tertiary care hospital in Mumbai.

Indian J Med Microbiol 2019 Jul-Sep;37(3):446-447

Department of Microbiology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/ijmm.IJMM_19_448DOI Listing

Whole-Genome Sequencing Confirms the Coexistence of Different Colonizing Group B Isolates Underscored by CRISPR Typing.

Microbiol Resour Announc 2020 Jan 30;9(5). Epub 2020 Jan 30.

Université de Tours, INRAE, ISP, Tours, France

is a major pathogen and is the leading cause of neonatal infections in industrialized countries. The diversity of strains isolated from two pregnant women was investigated. Here, we present the draft genome sequences of strains W8A2, W8A6, W10E2, and W10F3, obtained in order to ascertain their phylogenetic affiliation. Read More

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http://dx.doi.org/10.1128/MRA.01359-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992867PMC
January 2020

The Fungal Pathogen Promotes Bladder Colonization of Group B .

Front Cell Infect Microbiol 2019 10;9:437. Epub 2020 Jan 10.

Collaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego, La Jolla, CA, United States.

Group B (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly. However, the factors that govern GBS persistence and disease severity in this niche are not fully understood. Here, we report that the presence of the fungus , a common urogenital colonizer, can promote GBS UTI. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966239PMC
January 2020

Clinical Performance of the Novel GenMark Dx ePlex Blood Culture ID Gram-Positive Panel.

J Clin Microbiol 2020 Mar 25;58(4). Epub 2020 Mar 25.

Medical University of South Carolina, Charleston, South Carolina, USA.

Rapid identification from positive blood cultures is standard of care (SOC) in many clinical microbiology laboratories. The GenMark Dx ePlex Blood Culture Identification Gram-Positive (BCID-GP) Panel is a multiplex nucleic acid amplification assay based on competitive DNA hybridization and electrochemical detection using eSensor technology. This multicenter study compared the investigational-use-only (IUO) BCID-GP Panel to other methods of identification of 20 Gram-positive bacteria, four antimicrobial resistance genes, and both Pan and Pan Gram-Negative targets that are unique to the BCID-GP Panel. Read More

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http://dx.doi.org/10.1128/JCM.01730-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098771PMC

PCR for the detection of pathogens in neonatal early onset sepsis.

PLoS One 2020 24;15(1):e0226817. Epub 2020 Jan 24.

Microbiology, Virology and Infection Control, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.

Background: A large proportion of neonates are treated for presumed bacterial sepsis with broad spectrum antibiotics even though their blood cultures subsequently show no growth. This study aimed to investigate PCR-based methods to identify pathogens not detected by conventional culture.

Methods: Whole blood samples of 208 neonates with suspected early onset sepsis were tested using a panel of multiplexed bacterial PCRs targeting Streptococcus pneumoniae, Streptococcus agalactiae (GBS), Staphylococcus aureus, Streptococcus pyogenes (GAS), Enterobacteriaceae, Enterococcus faecalis, Enterococcus faecium, Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium, a 16S rRNA gene broad-range PCR and a multiplexed PCR for Candida spp. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980546PMC

Contribution of the Uriselect4 and the CPS ID3 chromogenic media to the isolation and identification of urinary tract infections bacteria.

Ann Biol Clin (Paris) 2020 Feb;78(1):47-53

Laboratoire de biologie clinique, Institut National « Zouheir Kallel » de nutrition et de technologie alimentaire, Tunis, Tunisie, Faculté de pharmacie, Université de Monastir, Monastir, Tunisie.

Rapid and accurate identification of pathogens involved in urinary tract infections helps to guide antimicrobial therapy. Chromogenic agars provide presumptive identification directly from primary isolation media. They have been intended to make the bacterial isolation and identification process easier and faster. Read More

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http://dx.doi.org/10.1684/abc.2019.1512DOI Listing
February 2020

Comparative genomic analysis and identification of pathogenicity islands of hypervirulent ST-17 Streptococcus agalactiae Brazilian strain.

Infect Genet Evol 2020 Jun 15;80:104195. Epub 2020 Jan 15.

Laboratory of Molecular Biology and Physiology of Streptococci, Institute of Biology Roberto Alcantara Gomes, Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil. Electronic address:

Streptococcus agalactiae are important pathogenic bacteria that cause severe infections in humans, especially neonates. The mechanism by which ST-17 causes invasive infections than other STs is not well understood. In this study, we sequenced the first genome of a S. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104195DOI Listing
June 2020
3.015 Impact Factor

Comparative study of Revogene GBS LB assay and GeneXpert GBS LB assay for the detection of group B Streptococcus in prenatal screening samples.

BMC Infect Dis 2020 Jan 14;20(1):38. Epub 2020 Jan 14.

Dept. Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, 3170 MFCB, 1685 Highland Ave, Madison, WI, 53705, USA.

Background: Group B Streptococcal (GBS) infections in the United States are a leading cause of meningitis and sepsis in newborns. The CDC therefore recommends GBS screening for all pregnant women at 35-37 weeks of gestation and administration of intrapartum prophylaxis (in those that tested positive) as an effective means of controlling disease transmission. Several FDA approved molecular diagnostic tests are available for rapid and accurate detection of GBS in antepartum women. Read More

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http://dx.doi.org/10.1186/s12879-019-4756-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958782PMC
January 2020

Molecular characterization of Streptococcus agalactiae isolated from pregnant women and newborns at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

BMC Infect Dis 2020 Jan 13;20(1):35. Epub 2020 Jan 13.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.

Background: Streptococcus agalctiae (Group B Streptococcus, GBS) is a perinatal pathogen and a leading cause of neonatal infections worldwide. Serotype, sequence type, clonality, antibiotic resistance genes and surface protein profiles of GBS are scarce in Ethiopia, a reason that this study was planned to investigate. . Read More

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http://dx.doi.org/10.1186/s12879-020-4776-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958622PMC
January 2020

Fertility factors affect the vaginal microbiome in women of reproductive age.

Am J Reprod Immunol 2020 Apr 21;83(4):e13220. Epub 2020 Jan 21.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Problem: For women of reproductive age, achieving a successful pregnancy requires both the normal functioning of reproductive endocrine and the health of the reproductive tract environment. We aimed to study how these fertility factors, such as female age, baseline sexual hormone levels, tubal patency, and vaginal pH, affect the composition of vaginal microbiome.

Method Of Study: The 16S rRNA sequencing was carried on vaginal microbiome samples from 85 women of reproductive age without vaginal infections or reproductive endocrine diseases. Read More

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http://dx.doi.org/10.1111/aji.13220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078941PMC

Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset group B streptococcal disease: a systematic review and meta-analysis.

BJOG 2020 05 4;127(6):680-691. Epub 2020 Feb 4.

Department of Paediatrics, Maastricht University Medical Centre, Maastricht, the Netherlands.

Background: Early-onset group B streptococcal (EOGBS) disease (including sepsis, meningitis, and pneumonia) causes significant morbidity and mortality in newborn infants worldwide. Antibiotic prophylaxis can prevent vertical streptococcal transmission, yet no uniform criteria exist to identify eligible women for prophylaxis. Some guidelines recommend universal GBS screening to pregnant women in their third trimester (screening-based protocol), whereas others employ risk-based protocols. Read More

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http://dx.doi.org/10.1111/1471-0528.16085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187465PMC

Can histology and haematology explain inapparent Streptococcus agalactiae infections and asymptomatic mortalities on Nile tilapia farms?

Res Vet Sci 2020 Apr 24;129:13-20. Epub 2019 Dec 24.

AQUOS - Aquatic Organisms Health Laboratory, Aquaculture Department, Federal University of Santa Catarina (CCA, UFSC), Rodovia Admar Gonzaga 1346, 88040-900 Florianópolis, SC, Brazil.

The aim of this study was to characterise possible histopathological and haemato-immunological changes after subclinical infection by S. agalactiae S13 serotype Ib. One hundred juveniles of Nile tilapia with average weight of 45 g were distributed in ten 90 L experimental units. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.12.018DOI Listing

Construction and characterization of a chimeric lysin ClyV with improved bactericidal activity against Streptococcus agalactiae in vitro and in vivo.

Appl Microbiol Biotechnol 2020 Feb 3;104(4):1609-1619. Epub 2020 Jan 3.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

The emergence of antibiotic-resistant beta-hemolytic Streptococcus agalactiae strains poses increasing threat to human beings globally. As an attempt to create a novel lysin with improved activity against S. agalactiae, a chimeric lysin, ClyV, was constructed by fusing the enzymatically active domain (EAD) from PlyGBS lysin (GBS180) and the cell wall binding domain (CBD) from PlyV12 lysin (V12CBD). Read More

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http://dx.doi.org/10.1007/s00253-019-10325-zDOI Listing
February 2020

A Case of Maternal Sepsis and Fetal Demise Associated with .

Case Rep Obstet Gynecol 2019 4;2019:4309191. Epub 2019 Dec 4.

Department of Obstetrics and Gynecology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

has recently been described in relation to its colonization of the female genitourinary tract. Since prior reports have linked only with minor morbidities, the organism previously has not been considered to be a cause of serious puerperal infections. A 41-year-old gravida 2, para 1-0-0-1 presented with abdominal pain and intrauterine fetal demise. Read More

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http://dx.doi.org/10.1155/2019/4309191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914956PMC
December 2019

Hydrogel Containing Oleoresin From Presents Antibacterial Activity Against .

Front Microbiol 2019 4;10:2806. Epub 2019 Dec 4.

Laboratório de Biologia Molecular de Microrganismos, Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.

or Group B (GBS) remains a leading cause of neonatal infections worldwide; and the maternal vaginal-rectal colonization increases the risk of vertical transmission of GBS to neonates and development of infections. This study reports the antibacterial effect of the oleoresin from Jacq. L. Read More

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http://dx.doi.org/10.3389/fmicb.2019.02806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904337PMC
December 2019

Distribution of Lactococcus spp. in New York State dairy farms and the association of somatic cell count resolution and bacteriological cure in clinical mastitis samples.

J Dairy Sci 2020 Feb 19;103(2):1785-1794. Epub 2019 Dec 19.

Animal Health Diagnostic Center, Quality Milk Production Services, Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853.

We investigated the distribution of pathogenic non-agalactiae gram-positive, catalase-negative cocci (GPCN) in a convenience sample of New York State dairy farms. Our primary objective with the clinical mastitis (CM) GPCN samples was to evaluate somatic cell count (SCC) resolution and bacteriological cure of Streptococcus dysgalactiae or Streptococcus uberis versus Lactococcus lactis or Lactococcus garvieae in cows that received an approved intramammary treatment. In phase I, we assessed the distribution of the GPCN and SCC resolution. Read More

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http://dx.doi.org/10.3168/jds.2018-16199DOI Listing
February 2020

Lethal infective endocarditis due to Streptococcus agalactiae in a man with a history of alcohol abuse: A case report.

Medicine (Baltimore) 2019 Dec;98(51):e18270

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi "Bonino Pulejo", Messina.

Rational: Infective endocarditis (IE) is defined as an infection of the endocardial surface of the heart, which may include one or more heart valves, the mural endocardium.

Patient Concerns: A 53-years-old man with a history of alcohol abuse was admitted in hospital for fever, paroxysmal atrial fibrillation cardioverted by Amiodarone and pulmonary infection.

Diagnosis: A case of recurrent severe endocarditis, with neurological complications both ischemic and hemorrhagic and heart failure caused by Streptococcus agalactiae in healthy man we reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000018270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940177PMC
December 2019

Epidemiology and resistance trends of Staphylococcus aureus isolated from vaginal samples: a 10-year retrospective study in Hungary.

Acta Dermatovenerol Alp Pannonica Adriat 2019 Dec;28(4):143-147

Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Introduction: The vaginal flora is a complex microbial environment. The disruption of this niche usually leads to a pathological state and symptoms in patients. Aerobic vaginitis is a distinct form of vaginal inflammation, mainly caused by aerobic/facultative anaerobic bacteria (Staphylococcus aureus, Streptococcus agalactiae, and members of the Enterobacteriaceae). Read More

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December 2019

Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women.

PLoS One 2019 18;14(12):e0226699. Epub 2019 Dec 18.

Department of Immunology and Microbiology, University of Colorado, Aurora, CO, United States of America.

Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a Gram-positive bacterium isolated from the vaginal tract of approximately 25% of women. GBS colonization of the female reproductive tract is of particular concern during pregnancy as the bacteria can invade gestational tissues or be transmitted to the newborn during passage through the birth canal. Infection of the neonate can result in life-threatening pneumonia, sepsis and meningitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226699PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919605PMC