Search Our Scientific Publications & Authors

Antioxidants (Basel) 2022 Jun 2;11(6). Epub 2022 Jun 2.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as , and . Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesized and secreted by the pineal gland and other organs, is ubiquitous throughout nature and has different effects on different tissues. Read More

Arch Microbiol 2022 Jun 15;204(7):394. Epub 2022 Jun 15.

Department of Fisheries and Aquatic Science, University of Cape Coast, Cape Coast, Ghana.

The modern and rapid avenue for detecting pathogens provided by molecular genetic techniques including polymerase chain reaction (PCR) was explored in the present study to identify prevalent disease pathogens, from six aquaculture farms and in two commonly cultured fish in Ghana. The specific detection was carried out directly on clinical samples of naturally infected fish (O. niloticus and C. Read More

Infez Med 2022 1;30(2):247-253. Epub 2022 Jun 1.

Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Bacterial vaginosis is a condition caused by changes in the vaginal microbial ecosystem and increases the risk of preterm delivery, premature rupture of membranes, endometritis, and weight loss of the baby. This study aimed to evaluate the frequency of gonococcal and non-gonococcal genital infections in women referred to clinics in Ilam, Iran. Two swab samples were taken from each patient using a sterile swab, one swab was placed in a THB medium for the culture of and the other in PBS buffer for PCR. Read More

Chin Med J (Engl) 2022 04 5;135(7):869-871. Epub 2022 Apr 5.

Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, China-Japan Friendship Hospital, Beijing 100029, China.

Microb Drug Resist 2022 Jun 3. Epub 2022 Jun 3.

Department of Infectious Diseases, KIMSHEALTH, Thiruvananthapuram, India.

Front Cell Infect Microbiol 2022 19;12:880943. Epub 2022 May 19.

Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

causes sepsis and meningitis in neonates, presenting substantial clinical challenges. Type VII secretion system (T7SS), an important secretion system identified in sp. and Gram-positive bacteria, was recently characterized in and considered to contribute to its virulence and pathogenesis. Read More

Fish Shellfish Immunol 2022 Jul 2;126:357-369. Epub 2022 Jun 2.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, PR China; Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, PR China. Electronic address:

NK-lysin, a homologue of granulysin among human, is predominantly found in natural killer cells and cytotoxic T-lymphocytes, which plays a pivotal part in innate immune responses against diverse pathogenic bacteria. Nonetheless, in teleosts, the research on antimicrobial activity and mechanisms of NK-lysin are seldom reported. In this study, we determined the antimicrobial activity of the truncated peptide TroNKL-27 that derived from golden pompano (Trachinotus ovatus) NK-lysin, and investigated its antimicrobial mechanisms. Read More

BMC Infect Dis 2022 Jun 4;22(1):517. Epub 2022 Jun 4.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Blood cultures remain the gold standard investigation for the diagnosis of bloodstream infections. In many locations, quality-assured processing of positive blood cultures is not possible. One solution is to incubate blood cultures locally, and then transport bottles that flag positive to a central reference laboratory for organism identification and antimicrobial susceptibility testing. Read More

Front Public Health 2022 16;10:851434. Epub 2022 May 16.

School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

Background: Maternal Group B Streptococcus (GBS) recto-vaginal colonization is the most common route for early onset neonatal GBS diseases. A good understanding of the rate of maternal GBS colonization, vertical transmission rate, and antibiotic susceptibility profiles is needed to formulate a broad protection mechanism, like vaccine preparation. For that reason, this meta-analysis aimed at determining the pooled prevalence of GBS recto-vaginal colonization, vertical transmission rate, and antibiotic susceptibility profiles in Ethiopia. Read More

Microbiol Spectr 2022 May 31:e0056822. Epub 2022 May 31.

Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Matsumoto, Japan.

This study aimed to investigate genomic traits underlying the antimicrobial resistance and virulence of multidrug-resistant (MDR) group B streptococci with reduced penicillin susceptibility (PRGBS) recovered from elderly patients with bloodstream infections, which remain poorly characterized. The pangenome was found to be open, with the predicted pan- and core genome sizes being 3,531 and 1,694 genes, respectively. Accessory and unique genes were enriched for the Clusters of Orthologous Groups (COG) categories L, Replication, recombination, and repair, and K, Transcription. Read More

J Fish Dis 2022 May 30. Epub 2022 May 30.

Fish Heath Platform, Center of Excellence for Shrimp Molecular Biology and Biotechnology (Centex Shrimp), Faculty of Science, Mahidol University, Bangkok, Thailand.

Tilapia parvovirus (TiPV) is an emerging virus reportedly associated with disease and mortality in farmed tilapia. Although previous descriptions of histopathological changes are available, the lesions reported in these are not pathognomonic. Here, we report Cowdry type A inclusion bodies (CAIB) in the pancreas as a diagnostic histopathological feature found in adult Nile tilapia naturally infected with TiPV. Read More

Cells 2022 05 13;11(10). Epub 2022 May 13.

Center for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, Germany.

Group B streptococci (GBS) cause a range of invasive maternal-fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. Read More

BMC Pregnancy Childbirth 2022 May 24;22(1):432. Epub 2022 May 24.

Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, EE, Estonia.

Background: Aerobic vaginitis (AV) is a vaginal inflammation characterized by disruption of the lactobacillus microbiota and increased counts of different aerobic bacteria. AV may result in severe complications, especially during pregnancy, including preterm delivery, neonatal and maternal infections. This study aimed to determine the prevalence of AV in the third trimester of pregnancy, and the relationship between AV and pregnancy outcomes. Read More

Sci Rep 2022 May 24;12(1):8754. Epub 2022 May 24.

GenoMar Genetics Group, Bolette Brygge 1, 0252, Oslo, Norway.

Disease outbreaks have been seen as the major threat to sustainable aquaculture worldwide. Injectable vaccines have been one of the few strategies available to control the diseases, however, the adoption of this technology globally is limited. Genetic selection for disease resistance has been proposed as the alternative strategy in livestock and aquaculture. Read More

Microbiol Spectr 2022 May 24:e0222421. Epub 2022 May 24.

University of Bydgoszcz, Bydgoszcz, Poland.

Streptococcus agalactiae can produce a wide variety of virulence factors, including toxins and proteins which facilitate adhesion to and colonization and invasion of the host cells. There are few reports on the characteristics of field isolates from bovine mastitis in Poland. Thus, the aim of this study was to determine the occurrence of types of hemolysis on blood agar, virulence factor genes, and cytotoxicity of S. Read More

Acta Biomed 2022 03 10;92(S3):e2021572. Epub 2022 Mar 10.

.

Introduction: Periprosthetic joint infection (PJI) is one of the most challenging complications following total hip arthroplasty. In early infection, within four to twelve weeks from surgery, debridement, antibiotics and implant retention (DAIR) can be the initial treatment. The aim of this study is to report our case series and review current concepts reported in the literature about this topic. Read More

Microbiol Spectr 2022 May 23:e0108222. Epub 2022 May 23.

Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

The prevalence and lineages of Streptococcus agalactiae (group B streptococci [GBS]) colonizing pregnant women are well studied, but less is known about colonization of nonpregnant adults. We characterized GBS colonization in adults as a potential reservoir for infections and tested for the presence of clones with a potentially higher invasive disease potential. We evaluated GBS gastrointestinal, genitourinary, and oral colonization among 336 nonpregnant adults in the community. Read More

Fish Shellfish Immunol 2022 Jul 19;126:34-46. Epub 2022 May 19.

Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan. Electronic address:

Nile tilapia (Oreochromis niloticus) is an important food fish species that is mainly cultivated in tropical and subtropical countries. However, microbial diseases have created various difficulties for this industry. The fundamental prerequisite for tackling disease outbreak prevention and disease resistance is to know how hosts' immune responses against invading microbes are initiated. Read More

Front Microbiol 2022 28;13:881549. Epub 2022 Apr 28.

Department of Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, Pavia, Italy.

Group B (GBS) is a Gram-positive bacterium able to switch from a harmless commensal of healthy adults to a pathogen responsible for invasive infections in neonates. The signals and regulatory mechanisms governing this transition are still largely unknown. CodY is a highly conserved global transcriptional regulator that links nutrient availability to the regulation of major metabolic and virulence pathways in low-G+C Gram-positive bacteria. Read More

Aten Primaria 2022 Jun 12;54(6):102366. Epub 2022 May 12.

OSI Ezkerraldea-Enkarterri-Cruces, Osakidetza, Bizkaia, España Centro de Salud Markonzaga, OSI Barakaldo-Sestao, Bizkaia, Osakidetza, Unidad Docente de Matronas del País Vasco, Área de Enfermería Clínica y Salud Comunitaria, Instituto de Investigación Sanitaria Biocruces Bizkaia, España.

Objetive: To evaluate the effectiveness of vagino-rectal swab autotomy for prenatal screening for GBS infection and to identify the barriers and facilitators encountered by the pregnant woman for this intervention.

Design: Cross-sectional study of diagnostic tests.

Participants And Site: A total of 213 pregnant women who attended the primary care midwife's office in 6 health centers of the Basque Health Service/Osakidetza in Bizkaia, who met the inclusion criteria and agreed to participate in the study, participated in the study. Read More

Int J Mol Sci 2022 Apr 29;23(9). Epub 2022 Apr 29.

Department of Pediatrics, Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada.

Group B (GBS) is a leading cause of placental infection, termed chorioamnionitis. Chorioamnionitis is associated with an increased risk of neurobehavioral impairments, such as autism spectrum disorders, which are more prominent in males than in female offspring. In a pre-clinical model of chorioamnionitis, a greater inflammatory response was observed in placenta associated with male rather than female fetuses, correlating with the severity of subsequent neurobehavioral impairments. Read More

Appl Environ Microbiol 2022 Jun 10;88(11):e0038322. Epub 2022 May 10.

Experimental Zooprophylactic Institute in Lombardy and Emilia Romagna, Brescia, Italy.

We report here on an outbreak of mastitis caused by Streptococcus agalactiae, or group B Streptococcus, in a northern Italy (Lombardy Region) free stall dairy farm. This outbreak was unusual because it occurred in a closed dairy herd and proved to be extremely difficult to resolve even after the application of the classical control procedures, which are specifically focused on the contagious nature of S. agalactiae. Read More

Crit Care 2022 05 9;26(1):130. Epub 2022 May 9.

Medicine (Pulmonology), University of Barcelona, Barcelona, Spain.

Background: The detection of coinfections is important to initiate appropriate antimicrobial therapy. Molecular diagnostic testing identifies pathogens at a greater rate than conventional microbiology. We assessed both bacterial coinfections identified via culture or the BioFire® FilmArray® Pneumonia Panel (FA-PNEU) in patients infected with SARS-CoV-2 in the ICU and the concordance between these techniques. Read More

PLoS One 2022 6;17(5):e0268262. Epub 2022 May 6.

College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.

Bovine mastitis is a common disease occurring in dairy farms and can be caused by more than 150 species of pathogenic bacteria. One of the most common causative organisms is Streptococcus agalactiae, which is also potentially harmful to humans and aquatic animals. At present, research on S. Read More

Lancet Glob Health 2022 06 28;10(6):e776-e777. Epub 2022 Apr 28.

Addis Ababa University, College of Health Science, Department of Microbiology, Immunology, and Parasitology, Addis Ababa, Ethiopia.

Lancet Glob Health 2022 06 28;10(6):e807-e819. Epub 2022 Apr 28.

Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Maternal, Adolescent, Reproductive & Child Health Centre, London School of Hygiene & Tropical Medicine, London, UK.

Background: Group B streptococcus (GBS) colonisation during pregnancy can lead to invasive GBS disease (iGBS) in infants, including meningitis or sepsis, with a high mortality risk. Other outcomes include stillbirths, maternal infections, and prematurity. There are data gaps, notably regarding neurodevelopmental impairment (NDI), especially after iGBS sepsis, which have limited previous global estimates. Read More

BMC Microbiol 2022 04 26;22(1):114. Epub 2022 Apr 26.

Department of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People's Hospital and the 6th affiliated Hospital of Guangdong Medical University, Shenzhen, 518052, China.

Background: The increasing emergence of multidrug-resistant Gram-positive bacterial infections necessitates new antibacterial agents with novel mechanisms of action that can be used to treat these infections. Lomitapide has been approved by FDA for years in reducing levels of low-density lipoprotein (LDL) in cases of familial hypercholesterolemia, whereas the antibacterial effect of lomitapide remains elusive. In this study, the inhibitory activities of lomitapide against Gram-positive bacteria were the first time explored. Read More

BMC Infect Dis 2022 Apr 22;22(1):396. Epub 2022 Apr 22.

Department of Respiratory and Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136, Jingzhou Street, Xiangcheng District, Hubei, 441021, China.

Background: Diabetic foot ulcer is one of the major complications for patients with diabetes, and has become an important cause of non-traumatic amputation. Necrotizing fasciitis is a life-threatening soft-tissue infection involving the fascia and subcutaneous tissue. When diabetic foot ulcers are complicated by necrotizing fasciitis (DNF), this increases the risk for amputation and mortality, making DNF treatment more complicated, and eventually leading to amputation and mortality. Read More

Pediatr Infect Dis J 2022 06 6;41(6):455-459. Epub 2022 May 6.

Pediatric Emergency Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Background: To describe the infants presenting to pediatric emergency departments (PEDs) and diagnosed with group B Streptococcus (GBS) late-onset disease (LOD) bacteremia and identify risk factors for severe infection and pediatric intensive care unit (PICU) admission.

Methods: Observational study and subanalysis of a multicenter prospective registry. Setting: pediatric emergency department. Read More

Pediatr Infect Dis J 2022 06 6;41(6):e263-e266. Epub 2022 May 6.

From the Neonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.