103,093 results match your criteria Streptococcus Group B Infections


Crystal structure of GAPDH of Streptococcus agalactiae and characterization of its interaction with extracellular matrix molecules.

Microb Pathog 2018 Dec 12. Epub 2018 Dec 12.

Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, 600025, India. Electronic address:

GAPDH being a key enzyme in the glycolytic pathway is one of the surface adhesins of many Gram-positive bacteria including Streptococcus agalactiae. This anchorless adhesin is known to bind to host plasminogen (PLG) and fibrinogen (Fg), which enhances the virulence and modulates the host immune system. The crystal structure of the recombinant GAPDH from S. Read More

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December 2018

The Impact of Prefilled Syringes on Endophthalmitis following Intravitreal Injection of Ranibizumab.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Purpose: To compare the rates of infectious endophthalmitis following intravitreal injection of ranibizumab using prefilled syringes vs. conventional preparation.

Design: Multicenter, retrospective, cohort study METHODS: All eyes receiving intravitreal injection of 0. Read More

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December 2018

Positive influence of simvastatin used as adjuvant agent for cavity lining.

Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Pathology, Araraquara School of Dentistry, São Paulo State University (Unesp), Rua Humaitá, 1680, Araraquara, SP, 14801-903, Brazil.

Objectives: To assess the biological, antimicrobial, and mechanical effects of the treatment of deep dentin with simvastatin (SV) before application of a glass-ionomer cement (GIC).

Materials And Methods: Dentin discs were adapted to artificial pulp chambers and SV (2.5 or 1. Read More

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December 2018

Detection of Pediatric Bacterial Meningitis Pathogens from Cerebrospinal Fluid by Next-Generation Sequencing Technology.

J Infect 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China. Electronic address:

Objectives: Bacterial meningitis remains one of the major challenges in infectious diseases, leading to sequel in many cases. A prompt diagnosis of the causative microorganism is critical to significantly improve outcome of bacterial meningitis. Although various targeted tests for cerebrospinal fluid (CSF) samples are available, it is a big problem for the identification of etiology of bacterial meningitis. Read More

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December 2018

Identification and immune-related analysis of SNPs in Litopenaeus vannamei Toll3 receptor.

Immunol Lett 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China. Electronic address:

Tolls and Toll-like receptors (TLRs), as innate immune-recognition receptors that recognize molecular patterns associated with microbial pathogens, play a critical role in antimicrobial immune responses. Here, we report on single nucleotide polymorphisms (SNPs) of Litopenaeus vannamei Toll3 (LvToll3). Multiple sequence alignment of the L. Read More

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December 2018

Comparison of the Photosensitivity of Biofilms of Different Genera of Cariogenic Bacteria in Tooth Slices.

Pol J Microbiol 2018 ;67(4):455-462

Department of Physics, Faculty of Science and Arts, Jordan University of Science and Technology , Irbid , Jordan.

This study compared the outcome of photosensitization on the viability of four different cariogens in planktonic form as well as biofilms in human dentine. Photodynamic therapy was carried out with a gallium aluminium arsenide laser (670 nm wavelength) using Toluidine blue O (TBO) as the photosensitizer. Cariogenic bacteria ( Streptococcus mutans , Lactobacillus casei , Streptococcus salivarius and Actinomyces viscosus ) were exposed to TBO and then to the laser for 1 minute in planktonic suspension. Read More

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January 2018

Capsular polysaccharide of Streptococcus agalactiae is an essential virulence factor for infection in Nile tilapia (Oreochromis niloticus Linn.).

J Fish Dis 2018 Dec 14. Epub 2018 Dec 14.

Core Facility for Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Streptococcus agalactiae (Group B Streptococcus, GBS) is associated with diverse diseases in aquatic animals. The capsule polysaccharide (CPS) encoded by the cps gene cluster is the major virulence factor of S. agalactiae; however, limited information is available regarding the pathogenic role of the CPS of serotype Ia piscine GBS strains in fish. Read More

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December 2018

Human native endocarditis caused by Streptococcus canis-a case report.

APMIS 2019 Jan;127(1):41-44

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.

We report a very rare case of Streptococcus canis native infective endocarditis in a 73-year-old woman living in close contact with her dog. Her echocardiography showed large calcifications in the mitral annulus, massive regurgitation below the posterior leaflet, and adjacent vegetation. Blood culture was positive for Streptococcus Lancefield group G. Read More

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January 2019
2 Reads

In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa.

Vet Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, 5371, Australia.

Background: An antibiotic adjuvant is a chemical substance used to modify or augment the effectiveness of primary antimicrobial agents against drug-resistant micro-organisms. Its use provides an alternative approach to address the global issue of antimicrobial resistance and enhance antimicrobial stewardship.

Hypothesis/objectives: To determine the antimicrobial activity of a panel of potential antimicrobial adjuvants against common pathogens associated with canine otitis externa (OE). Read More

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December 2018
1 Read

Similarities and Differences Between Staphylococcal and Streptococcal Toxic Shock Syndromes in Children: Results From a 30-Case Cohort.

Front Pediatr 2018 28;6:360. Epub 2018 Nov 28.

Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Centre de Biologie et de Pathologie Nord, Hospices Civils de Lyon, Lyon, France.

Toxic shock syndromes (TSS) are severe shocks due to staphylococcal or streptococcal infection that require specific treatments. The early recognition of these shocks is crucial to improve their outcomes. The primary objective of this study was to compare characteristics and outcomes of staphylococcal and streptococcal TSS in children, in order to identify putative early clinical diagnostic criteria. Read More

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November 2018

Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon.

Nat Microbiol 2019 Jan 10;4(1):198-208. Epub 2018 Dec 10.

Department of Microbiology, New York University School of Medicine, New York, NY, USA.

Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. Read More

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January 2019

Epidemiology of bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal nation-wide cohort study.

Leukemia 2018 Dec 13. Epub 2018 Dec 13.

Department of Haematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Patients with chronic lymphocytic leukemia (CLL) have a high risk of bloodstream infections (BSI). BSI cause significant morbidity and mortality among CLL patients; approximately one-third of fatalities in CLL list infections as cause of death. All CLL patients in Denmark diagnosed between 2008 and 2016 were followed through registries for the event of a BSI. Read More

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December 2018

Bacterial profile of the supragingival dental biofilm in children with deciduous and early mixed dentition using next generation sequencing (HOMINGS) technique.

Enferm Infecc Microbiol Clin 2018 Dec 10. Epub 2018 Dec 10.

Servicio de Microbiología Oral, Clínica Odontológica de la Corporación Universitaria Rafael Núñez, Cartagena, Colombia.

Objective: Tdescribe the bacterial profile of the supragingival biofilm of children with temporary dentition (CTD) and early mixed dentition (CEMD), with the next-generation sequencing (HOMINGS) technique.

Method: A comparative descriptive study was carried out with 30 systemically healthy children aged between 5 and 7 years old from public schools in Cartagena-Colombia. All participants were caries-free applying the criteria of the International Caries Detection and Assessment System (ICDAS II) and had no caries experience according to the Decayed, Missing and Filled Teeth (DMFT) index. Read More

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December 2018

A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?

Microbiome 2018 Dec 13;6(1):221. Epub 2018 Dec 13.

University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada.

Background: Immune-mediated inflammatory disease (IMID) represents a substantial health concern. It is widely recognized that IMID patients are at a higher risk for developing secondary inflammation-related conditions. While an ambiguous etiology is common to all IMIDs, in recent years, considerable knowledge has emerged regarding the plausible role of the gut microbiome in IMIDs. Read More

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December 2018

Probiotics Streptococcus salivarius 24SMB and Streptococcus oralis 89a interfere with biofilm formation of pathogens of the upper respiratory tract.

BMC Infect Dis 2018 Dec 13;18(1):653. Epub 2018 Dec 13.

Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy.

Background: Infections of the ears, paranasal sinuses, nose and throat are very common and represent a serious issue for the healthcare system. Bacterial biofilms have been linked to upper respiratory tract infections and antibiotic resistance, raising serious concerns regarding the therapeutic management of such infections. In this context, novel strategies able to fight biofilms may be therapeutically beneficial and offer a valid alternative to conventional antimicrobials. Read More

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December 2018

Climate Change and Goat Production: Enteric Methane Emission and Its Mitigation.

Animals (Basel) 2018 Dec 7;8(12). Epub 2018 Dec 7.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.

The ability of an animal to cope and adapt itself to the changing climate virtually depends on the function of rumen and rumen inhabitants such as bacteria, protozoa, fungi, virus and archaea. Elevated ambient temperature during the summer months can have a significant influence on the basic physiology of the rumen, thereby affecting the nutritional status of the animals. Rumen volatile fatty acid (VFA) production decreases under conditions of extreme heat. Read More

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December 2018

Group A streptococcal DNase Sda1 impairs plasmacytoid dendritic cell's type I interferon response.

J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address:

Group A Streptococcus causes severe invasive infections, including necrotizing fasciitis. The expression of an array of virulence factors targeting specific host immune functions impedes successful bacterial clearance. The virulence factor streptococcal DNase Sda1 was previously shown to interfere with the entrapment of bacteria through neutrophil extracellular traps and TLR9 signaling. Read More

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December 2018
1 Read

Strategies to improve antibiotic use in the neonatal ICU.

Curr Opin Pediatr 2018 Dec 12. Epub 2018 Dec 12.

Division of Pediatric Infectious Diseases, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Neonates are at a high risk of infection and may have nonspecific signs of sepsis. Accordingly, they are heavily exposed to antimicrobials. Neonates are also uniquely at risk of both short-term and long-term complications from antibiotic exposure. Read More

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December 2018

The Streptococcos suis sortases SrtB and SrtF are essential for disease in pigs.

Microbiology 2018 Dec 13. Epub 2018 Dec 13.

1​Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

The porcine pathogen Streptococcus suis colonizes the upper respiratory tracts of pigs, potentially causing septicaemia, meningitis and death, thus placing a severe burden on the agricultural industry worldwide. It is also a zoonotic pathogen that is known to cause systemic infections and meningitis in humans. Understanding how S. Read More

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December 2018

Anticaries activity of egg ovalbumin in an experimental caries biofilm model on enamel and dentin.

Clin Oral Investig 2018 Dec 12. Epub 2018 Dec 12.

Cariology Unit, Department of Oral Rehabilitation, University of Talca, 1 poniente 1141, Escuela de Odontología, Talca, Chile.

Objectives: Limited evidence suggests a putative inhibitory effect of dietary proteins on demineralization during the carious process. The aim was to explore a potential anticaries activity of the egg protein ovalbumin on a relevant in vitro approach.

Materials And Methods: Biofilms of Streptococcus mutans UA159 were formed on saliva-coated enamel and dentin bovine slabs. Read More

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December 2018

Recovery and Purity of High Molar Mass Bio-hyaluronic Acid Via Precipitation Strategies Modulated by pH and Sodium Chloride.

Appl Biochem Biotechnol 2018 Dec 12. Epub 2018 Dec 12.

Development of Biotechnological/Microbial Processes Laboratory, School of Chemical Engineering, University of Campinas, Av. Albert Einstein, 500, Campinas, São Paulo, 13083-852, Brazil.

The effects of ethanol/broth proportions and the number of steps at varying pH in the presence or absence of sodium chloride (NaCl) were studied as precipitation strategies for the recovery and purification of high molar mass bio-hyaluronic acid (Bio-HA). Bio-HA was synthesized by Streptococcus zooepidemicus in a culture medium containing glucose and soy peptones. A single-step precipitation was more attractive than multistep precipitation in terms of recovery and purity as well as decreased use of ethanol. Read More

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December 2018

Antimicrobial resistance in bacterial pathogens among hospitalised patients with severe invasive infections.

Exp Ther Med 2018 Dec 14;16(6):4499-4510. Epub 2018 Sep 14.

Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

The most severe infections are invasive infections, due to the fact that the germs can accumulate in multiple sites and produce a body-wide infection known as sepsis. Septic shock has the highest mortality rate among non-traumatic medical conditions. In this study, we aimed to evaluate the incidence and prevalence of invasive infections in a hospital environment. Read More

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December 2018

Complement Activation Occurs at the Surface of Platelets Activated by Streptococcal M1 Protein and This Results in Phagocytosis of Platelets.

J Immunol 2018 Dec 12. Epub 2018 Dec 12.

Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden

Platelets circulate the bloodstream and principally maintain hemostasis. Disturbed hemostasis, a dysregulated inflammatory state, and a decreased platelet count are all hallmarks of severe invasive infection, sepsis. We have previously demonstrated that the released M1 protein from activates platelets, and this activation is dependent on the binding of M1 protein, fibrinogen, and M1-specific IgG to platelets in susceptible donors. Read More

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December 2018

[Microbiological analysis of the maternal genital tract and umbilical cord blood and its association with neonatal damage].

Rev Argent Microbiol 2018 Dec 9. Epub 2018 Dec 9.

Laboratorio de Bacteriología Clínica, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba, CABA, Argentina. Electronic address:

The etiology leading to neonatal damage is multifactorial, being genital infections one of the causes. The objective of the study was to identify microorganisms of the maternal genital tract that are associated with neonatal damage, in order to prevent future perinatal complications. Seven hundred and eleven pregnant patients attended their prenatal control during the period January 2010-July 2013. Read More

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December 2018

Screening of Streptococcus Suis serotype 2 resistance genes with GWAS and transcriptomic microarray analysis.

BMC Genomics 2018 Dec 12;19(1):907. Epub 2018 Dec 12.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.

Background: Swine streptococcosis has caused great economic loss in the swine industry, and the major pathogen responsible for this disease is Streptococcus Suis serotype 2 (SS2). Disease resistance breeding is a fundamental way of resolving this problem. With the development of GWAS and transcriptomic microarray technology, we now have powerful research tools to identify SS2 resistance genes. Read More

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December 2018

Enhanced design and formulation of nanoparticles for anti-biofilm drug delivery.

Nanoscale 2018 Dec 7. Epub 2018 Dec 7.

Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA. and Center for Oral Biology, University of Rochester, Rochester, New York, USA and Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA and Department of Chemical Engineering, University of Rochester, Rochester, New York, USA.

Biofilms are surface-bound, structured microbial communities underpinning persistent bacterial infections. Biofilms often create acidic pH microenvironments, providing opportunities to leverage responsive drug delivery systems to improve antibacterial efficacy. Here, the antibacterial efficacy of novel formulations containing pH-responsive polymer nanoparticle carriers (NPCs) and farnesol, a hydrophobic antibacterial drug, were investigated. Read More

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December 2018
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Dysbiosis of the Salivary Microbiome Is Associated With Non-smoking Female Lung Cancer and Correlated With Immunocytochemistry Markers.

Front Oncol 2018 20;8:520. Epub 2018 Nov 20.

College of Life Science, Shandong Normal University, Jinan, China.

Association between oral bacteria and increased risk of lung cancer have been reported in several previous studies, however, the potential association between salivary microbiome and lung cancer in non-smoking women have not been evaluated. There is also no report on the relationship between immunocytochemistry markers and salivary microbiota. In this study, we assessed the salivary microbiome of 75 non-smoking female lung cancer patients and 172 matched healthy individuals using 16S rRNA gene amplicon sequencing. Read More

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November 2018

When kidneys and lungs suffer together.

J Nephrol 2018 Dec 6. Epub 2018 Dec 6.

University of Insubria, Varese, Italy.

A significant interaction between kidneys and lungs has been shown in physiological and pathological conditions. The two organs can both be targets of the same systemic disease (eg., some vasculitides). Read More

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December 2018
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Blindness as an uncommon complication of Streptococcus pneumoniae systemic infection.

Intensive Care Med 2018 Dec 6. Epub 2018 Dec 6.

Faculté de Médecine, Hôpitaux universitaires de Strasbourg, Service de Réanimation Médicale, Nouvel Hôpital Civil, Université de Strasbourg (UNISTRA), 1 place de l'Hôpital, 67000, Strasbourg, France.

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December 2018

Uncovering complex microbiome activities via metatranscriptomics during 24 hours of oral biofilm assembly and maturation.

Microbiome 2018 Dec 6;6(1):217. Epub 2018 Dec 6.

Department of Periodontics, University of Washington, Seattle, WA, 98195, USA.

Background: Dental plaque is composed of hundreds of bacterial taxonomic units and represents one of the most diverse and stable microbial ecosystems associated with the human body. Taxonomic composition and functional capacity of mature plaque is gradually shaped during several stages of community assembly via processes such as co-aggregation, competition for space and resources, and by bacterially produced reactive agents. Knowledge on the dynamics of assembly within complex communities is very limited and derives mainly from studies composed of a limited number of bacterial species. Read More

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December 2018

Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.

PLoS One 2018 12;13(12):e0207574. Epub 2018 Dec 12.

Department of Operative Dentistry and Periodontology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In light of the growing antibiotic resistance, the usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against oral infections. The aim of this study was to investigate the antimicrobial and antibiofilm activity of Mediterranean herb extracts against representative oral microorganisms. The extraction procedures and the analysis of the obtained extracts were performed under established experimental conditions. Read More

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December 2018

Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota: An Observational Pilot Study.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Department of Biotechnology, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.

Background And Objectives: Breast milk contains several bioactive factors including human milk oligosaccharides (HMOs) and microbes that shape the infant gut microbiota. HMO profile is determined by secretor status; however, their influence on milk microbiota is still uncovered. This study is aimed to determine the impact of the FUT2 genotype on the milk microbiota during the first month of lactation and the association with HMO. Read More

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December 2018
1 Read

Snow angels - the microbiology of freshly fallen snow: implications for immunocompromised patients.

J Water Health 2018 Dec;16(6):1029-1032

Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, UK E-mail: School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK and Centre for Experimental Medicine, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.

The frequency of seasonal snowfall results in the transient covering of gardens/amenity sites/open public spaces, which encourages recreational interaction mainly with children. No data is available demonstrating the microbiological composition of such fallen snow and therefore a study was undertaken to examine the microbiology of snow from 37 sites, estimating (i) total viable count (TVC), (ii) identification of bacteria, and (iii) the presence of Pseudomonas aeruginosa. Mean TVC count of 8. Read More

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December 2018

Development and characterization of a novel bulk-fill elastomeric temporary restorative composite.

J Appl Oral Sci 2018 Dec 10;27:e20180183. Epub 2018 Dec 10.

Universidade Federal de Pelotas, Faculdade de Odontologia, Programa de Pós-Graduação em Odontologia (PPGO), Pelotas, Rio Grande do Sul, Brasil.

Objectives: This study investigated the physical and mechanical properties, antibacterial effect and biocompatibility of novel elastomeric temporary resin-based filling materials (TFMs) containing zinc methacrylate (ZM).

Material And Methods: Experimental TFMs were prepared by mixing the zinc methacrylate with monomer, co-monomer, photoinitiator and fillers. A ZM concentration of 0 (control), 0. Read More

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December 2018
1 Read

Inhibitory effect of reduced graphene oxide-silver nanocomposite on progression of artificial enamel caries.

J Appl Oral Sci 2018 Dec 10;27:e20180042. Epub 2018 Dec 10.

Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Guanghua School of Stomatology, Guangzhou, China.

Objectives: The use of antimicrobial agents is an efficient method to prevent dental caries. Also, nanometric antibacterial agents with wide antibacterial spectrum and strong antibacterial effects can be applied for prevention of dental caries. The aim of this study was to evaluate the inhibitory effect of reduced graphene oxide-silver nanoparticles (rGO/Ag) composite on the progression of artificial enamel caries in a Streptococcus mutans biofilm model. Read More

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December 2018
2 Reads

Management of Group B Streptococcus-Positive Women With Preterm Premature Rupture of the Membranes: Still a Therapeutic Dilemma.

J Obstet Gynaecol Can 2018 Dec 24;40(12):1627-1631. Epub 2018 Oct 24.

Faculty of Medicine, Dalhousie University, Halifax, NS; Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, NS.

We discuss the management of GBS positive women with PPROM, an aspect of obstetrical management that remains controversial despite the publication of new randomized control trials in recent years. Clinical practice guidelines from several countries' national organizations are compared and contrasted, and areas of uncertainty are identified. Read More

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December 2018

Dietary supplementation of Streptococcus faecalis benefits the feed utilization, antioxidant capability, innate immunity, and disease resistance of blunt snout bream (Megalobrama amblycephala).

Fish Physiol Biochem 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

This study aimed to investigate the effects of Streptococcus faecalis on the growth performance, intestinal histology, antioxidant capability, innate immunity, and disease resistance of blunt snout bream Megalobrama amblycephala. Fish were fed five experimental diets containing 0 (SF0, control), 1 × 10 (SF1), 1 × 10 (SF2), 1 × 10 (SF3), and 1 × 10 cfu/g (SF4) of Streptococcus faecalis, respectively, for 10 weeks. After the feeding trial, fish were challenged by Aeromonas hydrophila with the cumulative mortality recorded during a period of 96 h. Read More

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December 2018

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

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November 2018
1 Read

Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China.

Infect Drug Resist 2018 26;11:2461-2469. Epub 2018 Nov 26.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: causes serious infections globally, including invasive pneumococcal disease (IPD). We analyze clinical features of pediatric IPD cases identified in China and antibiotic susceptibility of isolated pneumococcal strains.

Methods: Confirmed pediatric IPD patients were prospectively recruited to the study. Read More

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November 2018

Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.

Int J Nanomedicine 2018 19;13:7697-7709. Epub 2018 Nov 19.

Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China,

Background: Oral plaque biofilms pose a threat to periodontal health and are challenging to eradicate. There is a growing belief that a combination of silver nanoparticles and chlorhexidine (CHX) is a promising strategy against oral biofilms.

Purpose: To overcome the side effects of this strategy and to exert maximum efficiency, we fabricated biodegradable disulfide-bridged mesoporous silica nanoparticles (MSNs) to co-deliver silver nanoparticles and CHX for biofilm inhibition. Read More

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November 2018

Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia

The World Health Organization reports that antibiotic-resistant pathogens represent an imminent global health disaster for the 21st century. Gram-positive superbugs threaten to breach last-line antibiotic treatment, and the pharmaceutical industry antibiotic development pipeline is waning. Here we report the synergy between ionophore-induced physiological stress in Gram-positive bacteria and antibiotic treatment. Read More

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December 2018

Developing a highly efficient and wildly adaptive CRISPR-SaCas9 toolset for plant genome editing.

Plant Biotechnol J 2018 Dec 10. Epub 2018 Dec 10.

Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, China.

The CRISPR- Streptococcus pyogenes Cas9 (SpCas9) system offers a rapid, simple and flexible genome editing approach. However, the targeting scope of the SpCas9 system is limited by the canonical NGG PAM. To broaden the editing range of the CRISPR system, several Cas orthologs recognized different PAM were isolated from diverse microbes and were engineered as powerful genome editing tools in eukaryotic cells (Murovec et al. Read More

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December 2018
2 Reads

Measuring quantity and function of pneumococcal antibodies in immunoglobulin products.

Transfusion 2018 Dec;58 Suppl 3:3114-3120

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Immunoglobulin replacement therapy is a cornerstone of the treatment of primary immunodeficiencies. Preparations used for replacement therapy are processed by purifying immunoglobulins from large pools of plasma, which were obtained from healthy donors. The constituent antibodies in these products depend on the immune history of the donor pool as well as manufacturing processes that differ among manufacturers. Read More

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December 2018
2 Reads

Overview of antibody-mediated immunity to S. pneumoniae: pneumococcal infections, pneumococcal immunity assessment, and recommendations for IG product evaluation.

Transfusion 2018 Dec;58 Suppl 3:3106-3113

Regional Immunology Service, The Royal Hospitals, Belfast Health & Social Care Trust and Queen's University Belfast, Belfast, UK.

Streptococcus pneumoniae (S. pneumoniae) strains colonize the nasopharynx and can cause mucosal infections in the upper airway and middle ear, pneumonias, and invasive infections like bacteremia, sepsis, and meningitis. Over 90 serotypes, defined by the structure of their capsular polysaccharides, are known. Read More

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December 2018
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Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis.

Dermatol Ther (Heidelb) 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Introduction: Erysipelas and bacterial cellulitis are two of the most common infectious skin diseases. They are usually caused by the β-hemolytic group of Streptococcus, and less frequently by other bacteria. The objective of the study was to assess the factors affecting the length of stay of patients admitted to hospital with erysipelas or bacterial cellulitis. Read More

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December 2018
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Intestinal Microbiota Is Altered in Patients with Gastric Cancer from Shanxi Province, China.

Dig Dis Sci 2018 Dec 7. Epub 2018 Dec 7.

Immunology Department, Shanxi Cancer Hospital, No. 3 Zhigong New Street, Taiyuan, 030013, Shanxi, China.

Background: Many diseases have been associated with intestinal microbial dysbiosis. Host-microbial interactions regulate immune function, which influences the development of gastric cancer.

Aims: The aims were to investigate the characteristics of intestinal microbiota composition in gastric cancer patients and correlations between the intestinal microbiota and cellular immunity. Read More

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December 2018
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2.550 Impact Factor

Putative Microbial Population Shifts Attributable to Nasal Administration of Streptococcus salivarius 24SMBc and Streptococcus oralis 89a.

Probiotics Antimicrob Proteins 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Galeazzi 4, 20164, Milan, Italy.

Changes in bacterial composition of nasal microbiota may alter the host's susceptibility to several infectious and allergic diseases such as chronic rhinosinusitis and allergic rhinitis. The aim of this study was to evaluate the effects of 1-week administration of a probiotic product, composed by a combination of Streptococcus salivarius 24SMBc and Streptococcus oralis 89a, on the nostril microbiota. Differences in the nasal microbiota composition were investigated by using a next-generation sequencing approach. Read More

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December 2018

Suhuai suckling piglet hindgut microbiome-metabolome responses to different dietary copper levels.

Appl Microbiol Biotechnol 2018 Dec 7. Epub 2018 Dec 7.

Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

Unabsorbed copper accumulates in the hindgut of pigs that consume high levels of dietary copper, which enhances the coselection of antibiotic-resistant bacteria and is considered detrimental to the environment and to porcine health. In our study, a combination of 16S rRNA pyrosequencing and nontargeted metabolomics was used to investigate the microbiome-metabolome responses to dietary copper levels in the hindgut of suckling piglets. The results showed that the dietary copper level affected the abundance of several Clostridia genera and that the relative abundance of butyrate-producing bacteria, such as Coprococcus, Roseburia, and Acidaminococcus, was reduced in the 300 mg kg (high) Cu group. Read More

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December 2018