7,273 results match your criteria Streptococcus Group B Infections


Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19.

Virol Sin 2021 May 12. Epub 2021 May 12.

CAS Key Laboratory of Special Pathogens and Biosafety, Centre for Biosafety Mega-Sciences, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

As a respiratory tract virus, SARS-CoV-2 infected people through contacting with the upper respiratory tract first. Previous studies indicated that microbiota could modulate immune response against pathogen infection. In the present study, we performed metagenomic sequencing of pharyngeal swabs from eleven patients with COVID-19 and eleven Non-COVID-19 patients who had similar symptoms such as fever and cough. Read More

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Control of Streptococcal Infections: Is a Common Vaccine Target Achievable Against and .

Front Microbiol 2021 23;12:658824. Epub 2021 Apr 23.

West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.

Both [group B streptococcus (GBS)] and (pneumococcus) remain significant pathogens as they cause life threatening infections mostly in children and the elderly. The control of diseases caused by these pathogens is dependent on antibiotics use and appropriate vaccination. The introduction of the pneumococcal conjugate vaccines (PCVs) against some serotypes has led to reduction in pneumococcal infections, however, the subsequent serotype switching, and replacement has been a serious challenge. Read More

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Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish.

Front Mol Biosci 2021 15;8:644957. Epub 2021 Apr 15.

Center for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria. Phagocytosis serves as the first line defense in innate immunity that engulfs bacteria and restricts their proliferations and invasions. However, the mechanism underlying the regulation of phagocytosis is not fully elucidated and the way to boost phagocytosis is not yet explored. Read More

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Vaccine Efficacy of a Newly Developed Feed-Based Whole-Cell Polyvalent Vaccine against Vibriosis, Streptococcosis and Motile Aeromonad Septicemia in Asian Seabass, .

Vaccines (Basel) 2021 Apr 10;9(4). Epub 2021 Apr 10.

Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

Multiple infections of several bacterial species are often observed under natural farm conditions. The infections would cause a much more significant loss compared to a single infectious agent. Vaccination is an essential strategy to prevent diseases in aquaculture, and oral vaccination has been proposed as a promising technique since it requires no handling of the fish and is easy to perform. Read More

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Clinical Laboratory Perspective on Streptococcus halichoeri, an Unusual Nonhemolytic, Lancefield Group B Streptococcus Causing Human Infections.

Emerg Infect Dis 2021 May;27(5):1309-1316

Streptococcus halichoeri is a relatively newly identified species of pyogenic streptococci that causes zoonotic infection in humans. S. halichoeri was first described in 2004 as indigenous to seals, and only 8 reports of human S. Read More

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Cytokine Profiles Before and After Exchange Transfusions in Severe Late-Onset Neonatal Group B Streptococcus Meningitis: A Case Report.

Tohoku J Exp Med 2021 04;253(4):269-273

Department of Pediatrics, Ohta Nishinouchi Hospital.

Streptococcus agalactiae or group B streptococcus (GBS) is a pathogen that causes severe neonatal infections, resulting in sepsis, pneumonia, and meningitis. Neonatal GBS meningitis has a poor neurological prognosis and a high mortality rate. GBS disease is classified as early- and late-onset if the onset age is 0-6 and 7-89 days after birth, respectively. Read More

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IL-17A secreted by Th17 cells is essential for the host against infections.

J Microbiol Biotechnol 2021 Apr 21. Epub 2021 Apr 21.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, P.R. China.

is an important bacterial pathogen that is the causative agent of diseases, including neonatal sepsis and meningitis, and infections in pregnant women and non-pregnant adults. Although antibiotic treatments effectively relieve symptoms, the emergence and transmission of multidrug-resistant strains indicate the need for an effective immunotherapy. Effector T helper (Th) 17 cells is a relatively newly discovered subpopulation of helper CD4 T lymphocytes, by expressing interleukin (IL)-17A play crucial roles in host defenses against a variety of pathogens, including bacteria and viruses. Read More

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Functional Study of the Type II-A CRISPR-Cas System of Hypervirulent Strains.

CRISPR J 2021 Apr;4(2):233-242

ISP, Université de Tours, INRAE, Tours, France; Dangé-Saint-Romain, France.

Nearly all strains of , the leading cause of invasive infections in neonates, encode a type II-A clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system. Interestingly, strains belonging to the hypervirulent Sequence Type 17 (ST17) contain significantly fewer spacers in their CRISPR locus than other lineages, which could be the result of a less functional CRISPR-Cas system. Here, we revealed one large deletion in the ST17 promoter region and we evaluated its impact on the transcription of genes as well as the functionalities of the CRISPR-Cas system. Read More

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Immuno-protective efficiency of feed-based whole-cell inactivated bivalent vaccine against Streptococcus and Aeromonas infections in red hybrid tilapia (Oreochromis niloticus × Oreochromis mossambicus).

Fish Shellfish Immunol 2021 Jun 12;113:162-175. Epub 2021 Apr 12.

Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia; Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. Electronic address:

Streptococcosis and motile aeromonad septicemia (MAS) are well-known diseases in tilapia culture, which cause mass mortality with significant economic losses. The development of feed-based bivalent vaccines in controlling these diseases has been initiated, however, the mechanisms of immunities and cross-protection in fish remain unclear. This study was conducted to assess the immuno-protective as well as the cross-protective efficacy of a newly developed feed-based bivalent vaccine against Streptococcus and Aeromonas infections in red hybrid tilapia. Read More

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Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival.

Commun Biol 2021 Apr 13;4(1):467. Epub 2021 Apr 13.

Graduate School of Life Science, University of Hyogo, Ako, Hyogo, Japan.

Hemes (iron-porphyrins) are critical for biological processes in all organisms. Hemolytic bacteria survive by acquiring b-type heme from hemoglobin in red blood cells from their animal hosts. These bacteria avoid the cytotoxicity of excess heme during hemolysis by expressing heme-responsive sensor proteins that act as transcriptional factors to regulate the heme efflux system in response to the cellular heme concentration. Read More

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The association between imbalances in vaginal microflora and duration of pregnancy as well as selected maternal and neonatal parameters.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Objectives: Abnormal vaginal flora (AVF) is a result of excessive growth of some aerobic bacteria and fungi in relation to the scarce presence of Lactobacillus spp. It has been suggested that AVF is responsible for preterm birth and such neonatal conditions as infections or sepsis. The aim of the study was to assess the influence of excessive vaginal colonization with aerobic bacteria and fungi on the selected postnatal parameters of newborns, duration of pregnancy and length of hospitalisation of neonates. Read More

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In-laboratory quality control of nutrients for automatic bacteriology analyzer YUNON®Labstar 50.

Klin Lab Diagn 2021 Mar;66(2):110-114

Regional Children's Clinical Hospital, clinical microbiology laboratory.

The quality of culture media for blood culture was checked: nutrient medium for children with an antibiotic neutralizer for the cultivation of aerobes, nutrient medium with an antibiotic neutralizer for the cultivation of anaerobes, a nutrient medium with an antibiotic neutralizer for the cultivation of aerobes, nutrient medium for the cultivation of aerobes UNONA® used in the automatic bacteriological analyzer JUNONA ®Labstar 50 (SCENKER Biological Technology Co., Ltd. China). Read More

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Clinical features and outcome of Streptococcus agalactiae bone and joint infections over a 6-year period in a French university hospital.

PLoS One 2021 12;16(3):e0248231. Epub 2021 Mar 12.

Department of Infectious and Tropical Disease, VBMI, INSERM U1407, CHU Nîmes, Univ Montpellier, Nîmes, France.

Background: Bone and joint infections (BJIs) due to Streptococcus agalactiae are rare but has been described to increase in the past few years. The objective of this study was to describe clinical features and outcomes of cases of S. BJIs. Read More

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Genome-Wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits.

PLoS Pathog 2021 Mar 8;17(3):e1009116. Epub 2021 Mar 8.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

Streptococcus agalactiae (group B Streptococcus; GBS) remains a dominant cause of serious neonatal infections. One aspect of GBS that renders it particularly virulent during the perinatal period is its ability to invade the chorioamniotic membranes and persist in amniotic fluid, which is nutritionally deplete and rich in fetal immunologic factors such as antimicrobial peptides. We used next-generation sequencing of transposon-genome junctions (Tn-seq) to identify five GBS genes that promote survival in the presence of human amniotic fluid. Read More

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A Narrative Review of the Molecular Epidemiology and Laboratory Surveillance of Vaccine Preventable Bacterial Meningitis Agents: , , and .

Microorganisms 2021 Feb 22;9(2). Epub 2021 Feb 22.

Laboratory for Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.

This narrative review describes the public health importance of four most common bacterial meningitis agents, , , , and (group B ). Three of them are strict human pathogens that normally colonize the nasopharynx and may invade the blood stream to cause systemic infections and meningitis. colonizes the genito-gastrointestinal tract and is an important meningitis agent in newborns, but also causes invasive infections in infants or adults. Read More

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February 2021

Invasive Bacterial Infections in Subjects with Genetic and Acquired Susceptibility and Impacts on Recommendations for Vaccination: A Narrative Review.

Microorganisms 2021 Feb 24;9(3). Epub 2021 Feb 24.

Institut Pasteur, Invasive Bacterial Infections Unit, 28 Rue du Dr. Roux, CEDEX 15, 75724 Paris, France.

The WHO recently endorsed an ambitious plan, "Defeating Meningitis by 2030", that aims to control/eradicate invasive bacterial infection epidemics by 2030. Vaccination is one of the pillars of this road map, with the goal to reduce the number of cases and deaths due to , , and . The risk of developing invasive bacterial infections (IBI) due to these bacterial species includes genetic and acquired factors that favor repeated and/or severe invasive infections. Read More

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February 2021

Ozone nanobubble modulates the innate defense system of Nile tilapia (Oreochromis niloticus) against Streptococcus agalactiae.

Fish Shellfish Immunol 2021 May 2;112:64-73. Epub 2021 Mar 2.

Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok, 10300, Thailand. Electronic address:

Ozone nanobubble (NB-O) is a promising technology for improving dissolved oxygen and reducing bacterial concentration in aquaculture systems. Here, we investigated the effects of NB-O on the innate immunity of fish by monitoring the expression levels of nonspecific immune-related genes (IL-1β, IL-2β, TNF-α), heat-shock protein genes (HSP70, HSP90-α), and a bacteriolytic enzyme, C-type lysozyme, gene (LYZ) post-treatment with this technology. Following exposure to NB-O, the different tissues of Nile tilapia (Oreochromis niloticus) were collected over time for quantitative real-time PCR (qPCR) analysis. Read More

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In-hospital mortality among patients with invasive non-group A β-hemolytic treated with clindamycin combination therapy: a nationwide cohort study.

Acute Med Surg 2021 Jan-Dec;8(1):e634. Epub 2021 Feb 19.

Department of Clinical Epidemiology and Health Economics School of Public Health The University of Tokyo Tokyo Japan.

Aim: Combination treatment with clindamycin is recommended in patients with invasive group A infection; however, whether the same treatment is effective in invasive group B and subspecies infections remains unknown. We aimed to investigate whether clindamycin added to standard of care therapy would be effective in patients with invasive non-group A β-hemolytic infections.

Methods: This was a nationwide retrospective cohort study using the Japanese Diagnosis Procedure Combination inpatient database focusing on the period between 2010 and 2018. Read More

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February 2021

BIOLOGICAL CHARACTERIZATION OF BACTERIOPHAGES AGAINST STREPTOCOCCUS AGALACTIAE.

Georgian Med News 2021 01(310):182-186

G. Eliava Institute of Bacteriophages, Microbiology and Virology

Streptococcus agalactiae, also known as group B streptococci, was first isolated from cow's milk with mastitis, and it was first identified in 1930 by Rebecca Lancefield. GBS or streptococcus agalacticae is a gram-positive cocci, beta-hemolytic, facultative anaerobic, which is a harmless inhabitant of the normal human microflora. About 30% of the population is an asymptomatic carrier of this microbe. Read More

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January 2021

Distinct Group B Sequence and Capsule Types Differentially Impact Macrophage Stress and Inflammatory Signaling Responses.

Infect Immun 2021 Apr 16;89(5). Epub 2021 Apr 16.

Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA

Group B (GBS) is an opportunistic bacterial pathogen that can contribute to the induction of preterm birth in colonized pregnant women and to severe neonatal disease. Many questions regarding the mechanisms that drive GBS-associated pathogenesis remain unanswered, and it is not yet clear why virulence has been observed to vary so extensively across GBS strains. Previously, we demonstrated that GBS strains of different sequence types (STs) and capsule (CPS) types induce different cytokine profiles in infected THP-1 macrophage-like cells. Read More

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Comparative study of culture, next-generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer.

J Orthop Res 2021 Feb 5. Epub 2021 Feb 5.

Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, New York, USA.

Treatment of deep musculoskeletal infection (MSKI) begins with accurate identification of the offending pathogen, surgical excision/debridement, and a course of culture-directed antibiotics. Despite this, the incidence of recurrent infection continues to rise. A major contributor to this is inaccurate or negative initial cultures. Read More

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February 2021

Draft Genome Sequence of Streptococcus agalactiae TA B490, a Multidrug-Resistant Strain Isolated from Bovine Mastitis in Argentina.

Microbiol Resour Announc 2021 Feb 4;10(5). Epub 2021 Feb 4.

Laboratorio de Inmunoquímica y Biotecnología, Centro de Investigación Veterinaria de Tandil, CONICET-CIC-UNCPBA, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina

is a bovine pathogen that causes intramammary infections. For humans, is a leading cause of neonatal death and an emerging pathogen in adults. Here, we present the draft genome sequence of TA B490, a multidrug-resistant strain isolated from bovine mastitis in Argentina. Read More

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February 2021

Analysis of virulence factors and antibiotic resistance genes in group B streptococcus from clinical samples.

BMC Infect Dis 2021 Jan 28;21(1):125. Epub 2021 Jan 28.

Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Room No. 3.22 Falmouth Building, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Background: Streptococcus agalacticae (Group B Streptococcus, GBS) is one of the most important causative agents of serious infections among neonates. This study was carried out to identify antibiotic resistance and virulence genes associated with GBS isolated from pregnant women.

Methods: A total of 43 GBS isolates were obtained from 420 vaginal samples collected from HIV positive and negative women who were 13-35 weeks pregnant attending Antenatal Care at Chitungwiza and Harare Central Hospitals in Zimbabwe. Read More

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January 2021

Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae.

Photochem Photobiol 2021 Jan 27. Epub 2021 Jan 27.

Department of Biomedical Engineering, Boston University, Boston, MA.

Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is increasingly recognized as a major cause of soft tissue and invasive diseases in the elderly and diabetic populations. Antibiotics like penicillin are used with great frequency to treat these infections, although antimicrobial resistance is increasing among GBS strains and underlines a need for alternative methods not reliant on traditional antibiotics. GBS granadaene pigment is related to the hemolysin/cytolysin of GBS, which is critical for the pathogenesis of GBS diseases. Read More

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January 2021

Application of the FTA elute card coupled with visual colorimetric loop-mediated isothermal amplification for the rapid diagnosis of Streptococcus agalactiae in farmed tilapia (Oreochromis niloticus).

J Fish Dis 2021 May 24;44(5):505-512. Epub 2021 Jan 24.

ISEM, CNRS, EPHE, IRD, Univ Montpellier, Montpellier, France.

A method combining the FTA Elute card and visual colorimetric loop-mediated isothermal amplification (FTA-e/LAMP) was tested to diagnose Streptococcus agalactiae infections in vitro and in vivo. FTA-e/LAMP consists of two main steps: first, the FTA card is used to extract DNA and then a colorimetric loop-mediated isothermal amplification (LAMP) reaction is carried out on the extracted DNA. In vitro sensitivity was 1. Read More

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Clinical Utility of Pourmedia ViGBS Agar Medium for Group B Screening.

Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2020 Dec;30(1):1-6

Department of Clinical Laboratory, Medical Diagnostic Center of URAWA Medical Association: 6-4-18 Tokiwa, Urawa-ku, Saitama 338-0011, Japan.

Group B (hereinafter GBS) is the main pathogen in neonatal sepsis and meningitis, accounting for approximately one quarter of the cases. 1) Prevention of infection is therefore crucial. The GBS carriage testing of pregnant women is necessary to prevent infections. Read More

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December 2020

Prevalence and Antimicrobial Susceptibility Profiles of Microorganisms Associated with Lower Reproductive Tract Infections in Women from Southern Poland-Retrospective Laboratory-Based Study.

Int J Environ Res Public Health 2021 01 5;18(1). Epub 2021 Jan 5.

Department of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland.

Objective: Female infections affecting the genital tract include sexually transmitted diseases, endogenous infections such as vulvovaginal candidiasis, bacterial vaginosis (BV) or aerobic vaginitis (AV) and healthcare-associated infections. The aim of the study was to analyze the etiological factors of the vaginal dysbacteriosis, and the antimicrobial susceptibility of the dominant bacterial and fungal infections in different age groups of outpatient women from the Silesian Region.

Materials And Methods: A retrospective laboratory-based multi-center study encompassed 4994 women of different ages in Silesian Voivodeship, in the south of Poland; patients who had vaginal swabs collected as per physicians' orders during the period from 1 January 2017 until 30 June 2018 were included in the study. Read More

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January 2021

Molecular Characterization of Hospital- and Community-Acquired Isolates among Nonpregnant Adults in Isfahan, Iran.

Adv Biomed Res 2020 30;9:44. Epub 2020 Sep 30.

Department of Bacteriology and Virology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The increasing incidence of Group B Streptococcus (GBS) infection among nonpregnant adults has become of growing clinical and public health concern. The current study investigated the distribution of important virulence determinants and antibiotic susceptibility of GBS isolates causing community acquired (CA) and hospital acquired (HA) infections among nonpregnant adults.

Materials And Methods: A total of 62 GBS, including 31 CA GBS and 31 HA GBS, were collected from a teaching hospital in Isfahan, Iran. Read More

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September 2020

Prevalence, serotypes and virulence genes of Streptococcus agalactiae isolated from pregnant women with 35-37 weeks of gestation.

BMC Infect Dis 2021 Jan 14;21(1):73. Epub 2021 Jan 14.

Facultad de Ciencias Exactas, Químicas y Naturales (FCEQyN), Departamento de Microbiología, Universidad Nacional de Misiones (UNaM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Posadas, Argentina.

Background: In pregnant women Streptococcus agalactiae (GBS) can be transmitted to newborn causing severe infections. It is classified into 10 serotypes (Ia, Ib, II-IX). The severity of neonatal disease is determined by the capsular serotype and virulence factors such as the polysaccharide capsule, encoded by the cps gene, protein C, which includes the Cα surface proteins (bca gene), Rib (rib gene) and Cβ (bac gene); the proteins Lmb (lmb gene), FbsB (fbsB gene), FbsA (fbsA gene), the cyl operon encoding a β-hemolysin (hylB gene), the CAMP factor (cfb gene) and the C5a peptidase (scpB gene). Read More

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January 2021