Array ( ) Array ( ) Array ( ) Array ( ) Array ( ) Array ( ) Array ( ) Array ( ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Array ( [29563166] => Array ( [impactFactor] => 14.630 [numCitations] => 3 ) ) Streeter Dysplasia Publications | PubFacts

785 results match your criteria Streeter Dysplasia


Outcome and complications in goats treated by perineal urethrostomy for obstructive urolithiasis: 25 cases (2010-2017).

J Vet Intern Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Sciences, Oklahoma State University, Stillwater, Oklahoma.

Background: Obstructive urolithiasis commonly affects male goats. Perineal urethrostomy (PU) can be a permanent treatment option but is generally considered undesirable because of the risk of stricture of the urethral stoma. Limited information exists regarding long-term outcome and complications in goats undergoing PU for treatment of obstructive urolithiasis. Read More

View Article
November 2018

A Bioprinted Cardiac Patch Composed of Cardiac-Specific Extracellular Matrix and Progenitor Cells for Heart Repair.

Adv Healthc Mater 2018 Dec 31;7(23):e1800672. Epub 2018 Oct 31.

Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr., Atlanta, GA, 30322, USA.

Congenital heart defects are present in 8 of 1000 newborns and palliative surgical therapy has increased survival. Despite improved outcomes, many children develop reduced cardiac function and heart failure requiring transplantation. Human cardiac progenitor cell (hCPC) therapy has potential to repair the pediatric myocardium through release of reparative factors, but therapy suffers from limited hCPC retention and functionality. Read More

View Article
December 2018
4 Reads

Surgical ligation of patent ductus arteriosus in a dorper sheep.

Vet Surg 2018 Oct 26. Epub 2018 Oct 26.

College of Veterinary Medicine, University of Illinois, Urbana, Illinois.

Objective: To report the diagnosis and treatment of a companion dorper wether with patent ductus arteriosus (PDA).

Study Design: Case report.

Animal: An 8-month-old dorper wether presented to its primary care veterinarian for a persistent cough and was referred for suspected heart failure on the basis of physical examination and thoracic radiography. Read More

View Article
October 2018
6 Reads

Disequilibrium, Adaptation, and the Norse Settlement of Greenland.

Hum Ecol Interdiscip J 2018 10;46(5):665-684. Epub 2018 Sep 10.

6School of Geography and Sustainable Development, Irvine Building, University of St Andrews, St Andrews, KY16 9AL UK.

There is increasing evidence to suggest that arctic cultures and ecosystems have followed non-linear responses to climate change. Norse Scandinavian farmers introduced agriculture to sub-arctic Greenland in the late tenth century, creating synanthropic landscapes and utilising seasonally abundant marine and terrestrial resources. Using a niche-construction framework and data from recent survey work, studies of diet, and regional-scale climate proxies we examine the potential mismatch between this imported agricultural niche and the constraints of the environment from the tenth to the fifteenth centuries. Read More

View Article
September 2018

Chromosome assembly of large and complex genomes using multiple references.

Genome Res 2018 11 19;28(11):1720-1732. Epub 2018 Oct 19.

BioTuring Incorporated, San Diego, California 92121, USA.

Despite the rapid development of sequencing technologies, the assembly of mammalian-scale genomes into complete chromosomes remains one of the most challenging problems in bioinformatics. To help address this difficulty, we developed Ragout 2, a reference-assisted assembly tool that works for large and complex genomes. By taking one or more target assemblies (generated from an NGS assembler) and one or multiple related reference genomes, Ragout 2 infers the evolutionary relationships between the genomes and builds the final assemblies using a genome rearrangement approach. Read More

View Article
November 2018

Trends in racial and ethnic demographics of the nursing workforce: 2000 to 2015.

Nurs Outlook 2018 Jul - Aug;66(4):365-371. Epub 2018 May 30.

National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD.

Background: The case for a more diverse nursing workforce has never been stronger given the rapidly changing demographics of the United States (U.S.) and the underrepresentation of certain racial and ethnic groups in nursing. Read More

View Article

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.

Proc Natl Acad Sci U S A 2018 09 27;115(37):9228-9233. Epub 2018 Aug 27.

A.B. Hancock Memorial Laboratory for Cancer Research, Vanderbilt University, Nashville, TN 37232;

Histone posttranslational modifications (PTMs) regulate chromatin dynamics, DNA accessibility, and transcription to expand the genetic code. Many of these PTMs are produced through cellular metabolism to offer both feedback and feedforward regulation. Herein we describe the existence of Lys and Arg modifications on histones by a glycolytic by-product, methylglyoxal (MGO). Read More

View Article
September 2018

Brief communication: Test of a method to identify double-zonal osteon in polarized light microscopy.

Am J Phys Anthropol 2018 Oct 22;167(2):407-415. Epub 2018 Aug 22.

Department of Anthropology, Boise State University, Boise, Idaho, 83725-1950.

Objectives: Double-zonal osteons (DZ) have been of interest in paleopathological research because they might be linked to physiological pathology. DZ are thought to be evidence of arrested osteon formation with a brief but abrupt increase in mineralization of lamellae occurring during bone remodeling. Originally identified from microradiographs as hypermineralized rings, recent studies have identified DZ from linear polarized light microscopy (PLM). Read More

View Article
October 2018

Joseph Resch and the plea of the practicing neurologists: A postwar neurology resident's tale.

J Hist Neurosci 2018 Jul-Sep;27(3):272-282

a American Academy of Neurology , Minneapolis , Minnesota , USA.

When University of Minnesota neurology resident Joseph A. Resch complained to the department director, A. B. Read More

View Article

Energy of the quasi-free electron in CO and HD: Probing intermolecular potentials within the local Wigner-Seitz model.

J Chem Phys 2018 Aug;149(6):064307

School of Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA.

We present the quasi-free electron energy () in the weakly polar fluids CO and HD from gas to liquid densities , on noncritical isotherms, and at a temperature near the critical isotherm. These results represent the first systematic investigation of () in polar fluids across a broad density range and illustrate that field enhanced photoemission can be used to obtain data in such systems. We show that the local Wigner-Seitz model for (), when coupled with thermodynamic data for the fluids, can yield optimized intermolecular potential parameters, as well as the magnitude of the zero kinetic energy electron scattering length. Read More

View Article
August 2018
1 Read

Apparent resolution of parrot bornavirus infection in cockatiels ().

Vet Med (Auckl) 2017 6;8:31-36. Epub 2017 Jul 6.

Schubot Exotic Bird Health Center, Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX,

Parrot bornavirus (PaBV), the etiologic agent of proventricular dilatation disease (PDD), is a major cause of concern in the avian health community. Within an infected flock, some birds will develop PDD and succumb to disease, while others remain healthy. Until now, there has been no study describing the results of long-term infection in apparently healthy carriers. Read More

View Article

Application of the 2015 proposed NIOSH vapor containment performance protocol for closed system transfer devices used during pharmacy compounding and administration of hazardous drugs.

J Oncol Pharm Pract 2018 Jul 24:1078155218787256. Epub 2018 Jul 24.

1 UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, USA.

Purpose The National Institute for Occupational Safety and Health (NIOSH) released a proposed protocol in 2015 to evaluate the vapor containment abilities of closed system transfer device technologies in order to provide meaningful comparisons between products. This study assessed the vapor containment ability of closed system transfer devices when following the methodology as outlined by the 2015 NIOSH proposed protocol. Methods This study evaluated six closed system transfer device brands following the draft NIOSH vapor containment protocol. Read More

View Article
July 2018
2 Reads

Distribution and mass of groundwater orthophosphorus in an agricultural watershed.

Sci Total Environ 2018 Jun 12;625:1330-1340. Epub 2018 Jan 12.

USDA Agricultural Research Service, National Laboratory for Agriculture and Environment, Ames, IA, United States.

Orthophosphorus (OP) is the form of dissolved inorganic P that is commonly measured in groundwater studies, but the spatial distribution of groundwater OP across a watershed has rarely been assessed. In this study, we characterized spatial patterns of groundwater OP concentrations and loading rates within the 5218ha Walnut Creek watershed (Iowa) over a two-year period. Using a network of 24 shallow (<6m) monitoring wells established across watershed, OP concentrations ranged from <0. Read More

View Article
June 2018
1 Read

Observation of Laser Power Amplification in a Self-Injecting Laser Wakefield Accelerator.

Phys Rev Lett 2018 Jun;120(25):254801

John Adams Institute for Accelerator Science, The Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.

We report on the depletion and power amplification of the driving laser pulse in a strongly driven laser wakefield accelerator. Simultaneous measurement of the transmitted pulse energy and temporal shape indicate an increase in peak power from 187±11  TW to a maximum of 318±12  TW after 13 mm of propagation in a plasma density of 0.9×10^{18}  cm^{-3}. Read More

View Article
June 2018
7 Reads

Preparation and Response to Truck Accidents on Highways Involving Cattle.

Vet Clin North Am Food Anim Pract 2018 Jul;34(2):289-307

Ridgeline Vet Services, LLC, 89493 509 Avenue, Lynch, NE 68746, USA.

Annually, in the United States, more than 50 million head of cattle are transported. Most are transported via semitrailer. As the number of livestock transported via motor vehicles has increased, so has the number of accidents involving livestock transport. Read More

View Article

Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations.

Cell Mol Gastroenterol Hepatol 2018 10;6(1):79-96. Epub 2018 Mar 10.

Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.

Background & Aims: Continual renewal of the intestinal epithelium is dependent on active- and slow-cycling stem cells that are confined to the crypt base. Tight regulation of these stem cell populations maintains homeostasis by balancing proliferation and differentiation to support critical intestinal functions. The hierarchical relation of discrete stem cell populations in homeostasis or during regenerative epithelial repair remains controversial. Read More

View Article
March 2018
9 Reads

Safety of dose-reduced pemetrexed in patients with renal insufficiency.

J Oncol Pharm Pract 2018 Jan 1:1078155218780507. Epub 2018 Jan 1.

3 Department of Medicine, Section of Hematology and Oncology at The James Cancer Hospital and Solove Research Institute at The Ohio State University, Columbus, USA.

Purpose Pemetrexed has been shown to be effective in the treatment of advanced and metastatic nonsquamous nonsmall cell lung cancer. In this population, renal insufficiency is common; however, pemetrexed is not recommended in patients with a creatinine clearance (CrCl) < 45 ml/min due to increased myelosuppression reported in phase I trials. The primary objective of this study is to determine the safety of dose-reduced pemetrexed in patients with a CrCl < 45 ml/min. Read More

View Article
January 2018
8 Reads

Closing Behavioral Health Workforce Gaps: A HRSA Program Expanding Direct Mental Health Service Access in Underserved Areas.

Am J Prev Med 2018 Jun;54(6S3):S190-S191

U.S. Department of Health and Human Services, Health Resources and Services Administration, National Center for Health Workforce Analysis, Rockville, Maryland.

View Article
June 2018
1 Read

Humanised recombinant antibody fragments bind human pancreatic islet cells.

J Immunol Methods 2018 Aug 21;459:20-28. Epub 2018 May 21.

Department of Pediatrics, Pape' Family Pediatric Research Institute, Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR, USA.

We describe here the humanisation of two mouse monoclonal antibodies that bind to surface markers on human pancreatic islet endocrine cells. Monoclonal antibodies produced by the HIC1-2B4 and HIC0-4F9 mouse hybridomas bind distinct surface molecules expressed on endocrine cells and have been validated for a number of experimental methods including immunohistochemistry and live cell sorting by flow cytometry. Variable region framework and first constant region domain sequences were replaced with that from compatible human antibody sequences, and the resulting recombinant antigen-binding fragments were cloned and expressed in mouse myeloma cells. Read More

View Article
August 2018
1 Read

Subsurface nutrient processing capacity in agricultural roadside ditches.

Sci Total Environ 2018 Oct 10;637-638:470-479. Epub 2018 May 10.

Tallgrass Prairie Center, University of Northern Iowa, Cedar Falls, IA, United States.

Roadside ditches located throughout urban and rural landscapes are integral components of watershed-scale hydrologic processes but their capacity to reduce nutrients in the subsurface environment has not been investigated. In this study, vegetation, soil and groundwater conditions were characterized in six roadside ditches in the 66 km Lime Creek watershed in eastern Iowa. Shallow water table wells were installed at 17 locations in six transects and sampled monthly in 2017 to evaluate spatial and temporal patterns. Read More

View Article
October 2018
7 Reads

Repeat associated mechanisms of genome evolution and function revealed by the and genomes.

Genome Res 2018 04 21;28(4):448-459. Epub 2018 Mar 21.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.

Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-level assemblies of the and genomes. Together with the and genomes, this set of rodent genomes is similar in divergence times to the Hominidae (human-chimpanzee-gorilla-orangutan). Read More

View Article
April 2018
11 Reads
3 PubMed Central Citations(source)
14.630 Impact Factor

Enhanced Laser-Driven Ion Acceleration by Superponderomotive Electrons Generated from Near-Critical-Density Plasma.

Phys Rev Lett 2018 Feb;120(7):074801

Fakultät für Physik, Ludwig-Maximilians-Universität München, D-85748 Garching, Germany.

We report on the experimental studies of laser driven ion acceleration from a double-layer target where a near-critical density target with a few-micron thickness is coated in front of a nanometer-thin diamondlike carbon foil. A significant enhancement of proton maximum energies from 12 to ∼30  MeV is observed when a relativistic laser pulse impinges on the double-layer target under linear polarization. We attributed the enhanced acceleration to superponderomotive electrons that were simultaneously measured in the experiments with energies far beyond the free-electron ponderomotive limit. Read More

View Article
February 2018

Convergent genomic signatures of domestication in sheep and goats.

Nat Commun 2018 03 6;9(1):813. Epub 2018 Mar 6.

Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.

The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence the genomes of wild Asiatic mouflon and Bezoar ibex in the sheep and goat domestication center and compare their genomes with that of domestics from local, traditional, and improved breeds. Read More

View Article
March 2018
29 Reads

Retrospective evaluation of plasma cholesterol concentration in septic dogs and its association with morbidity and mortality: 51 cases (2005-2015).

J Vet Emerg Crit Care (San Antonio) 2018 Mar 28;28(2):149-156. Epub 2018 Feb 28.

Department of Statistics and Actuarial Science, The University of Iowa, Iowa City, IA.

Objective: To determine whether plasma cholesterol concentrations in dogs with sepsis is associated with morbidity or in-hospital mortality.

Design: Retrospective cohort study from 2005-2015.

Setting: Two private referral centers. Read More

View Article

The effects of nutrient restriction on mRNA expression of endogenous retroviruses, interferon-tau, and pregnancy-specific protein-B during the establishment of pregnancy in beef heifers.

J Anim Sci 2018 Apr;96(3):950-963

Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND.

We hypothesize that syncytin-Rum1, bovine endogenous retrovirus-K1 (BERV-K1), pregnancy-specific protein-B (PSP-B), and interferon-τ (IFN-τ) will be influenced by maternal nutrient restriction and be differentially expressed during key stages (day 16, 34, and 50) of the establishment of gestation when fed to meet industry standards. Commercial crossbred heifers (n = 49) were maintained on a total mixed ration and supplemented with dried distillers grains with solubles. All heifers were subjected to 5-d CO-Synch + CIDR estrus synchronization protocol. Read More

View Article
April 2018
4 Reads

A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells.

Stem Cell Reports 2018 Jan;10(1):1-6

Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China.

Unambiguous cell line authentication is essential to avoid loss of association between data and cells. The risk for loss of references increases with the rapidity that new human pluripotent stem cell (hPSC) lines are generated, exchanged, and implemented. Ideally, a single name should be used as a generally applied reference for each cell line to access and unify cell-related information across publications, cell banks, cell registries, and databases and to ensure scientific reproducibility. Read More

View Article
January 2018
10 Reads

Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial.

Lancet Child Adolesc Health 2018 01;2(1):35-45

Institute of Health Research, University of Exeter Medical School, University of Exeter, Exeter, UK.

Background: Although childhood overweight and obesity prevalence has increased substantially worldwide in the past three decades, scarce evidence exists for effective preventive strategies. We aimed to establish whether a school-based intervention for children aged 9-10 years would prevent excessive weight gain after 24 months.

Methods: This pragmatic cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP), a school-based obesity prevention intervention, was done in 32 schools in southwest England. Read More

View Article
January 2018
7 Reads

Evaluating the Performance of a Visually Guided Hearing Aid Using a Dynamic Auditory-Visual Word Congruence Task.

Ear Hear 2018 Jul/Aug;39(4):756-769

From the Department of Speech, Language & Hearing Sciences, Boston University, Boston, MA.

Objectives: The "visually guided hearing aid" (VGHA), consisting of a beamforming microphone array steered by eye gaze, is an experimental device being tested for effectiveness in laboratory settings. Previous studies have found that beamforming without visual steering can provide significant benefits (relative to natural binaural listening) for speech identification in spatialized speech or noise maskers when sound sources are fixed in location. The aim of the present study was to evaluate the performance of the VGHA in listening conditions in which target speech could switch locations unpredictably, requiring visual steering of the beamforming. Read More

View Article
July 2019
8 Reads

Treatment of Major Depressive Disorder with Iyengar Yoga and Coherent Breathing: A Randomized Controlled Dosing Study.

Altern Complement Ther 2017 Dec;23(6):236-243

The aims of this study were to assess the effects of an intervention of Iyengar yoga and coherent breathing at five breaths per minute on depressive symptoms and to determine optimal intervention yoga dosing for future studies in individuals with major depressive disorder (MDD). Subjects were randomized to the high-dose group (HDG) or low-dose group (LDG) for a 12-week intervention of three or two intervention classes per week, respectively. Eligible subjects were 18-64 years old with MDD, had baseline Beck Depression Inventory-II (BDI-II) scores ≥14, and were either on no antidepressant medications or on a stable dose of antidepressants for ≥3 months. Read More

View Article
December 2017
7 Reads

Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.

Respir Physiol Neurobiol 2018 10 29;256:4-14. Epub 2017 Nov 29.

University of Florida, College of Public Health and Health Professions, McKnight Brain Institute, Department of Physical Therapy, PO Box 100154, 100 S. Newell Dr, Gainesville, FL 32610, United States; Center for Respiratory Research and Rehabilitation, University of Florida, Gainesville, FL 32610, United States. Electronic address:

Hypoxia elicits complex cell signaling mechanisms in the respiratory control system that can produce long-lasting changes in respiratory motor output. In this article, we review experimental approaches used to elucidate signaling pathways associated with hypoxia, and summarize current hypotheses regarding the intracellular signaling pathways evoked by intermittent exposure to hypoxia. We review data showing that pharmacological treatments can enhance neuroplastic responses to hypoxia. Read More

View Article
October 2018
1 Read

Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.

Am J Physiol Renal Physiol 2018 Apr 29;314(4):F501-F516. Epub 2017 Nov 29.

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center , Dallas, Texas.

The erythropoietin receptor (EpoR) is widely expressed but its renoprotective action is unexplored. To examine the role of EpoR in vivo in the kidney, we induced acute kidney injury (AKI) by ischemia-reperfusion in mice with different EpoR bioactivities in the kidney. EpoR bioactivity was reduced by knockin of wild-type human EpoR, which is hypofunctional relative to murine EpoR, and a renal tubule-specific EpoR knockout. Read More

View Article
April 2018
12 Reads

Nurse Handoff Communication.

Semin Oncol Nurs 2017 12 26;33(5):536-543. Epub 2017 Oct 26.

Objective: To describe the communication behaviors identified by nurses as key to a competent patient handoff at change of shift.

Data Sources: Qualitative analysis of nurse descriptions of best and worst handoffs from the incoming and outgoing nursing perspective.

Conclusion: Competent, quality nursing handoffs include specific information exchange and socioemotional (relational) communication behaviors. Read More

View Article
December 2017
9 Reads

Stochastic calculus analysis of optical time-of-flight range imaging and estimation of radial motion.

Authors:
Lee Streeter

J Opt Soc Am A Opt Image Sci Vis 2017 Jul;34(7):1063-1072

Time-of-flight range imaging is analyzed using stochastic calculus. Through a series of interpretations and simplifications, the stochastic model leads to two methods for estimating linear radial velocity: maximum likelihood estimation on the transition probability distribution between measurements, and a new method based on analyzing the measured correlation waveform and its first derivative. The methods are tested in a simulated motion experiment from (-40)-(+40)  m/s, with data from a camera imaging an object on a translation stage. Read More

View Article

Antibacterial Properties of Flavonoids from Kino of the Eucalypt Tree, Corymbia torelliana.

Plants (Basel) 2017 Sep 14;6(3). Epub 2017 Sep 14.

Centre for Genetics, Ecology and Physiology, University of the Sunshine Coast, Maroochydore DC, QLD 4558, Australia.

Traditional medicine and ecological cues can both help to reveal bioactive natural compounds. Indigenous Australians have long used kino from trunks of the eucalypt tree, , in traditional medicine. A closely related eucalypt, , produces a fruit resin with antimicrobial properties that is highly attractive to stingless bees. Read More

View Article
September 2017
10 Reads

Assessing the Needs of Parents of Children Diagnosed With Cancer in China: A Psychometric Study Developing a Needs Assessment Tool.

J Pediatr Oncol Nurs 2018 Jan/Feb;35(1):6-15. Epub 2017 Aug 29.

1 Shanghai Children's Medical Center, Shanghai, China.

The psychosocial well-being of parents remains integral to the treatment and recovery of children diagnosed with cancer. However, limited research addresses the unique needs of this population. To better understand the supportive care needs of parents of children with cancer, this study tested the reliability and stability of the factorial structure of a revised version of the Cancer Patient Needs Questionnaire (rCPNQ) with Chinese parents of children who have cancer. Read More

View Article
June 2018
10 Reads

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.

Nat Commun 2017 08 24;8(1):331. Epub 2017 Aug 24.

Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, M5G 1L7.

PDX1/NKX6-1 pancreatic progenitors (PPs) give rise to endocrine cells both in vitro and in vivo. This cell population can be successfully differentiated from human pluripotent stem cells (hPSCs) and hold the potential to generate an unlimited supply of β cells for diabetes treatment. However, the efficiency of PP generation in vitro is highly variable, negatively impacting reproducibility and validation of in vitro and in vivo studies, and consequently, translation to the clinic. Read More

View Article
August 2017
51 Reads

Anatomy and physiology of phrenic afferent neurons.

J Neurophysiol 2017 12 23;118(6):2975-2990. Epub 2017 Aug 23.

Department of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida;

Large-diameter myelinated phrenic afferents discharge in phase with diaphragm contraction, and smaller diameter fibers discharge across the respiratory cycle. In this article, we review the phrenic afferent literature and highlight areas in need of further study. We conclude that ) activation of both myelinated and nonmyelinated phrenic sensory afferents can influence respiratory motor output on a breath-by-breath basis; ) the relative impact of phrenic afferents substantially increases with diaphragm work and fatigue; ) activation of phrenic afferents has a powerful impact on sympathetic motor outflow, and ) phrenic afferents contribute to diaphragm somatosensation and the conscious perception of breathing. Read More

View Article
December 2017
20 Reads

Oxygen uptake prediction in rivers and streams: A stochastic approach.

J Environ Manage 2017 Dec 4;203(Pt 1):200-207. Epub 2017 Aug 4.

Dept. of Civil, Environmental and Geo-Engineering and St. Anthony Falls Laboratory, Univ. of Minnesota, Minneapolis, MN 55414, USA. Electronic address:

Dissolved oxygen fluctuations in a river over a short period of time were assumed to be caused by the microbial growth dynamics, and a stochastic model was built for oxygen uptake. As a case study, biochemical oxygen demand (BOD) was measured in water from the Ura River, Oita River, and Otozu River flowing through the urban district of Oita, Japan. Water samples were taken from each river and partitioned into BOD bottles. Read More

View Article
December 2017

The Benefit of a Visually Guided Beamformer in a Dynamic Speech Task.

Trends Hear 2017 Jan-Dec;21:2331216517722304

1 Department of Speech, Language and Hearing Sciences, Boston University, MA, USA.

The aim of this study was to evaluate the performance of a visually guided hearing aid (VGHA) under conditions designed to capture some aspects of "real-world" communication settings. The VGHA uses eye gaze to steer the acoustic look direction of a highly directional beamforming microphone array. Although the VGHA has been shown to enhance speech intelligibility for fixed-location, frontal targets, it is currently not known whether these benefits persist in the face of frequent changes in location of the target talker that are typical of conversational turn-taking. Read More

View Article
August 2017
14 Reads

Intermittent Hypoxia Enhances Functional Connectivity of Midcervical Spinal Interneurons.

J Neurosci 2017 Aug 27;37(35):8349-8362. Epub 2017 Jul 27.

Departments of Physical Therapy,

Brief, intermittent oxygen reductions [acute intermittent hypoxia (AIH)] evokes spinal plasticity. Models of AIH-induced neuroplasticity have focused on motoneurons; however, most midcervical interneurons (C-INs) also respond to hypoxia. We hypothesized that AIH would alter the functional connectivity between C-INs and induce persistent changes in discharge. Read More

View Article
August 2017
2 Reads

High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.

J Neurophysiol 2017 Oct 14;118(4):2344-2357. Epub 2017 Jun 14.

McKnight Brain Institute, Department of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida.

C2 spinal hemilesion (C2Hx) paralyzes the ipsilateral diaphragm, but recovery is possible through activation of "crossed spinal" synaptic inputs to ipsilateral phrenic motoneurons. We tested the hypothesis that high-frequency epidural stimulation (HF-ES) would potentiate ipsilateral phrenic output after subacute and chronic C2Hx. HF-ES (300 Hz) was applied to the ventrolateral C4 or T2 spinal cord ipsilateral to C2Hx in anesthetized and mechanically ventilated adult rats. Read More

View Article
October 2017
3 Reads

Alignment of 1000 Genomes Project reads to reference assembly GRCh38.

Gigascience 2017 07;6(7):1-8

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

The 1000 Genomes Project produced more than 100 trillion basepairs of short read sequence from more than 2600 samples in 26 populations over a period of five years. In its final phase, the project released over 85 million genotyped and phased variants on human reference genome assembly GRCh37. An updated reference assembly, GRCh38, was released in late 2013, but there was insufficient time for the final phase of the project analysis to change to the new assembly. Read More

View Article
July 2017
14 Reads

Precision Medicine: Genomic Profiles to Individualize Therapy.

Otolaryngol Clin North Am 2017 Aug 17;50(4):765-773. Epub 2017 May 17.

Healthcare Solutions, Oracle Corporation, 5805 Owens Drive, Pleasanton, CA 94588, USA.

Precision medicine is the application of genotypic and Omics biomarkers to determine the most appropriate, outcome-driven therapy for individual patients. To determine the best choice of therapy, institutions use significant information technology-enabled data from imaging, electronic medical records, sensors in the clinic/hospitals, and wearable sensors to determine treatment response. With genomic profiling, targets to affect a disease course are continuing to be developed. Read More

View Article
August 2017
16 Reads

MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation.

PLoS One 2017 11;12(5):e0177661. Epub 2017 May 11.

Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, United States of America.

Neurogenesis is a highly-regulated process occurring in the dentate gyrus that has been linked to learning, memory, and antidepressant efficacy. MicroRNAs (miRNAs) have been previously shown to play an important role in the regulation of neuronal development and neurogenesis in the dentate gyrus via modulation of gene expression. However, this mode of regulation is both incompletely described in the literature thus far and highly multifactorial. Read More

View Article
September 2017
9 Reads

Common genetic variation drives molecular heterogeneity in human iPSCs.

Nature 2017 06 10;546(7658):370-375. Epub 2017 May 10.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease. However, variable genetic and phenotypic characterization of many existing iPS cell lines limits their potential use for research and therapy. Here we describe the systematic generation, genotyping and phenotyping of 711 iPS cell lines derived from 301 healthy individuals by the Human Induced Pluripotent Stem Cells Initiative. Read More

View Article
June 2017
27 Reads

Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review.

J Clin Epidemiol 2017 Jul 28;87:23-34. Epub 2017 Apr 28.

Health Statistics Group, Institute of Health Research, University of Exeter Medical School, University of Exeter, St. Luke's Campus, Exeter EX1 2LU, United Kingdom. Electronic address:

Objectives: Motivated by recent calls to use electronic health records for research, we reviewed the application and development of methods for addressing the bias from unmeasured confounding in longitudinal data.

Study Design And Setting: Methodological review of existing literature. We searched MEDLINE and EMBASE for articles addressing the threat to causal inference from unmeasured confounding in nonrandomized longitudinal health data through quasi-experimental analysis. Read More

View Article
July 2017
10 Reads