559,007 results match your criteria Strategies for Studying Brain Disorders[Journal]


Language Specificity in Phonetic Cue Weighting: Monolingual and Bilingual Perception of the Stop Voicing Contrast in English and Spanish.

Phonetica 2019 Apr 24:1-23. Epub 2019 Apr 24.

Department of Speech, Language and Hearing Sciences, University of Florida, Gainesville, Florida, USA.

Background/aims: This work examines the perception of the stop voicing contrast in Spanish and English along four acoustic dimensions, comparing monolingual and bilingual listeners. Our primary goals are to test the extent to which cue-weighting strategies are language-specific in monolinguals, and whether this language specificity extends to bilingual listeners.

Methods: Participants categorized sounds varying in voice onset time (VOT, the primary cue to the contrast) and three secondary cues: fundamental frequency at vowel onset, first formant (F1) onset frequency, and stop closure duration. Read More

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http://dx.doi.org/10.1159/000497278DOI Listing

Biomechanically driven intraoperative spine registration during navigated anterior vertebral body tethering.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Ecole Polytechnique de Montreal, Montreal, CANADA.

The integration of pre-operative biomechanical planning with intra-operative imaging for navigated corrective spine surgery may improve surgical outcome, as well as the accuracy and safety of manoeuvres such as pedicle screw insertion and cable tethering, as these steps are performed empirically by the surgeon. However, registration of finite element models (FEM) of the spine remains challenging due to changes in patient positioning and imaging modalities. The purpose of this study was to develop and validate a new method registering a preoperatively constructed patient-specific finite element model (FEM) aimed to plan and assist anterior vertebral body tethering (AVBT) of scoliotic patients, to intraoperative Cone Beam Computed Tomography (CBCT) during navigated AVBT procedures. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1bfa
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http://dx.doi.org/10.1088/1361-6560/ab1bfaDOI Listing
April 2019
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Testosterone inhibits aneurysm formation and vascular inflammation in male mice.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

M Akishita, Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.

Abdominal aortic aneurysm (AAA), one of the pathological phenotypes of vascular aging, is characterized by aortic dilation with impaired arterial wall integrity. Recent epidemiologic studies have shown that men with AAA have lower serum testosterone (T) compared to men without. However, the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1530/JOE-18-0646DOI Listing

Associations between self-generated strategy use and MET-Home performance in adults with stroke.

Neuropsychol Rehabil 2019 Apr 24:1-15. Epub 2019 Apr 24.

e School of Occupational Therapy , Texas Woman's University , Dallas , TX , USA.

Self-generated strategy use has substantial potential for improving community living outcomes in adults with impaired executive function after stroke. However, little is known about how self-generated strategies support task performance in people with post-stroke executive function impairments living in the community. We explored strategy use among home-dwelling persons with stroke and neurologically-healthy control participants during the Multiple Errands Test-Home Version (MET-Home), a context-specific assessment with evidence of ecological validity designed to examine how post-stroke executive dysfunction manifests during task performance in the home environment. Read More

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http://dx.doi.org/10.1080/09602011.2019.1601112DOI Listing

Create Nanoscale Patterns with DNA Origami.

Small 2019 Apr 24:e1805554. Epub 2019 Apr 24.

Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Structural deoxyribonucleic acid (DNA) nanotechnology offers a robust platform for diverse nanoscale shapes that can be used in various applications. Among a wide variety of DNA assembly strategies, DNA origami is the most robust one in constructing custom nanoshapes and exquisite patterns. In this account, the static structural and functional patterns assembled on DNA origami are reviewed, as well as the reconfigurable assembled architectures regulated through dynamic DNA nanotechnology. Read More

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http://dx.doi.org/10.1002/smll.201805554DOI Listing

The relationship between motivations for cannabis consumption and problematic use.

Adicciones 2019 Apr 8;0(0):1221. Epub 2019 Apr 8.

Grup de Recerca en Addiccions Clínic (GRAC-GRE). Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS Hospital Clínic i Universitari de Barcelona. Universitat de Barcelona). Barcelona.

Introduction: Systematic screening of problematic cannabis use does not include the motivations that lead to consumption, although from a person-centered perspective this is fundamental. The present study explores the motivations for cannabis use in adults and its relationship with cannabis use patterns and problematic use.

Method: Adult cannabis users (previous 60 days) were recruited in the province of Barcelona (n = 468). Read More

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http://dx.doi.org/10.20882/adicciones.1221DOI Listing

Gender differences among cannabis self-cultivators in Spain.

Adicciones 2019 Mar 28;0(0):1142. Epub 2019 Mar 28.

Unidad de Psicología Forense. Universidade de Santiago de Compostela.

The increase in cannabis use coincides with the proliferation of small-scale cannabis cultivation. These crops facilitate substance availability and increased use. Some investigations have studied the characteristics of small-scale cultivators; however, it is not known whether their profiles differ by gender. Read More

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http://dx.doi.org/10.20882/adicciones.1142DOI Listing

Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level.

PLoS Pathog 2019 Apr 24;15(4):e1007708. Epub 2019 Apr 24.

Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.

Infection by large dsDNA viruses can lead to a profound alteration of host transcriptome and metabolome in order to provide essential building blocks to support the high metabolic demand for viral assembly and egress. Host response to viral infection can typically lead to diverse phenotypic outcome that include shift in host life cycle and activation of anti-viral defense response. Nevertheless, there is a major bottleneck to discern between viral hijacking strategies and host defense responses when averaging bulk population response. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007708
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http://dx.doi.org/10.1371/journal.ppat.1007708DOI Listing
April 2019
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Are we restoring functional fens? - The outcomes of restoration projects in fens re-analysed with plant functional traits.

PLoS One 2019 24;14(4):e0215645. Epub 2019 Apr 24.

Department of Plant Ecology & Environmental Conservation, Institute of Botany, Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland.

In peatland restoration we often lack an information whether re-established ecosystems are functionally similar to non-degraded ones. We re-analysed the long-term outcomes of restoration on vegetation and plant functional traits in 38 European fens restored by rewetting (18 sites) and topsoil removal (20 sites). We used traits related to nutrient acquisition strategies, competitiveness, seed traits, and used single- and multi-trait metrics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215645PLOS

The lab management practices of "Research Exemplars" that foster research rigor and regulatory compliance: A qualitative study of successful principal investigators.

PLoS One 2019 24;14(4):e0214595. Epub 2019 Apr 24.

Division of General Medical Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Introduction: Conducting rigorous scientific inquiry within the bounds of research regulation and acceptable practice requires a principal investigator to lead and manage research processes and personnel. This study explores the practices used by investigators nominated as exemplars of research excellence and integrity to produce rigorous, reproducible research and comply with research regulations.

Methods: Using a qualitative research design, we interviewed 52 principal investigators working in the United States at top research universities and the National Institutes of Health Intramural Research Program. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214595PLOS

Perceived water insecurity among adults from urban and peri-urban Haiti: A qualitative study.

PLoS One 2019 24;14(4):e0214790. Epub 2019 Apr 24.

Department of Anthropology University of Florida, Gainesville, FL, United States of America.

Water and sanitation services are fundamental in preventing the spread of waterborne and hygiene-related diseases. However, in developing countries, such as Haiti, access to clean water continues to pose major challenges despite efforts to improve quality and reduce distance. With Léogâne being the epicenter of the earthquake in Haiti in 2010, there were dozens of interventions aimed to improve access to clean water, specifically well construction and use of water treatment strategies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214790PLOS

Infection mechanisms and putative effector repertoire of the mosquito pathogenic oomycete Pythium guiyangense uncovered by genomic analysis.

PLoS Genet 2019 Apr 24;15(4):e1008116. Epub 2019 Apr 24.

College of Plant Protection, Nanjing Agricultural University, Nanjing, China.

Pythium guiyangense, an oomycete from a genus of mostly plant pathogens, is an effective biological control agent that has wide potential to manage diverse mosquitoes. However, its mosquito-killing mechanisms are almost unknown. In this study, we observed that P. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008116DOI Listing

Long-term fish assemblages of the Ohio River: Altered trophic and life history strategies with hydrologic alterations and land use modifications.

PLoS One 2019 24;14(4):e0211848. Epub 2019 Apr 24.

Department of Biology, Ball State University, Muncie, Indiana, United States of America.

Long-term monitoring of species assemblages provides a unique opportunity to test hypotheses regarding environmentally induced directional trajectories of freshwater species assemblages. We used 57 years of lockchamber fish rotenone and boat electrofishing survey data (1957-2014) collected by the Ohio River Valley Water Sanitation Commission (ORSANCO) to test for directional trajectories in taxonomy, trophic classifications, and life history strategies of freshwater fish assemblages in the Ohio River Basin. We found significant changes in taxonomic and trophic composition of freshwater fishes in the Ohio River Basin. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211848PLOS

Analysis of States' Barriers to and Progress Toward Implementation of Health and Safety Policies for Secondary School Athletics.

J Athl Train 2019 Apr 24. Epub 2019 Apr 24.

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs.

Context: Implementation of health and safety best practices for the leading causes of sudden death and catastrophic injury has been shown to mitigate risk. However, to our knowledge, no authors have examined progress toward health and safety policy implementation at the state level.

Objective: To investigate the progress made by state secondary school leaders in developing and implementing health and safety policies (ie, exertional heat stroke, sudden cardiac arrest, concussion, emergency action plans) and to explore perceived barriers to and strategies for implementation. Read More

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http://dx.doi.org/10.4085/1062-6050-28-18DOI Listing

Synthesis, Crystal Structures, and Photochemical Properties of a Family of Heterometallic Titanium Oxo Clusters.

Inorg Chem 2019 Apr 24. Epub 2019 Apr 24.

State Key Laboratory of Rare Earth Resource Utilization , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street , Changchun , Jilin 130022 , China.

The incorporation of heterometallic atoms into the structure of titanium-oxygen nanomaterials is one of the known and effective strategies to develop new high-performance photovoltaic active materials. In this study, we have synthesized three benzoic acid-stabilized heterometallic titanium oxo clusters with the different transition metals Co, Cu, and Cd, formulated as [TiCo(μ-O)(μ-O)(CHCOO)(CHCN)]·2CHCN (1), [TiCu(μ-O)(CHCOO)] (2), and [TiCd(μ-O)(μ-O)(μ-O)(CHCOO)(CHCOOH)(CHCN)]·CHCN·CHCOOH (3), and then we characterized their structures. UV-vis spectroscopy analysis revealed an enhanced UV-vis-light absorption of those heterometallic clusters. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00508DOI Listing

Behavior of the Chiral Herbicide Imazamox in Soils: Enantiomer Composition Differentiates Between Biodegradation and Photodegradation.

Environ Sci Technol 2019 Apr 24. Epub 2019 Apr 24.

Imazamox is a chiral herbicide that, in laboratory experiments in the dark, exhibits pronounced enantioselective biodegradation in certain soils. Imazamox also shows rapid photodegradation. However, which processes are predominant in the field, is not clear. Read More

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http://pubs.acs.org/doi/10.1021/acs.est.8b07210
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http://dx.doi.org/10.1021/acs.est.8b07210DOI Listing
April 2019
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Hepatitis B core antigen can regulate NLRP3 inflammasome pathway in HepG2 cells.

J Med Virol 2019 Apr 24. Epub 2019 Apr 24.

Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatitis B virus(HBV) has four open reading frames (ORFs) of which ORF C is consists of the pre Core and Core genes encodes the Hepatitis B core antigen (HBcAg) and Hepatitis B e antigen (HBeAg). Studies have shown that HBeAg significantly inhibits the NLRP3 inflammasome activation and IL-1β production. However, the role of HBcAg and ORF C proteins (in this paper, ORF C proteins = HBcAg + HBeAg) were remain unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25490
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http://dx.doi.org/10.1002/jmv.25490DOI Listing
April 2019
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Synthetic strategies for fluorination of carbohydrates.

Org Biomol Chem 2019 Apr 24. Epub 2019 Apr 24.

Departmento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 954 CP1113-Buenos Aires, Argentina.

This review article discusses different synthetic strategies for accomplishing regio- and stereoselective fluorinations of the sugar moiety, discussing the reaction mechanisms and some biological implications arising from such substitutions. Read More

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http://dx.doi.org/10.1039/c9ob00405jDOI Listing

Serum C-reactive protein relationship in high- versus low-virulence pathogens in the diagnosis of periprosthetic joint infection.

J Med Microbiol 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Holstenstrasse 2, 22767 Hamburg, Germany.

Little is known about the relationship between the virulence of pathogens in periprosthetic joint infection (PJI) and C-reactive protein (CRP) levels. In this context, we assessed the performance of CRP for PJI. We collected the following data from 987 cases of total joint revision due to PJI and 386 cases of aseptic revision: age, gender, comorbidities, values for serum CRP, leukocytes, microbiology for preoperatively taken aspirations and at least 2 intraoperative biopsies, and presence or absence of a draining sinus. Read More

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http://dx.doi.org/10.1099/jmm.0.000958DOI Listing

Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).

Int J Vitam Nutr Res 2019 Apr 24:1-10. Epub 2019 Apr 24.

6 Associate professor of Radiology, Faculty of paramedical, Tabriz University of Medical Sciences, Tabriz, Iran.

In an attempt to investigate new strategies aimed at reducing risk factors of non-alcoholic fatty liver disease (NAFLD), effects of turmeric (Curcuma longa L.) and chicory seed (Cichorium intybus L.) supplementation was evaluated in these patients. Read More

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http://dx.doi.org/10.1024/0300-9831/a000568DOI Listing

Case Study: Cognitive Restructuring Hypnosis for Chronic Pain in a Quadriplegic Patient.

Am J Clin Hypn 2019 Apr;61(4):394-408

b University of Washington , Seattle , Washington , USA.

This case study reports on a 28-year-old male with spinal cord injury (SCI), quadriplegia, and chronic pain with neuropathic characteristics. The treatment had to be adapted to address the patient's needs, as he was on a respirator and paralyzed from the chin down. The intervention consisted of eight 90-minute sessions. Read More

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http://dx.doi.org/10.1080/00029157.2018.1537973DOI Listing

Strategies and Design of Hypnosis Intervention for Tobacco Cessation.

Authors:
Mary Herring

Am J Clin Hypn 2019 Apr;61(4):345-369

a Healing Interventions, PC.

The purpose of this article is to share approaches and program design to assist healthcare professionals trained in hypnosis help tobacco users become tobacco free. Helping tobacco users overcome their tobacco dependency is generally seen as challenging to healthcare professionals. Efforts to stop a tobacco habit have components which are both physical and emotional in nature and which produce periods of discomfort and high relapse rates. Read More

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http://dx.doi.org/10.1080/00029157.2018.1491386DOI Listing
April 2019
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Drug use beyond the licence in palliative care: A systematic review and narrative synthesis.

Palliat Med 2019 Apr 24:269216319840602. Epub 2019 Apr 24.

Department of Palliative Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

Background: Drug use beyond the licence (off-label use, off-label drug use) is a common practice in palliative care and respective recommendations can often be identified in the literature. It is both risky and offers opportunities at the same time and, therefore, requires special attention in clinical practice.

Aim: To determine the prevalence of off-label drug use in palliative care and to identify, evaluate and critically appraise studies describing the clinical practice, healthcare professionals' awareness, knowledge and attitudes towards off-label-use and management strategies. Read More

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http://dx.doi.org/10.1177/0269216319840602DOI Listing

Enhanced production of recombinant Staphylococcus simulans lysostaphin using medium engineering.

Prep Biochem Biotechnol 2019 Apr 24:1-8. Epub 2019 Apr 24.

e Department of Bioengineering , Gebze Technical University , Gebze , Kocaeli , Turkey.

Staphylococcus aureus, among other staphylococcal species, developed multidrug resistance and causes serious health risks that require complex treatments. Therefore, the development of novel and effective strategies to combat these bacteria has been gaining importance. Since Staphylococcus simulans lysostaphin is a peptidoglycan hydrolase effective against staphylococcal species, the enzyme has a significant potential for biotechnological applications. Read More

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http://dx.doi.org/10.1080/10826068.2019.1599393DOI Listing

Challenges For Middle-Income Elders In An Aging Society.

Authors:
John W Rowe

Health Aff (Millwood) 2019 Apr 24:101377hlthaff201900095. Epub 2019 Apr 24.

John W. Rowe ( ) is a professor in the Department of Health Policy and Management, Mailman School of Public Health, Columbia University, in New York City.

The United States is becoming an "aging society," in which the number of people older than age sixty exceeds the number of those younger than age fifteen. This transformation has major implications for many aspects of American life. The fundamental challenge relates to our core societal institutions-education, work and retirement, health care, housing, and the like-which were not designed to support a population with our future age distribution. Read More

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http://www.healthaffairs.org/doi/10.1377/hlthaff.2019.00095
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http://dx.doi.org/10.1377/hlthaff.2019.00095DOI Listing
April 2019
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High-throughput single-cell sequencing of paired TCRα and TCRβ genes for the direct expression-cloning and functional analysis of murine T cell receptors.

Eur J Immunol 2019 Apr 24. Epub 2019 Apr 24.

German Cancer Research Center, B Cell Immunology, Heidelberg, Germany.

Precise clonal and functional assessments of the T cell receptor (TCR) repertoire diversity require paired TCRα and TCRβ gene sequence information at monoclonal level. However, available single-cell strategies are typically limited in throughput and often do not provide full-length DNA templates for direct gene cloning. Here, we describe a high-throughput strategy for the unbiased amplification and automated sequence analysis of paired TCRα and TCRβ genes from primary mouse T cells. Read More

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http://dx.doi.org/10.1002/eji.201848030DOI Listing

Heart rate responses to different temperatures in juvenile Poppiana dentata ( ).

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies - UWI, St. Augustine, Trinidad and Tobago, West Indies.

Temperature is one of the main factors that influences cardiovascular functioning in ectotherms. Hence this study sought to investigate heart rate responses of a freshwater crab species, Poppiana dentata, to different temperature exposures since the species generally reside in habitats of fluctuating physicochemistry. Heart rates were non-invasively determined in juvenile crabs for three temperature regimes, each over an 8-day session; A: temperature exposures of 26 °C (2 days) to 30 °C (3 days) to 26 °C (3 days), B: 26 °C (2 days) to 32 °C (3 days) to 26 °C (3 days) and C: a control at constant 26 °C. Read More

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http://dx.doi.org/10.1590/1519-6984.188457DOI Listing

Strategies for preventing ventilator-associated pneumonia: an integrative review.

Rev Bras Enferm 2019 Mar-Apr;72(2):521-530. Epub 2019 Apr 18.

Universidade Federal de São Paulo, Escola Paulista de Enfermagem. São Paulo-SP, Brasil.

Objective: to identify studies about strategies for prevention of ventilator-associated pneumonia deployed in health services and classify their level of evidence.

Method: integrative review of the literature, in 7 databases, which included the following descriptors: Prevention and Control AND Pneumonia Ventilator-Associated AND Intensive Care Units AND Bundle AND Patient Care.

Results: twenty-three scientific productions were included. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0473DOI Listing

Teaching-service integration: building the educational workshop in healthcare.

Rev Bras Enferm 2019 Mar-Apr;72(2):375-382. Epub 2019 Apr 18.

Universidade Federal de Santa Catarina. Florianópolis-SC, Brasil.

Objective: To identify the pedagogical strategies and the elements that determine the construction of the educational workshop in healthcare at the teaching-service integration process.

Method: Collective case study with qualitative approach. The cases consisted of two undergraduate courses in nursing. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0008DOI Listing

The impact of an isoreticular expansion strategy on the performance of iodine catalysts supported in multivariate zirconium and aluminum metal-organic frameworks.

Dalton Trans 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry and Biochemistry, Texas Tech University, Box 1061, Lubbock, Texas 79409-1061, USA.

Iodine functionalized variants of DUT-5 (Al) and UiO-67 (Zr) were prepared as expanded-pore analogues of MIL-53 (Al) and UiO-67 (Zr). They were prepared using a combination of multivariate and isorecticular expansion strategies. Multivariate MOFs with a 25% iodine-containing linker was chosen to achieve an ideal balance between a high density of catalytic sites and sufficient space for efficient diffusion. Read More

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http://dx.doi.org/10.1039/c9dt00368aDOI Listing

In situ construction of hollow carbon spheres with N, Co, and Fe co-doping as electrochemical sensors for simultaneous determination of dihydroxybenzene isomers.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

College of Chemistry, Chemical Engineering and Environment, Minnan Normal University, Zhangzhou, 363000, China.

Control of the active sites/centers plays an important role in the design of novel electrode materials with unusual properties and achievement of sensors with high performance. In this study, three-dimensional (3D) freestanding multi-doped hollow carbon spheres (N-Co-Fe-HCS) with a layer thickness of 30 nm, which contained multiple active sites of the heteroatom N and transition metals (Co and Fe), were synthesized via a simple template method (with SiO2 as the template) and cost-efficient in situ self-polymerization, self-adsorption/reduction and carbonization strategies. Moreover, a series of hollow carbon sphere composites of the same family (N-HCS, N-Co-HCS and N-Fe-HCS) were prepared by this sensible process using the same method and precursors but different doping elements. Read More

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http://dx.doi.org/10.1039/c9nr01146cDOI Listing

An integrative bioinspired venation network with ultra-contrasting wettability for large-scale strongly self-driven and efficient water collection.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Laser Materials Processing Research Centre, School of Materials Science and Engineering, Tsinghua University, Key Laboratory for Advanced Materials Processing Technology, Ministry of Education, Beijing 100084, PR China.

Collection of water from the atmosphere is a potential route to alleviate the global water shortage. However, it is still difficult to find a strategy to collect sufficient water on a large surface and transport it all off the surface without additional energy input. Inspired by redbud leaves, herein, we proposed a new water-collecting configuration. Read More

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http://dx.doi.org/10.1039/c8nr10003aDOI Listing

Theranostics for Advanced Prostate Cancer: Current Indications and Future Developments.

Eur Urol Oncol 2019 Mar 31;2(2):152-162. Epub 2019 Jan 31.

Metropolitan Nuclear Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Context: Advanced prostate cancer (PCa) is a prominent cause of cancer death in men; positron emission tomography (PET) imaging may play a relevant role in detecting metastases and thus allowing a more tailored therapy in these patients. Radioligand therapy (RLT) may also gain relevance as a treatment strategy in advanced disease.

Objective: The aim of this review is to highlight how the recently developed theranostic processes may become a part of both the available diagnostic and the therapy arsenal in advanced PCa patients. Read More

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http://dx.doi.org/10.1016/j.euo.2019.01.001DOI Listing

Patient safety culture in Hungarian hospitals.

Int J Health Care Qual Assur 2019 Mar;32(2):412-424

Department of Nursing, Universitat Autònoma de Barcelona , Barcelona, Spain.

Purpose: The Hospital Survey on Patient Safety Culture (HSOPSC) is a rigorously designed tool for measuring inpatient safety culture. The purpose of this paper is to develop a cross-cultural HSOPSC for Hungary and determine its strengths and weaknesses.

Design/methodology/approach: The original US version was translated and adapted using existing guidelines. Read More

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http://dx.doi.org/10.1108/IJHCQA-02-2018-0048DOI Listing

Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality.

Antioxid Redox Signal 2019 Apr 24. Epub 2019 Apr 24.

University of Arizona, Health Sciences, Tucson, Arizona, United States ;

Significance: Acute respiratory distress syndrome (ARDS) is a severe, heterogeneous critical illness with staggering mortality that is influenced by environmental factors, such as mechanical ventilation, and genetic factors. Significant unmet needs in ARDS is addressing the paucity of validated predictive biomarkers for ARDS risk and susceptibility that hamper the conduct of successful clinical trials in ARDS and the complete absence of novel disease-modifying therapeutic strategies. Recent Advances: The current ARDS definition relies on clinical characteristics that fail to capture the diversity of disease pathology, severity, and mortality risk. Read More

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http://dx.doi.org/10.1089/ars.2018.7701DOI Listing

Proximity-Induced Cooperative Polymerization in "Hinged" Helical Polypeptides.

J Am Chem Soc 2019 Apr 23. Epub 2019 Apr 23.

Cooperative interactions and transitions are amongst the most im-portant strategies utilized by biological systems to regulate a variety of physical and chemical processes. We report herein an auto-accelerated, rapid cooperative polymerization of N-carboxyanhydrides (NCAs) with initiators structurally as simple as linear aliphatic diamines for the synthesis of polypeptides. The polymerization initiated by diamines proceeds via the formation of "hinged" polypeptides - two blocks of helical chains connected head-to-head by the diamine molecules in the polymerization solution. Read More

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http://dx.doi.org/10.1021/jacs.9b02298DOI Listing

Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis.

ACS Infect Dis 2019 Apr 24. Epub 2019 Apr 24.

This article reports the rational medicinal chemistry of a natural product, agrimophol (1), as a new disruptor of intrabacterial pH (pHIB) homeostasis in Mycobacterium tuberculosis (Mtb). Through the systematic investigation of the structure-activity relationship of 1, scaffold-hopping of the diphenylmethane scaffold, pharmacophore displacement strategies, and studies of the structure-metabolism relationship, a new derivative 5a was achieved. Compound 5a showed 100-fold increased potency in the ability to reduce pHIB to pH 4. Read More

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http://dx.doi.org/10.1021/acsinfecdis.8b00325DOI Listing

[Glucose metabolism modeling of diabetes patients with different intensities of aerobic exercise: an in silico study].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):274-280

Complex Systems Research Center, Shanxi University, Taiyuan 030006, P.R.China;Shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on Disease Control and Prevention, Shanxi University, Taiyuan 030006,

Exercise is vital for diabetics to improve their blood glucose level. However, the quantitative relationship between exercise modes (including types, intensity, time, etc.) and the blood glucose is still not clear. Read More

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http://dx.doi.org/10.7507/1001-5515.201805066DOI Listing

[Discussion on strategies of health literacy promotion for echinococcosis control in China].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Apr;31(1):94-97

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; WHO Collaborating Center for Tropical Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China.

This article analyzes recent progresses on health education and health promotion targeting echinococcosis control in the major endemic foci of China, and describes the problems, including lack of human echinococcosis control knowledge, low human health literacy levels, incomplete establishment of health promotion mode, and urgent efforts to achieve the goal of Health for All. In addition, the feasible measures and strategies on health literacy promotion for echinococcosis control are discussed in combination with the national health literacy promotion strategy according to Healthy China 2030. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019023DOI Listing

[Endemic status and control of animal schistosomiasis in China].

Authors:
Lin Jiao-Jiao

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Apr;31(1):40-46

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Key Laboratory of Animal Parasitology, Minis-try of Agriculture; National Reference Laboratory of Animal Schistosomiasis, Shanghai 200241, China.

This paper describes the damages caused by animal schistosomiasis and the role of animals in the transmission of schistosomiasis in China and reviews the progress of animal schistosomiasis control and the endemic status of animal schistosomiasis at various stages. Although the endemic situation of animal schistosomiasis has been effectively controlled, there are still multiple factors that affect the transmission of schistosomiasis, and there are still risks leading to reemergence or rebounding of schistosomiasis in local areas. Strengthening of schistosomiasis surveillance as well as the prevention and control effects in key areas, consolidation of schistosomiasis control achievements, resolving of key technical problems in the elimination of animal schistosomiasis and development of precise technical measures and strategies are needed to accelerate the progress towards the elimination of schistosomiasis in China. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018313DOI Listing
April 2019
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[Progress and challenges of global malaria elimination].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Mar;31(1):19-22

WHO Collaborating Center for Research and Training on Malaria Elimination, Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.

Recently, the global malaria control has achieved remarkable results, and the epidemic map of malaria has gradually shrinked. However, in the past two years, the number of malaria deaths remained at a high level, and the incidence of malaria has even risen, leading to the stagnant of malaria elimination. The main reasons include lacking of the well monitoring and response system, sensitivity declining of antimalarial drugs, the spread of insecticide resistance, and the reduction of financial support. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019006DOI Listing

Optical Coherence Tomography for the Diagnosis and Monitoring of Glaucoma.

Authors:
Ahnul Ha Ki Ho Park

Asia Pac J Ophthalmol (Phila) 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Since its introduction to the field of ophthalmology, optical coherence tomography (OCT) has been markedly improved in terms of imaging protocols, algorithms, and new parameters that have enhanced its utility for the diagnosis and assessment of glaucoma progression. In this review, we examine the clinical utility of OCT in the diagnosis of glaucoma and monitoring of its progression, and emphasize the technological advances that facilitate both glaucoma research and the formulation of clinical management strategies. Read More

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http://dx.doi.org/10.22608/APO.201902DOI Listing

Emulsion Techniques for the Production of Pharmacological Nanoparticles.

Macromol Biosci 2019 Apr 24:e1900063. Epub 2019 Apr 24.

Department of Materials Science and Engineering, School of Molecular Science and EngineeringVidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, 21210, Thailand.

Nanoparticles have the advantages over micron-sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Read More

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http://dx.doi.org/10.1002/mabi.201900063DOI Listing

Review article: A primer for clinical researchers in the emergency department: Part VIII. Implementation science: An introduction.

Emerg Med Australas 2019 Apr 24. Epub 2019 Apr 24.

Nursing Research Institute, St Vincent's Health Australia and Australian Catholic University, Sydney, New South Wales, Australia.

New research findings may not lead to change in practice, or a change at the front line may be delayed by years. A number of terms have been used to describe efforts and strategies to speed a change in evidence-based practice, such as: implementation science, knowledge translation, research translation and others. In contrast to traditional clinical research, implementation science generally aims to understand and change health professional behaviour to promote evidence uptake as opposed to attempting to change patient behaviour. Read More

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http://dx.doi.org/10.1111/1742-6723.13296DOI Listing

Exploiting Unique Biological Features of Leukemia Stem Cells for Therapeutic Benefit.

Stem Cells Transl Med 2019 Apr 23. Epub 2019 Apr 23.

Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target genes and to fully understand their associated molecular network in these stem cells. Human chronic myeloid leukemia (CML) is well accepted as one of the typical types of hematopoietic malignancies that are derived from leukemia stem cells (LSCs), serving as an excellent model disease for understanding the biology of LSCs and developing effective, selective, and curative strategies through targeting LSCs. Read More

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http://dx.doi.org/10.1002/sctm.18-0247DOI Listing

Viral infection in primary antibody deficiency syndromes.

Rev Med Virol 2019 Apr 24:e2049. Epub 2019 Apr 24.

Institute of Immunity and Transplantation, Royal Free Campus, University College, London, UK.

Patients with primary antibody deficiency syndromes such as X-linked agammaglobulinemia (XLA) and common variable immunodeficiency (CVID) are at increased risk of severe and invasive infection. Viral infection in these populations has been of increasing interest as evidence mounts that viruses contribute significant morbidity and mortality: this is mediated both directly and via aberrant immune responses. We explain the importance of the humoral immune system in defence against viral pathogens before highlighting several significant viral syndromes in patients with antibody deficiency. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rmv.2049
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http://dx.doi.org/10.1002/rmv.2049DOI Listing
April 2019
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'Transformed rights' sexual health programme evaluation for the parents and service workers of adults with an intellectual disability.

J Intellect Disabil Res 2019 Apr 23. Epub 2019 Apr 23.

Teacher Education and Career Development Center, University of Taipei, Taipei, Taiwan.

Background: To promote sexual health in adults with an intellectual disability (ID) in Taiwan, sexual health programmes were provided to adults with ID, their parents and service workers. This study evaluates the impact of these programmes that involved the parents and service workers.

Methods: Intervention and participatory research paradigms were applied to develop, implement and evaluate programmes that address the challenges that relate to the sexual rights of adults with ID. Read More

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http://dx.doi.org/10.1111/jir.12624DOI Listing

Moderate activation of Wnt/β-catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence.

J Cell Biochem 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

This study aimed to investigate the specific role of Wnt/β-catenin signaling in compression-induced apoptosis, autophagy, and senescence in rat nucleus pulposus (NP) cells. Initially, the cells underwent various periods of exposure to 1.0 MPa compression. Read More

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http://dx.doi.org/10.1002/jcb.28518DOI Listing

Establishment of Sandwich Cultures of Primary Human Hepatocytes.

Methods Mol Biol 2019 ;1981:325-333

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium.

Primary hepatocytes and their adherent cultures are still considered as the golden standard in the field of liver-based in vitro modeling. However, they cope with progressive deterioration of their in vivo-like morphological and functional phenotype. Among the various strategies that are used to counteract this dedifferentiation process is the seeding and cultivation of freshly isolated or cryopreserved hepatocytes between two layers of extracellular matrix scaffolds. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_21DOI Listing
January 2019
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