549,619 results match your criteria Strategies for Studying Brain Disorders[Journal]


The Use of Mobile Educational Tools to Improve Antimicrobial Prescription for the Treatment of Acute Pyelonephritis in Pregnancy: A Retrospective Cross-sectional Study.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):97-101. Epub 2019 Feb 20.

Graduate Program in Medicine and Health Sciences, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

Objective:  To analyze the prescription of antimicrobial agents for pregnant women admitted into the obstetrics service who presented with acute pyelonephritis.

Methods:  Three cross-sectional studies were performed comparing the prescription of antimicrobials for pyelonephritis in pregnant women in the time periods evaluated (2010-2011: 99 patients evaluated; 2013: 116 patients evaluated; 2015: 107 patients evaluated), at the Hospital Fêmina, Porto Alegre, in the state of Rio Grande do Sul, Brazil. The analysis was performed before and after the promotion of an institutional protocol for the treatment of pyelonephritis during pregnancy, and on a third occasion after the introduction of a smartphone-based mobile educational tool. Read More

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http://dx.doi.org/10.1055/s-0039-1678590DOI Listing
February 2019
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Mechanisms of Sensory Discrimination: Insights from Drosophila Olfaction.

Annu Rev Biophys 2019 Feb 20. Epub 2019 Feb 20.

Centre for Neural Circuits and Behavior, University of Oxford , Oxford OX1 3SR, United Kingdom; email:

All an animal can do to infer the state of its environment is to observe the sensory-evoked activity of its own neurons. These inferences about the presence, quality, or similarity of objects are probabilistic and inform behavioral decisions that are often made in close to real time. Neural systems employ several strategies to facilitate sensory discrimination: Biophysical mechanisms separate the neuronal response distributions in coding space, compress their variances, and combine information from sequential observations. Read More

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http://dx.doi.org/10.1146/annurev-biophys-052118-115655DOI Listing
February 2019

Acoustic Pattern Recognition and Courtship Songs: Insights from Insects.

Annu Rev Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Princeton Neuroscience Institute , Princeton University, Princeton, New Jersey 08544, USA; email:

Across the animal kingdom, social interactions rely on sound production and perception. From simple cricket chirps to more elaborate bird songs, animals go to great lengths to communicate information critical for reproduction and survival via acoustic signals. Insects produce a wide array of songs to attract a mate, and the intended receivers must differentiate these calls from competing sounds, analyze the quality of the sender from spectrotemporal signal properties, and then determine how to react. Read More

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http://dx.doi.org/10.1146/annurev-neuro-080317-061839DOI Listing
February 2019

Laser Desorption Combined with Laser Postionization for Mass Spectrometry.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA; email:

Lasers with pulse lengths from nanoseconds to femtoseconds and wavelengths from the mid-infrared to extreme ultraviolet (UV) have been used for desorption or ablation in mass spectrometry. Such laser sampling can often benefit from the addition of a second laser for postionization of neutrals. The advantages offered by laser postionization include the ability to forego matrix application, high lateral resolution, decoupling of ionization from desorption, improved analysis of electrically insulating samples, and potential for high sensitivity and depth profiling while minimizing differential detection. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115447DOI Listing
February 2019

Local Administration of Magnesium Promotes Meniscal Healing Through Homing of Endogenous Stem Cells: A Proof-of-Concept Study.

Am J Sports Med 2019 Feb 20:363546518820076. Epub 2019 Feb 20.

Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background:: Although many strategies have been developed to modify the biological and biomechanical environment of the meniscal suture repair to improve the chances of healing, the failure rates remain high. Thus, new methods to promote meniscal regeneration and repair are needed.

Hypothesis:: Administration of magnesium (via a repair using magnesium stitches) might enhance recruitment and adherence of endogenous stem cells to the site of the lesion, thereby promoting in situ meniscal regeneration and chondroprotective functions. Read More

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http://dx.doi.org/10.1177/0363546518820076DOI Listing
February 2019

Enhancing the Treatment of Patients With Schizophrenia Through Continuous Care.

J Clin Psychiatry 2019 Feb 19;80(1). Epub 2019 Feb 19.

University of North Carolina School of Medicine, Carrboro, North Carolina, USA.

Schizophrenia is a chronic disorder that can be effectively controlled but will likely require lifelong treatment. Unfortunately, most patients experience numerous relapses, ongoing symptoms, and impairment, often because of treatment interruptions. Continuous treatment is imperative to prevent relapse and the potentially devastating consequences that can follow a return of psychotic symptoms. Read More

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http://dx.doi.org/10.4088/JCP.al18010ah2cDOI Listing
February 2019

Recent Advances of MOF-Derived Nanoporous Carbon Materials.

Chem Asian J 2019 Feb 20. Epub 2019 Feb 20.

Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia, AUSTRALIA.

Metal-organic frameworks (MOFs)-derived nanoporous carbon materials have received significant interest due to their advantages of controllable porosity, good thermal/chemical stability, high electrical conductivity, catalytic activity, easy modification with other elements and materials, etc. Thus, MOF-derived carbons have been used in numerous applications such as environment, energy storage systems (i.e. Read More

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http://doi.wiley.com/10.1002/asia.201900026
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http://dx.doi.org/10.1002/asia.201900026DOI Listing
February 2019
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Current state-of-the-art and future perspectives of the three main modern implant-dentistry concerns: aesthetic requirements, mechanical properties and peri-implantitis prevention.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

Nanomaterials and Nanotechnology Research Centre (CINN), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Oviedo (UO), Principado de Asturias (PA), Avenida de la Vega 4-6, 33940 El Entrego, Asturias, Spain.

The idea of permanent tooth replacement goes back to the year 2000 BC at least, when carved bamboo pegs were used to replace missing teeth in ancient China. The phenomenon of osseointegration, however, was not verified until the mid-1960's, when Pr. Branemark discovered that titanium could integrate to bone. Read More

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http://dx.doi.org/10.1002/jbm.a.36661DOI Listing
February 2019

Progress toward Understanding the Interactions between DNA Nanostructures and the Cell.

Small 2019 Feb 20:e1805416. Epub 2019 Feb 20.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Advances in DNA nanotechnology empower the programmable assembly of DNA building blocks (oligonucleotides and plasmids) into DNA nanostructures with precise architectural control. As DNA nanostructures are biocompatible and can naturally enter mammalian cells without the aid of transfection agents, they have found numerous biological or biomedical applications as delivery carriers of therapeutic and imaging cargoes into mammalian cells for at least a decade. Nevertheless, mechanistic studies on how DNA nanostructures interact with cells have remained limited and incomprehensive until 2-3 years ago. Read More

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http://dx.doi.org/10.1002/smll.201805416DOI Listing
February 2019

Hematopoietic stem cell transplantation in children with sickle cell anemia: The parents' experience.

Pediatr Transplant 2019 Feb 20:e13376. Epub 2019 Feb 20.

Department of Psychopathology, Avicenne Hospital, Paris XIII University & Assistance Publique-Hôpitaux de Paris, Bobigny, France.

Genoidentical HSCT is currently the only curative treatment for SCA, preventing further vascular complications in high-risk children. Studies on the psychological implications of HSCT for recipient, sibling donor, and the rest of the family have been limited in SCA. This study enrolled ten families and used semi-structured interviews to explore the parents' experience at three time points: first before transplantation, then 3 months later, and 1 year later. Read More

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http://dx.doi.org/10.1111/petr.13376DOI Listing
February 2019

Creating Cell and Animal Models of Human Disease by Genome Editing Using CRISPR/Cas9.

J Gene Med 2019 Feb 20:e3082. Epub 2019 Feb 20.

Department of Genetics, Shiraz University of Medical Science, Shiraz, Iran.

Aims: Set of unique sequences in bacterial genomes, responsible for protecting bacteria against bacteriophages, have been recently used for genetic manipulation of specific points in the genome. These system comprises of one RNA component and one enzyme component, known as CRISPR and Cas9, respectively. The present review focuses on the applications of the CRISPR/Cas9 technology in the development of cellular and animal models of human disease. Read More

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http://dx.doi.org/10.1002/jgm.3082DOI Listing
February 2019

Adherence assessment practices in haemodialysis settings: a qualitative exploration of nurses and pharmacists' perspectives.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

School of Healthcare, University of Leeds, Leeds, United Kingdom.

Aims And Objectives: To explore clinician assessment of patient adherence, and identify strategies to improve adherence assessment practices in haemodialysis settings.

Background: Patients with chronic kidney disease undergoing haemodialysis are typically prescribed complex regimens; as such, they are at high risk of medication nonadherence. Current clinical practices focus on prescribing medications, however, little attention is paid to measuring and ensuring patient adherence to their prescribed treatments. Read More

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http://dx.doi.org/10.1111/jocn.14821DOI Listing
February 2019

Bayesian personalized treatment selection strategies that integrate predictive with prognostic determinants.

Biom J 2019 Feb 20. Epub 2019 Feb 20.

Quantitative Health Sciences and The Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

The evolution of "informatics" technologies has the potential to generate massive databases, but the extent to which personalized medicine may be effectuated depends on the extent to which these rich databases may be utilized to advance understanding of the disease molecular profiles and ultimately integrated for treatment selection, necessitating robust methodology for dimension reduction. Yet, statistical methods proposed to address challenges arising with the high-dimensionality of omics-type data predominately rely on linear models and emphasize associations deriving from prognostic biomarkers. Existing methods are often limited for discovering predictive biomarkers that interact with treatment and fail to elucidate the predictive power of their resultant selection rules. Read More

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http://dx.doi.org/10.1002/bimj.201700323DOI Listing
February 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant non-small cell lung cancer.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China.

Oncogenic KRAS is considered a promising target for anti-cancer therapy. However, direct pharmacological strategies targeting KRAS-driven cancers remained unavailable. The prenyl-binding protein PDEδ, a transporter of KRAS, has been identified as a potential target for pharmacological inhibitor by selectively binding to its prenyl-binding pocket, impairing oncogenic KRAS signaling pathway. Read More

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http://dx.doi.org/10.1002/ijc.32222DOI Listing
February 2019

Is it true that gut microbiota is considered as panacea in cancer therapy?

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran.

Recent studies demonstrated that a combination of the gut microbiome has the vital effect on the efficacy of anticancer immune therapies. Regulatory effects of microbiota have been shown in different types of cancer therapies such as chemotherapy and immunotherapy. Immune-checkpoint-blocked therapies are the recent efficient cancer immunotherapy strategies. Read More

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http://dx.doi.org/10.1002/jcp.28333DOI Listing
February 2019

Improving risk stratification strategies for thyroid disease during pregnancy.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Depts. of Internal Medicine, Erasmus University Medical Center, the Netherlands.

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http://dx.doi.org/10.1210/jc.2019-00336DOI Listing
February 2019

The risk factors for diabetic peripheral neuropathy: A meta-analysis.

PLoS One 2019 20;14(2):e0212574. Epub 2019 Feb 20.

Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212574PLOS
February 2019

Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease.

PLoS One 2019 20;14(2):e0211935. Epub 2019 Feb 20.

Division of Computer-Aided Drug Design, The Red-Green Research Centre, Dhaka, Bangladesh.

Among neurodegenerative disorders, Alzheimer's disease (AD) is one of the most common disorders showing slow progressive cognitive decline. Targeting acetylcholinesterase (AChE) is one of the major strategies for AD therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are compromised. Herein, we report the design of some copper and other metal based donepezil derivatives, employing density functional theory (DFT). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211935PLOS
February 2019

Analysis of development and evolution rules of civil aviation in China based on life cycle theory.

PLoS One 2019 20;14(2):e0212338. Epub 2019 Feb 20.

National Key Laboratory of ATC Safety Technology, Civil Aviation University of China, Tianjin, China.

The development of CAAC began in the early days of 1949. From a comparatively less popular means of transport to the world's second largest by volume, this means of transport has undergone major and minor changes in the last 70 years. It is not known whether there are significant laws in the process of development. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212338PLOS
February 2019

Significance of subepithelial deposits in patients diagnosed with IgA nephropathy.

PLoS One 2019 20;14(2):e0211812. Epub 2019 Feb 20.

Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.

Subepithelial deposits are observed in rare adult IgA nephropathy (IgAN) cases and are a key diagnostic finding in IgA-dominant infection-related glomerulonephritis (IgA-IRGN). Sometimes, it is difficult to distinguish IgA-IRGN from IgAN without a precise clinical history. We hypothesized that some IgA-IRGN cases might be diagnosed as IgAN with subepithelial deposits (IgAN-SD) and aimed to clarify the significance of subepithelial deposits in patients diagnosed with IgAN. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211812PLOS
February 2019

Mental health in individuals with spinal cord injury: The role of socioeconomic conditions and social relationships.

PLoS One 2019 20;14(2):e0206069. Epub 2019 Feb 20.

Swiss Paraplegic Research, Nottwil, Switzerland.

Objectives: To evaluate socioeconomic inequalities in social relationships, and to assess whether socioeconomic conditions and social relationships are independently related to mental health problems in individuals with a physical disability due to spinal cord injury (SCI).

Methods: We analyzed cross-sectional data from 511 individuals with SCI aged over 16 years who participated in the community survey of the Swiss SCI Cohort Study (SwiSCI). Indicators for socioeconomic conditions included years of formal education, household income, and financial strain. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206069PLOS
February 2019

Volitional control of single-electrode high gamma local field potentials (LFPs) by people with paralysis.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Neuroscience, Brown University, United States.

Intracortical brain-computer interfaces (BCIs) can enable individuals to control effectors, such as a computer cursor, by directly decoding the user's movement intentions from action potentials and local field potentials (LFPs) recorded within the motor cortex. However, the accuracy and complexity of effector control achieved with such "biomimetic" BCIs will depend on the degree to which the intended movements used to elicit control modulate the neural activity. In particular, channels that do not record distinguishable action potentials and only record LFP modulations may be of limited use for BCI control. Read More

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http://dx.doi.org/10.1152/jn.00131.2018DOI Listing
February 2019

TDP-43: A KEY THERAPEUTIC TARGET BEYOND AMYOTROPHIC LATERAL SCLEROSIS.

ACS Chem Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Accumulation of TDP-43 in the cytoplasm of diseased neurons is the pathological hallmark of Frontotemporal Dementia-TDP (FTLD-TDP) and Amyotrophic Lateral Sclerosis (ALS), two diseases that lack of efficacious medicine to prevent or to stop disease progression. The discovery that mutations in the TARDBP gene (coding for the nuclear protein known as TDP-43) in both FTLD and ALS patients provided evidence for a link between TDP-43 alterations and neurodegeneration. The knowledge of TDP-43 function has advanced profoundly in the last years, however its complete role and the molecular mechanisms that lead to disease have yet to be fully understood. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00026DOI Listing
February 2019

Boron Dipyrromethene Nano-Photosensitizers for Anticancer Phototherapies.

Small 2019 Feb 20:e1804927. Epub 2019 Feb 20.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024, China.

As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and excellent photostability. After being formed into nanostructures, BODIPY-containing nano-photosensitizers show enhanced water solubility and biocompatibility as well as efficient tumor accumulation compared to BODIPY molecules. Hence, BODIPY nano-photosensitizers demonstrate a promising potential for fighting cancer. Read More

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http://doi.wiley.com/10.1002/smll.201804927
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http://dx.doi.org/10.1002/smll.201804927DOI Listing
February 2019
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Materials and Designs for Wearable Photodetectors.

Adv Mater 2019 Feb 20:e1808138. Epub 2019 Feb 20.

Department of Materials Science, Fudan University, Shanghai, 200433, P. R. China.

Photodetectors (PDs), as an indispensable component in electronics, are highly desired to be flexible to meet the trend of next-generation wearable electronics. Unfortunately, no in-depth reviews on the design strategies, material exploration, and potential applications of wearable photodetectors are found in literature to date. Thus, this progress report first summarizes the fundamental design principles of turning "hard" photodetectors "soft," including 2D (polymer and paper substrate-based devices) and 1D PDs (fiber shaped devices). Read More

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http://dx.doi.org/10.1002/adma.201808138DOI Listing
February 2019

Risk factors for hypertension in Canada.

Health Rep 2019 Feb;30(2):3-13

Health Analysis Division, Statistics Canada, Ottawa Hospital Research Institute, and the Institute of Clinical and Evaluative Sciences, Ottawa, Ontario.

Background: Hypertension (or high blood pressure) affects almost one in four adults in Canada. Quantifying risk factors associated with hypertension may help to inform prevention efforts.

Data And Methods: Data from the first four cycles of the Canadian Health Measures Survey (including 13,407 respondents) were used to identify hypertension status by systolic and diastolic blood pressure levels and the use of antihypertensive medications. Read More

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February 2019

Effects of long-term diet supplementation with Gliricidia sepium foliage mixed with Enterolobium cyclocarpum pods on enteric methane, apparent digestibility, and rumen microbial population in crossbred heifers.

J Anim Sci 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Veterinary Medicine and Animal Science, University of Yucatan, Carretera Merida-Xmatkuil, Itzimna, Merida, Yucatan, Mexico, C.P.

In the last decades, strategies have been evaluated to reduce rumen methane (CH4) production by supplementing tropical forages rich in secondary compounds; however, most of these beneficial effects need to be validated in terms of their persistence over time. The aim of this study was to assess CH4 emissions over time in heifers fed with and without Gliricidia sepium foliage (G) mixed with ground pods of Enterolobium cyclocarpum(E). Two groups of four crossbred (Bos taurus x Bos indicus) heifers (284 ±17 kg initial weight) were fed with two diets (0 and 15% of a mixture of the pods and foliage [E+G:0 and E+G:15, respectively] over 80 days, plus two weeks before the experiment, in which every animal was fed a legume and pod-free diet. Read More

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http://dx.doi.org/10.1093/jas/skz067DOI Listing
February 2019

Comparative Effectiveness of Adjunctive Psychotropic Medications in Patients With Schizophrenia.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York.

Importance: People with schizophrenia are commonly treated with psychotropic medications in addition to antipsychotics, but there is little evidence about the comparative effectiveness of these adjunctive treatment strategies.

Objective: To study the comparative real-world effectiveness of adjunctive psychotropic treatments for patients with schizophrenia.

Design, Setting, And Participants: This comparative effectiveness study used US national Medicaid data from January 1, 2001, to December 31, 2010, to examine the outcomes of initiating treatment with an antidepressant, a benzodiazepine, a mood stabilizer, or another antipsychotic among adult outpatients (aged 18-64 years) diagnosed with schizophrenia who were stably treated with a single antipsychotic. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4489DOI Listing
February 2019

Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications.

Braz J Med Biol Res 2019 Feb 14;52(2):e8209. Epub 2019 Feb 14.

Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha, Vila Velha, ES, Brasil.

Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264. Read More

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http://dx.doi.org/10.1590/1414-431X20188209DOI Listing
February 2019

Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles.

An Acad Bras Cienc 2019 Feb 14;91(suppl 1):e20180751. Epub 2019 Feb 14.

Biocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro, 21941-909 Rio de Janeiro, RJ, Brazil.

The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substituted regioisomer. The unique properties of these N2-substituted 1,2,3-triazoles have stimulated synthetic efforts on the developments of methodologies capable of delivering it in high yield and selectivity. Read More

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http://dx.doi.org/10.1590/0001-3765201820180751DOI Listing
February 2019

Deimplementation of Routine Chest X-rays in Adult Intensive Care Units.

J Hosp Med 2019 Feb;14(2):83-89

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: Choosing Wisely® is a national initiative to deimplement or reduce low-value care. However, there is limited evidence on the effectiveness of strategies to influence ordering patterns.

Objective: We aimed to describe the effectiveness of an intervention to reduce daily chest X-ray (CXR) ordering in two intensive care units (ICUs) and evaluate deimplementation strategies. Read More

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http://dx.doi.org/10.12788/jhm.3129DOI Listing
February 2019

Modeling epidemics in seed systems and landscapes to guide management strategies: The case of sweetpotato in Northern Uganda.

Phytopathology 2019 Feb 20. Epub 2019 Feb 20.

University of Florida, 3463 , Plant Pathology Department , Institute for Sustainable Food Systems , Emerging Pathogens Institute , Gainesville, Florida, United States , 32611-7011 ;

Seed systems are critical for deployment of improved varieties, but also can serve as major conduits for the spread of seed-borne pathogens. As in many other epidemic systems, epidemic risk in seed systems often depends on the structure of networks of trade, social interactions, and landscape connectivity. In a case study, we evaluated the structure of an informal sweetpotato seed system in the Gulu Region of Northern Uganda, for its vulnerability to the spread of emerging epidemics, and its utility for disseminating improved varieties. Read More

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http://dx.doi.org/10.1094/PHYTO-03-18-0072-RDOI Listing
February 2019

Reviewing the Potential Vectors and Hosts of African Swine Fever Virus Transmission in the United States.

Vector Borne Zoonotic Dis 2019 Feb 20. Epub 2019 Feb 20.

1 Texas A&M AgriLife Research, Department of Entomology, Texas A&M University, College Station, Texas.

African swine fever virus (ASFV) continues to threaten global animal health and agricultural biosecurity. Mitigating the establishment of ASFV in the United States (U.S. Read More

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http://dx.doi.org/10.1089/vbz.2018.2387DOI Listing
February 2019

Update and future perspective of behavioral medicine in the treatment for chronic pain.

Pain Manag 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, University of California Irvine, CA 92868, USA 92868.

Chronic pain is a biopsychosocial condition, and behavioral medicine has made significant contributions to the understanding of the phenomenon and optimization of therapeutic outcomes. The objective of this article is to provide future perspectives of behavioral medicine in pain management based upon recent development in the field. We will briefly review the mainstream approach of cognitive-behavioral therapy, its variations and new and innovative approaches that are on the horizon. Read More

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http://dx.doi.org/10.2217/pmt-2017-0055DOI Listing
February 2019

Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes.

Arch Pathol Lab Med 2019 Jan;143(1):34-46

From the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada (Dr Hodgson); and the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Park).

Context.—: Cervical adenocarcinomas are a heterogeneous group of tumors with varying morphologies, etiologies, molecular drivers, and prognoses, comprising approximately 25% of all cervical cancers. Unlike cervical squamous cell carcinoma, adenocarcinomas are not uniformly caused by high-risk human papillomavirus (HPV) infection and, therefore, would not necessarily be prevented by the HPV vaccine. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-025
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http://dx.doi.org/10.5858/arpa.2018-0259-RADOI Listing
January 2019
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Thermodynamically Consistent Force Field for Coarse-Grained Modeling of Aqueous Electrolyte Solution.

J Phys Chem B 2019 Feb 20. Epub 2019 Feb 20.

We propose a thermodynamically consistent methodology to parameterize interactions between charged particles inside the dissipative particle dynamics (DPD) formalism. We used osmotic pressure experimental data as a function of the salinity in order to optimize interaction parameters. Results for NaCl aqueous solution show that both mean osmotic and activity coefficient of individual ions allow to determine the Na+-water, Cl--water and Na+-Cl- DPD repulsion parameters. Read More

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http://dx.doi.org/10.1021/acs.jpcb.8b11190DOI Listing
February 2019

Adduct Fluorescence as a Tool to Decipher Sequence Impact on Frameshift Mutations Mediated by a C-Linked C8-Biphenyl-Guanine Lesion.

Chem Res Toxicol 2019 Feb 20. Epub 2019 Feb 20.

Aromatic chemicals can undergo metabolic activation to afford electrophilic species that react at the C8-site of 2'-deoxyguanosine (dG) to generate bulky C8-dG adducts as a basis of initiating carcinogenesis. These DNA lesions have served as models to understand the mechanism of frameshift mutagenesis, especially within CG-dinucleotide repeat sequences, such as NarI (5'-GGCXCC-3', where X = C8-dG adduct). However, there is still limited capacity to predict the likelihood of mutation arising within particular contexts and hence chemistry-based strategies are needed for probing relationships between nucleic acid sequence and structure with replication errors. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.9b00016DOI Listing
February 2019

Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques.

Inorg Chem 2019 Feb 20. Epub 2019 Feb 20.

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences , Monash University , Parkville , Victoria , Australia , 3052.

Amyloid-β plaques, consisting of aggregated amyloid-β peptides, are one of the pathological hallmarks of Alzheimer's disease. Copper complexes formed using positron-emitting copper radionuclides that cross the blood-brain barrier and bind to specific molecular targets offer the possibility of noninvasive diagnostic imaging using positron emission tomography. New thiosemicarbazone-pyridylhydrazone based ligands that incorporate pyridyl-benzofuran functional groups designed to bind amyloid-β plaques have been synthesized. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03466DOI Listing
February 2019

Dendritic Janus Nanomotors with Precisely Modulated Coverages and their Effects on Propulsion.

ACS Appl Mater Interfaces 2019 Feb 20. Epub 2019 Feb 20.

Asymmetric dual-function of Janus micro/nanoparticles that have different surface modifications, structures or material properties, are extremely promising as building blocks in constructing micro-/nanomotors. However, current synthesis strategies are usually lack of controlling the coverages of Janus micro/nanoparticles, which hinders in-depth researches of their effects on the performance of Janus nanomotors. This study demonstrates a versatile approach for fabrication of Janus dendritic porous silica nanomotors with precisely modulated coverages from 0 to 100% by controlling the embedded depth of aminopropyl-modified dendritic porous silica nanoparticles (DPSNs-NH2) with positive charges and subsequently adsorbing the oppositely charged Pt nanoparticles. Read More

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http://dx.doi.org/10.1021/acsami.8b22612DOI Listing
February 2019

New technical approach for type B dissection: from the PETTICOAT to the STABILISE concept.

J Cardiovasc Surg (Torino) 2019 Feb 20. Epub 2019 Feb 20.

Department of Vascular Surgery, San Raffaele Scientific Institute, Vita-Salute University School of Medicine, Milan, Italy.

Endovascular treatment of acute complicated type B aortic dissection (TBD) has recently acquired a primary therapeutic role when anatomically feasible. However, strategies meant to simply close the proximal entry tear leave the risk of persistent perfusion of the false lumen(FL) through additional tears in the thoracoabdominal aorta, and therefore the potential for aneurysmal degeneration remains significant over the years. Thus, additional bare stent implantation in the thoracoabdominal aorta has been proposed to promote true lumen (TL)expansion, malperfusion relief, and intimal lamella stabilization. Read More

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http://dx.doi.org/10.23736/S0021-9509.19.10904-4DOI Listing
February 2019

Italian expert panel consensus statements on two-drug antiretroviral regimens to treat naïve and virologically suppressed HIV-1 infected patients.

New Microbiol 2019 Feb 20;42(1). Epub 2019 Feb 20.

Infectious Diseases, University of "Rome "Tor Vergata". Rome, Italy.

New strategies for HIV treatment able to reduce drug-exposure, medium-long term toxicities and costs are a recognized clinical need. The availability of newer drugs with improved potency and tolerability, as well as high genetic barrier to resistance, makes antiretroviral-sparing strategies with two-drug regimens (2DRs) particularly attractive. Substantial evidence has been generated over the last few years supporting 2DR in virologically suppressed HIV infected patients for whom a therapy switch is planned. Read More

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February 2019

Dilemmas and New Paradigms in Asthma Management.

J Investig Allergol Clin Immunol 2019 Feb;29(1):15-23

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

Asthma is one of the most common inflammatory diseases in the world. The main goal of treatment is to achieve optimal control. Although every patient is different, clinical practice guidelines can help physicians to manage the disease. Read More

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http://dx.doi.org/10.18176/jiaci.0345DOI Listing
February 2019

Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer's disease.

Redox Biol 2019 Feb 1;22:101133. Epub 2019 Feb 1.

Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Our understanding of the mechanisms underlying process in Alzheimer's disease (AD) is far from completion and new therapeutic targets are urgently needed. Recently, the link between dementia and diabetes mellitus (DM) prompted us to search for new therapeutic strategies from glucose metabolism regulators for neurodegeneration. Previous studies have indicated that fibroblast growth factor 21 (FGF21), an attractive and potential therapeutic treatment for DM, may exert diverse effects in the central nervous system. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101133DOI Listing
February 2019

Is the incorporation of the newborn examination in the pre-registration curriculum acceptable in clinical practice? A qualitative study.

Nurse Educ Pract 2019 Feb 13;35:117-123. Epub 2019 Feb 13.

University of Plymouth, Devon, PL4 8AA, United Kingdom. Electronic address:

The objectives of this qualitative study were to describe the experiences of currently practicing newborn examiner midwives who had accessed their training post registration; explore their views on the inclusion of newborn examination in the pre-registration curriculum and invite them to identify strategies to achieve practical implementation of the inclusion of the newborn examination in pre-registration in the practice setting. Data were collected through semi-structured interviews and analysed using Thematic Analysis with an inductive approach. Three main themes were identified; experiences of the role, views of the newborn examination being incorporated into the pre-registration midwifery curriculum and practical considerations. Read More

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http://dx.doi.org/10.1016/j.nepr.2019.02.003DOI Listing
February 2019

T-bet B cells: A common denominator in protective and autoreactive antibody responses?

Curr Opin Immunol 2019 Feb 19;57:40-45. Epub 2019 Feb 19.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

T-bet B cells have emerged as a key component of the humoral immune response in both infections and autoimmune disorders, with many of their phenotypic and functional attributes conserved between mice and humans. They are protective (infections) and pathogenic (autoimmunity), although the associated commonalities and differences remain unclear. Heterogeneity within this pool, in terms of origin, fate and function may underlie these divergent roles. Read More

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http://dx.doi.org/10.1016/j.coi.2019.01.002DOI Listing
February 2019

Evaluating reinforcement learning agents for anatomical landmark detection.

Med Image Anal 2019 Feb 14;53:156-164. Epub 2019 Feb 14.

Biomedical Image Analysis Group (BioMedIA), Imperial College London, London, UK.

Automatic detection of anatomical landmarks is an important step for a wide range of applications in medical image analysis. Manual annotation of landmarks is a tedious task and prone to observer errors. In this paper, we evaluate novel deep reinforcement learning (RL) strategies to train agents that can precisely and robustly localize target landmarks in medical scans. Read More

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http://dx.doi.org/10.1016/j.media.2019.02.007DOI Listing
February 2019

The association between frequency of opioid misuse and opioid use disorder among youth and adults in the United States.

Drug Alcohol Depend 2019 Feb 13;197:73-77. Epub 2019 Feb 13.

Science Policy Branch, Office of Science Policy and Communications, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Blvd, Fifth Floor, Rockville, MD 20852, United States; Milken Institute School of Public Health, George Washington University, 950 New Hampshire Ave, NW, Washington DC 20052, United States.

Background: Studies have shown the frequency of drug misuse is important in the development of a substance use disorder, but little is known about this relationship in the context of opioid misuse and opioid use disorder and withdrawal symptoms.

Methods: Our study included 2694 civilian respondents from the United States 12 years and older who had misused prescription opioids in the past year from the 2014 National Survey on Drug Use and Health. Logistic regression was used to model the association between frequency of prescription opioid misuse and opioid use disorder and withdrawal symptoms, adjusting for age, sex, race/ethnicity, and income level. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.008DOI Listing
February 2019

Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action.

Biomed Pharmacother 2019 Feb 19;112:108643. Epub 2019 Feb 19.

Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.

Biologically active compounds from species of the phylum Basidiomycota have been shown a wide range of pharmacological activities and provide a vast reservoir of potential innovational drugs. The aim of this review is to discuss some mechanisms of action involved in antioxidant, anti-inflammatory and cytotoxic/antitumoral activities attributed to the bioactive compounds from species of the phylum Basidiomycota. We show that isolated compounds from extracts, secondary metabolites and polysaccharides that presented antioxidant properties have mechanisms of action involved in the elimination/capture of free radicals and reduction of lipid peroxidation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108643DOI Listing
February 2019

Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing.

Biomed Pharmacother 2019 Feb 19;112:108615. Epub 2019 Feb 19.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, 492010, Raipur, C.G., India. Electronic address:

Wound management in diabetic patient is of an extreme clinical and social concern. The delayed and impaired healing makes it more critical for research focus. The research on impaired healing process is proceeding hastily evident by new therapeutic approaches other than conventional such as single growth factor, dual growth factor, skin substitutes, cytokine stimulators, cytokine inhibitors, matrix metalloproteinase inhibitors, gene and stem cell therapy, extracellular matrix and angiogenesis stimulators. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108615DOI Listing
February 2019
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