4,575 results match your criteria Strahlentherapie und Onkologie[Journal]


[Management of immunological adverse events in patients treated with immune checkpoint inhibitors: ASCO clinical practice guideline summary].

Authors:
Mechthild Krause

Strahlenther Onkol 2019 Feb 15. Epub 2019 Feb 15.

Klinik für Strahlentherapie, Universitätsklinikum Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01436-7DOI Listing
February 2019

[Local radiotherapy for patients with newly diagnosed, metastatic prostate cancer].

Strahlenther Onkol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiation Oncology, Competence Center Palliative Care, University Hospital Zurich (USZ), Rämistrasse 100, 8091, Zurich, Schweiz.

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http://dx.doi.org/10.1007/s00066-019-01435-8DOI Listing
February 2019

[Patients with metastatic spinal cord compression profit from rapid multidisciplinary diagnostics and treatment].

Authors:
Carsten Nieder

Strahlenther Onkol 2019 Feb 14. Epub 2019 Feb 14.

Nordland Hospital Trust, 8092, Bodø, Norwegen.

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http://dx.doi.org/10.1007/s00066-019-01437-6DOI Listing
February 2019

Reply to the letter to the editor "Comment to 'Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials'".

Strahlenther Onkol 2019 Feb 13. Epub 2019 Feb 13.

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

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http://dx.doi.org/10.1007/s00066-019-01433-wDOI Listing
February 2019
2.914 Impact Factor

Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study.

Strahlenther Onkol 2019 Feb 11. Epub 2019 Feb 11.

Radiation Immuno-Oncology, Center for Translational Cancer Research TUM (TranslaTUM), Einsteinstr. 25, 81675, Munich, Germany.

Background: Membrane heat shock protein 70 (mHsp70) is indicative of high-risk tumors and serves as a tumor-specific target for natural killer (NK) cells stimulated with Hsp70 peptide (TKD) and Interleukin(IL)-2. Radiochemotherapy (RCT), mHsp70-targeting NK cells, and programmed death(PD)-1 inhibition were combined to improve the efficacy of tumor-specific immune cells in a non-small cell lung carcinoma (NSCLC) patient.

Patient: Following simultaneous RCT (64. Read More

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http://link.springer.com/10.1007/s00066-019-01434-9
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http://dx.doi.org/10.1007/s00066-019-01434-9DOI Listing
February 2019
2 Reads

The value of pretreatment serum butyrylcholinesterase level as a novel prognostic biomarker in patients with cervical cancer treated with primary (chemo-)radiation therapy.

Strahlenther Onkol 2019 Feb 8. Epub 2019 Feb 8.

Department for Gynecology and Gynecologic Oncology, Gynecologic Cancer Unit, Comprehensive Cancer Centre, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Deficiency in butyrylcholinesterase (BChE), a condition commonly noticed in liver damage, inflammation, and malnutrition, has previously been associated with impaired prognosis in different malignancies. The aim of the present study was to investigate the value of pretreatment serum BChE levels as a prognostic biomarker in patients with cervical cancer treated with primary (chemotherapy-[chemo-])radiation therapy.

Methods: We retrospectively evaluated data of a consecutive series of patients with cervical cancer treated with primary (chemo-)radiation therapy between 1998 and 2015. Read More

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http://dx.doi.org/10.1007/s00066-019-01430-zDOI Listing
February 2019
1 Read

Combination of stereotactic radiotherapy and targeted therapy: patterns-of-care survey in German-speaking countries.

Strahlenther Onkol 2019 Feb 8. Epub 2019 Feb 8.

Department of Radiation Oncology, University Hospital Zurich, Rämistrasse 100, 8091, Zürich, Switzerland.

Introduction: Stereotactic body radiotherapy (SBRT) is increasingly used in metastasized patients receiving targeted/immunotherapy. Information on safety and effectivity of concurrent SBRT and targeted/immunotherapy remains limited, resulting in a lack of consensus on treatment strategies. This study aimed to investigate how SBRT-experienced centers in German-speaking countries combine both therapies. Read More

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http://dx.doi.org/10.1007/s00066-018-01422-5DOI Listing
February 2019

Outcome of loco-regional radiotherapy in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate.

Strahlenther Onkol 2019 Jan 30. Epub 2019 Jan 30.

Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: To evaluate the potential benefit of curative radiotherapy (RT) to the primary tumor in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone.

Materials And Methods: The clinical parameters of 106 mCRPC patients treated with abiraterone were retrospectively evaluated. Patients were either oligometastatic (≤5 metastases) at diagnosis or became oligometastatic after the systemic treatment was analyzed. Read More

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http://dx.doi.org/10.1007/s00066-019-01429-6DOI Listing
January 2019
1 Read

Risk of cardiotoxicity induced by adjuvant anthracycline-based chemotherapy and radiotherapy in young and old Asian women with breast cancer.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China.

Purpose: The risk of cardiotoxicity induced by adjuvant anthracycline-based chemotherapy (CT) and radiotherapy (RT) is yet to be investigated in a large-scale randomized controlled trial with an adequate sample size of young and old women with breast cancer.

Patients And Methods: To compare the occurrence of major heart events (heart failure and coronary artery disease) in patients with breast cancer, 3489 women who underwent surgical resection of the breast tumor were retrospectively selected from the Taiwan National Health Insurance Research Database. The patients were categorized into the following groups based on their treatment modalities: group 1 (n = 1113), no treatment; group 2 (n = 646), adjuvant RT alone; group 3 (n = 705), adjuvant anthracycline-based CT alone; and group 4 (n = 1025), combined adjuvant RT and anthracycline-based CT. Read More

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http://dx.doi.org/10.1007/s00066-019-01428-7DOI Listing
January 2019

[Reduced radiation-induced brain necrosis in nasopharyngeal cancer patients with bevacizumab monotherapy].

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Klinik für Strahlentherapie & Ambulanzzentrum Strahlentherapie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01425-wDOI Listing
January 2019

[Impact of surgical approach on prognosis in early-stage cervical cancer].

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

MVZ im Fürstenberg-Karree, Institut für Zytologie Dysplasie, Hohenzollerndamm 123, 14199, Berlin, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01426-9DOI Listing
January 2019

Heparin treatment mitigates radiation-induced oral mucositis in mice by interplaying with repopulation processes.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiation Oncology-ATRAB-Applied and Translational Radiobiology, Department of Radiation Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Purpose: To investigate the mechanistic background of the muco-protective effect of systemic heparin treatment on the development of radiation-induced oral mucositis in mice.

Materials And Methods: Fractionated irradiation was given to the snouts of male C3H/Neu mice over 2 weeks (10 × 3 Gy), either alone or in combination with daily subcutaneous application of unfractionated or low molecular weight heparin (40 or 200 I.U. Read More

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http://dx.doi.org/10.1007/s00066-018-01423-4DOI Listing
January 2019

Radiotherapy-induced dysphagia and its impact on quality of life in patients with nasopharyngeal carcinoma.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120, Guangzhou, Guangdong Province, China.

Purpose: To investigate the swallowing status and its impact on quality of life (QOL) in patients who underwent radiotherapy for nasopharyngeal carcinoma (NPC).

Methods: In this study, 334 patients with NPC who underwent radiotherapy were reviewed. Clinical characteristics, videofluoroscopic swallowing studies (VFSSs), and scores of the World Health Organization quality of life-BREF (WHOQOL-BREF) were retrospectively analyzed for all patients. Read More

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http://dx.doi.org/10.1007/s00066-018-01421-6DOI Listing
January 2019

Stereotactic body radiotherapy of central lung malignancies using a simultaneous integrated protection approach : A prospective observational study.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Radiation Oncology, IRCCS, Sacro Cuore-Don Calabria Hospital, Negrar-Verona, Italy.

Aim: It is recognized that stereotactic body radiotherapy (SBRT) for centrally located lung metastases is affected by higher rates of severe toxicity. In the present study, we report the clinical outcomes following a novel intensity-modulated radiotherapy prescription dose, termed simultaneous integrated protection (SIP), for nearby organs at risk (OARs).

Materials And Methods: The prescribed total doses of SBRT were 70 Gy in 10 fractions and 60 Gy in 8 fractions. Read More

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http://dx.doi.org/10.1007/s00066-018-01419-0DOI Listing
January 2019
1 Read

Clinical safety and efficacy of salvage reirradiation for upper abdominal malignancies.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic of).

Purpose: Reirradiation has the potential to provide effective local control of upper abdominal malignancies. This study aimed to evaluate the safety and efficacy of reirradiation for upper abdominal malignancies.

Methods: A total of 42 patients with a history of prior radiotherapy (RT) received reirradiation for abdominal malignancies between 2005 and 2017. Read More

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http://dx.doi.org/10.1007/s00066-018-01420-7DOI Listing
January 2019

[The end of TPF induction for locally advanced head and neck cancer? Induction chemotherapy followed by cetuximab and radiotherapy is not superior to concurrent chemoradiotherapy].

Strahlenther Onkol 2019 Jan 21. Epub 2019 Jan 21.

Klinik für Strahlentherapie und Spezielle Onkologie, Medizinische Hochschule Hannover, Hannover, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01427-8DOI Listing
January 2019
2 Reads

ICRU report 91 on prescribing, recording, and reporting of stereotactic treatments with small photon beams : Statement from the DEGRO/DGMP working group stereotactic radiotherapy and radiosurgery.

Strahlenther Onkol 2019 Jan 16. Epub 2019 Jan 16.

Klinik für Strahlentherapie, Universitätsspital Zürich, Zürich, Switzerland.

The International Commission on Radiation Units and Measurements (ICRU) report 91 with the title "prescribing, recording, and reporting of stereotactic treatments with small photon beams" was published in 2017. This extensive publication covers different relevant aspects of stereotactic radiotherapy such as small field dosimetry, accuracy requirements for volume definition and planning algorithms, and the precise application of treatment by means of image guidance. Finally, recommendations for prescribing, recording and reporting are given. Read More

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http://link.springer.com/10.1007/s00066-018-1416-x
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http://dx.doi.org/10.1007/s00066-018-1416-xDOI Listing
January 2019
3 Reads

Predicting tumor responses and patient survival in chemoradiotherapy-treated patients with non-small-cell lung cancer using dynamic contrast-enhanced integrated magnetic resonance-positron-emission tomography.

Strahlenther Onkol 2019 Jan 4. Epub 2019 Jan 4.

Department of Medical Imaging, National Taiwan University Hospital, National Taiwan University College of Medicine, No.7, Chung-Shan South Road, 100, Taipei, Taiwan.

Purpose: We investigated whether radiologic parameters by dynamic contrast-enhanced (DCE) integrated magnetic resonance-positron-emission tomography (MR-PET) predicts tumor response to treatment and survival in non-metastatic non-small-cell lung cancer (NSCLC) patients receiving chemoradiotherapy (CRT).

Methods: Patients underwent DCE integrated MR-PET imaging 1 week before CRT. The following parameters were analyzed: primary tumor size, gross tumor volume, maximal standardized uptake value (SUV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC), volume transfer constant (K), reverse reflux rate constant (k), extracellular extravascular volume fraction (v), blood plasma volume fraction (v), and initial area under the time-concentration curve defined over the first 60 s post-enhancement (iAUC). Read More

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http://dx.doi.org/10.1007/s00066-018-1418-8DOI Listing
January 2019
2.914 Impact Factor

Is there a patient population with squamous cell carcinoma of the head and neck region who might benefit from de-intensification of postoperative radiotherapy? : A monocentric retrospective analysis of a previously defined low-risk patient population treated with standard-of-care radiotherapy.

Strahlenther Onkol 2019 Jan 4. Epub 2019 Jan 4.

Department of Radiation Oncology, University Hospital of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 27, 91054, Erlangen, Germany.

Purpose: The aim of this retrospective study was to evaluate the clinical outcome of a previously defined low-risk patient population with completely resected (R0) squamous cell carcinoma of the oral cavity, oropharynx, larynx (pT1-3, pN0-pN2b), hypopharynx (pT1-2, pN0-pN1), and the indication for postoperative radio(chemo)therapy.

Patients And Methods: According to predefined criteria, 99 patients with head and neck squamous cell carcinoma (SCC) who were treated at our institution from January 1, 2005 to December 31, 2014, were available for analysis. The Kaplan-Meier method was used for calculating survival and incidence rates. Read More

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http://dx.doi.org/10.1007/s00066-018-1415-yDOI Listing
January 2019
1 Read

Comparison of  Ga-PSMA ligand PET/CT versus conventional cross-sectional imaging for target volume delineation for metastasis-directed radiotherapy for metachronous lymph node metastases from prostate cancer.

Strahlenther Onkol 2019 Jan 4. Epub 2019 Jan 4.

Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To assess the differences in the target volume (TV) delineation of metachronous lymph node metastases between  Ga-PSMA ligand PET/CT and conventional imaging in a comparative retrospective contouring study.

Patients And Methods: Twenty-five patients with biochemical prostate cancer recurrence after primary prostatectomy underwent  Ga-PSMA ligand PET/CT in addition to conventional imaging techniques such as CT and/or MR imaging for restaging. All patients were diagnosed with at least one lymph node metastasis. Read More

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http://dx.doi.org/10.1007/s00066-018-1417-9DOI Listing
January 2019
4 Reads

Comment to Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials.

Strahlenther Onkol 2019 Jan 4. Epub 2019 Jan 4.

Klinik für RadioOnkologie und Strahlentherapie, St. Marienkrankenhaus Siegen, 57072, Siegen, Germany.

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http://dx.doi.org/10.1007/s00066-018-1411-2DOI Listing
January 2019
1 Read

Hyperthermic chest wall re-irradiation in recurrent breast cancer: a prospective observational study.

Strahlenther Onkol 2019 Jan 3. Epub 2019 Jan 3.

Department of Radiation Oncology, University Hospital and Medical Faculty Tübingen, Eberhard Karls University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Purpose: To prospectively investigate the role of re-irradiation (re-RT) combined with hyperthermia (HT) in a contemporary cohort of patients affected by recurrent breast cancer (RBC).

Methods: Within the prospective registry HT03, patients with resected RBC and previous irradiation were included. Re-RT was applied to the recurrence region with doses of 50-50. Read More

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http://link.springer.com/10.1007/s00066-018-1414-z
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http://dx.doi.org/10.1007/s00066-018-1414-zDOI Listing
January 2019
2 Reads

A comparison of a brachytherapy and an external beam radiotherapy boost in breast-conserving therapy for breast cancer: local and any recurrences.

Strahlenther Onkol 2019 Jan 2. Epub 2019 Jan 2.

Department of Oncology, Experimental Radiation Oncology, KU Leuven-University of Leuven, 3000, Leuven, Belgium.

Purpose: Adding a tumour bed boost to whole-breast irradiation in breast-conserving therapy reduces local recurrence rates. The purpose of the present study was to investigate whether the boost technique influences the magnitude of the effect.

Methods: Patients treated with breast-conserving therapy for invasive breast cancer between 2000 and 2007 were included in the analysis. Read More

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http://dx.doi.org/10.1007/s00066-018-1413-0DOI Listing
January 2019
2 Reads

Low-dose radiotherapy: Mayday, mayday. We've been hit!

Strahlenther Onkol 2018 Dec 18. Epub 2018 Dec 18.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Universitätsstr. 27, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00066-018-1412-1DOI Listing
December 2018
1 Read

[Risk of second malignancies after platinum-based chemotherapy of testicular cancer].

Strahlenther Onkol 2019 Feb;195(2):190-191

Universitätsklinik für Radioonkologie, Eberhard Karls Universität, Tübingen, Deutschland.

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http://dx.doi.org/10.1007/s00066-018-1410-3DOI Listing
February 2019
1 Read

[Stereotactic body radiation therapy is superior to sorafenib in terms of survival in patients with hepatocellular carcinoma].

Strahlenther Onkol 2019 Feb;195(2):188-189

Klinik für Strahlentherapie, Universitätsklinikum Schleswig-Holstein, Kiel, Deutschland.

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http://dx.doi.org/10.1007/s00066-018-1408-xDOI Listing
February 2019
1 Read

CT-based dose recalculations in head and neck cancer radiotherapy: comparison of daily dose recalculations to less time-consuming approaches.

Strahlenther Onkol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Straße 22, 81675, Munich, Germany.

Background: The goal of this study was to investigate if daily dose recalculations are necessary or if less time-consuming approaches can be used to identify dose differences to the planned dose in patients with head and neck cancers (H&N).

Methods: For 12 H&N patients treated with helical tomotherapy, daily dose calculations were performed retrospectively. Four different summation doses (SuDo) were calculated: DayDo (daily dose calculation), MVCTx2, MVCTx5, and MVCTx10 (dose calculations every second, fifth, and tenth fraction). Read More

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http://dx.doi.org/10.1007/s00066-018-1406-zDOI Listing
December 2018
3 Reads

[Genetic risk factors for a second neoplasm in children who have survived a first malignant disease].

Authors:
Martin G Sauer

Strahlenther Onkol 2019 Feb;195(2):186-187

Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, OE 6780, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland.

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http://dx.doi.org/10.1007/s00066-018-1409-9DOI Listing
February 2019
1 Read

Institutional patient accrual volume and the treatment quality of I‑125 prostate seed implantation in a Japanese nationwide prospective cohort study.

Strahlenther Onkol 2018 Dec 5. Epub 2018 Dec 5.

Japanese Foundation for Prostate Research, Tokyo, Japan.

Purpose: It is unclear whether experience at high-volume institute improves the treatment quality of prostate seed implantation. The aim of this study was to evaluate the effect of institutional experience on postimplant dosimetric parameters in a nationwide prospective cohort study.

Methods: From July 2005 to June 2007, 2354 patients were registered in the Japanese Prostate Cancer Outcome Study of Permanent I‑125 Seed Implantation (J-POPS), and 1126 patients treated with seed implantation alone were evaluated. Read More

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http://link.springer.com/10.1007/s00066-018-1407-y
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http://dx.doi.org/10.1007/s00066-018-1407-yDOI Listing
December 2018
7 Reads

Palliative care in everyday practice of radiation oncologists : Results from a web-based survey among medical members of the German Society for Radiation Oncology (DEGRO).

Strahlenther Onkol 2018 Nov 29. Epub 2018 Nov 29.

Interdisciplinary centre for palliative medicine and Department of Radiation Oncology, Julius-Maximilians-University, Würzburg, Germany.

Purpose: Little is known about the attitudes of radiation oncologists towards palliative care, about their competences in this field, and about the collaboration with palliative care specialists. Our aim was to close this gap and understand more about the importance of an additional qualification in palliative care.

Methods: Medical members of the German Society for Radiation Oncology (DEGRO) were electronically surveyed during November-December 2016. Read More

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http://dx.doi.org/10.1007/s00066-018-1403-2DOI Listing
November 2018
1 Read

Impact of androgen deprivation therapy on apparent diffusion coefficient and T2w MRI for histogram and texture analysis with respect to focal radiotherapy of prostate cancer.

Strahlenther Onkol 2018 Nov 26. Epub 2018 Nov 26.

Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.

Purpose: Accurate prostate cancer (PCa) detection is essential for planning focal external beam radiotherapy (EBRT). While biparametric MRI (bpMRI) including T2-weighted (T2w) and diffusion-weighted images (DWI) is an accurate tool to localize PCa, its value is less clear in the case of additional androgen deprivation therapy (ADT). The aim of this study was to investigate the value of a textural feature (TF) approach on bpMRI analysis in prostate cancer patients with and without neoadjuvant ADT with respect to future dose-painting applications. Read More

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http://dx.doi.org/10.1007/s00066-018-1402-3DOI Listing
November 2018
2 Reads

Linac-based radiosurgery or fractionated stereotactic radiotherapy with flattening filter-free volumetric modulated arc therapy in elderly patients : A mono-institutional experience on 110 brain metastases.

Strahlenther Onkol 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiation Oncology, IRCCS, Sacro Cuore Don Calabria Hospital, Via don A. Sempreboni 5, 37024, Negrar, Verona, Italy.

Aim: The aim of this study was to analyze the feasibility and clinical results of linear accelerator (linac-)based stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (SFRT) with flattening filter-free (FFF) volumetric modulated arc therapy (VMAT) in elderly patients affected by brain metastases (BMs).

Patients And Methods: Patients selected for the present analysis were ≥65 years old with a life expectancy of >3 months, a controlled or synchronous primary tumor, and <10 BMs with a diameter <3 cm. All patients were treated with FFF linac-based SRS/SFRT. Read More

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http://link.springer.com/10.1007/s00066-018-1405-0
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http://dx.doi.org/10.1007/s00066-018-1405-0DOI Listing
November 2018
11 Reads

Biliary duct stenosis after image-guided high-dose-rate interstitial brachytherapy of central and hilar liver tumors : A systematic analysis of 102 cases.

Strahlenther Onkol 2018 Nov 23. Epub 2018 Nov 23.

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, Marchioninistraße 15, 81377, München, Germany.

Objective: Image-guided high-dose-rate interstitial brachytherapy (iBT) with iridium-192 is an effective treatment option for patients with liver malignancies. Little is known about long-term radiation effects on the bile duct system when central hepatic structures are exposed to iBT. This retrospective analysis investigates the occurrence of posthepatic cholestasis (PHC) and associated complications in patients undergoing iBT. Read More

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http://dx.doi.org/10.1007/s00066-018-1404-1DOI Listing
November 2018
12 Reads
2.914 Impact Factor

A fatal case of Fournier's gangrene during neoadjuvant radiotherapy for rectal cancer.

Strahlenther Onkol 2018 Nov 23. Epub 2018 Nov 23.

Department of Radiation Oncology, Leopoldina Hospital Schweinfurt, Robert-Koch-Straße 10, 97422, Schweinfurt, Germany.

Purpose: To report the development of an ultimately fatal occurrence of Fournier's gangrene in a rectal cancer patient undergoing neoadjuvant radiotherapy without chemotherapy.

Methods: A 53-year-old male patient with G2 cT3 cN1a cM0 stage IIIB adenocarcinoma of the lower rectum and several comorbidities including ulcerative colitis was treated with 56 Gy to the primary tumor in 28 fractions because he declined the recommended simultaneous chemotherapy. He was also enrolled in the ketogenic diet arm of our KETOCOMP study, so that prospective measurements of blood parameters, quality of life, and body composition were made. Read More

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http://dx.doi.org/10.1007/s00066-018-1401-4DOI Listing
November 2018
7 Reads

Incidence of second primary cancers after radiotherapy combined with platinum and/or cetuximab in head and neck cancer patients.

Strahlenther Onkol 2018 Nov 21. Epub 2018 Nov 21.

Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 4, 3010, Bern, Switzerland.

Purpose: The second primary cancer (SPC) incidence after treatment with platinum-based chemotherapy and cetuximab in combination with radiotherapy has not been previously reported. Our aim was to compare SPC risk following radiotherapy in combination with these agents for the treatment of head and neck squamous cell carcinoma (HNSCC).

Methods: The charts of 296 cases treated for loco-regionally advanced HNSCC between 2009 and 2015 were retrospectively reviewed for patient, tumor, and procedural characteristics. Read More

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http://dx.doi.org/10.1007/s00066-018-1400-5DOI Listing
November 2018
9 Reads

Impact of bladder volume on acute genitourinary toxicity in intensity modulated radiotherapy for localized and locally advanced prostate cancer.

Strahlenther Onkol 2018 Nov 15. Epub 2018 Nov 15.

Department for Radiation Oncology, Charité-University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.

Background And Purpose: To evaluate the effect of changes in bladder volume during high-dose intensity-modulated-radiotherapy (IMRT) of prostate cancer on acute genitourinary (GU) toxicity and prospectively evaluate a simple biofeedback technique for reproducible bladder filling with the aim of reducing acute GU toxicity.

Methods: One hundred ninety-three patients were trained via a biofeedback mechanism to maintain a partially filled bladder with a reproducible volume of 200-300 cc at planning CT and subsequently at each fraction of radiotherapy. We prospectively analyzed whether and to what extent the patients' ability to maintain a certain bladder filling influenced the degree of acute GU toxicity and whether cut-off values could be differentiated. Read More

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http://link.springer.com/10.1007/s00066-018-1398-8
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http://dx.doi.org/10.1007/s00066-018-1398-8DOI Listing
November 2018
9 Reads

Correction to: Prof. Dr. Luther W. Brady verstorben.

Strahlenther Onkol 2018 12;194(12):1189-1190

, Alte Landstr. 220, 22391, Hamburg, Deutschland.

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http://dx.doi.org/10.1007/s00066-018-1399-7DOI Listing
December 2018
1 Read

Radiotherapy of epicondylitis humeri : Analysis of 138 elbows treated with a linear accelerator.

Strahlenther Onkol 2018 Nov 13. Epub 2018 Nov 13.

Department of Radiotherapy, Universitätsklinikum Regensburg, 94042, Regensburg, Germany.

Background: Epicondylitis humeri is a common disease with a prevalence of 1.7%. One of the treatment options is radiotherapy. Read More

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http://dx.doi.org/10.1007/s00066-018-1397-9DOI Listing
November 2018
3 Reads

Combined stereotactic body radiotherapy and trans-arterial chemoembolization as initial treatment in BCLC stage B-C hepatocellular carcinoma.

Strahlenther Onkol 2018 Nov 9. Epub 2018 Nov 9.

Department of Radiation Oncology, Universitatsklinikum Schleswig-Holstein, Kiel, Germany.

Purpose: We retrospectively evaluated the efficacy and safety of stereotactic body radiotherapy (SBRT) combined with trans-arterial chemoembolization (TACE) as initial therapy in Barcelona Clinic Liver Cancer (BCLC) system stage B-C hepatocellular carcinoma (HCC).

Patients And Methods: Seventy-two patients received a single dose of TACE followed by SBRT 4 weeks later. All patients had tumor sizes ≥5 cm, at least 700 ml of disease-free liver, Child-Pugh (CP) score ≤ B7 and tumor nodules ≤5. Read More

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http://link.springer.com/10.1007/s00066-018-1391-2
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http://dx.doi.org/10.1007/s00066-018-1391-2DOI Listing
November 2018
39 Reads
2.914 Impact Factor

[Adjuvant chemotherapy with cisplatin and gemcitabine after radiochemotherapy with curative intent does not improve relapse-free survival in nasopharyngeal cancer patients with persistently detectable EBV DNA].

Strahlenther Onkol 2019 Jan;195(1):90-91

Universitätsklinik für Strahlentherapie, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Deutschland.

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http://dx.doi.org/10.1007/s00066-018-1393-0DOI Listing
January 2019
6 Reads

Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy : Quality assessment within a randomized phase III trial testing a cardioprotective treatment strategy (SAFE-2014).

Strahlenther Onkol 2019 Jan 7;195(1):43-51. Epub 2018 Nov 7.

Department of Radiation Oncology, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134, Florence, Italy.

Background And Purpose: In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.

Patients And Methods: Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. Read More

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http://link.springer.com/10.1007/s00066-018-1388-x
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http://dx.doi.org/10.1007/s00066-018-1388-xDOI Listing
January 2019
24 Reads
2.914 Impact Factor

Patient- versus physician-reported outcomes in prostate cancer patients receiving hypofractionated radiotherapy within a randomized controlled trial.

Strahlenther Onkol 2018 Nov 7. Epub 2018 Nov 7.

Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.

Purpose: The risk of developing acute radiotherapy(RT)-induced side effects may increase with hypofractionated RT. To detect treatment-related side effects, patient-reported outcomes (PROs) might be more reliable than physician-reported outcomes. Therefore, we tried to evaluate the rate of agreement between urinary and gastrointestinal (GI) side effects and the prevalence of side effects reported by patients and by physicians. Read More

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http://link.springer.com/10.1007/s00066-018-1395-y
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http://dx.doi.org/10.1007/s00066-018-1395-yDOI Listing
November 2018
15 Reads
2.914 Impact Factor

Toxicity and risk factors after combined high-dose-rate brachytherapy and external beam radiation therapy in men ≥75 years with localized prostate cancer.

Strahlenther Onkol 2018 Nov 2. Epub 2018 Nov 2.

Department of Radiotherapy and Radiooncology, Outpatient Center, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Purpose: Combined high-dose-rate brachytherapy (HDR-BT) and external beam radiation therapy (EBRT) is a favorable treatment option in non-metastatic prostate cancer. However, reports on toxicity and outcome have mainly focused on younger patients. We aimed to determine toxicity and biochemical control rates after combined HDR-BT and EBRT in men ≥75 years. Read More

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http://link.springer.com/10.1007/s00066-018-1380-5
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http://dx.doi.org/10.1007/s00066-018-1380-5DOI Listing
November 2018
13 Reads

Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus.

Strahlenther Onkol 2018 Nov 2. Epub 2018 Nov 2.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Universitätsstr. 27, 91054, Erlangen, Germany.

Purpose: To compare results after chemoradiotherapy with and without deep regional hyperthermia in patients with anal cancer.

Methods: Between 2000 and 2015, a total of 112 consecutive patients with UICC stage I-IV anal cancer received chemoradiotherapy with 5‑fluororuracil and mitomycin C (CRT). In case of insufficient tumor response 4-6 weeks after chemoradiotherapy, patients received an interstitial pulsed-dose-rate brachytherapy boost. Read More

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http://link.springer.com/10.1007/s00066-018-1396-x
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http://dx.doi.org/10.1007/s00066-018-1396-xDOI Listing
November 2018
10 Reads

Cavity volume changes after surgery of a brain metastasis-consequences for stereotactic radiation therapy.

Strahlenther Onkol 2018 Nov 1. Epub 2018 Nov 1.

Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (TUM), Ismaninger Straße 22, 81675, Munich, Germany.

Purpose: For a large or symptomatic brain metastasis, resection and adjuvant radiotherapy are recommended. Hypofractionated stereotactic radiotherapy (HFSRT) is increasingly applied in patients with a limited number of lesions. Exact target volume definition is critical given the small safety margins. Read More

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http://link.springer.com/10.1007/s00066-018-1387-y
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http://dx.doi.org/10.1007/s00066-018-1387-yDOI Listing
November 2018
10 Reads

Is low dose radiotherapy an effective treatment for Baker's cyst?

Strahlenther Onkol 2019 Jan 30;195(1):69-76. Epub 2018 Oct 30.

Department of Nephrology, University of Regensburg, Regensburg, Germany.

Purpose: Osteoarthritis of the knee is a common disease, often associated with a Baker's cyst. Besides osteoarthritis, also other joint pathologies of the knee can be causative for a Baker's cyst. Radiotherapy is known to be an effective treatment for osteoarthritis, with an anti-inflammatory effect. Read More

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http://dx.doi.org/10.1007/s00066-018-1389-9DOI Listing
January 2019
3 Reads

[Adjuvant radiotherapy in the multimodal treatment of resectable gastric cancer-criticism of the conclusions drawn from CRITICS?]

Strahlenther Onkol 2019 Jan;195(1):86-89

Klinik für Strahlentherapie und Spezielle Onkologie, Medizinische Hochschule Hannover, Hannover, Deutschland.

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http://link.springer.com/10.1007/s00066-018-1394-z
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http://dx.doi.org/10.1007/s00066-018-1394-zDOI Listing
January 2019
8 Reads

Fractionated stereotactic radiation therapy for adrenal metastases: contributing to local tumor control with low toxicity.

Strahlenther Onkol 2018 Oct 29. Epub 2018 Oct 29.

Department of Radiation Oncology, Friedrich-Schiller-University Jena, Bachstraße 18, 07743, Jena, Germany.

Purpose: To report on the Erlangen (UK-Er) experience with linear accelerator stereotactic body radiation therapy (LINAC SBRT) for adrenal metastasis from various primary tumors.

Materials And Methods: 33 patients were treated. Primary sites included lung (n = 19), melanoma (n = 8), colorectal (n = 2), hepatocellular (n = 1), esophageal (n = 2), and breast cancer (n = 1). Read More

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http://link.springer.com/10.1007/s00066-018-1390-3
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http://dx.doi.org/10.1007/s00066-018-1390-3DOI Listing
October 2018
4 Reads

Comparison of treatment plans for a high-field MRI-linac and a conventional linac for esophageal cancer.

Strahlenther Onkol 2018 Oct 25. Epub 2018 Oct 25.

German Cancer Consortium (DKTK), Partner Site Tübingen; and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Purpose: To compare radiotherapy treatments plans in esophageal cancer calculated for a high-field magnetic resonance imaging (MRI)-linac with plans for a conventional linac.

Materials And Methods: Ten patients with esophageal squamous cell carcinomas were re-planned retrospectively using the research version of Monaco (V 5.19. Read More

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http://link.springer.com/10.1007/s00066-018-1386-z
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http://dx.doi.org/10.1007/s00066-018-1386-zDOI Listing
October 2018
3 Reads