9,037 results match your criteria Strahlentherapie und Onkologie[Journal]


LONG-TERM HEALTH RISK AFTER BREAST-CANCER RADIOTHERAPY: OVERVIEW OF PASSOS METHODOLOGY AND SOFTWARE.

Radiat Prot Dosimetry 2018 Dec 6. Epub 2018 Dec 6.

Klinik für Strahlentherapie, Universität Leipzig, Stephanstr. 9a, Leipzig, Germany.

Breast-cancer radiotherapy reduces the recurrence rates and improves patient survival. However, it also increases the incidence of second cancers and of heart disease. These radiation-induced long-term health risks become increasingly important with improved cure rates and prolonged patient survival. Read More

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December 2018

Effect of early salvage radiotherapy at PSA < 0.5 ng/ml and impact of post-SRT PSA nadir in post-prostatectomy recurrent prostate cancer.

Prostate Cancer Prostatic Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiation Oncology and Radiotherapy, University Hospital Ulm, Ulm, Germany.

Background: For patients with recurrent prostate cancer after radical prostatectomy (RP), salvage radiotherapy (SRT) offers a second chance of cure. European guidelines (EAU) recommend SRT at a PSA < 0.5 ng/ml. Read More

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November 2018

Enhancing radiotherapy effect in breast cancer with nanoparticles: A review.

Rep Pract Oncol Radiother 2019 Jan-Feb;24(1):65-67. Epub 2018 Nov 15.

Radiotherapy Department, Catalan Oncology Institute (ICO)-IDIBELL. Hospitalet, Barcelona, Spain.

Amongst all efforts for improving oncological management outcomes, nanoparticles enhanced radiation for breast cancer patient's treatment is a novel approach that has grown interest for research in the last decade. Multiple preclinical data has been published, from all around the globe; however, clinical evidence is still insufficient for implementing the method in routine practice and in disease specific management. Gold nanoparticles (AuNP), which may be among the most studed materials, account for the majority of available data; however, some new materials have also been used in preclinical settings. Read More

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November 2018

Biliary duct stenosis after image-guided high-dose-rate interstitial brachytherapy of central and hilar liver tumors : A systematic analysis of 102 cases.

Strahlenther Onkol 2018 Nov 23. Epub 2018 Nov 23.

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, Marchioninistraße 15, 81377, München, Germany.

Objective: Image-guided high-dose-rate interstitial brachytherapy (iBT) with iridium-192 is an effective treatment option for patients with liver malignancies. Little is known about long-term radiation effects on the bile duct system when central hepatic structures are exposed to iBT. This retrospective analysis investigates the occurrence of posthepatic cholestasis (PHC) and associated complications in patients undergoing iBT. Read More

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November 2018
6 Reads
2.914 Impact Factor

[Radiotherapeutic studies of head and neck cancer-highlights of the 2018 ASCO Annual Meeting].

HNO 2018 Dec;66(12):901-906

Hermann-Holthusen-Institut für Strahlentherapie, Asklepios Klinik St. Georg, Hamburg, Deutschland.

Background: Radiotherapy is an important treatment option in patients with advanced head and neck cancer. At the 2018 Annual Meeting of the American Society of Clinical Oncology (ASCO), study results were presented that could further develop and modify existing therapy concepts in the future.

Materials And Methods: All ASCO abstracts and presentations concerning radiotherapy of head and neck cancer were screened and the most interesting abstracts were selected for further review. Read More

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December 2018
6 Reads

[Adjuvant chemotherapy with cisplatin and gemcitabine after radiochemotherapy with curative intent does not improve relapse-free survival in nasopharyngeal cancer patients with persistently detectable EBV DNA].

Strahlenther Onkol 2018 Nov 8. Epub 2018 Nov 8.

Universitätsklinik für Strahlentherapie, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Deutschland.

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November 2018
2 Reads

[Adjuvant radiotherapy in the multimodal treatment of resectable gastric cancer-criticism of the conclusions drawn from CRITICS?]

Strahlenther Onkol 2018 Oct 29. Epub 2018 Oct 29.

Klinik für Strahlentherapie und Spezielle Onkologie, Medizinische Hochschule Hannover, Hannover, Deutschland.

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October 2018
4 Reads

Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 1 with Recommendations for the Screening, Diagnosis and Therapy of Breast Cancer.

Geburtshilfe Frauenheilkd 2018 Oct 19;78(10):927-948. Epub 2018 Oct 19.

Universitätsfrauenklinik Würzburg, Universität Würzburg, Würzburg, Germany.

The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer. The process of updating the S3 guideline dating from 2012 was based on the adaptation of identified source guidelines which were combined with reviews of evidence compiled using PICO (Patients/Interventions/Control/Outcome) questions and the results of a systematic search of literature databases and the selection and evaluation of the identified literature. The interdisciplinary working groups took the identified materials as their starting point to develop recommendations and statements which were modified and graded in a structured consensus procedure. Read More

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October 2018
8 Reads

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) - Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer.

Geburtshilfe Frauenheilkd 2018 Oct 19;78(10):949-971. Epub 2018 Oct 19.

Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany.

The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lead coordinators of the guideline were the German Society of Gynecology and Obstetrics (DGGG) and the Gynecological Oncology Working Group (AGO) of the German Cancer Society (DKG). The use of evidence-based, risk-adapted therapy to treat low-risk women with endometrial cancer avoids unnecessarily radical surgery and non-useful adjuvant radiotherapy and/or chemotherapy. Read More

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October 2018
6 Reads

Quality of life and oncological outcome in endometrial cancer patients after vaginal brachytherapy: comparison of two dosing schemes.

Arch Gynecol Obstet 2018 Oct 24. Epub 2018 Oct 24.

Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93051, Regensburg, Germany.

Purpose: Vaginal brachytherapy reduces the risk of local recurrence and was shown to be equieffective in preventing vaginal vault recurrence, but less toxic compared to external-beam radiotherapy in a subset of high intermediate-risk endometrial cancer patients and is administered as single adjuvant treatment in those patients. Different radiotherapeutic approaches with various dosing schemes exist toward brachytherapy. The aim of this study was to compare the outcome and long-term quality of life after brachytherapy with two different high-dose-rate dosing schemes. Read More

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October 2018
4 Reads

[Update on HPV-associated head and neck cancer-highlights of the 2018 ASCO Annual Meeting].

HNO 2018 Dec;66(12):888-895

Medizinische Fakultät, Klinik für Hals‑, Nasen‑, Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinik zu Köln, 50937, Köln, Deutschland.

Rising incidence rates in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) and a significantly improved prognosis have brought this entity into scientific focus. At this year's American Society of Clinical Oncology (ASCO) Annual Meeting, 291 studies with the keyword "HPV" were presented, the majority of which were in head and neck cancer. Due to high rates of late toxicities after conventional therapy, de-intensified treatment concepts are being increasingly discussed, although data from prospective phase III studies were not presented. Read More

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December 2018
8 Reads
0.540 Impact Factor

Exposure of remote organs and associated cancer risks from tangential and multi-field breast cancer radiotherapy.

Strahlenther Onkol 2018 Oct 22. Epub 2018 Oct 22.

Klinik und Poliklinik für Strahlentherapie, MVZ der Universitätsmedizin Rostock am Standort Südstadt gGmbH, Universitätsmedizin Rostock, Südring 75, 18059, Rostock, Germany.

Purpose: With the ever-increasing cure rates in breast cancer, radiotherapy-induced cancers have become an important issue. This study aimed to estimate secondary cancer risks for different treatment techniques, taking into account organs throughout the body.

Material And Methods: Organ doses were evaluated for a tangential three-dimensional conformal (3D-CRT) and a multi-field intensity-modulated radiotherapy (IMRT) plan using a validated, Monte Carlo-based treatment planning system. Read More

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October 2018

Concepts and terms for dose/volume parameters in carbon-ion radiotherapy: Conclusions of the ULICE taskforce.

Cancer Radiother 2018 Dec 13;22(8):802-809. Epub 2018 Oct 13.

Service de cancérologie-radiothérapie, hôpital Albert-Michallon, CHU Grenoble Alpes, 38043 Grenoble cedex 09, France; IPNL, France Hadron national research infrastructure, 69000 Lyon, France; Université Grenoble Alpes, 38400 Saint-Martin-d'Hères, France.

Purpose: The Union of Light Ion Centers in Europe (ULICE) program addressed the need for uniting scientific results for carbon-ion radiation therapy obtained by several institutions worldwide in different fields of excellence, and translating them into a real benefit to the community. Particularly, the concepts for dose/volume parameters developed in photon radiotherapy cannot be extrapolated to high linear energy transfer particles.

Methods And Materials: The ULICE-WP2 taskforce included radiation oncologists involved in carbon-ion radiation therapy and International Commission on Radiation Units and Measurements, radiation biologists, expert physicists in the fields of carbon-ion radiation therapy, microdosimetry, biological modeling and image-guided radiotherapy. Read More

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December 2018
3 Reads

[Combining radiotherapy with immunotherapy for urological malignancies].

Urologe A 2018 Nov;57(11):1309-1315

Univ.-Klinik für Strahlentherapie und Radioonkologie, Univ.-Klinik Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.

Photon radiotherapy has repeatedly been described to elicit effects beyond mere inhibition of tumor cell clonogenicity: immunomodulatory phenomena including radiation-induced expression of tumor-associated antigens, increased recruitment and functioning of immunocompetent cells and secretion of immunomodulatory messengers have been described to explain the radiation responses of tumor lesions outside of irradiated volumes ("abscopal effect") in both preclinical models and clinical cases. With radiotherapy only, the abscopal effect is only rarely observed, but several trials have suggested combining modern immunotherapy with radiation to increase both frequency and intensity of the abscopal effect. Urological malignancies are commonly described as immunogenic malignancies. Read More

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November 2018
5 Reads

Performance evaluation and first clinical experience with the Varian RGSC module for breath detection of 15 lung cancer patients.

Z Med Phys 2018 Oct 8. Epub 2018 Oct 8.

Department of Radiotherapy and Radiation Oncology, University Hospital of Düsseldorf, Germany. Electronic address:

The University Hospital of Düsseldorf, Germany (UKD) recently installed the Respiratory Gating for Scanners module (RGSC) (Varian Medical Systems, Palo Alto, USA). The aim of this article is to report on the commissioning and clinical implementation of the RGSC system. The steps encompassed the validation of the manufacturer's specifications including functionality tests using a commercial and in-house developed breathing phantom, to establish calibration procedures, and clinical workflow analysis involving breath acquisition and patient data evaluation. Read More

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October 2018
3 Reads

Intraoperative Electron Radiation Therapy Combined with External Beam Radiation Therapy after Gross Total Resection in Extremity Soft Tissue Sarcoma: A European Pooled Analysis.

Ann Surg Oncol 2018 Dec 1;25(13):3833-3842. Epub 2018 Oct 1.

Department of Radiotherapy, Helios Hospital Berlin-Buch, Berlin, Germany.

Introduction: We report a pooled analysis evaluating the combination of gross complete limb-sparing surgery, intraoperative electron radiation therapy (IOERT), and external beam radiation therapy (EBRT) in patients with extremity soft tissue sarcoma (STS).

Methods: Individual data of 259 patients (median follow-up 63 months) with extremity STS from three European expert centers were pooled. Median age was 55 years and median tumor size was 8 cm. Read More

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December 2018
1 Read

[Carboplatin does not increase the effectiveness of adjuvant radiotherapy in advanced cutaneous squamous cell carcinoma of the head and neck region].

Strahlenther Onkol 2018 12;194(12):1180-1182

Klinik für Strahlentherapie und Spezielle Onkologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

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December 2018
2 Reads

Practice Patterns of Stereotactic Radiotherapy in Pediatrics: Results From an International Pediatric Research Consortium.

J Pediatr Hematol Oncol 2018 Oct;40(7):522-526

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD.

Purpose/objectives: There is little consensus regarding the application of stereotactic radiotherapy (SRT) in pediatrics. We evaluated patterns of pediatric SRT practice through an international research consortium.

Materials And Methods: Eight international institutions with pediatric expertise completed a 124-item survey evaluating patterns of SRT use for patients 21 years old and younger. Read More

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October 2018
5 Reads

[Association of circulating tumor cell status with benefit of radiotherapy and survival in early-stage breast cancer].

Strahlenther Onkol 2018 11;194(11):1069-1071

Klinik und Poliklinik für RadioOnkologie und Strahlentherapie, Technische Universität München (TUM) Klinikum rechts der Isar, Ismaninger Straße 22, 81675, München, Deutschland.

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November 2018

Five-year effectiveness of low-dose-rate brachytherapy: comparisons with nomogram predictions in patients with non-metastatic prostate cancer presenting significant control of intra- and periprostatic disease.

J Contemp Brachytherapy 2018 Aug 31;10(4):297-305. Epub 2018 Aug 31.

Praxis für Brachytherapie, Praxiszentrum Alstertal, Hamburg.

Purpose: To assess the effectiveness of low-dose-rate (LDR) brachytherapy in patients with localized prostate cancer and to compare the outcome with predictions from Kattan and Partin nomograms at 60 months after seed implantation.

Material And Methods: One thousand, one hundred and eighty-seven patients with localized prostate cancer at low-, intermediate-, or high-risk of progression received LDR brachytherapy using iodine-125 seeds with curative intent, applied as monotherapy or in combination with external beam radiation therapy (EBRT), and/or androgen deprivation therapy (ADT). At 60 months after seed implantation, data of 1,064 patients (1,058 alive + 6 who died of prostate cancer) were analyzed for biochemical progression-free survival (bPFS) based on prostate-specific antigen (PSA) levels using the Phoenix definition. Read More

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August 2018
3 Reads

[Active surveillance and postponed operation after neoadjuvant radiochemotherapy for oesophageal cancer-findings of the preSANO study].

Strahlenther Onkol 2018 Sep 14. Epub 2018 Sep 14.

Klinik und Praxis für Strahlentherapie, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Deutschland.

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September 2018

Percutaneous parametrial dose escalation in women with advanced cervical cancer: feasibility and efficacy in relation to long-term quality of life.

Radiol Oncol 2018 Sep 11;52(3):320-328. Epub 2018 Sep 11.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.

Background We analyzed long-term quality of life (QoL) and prognostic factors for QoL as well as clinical outcome in patients with advanced cervical cancer (ACC) treated with primary radiochemotherapy (RChT) consisting of external beam radiotherapy (EBRT) with or without sequential or simultaneous integrated boost (SIB) to the parametria, intracavitary brachytherapy and concomitant chemotherapy (ChT). Patients and methods Eighty-three women were treated with primary RChT between 2008 and 2014. Survival of all patients was calculated and prognostic factors for survival were assessed in univariate and multivariate analysis. Read More

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September 2018

MRI-guided localization of the dominant intraprostatic lesion and dose analysis of volumetric modulated arc therapy planning for prostate cancer.

Strahlenther Onkol 2018 Sep 12. Epub 2018 Sep 12.

Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Würzburg, Josef-Schneider-Straße 11, 97080, Würzburg, Germany.

Purpose: Primary radiation therapy is a curative treatment option for prostate cancer. The aim of this study was to evaluate the detection of the dominant intraprostatic lesion (DIL) with magnetic resonance imaging (MRI) for radiotherapy treatment planning, the comparison with transrectal ultrasound (TRUS)-guided biopsies and the examination of the dose distribution in relation to the DIL location.

Materials And Methods: In all, 54 patients with treatment planning MRI for primary radiotherapy of prostate cancer from 03/2015 to 03/2017 at the Universitätsklinikum Würzburg were identified. Read More

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September 2018
1 Read

Short Communication: Management of patients with extensive-stage small-cell lung cancer treated with radiotherapy: A survey of practice.

Cancer Treat Res Commun 2018 30;17:18-22. Epub 2018 Aug 30.

Manchester Cancer Research Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, UK. Electronic address:

Objectives: The results of the randomized phase 3 CREST trial evaluating the use of thoracic radiotherapy for extensive-stage small-cell lung cancer (ES-SCLC) were published in the Lancet in 2015. The primary endpoint (10% overall survival difference at 1-year) was not achieved, but there was significant improvement in 2-year overall survival (13% vs 3%; p = 0.004) and low toxicity rates, suggesting thoracic radiotherapy should be considered for ES-SCLC patients who respond to chemotherapy. Read More

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[Treatment of malignant pleural mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline].

Strahlenther Onkol 2018 10;194(10):953-957

Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Regensburg, 93042, Regensburg, Deutschland.

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October 2018
1 Read

[Improved overall survival with brachytherapy in stage III endometrial cancer].

Authors:
Peter Niehoff

Strahlenther Onkol 2018 10;194(10):958-959

Klinik für Strahlentherapie, Sanaklinikum Offenbach, 63069, Offenbach, Deutschland.

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October 2018

[High-risk endometrial cancer: In each case an adjuvant radiochemotherapy?]

Strahlenther Onkol 2018 10;194(10):960-961

Klinik und Poliklinik für Strahlentherapie Rostock, Südring 75, 18059, Rostock, Deutschland.

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October 2018

Stereotactic radiotherapy for choroidal melanomas by means of HybridArc™ : Physics and technique of linac-based photon beam therapy.

Strahlenther Onkol 2018 Oct 16;194(10):929-943. Epub 2018 Aug 16.

Klinik für Strahlentherapie und Radioonkologie, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau-Roßlau, Germany.

Purpose: Stereotactic radiotherapy (SRT) is suitable to treat ocular tumours. The optimal beam geometry for SRT, however, has not been defined. Here we evaluate a combination technique with dynamic conformal arcs (DCAs) and intensity-modulated static fields (IMRT), known as HybridArc™ (HA). Read More

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October 2018
2 Reads

["Only a planning …"].

Radiologe 2018 08;58(8):705-707

Manchester Cancer Research Centre, The University of Manchester, 555 Wilmslow Road, M20 4GJ, Manchester, Vereinigtes Königreich.

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Complementary medicine in radiation oncology : German health care professionals' current qualifications and therapeutic methods.

Strahlenther Onkol 2018 Oct 2;194(10):904-910. Epub 2018 Aug 2.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675, Munich, Germany.

Introduction: Recently, complementary and alternative medicine (CAM) has moved more into the focus, and cancer societies such as the German Cancer Society (Deutsche Krebsgesellschaft, DKG) have established working groups to develop a guideline for CAM. The present work aims to evaluate the acceptance of CAM in the whole radiation oncology community.

Methods: We conducted an online survey on CAM and sent the modified questionnaire that was successfully distributed to all members of the Research Group on Gynecological Oncology (Arbeitsgemeinschaft Gynakologische Onkologie, AGO) of the DKG in 2014 to the members of the German Society of Radiation Oncology (Deutsche Gesellschaft für Radioonkologie und Strahlentherapie, DEGRO). Read More

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October 2018
10 Reads

Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Current Trends and Controversies.

Technol Cancer Res Treat 2018 01;17:1533033818790217

1 Department of Radiation Oncology, University of Washington, Seattle, WA, USA.

Hepatocellular carcinoma is the fourth leading cause of cancer-related death worldwide. Depending on the extent of disease and competing comorbidities for mortality, multiple liver-directed therapy options exist for the treatment of hepatocellular carcinoma. Advancements in radiation oncology have led to the emergence of stereotactic body radiation therapy as a promising liver-directed therapy, which delivers high doses of radiation with a steep dose gradient to maximize local tumor control and minimize radiation-induced treatment toxicity. Read More

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January 2018

[Myocardial infarction in a young patient with seminoma during chemotherapy with cisplatinum, etoposide, and bleomycin].

Aktuelle Urol 2018 Jul 31. Epub 2018 Jul 31.

Urologie, Asklepios Klinik Altona, Hamburg.

Introduction:  More than 90 % of all patients with testicular germ cell tumours can be cured effectively. The mainstay of treatment is chemotherapy with cisplatin, etoposide and bleomycin (PEB). This regimen is usually well tolerated and does not lead to serious adverse events. Read More

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July 2018
3 Reads

Is there a benefit of lymphadenectomy for overall and recurrence-free survival in type I FIGO IB G1-2 endometrial carcinoma? A retrospective population-based cohort analysis.

J Cancer Res Clin Oncol 2018 Oct 23;144(10):2019-2027. Epub 2018 Jul 23.

Klinik und Poliklinik für RadioOnkologie und Strahlentherapie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Purpose: The recommended therapy for type I FIGO IB endometrial cancer (EC) is hysterectomy and adnexectomy, but the therapeutic benefits of additional pelvic and paraaortic lymph node dissection (LND) are still under discussion. In this study, we retrospectively evaluated overall survival (OAS) and recurrence-free survival (RFS) among patients with type I FIGO IB EC who did undergo systematic or elective lymphadenectomy or none at all.

Methods: We selected 299 individuals from the database of the German Tumor Centre Regensburg who were diagnosed between 1998 and 2015 with endometrial adenocarcinoma of the uterus type I FIGO IB. Read More

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October 2018
3 Reads

A Definitive IMRT-SIB with Concomitant Chemotherapy for Synchronous Locally Advanced Anal Canal Cancer and Prostate Cancer.

Case Rep Oncol Med 2018 24;2018:6101759. Epub 2018 Jun 24.

Institut für Strahlentherapie/Radioonkologie, Feschnigstraße 11, 9020 Klagenfurt am Wörthersee, Austria.

Currently, there are no specific recommendations regarding the management of the synchronous tumours due to the lack of either specific guidelines or individuals' clinical experiences relative to these clinical situations. In the presence of a locally advanced double primary tumour and with the lymph node metastases in addition, from the radiotherapeutical point of view, it must be challenging to manage this complicated situation that requires a more delicate treatment planning, due to higher doses prescribed to greater volumes concomitantly with the chemotherapy. A 68-year-old Caucasian male with a synchronous intermediate-risk prostate adenocarcinoma and locally advanced anal canal carcinoma underwent IMRT-SIB with concomitant chemotherapy at our institute. Read More

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[Image-guided, minimally invasive surgery and other local therapeutic procedures for primary liver tumors].

Chirurg 2018 Nov;89(11):872-879

Institut für Diagnostische und Interventionelle Radiologie, Uniklinik Köln, Köln, Deutschland.

Background: The incidence of primary liver tumors is rising. Modern minimally invasive, image-guided procedures offer a potentially curative therapy option.

Objective: The aim of this study was to evaluate the multitude of image-guided minimally invasive procedures concerning their evidence-based effect on local tumor control and overall survival. Read More

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November 2018
4 Reads

NHL-ChirEx: An interprofessional cross-border education initiative in the Greater Region with a focus on radiation morbidity and patient safety.

Radiother Oncol 2018 Dec 10;129(3):417-420. Epub 2018 Jul 10.

Université de Lorraine, Nancy, France.

NHL-ChirEx is an interprofessional cross-border education project that addresses the potential excess of radiation induced morbidity throughout the radiation planning and treatment process. NHL-ChirEx is supported by ESTRO and the University of the Greater Region and has been recently approved and funded under INTERREG VA Programme. Read More

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December 2018

[Normal tissue: radiosensitivity, toxicity, consequences for planning].

Authors:
A Rühle P E Huber

Radiologe 2018 Jul 10. Epub 2018 Jul 10.

Abteilung für RadioOnkologie und Strahlentherapie, Universitätsklinik Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.

Along with chemotherapy, surgery and immunotherapy, radiotherapy is a mainstay of cancer treatment. Considering the improving survival rates for various malignancies during the past decades, the importance of radiation-induced late normal tissue response is increasing. Quality of life is becoming an important issue in modern cancer treatment and is correlated with acute and late normal tissue response after radiotherapy. Read More

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Ga-68-PSMA PET/CT in treatment-naïve patients with prostate cancer: Which clinical parameters and risk stratification systems best predict PSMA-positive metastases?

Prostate 2018 Jul 5. Epub 2018 Jul 5.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Radiologie, Berlin, Germany.

Purpose: To evaluate the accuracy of clinical parameters and established pre-treatment risk stratification systems for prostate cancer (PCa) in predicting PSMA-positive metastases in men undergoing Ga-68-PSMA PET/CT as initial staging examination.

Materials And Methods: A retrospective analysis in 108 consecutive treatment-naïve patients with biopsy-proven PCa undergoing Ga-68-PSMA PET/CT (median age, 72 years [range, 49-82 years]) was performed. Prediction of PSMA-positive metastases by serum PSA, clinical T stage (cT), ISUP group, percentage of positive biopsy cores, and derived risk scores (D'Amico risk classification system, Roach [RF], Yale formula [YF], and Briganti nomogram [BN]) was examined with ROC analysis. Read More

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July 2018
7 Reads

Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck - clinical results from the cohort of the clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer".

Radiat Oncol 2018 Jul 3;13(1):123. Epub 2018 Jul 3.

Clinical Cooperation Group 'Personalized Radiotherapy in Head and Neck Cancer', Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Background: Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer" focuses on the identification and validation of new biomarkers, which are aimed at eventually stratifying and personalizing the therapy concept. Hence, we reviewed all patients with head and neck squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx, treated with postoperative (chemo) radiation from 06/2008 until 06/2015 at the Department of Radiation Oncology in the University Hospital, LMU Munich. Read More

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July 2018
3 Reads

[Use of alternative medicine for cancer and impact on survival].

Strahlenther Onkol 2018 09;194(9):870-871

Klinik und Poliklinik für RadioOnkologie und Strahlentherapie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland.

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September 2018
1 Read

Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM (S2k-Level, AWMF Registry No. 015/082, November 2017) - Recommendations and Statements for Girls and Women.

Geburtshilfe Frauenheilkd 2018 Jun 25;78(6):567-584. Epub 2018 Jun 25.

Frauenklinik, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

Aim: The aim of this official guideline published by the German Society of Gynecology and Obstetrics (DGGG) and coordinated with the German Society of Urology (DGU) and the German Society of Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained by evaluating the relevant literature, on counseling and fertility preservation for prepubertal girls and boys as well as patients of reproductive age. Statements and recommendations for girls and women are presented below. Statements or recommendations for boys and men are not the focus of this guideline. Read More

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June 2018
11 Reads

[Imaging of side effects after radiation therapy].

Authors:
T Welzel J M Tanner

Radiologe 2018 Aug;58(8):754-761

Radiologische Klinik, Abt. für Radioonkologie u. Strahlentherapie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.

Background: Peritumoral normal tissue is inevitably also irradiated during radiotherapy, depending on the location and size of the target volume as well as the cumulative dose. Depending on the temporal course after irradiation acute, subacute, and chronic alterations are described in co-irradiated normal tissue that can be detected by imaging. Radiation damage can be transient or persistent. Read More

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August 2018
2 Reads

[Gross tumor volume (GTV) : Basics, methods, registration, limitations].

Authors:
C Thieke

Radiologe 2018 Aug;58(8):722-729

Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Klinikum der Universität München, LMU München, Marchioninistr. 15, 81377, München, Deutschland.

Clinical Issue: Gross tumor volume (GTV) denotes the macroscopic tumor which as the central target volume needs to be correctly identified for successful radiotherapy.

Standard Radiological Methods And Methodical Innovations: In precision radiotherapy, GTV is outlined on 3D tomographic images. The basis is computed tomography (CT), which is often supplemented by additional diagnostic information, e. Read More

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[Clinical target volume : Principles and limits].

Radiologe 2018 Aug;58(8):730-735

Universitätsklinik für Strahlentherapie, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Deutschland.

Background: The clinical target volume (CTV) is regarded fundamental for radiotherapy planning by the International Commission on Radiation Units and Measurements (ICRU).

Objectives: The aim of this article is to give an overview on the basics and problems of defining the CTV for radiotherapy planning.

Materials And Methods: After briefly defining CTV, a short description of the process to homogenize CTV in intraindividual comparisons is given, where special attention is paid to radiological requirements. Read More

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[Planning target volume : Management of uncertainties, immobilization, image guided and adaptive radiation therapy].

Radiologe 2018 Aug;58(8):736-745

Abteilung Medizinische Physik in der Strahlentherapie, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland.

Clinical/methodical Issue: As a standard, today's radiation therapy is based on CT images which are used for therapy planning. These images are obtained once before therapy starts and serve as a basis to obtain the position and shape of the target volume. As the patient has to be positioned anew for each fraction, deviations of the tumor position relative to the radiation field but also internal motion of the tumor may occur. Read More

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Significance of intra-fractional motion for pancreatic patients treated with charged particles.

Radiat Oncol 2018 Jun 25;13(1):120. Epub 2018 Jun 25.

Heidelberg Ion-Beam Therapy Center, Heidelberg, Germany.

Background: Uncertainties associated with the delivery of treatment to moving organs might compromise the accuracy of treatment. This study explores the impact of intra-fractional anatomical changes in pancreatic patients treated with charged particles delivered using a scanning beam. The aim of this paper is to define the potential source of uncertainties, quantify their effect, and to define clinically feasible strategies to reduce them. Read More

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June 2018
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[Lung Resection after Definitive and Neo-Adjuvant Chemoradiation for Stage IIIA/B Locally Advanced Non-Small Cell Lung Cancer: a Retrospective Analysis].

Zentralbl Chir 2018 Jun 22;143(3):307-315. Epub 2018 Jun 22.

Thoraxchirurgische Abteilung in der Chirurgischen Klinik, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Deutschland.

Background: The outcomes of so called "salvage" resections after definitive chemoradiation vs. curative resections after neoadjuvant chemoradiation therapy (IT-resection) in patients with stage IIIA/B locally advanced non-small cell lung cancer have rarely been compared. The aim of our study was to compare perioperative results, postoperative and recurrence-free survival and to identify relevant prognostic survival factors for both therapy strategies. Read More

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June 2018
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A new reference-type ionization chamber with direction-independent response for use in small-field photon-beam dosimetry - An experimental and Monte Carlo study.

Z Med Phys 2018 Jun 4. Epub 2018 Jun 4.

University Clinic for Medical Radiation Physics, Medical Campus Pius Hospital, Carl von Ossietzky University, Oldenburg, Germany.

The frequently applied narrow and non-standard transverse dose profiles of intensity modulated photon-beam radiotherapy, lacking lateral secondary electron equilibrium, require the use of high-resolution dosimetry detectors, and small air-filled detectors are recommended as the reference detectors for cross-calibration of the high-resolution detectors. The present study focuses on the dosimetric properties of a novel cylindrical ionization chamber, the PTW Semiflex 3D 31021. The chamber's effective point of measurement was found to lie at (0. Read More

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June 2018
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