4,603 results match your criteria Strahlentherapie und Onkologie[Journal]


[Whole- or partial-breast radiotherapy after 5 years from a patient perspective: longitudinal analysis of the IMPORT LOW (CRUK/06/003) phase III trial].

Strahlenther Onkol 2019 Apr 18. Epub 2019 Apr 18.

Klinik für Strahlentherapie, Campus Kiel, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01472-3DOI Listing

[Vitamin D and omega-3 fatty acid supplementation does not reduce the cancer and cardiovascular risk].

Authors:
Florian Lordick

Strahlenther Onkol 2019 Apr 18. Epub 2019 Apr 18.

Universitäres Krebszentrum Leipzig (UCCL), 1. Medizinische Klinik (Hämatologie, Zelltherapie, Internistische Onkologie, Hämostaseologie), Universitätsmedizin Leipzig, Liebigstraße 22 (Haus 7), 04103, Leipzig, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01455-4DOI Listing

The impact of vaginal dilator use on vaginal stenosis and sexual quality of life in women treated with adjuvant radiotherapy for endometrial cancer.

Strahlenther Onkol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Despite a lack of evidence and low compliance, current guidelines recommend the use of a vaginal dilator (VD) after pelvic radiotherapy (RT). We analyzed the effect of VD on vaginal stenosis (VS) and its influence on sexual quality of life (QoL) in women treated with adjuvant RT for endometrial cancer (EC).

Methods: Between 2014 and 2015, 56 consecutive patients were instructed to use a VD after completion of treatment. Read More

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http://dx.doi.org/10.1007/s00066-019-01466-1DOI Listing

Influence of XRCC4 expression by breast cancer cells on ipsilateral recurrence after breast-conserving therapy.

Strahlenther Onkol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Sapporo Medical University School of Medicine, 060-8543, Chuo-ku, Sapporo, Hokkaido, Japan.

Background: We examined the expression of nonhomologous end-joining (NHEJ) proteins by breast cancer cells in patients with or without ipsilateral breast tumor recurrence (IBTR) after breast-conserving therapy. We also investigated whether there was a difference of NHEJ-related protein expression by tumor cells between two types of IBTR, i.e. Read More

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http://link.springer.com/10.1007/s00066-019-01468-z
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http://dx.doi.org/10.1007/s00066-019-01468-zDOI Listing
April 2019
2 Reads

Acute severe lymphopenia by radiotherapy is associated with reduced overall survival in hepatocellular carcinoma.

Strahlenther Onkol 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, 03722, Seodaemun-gu, Seoul, Korea (Republic of).

Purpose: Radiotherapy (RT) for peripheral organs can affect circulating lymphocytes and cause lymphopenia. We aimed to investigate RT-related lymphopenia in patients with hepatocellular carcinoma (HCC).

Methods: Medical records of 920 patients who received RT for HCC during 2001-2016 were reviewed. Read More

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http://dx.doi.org/10.1007/s00066-019-01462-5DOI Listing

Retroperitoneal soft tissue sarcoma: low-dose neoadjuvant radiation therapy followed by surgery with or without intraoperative radiotherapy and adjuvant radiation therapy.

Strahlenther Onkol 2019 Apr 10. Epub 2019 Apr 10.

Department of Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Straße 6, 79106, Freiburg, Germany.

Background: We describe the clinical history, outcome, and toxicity of five patients with high-grade retroperitoneal soft tissue sarcoma (RSTS) who were treated with neoadjuvant low-dose radiotherapy (RT) followed by resection with or without intraoperative radiotherapy (IORT), followed by adjuvant RT. We aim to provide additional evidence for the various treatment options that exist for this rare tumor entity.

Methods: Most patients presented with mild abdominal symptoms. Read More

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http://dx.doi.org/10.1007/s00066-019-01464-3DOI Listing
April 2019
2 Reads

Consolidative mediastinal irradiation of malignant lymphoma using active scanning proton beams: clinical outcome and dosimetric comparison.

Strahlenther Onkol 2019 Apr 10. Epub 2019 Apr 10.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Current research approaches in lymphoma focus on reduction of therapy-associated long-term side effects. Especially in mediastinal lymphoma, proton beam radiotherapy (PT) may be a promising approach for reducing the dose to organs at risk (OAR).

Patients: In total, 20 patients were irradiated with active scanning PT at Heidelberg Ion Beam Therapy Center (HIT) between September 2014 and February 2017. Read More

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http://dx.doi.org/10.1007/s00066-019-01460-7DOI Listing
April 2019
2 Reads

Adapted strategy to tumor response in childhood nasopharyngeal carcinoma: the French experience.

Strahlenther Onkol 2019 Apr 8. Epub 2019 Apr 8.

SIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with cancer), PSL Research University, French Pediatric Rare Tumor group (Fracture group), Institut Curie, 26, rue d'Ulm, 75005, Paris, France.

Purpose: The aim of this study was to retrospectively study survival and long-term morbidities of children with nasopharyngeal carcinoma (NPC) treated by induction chemotherapy and concurrent chemoradiation (CRT). The total dose of radiation was adapted to the response following neoadjuvant chemotherapy.

Methods: Children with non-metastatic NPC treated in France between 1999 and 2015 were retrospectively included in the study. Read More

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http://dx.doi.org/10.1007/s00066-019-01461-6DOI Listing
April 2019
1 Read

Reply to: Combination of brachytherapy and chemotherapy not superior to pelvic radiotherapy according to GOG-249.

Authors:
S Marnitz

Strahlenther Onkol 2019 Apr 5. Epub 2019 Apr 5.

Medical Faculty, Department of Radiation Oncology, CyberKnife- and Radiation Therapy, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1007/s00066-019-01453-6DOI Listing

[Radiosurgery and surgical neurovascular decompression are almost equal for treatment of trigeminal neuralgia].

Strahlenther Onkol 2019 Apr 4. Epub 2019 Apr 4.

Klinik für Strahlentherapie und RadioOnkologie des Klinikums rechts der Isar, Technische Universität München (TUM), Ismaninger Straße 22, 81675, München, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01454-5DOI Listing

[Durvalumab after chemoradiotherapy is currently the most promising treatment for stage III NSCLC].

Authors:
Martin Wilhelm

Strahlenther Onkol 2019 Apr 4. Epub 2019 Apr 4.

Universitätsklinik für Innere Medizin 5, Klinikum Nürnberg, Paracelsus Medizinische Privatuniversität, Prof.-Ernst-Nathan-Str. 1, 90419, Nürnberg, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01456-3DOI Listing
April 2019
1 Read

Re-irradiation in locally recurrent lung cancer patients.

Strahlenther Onkol 2019 Apr 1. Epub 2019 Apr 1.

University Hospital of Heidelberg, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Lung cancer remains one of the tumour diagnoses with high lethality, although innovative treatment approaches have yielded improvements in local control and survival rates. There is still no consensus on how to treat local relapse in patients after first-line treatments. Radiotherapy may be considered in this situation; however, data supporting its effectiveness are rare. Read More

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http://dx.doi.org/10.1007/s00066-019-01457-2DOI Listing

Chemoradiotherapy for anal cancer: are we as good as we think?

Strahlenther Onkol 2019 Apr 1. Epub 2019 Apr 1.

Department of Radiotherapy and Oncology, Goethe-University Frankfurt am Main, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Definitive chemoradiotherapy (CRT) is the standard treatment for anal squamous cell carcinoma (ASCC). Data regarding treatment outcome according to TNM classification is scarce. Here, we review data of randomized trials and retrospective cohorts suggesting a poor 3‑year disease-free survival (DFS; or progression-free survival, PFS) of approximately 60%, or even lower, in patients with locally advanced T3-4 and/or N+ disease, while patients with T1-2N0 ASCC have 3‑year DFS/PFS rates exceeding 80%. Read More

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http://link.springer.com/10.1007/s00066-019-01444-7
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http://dx.doi.org/10.1007/s00066-019-01444-7DOI Listing
April 2019
1 Read

Tomotherapy in malignant mesothelioma: a planning study to establish dose constraints.

Strahlenther Onkol 2019 Mar 26. Epub 2019 Mar 26.

Radiologische Klinik, FE Strahlentherapie, Universitätsklinik Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

Purpose: A planning study was performed for helical tomotherapy treatment. We evaluated the maximum achievable protection of organs at risk (OARs) in patients with malignant pleural mesothelioma after pleurectomy with simultaneous optimal target coverage.

Materials And Methods: The datasets of 13 patients were included. Read More

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http://dx.doi.org/10.1007/s00066-019-01458-1DOI Listing
March 2019
3 Reads

Definitive radiochemotherapy or initial surgery for oropharyngeal cancer : To what extent can p16 expression be used in the decision process?

Strahlenther Onkol 2019 Mar 15. Epub 2019 Mar 15.

Radiation Oncology Department, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse, 1 avenue Irène Joliot-Curie, Cedex 9, 31059, Toulouse, France.

Background: The decision between definitive radio(chemo)therapy (RCT) or a surgical strategy, i. e. surgery ± adjuvant radio(chemo)therapy for optimal treatment of oropharyngeal cancer is highly debated. Read More

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http://dx.doi.org/10.1007/s00066-019-01451-8DOI Listing
March 2019
2 Reads

Time course of pain response and toxicity after whole-nerve-encompassing LINAC-based stereotactic radiosurgery for trigeminal neuralgia-a prospective observational study.

Strahlenther Onkol 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiation Oncology, Friedrich-Alexander-University Erlangen-Nuremberg, Universitaetsstraße 27, 91054, Erlangen, Germany.

Purpose: To prospectively evaluate the time course of pain response and toxicity after linear accelerator-based whole-nerve-encompassing radiosurgery (LINAC-SRS) using a uniform treatment schedule for dosing and target volume definition in patients with refractory trigeminal neuralgia.

Methods: From December 2012 to December 2016, 21 patients were treated using a standardized protocol. Patients received LINAC-SRS with 70 Gy to the cisternal portion while aiming for the 90% isodose to fully envelope the nerve in one cross-sectional plane. Read More

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http://dx.doi.org/10.1007/s00066-019-01450-9DOI Listing
March 2019
1 Read

Radiomic analysis of planning computed tomograms for predicting radiation-induced lung injury and outcome in lung cancer patients treated with robotic stereotactic body radiation therapy.

Strahlenther Onkol 2019 Mar 15. Epub 2019 Mar 15.

Department of Stereotactic and Functional Neurosurgery, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Objectives: To predict radiation-induced lung injury and outcome in non-small cell lung cancer (NSCLC) patients treated with robotic stereotactic body radiation therapy (SBRT) from radiomic features of the primary tumor.

Methods: In all, 110 patients with primary stage I/IIa NSCLC were analyzed for local control (LC), disease-free survival (DFS), overall survival (OS) and development of local lung injury up to fibrosis (LF). First-order (histogram), second-order (GLCM, Gray Level Co-occurrence Matrix) and shape-related radiomic features were determined from the unprocessed or filtered planning CT images of the gross tumor volume (GTV), subjected to LASSO (Least Absolute Shrinkage and Selection Operator) regularization and used to construct continuous and dichotomous risk scores for each endpoint. Read More

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http://dx.doi.org/10.1007/s00066-019-01452-7DOI Listing
March 2019
2 Reads

[Lateral pelvic lymph nodes in locally advanced rectal carcinoma-an underestimated site of recurrence?>].

Strahlenther Onkol 2019 Mar 11. Epub 2019 Mar 11.

Klinik für Radioonkologie, Universitätsklinik Tübingen, 72076, Tübingen, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01447-4DOI Listing
March 2019
1 Read

Favorable radiation field decrease in gastric marginal zone lymphoma : Experience of the German Study Group on Gastrointestinal Lymphoma (DSGL).

Strahlenther Onkol 2019 Mar 11. Epub 2019 Mar 11.

Department of Radiation Oncology, University Hospital of Münster, Building A1, Albert Schweitzer Campus 1, 48149, Münster, Germany.

Purpose: Long-term impact of stage-adapted field reduction in a large cohort of gastric marginal zone lymphoma (gMZL) patients treated conservatively with curative radiation therapy (RT).

Patients And Methods: Prospective analysis of paper records of 290 patients with stage IE-IIE gMZL, treated in 78 radiotherapeutic institutions in Germany from 1992-2013. Stage-adapted radiation fields decreased from extended field (EF) to involved field (IF) over the course of three consecutive prospective trials of the German Study Group on Gastrointestinal Lymphoma (DSGL). Read More

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http://dx.doi.org/10.1007/s00066-019-01446-5DOI Listing
March 2019
1 Read

[FOLFIRINOX after resection of pancreatic cancer sets new standards-systemic therapy providing an impulse for local treatment in resectable pancreatic cancer].

Strahlenther Onkol 2019 Mar 7. Epub 2019 Mar 7.

Strahlenklinik Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01449-2DOI Listing

[Universal genetic testing to combat underdiagnosis of hereditary breast cancer].

Strahlenther Onkol 2019 Mar 7. Epub 2019 Mar 7.

Klinik für Strahlentherapie und Radioonkologie, Universitätsklinikum, Friedrich-Schiller-Universität, Bachstr. 18, 07745, Jena, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01448-3DOI Listing

Rectal retractor application during image-guided dose-escalated prostate radiotherapy.

Strahlenther Onkol 2019 Mar 1. Epub 2019 Mar 1.

Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To investigate efficacy of a rectal retractor (RR) on rectal dose during image-guided dose-escalated prostate three-dimensional conformal radiotherapy (3DCRT).

Patients And Methods: In all, 21 patients with localized prostate cancer were treated with a RR for 3DCRT in 40 × 2 Gy. Patient underwent two scans for radiotherapy planning, without and with RR. Read More

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http://dx.doi.org/10.1007/s00066-019-01445-6DOI Listing
March 2019
5 Reads

[Endocrine deficiency after radiotherapy of brain tumors in children and young adults].

Strahlenther Onkol 2019 Feb 26. Epub 2019 Feb 26.

Klinik für Strahlentherapie und RadioOnkologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01442-9DOI Listing
February 2019

Single-center long-term results from the randomized phase-3 TARGIT-A trial comparing intraoperative and whole-breast radiation therapy for early breast cancer.

Strahlenther Onkol 2019 Feb 22. Epub 2019 Feb 22.

Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Purpose: Partial breast irradiation using intraoperative radiotherapy (IORT) after breast-conserving surgery could be sufficient for a selected group of breast cancer patients. We report the results of a cohort of patients from a single center treated as part of the randomized phase-3 TARGIT-A trial.

Methods: Patients (≥50 years) with cT1 cN0 cM0 and invasive ductal histology on biopsy were randomized between IORT with 20 Gy (arm-A) or postoperative whole-breast RT (WBRT) up to 56 Gy in 2 Gy fractions (arm-B). Read More

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http://dx.doi.org/10.1007/s00066-019-01438-5DOI Listing
February 2019
1 Read

Adjuvant radiochemotherapy vs. chemotherapy alone in gastric cancer: a meta-analysis.

Strahlenther Onkol 2019 Feb 22. Epub 2019 Feb 22.

Department of Radiation Oncology, Heinrich Heine University, Moorenstr. 5, 40225, Dusseldorf, Germany.

Background: As an adjuvant therapeutic strategy in advanced gastric cancer, both adjuvant chemotherapy (CTx) and postoperative radiochemotherapy (RCTx) can be considered. Both approaches have been shown to improve overall survival compared to resection alone. Several prospective randomized trials have compared the two postoperative concepts. Read More

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http://dx.doi.org/10.1007/s00066-019-01431-yDOI Listing
February 2019

[Impact of prophylactic cranial irradiation on overall survival of patients with advanced non-small-cell lung cancer].

Strahlenther Onkol 2019 Feb 21. Epub 2019 Feb 21.

Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Medizinische Fakultät, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01443-8DOI Listing
February 2019
2 Reads

[In HPV-associated oropharyngeal cancer, chemoradiotherapy with cisplatin is superior to bioradiotherapy with cetuximab in terms of overall survival].

Authors:
Sabine Semrau

Strahlenther Onkol 2019 Feb 21. Epub 2019 Feb 21.

Universitäts-Strahlenklinik, Universitätsstraße 27, 91054, Erlangen, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01441-wDOI Listing
February 2019

Combination of brachytherapy and chemotherapy not superior to pelvic radiotherapy according to GOG-249.

Strahlenther Onkol 2019 Feb 18. Epub 2019 Feb 18.

Clinic of Radiotherapy & Radiation Oncology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00066-019-01439-4DOI Listing
February 2019

[Management of immunological adverse events in patients treated with immune checkpoint inhibitors: ASCO clinical practice guideline summary].

Authors:
Mechthild Krause

Strahlenther Onkol 2019 Apr;195(4):365-366

Klinik für Strahlentherapie, Universitätsklinikum Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01436-7DOI Listing

[Local radiotherapy for patients with newly diagnosed, metastatic prostate cancer].

Strahlenther Onkol 2019 Apr;195(4):362-364

Department of Radiation Oncology, Competence Center Palliative Care, University Hospital Zurich (USZ), Rämistrasse 100, 8091, Zurich, Schweiz.

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http://dx.doi.org/10.1007/s00066-019-01435-8DOI Listing
April 2019
1 Read

[Patients with metastatic spinal cord compression profit from rapid multidisciplinary diagnostics and treatment].

Authors:
Carsten Nieder

Strahlenther Onkol 2019 Apr;195(4):367-368

Nordland Hospital Trust, 8092, Bodø, Norwegen.

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http://dx.doi.org/10.1007/s00066-019-01437-6DOI Listing

Reply to the letter to the editor "Comment to 'Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials'".

Strahlenther Onkol 2019 Apr;195(4):308-309

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

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http://dx.doi.org/10.1007/s00066-019-01433-wDOI Listing
April 2019
2.914 Impact Factor

Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study.

Strahlenther Onkol 2019 Apr 11;195(4):352-361. Epub 2019 Feb 11.

Radiation Immuno-Oncology, Center for Translational Cancer Research TUM (TranslaTUM), Einsteinstr. 25, 81675, Munich, Germany.

Background: Membrane heat shock protein 70 (mHsp70) is indicative of high-risk tumors and serves as a tumor-specific target for natural killer (NK) cells stimulated with Hsp70 peptide (TKD) and Interleukin(IL)-2. Radiochemotherapy (RCT), mHsp70-targeting NK cells, and programmed death(PD)-1 inhibition were combined to improve the efficacy of tumor-specific immune cells in a non-small cell lung carcinoma (NSCLC) patient.

Patient: Following simultaneous RCT (64. Read More

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http://link.springer.com/10.1007/s00066-019-01434-9
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http://dx.doi.org/10.1007/s00066-019-01434-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433810PMC
April 2019
2 Reads

The value of pretreatment serum butyrylcholinesterase level as a novel prognostic biomarker in patients with cervical cancer treated with primary (chemo-)radiation therapy.

Strahlenther Onkol 2019 Feb 8. Epub 2019 Feb 8.

Department for Gynecology and Gynecologic Oncology, Gynecologic Cancer Unit, Comprehensive Cancer Centre, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Deficiency in butyrylcholinesterase (BChE), a condition commonly noticed in liver damage, inflammation, and malnutrition, has previously been associated with impaired prognosis in different malignancies. The aim of the present study was to investigate the value of pretreatment serum BChE levels as a prognostic biomarker in patients with cervical cancer treated with primary (chemotherapy-[chemo-])radiation therapy.

Methods: We retrospectively evaluated data of a consecutive series of patients with cervical cancer treated with primary (chemo-)radiation therapy between 1998 and 2015. Read More

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http://dx.doi.org/10.1007/s00066-019-01430-zDOI Listing
February 2019
1 Read

Combination of stereotactic radiotherapy and targeted therapy: patterns-of-care survey in German-speaking countries.

Strahlenther Onkol 2019 Mar 8;195(3):199-206. Epub 2019 Feb 8.

Department of Radiation Oncology, University Hospital Zurich, Rämistrasse 100, 8091, Zürich, Switzerland.

Introduction: Stereotactic body radiotherapy (SBRT) is increasingly used in metastasized patients receiving targeted/immunotherapy. Information on safety and effectivity of concurrent SBRT and targeted/immunotherapy remains limited, resulting in a lack of consensus on treatment strategies. This study aimed to investigate how SBRT-experienced centers in German-speaking countries combine both therapies. Read More

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http://dx.doi.org/10.1007/s00066-018-01422-5DOI Listing

Outcome of loco-regional radiotherapy in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate.

Strahlenther Onkol 2019 Jan 30. Epub 2019 Jan 30.

Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: To evaluate the potential benefit of curative radiotherapy (RT) to the primary tumor in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone.

Materials And Methods: The clinical parameters of 106 mCRPC patients treated with abiraterone were retrospectively evaluated. Patients were either oligometastatic (≤5 metastases) at diagnosis or became oligometastatic after the systemic treatment was analyzed. Read More

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http://dx.doi.org/10.1007/s00066-019-01429-6DOI Listing
January 2019
3 Reads

Risk of cardiotoxicity induced by adjuvant anthracycline-based chemotherapy and radiotherapy in young and old Asian women with breast cancer.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China.

Purpose: The risk of cardiotoxicity induced by adjuvant anthracycline-based chemotherapy (CT) and radiotherapy (RT) is yet to be investigated in a large-scale randomized controlled trial with an adequate sample size of young and old women with breast cancer.

Patients And Methods: To compare the occurrence of major heart events (heart failure and coronary artery disease) in patients with breast cancer, 3489 women who underwent surgical resection of the breast tumor were retrospectively selected from the Taiwan National Health Insurance Research Database. The patients were categorized into the following groups based on their treatment modalities: group 1 (n = 1113), no treatment; group 2 (n = 646), adjuvant RT alone; group 3 (n = 705), adjuvant anthracycline-based CT alone; and group 4 (n = 1025), combined adjuvant RT and anthracycline-based CT. Read More

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http://dx.doi.org/10.1007/s00066-019-01428-7DOI Listing
January 2019
1 Read

[Reduced radiation-induced brain necrosis in nasopharyngeal cancer patients with bevacizumab monotherapy].

Strahlenther Onkol 2019 Mar;195(3):277-280

Klinik für Strahlentherapie & Ambulanzzentrum Strahlentherapie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01425-wDOI Listing

[Impact of surgical approach on prognosis in early-stage cervical cancer].

Strahlenther Onkol 2019 Mar;195(3):274-276

MVZ im Fürstenberg-Karree, Institut für Zytologie Dysplasie, Hohenzollerndamm 123, 14199, Berlin, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01426-9DOI Listing

Heparin treatment mitigates radiation-induced oral mucositis in mice by interplaying with repopulation processes.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiation Oncology-ATRAB-Applied and Translational Radiobiology, Department of Radiation Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Purpose: To investigate the mechanistic background of the muco-protective effect of systemic heparin treatment on the development of radiation-induced oral mucositis in mice.

Materials And Methods: Fractionated irradiation was given to the snouts of male C3H/Neu mice over 2 weeks (10 × 3 Gy), either alone or in combination with daily subcutaneous application of unfractionated or low molecular weight heparin (40 or 200 I.U. Read More

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http://dx.doi.org/10.1007/s00066-018-01423-4DOI Listing
January 2019

Radiotherapy-induced dysphagia and its impact on quality of life in patients with nasopharyngeal carcinoma.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, 510120, Guangzhou, Guangdong Province, China.

Purpose: To investigate the swallowing status and its impact on quality of life (QOL) in patients who underwent radiotherapy for nasopharyngeal carcinoma (NPC).

Methods: In this study, 334 patients with NPC who underwent radiotherapy were reviewed. Clinical characteristics, videofluoroscopic swallowing studies (VFSSs), and scores of the World Health Organization quality of life-BREF (WHOQOL-BREF) were retrospectively analyzed for all patients. Read More

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http://dx.doi.org/10.1007/s00066-018-01421-6DOI Listing
January 2019
2 Reads

Stereotactic body radiotherapy of central lung malignancies using a simultaneous integrated protection approach : A prospective observational study.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Radiation Oncology, IRCCS, Sacro Cuore-Don Calabria Hospital, Negrar-Verona, Italy.

Aim: It is recognized that stereotactic body radiotherapy (SBRT) for centrally located lung metastases is affected by higher rates of severe toxicity. In the present study, we report the clinical outcomes following a novel intensity-modulated radiotherapy prescription dose, termed simultaneous integrated protection (SIP), for nearby organs at risk (OARs).

Materials And Methods: The prescribed total doses of SBRT were 70 Gy in 10 fractions and 60 Gy in 8 fractions. Read More

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http://dx.doi.org/10.1007/s00066-018-01419-0DOI Listing
January 2019
1 Read

Clinical safety and efficacy of salvage reirradiation for upper abdominal malignancies.

Strahlenther Onkol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic of).

Purpose: Reirradiation has the potential to provide effective local control of upper abdominal malignancies. This study aimed to evaluate the safety and efficacy of reirradiation for upper abdominal malignancies.

Methods: A total of 42 patients with a history of prior radiotherapy (RT) received reirradiation for abdominal malignancies between 2005 and 2017. Read More

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http://dx.doi.org/10.1007/s00066-018-01420-7DOI Listing
January 2019
22 Reads

[The end of TPF induction for locally advanced head and neck cancer? Induction chemotherapy followed by cetuximab and radiotherapy is not superior to concurrent chemoradiotherapy].

Strahlenther Onkol 2019 Mar;195(3):281-284

Klinik für Strahlentherapie und Spezielle Onkologie, Medizinische Hochschule Hannover, Hannover, Deutschland.

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http://dx.doi.org/10.1007/s00066-019-01427-8DOI Listing
March 2019
2 Reads

ICRU report 91 on prescribing, recording, and reporting of stereotactic treatments with small photon beams : Statement from the DEGRO/DGMP working group stereotactic radiotherapy and radiosurgery.

Strahlenther Onkol 2019 Mar 16;195(3):193-198. Epub 2019 Jan 16.

Klinik für Strahlentherapie, Universitätsspital Zürich, Zürich, Switzerland.

The International Commission on Radiation Units and Measurements (ICRU) report 91 with the title "prescribing, recording, and reporting of stereotactic treatments with small photon beams" was published in 2017. This extensive publication covers different relevant aspects of stereotactic radiotherapy such as small field dosimetry, accuracy requirements for volume definition and planning algorithms, and the precise application of treatment by means of image guidance. Finally, recommendations for prescribing, recording and reporting are given. Read More

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http://link.springer.com/10.1007/s00066-018-1416-x
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http://dx.doi.org/10.1007/s00066-018-1416-xDOI Listing
March 2019
5 Reads

Predicting tumor responses and patient survival in chemoradiotherapy-treated patients with non-small-cell lung cancer using dynamic contrast-enhanced integrated magnetic resonance-positron-emission tomography.

Strahlenther Onkol 2019 Jan 4. Epub 2019 Jan 4.

Department of Medical Imaging, National Taiwan University Hospital, National Taiwan University College of Medicine, No.7, Chung-Shan South Road, 100, Taipei, Taiwan.

Purpose: We investigated whether radiologic parameters by dynamic contrast-enhanced (DCE) integrated magnetic resonance-positron-emission tomography (MR-PET) predicts tumor response to treatment and survival in non-metastatic non-small-cell lung cancer (NSCLC) patients receiving chemoradiotherapy (CRT).

Methods: Patients underwent DCE integrated MR-PET imaging 1 week before CRT. The following parameters were analyzed: primary tumor size, gross tumor volume, maximal standardized uptake value (SUV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC), volume transfer constant (K), reverse reflux rate constant (k), extracellular extravascular volume fraction (v), blood plasma volume fraction (v), and initial area under the time-concentration curve defined over the first 60 s post-enhancement (iAUC). Read More

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http://dx.doi.org/10.1007/s00066-018-1418-8DOI Listing
January 2019
2.914 Impact Factor

Is there a patient population with squamous cell carcinoma of the head and neck region who might benefit from de-intensification of postoperative radiotherapy? : A monocentric retrospective analysis of a previously defined low-risk patient population treated with standard-of-care radiotherapy.

Strahlenther Onkol 2019 Jan 4. Epub 2019 Jan 4.

Department of Radiation Oncology, University Hospital of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 27, 91054, Erlangen, Germany.

Purpose: The aim of this retrospective study was to evaluate the clinical outcome of a previously defined low-risk patient population with completely resected (R0) squamous cell carcinoma of the oral cavity, oropharynx, larynx (pT1-3, pN0-pN2b), hypopharynx (pT1-2, pN0-pN1), and the indication for postoperative radio(chemo)therapy.

Patients And Methods: According to predefined criteria, 99 patients with head and neck squamous cell carcinoma (SCC) who were treated at our institution from January 1, 2005 to December 31, 2014, were available for analysis. The Kaplan-Meier method was used for calculating survival and incidence rates. Read More

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http://dx.doi.org/10.1007/s00066-018-1415-yDOI Listing
January 2019
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Comparison of  Ga-PSMA ligand PET/CT versus conventional cross-sectional imaging for target volume delineation for metastasis-directed radiotherapy for metachronous lymph node metastases from prostate cancer.

Strahlenther Onkol 2019 Jan 4. Epub 2019 Jan 4.

Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To assess the differences in the target volume (TV) delineation of metachronous lymph node metastases between  Ga-PSMA ligand PET/CT and conventional imaging in a comparative retrospective contouring study.

Patients And Methods: Twenty-five patients with biochemical prostate cancer recurrence after primary prostatectomy underwent  Ga-PSMA ligand PET/CT in addition to conventional imaging techniques such as CT and/or MR imaging for restaging. All patients were diagnosed with at least one lymph node metastasis. Read More

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http://dx.doi.org/10.1007/s00066-018-1417-9DOI Listing
January 2019
6 Reads

Comment to Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials.

Strahlenther Onkol 2019 Apr;195(4):306-307

Klinik für RadioOnkologie und Strahlentherapie, St. Marienkrankenhaus Siegen, 57072, Siegen, Germany.

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http://dx.doi.org/10.1007/s00066-018-1411-2DOI Listing
April 2019
4 Reads

Hyperthermic chest wall re-irradiation in recurrent breast cancer: a prospective observational study.

Strahlenther Onkol 2019 Apr 3;195(4):318-326. Epub 2019 Jan 3.

Department of Radiation Oncology, University Hospital and Medical Faculty Tübingen, Eberhard Karls University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Purpose: To prospectively investigate the role of re-irradiation (re-RT) combined with hyperthermia (HT) in a contemporary cohort of patients affected by recurrent breast cancer (RBC).

Methods: Within the prospective registry HT03, patients with resected RBC and previous irradiation were included. Re-RT was applied to the recurrence region with doses of 50-50. Read More

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http://link.springer.com/10.1007/s00066-018-1414-z
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http://dx.doi.org/10.1007/s00066-018-1414-zDOI Listing
April 2019
2 Reads