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Rev Esp Med Nucl Imagen Mol (Engl Ed) 2022 Jul-Aug;41(4):258-260. Epub 2021 Apr 15.

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Department of Nuclear Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Fujian, 361015, China; Nuclear Medicine Institute of Fudan University, Shanghai, 200032, China; Shanghai Institute of Medical Imaging, Shanghai, 200032, China. Electronic address:

Epidemiol Health 2022 Jun 21:e2022053. Epub 2022 Jun 21.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

Objectives: The COVID-19 pandemic has affected the utilization of healthcare services, such as participation in cancer screening programs. We compared cancer screening participation rates for colorectal, gastric, breast, and cervical cancers among participants in the National Cancer Screening Program (NCSP) in 2019 and 2020 to address the potential distraction effect of COVID-19 on cancer screening.

Methods: Data from the NCSP for four cancer types (stomach, colorectal, breast and cervical) in 2019 and 2020 were used to calculate cancer screening participation rates by calendar month, gender, age group, and geographical region. Read More

J Surg Res 2022 Jun 24;279:119-126. Epub 2022 Jun 24.

Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California; Department of Bioengineering, Stanford University, Stanford, California. Electronic address:

Introduction: Currently, there is no accurate noninvasive measurement system to diagnose gastrointestinal (GI) motility disorders. Wireless skin patches have been introduced to provide an accurate noninvasive measurement of GI myoelectric activity which is essential for developing neuro-stimulation devices to treat GI motility disorders. The aim of this study is to compare the external and internal electrical signal measurements in ambulatory pigs. Read More

ESMO Open 2022 Jun 24;7(4):100519. Epub 2022 Jun 24.

Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria. Electronic address:

Background: Gastroesophageal adenocarcinoma is a major contributor to global disease burden with poor prognosis even in resectable, regionally limited stages. Feasible prognostic tools are crucial to improve patient management, yet scarce.

Patients And Methods: Disease-related symptoms, patient, tumour, treatment as well as laboratory parameters at initial diagnosis and overall survival (OS) of patients with stage II and III gastroesophageal adenocarcinoma, who were treated between 1990 and 2020 at the Medical University of Vienna, were evaluated in a cross-validation model to develop a feasible risk prediction score. Read More

J Comput Assist Tomogr 2022 Jun 28. Epub 2022 Jun 28.

From the Department of Abdominal Radiology, The University of Texas MD Anderson Cancer Center.

Abstract: Also referred to as "osteoclast-rich, clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT)," malignant gastrointestinal neuroectodermal tumor is a newly described, rare, aggressive sarcoma that commonly arises in the small bowel, stomach, and colon. Histogenesis is likely from an autonomous nervous system-related primitive cell of neural crest origin. The hallmark genetic finding of EWS-CREB1 or EWS-ATF1 fusion transcripts clinches the diagnosis. Read More

Mol Pharm 2022 Jun 27. Epub 2022 Jun 27.

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Gastrointestinal anatomical/physiological changes after bariatric surgery influence variables affecting the fate of drugs after ingestion, and medication management of these patients requires a thorough and complex mechanistic analysis. The aim of this research was to study whether loratadine/desloratadine antiallergic treatment of bariatric patients is at risk of being ineffective due to impaired solubility/dissolution. The pH-dependent solubility of loratadine/desloratadine was studied in vitro, as well as ex vivo, in gastric content aspirated from patients before versus after bariatric surgery. Read More

Antimicrob Agents Chemother 2022 Jun 27:e0007322. Epub 2022 Jun 27.

Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting, Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.

Metronidazole (Met) is the first choice for treating Helicobacter pylori (). However, is easy to resistant, making Met unable to be widely used. How to overcome 's Met resistance is still an issue. Read More

Drug Des Devel Ther 2022 20;16:1947-1961. Epub 2022 Jun 20.

Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People's Republic of China.

Purpose: This study was designed to evaluate the pharmacological mechanisms of Aloin against gastric cancer (GC) via network pharmacology analysis combined with experimental verification.

Methods: Using network pharmacology methods, the potential targets of Aloin and targets related to GC were screened from public databases. The protein-protein interaction (PPI) network, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed to predict the core targets and pathways of Aloin against GC. Read More

Front Oncol 2022 8;12:910792. Epub 2022 Jun 8.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands.

Purpose: To determine the dosimetric impact of using unedited autocontours in daily plan adaptation of patients with locally advanced pancreatic cancer (LAPC) treated with stereotactic body radiotherapy using tumor tracking.

Materials And Methods: The study included 98 daily CT scans of 35 LAPC patients. All scans were manually contoured (MAN), and included the PTV and main organs-at-risk (OAR): stomach, duodenum and bowel. Read More

Gastroenterol Res Pract 2022 15;2022:2040792. Epub 2022 Jun 15.

The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan.

Materials And Methods: This was a retrospective cohort study conducted in two municipal hospitals. We identified 24 patients with SNADETs of 3-18 mm in diameter who underwent UEMR or GIEMR. One lesion was excluded from the analysis because it was found to be in the stomach after surgery. Read More

Front Mol Biosci 2022 8;9:866408. Epub 2022 Jun 8.

Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.

Endothelial-to-mesenchymal transition (EndMT) is poorly understood in digestive diseases, and the function of metabolism in EndMT is uncertain. The goal of this study is to elucidate the role of EndMT in digestive diseases and to describe its metabolic state. The GEO database was used to extract single-cell data in order to discover EndMT subpopulations in digestive organs such as premalignant lesions and cancer of the stomach, intestine, and pancreas. Read More

Case Rep Psychiatry 2022 15;2022:5949321. Epub 2022 Jun 15.

North Shore University Hospital, A Division of Zucker-Hillside Department of Psychiatry, Northwell Health, Inc, USA.

A 36-year-old Hispanic female patient with gastrointestinal symptoms and weight loss was found to have a trichobezoar in her stomach requiring a surgical removal. Psychiatry team was consulted due to concerns for depression and trichotillomania. The psychiatric evaluation revealed that the patient was not ingesting her own hair - the most common instance in cases of trichotillomania and trichophagia, but her daughter's hair. Read More

Evid Based Complement Alternat Med 2022 17;2022:1046712. Epub 2022 Jun 17.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, No. 232, Waihuandong Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.

Objective: The present study aimed at the anti-inflammatory and antioxidant effects of the extract of fruit (BGF) on the gastric injury.

Materials And Methods: The chemical components in the extract of BGF were used in UPLC/Q-Orbitrap analysis. 60 SD rats were randomized into six groups: normal group (MC), ethanol-injured control group (EC), omeprazole group, and three groups with different doses (50, 100, and 200 mg/kg) of BGF. Read More

Front Pharmacol 2022 9;13:908079. Epub 2022 Jun 9.

Department of Pharmacy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.

Digestive system tumours, including stomach, colon, esophagus, liver and pancreatic tumours, are serious diseases affecting human health. Although surgical treatment and postoperative chemoradiotherapy effectively improve patient survival, current diagnostic and therapeutic strategies for digestive system tumours lack sensitivity and specificity. Moreover, the tumour's tolerance to drug therapy is enhanced owing to tumour cell heterogeneity. Read More

Antioxid Redox Signal 2022 Jun 25. Epub 2022 Jun 25.

University of California San Diego, 8784, Department of Medicine, La Jolla, California, United States;

Aims: While best known for its role in oxidative DNA damage repair, apurinic-apyrimidinic endonuclease-1 (APE1) is a multifunctional protein that regulates multiple host responses during oxidative stress including the reductive activation of transcription factors. As knockout of the APE1-encoding gene, , is embryonically lethal, we sought to create a viable model with generalized inhibition of APE1 expression.

Results: A hypomorphic mouse with decreased APE1 expression throughout the body was generated using a construct containing a cassette knocked into the site. Read More

Drugs Aging 2022 Jun 27. Epub 2022 Jun 27.

Department of Neurology, Boston University School of Medicine, Boston Medical Center, 85 E. Concord St, 1122, Boston, MA, 02118, USA.

As the population ages, spine-related pain is increasingly common in older adults. While medications play an important role in pain management, their use has limitations in geriatric patients due to reduced liver and renal function, comorbid medical problems, and polypharmacy. This review will assess the evidence basis for medications used for spine-related pain in older adults, with a focus on drug metabolism and adverse drug reactions. Read More

Int J Biol Macromol 2022 Jun 23. Epub 2022 Jun 23.

School of Food and Biological Engineering, Changsha University of Science & Technology, Changsha 410114, Hunan Province, China. Electronic address:

Structural evolution, digestibility and inhibition on starch digestion of rice glutelin fibril aggregates (RGFAs) as affected by incubation were investigated. Thioflavin T fluorescence intensity of the RGFAs, incubated for 4-day, reached the maximum values, which ranged from 845.00 ± 23. Read More

Dig Dis 2022 Jun 26. Epub 2022 Jun 26.

Introduction Glomus tumor is a rare mesenchymal neoplasm that can be found anywhere throughout the body, includ-ing the stomach. Our goal was to present a case and a systematic review of the literature, reporting clinical, radiological, surgical, and pathological features of the disease. Methods We reviewed Pubmed and SCOPUS for all case reports and case series published after 2000. Read More

World J Surg Oncol 2022 Jun 25;20(1):216. Epub 2022 Jun 25.

Department of Faculty Surgery №2, I.M.Sechenov First Moscow State Medical University, Moscow, Russia.

Background: Laparoscopic surgery has justified its efficacy in the treatment of early gastric cancer. There are limited data indicating the eligibility of laparoscopic interventions in locally advanced gastric cancer. Publications describing the safety of laparoscopic techniques in the treatment of local and metastatic gastric cancer complicated by bleeding and stenosis are scarce. Read More

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Rome, Italy. Electronic address:

Background: Surgical exploration remains the gold standard to evaluate the extension of disease and predict resectability. A laparoscopy-based scoring model was developed by Fagotti and colleagues in 2006 and updated in 2015, based on the intraoperative presence or absence of some specific cancer features. The model proved an overall accuracy rate of 77-100% and is considered the reference test to assess resectability in our Institution. Read More

Food Chem 2022 Jun 7;394:133410. Epub 2022 Jun 7.

Riddet Institute, Massey University, Private Bag 11222, Palmerston North, New Zealand; Department of Biological and Agricultural Engineering, University of California, Davis, CA 95618, USA. Electronic address:

How the stomach can serve as a biochemical environment for starch digestion and the implications on starch emptying are not well-understood. Biochemical changes during gastric digestion of cooked wheat- and rice-based diets of varying particle size and microstructure were investigated using a growing pig model. In larger-particle size diets (rice grain, rice noodle, pasta), pH >3 was maintained in the proximal stomach digesta even until 240 min digestion, resulting in extended remaining amylase activity and accumulation of maltose from starch hydrolysis in the stomach. Read More

J Epidemiol Glob Health 2022 Jun 25. Epub 2022 Jun 25.

School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.

Digestive tract cancers are the common cause of cancer deaths in both China and worldwide. This study aimed to describe the burden, recent trends and lifetime risks in the incidence and mortality of digestive tract cancers in an urban district of Shanghai, China. Our study extracted data on stomach, colon, rectum and liver cancers diagnosed in Changning District between 2010 and 2019 from the Shanghai Cancer Registry. Read More

Int J Cancer 2022 Jun 24. Epub 2022 Jun 24.

Department of Pathology, NYU School of Medicine, New York, New York, USA.

The incidence of esophageal adenocarcinoma (EA) has drastically increased in the United States since 1970s for unclear reasons. We hypothesized that the widespread usage of antibiotics has increased the procarcinogenic potential of the orodigestive microbiota along the sequence of gastroesophageal reflux (GR), Barrett's esophagus (BE), and EA phenotypes. This case control study included normal controls (NC) and three disease phenotypes GR, BE, and EA. Read More

J Pak Med Assoc 2022 Jun;72(6):1211-1213

Department of Pathology, Liaquat National Hospital, Karachi, Pakistan.

Gastric Schwannomas are rare, submucosal mesenchymal tumours arising from the nerve plexus of the Gut wall. They have an incidence rate of 0.2% of all Gastric tumours. Read More

Transplant Proc 2022 Jun 22. Epub 2022 Jun 22.

Faculty of Medical Sciences, Belo Horizonte, Minas Gerais, Brazil; IMUNOLAB - Laboratory of Histocompatibility, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Background: Malignancy is a well-known complication in patients after kidney transplantation (KT), but its effect on posttransplant outcomes, allograft, and patient survival remains unexplored. The aim of this study is to report the impact of the comorbidity on clinical outcome, function, and failure of an allograft kidney.

Methods: This case-control study included 101 KT patients. Read More

Int J Surg Case Rep 2022 Jun 20;96:107328. Epub 2022 Jun 20.

Department of General Surgery, Jendouba Hospital, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Introduction And Importance: Hiatal hernia (HH) contents commonly include stomach, transverse colon, small intestine, and spleen but herniation of the pancreas is an extremely rare phenomenon, even rarer when HH is associated with acute pancreatitis.

Case Presentation: A 56-year-old female with hypertension and gastroesophageal reflux disease presented with abdominal pain, vomiting and chest discomfort evolving for 24 h. Physical examination revealed left-upper quadrant tenderness without guarding. Read More

Environ Sci Technol 2022 Jun 24. Epub 2022 Jun 24.

Aix-Marseille University, Toulon University, CNRS, IRD, M I O, Marseille 13007, France.

Here, we evaluate for the first time the performances of the newly developed laser direct infrared (LDIR) technique and propose an optimization of the initial protocol for marine microplastics (MPs) analysis. Our results show that an 8 μm porosity polycarbonate filter placed on a Kevley slide enables preconcentration and efficient quantification of MPs, as well as polymer and size determination of reference plastic pellets of polypropylene (PP), polyethylene (PE), polystyrene (PS), polyvinyl chloride (PVC), and polyethylene terephthalate (PET), with recoveries ranging from 80-100% and negligible blank values for particle sizes ranging from 200 to 500 μm. A spiked experiment using seawater, sediment, mussels, and fish stomach samples showed that the method responded linearly with significant slopes ( ranging from 0. Read More

J Hepatobiliary Pancreat Sci 2022 Jun 24. Epub 2022 Jun 24.

Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China.

We presented a rare case of gastric adenocarcinoma with enteroblastic differentiation with pancreatic hepatoid adenocarcinoma metastasis. Tumors in the primitive site of the stomach and metastatic site in the pancreas demonstrated different morphological characteristics. Endoscopic-assisted tissue acquisition played a pivotal role in presurgical assessment, but may still trap in the pitfall in such a rare and obfuscated pathological case. Read More

J Gastrointest Cancer 2022 Jun 24. Epub 2022 Jun 24.

Department of Radiotherapy, All India Institute of Medical Sciences, Bhubaneswar, India.

Background: The incidence of perineural invasion (PNI) in patients with gastric cancer (GC) is high, and patients with PNI positive disease have a poor prognosis compared to PNI-negative disease. The present study aims to study the incidence and evaluate the impact of PNI on the survival outcome of a cohort of South Asian GC patients.

Material And Methods: All consecutive patients undergoing curative gastrectomy were included in the study. Read More

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Sección de Aparato Digestivo, Hospital General Universitario Reina Sofía, España.

Neuroendocrine tumors (NETs) or carcinoids represent a small percentage of gastrointestinal neoplasms (2%). The ileum (41.8%), rectum (27. Read More