269,259 results match your criteria Stomach


Stenting the Upper/Cervical Oesophagus with a Proximal Deployment Cervical Oesophageal Stent: Technique and Outcomes.

Cardiovasc Intervent Radiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Interventional Radiology, Maidstone and Tunbridge Wells NHS Trust, Maidstone Hospital, Hermitage Lane, Maidstone, Kent, ME16 9QQ, UK.

Introduction: Proximal oesophageal stent deployment continues to provide challenges due to the proximity of the upper oesophageal sphincter and the associated subsequent complications such as globus sensation and stent migration. Patients with cervical oesophageal cancer have previously had limited stenting options available to them with a paucity of the literature describing the radiological technique for successfully placing these high-risk stents. In this paper, we present our experience using the Taewoong Niti-S CERVICAL Oesophageal Stent. Read More

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http://dx.doi.org/10.1007/s00270-019-02201-0DOI Listing

A Bleeding Dieulafoy's Lesion in the Anal Canal.

Cureus 2019 Jan 8;11(1):e3853. Epub 2019 Jan 8.

Gatsroenterology, Staten Island University Hospital, Northwell Health, Staten Island, USA.

Dieulafoy's lesion (DL) is a dilated aberrant submucosal vessel that erodes through the overlying epithelium in the absence of a primary ulcer. It is a known cause of gastrointestinal (GI) bleeding and commonly located in the lesser curvature of the stomach, but it is rare in the anal canal. We report a unique case of a middle-aged man presenting with lower GI bleeding secondary to an anal DL diagnosed by colonoscopy, managed successfully with endoscopic hemoclips. Read More

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http://dx.doi.org/10.7759/cureus.3853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411322PMC
January 2019

Crohn's disease of esophagus, stomach and duodenum.

World J Gastrointest Pharmacol Ther 2019 Mar;10(2):35-49

Programa de Pós graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador 40110-060, Bahia, Brazil.

Crohn's disease with involvement of the esophagus, stomach and duodenum has a prevalence of 0.5% to 4% in symptomatic adult patients, but some studies have shown that these results may be underestimated, since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients, as it is in the pediatric population. In general, involvement of the upper gastrointestinal tract in Crohn's disease occurs concomitantly with involvement of the lower gastrointestinal tract. Read More

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http://dx.doi.org/10.4292/wjgpt.v10.i2.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422852PMC

Metabarcoding for stomach-content analyses of Pygmy devil ray (: Comparing tissue and ethanol preservative-derived DNA.

Ecol Evol 2019 Mar 1;9(5):2678-2687. Epub 2019 Feb 1.

School of Life and Environmental Sciences The University of Sydney Sydney New South Wales Australia.

The application of high-throughput sequencing to retrieve multi-taxon DNA from different substrates such as water, soil, and stomach contents has enabled species identification without prior knowledge of taxon compositions. Here we used three minibarcodes designed to target mitochondrial COI in plankton, 16S in fish, and 16S in crustaceans, to compare ethanol- and tissue-derived DNA extraction methodologies for metabarcoding. The stomach contents of pygmy devilrays ( cf. Read More

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http://dx.doi.org/10.1002/ece3.4934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405894PMC

Integrated transcriptome and in vitro analysis revealed anti-proliferative effect of citral in human stomach cancer through apoptosis.

Sci Rep 2019 Mar 19;9(1):4883. Epub 2019 Mar 19.

Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Yongin, 446- 701, Republic of Korea.

Cancer is the second leading cause of death globally, particularly stomach cancer is third most common causes of cancer death worldwide. Citral possesses anti-tumor activity in various cancer cell lines, However its effect toward stomach cancer and its mechanism of action is have yet to be elucidated. The goal of the present study is to elucidate the role of citral in stomach cancer using transcriptome and in vitro approaches. Read More

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http://dx.doi.org/10.1038/s41598-019-41406-8DOI Listing

VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection.

MBio 2019 Mar 19;10(2). Epub 2019 Mar 19.

Institute of Molecular Cancer Research, Zurich, Switzerland

The gastric bacterium causes a persistent infection that is directly responsible for gastric ulcers and gastric cancer in some patients and protective against allergic and other immunological disorders in others. The two outcomes of the -host interaction can be modeled in mice that are infected as immunocompetent adults and as neonates, respectively. Here, we have investigated the contribution of the immunomodulator VacA to -specific local and systemic immune responses in both models. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.00261-19
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http://dx.doi.org/10.1128/mBio.00261-19DOI Listing
March 2019
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The origin of p40-negative and CDX2-positive primary squamous cell carcinoma of the stomach: case report.

World J Surg Oncol 2019 Mar 19;17(1):53. Epub 2019 Mar 19.

Department of Surgery, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.

Background: Primary gastric squamous cell carcinoma (SCC) is a very rare disease. The origin of this tumor remains unclear, although there are some hypotheses. A 60-year-old man consulted a previous physician complaining of upper abdominal pain. Read More

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http://dx.doi.org/10.1186/s12957-019-1594-8DOI Listing

Sulfur-modified organoclay promotes plant uptake and affects geochemical fractionation of mercury in a polluted floodplain soil.

J Hazard Mater 2019 Mar 4;371:687-693. Epub 2019 Mar 4.

University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water- and Waste-Management, Laboratory of Soil- and Groundwater-Management, Pauluskirchstraße 7, 42285 Wuppertal, Germany; University of Sejong, Department of Environment, Energy and Geoinformatics, 98 Gunja-Dong, Guangjin-Gu, Seoul, Republic of Korea. Electronic address:

We investigated effects of the application of a sulfur-modified organoclay (SMOC) at doses of 1%, 3% and 5% (w/w) on the geochemical fractionation of mercury (Hg) and its accumulation by pea and corn in a polluted floodplain soil. Soil Hg was fractionated sequentially to five operationally defined fractions as follows: F1: water soluble Hg; F2: "human stomach acid" soluble Hg; F3: organo-chelated Hg; F4: elemental Hg; and F5: Hg-sulfur-compounds/residual Hg. The high dosage of SMOC caused a decrease of Hg in F3 (18%) and F5 (36-63%), and 6. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.03.010DOI Listing

Benefits of Robotic Camera Assistance in Minimally Invasive Bariatric Procedures: Prospective Clinical Trial Using a Joystick-Guided Camera-Holder.

Surg Technol Int 2019 Mar 18;34. Epub 2019 Mar 18.

Department of General and Visceral Surgery, Hospital Bietigheim-Vaihingen, Bietigheim-Vaihingen, Germany.

Background: While minimally invasive surgery is a growing sector in medicine, camera assistance remains a problem. Especially in bariatric surgery, the assistant holding the camera faces certain challenges. Furthermore, unless the surgeon controls the camera movement themselves, they will be challenged by an unstable image. Read More

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Prediction of Treatment Outcome of Chemotherapy Using Perfusion Computed Tomography in Patients with Unresectable Advanced Gastric Cancer.

Korean J Radiol 2019 Apr;20(4):589-598

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Objective: To evaluate whether data acquired from perfusion computed tomography (PCT) parameters can aid in the prediction of treatment outcome after palliative chemotherapy in patients with unresectable advanced gastric cancer (AGC).

Materials And Methods: Twenty-one patients with unresectable AGCs, who underwent both PCT and palliative chemotherapy, were prospectively included. Treatment response was assessed according to Response Evaluation Criteria in Solid Tumors version 1. Read More

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http://dx.doi.org/10.3348/kjr.2018.0306DOI Listing

Advanced gastric cancer presenting as a submucosal tumor of the stomach.

Kaohsiung J Med Sci 2019 Mar 19. Epub 2019 Mar 19.

Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/kjm2.12045
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http://dx.doi.org/10.1002/kjm2.12045DOI Listing
March 2019
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Distribution and localization of porcine calcium sensing receptor (pCaSR) in different tissues of weaned piglets.

J Anim Sci 2019 Mar 19. Epub 2019 Mar 19.

Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada.

Taste receptors including calcium sensing receptor (CaSR) are expressed in various animal tissues, and CaSR plays important roles in nutrient sensing and the physiology, growth and development of animals. However, molecular distribution of porcine CaSR (pCaSR) in different tissues, especially along the longitudinal axis of the digestive tract in weaned piglets are still unknown. In the present study, we investigated the distribution and localization of pCaSR in the different tissues including intestinal segments of weaned piglets. Read More

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http://dx.doi.org/10.1093/jas/skz096DOI Listing

Repair of a giant diaphragmatic hernia using the dual approach.

J Surg Case Rep 2019 Mar 12;2019(3):rjz064. Epub 2019 Mar 12.

Kuwait University, Faculty of Medicine, Kuwait City, Kuwait.

Bochdalek hernias are diaphragmatic defects seen in pediatrics. About 5-25% of the cases are diagnosed in adulthood, and present with symptoms of chest and abdominal problems. This is a case of an 18-year-old male who presented to the emergency department with epigastric pain, vomiting and dyspnea. Read More

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http://dx.doi.org/10.1093/jscr/rjz064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413371PMC

Endoscopic versus laparoscopic management of an eroded mesh in vertical banded gastroplasty: video case series and literature review.

J Surg Case Rep 2019 Mar 12;2019(3):rjz060. Epub 2019 Mar 12.

Royale Hayat Hospital, Jabriya, Kuwait.

Vertical banded gastroplasty (VBG) was one of the most common bariatric surgeries worldwide in the beginning of the 21st century. However, recently we have increasingly encountered its long-term complications. We present two cases of VBG mesh erosion, alongside videos for their management. Read More

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http://dx.doi.org/10.1093/jscr/rjz060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413378PMC

Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence.

Therap Adv Gastroenterol 2019 11;12:1756284819834511. Epub 2019 Mar 11.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong.

Gastric cancer remains one of the leading cancers in the world with a high mortality, particularly in East Asia. infection accounts for the majority of the noncardia gastric cancers by triggering gastric inflammation and subsequent neoplastic progression. Eradication of can reduce, but not totally eliminate, subsequent risk of developing gastric cancer. Read More

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http://dx.doi.org/10.1177/1756284819834511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415482PMC
March 2019
1 Read

Peritoneal Dialysis and Malignancy: An Experience With a Patient Complicated by Gastric Carcinoma.

Clin Med Insights Case Rep 2019 12;12:1179547619835176. Epub 2019 Mar 12.

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.

An 86-year-old man who had been treated with peritoneal dialysis for 14°months due to end-stage kidney disease secondary to hypertensive nephrosclerosis presented with a recent history of malaise, abdominal discomfort, and anorexia. An endoscopic evaluation revealed an elevated, ulcerated, and friable lesion around the lesser curvature of the stomach. The concurrent gastric biopsy specimens revealed moderately differentiated adenocarcinoma, while a cytological examination of the dialysis fluid revealed clusters of malignant cells. Read More

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http://dx.doi.org/10.1177/1179547619835176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415473PMC

Performance of risk stratification systems for gastrointestinal stromal tumors: A multicenter study.

World J Gastroenterol 2019 Mar;25(10):1238-1247

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been proposed.

Aim: To evaluate the application value of four different risk stratification systems for GISTs. Read More

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http://dx.doi.org/10.3748/wjg.v25.i10.1238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421238PMC

PPARD and Interferon gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice.

Gastroenterology 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

Background & Aims: The peroxisome proliferator activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has been associated with gastric and other cancers. Villin-positive epithelial cells are a small population of quiescent gastric progenitor cells. We expressed PPARD from a villin promoter to investigate the role of these cells and PPARD in development of gastric cancer. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.018DOI Listing

Oral tongue cancer in a patient with hereditary nonpolyposis colorectal cancer: A case report and review of the literature.

Oral Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Otolaryngology, Loyola University Medical Center, Maywood, IL, United States.

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by mutations of mismatch repair genes leading to the early development of multiple malignancies. The most common malignancy is colorectal cancer but there is a strong association with malignancies of the ovary, endometrium, small intestine, stomach, skin, brain, and pancreas. We report a case of a 35-year-old female with a history of known HNPCC who presented with adenocarcinoma of the small intestine as well as a synchronous oral tongue squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.008DOI Listing

Postoperative complications and prognosis after radical gastrectomy for gastric cancer: a systematic review and meta-analysis of observational studies.

World J Surg Oncol 2019 Mar 18;17(1):52. Epub 2019 Mar 18.

Xi'an Hospital of Traditional Chinese Medicine, Fengcheng 8th St. 69#, Xi'An City, Shaanxi Province, China.

Background: Many observational studies have reported correlations between postoperative complications and prognosis after radical gastrectomy but the results are controversial. This meta-analysis was performed to investigate whether there is a correlation between postoperative complications and prognosis after radical gastrectomy.

Methods: Literature searches were performed in PubMed, EMBASE, and the Cochrane Library. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1593-9DOI Listing
March 2019
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Optimal Time and Target for Evaluating Energy Delivery after Adjuvant Feeding with Small Bowel Enteral Nutrition in Critically Ill Patients at High Nutrition Risk.

Nutrients 2019 Mar 16;11(3). Epub 2019 Mar 16.

Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Small bowel enteral nutrition (SBEN) may improve nutrient delivery to critically ill patients intolerant of gastric enteral nutrition. However, the optimal time and target for evaluating SBEN efficacy are unknown. This retrospective cohort study investigates these parameters in 55 critically ill patients at high nutrition risk (modified NUTRIC score ≥ 5). Read More

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http://dx.doi.org/10.3390/nu11030645DOI Listing
March 2019
3.148 Impact Factor

Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice.

Food Res Int 2019 May 22;119:751-760. Epub 2018 Oct 22.

Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Federal University of Espirito Santo, Vitoria, ES, Brazil. Electronic address:

The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide. Persea americana Mill. (avocado) seed is a by-product generally discarded as waste, but can be used to treat gastric disorder due to its anti-inflammatory, antioxidant and antimicrobial activities. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.10.057DOI Listing

Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study.

NPJ Sci Food 2018 4;2(1):22. Epub 2018 Dec 4.

Department of Nanobiomedicine/ENT, University Medical Center of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Nanotechnology provides the food industry with new ways to modulate various aspects of food. Hence, engineered nanoparticles (NPs) are increasingly added to food and beverage products as functional ingredients. However, the impact of engineered as well as naturally occurring NPs on both commensal and pathogenic microorganisms within the gastrointestinal tract (GI) is not fully understood. Read More

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http://dx.doi.org/10.1038/s41538-018-0030-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420113PMC
December 2018

[Expression and clinical significance of SSH1 in gastrointestinal stromal tumors].

Zhonghua Yi Xue Za Zhi 2019 Mar;99(10):754-757

Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi 830000, China.

To investigate the correlations between the expression of the slingshot-1(SSH1) and the general clinicopathological factors in gastrointestinal stromal tumor (GIST) patients. Immunohistochemical staining was used to detect the expression of SSH1 protein in 96 gastrointestinal stromal tumors, and the correlations between expression level of SSH1 and general clinicopathological factors were analyzed. Totally, there were 96 cases of GIST patients (49 males and 47 males), with a mean age of (55. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.10.009DOI Listing

Gastrointestinal effects of general anaesthesia in horses undergoing non abdominal surgery: focus on the clinical parameters and ultrasonographic images.

Res Vet Sci 2019 Mar 13;124:123-128. Epub 2019 Mar 13.

Equine Clinic, Department of Companion Animals and Equids, Faculty of Veterinary Medicine, University of Liège, B 41, Avenue de Cureghem, 5D, Quartier Vallée 2, 4000 Liège, Belgium; FARAH, Research Center of the Faculty of Veterinary Medicine of Liège, Belgium.

The ultrasonographic images of the gastrointestinal tract in horses can be influenced by fasting and sedation but the proper effect of general anaesthesia (GA) on them has not been determined yet. This study aimed to evaluate the effects of GA on ultrasonographic images of the gastrointestinal tract in horses and to compare these effects with a clinical evaluation. Twenty horses undergoing non-abdominal surgeries were evaluated by ultrasonography before and 4 times within 24 h after GA. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.03.011DOI Listing

Pharmacokinetics and tissue distribution of Ebracteolatain A, a potential anti-cancer compound, as determined by an optimized ultra-performance liquid chromatography tandem mass spectrometry method.

J Pharm Biomed Anal 2019 Mar 9;169:279-287. Epub 2019 Mar 9.

Department of Pharmacy, Shanghai Baoshan Luodian Hospital, Shanghai, China. Electronic address:

Ebracteolatain A is a phloroglucinol derivative from the root of Euphorbia ebracteolata Hayata, a Traditional Chinese Medicine also known as Langdu. It has been shown to have good inhibitory effects in breast cancer cells. In this study, a simple, rapid, sensitive, and specific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to study the pharmacokinetics (PKs) and tissue distribution of Ebracteolatain A in rats. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.015DOI Listing

Establishment of cell line and in vivo mouse model of canine Langerhans cell histiocytosis.

Vet Comp Oncol 2019 Mar 18. Epub 2019 Mar 18.

Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.

A cell line named FB-LCH01, derived from a dog diagnosed with Langerhans cell histiocytosis, was established and characterized. FB-LCH01 had C-shaped nucleoli, characterized by modal chromosome aberrations. The original tumor cells as well as established FB-LCH01 cells were immunopositive for HLA-DR, Iba-1 and E-cadherin, and immunonegative for CD163 and CD204, suggesting Langerhans cell origin. Read More

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http://dx.doi.org/10.1111/vco.12476DOI Listing

Three case reports of collagenous gastritis in children: Lessons for an endoscopic and histologic approach to mucosal nodularity of the stomach.

Medicine (Baltimore) 2019 Mar;98(11):e14870

Department of Pediatrics, Kangwon National University School of Medicine, Chuncheon, Republic of Korea.

Rationale: Collagenous gastritis (CG) is a rare form of chronic gastritis defined histologically by a thickened subepithelial collageneous band in the lamina propria. However, the clinical features and endoscopic findings of CG have not been clearly established in the pediatric population.

Presenting Concerns: We report the cases of 3 children who presented with intractable anemia and minimal or no gastrointestinal (GI) symptoms and were followed up without definitive diagnosis determination even through diagnostic endoscopic evaluations. Read More

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http://dx.doi.org/10.1097/MD.0000000000014870DOI Listing

How dyspepsia led to the diagnosis of Morbus Crohn.

Acta Clin Belg 2019 Mar 18:1-3. Epub 2019 Mar 18.

b Department of Gastroenterology , University hospital Gasthuisberg , Leuven , Belgium.

Background: It is well known that Crohn's disease can involve the stomach. However, most often this upper gastrointestinal tract involvement is asymptomatic. Typically, there is involvement of the small intestine with the typical associated symptoms of Crohn's disease: abdominal cramps, diarrhoea and weight loss. Read More

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http://dx.doi.org/10.1080/17843286.2019.1590497DOI Listing

Beyond Magnamosis: A Method to Test Sutureless Esophageal Anastomotic Devices in Living Swine by Creating an Esophageal Bypass Loop for Natural Oral Nutrition.

J Laparoendosc Adv Surg Tech A 2019 Mar 18. Epub 2019 Mar 18.

1 Department of Paediatric Surgery, and Universitätsmedizin Mainz der Johannes-Gutenberg-Universität, Mainz, Germany.

Introduction: Thoracoscopic esophageal atresia repair has become increasingly popular, but is still limited to a few expert centers and has some challenges and shortcomings. One of them has a longer operation time compared with conventional thoracotomy. Magnetic compression anastomosis may contribute toward shorter operation times by avoiding the time-consuming anastomotic suturing. Read More

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http://dx.doi.org/10.1089/lap.2018.0778DOI Listing

Unusual Case of Life-Threatening Gastro Intestinal Bleed from a Splenic Artery Pseudoaneurysm: Case Report and Review of Literature.

Case Rep Gastrointest Med 2019 6;2019:8528906. Epub 2019 Feb 6.

Clinical Assistant Professor, Department of Gastroenterology, Aurora St. Luke's Medical Center, 2900 W. Oklahoma Avenue, Milwaukee, WI 53215, USA.

Large upper gastro intestinal (GI) bleeding can be life-threatening. Splenic artery pseudoaenurysm (SAP) is rare but can cause massive upper GI bleeding. We report a case of a 57-year-old woman who had massive upper GI bleeding from SAP eroding into distal duodenum. Read More

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https://www.hindawi.com/journals/crigm/2019/8528906/
Publisher Site
http://dx.doi.org/10.1155/2019/8528906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381554PMC
February 2019
4 Reads

Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.

Oncol Lett 2019 Apr 14;17(4):3890-3898. Epub 2019 Feb 14.

Department of Gastroenterology, University Hospital Heidelberg, D-69120 Heidelberg, Germany.

Recently, a tumor-autonomous cytochrome P450 (CYP)-3A5-mediated resistance to cancer therapy has been demonstrated in pancreatic ductal adenocarcinoma. Expression of CYP3A5, which is involved in the degradation of irinotecan, has also been reported in colorectal cancer (CRC). The aim of the present study was to analyze CYP3A5 expression in the normal colon, colon adenoma, CRC and normal tissues, as well as to examine whether CYP3A5 expression in CRC has an impact on tumor response to irinotecan treatment. Read More

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http://dx.doi.org/10.3892/ol.2019.10043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403523PMC
April 2019
1 Read

4-Dimensional computed tomography analysis of clinical target volume displacement in adjuvant radiation of patients with gastric cancer and its implication on radiotherapy.

Oncol Lett 2019 Apr 13;17(4):3641-3648. Epub 2019 Feb 13.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.

The present study aimed to accurately measure the displacement magnitude of the radiotherapy subsite target due to respiration, and to evaluate its implication on 4-dimensional computed tomography (4D-CT) in adjuvant radiation of gastric cancer. To investigate this, 10 patients with gastric cancer receiving adjuvant radiotherapy were enrolled. 4D-CT scans were performed on all patients and respiratory signals were recorded simultaneously. Read More

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http://dx.doi.org/10.3892/ol.2019.10037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403517PMC

The role and diagnostic potential of gastrokine 1 in gastric cancer.

Cancer Manag Res 2019 1;11:1921-1931. Epub 2019 Mar 1.

Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland,

Introduction: Gene for () was identified as one of the most significant in gastric cancer and indicated as a potential therapeutic target.

Aim: The aim was a review of literature reports concerning the role and diagnostic potential of GKN1 in gastric cancer.

Materials And Methods: PubMED database was searched for sources using the following keywords: gastrokine 1/GKN1/AMP-18 and gastric cancer, , aspirin, nonsteroidal anti-inflammatory drugs. Read More

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http://dx.doi.org/10.2147/CMAR.S194949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402446PMC

Preparation, intestinal segment stability, and mucoadhesion properties of novel thymopentin-loaded chitosan derivatives coated with poly (n-butyl) cyanoacrylate nanoparticles.

Int J Nanomedicine 2019 4;14:1659-1668. Epub 2019 Mar 4.

Department of Pharmacy, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China,

Background: In order to develop a promising carrier for the oral delivery of proteins and peptide drugs, a novel bioadhesive nanocarrier of chitosan (CTS) derivatives coated with poly (n-butyl) cyanoacrylate nanoparticles (PBCA-NPs) was prepared in this study.

Methods: Three different thymopentin (TP5)-loaded nanoparticles were prepared in the present study. TP5-PBCA-NPs were developed by modifying an emulsion polymerization method, and CTS and chitosan-glutathione (CG) derivative-coated PBCA nanoparticles were obtained from the electrostatic interactions between CTS or CG with negatively charged PBCA nanoparticles. Read More

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http://dx.doi.org/10.2147/IJN.S194529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404670PMC

Resection of Mucosal and Submucosal Gastrointestinal Lesions and a Double Endoscope Experience.

JSLS 2019 Jan-Mar;23(1)

Istanbul Training and Research Hospital, Department of General Surgery, Fatih, Istanbul, Turkey.

Aim: The patients who underwent endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for mucosal and submucosal lesions of the esophagus, stomach, and duodenum and the advantages of the double endoscope method we used for traction during ESD were evaluated.

Material And Methods: The patients who underwent ESD and EMR due to upper gastrointestinal lesions were evaluated retrospectively between January 2014 and April 2018 in our endoscopy unit.

Result: The mean age of 10 patients with esophageal lesions was 53 years. Read More

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http://dx.doi.org/10.4293/JSLS.2018.00096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408942PMC

Discovered on gastrointestinal stromal tumor 1, a keystone in the diagnosis of extraintestinal gastrointestinal stromal tumors.

J Cancer Res Ther 2019 Jan-Mar;15(1):138-141

Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.

Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract (GIT) but have a low incidence. Arising from the interstitial cells of Cajal, GISTs occur at different sites in the GIT with stomach being the most common. They can rarely be seen at sites outside the GIT such as omentum, retroperitoneum and are called as extraintestinal GISTs (EGIST). Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_28_17DOI Listing

Various addiction patterns, dietary habits, associated medical problems, and socioeconomic status in gastrointestinal malignancies: A prospective study in rural area of Maharashtra, India.

J Cancer Res Ther 2019 Jan-Mar;15(1):104-107

Department of Radiotherapy and Oncology, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, Maharashtra, India.

Background: Gastrointestinal (GI) malignancies are increasing with advancing age. Various addictions and poor dietary habits are among the major risk factors. Early detection is difficult until patient notices symptoms. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_925_17DOI Listing

Drainage of the right liver under EUS guidance: A bridge technique allowing drainage of the right liver through the left liver into the stomach or jejunum.

Endosc Ultrasound 2019 Mar 12. Epub 2019 Mar 12.

Endoscopy Departement, Endoscopy Unit, Paoli Calmettes Institute, Marseille, France.

Background And Objective: EUS-guided biliary drainage is now comparable to percutaneous drainage. This technique can be used in cases of complex drainage of the hilum, mainly for salvage therapy to drain the left liver. In cases of inaccessible papilla or altered anatomy, EUS-guided biliary drainage for hilar stenosis of the liver could be used as the first approach. Read More

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http://dx.doi.org/10.4103/eus.eus_64_18DOI Listing

Evaluation of a new slim radial echoendoscope: A better option for an aging population.

Endosc Ultrasound 2019 Mar 12. Epub 2019 Mar 12.

Department of Medical and Surgical Sciences, GI Unit, Hospital of Imola, University of Bologna, Bologna, Italy.

Background And Objectives: The radial echoendoscope is still widely used for the investigation of abnormalities in the gastrointestinal wall and for stone detection in the extrahepatic biliary tree. Due to aging patient population, EUS is frequently performed in fragile and elderly individuals. We aimed to compare the maneuverability and image quality of a new thin radial echoendoscope to the current one. Read More

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http://dx.doi.org/10.4103/eus.eus_3_19DOI Listing

Chondrolipoma of the stomach.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Upper Gastrointestinal and Hepatobiliary Unit, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.

Chondrolipoma, a rare variant of a lipoma, is a benign mesenchymal neoplasm characterised by mature adipocytes with neoplastic hyaline cartilage formation. We describe the first case of a gastric chondrolipoma. The tumour was completely excised via laparoscopic gastric wedge resection with uneventful postoperative recovery. Read More

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http://dx.doi.org/10.1136/bcr-2018-228757DOI Listing

Huge trichobezoar presenting as abdominal mass and weight loss: Case report.

Int J Surg Case Rep 2019 Mar 7;57:33-35. Epub 2019 Mar 7.

University of Duhok, College of Medicine, Department of Surgery, Iraq.

Introduction: Trichobezoar is a condition in which hair is accumulated in the stomach forming a ball like mass. Human hair is resistant to digestion and peristalsis therefore over time it accumulates in the gastric folds. Trichophagia and trichotillomania is a psychiatric disorder in which the affected person has the tendency to pull her or his own hair and ingest it. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.033DOI Listing

The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma.

Eur J Cancer 2019 Mar 14;112:1-8. Epub 2019 Mar 14.

Tumor- und Brustzentrum ZeTuP, St. Gallen, Switzerland.

Multimodal primary treatment of localised adenocarcinoma of the stomach, the oesophagus and the oesophagogastric junction (AEG) was reviewed by a multidisciplinary expert panel in a moderated consensus session. Here, we report the key points of the discussion and the resulting recommendations. The exact definition of the tumour location and extent by white light endoscopy in conjunction with computed tomography scans is the backbone for any treatment decision. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.106DOI Listing

A Novel Gastric Spheroid Co-Culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium.

Cell Mol Gastroenterol Hepatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Microbiology and Immunology, Montana State University, Bozeman, MT, USA. Electronic address:

Background & Aims: Gastric dendritic cells (DCs) control the adaptive response to infection with Helicobacter pylori, a major risk factor for peptic ulcer disease and gastric cancer. We hypothesize that DC interactions with the gastric epithelium position gastric DCs for uptake of luminal H. pylori and promote DC responses to epithelial-derived mediators. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.02.010DOI Listing

Nanoparticles in foods? A multiscale physiopathological investigation of iron oxide nanoparticle effects on rats after an acute oral exposure: Trace element biodistribution and cognitive capacities.

Food Chem Toxicol 2019 Mar 13. Epub 2019 Mar 13.

Grenoble Alpes University, PROMETHEE Proteomic Platform, BEeSy, Grenoble, France; LBFA Inserm U1055, BEeSy, Grenoble, France; Institut de Biologie et Pathologie, CHU de Grenoble Alpes, France.

Iron Oxide Nanoparticles (IONPs) are used in several fields of application, mainly in the biomedical field for their magnetic properties and in food additive known as "E172" for their colour. In the present investigation, we focused on IONP effects on Wistar rat following acute oral exposure. We performed a multiscale physiopathological investigation in order to elucidate potential toxic effects linked to IONP ingestion, especially on cognitive capacities, trace element distribution, blood constituents, organ functions, organ structure and iron deposit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193011
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http://dx.doi.org/10.1016/j.fct.2019.03.006DOI Listing
March 2019
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Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.

Mol Cell Biochem 2019 Mar 15. Epub 2019 Mar 15.

Departamento de Biologia Celular, Cinvestav-IPN, Av. IPN # 2508, 07360, Mexico, DF, Mexico.

Linoleic acid (LA) is an essential and omega-6 polyunsaturated fatty acid that mediates a variety of biological processes, including migration and invasion in breast cancer cells. Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Increases of expression and activity of PLD are reported in several human cancers, including gastric, colorectal, renal, stomach, lung and breast. Read More

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http://link.springer.com/10.1007/s11010-019-03517-8
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http://dx.doi.org/10.1007/s11010-019-03517-8DOI Listing
March 2019
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Malignancies associated with GIST: a retrospective study with molecular analysis of KIT and PDGFRA.

Langenbecks Arch Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Pathology, FAU Erlangen-Nürnberg, Erlangen, Germany.

Purpose: Gastrointestinal stromal tumors (GISTs) are the most common soft tissue tumors of the GI tract. Studies have been published reporting additional neoplasms in GIST patients. This study aimed to evaluate possible associations of mutation type, morphology, and clinical aspects of GISTs. Read More

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http://dx.doi.org/10.1007/s00423-019-01773-2DOI Listing
March 2019
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Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands.

J Med Genet 2019 Mar 15. Epub 2019 Mar 15.

Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Background: Spasmolytic polypeptide-expressing metaplasia (SPEM) is present in more than 90% of resected gastric cancer tissues. However, although widely regarded as a pre-cancerous tissue, its genetic characteristics have not been well studied.

Methods: Immunohistochemistry using Trefoil factor 2 (TFF2) antibodies was used to identify TFF2-positive SPEM cells within SPEM glands in the stomach of -infected mice and human clinical samples. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105752DOI Listing
March 2019
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Protective effect of [Pyr1]-apelin-13 on oxidative stress-induced apoptosis in hair cell -like cells derived from bone marrow mesenchymal stem cells.

Eur J Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Oxidative stress plays an important role in auditory dysfunction. Exogenous cell therapy has brought new hopes for repairing mammalian inner ear hair cells. However, poor cell viability of transplanted cells under oxidative stress conditions has limited their therapeutic potential. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193016
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http://dx.doi.org/10.1016/j.ejphar.2019.03.012DOI Listing
March 2019
3 Reads

Cancer burden in the Caribbean: an overview of the Martinique Cancer Registry profile.

BMC Cancer 2019 Mar 15;19(1):239. Epub 2019 Mar 15.

CHU Martinique, Pôle de Cancérologie Hématologie, Urologie Pathologie, CHU Martinique, Fort-de-France, Martinique.

Background: Cancer indicators are essential information for cancer surveillance and cancer research strategy development. The Martinique Cancer Registry (MCR) is a population-based cancer Registry (PBCR) that has been recording cancer data since its creation in 1981. This article provides cancer incidence and mortality data for all cancers and for major tumor sites. Read More

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http://dx.doi.org/10.1186/s12885-019-5434-6DOI Listing