252 results match your criteria Stewart-Treves Syndrome
Cutis 2018 Oct;102(4):E8-E11
Wright State University Boonshoft School of Medicine, Dayton, and Jobst Vascular Institute/ProMedica Health System Toledo Hospital, Ohio, USA.
Angiosarcoma is a vascular malignancy that can affect various anatomic sites. Although rare, cutaneous angiosarcoma is the most common clinical manifestation, accounting for approximately 50% to 60% of cases. Cutaneous angiosarcoma typically is known to occur in 3 settings: (1) idiopathic, (2) following radiation treatment, and (3) in the setting of chronic lymphedema following mastectomy (known as Stewart-Treves syndrome). Read More
SAGE Open Med Case Rep 2018 30;6:2050313X18796343. Epub 2018 Oct 30.
Division of Dermatology, Department of Medicine, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
Chronic lymphedema is rarely complicated by an angiosarcoma. Angiosarcoma superimposed on chronic lymphedema (Stewart-Treves syndrome) is usually seen post breast cancer surgery accompanied by lymph node resection of the axilla. This is a case report of a 59-year-old male patient with elephantiasis that developed an angiosarcoma of the lower leg. Read More
Open Access Maced J Med Sci 2018 Sep 20;6(9):1688-1693. Epub 2018 Sep 20.
Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.
Background: Kaposi's sarcoma was first described in 1872 by Moritz Kaposi. To date, it is considered a malignant disease is originating from the endothelial cells of the lymphatic vessels believed to be infected with HHV-8. The current classification defines four major epidemiological forms of Kaposi's sarcoma: classical, endemic, AIDS-associated, and iatrogenic. Read More
J Belg Soc Radiol 2018 Oct 1;102(1):60. Epub 2018 Oct 1.
AZ Delta Roeselare, BE.
Actas Dermosifiliogr 2018 Sep 24. Epub 2018 Sep 24.
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. Electronic address:
Kaposi sarcoma is a vascular sarcoma with 4 clinical variants: classic Kaposi sarcoma, which mainly affect the extremities of elderly patients and follows a chronic, generally indolent course; African Kaposi sarcoma; immunosuppression-associated Kaposi sarcoma; and AIDS-associated Kaposi sarcoma. Type8 human herpesvirus is the etiologic agent in all 4variants. Cutaneous angiosarcoma is a cutaneous neoplasm with a very poor prognosis. Read More
Pediatr Dermatol 2018 Nov 14;35(6):e382-e388. Epub 2018 Sep 14.
Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium.
We herein report the case of a 3-year-old girl with atypical congenital right upper limb lymphedema who developed an angiosarcoma. Only a few cases have been reported following congenital form of lymphedema and only 4 in such a young child. We also summarize all cases of angiosarcoma associated with congenital lymphedema reported in the literature. Read More
Indian Dermatol Online J 2018 May-Jun;9(3):177-181
Department of Dermatology, Topiwala National Medical College and B.Y.L. Nair Hospital, Mumbai, Maharashtra, India.
Angiosarcoma (AS) is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels. These are aggressive tumors and tend to recur locally, spread widely with high rate of lymph node and systemic metastases. They are more frequent in skin and soft tissue, head and neck being the most common sites. Read More
Open Access Maced J Med Sci 2018 Apr 14;6(4):663-665. Epub 2018 Apr 14.
Helios Klinikum GMBH - Dermatology, Venereology and Allergology, Hildesheim, Germany.
Background: The Stewart-Treves syndrome with localisation in the region of the lower extremities is not something unusual as clinical pathology, but the clinical diagnostics is rather difficult, and it can be further complicated maximally because of: the similar locoregional findings in patients with other cutaneous malignancies.
Case Report: Presented is a rare form of an epithelioid variant of the Stewart Treves syndrome in a woman, aged 81, localised in the region of the lower leg and significantly advanced only for 2 months. The diagnosis was confirmed histologically and immunohistochemically. Read More
Ann Dermatol Venereol 2018 Apr 9;145(4):266-269. Epub 2018 Mar 9.
Dermatologie, hôpital Saint-Vincent, Lille, France; Université catholique de Lille, Lille, France.
Background: Chronic lymphoedema is classically complicated by recurring episodes of cellulitis. Degeneration to the angiosarcoma form (Stewart-Treves syndrome) is much less common. It occurs mainly in the upper limbs following surgery or radiotherapy for mammary neoplasia. Read More
Oncol Lett 2018 Jan 8;15(1):1113-1118. Epub 2017 Nov 8.
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
The aim of the present study was to evaluate the magnetic resonance imaging (MRI) data of patients with Stewart-Treves Syndrome (STS), and to compare them with the corresponding pathological data. A total of 4,289 cases of secondary upper limb lymphedema (LE) from a single center, including 5 female cases of STS who underwent modified-radical post mastectomy, were included in the study. All cases were diagnosed pathologically, and by conventional and contrast-enhanced (ce)MRI scans. Read More
JAAD Case Rep 2017 Nov 6;3(6):515-518. Epub 2017 Nov 6.
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas.
Clin Nucl Med 2017 Dec;42(12):e519-e522
From the *Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen; †Department of Orthopedic Surgery, Odense University Hospital, University of Southern Denmark, Odense; ‡Musculoskeletal Tumor Section, Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Copenhagen; and §Department of Nuclear Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Angiosarcomas are highly malignant and rare tumors of vascular or lymphatic endothelial cell origin with a poor prognosis. Lymphangiosarcoma associated with chronic lymphedema is known as Stewart-Treves syndrome. Stewart-Treves syndrome is primarily described in patients with lymphedema of an upper extremity occurring after breast cancer surgery including radical axillary lymph node dissection and subsequent radiotherapy. Read More
An Bras Dermatol 2017 Mar-Apr;92(2):235-238
Universidade Federal do Espírito Santo (Ufes) - Vitória (ES), Brazil.
Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast. Read More
Pan Afr Med J 2016 17;25:89. Epub 2016 Oct 17.
Service de Dermatologie Vénéréologie, CHU Ibn Rochd, Université Hassan II, Casablanca, Maroc.
Case Rep Surg 2017 9;2017:4056459. Epub 2017 Feb 9.
Department of General Surgery "A", Dr. Tidjani Damerdji University Hospital of Tlemcen, Tlemcen, Algeria; Experimental Surgery Laboratory N°38, Medical School of Tlemcen, University of Abou Bekr Belkaid, Tlemcen, Algeria.
Steward-Treves syndrome is a cutaneous angiosarcoma that usually appears after long evolution of a lymphoedema after mastectomy for mammary neoplasia associated with an axillary dissection. This is a rare disease develop most of the time in upper arm and often confounded with cutaneous metastasis. Only the biopsy and immunohistochemical study confirm the diagnosis. Read More
Pan Afr Med J 2016 7;24:196. Epub 2016 Jul 7.
Service de Dermatologie-Vénérologie, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.
Australas J Dermatol 2016 Nov;57(4):e146-e147
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Pathology 2016 Dec 22;48(7):697-704. Epub 2016 Oct 22.
Department of Pathology, University of Michigan Health System, Ann Arbor, MI, United States. Electronic address:
Angiosarcoma (AS) is an uncommon vascular malignancy with an aggressive clinical course. Radiation-associated angiosarcoma (RAAS) and Stewart-Treves syndrome are associated with MYC gene amplification and protein overexpression, while other radiation-associated vascular lesions including atypical vascular lesions (AVL) are not associated with MYC overexpression. In contrast, de novo AS represent a group of molecularly heterogeneous tumours, for which MYC expression has not been extensively examined. Read More
JAAD Case Rep 2016 Sep 11;2(5):397-399. Epub 2016 Oct 11.
Department of Dermatology, St Joseph Mercy Hospital, Ann Arbor, Michigan.
Medicine (Baltimore) 2016 Aug;95(33):e4316
aDivision of Gastroenterology and Hematology/Oncology, Department of Medicine bDepartment of Dermatology, Asahikawa Medical University, Hokkaido cGastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa dCenter for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
Background: Pancreatic involvement of angiosarcoma is extremely rare.
Methods: We herein report a rare case of angiosarcoma associated with chronic lymphedema (Stewart-Treves syndrome) with pancreatic metastasis that was diagnosed using endoscopic ultrasound (EUS)/fine needle aspiration (FNA).
Results: A 43-year-old woman with a history of radical hysterectomy with bilateral inguinal lymphadenectomy and chemoradiotherapy for cervical cancer 15 years prior noticed the presence of erythematous indurative plaques on her right femoral region, where chronic lymphedema had developed. Read More
Case Rep Oncol 2016 Jan-Apr;9(1):205-11. Epub 2016 Apr 1.
Department of Critical Care Medicine, University of Miami, Miller School of Medicine, Miami, Fla., USA.
The Stewart-Treves syndrome is a rare and deadly entity, which is defined as angiosarcoma arising in the setting of chronic lymphedema. It typically presents in women who develop lymphedema in the upper extremity secondary to axillary lymph node dissection for breast cancer surgery. It is extremely uncommon in the lower extremities as a result of idiopathic chronic lymphedema. Read More
J Clin Diagn Res 2016 Feb 1;10(2):WD01-2. Epub 2016 Feb 1.
Assistant Professor, Department of Pathology, Karabük Education and Research Hospital , Turkey .
Stewart Treves Syndrome is an angiosarcoma generally seen long time after radical mastectomy in breast carcinoma patients in chronic lymphoedema area. It's an angiosarcoma developed on a long standing lymphoedema, following a radical mastectomy. An 86-year-old woman was referred to our Dermatology outpatient clinic which developed a giant erythematous, oedematous, purplish lobulated plaque on her right forearm anteromedially with a few satellite erythematous papulonodules on her arm. Read More
Indian J Surg 2015 Dec 25;77(Suppl 3):1421-2. Epub 2015 Jan 25.
Department of General Surgery, Turgut Özal University, Ankara, Turkey.
Lymphangiectasia is characterized by vesicular dilation of lymphatic vessels and is generally a complication of radiotherapy or surgery of various malignant tumors such as breast and cervical cancers. Although it is not a precancerous disease, correct diagnosis is important to rule out Stewart-Treves syndrome which is defined as lymphangiosarcoma that develops in long-standing chronic postmastectomy lymphedema. Observation alone or many therapeutic options including cryosurgery, electrocauterization, sclerotherapy, and excision have been widely used in the management. Read More
J Vasc Interv Radiol 2016 Mar;27(3):444-6
Interventional Radiology Unit, Veneto Region Oncology Research Institute IOV-IRCCS, Via Gattamelata, 64, Padova 35128, Italy.
Int J Clin Exp Pathol 2015 1;8(9):11108-15. Epub 2015 Sep 1.
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730, China.
Aims: To study the clinicopathologic features of Stewart-Treves syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options.
Methods And Results: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Read More
Lymphat Res Biol 2016 Mar 19;14(1):35-9. Epub 2015 Nov 19.
1 Division of Plastic Surgery, Department of Trauma Surgery, Plastic and Reconstructive Surgery, University Medical Centre , Göttingen, Germany .
Background: Stewart-Treves syndrome is a rare complication of breast cancer treatment, representing a lymphangiosarcoma commonly associated with lymphedema and severely impacting patient's outcome. The tumor typically develops in the atrophic, pachydermatous, hyperkeratotic skin of limbs affected by long-standing lymphedema. Clinical data associated with Stewart-Treves syndrome and lymphedema management have rarely been published. Read More
Rev Med Interne 2016 May 10;37(5):377-8. Epub 2015 Oct 10.
Service de médecine interne, hôpitaux de Rouen, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):232-4
Universidade Federal do Pará, Belém, PA, BR.
Stewart-Treves syndrome is a rare cutaneous angiosarcoma that develops in long-standing chronic lymphedema. Though most commonly this angiosarcoma is a result of post mastectomy lymphoedema, it also develops in Milroy disease, idiopathic, congenital, traumatic and filarial lymphoedema. Despite the rarity of this syndrome and its poor prognosis, early diagnosis associated with radical surgery can provide improved survival. Read More
An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):229-31
Pontifícia Universidade Católica de Campinas, Campinas, SP, BR.
Stewart-Treves Syndrome is characterized by the presence of lymphangiosarcoma on limb extremities. Rare, it occurs in 0.5% of patients who have undergone radical mastectomy with axillary node dissection. Read More
J Cutan Pathol 2015 Nov 21;42(11):889-93. Epub 2015 Sep 21.
Department of Dermatology and Pathology, Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
Classical Kaposi sarcoma (KS) usually appears on lower extremities accompanied or preceded by local lymphedema. However, the development in areas of chronic lymphedema of the arms following mastectomy, mimicking a Stewart-Treves syndrome, has rarely been described. We report an 81-year-old woman who developed multiple, erythematous to purple tumors, located on areas of post mastectomy lymphedema. Read More
Breast Cancer 2016 Sep 5;23(5):718-23. Epub 2015 Aug 5.
Breast Surgery Division, National Cancer Center Hospital, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo, 104-0045, Japan.
Background: Breast angiosarcomas are rare neoplasm. Due to its rarity, our therapeutic strategy is extremely limited. Therefore, we investigated the clinicopathologic features and examined the treatment for angiosarcoma compared with some literatures. Read More
J Dtsch Dermatol Ges 2015 Aug;13(8):818-20
Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Saitama, Japan.
Breast J 2015 Sep-Oct;21(5):552-4. Epub 2015 Jul 23.
Department of Dermatology, "Maggiore della Carità" Hospital, University of Eastern Piedmont "A. Avogadro", Novara, Italy.
J Wound Care 2015 Jun;24(6 Suppl):S5-7
Liverpool Sarcoma Unit, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Merseyside, UK.
Patients with skin complaints secondary to oedema are commonly encountered and can be a diagnostic challenge. Here, we present the case of a 78-year-old lady with Stewart-Treves syndrome, a rare cutaneous angiosarcoma. The histology showed angiocutaneous sarcoma with poorly defined margins. Read More
J Dermatol 2015 Apr 21;42(4):426-7. Epub 2015 Feb 21.
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Lymphat Res Biol 2015 Sep 6;13(3):228-9. Epub 2015 Feb 6.
Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School , Boston, Massachusetts.
Pan Afr Med J 2014 1;19. Epub 2014 Sep 1.
Department of Surgical Oncology, National Institute of Oncology, Rabat, Morocco.
The Stewart-Treves syndrome was first described in 1948, it's an angiosarcoma developed on a longstanding lymphadenomatous limb, more often after radical mastectomy. Diagnosis is made on skin biopsy and the prognosis is poor when radical surgery can't be performed. We report the case on a Stewart-Treves syndrome in a sixty-six years old woman who underwent radical mastectomy for breast carcinoma ten years earlier. Read More
J Breast Health 2015 Apr 1;11(2):92-94. Epub 2015 Apr 1.
Department of Radiation Oncology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Stewart-Treves syndrome is an angiosarcoma that occurs because of chronic lymphedema, which in most cases is a complication after mastectomy with axillary node dissection and postoperative radiation. Prognosis for this rare tumor is poor. The best therapy is early and radical excision. Read More
Diagn Pathol 2014 Oct 29;9:197. Epub 2014 Oct 29.
Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Benign lymphangioendothelioma (BL) represents a very rare lymphatic vascular proliferation. Our aim is to be aware that owing to its characteristic features, pathologists can easily misinterpret it as cutaneous low-grade angiosarcoma when examining only small specimens. In the present case, multiple small and yellowish to reddish soft nodules were noticed in the edematous left arm of a 54-year-old Japanese female 4 years after the radical mastectomy with axillary lymph nodes dissection and following radiotherapy to the chest for the left breast carcinoma. Read More
Clin Dermatol 2014 Sep-Oct;32(5):616-20
Department of Dermatology, Rutgers University - New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey, 07103. Electronic address:
Chronic lymphedema has a permissive effect with certain types of malignancies, particularly angiosarcomas, in what is known as Stewart-Treves syndrome. The presumed mechanism of this effect is an immunocompromised district of the affected area. Most other cutaneous malignancies have also been described in lymphedematous areas, including basal cell carcinoma, squamous cell carcinoma, melanoma, Kaposi sarcoma, Merkel cell carcinoma, and several cutaneous lymphomas. Read More
Clin Dermatol 2014 Sep-Oct;32(5):569-76
Dermatology Unit, Kaplan Medical Center, Rehovot, Israel. Affiliated to The School of Medicine, Hebrew University and Hadassah, Jerusalem.
Besides the systemic immune deficiency, a sectorial default in immune control may occur in immunocompetent subjects. This regional immune defect can appear and remain confined to differently damaged skin areas, lately labeled immunocompromised districts (ICDs). An ICD is a skin area more vulnerable than the rest of the body for genetic or acquired reasons. Read More
Ned Tijdschr Geneeskd 2014 ;158:A7810
Antoni van Leeuwenhoek, Amsterdam.
A woman with postmastectomy lymphoedema presented with purple-red nodules on the right upper arm. Histopathology of a skin biopsy showed a cutaneous angiosarcoma. Angiosarcoma arising in an oedematous arm is called the Stewart-Treves syndrome and is a rare and late complication of breast cancer treatment. Read More
Indian J Med Res 2014 Jan;139(1):179
Department of General Surgery of Wolski Hospital, Warsaw, Poland.
Clin Nucl Med 2014 Nov;39(11):975-6
From the *Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; †Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; and ‡School of Medicine, China Medical University, Taichung, Taiwan.
This 17-year-old woman had chronic congenital lymphedema in the left lower extremity since childhood. She underwent surgeries to remove excessive lymphedematous tissues more than 15 times previously. Histopathology of the specimen from the recent surgery revealed angiosarcoma; therefore, FDG-PET/CT scan was arranged to determine the extent of tumor spread, and distant metastases were discovered. Read More
Pan Afr Med J 2014 21;19:311. Epub 2014 Nov 21.
Service de Radiothérapie-Oncologie, Centre hospitalier Ibn Rochd, Casablanca 1, quartier des hôpitaux 20360, Casablanca, Maroc.
Case Rep Pathol 2013 3;2013:931973. Epub 2013 Sep 3.
Department of Pathology, Tours University Hospital, 37044 Tours, France.
Angiosarcomas are rare aggressive neoplasms that can occur secondary to chronic lymphedema (Stewart-Treves syndrome). Although secondary angiosarcomas are commonly described after-mastectomy and/or after-radiotherapy, few cases have been reported in association with chronic lymphedema of congenital origin. We report the clinical, pathological, and cytogenetic findings in a case of cutaneous epithelioid clear cells angiosarcoma that occurred in a 21-year-old woman with hemibody congenital lymphedema. Read More
Ann R Coll Surg Engl 2013 Jul;95(5):e80-2
Memorial Sloan-Kettering Cancer Center, 1,275 York Avenue, Suite A342, New York, NY 10065, USA.
We present a case of chronic lymphoedema that progressed to Stewart-Treves syndrome in a 63-year-old woman with a previous modified radical mastectomy, associated lymph node dissection, chemotherapy and radiotherapy. While producing stabilisation of most cutaneous lesions initially, chemotherapeutic treatment of the angiosarcoma did not prevent subsequent metastasis and patient death. We urge vigilance and regular follow-up appointments for patients following a mastectomy with chronic lymphoedema to facilitate prevention or early treatment of this devastating syndrome. Read More
Ann Surg Oncol 2013 Oct 9;20(11):3391-7. Epub 2013 Jul 9.
Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Background: Cutaneous angiosarcoma (CAS) is a rare, aggressive vascular sarcoma with a poor prognosis, historically associated with 5-year overall survival (OS) rates between 10 and 30 %.
Methods: This is a single-institution retrospective review of patients treated for CAS from 1999-2011. Demographics, primary tumor characteristics, treatment, and outcomes were analyzed. Read More
J Pak Med Assoc 2013 May;63(5):646-9
Department of Pathology and Microbiology, Faculty of Health Sciences, Medical College, Aga Khan University Hospital, Karachi, Pakistan.
Angiosarcomas account for less than 0.05% of the malignant neoplasms of the breast. We present here 7 cases of malignant vascular neoplasms of the breast, including 2 cases of postmastectomy Stewart-Treves syndrome. Read More