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    218 results match your criteria Stewart-Treves Syndrome

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    Stewart-Treves Syndrome Involving Chronic Lymphedema after Mastectomy of Breast Cancer.
    Case Rep Surg 2017 9;2017:4056459. Epub 2017 Feb 9.
    Department of General Surgery "A", Dr. Tidjani Damerdji University Hospital of Tlemcen, Tlemcen, Algeria; Experimental Surgery Laboratory N°38, Medical School of Tlemcen, University of Abou Bekr Belkaid, Tlemcen, Algeria.
    Steward-Treves syndrome is a cutaneous angiosarcoma that usually appears after long evolution of a lymphoedema after mastectomy for mammary neoplasia associated with an axillary dissection. This is a rare disease develop most of the time in upper arm and often confounded with cutaneous metastasis. Only the biopsy and immunohistochemical study confirm the diagnosis. Read More

    MYC immunohistochemistry in angiosarcoma and atypical vascular lesions: practical considerations based on a single institutional experience.
    Pathology 2016 Dec 22;48(7):697-704. Epub 2016 Oct 22.
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI, United States. Electronic address:
    Angiosarcoma (AS) is an uncommon vascular malignancy with an aggressive clinical course. Radiation-associated angiosarcoma (RAAS) and Stewart-Treves syndrome are associated with MYC gene amplification and protein overexpression, while other radiation-associated vascular lesions including atypical vascular lesions (AVL) are not associated with MYC overexpression. In contrast, de novo AS represent a group of molecularly heterogeneous tumours, for which MYC expression has not been extensively examined. Read More

    Pancreatic metastasis of angiosarcoma (Stewart-Treves syndrome) diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report.
    Medicine (Baltimore) 2016 Aug;95(33):e4316
    aDivision of Gastroenterology and Hematology/Oncology, Department of Medicine bDepartment of Dermatology, Asahikawa Medical University, Hokkaido cGastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa dCenter for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
    Background: Pancreatic involvement of angiosarcoma is extremely rare.

    Methods: We herein report a rare case of angiosarcoma associated with chronic lymphedema (Stewart-Treves syndrome) with pancreatic metastasis that was diagnosed using endoscopic ultrasound (EUS)/fine needle aspiration (FNA).

    Results: A 43-year-old woman with a history of radical hysterectomy with bilateral inguinal lymphadenectomy and chemoradiotherapy for cervical cancer 15 years prior noticed the presence of erythematous indurative plaques on her right femoral region, where chronic lymphedema had developed. Read More

    Stewart-Treves Syndrome: A Case Report and Review of the Literature.
    Case Rep Oncol 2016 Jan-Apr;9(1):205-11. Epub 2016 Apr 1.
    Department of Critical Care Medicine, University of Miami, Miller School of Medicine, Miami, Fla., USA.
    The Stewart-Treves syndrome is a rare and deadly entity, which is defined as angiosarcoma arising in the setting of chronic lymphedema. It typically presents in women who develop lymphedema in the upper extremity secondary to axillary lymph node dissection for breast cancer surgery. It is extremely uncommon in the lower extremities as a result of idiopathic chronic lymphedema. Read More

    Stewart Treves Syndrome in a Woman with Mastectomy.
    J Clin Diagn Res 2016 Feb 1;10(2):WD01-2. Epub 2016 Feb 1.
    Assistant Professor, Department of Pathology, Karabük Education and Research Hospital , Turkey .
    Stewart Treves Syndrome is an angiosarcoma generally seen long time after radical mastectomy in breast carcinoma patients in chronic lymphoedema area. It's an angiosarcoma developed on a long standing lymphoedema, following a radical mastectomy. An 86-year-old woman was referred to our Dermatology outpatient clinic which developed a giant erythematous, oedematous, purplish lobulated plaque on her right forearm anteromedially with a few satellite erythematous papulonodules on her arm. Read More

    Acquired Lymphangiectasia of the Breast After Breast Conserving Surgery.
    Indian J Surg 2015 Dec 25;77(Suppl 3):1421-2. Epub 2015 Jan 25.
    Department of General Surgery, Turgut Özal University, Ankara, Turkey.
    Lymphangiectasia is characterized by vesicular dilation of lymphatic vessels and is generally a complication of radiotherapy or surgery of various malignant tumors such as breast and cervical cancers. Although it is not a precancerous disease, correct diagnosis is important to rule out Stewart-Treves syndrome which is defined as lymphangiosarcoma that develops in long-standing chronic postmastectomy lymphedema. Observation alone or many therapeutic options including cryosurgery, electrocauterization, sclerotherapy, and excision have been widely used in the management. Read More

    Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature.
    Int J Clin Exp Pathol 2015 1;8(9):11108-15. Epub 2015 Sep 1.
    Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730, China.
    Aims: To study the clinicopathologic features of Stewart-Treves syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options.

    Methods And Results: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Read More

    Lymphangiosarcoma: Is Stewart-Treves Syndrome a Preventable Condition?
    Lymphat Res Biol 2016 Mar 19;14(1):35-9. Epub 2015 Nov 19.
    1 Division of Plastic Surgery, Department of Trauma Surgery, Plastic and Reconstructive Surgery, University Medical Centre , Göttingen, Germany .
    Background: Stewart-Treves syndrome is a rare complication of breast cancer treatment, representing a lymphangiosarcoma commonly associated with lymphedema and severely impacting patient's outcome. The tumor typically develops in the atrophic, pachydermatous, hyperkeratotic skin of limbs affected by long-standing lymphedema. Clinical data associated with Stewart-Treves syndrome and lymphedema management have rarely been published. Read More

    Stewart-Treves Syndrome of the Lower Extremity.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):232-4
    Universidade Federal do Pará, Belém, PA, BR.
    Stewart-Treves syndrome is a rare cutaneous angiosarcoma that develops in long-standing chronic lymphedema. Though most commonly this angiosarcoma is a result of post mastectomy lymphoedema, it also develops in Milroy disease, idiopathic, congenital, traumatic and filarial lymphoedema. Despite the rarity of this syndrome and its poor prognosis, early diagnosis associated with radical surgery can provide improved survival. Read More

    Stewart Treves Syndrome.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):229-31
    Pontifícia Universidade Católica de Campinas, Campinas, SP, BR.
    Stewart-Treves Syndrome is characterized by the presence of lymphangiosarcoma on limb extremities. Rare, it occurs in 0.5% of patients who have undergone radical mastectomy with axillary node dissection. Read More

    Kaposi sarcoma following postmastectomy lymphedema.
    J Cutan Pathol 2015 Nov 21;42(11):889-93. Epub 2015 Sep 21.
    Department of Dermatology and Pathology, Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
    Classical Kaposi sarcoma (KS) usually appears on lower extremities accompanied or preceded by local lymphedema. However, the development in areas of chronic lymphedema of the arms following mastectomy, mimicking a Stewart-Treves syndrome, has rarely been described. We report an 81-year-old woman who developed multiple, erythematous to purple tumors, located on areas of post mastectomy lymphedema. Read More

    Clinicopathological features of breast angiosarcoma.
    Breast Cancer 2016 Sep 5;23(5):718-23. Epub 2015 Aug 5.
    Breast Surgery Division, National Cancer Center Hospital, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo, 104-0045, Japan.
    Background: Breast angiosarcomas are rare neoplasm. Due to its rarity, our therapeutic strategy is extremely limited. Therefore, we investigated the clinicopathologic features and examined the treatment for angiosarcoma compared with some literatures. Read More

    Stewart-Treves syndrome following idiopathic leg lymphoedema: remember sarcoma.
    J Wound Care 2015 Jun;24(6 Suppl):S5-7
    Liverpool Sarcoma Unit, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Merseyside, UK.
    Patients with skin complaints secondary to oedema are commonly encountered and can be a diagnostic challenge. Here, we present the case of a 78-year-old lady with Stewart-Treves syndrome, a rare cutaneous angiosarcoma. The histology showed angiocutaneous sarcoma with poorly defined margins. Read More

    Stewart-Treves syndrome: a case report.
    Pan Afr Med J 2014 1;19. Epub 2014 Sep 1.
    Department of Surgical Oncology, National Institute of Oncology, Rabat, Morocco.
    The Stewart-Treves syndrome was first described in 1948, it's an angiosarcoma developed on a longstanding lymphadenomatous limb, more often after radical mastectomy. Diagnosis is made on skin biopsy and the prognosis is poor when radical surgery can't be performed. We report the case on a Stewart-Treves syndrome in a sixty-six years old woman who underwent radical mastectomy for breast carcinoma ten years earlier. Read More

    Stewart-Treves Syndrome after Bilateral Mastectomy and Radiotherapy for Breast Carcinoma: Case Report.
    J Breast Health (2013) 2015 Apr 1;11(2):92-94. Epub 2015 Apr 1.
    Department of Radiation Oncology, Kayseri Training and Research Hospital, Kayseri, Turkey.
    Stewart-Treves syndrome is an angiosarcoma that occurs because of chronic lymphedema, which in most cases is a complication after mastectomy with axillary node dissection and postoperative radiation. Prognosis for this rare tumor is poor. The best therapy is early and radical excision. Read More

    Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome.
    Diagn Pathol 2014 Oct 29;9:197. Epub 2014 Oct 29.
    Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
    Benign lymphangioendothelioma (BL) represents a very rare lymphatic vascular proliferation. Our aim is to be aware that owing to its characteristic features, pathologists can easily misinterpret it as cutaneous low-grade angiosarcoma when examining only small specimens. In the present case, multiple small and yellowish to reddish soft nodules were noticed in the edematous left arm of a 54-year-old Japanese female 4 years after the radical mastectomy with axillary lymph nodes dissection and following radiotherapy to the chest for the left breast carcinoma. Read More

    Lymphedema-related angiogenic tumors and other malignancies.
    Clin Dermatol 2014 Sep-Oct;32(5):616-20
    Department of Dermatology, Rutgers University - New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey, 07103. Electronic address:
    Chronic lymphedema has a permissive effect with certain types of malignancies, particularly angiosarcomas, in what is known as Stewart-Treves syndrome. The presumed mechanism of this effect is an immunocompromised district of the affected area. Most other cutaneous malignancies have also been described in lymphedematous areas, including basal cell carcinoma, squamous cell carcinoma, melanoma, Kaposi sarcoma, Merkel cell carcinoma, and several cutaneous lymphomas. Read More

    The immunocompromised district in dermatology: A unifying pathogenic view of the regional immune dysregulation.
    Clin Dermatol 2014 Sep-Oct;32(5):569-76
    Dermatology Unit, Kaplan Medical Center, Rehovot, Israel. Affiliated to The School of Medicine, Hebrew University and Hadassah, Jerusalem.
    Besides the systemic immune deficiency, a sectorial default in immune control may occur in immunocompetent subjects. This regional immune defect can appear and remain confined to differently damaged skin areas, lately labeled immunocompromised districts (ICDs). An ICD is a skin area more vulnerable than the rest of the body for genetic or acquired reasons. Read More

    [A woman with purple-red nodules in an oedematous arm].
    Ned Tijdschr Geneeskd 2014 ;158:A7810
    Antoni van Leeuwenhoek, Amsterdam.
    A woman with postmastectomy lymphoedema presented with purple-red nodules on the right upper arm. Histopathology of a skin biopsy showed a cutaneous angiosarcoma. Angiosarcoma arising in an oedematous arm is called the Stewart-Treves syndrome and is a rare and late complication of breast cancer treatment. Read More

    Distant metastases in a young woman with Stewart-Treves syndrome demonstrated by an FDG-PET/CT scan.
    Clin Nucl Med 2014 Nov;39(11):975-6
    From the *Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; †Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; and ‡School of Medicine, China Medical University, Taichung, Taiwan.
    This 17-year-old woman had chronic congenital lymphedema in the left lower extremity since childhood. She underwent surgeries to remove excessive lymphedematous tissues more than 15 times previously. Histopathology of the specimen from the recent surgery revealed angiosarcoma; therefore, FDG-PET/CT scan was arranged to determine the extent of tumor spread, and distant metastases were discovered. Read More

    Cutaneous epithelioid clear cells angiosarcoma in a young woman with congenital lymphedema.
    Case Rep Pathol 2013 3;2013:931973. Epub 2013 Sep 3.
    Department of Pathology, Tours University Hospital, 37044 Tours, France.
    Angiosarcomas are rare aggressive neoplasms that can occur secondary to chronic lymphedema (Stewart-Treves syndrome). Although secondary angiosarcomas are commonly described after-mastectomy and/or after-radiotherapy, few cases have been reported in association with chronic lymphedema of congenital origin. We report the clinical, pathological, and cytogenetic findings in a case of cutaneous epithelioid clear cells angiosarcoma that occurred in a 21-year-old woman with hemibody congenital lymphedema. Read More

    Stewart-Treves syndrome: a case report.
    Ann R Coll Surg Engl 2013 Jul;95(5):e80-2
    Memorial Sloan-Kettering Cancer Center, 1,275 York Avenue, Suite A342, New York, NY 10065, USA.
    We present a case of chronic lymphoedema that progressed to Stewart-Treves syndrome in a 63-year-old woman with a previous modified radical mastectomy, associated lymph node dissection, chemotherapy and radiotherapy. While producing stabilisation of most cutaneous lesions initially, chemotherapeutic treatment of the angiosarcoma did not prevent subsequent metastasis and patient death. We urge vigilance and regular follow-up appointments for patients following a mastectomy with chronic lymphoedema to facilitate prevention or early treatment of this devastating syndrome. Read More

    Malignant vascular tumours associatedwith the breast: a study of 7 cases.
    J Pak Med Assoc 2013 May;63(5):646-9
    Department of Pathology and Microbiology, Faculty of Health Sciences, Medical College, Aga Khan University Hospital, Karachi, Pakistan.
    Angiosarcomas account for less than 0.05% of the malignant neoplasms of the breast. We present here 7 cases of malignant vascular neoplasms of the breast, including 2 cases of postmastectomy Stewart-Treves syndrome. Read More

    Detection of recurrent cutaneous angiosarcoma of lower extremity with (18)f-fluorodeoxyglucose positron emission tomography-computed tomography: report of three cases.
    Indian J Dermatol 2013 May;58(3):242
    Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
    Cutaneous angiosarcomas (CAS) are uncommon, aggressive tumours. Very rarely, they arise from the lower extremity. Such tumours are usually associated with chronic lymphedema, a phenomenon known as Stewart-Treves Syndrome. Read More

    Composite hemangioendothelioma and its classification as a low-grade malignancy.
    Am J Dermatopathol 2013 Jun;35(4):517-22
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, FL 33612, USA.
    Hemangioendotheliomas are vascular neoplasms occupying a spectrum of biological potential ranging from benign to low-grade malignancy. Composite hemangioendothelioma (CH) is one of the less commonly encountered variants exhibiting a mixture of elements of other hemangioendothelioma subtypes, such as epithelioid, retiform, and spindle cell. Some authors have identified areas histopathologically equivalent to angiosarcoma within CH, raising the question of the true nature of this neoplasm. Read More

    Mantle cell lymphoma relapsing at the lymphedematous arm.
    Mediterr J Hematol Infect Dis 2013 16;5(1):e2013016. Epub 2013 Feb 16.
    Departments of Hematology, Catholic University, Rome.
    Lymphedema (LE) is a chronic medical condition characterized by lymphatic fluid retention, resulting in tissue swelling. Cancer treatments involving lymph nodes can damage lymph drainage routes, causing accumulation of lymph fluid in the interstitial tissue of related limbs and body areas and secondary LE. Basically, the LE has a negative impact on physical and mental quality of life. Read More

    Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries.
    Chin Med J (Engl) 2013 Jan;126(2):231-7
    Department of General, Oncologic and Vascular Surgery, Military Health Service Institute, Warsaw, Poland.
    Background: The development of angiosarcoma in oedematous tissue is referred to as Stewart-Treves syndrome (STS). This rare and fatal complication is associated with chronic post mastectomy lymphoedema and radiotherapy for breast cancer. Angiosarcoma spread is facilitated by the formation of blood vessels (angiogenesis) and lymph vessels (lymphangiogenesis). Read More

    Two cases of cutaneous angiosarcoma developed after breast cancer surgery.
    Case Rep Dermatol 2012 Sep 14;4(3):247-9. Epub 2012 Sep 14.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Several randomized trials have shown that breast-conserving therapy (BCT) is as effective as mastectomy and should be a standard treatment for early-stage breast cancer. Recently, there has been an increase in reports of angiosarcoma (AS) after BCT. Herein, we report a case of AS which developed after BCT and a case of Stewart-Treves syndrome with a focus on lymphedema. Read More

    Angiosarcoma in a patient with congenital nonhereditary lymphedema.
    Cutis 2012 Nov;90(5):248-51
    Divison of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
    Angiosarcoma is an uncommon but aggressive tumor of endothelial origin that may occur in the upper extremities of patients with postmastectomy lymphedema (Stewart-Treves syndrome) as well as in other regions. We present an unusual case of angiosarcoma associated with congenital nonhereditary lymphedema in an 18-year-old man. Our case underscores the need for a careful clinical examination and shows the importance of appropriate sampling and thorough pathologic examination of suspicious areas to exclude the presence of a malignant process. Read More

    Decongestion improves cell-mediated immunity in postmastectomy arm lymphoedema: a pilot study.
    J Eur Acad Dermatol Venereol 2013 Dec 23;27(12):1579-82. Epub 2012 Jul 23.
    Department of Dermatology and Allergology, Szeged University, Szeged, Hungary, and Dermatological Research Group, Hungarian Academy of Sciences, Szeged, Hungary.
    Background: Chronic lymphoedematous limbs have an increased propensity for infections and primary or secondary malignant tumours. It has been attributed to suppressed delayed-type hypersensitivity measured in lymphoedemas related to Stewart-Treves syndrome, Kaposi's sarcoma or breast cancer treatment. Cell-mediated immunity is an effective defence mechanism against bacteria, fungi, viruses and tumour cells. Read More

    A Stewart-Treves syndrome of the lower limb.
    Dermatol Online J 2012 Jun 15;18(6):14. Epub 2012 Jun 15.
    We report a case of a Stewart-Treves syndrome of the lower limb. The tumor is best described in the upper limb following breast cancer treatment but a small number of cases have arisen in lymphedema of the lower limb. Electrochemotherapy could be useful in the palliative treatment of this lymphangiosarcoma. Read More

    Stewart-Treves syndrome: pathogenesis and management.
    J Am Acad Dermatol 2012 Dec 8;67(6):1342-8. Epub 2012 Jun 8.
    Dermatology and Pathology, New Jersey Medical School, Newark, New Jersey 07103-2714, USA.
    Stewart-Treves syndrome is a malignancy that arises within chronic lymphedema. Although classically described as a consequence of radical mastectomy, this lymphangiosarcoma has been documented to occur in cases of congenital and other causes of chronic secondary lymphedema. The development of this aggressive lymphangiosarcoma at sites of chronic lymphedema renders it a possible model for Kaposi sarcoma. Read More

    Stewart-Treves syndrome.
    Radiol Case Rep 2012 7;7(4):693. Epub 2015 Dec 7.
    Stewart-Treves syndrome is a rare cutaneous angiosarcoma with a poor prognosis. Physicians must be aware of this lethal syndrome, especially in patients who have been treated for breast cancer with radiation and lymph-node dissection (such as the case reported here). Patients who develop unexplained enlarging plaques of coalescing purple papules should have immediate biopsy for early diagnosis of Stewart-Treves syndrome. Read More

    [Secondary angiosarcomas after conservation treatment for breast cancers].
    Klin Onkol 2011 ;24(5):382-8
    Radioterapeutické a onkologické oddelení, FN Plzen.
    Backgrounds: The cancerogenic effect of ionizing radiation was documented just several years after it started to be used as a treatment option. Ionizing radiation produces a small but detectable risk of carcinoma as well as bone and soft tissue sarcomas. Over the past 20 years angiosarcomas arising from the area of the irradiated breast have been reported with increasing frequency as the number of women undergoing the breast conserving surgery with consecutive radiotherapy has increased also. Read More

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