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    5761 results match your criteria Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

    1 OF 116

    [Severe cutaneous drug reactions in children].
    Hautarzt 2017 Sep 20. Epub 2017 Sep 20.
    Dokumentationszentrum schwerer Hautreaktionen (dZh), Universitätsklinik für Dermatologie und Venerologie, Hauptstr. 7, 79104, Freiburg, Deutschland.
    Among severe drug reactions in children, besides Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), a specific form of hypersensitivity syndrome which is nowadays known as "drug reaction with eosinophilia and systemic symptoms" (DRESS) has to be mentioned. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as a drug reaction, only about 75% of all cases are actually caused by medications and in children it is only about 50%. Read More

    Minor Salivary Gland Transplantation for Severe Dry Eyes.
    Cornea 2017 Sep 15. Epub 2017 Sep 15.
    *Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; and †Department of Pathology, LIM 14, São Paulo University School of Medicine, São Paulo, Brazil.
    Dry eye is a multifactorial disease comprising a wide spectrum of ocular surface alterations and symptoms of discomfort. In most patients with aqueous-deficient dry eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage. However, in severe dry eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness. Read More

    Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation.
    J Biol Chem 2017 Sep 15. Epub 2017 Sep 15.
    University of California Irvine, United States
    During tissue development, transcription factors bind regulatory DNA regions called enhancers, often located at great distances from the genes they regulate, to control gene expression. The enhancer landscape during embryonic stem cell differentiation has been well characterized. By contrast, little is known about the shared and unique enhancer regulatory mechanisms in different ectodermally derived epithelial cells. Read More

    Mucocutaneous Inflammation in the Ikaros Family Zinc Finger 1 (IKZF1) - keratin 5 specifc transgenic mice.
    Allergy 2017 Sep 15. Epub 2017 Sep 15.
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Background: Our genome-wide association study documented an association between cold medicine related Stevens-Johnson syndrome / toxic epidermal necrolysis (CM-SJS/TEN) and Ikaros Family Zinc Finger 1 (IKZF1). Few studies examined biological and pathological functions of IKZF1 in mucosal immunity. We hypothesized that IKZF1 contributes to the mucocutaneous inflammation. Read More

    Drug-induced Stevens-Johnson syndrome in Indian population: A multicentric retrospective analysis.
    Niger J Clin Pract 2017 Aug;20(8):978-983
    Department of Pharmacology, Govt. Medical College, Bhavnagar, Gujarat, India.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening hypersensitivity reactions mainly caused by drugs. Data on incubation period, hospital stay, and outcome for HIV-positive patients are sparse. Role of corticosteroids in their management is still controversial. Read More

    Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13: 01 allele in the Thai population.
    Pharmacogenet Genomics 2017 Sep 6. Epub 2017 Sep 6.
    Departments of aPediatrics, Division of Pediatric DermatologybMedicine, Division of Dermatology, Skin and Allergy Research UnitcMedicine, Division of Allergy and Clinical Immunology, Skin and Allergy Research Unit, Faculty of Medicine, Chulalongkorn UniversitydLaboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC)eDepartment of Pathology, Division of Pharmacogenomics and Personalized MedicinefDepartment of Medicine, Division of DermatologygDepartment of Medicine, Division of Allergy Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol UniversityhThe Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, BangkokDepartments of iPharmacologyjMedicine, Faculty of Medicine, Khon Kaen University, Khon KaenkSchool of Pharmaceutical Sciences, University of Phayao, PhayaolPharmacy Department, Phrae Hospital, Phrae, Thailand.
    Objectives: A previous publication in Chinese leprosy patients showed that the HLA-B*13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether HLA-B*13:01 is a valid marker for prediction of dapsone-induced drug hypersensitivity reactions in other ethnicities or nonleprosy patients. The aim of this study is to investigate whether there is an association between HLA genotypes and dapsone-induced severe cutaneous adverse reactions (SCARs) in nonleprosy patients.

    Patients And Methods: HLA-B genotypes of 15 patients with dapsone-induced SCARs (11 drug reaction with eosinophilia and systemic symptoms, four Stevens-Johnson syndrome/toxic epidermal necrolysis), 29 control patients, and 986 people from the general Thai population were determined by the reverse PCR sequence-specific oligonucleotides probe. Read More

    Autoimmune Progesterone Dermatitis Presenting as Stevens-Johnson Syndrome.
    Obstet Gynecol 2017 Oct;130(4):881-884
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Naval Medical Center San Diego, San Diego, California.
    Background: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression.

    Case: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. Read More

    Successful Use of Cyclosporin A for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Three Children.
    Pediatr Dermatol 2017 Sep;34(5):540-546
    Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts.
    Background/objectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are medical emergencies. Mainstays of treatment include removal of the offending agent, supportive care, and wound care. The use of immunosuppressive agents such as corticosteroids and intravenous immunoglobulin (IVIg) is controversial. Read More

    Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Biol Pharm Bull 2017 ;40(9):1576-1580
    Division of Medicinal Safety Science, National Institute of Health Sciences.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Recent studies have revealed that the prevalence of SJS/TEN is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs). However, non-genetic factors contributing to the etiology of SJS/TEN are largely unknown. Read More

    Association between infection and severe drug adverse reactions: an analysis using data from the Japanese Adverse Drug Event Report database.
    Eur J Clin Pharmacol 2017 Aug 22. Epub 2017 Aug 22.
    Division of Medicinal Safety Science, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo, 158-8501, Japan.
    Purpose: It has been reported recently that immune reactions are involved in the pathogenesis of certain types of adverse drug reactions (ADRs). We aimed to determine the associations between infections and drug-induced interstitial lung disease (DILD), rhabdomyolysis, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), or drug-induced liver injury (DILI) using a spontaneous adverse drug event reporting database in Japan.

    Methods: The reported cases were classified into three categories (anti-infectious drug group, concomitant infection group, and non-infection group) based on the presence of anti-infectious drugs (either as primary suspected drug or concomitant drug) and infectious disease. Read More

    Mycoplasma pneumoniae-induced rash and mucositis: a recently described entity.
    BMJ Case Rep 2017 Aug 22;2017. Epub 2017 Aug 22.
    Department of Dermatology and Venereology, Hospital de Braga, Braga, Portugal.
    Mycoplasmapneumoniae is a common cause of respiratory infections. Although most cases are mild, some patients have extrapulmonary complications including mucocutaneous eruptions including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and erythemamultiforme (EM). Recently, a new entity, called M. Read More

    Amoxycillin and clavulanic acid induced Stevens-Johnson syndrome: A case report.
    EXCLI J 2017 18;16:748-751. Epub 2017 May 18.
    Baqai Medical University, Karachi, Pakistan.
    Stevens-Johnson syndrome (SJS) is an immune mediated hypersensitivity reaction. Significant involvement of oral, nasal, eye, vaginal, urethral, GI and lower respiratory tract mucous membrane may develop. It is usually a reaction due to a medication or due to an infection. Read More

    Collaboration in pharmacovigilance: lamotrigine and fatal severe cutaneous adverse reactions - a review of spontaneous reports.
    Ther Clin Risk Manag 2017 20;13:897-903. Epub 2017 Jul 20.
    Clinical Safety and Post-marketing Surveillance, GlaxoSmithKline KK, Tokyo, Japan.
    Pharmacovigilance presents many challenges, particularly when managing unpredictable, rare conditions, eg, severe cutaneous adverse reactions (SCARs). Such rare events are often only detected from spontaneous reports, which present their own limitations, particularly during a prolonged global launch schedule. GlaxoSmithKline's routine pharmacovigilance includes regular reviews of global adverse event (AE) reports and aggregate data from a central safety database. Read More

    Incidence, causative drugs, and economic consequences of drug-induced SJS, TEN, and SJS-TEN overlap and potential drug-drug interactions during treatment: a retrospective analysis at an Indonesian referral hospital.
    Ther Clin Risk Manag 2017 21;13:919-925. Epub 2017 Jul 21.
    Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening adverse drug reactions (ADRs) that are commonly caused by medications. Apart from their contribution to morbidity and mortality, these diseases may also present substantial consequences on health care resources. In this study, we aimed to identify the incidence, causative drugs, and economic consequences of these serious ADRs and potential drug-drug interactions (DDIs) during treatment. Read More

    Pseudomelanomas Following Stevens-Johnson Syndrome.
    Am J Dermatopathol 2017 Jul 26. Epub 2017 Jul 26.
    *Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Australia; †School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; and ‡Department of Dermatology, Charles Gairdner Hospital, Perth, Australia.
    In this report, we present a novel case of pseudomelanoma, similar to that seen in a recurrent/traumatized nevus, in pre-existing nevi in a 36-year-old man a few months after recovering from an episode of severe Stevens-Johnson syndrome. The mechanism responsible for the atypical transformation of these nevi is likely the release of cytokines and growth factors in the microenvironment during the repair/regeneration process. It is important to be aware of this phenomenon, and specific inquiry about potential recent blistering skin disorder in addition to the other causes of trauma should be made when dealing with cases of pseudomelanoma to avoid misdiagnosis. Read More

    Role of Scleral Contact Lenses in Management of Coexisting Keratoconus and Stevens-Johnson Syndrome.
    Cornea 2017 Oct;36(10):1267-1269
    *Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, India; and †Bausch & Lomb Contact Lens Centre, L V Prasad Eye Institute, Hyderabad, India.
    Purpose: To report the rare coexistence of keratoconus and Stevens-Johnson syndrome (SJS) managed with scleral contact lenses (ScCLs).

    Methods: This is a retrospective case series. Five patients (9 eyes) who had coexisting SJS and corneal ectasia were identified from the database during the 2-year period. Read More

    Phenytoin-induced Stevens-Johnson syndrome with myocarditis: a rare case report.
    Int Med Case Rep J 2017 10;10:229-231. Epub 2017 Jul 10.
    Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India.
    Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Read More

    Incidence of cutaneous adverse drug reactions among medical inpatients of Sultanah Aminah Hospital Johor Bahru.
    Med J Malaysia 2017 Jun;72(3):151-156
    Hospital Sultanah Aminah, Department of Dermatology, Johor Bahru, Johor, Malaysia.
    Introduction: Cutaneous adverse drug reactions (cADRs) are common. There are only few studies on the incidence of cADRs in Malaysia.

    Objective: To determine the incidence, clinical features and risk factors of cADRs among hospitalized patients. Read More

    Post-medication Stevens-Johnson syndrome in a girl hospitalized for a norovirus and rotavirus infection.
    Rom J Morphol Embryol 2017 ;58(2):681-683
    Department of Pediatrics, "Vasile Goldis" Western University of Arad, Romania;
    Stevens-Johnson syndrome (SJS) is a cutaneous mucosal disorder characterized by extended necrosis and detachment of the epidermis affecting <10% of the body surface, caused by drugs or infections. The authors report a case of a girl with Depakine resistant epilepsy, who develops a SJS in the third week of introducing lamotrigine. The girl also presents an acute diarrheal disease with double viral etiology - rotavirus and norovirus. Read More

    Bedside diagnostics in dermatology: Parasitic and noninfectious diseases.
    J Am Acad Dermatol 2017 Aug;77(2):221-230
    Department of Dermatology, Pathology, and Infectious Diseases, University of Iowa, Iowa City, Iowa.
    In addition to aiding the diagnosis of viral, bacterial, and fungal diseases, mineral oil preparation, Tzanck smear, and other techniques can be used to diagnose parasitic infections, neonatal pustular dermatoses, blistering diseases, Stevens-Johnson syndrome, and a plethora of other benign and malignant conditions, including granulomatous diseases and tumors. In many cases, these techniques are specific, reliable, and easy to perform and interpret. In others, a certain amount of training and expertise are required. Read More

    Cefepime Associated With Phenytoin Induced Stevens-Johnson Syndrome.
    Am J Ther 2017 Jul/Aug;24(4):e481-e484
    1Pharmacy Department, Gerencia de Atención Integrada, Albacete, Spain; and2Surgical Intensive Care Unit, Gerencia de Atención Integrada, Albacete, Spain.
    We describe a recent case of Stevens-Johnson Syndrome. A 49-year-old man was admitted to the Intensive Care Unit of an Anaesthesia and Resuscitation Department because of a Fournier gangrene that derived in a sepsis, ventilator-associated pneumonia, and renal failure. He was under treatment with cefepime and suffered a generalized status epilepticus, so started treatment with phenytoin. Read More

    Impact of glutathione transferases genes polymorphisms in nevirapine adverse reactions: a possible role for GSTM1 in SJS/TEN susceptibility.
    Eur J Clin Pharmacol 2017 Jul 8. Epub 2017 Jul 8.
    Department of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
    Purpose: Nevirapine (NVP) is used in developing countries as first-line treatment of HIV infection. Unfortunately, its use is associated with common serious adverse drug reactions, such as liver toxicity and the most severe and rare Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). GSTT1 and GSTM1 genes code for enzymes involved in the metabolism of a wide range of drugs. Read More

    Ocular surface cytokine profile in chronic Stevens-Johnson syndrome and its response to mucous membrane grafting for lid margin keratinisation.
    Br J Ophthalmol 2017 Jul 8. Epub 2017 Jul 8.
    R.S. Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO Block, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
    Background: To study the tear cytokine and the conjunctival and oral mucosal marker profile in chronic ocular Stevens-Johnson syndrome (SJS) and their alteration following mucous membrane grafting (MMG) for lid margin keratinisation (LMK).

    Methods: In a 1-year prospective study, SJS cases (n=25) and age-matched/sex-matched healthy controls (n=25) were recruited. Tear specimen (Schirmer's strip), conjunctival and oral mucosal imprints were collected from controls and SJS cases pre-MMG and post-MMG (at first follow-up, n=17). Read More

    Successful treatment of toxic epidermal necrolysis using plasmapheresis: A prospective observational study.
    J Crit Care 2017 Jul 1;42:65-68. Epub 2017 Jul 1.
    Department of Emergency Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China. Electronic address:
    Toxic epidermal necrolysis (TEN) is a rare, severe, life-threatening skin disease and it requires urgent critical care, including admission to the intensive care unit (ICU). It is characterized by fatal sequelae and high mortality. Currently, insufficient evidence exists to support the use of any systemic adjuvant therapy, such as cyclophosphamide, intravenous immunoglobulin (IVIg), or corticosteroids. Read More

    A Novel Approach To Sealing The Denuded Dermis of the Abdominal Wall With A Negative Pressure Wound Device After A Decompressive Laparotomy.
    J Burn Care Res 2017 Jun 28. Epub 2017 Jun 28.
    From the *Department of Surgery, Maricopa Integrated Health System, Phoenix, AZ; †Arizona Burn Center, Department of Surgery, Maricopa Integrated Health System, Phoenix, AZ.
    The open abdomen is a well-known technique that is applied in a wide variety of clinical situations, including treatment of abdominal compartment syndrome, damage control laparotomy, and severe intraabdominal sepsis. Disease states such as Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis or extensive deep partial and/or full-thickness torso burns involving the abdomen often result in a complete epidermal and partial dermal loss. When ABThera Open Abdomen Negative Pressure Wound Therapy is attempted in these patients, the exposed subcutaneous tissue rarely allows for an adequate seal between the adhesive barrier and the denuded skin. Read More

    Delayed-type hypersensitivity reactions induced by proton pump inhibitors: A clinical and in vitro T-cell reactivity study.
    Allergy 2017 Jun 28. Epub 2017 Jun 28.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou and Taipei, Taiwan.
    Background: Proton pump inhibitors (PPIs) have been known to induce type I hypersensitivity reactions. However, severe delayed-type hypersensitivity reactions (DHR) induced by PPI, such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug rash with eosinophilia and systemic symptoms (DRESS), are rarely reported. We conducted a study of a large series of PPI-related DHR, followed up their tolerability to alternative anti-ulcer agents, and investigated the T-cell reactivity to PPI in PPI-related DHR patients. Read More

    The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation.
    Allergol Int 2017 Jun 22. Epub 2017 Jun 22.
    Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan. Electronic address:
    Background: In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage. In addition, there are no reported prognostic biomarkers of disease severity in drug eruptions. Read More

    Things that could be Mycoplasma pneumoniae.
    J Infect 2017 Jun;74 Suppl 1:S95-S100
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Immunology and Rheumatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address:
    M. pneumoniae infection gives rise to a wide variety of manifestations. The pathogenesis of secondary manifestations is not always known. Read More

    Ciclosporin Use in Epidermal Necrolysis Is Associated with an Important Mortality Reduction: Evidence from Three Different Approaches.
    J Invest Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Clinical Pharmacology Unit, Príncipe de Asturias University Hospital, Department of Biomedical Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain. Electronic address:
    Several immunomodulatory agents are used in the treatment of Epidermal Necrolysis (EN), but evidence of their efficacy is limited. The Autonomous Community of Madrid has two reference Burn Units (BUs) to which all patients with EN are referred to. One BU has mostly used ciclosporin (CsA), while the other has used non-CsA therapies (mainly high-dose intravenous immunoglobulin). Read More

    Letter to the Editor concerning the article "Long term complications of Stevens-Johnson syndrome/Toxic epidermal necrolysis: The spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multi-disciplinary follow up.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Sunnybrook Health Sciences Centre - Division of Dermatology, Department of Medicine, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada.
    We read with great interest, the review paper by Lee et al. on the long term complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. We would like to congratulate the authors on this important and excellent overview. Read More

    Association between the HLA-B alleles and carbamazepine-induced SJS/TEN: A meta-analysis.
    Epilepsy Res 2017 Sep 3;135:19-28. Epub 2017 Jun 3.
    Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:
    Purpose: From our current understanding, the association between the human leukocyte antigen (HLA), HLA-B*1502, and carbamazepine(CBZ)-induced Stevens-Jonson syndrome and toxic epidermal necrolysis (SJS/TEN) in the Asian population is quite clear. However the relationship between other HLA-B alleles and CBZ-induced severe cutaneous adverse drug reactions (SCADRs) remains unclear. We aimed to identify other non-HLA-B*1502 alleles in patients with CBZ-induced SCADRs through a meta-analysis. Read More

    Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature.
    Case Rep Dermatol 2017 May-Aug;9(2):1-7. Epub 2017 May 8.
    Department of Dermatology and Venereology, Erasme Hospital, ULB, Brussels, Belgium.
    Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group). Read More

    Graft versus host disease: what should the oculoplastic surgeon know?
    Curr Opin Ophthalmol 2017 Sep;28(5):499-504
    University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose Of Review: To provide a concise review of the oculoplastic manifestations of ocular graft versus host disease (GVHD), and to discuss their management.

    Recent Findings: Ocular GVHD occurs as a common immune-mediated complication of hematopoietic stem cell transplantation that presents as a Stevens-Johnson-like syndrome in the acute phase or a Sjögren-like syndrome in the chronic phase. Cicatricial conjunctivitis may be underreported in ocular GVHD. Read More

    Tailoring of recommendations to reduce serious cutaneous adverse drug reactions: a pharmacogenomics approach.
    Pharmacogenomics 2017 Jun 8;18(9):881-890. Epub 2017 Jun 8.
    Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way, 11-03, Helios, Singapore 138667, Singapore.
    The Health Sciences Authority launched a pharmacogenetics initiative in 2008 to facilitate evaluation of pharmacogenetics associations pertinent for Chinese, Malays and Indians in Singapore. The aim was to reduce the incidence and unpredictability of serious adverse drug reactions, with a focus on serious skin adverse drug reactions. This paper describes the gathering of evidence and weighing of factors that led to different genotyping recommendations for HLA-B*15:02 with carbamazepine and HLA-B*58:01 with allopurinol, despite both having strong genetic associations. Read More

    Oxcarbazepine-induced Stevens-Johnson syndrome: a pediatric case report.
    Oxf Med Case Reports 2017 Jun 1;2017(6):omx028. Epub 2017 Jun 1.
    Department of Pediatric Allergy and Immunology, Trakya University Medical School, Edirne, Turkey.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are two rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions and mucous membrane erosions. Anti-epileptic drugs are highly suspected to be the causative agents. Although carbamazepine (CBZ) is the most associated anti-epileptic drug, oxcarbazepine (OXC), which is a monohydrated derivative of CBZ, is proposed to be safer because of the different metabolism of the two drugs. Read More

    Aprepitant for refractory nivolumab-induced pruritus.
    Lung Cancer 2017 Jul 27;109:58-61. Epub 2017 Apr 27.
    Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.
    Although substantial progress has been made in the treatment of non-small-cell lung cancer (NSCLC) patients with immune checkpoint inhibitors (ICIs), severe immune-related adverse events (irAEs) sometimes occur. Here, we report a case of severe refractory pruritus after Stevens-Johnson syndrome (SJS) in a patient with NSCLC treated with nivolumab. The patient was a 76-year-old Japanese woman with advanced NSCLC treated with nivolumab. Read More

    Life-threatening Skin Disorders Treated in the Burn Center: Impact of Health care-associated Infections on Length of Stay, Survival, and Hospital Charges.
    Clin Plast Surg 2017 Jul 26;44(3):597-602. Epub 2017 Apr 26.
    Department of Surgery, University of North Carolina School of Medicine, 7038 Burnett-Womack, Campus Box 7195, Chapel Hill, NC 27599, USA. Electronic address:
    This article reviews a single burn center experience with life-threatening skin disorders, over a 10-year period. It explores the incidence of health care-associated infections and the impact on length of stay, hospital charges, and mortality. Read More

    Burn Center Care of Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Clin Plast Surg 2017 Jul;44(3):583-595
    Department of Surgery, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Room D712, 1075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. Electronic address:
    Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, life-threatening, cutaneous drug reactions. Medications are the most common cause, although an infection may be responsible. A link between genetics and certain medications has been established. Read More

    HLA-A*31: 01 and HLA-B*15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population.
    Pharmacogenet Genomics 2017 Jul;27(7):275-278
    aDepartment of Medicine, Division of Neurology bDepartment of Genetics and Molecular Biology Programme, Institute of Biological Sciences, Faculty of Science cDepartment of Medicine, Division of Dermatology, Faculty of Medicine, University of Malaya, Kuala Lumpur dDepartment of Dermatology, Hospital Sultanah Bahiyah, Alor Setar, Kedah eSchool of Pharmacy, Monash University, Selangor, Malaysia.
    The majority of the carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis CBZ-SJS/TEN are associated with HLA-B*15:02 in Asian populations where this allele is common. In contrast, the association with HLA-A*31:01 is only reported in Japanese and Europeans. This study aimed to further investigate the association with HLA-A*31:01 besides HLA-B*15:02 in a multiethnic Malaysian population. Read More

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