7,249 results match your criteria Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Postmarket Assessment for Drugs and Biologics Used in Dermatology and Cutaneous Adverse Drug Reactions.

Dermatol Clin 2022 Jul 2;40(3):265-277. Epub 2022 Jun 2.

Division of Pharmacovigilance, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Postmarket surveillance is critical for the identification of rare safety risks, which are unlikely to be identified during clinical trials and the drug development program. Rare adverse drug reactions with the potential for serious outcomes, including fatalities, include the severe cutaneous adverse reactions of Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Dermatologists play an important role in the diagnosis of these serious drug reactions and contribute to drug safety by reporting cases of suspected cutaneous adverse drug reactions. Read More

View Article and Full-Text PDF

Clinical features and outcomes in children with Stevens-Johnson syndrome and toxic epidermal necrolysis.

J Dermatol 2022 Jun 17. Epub 2022 Jun 17.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei,Linkuo and Keelung, Taiwan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening cutaneous conditions. However, studies of pediatric SJS/TEN are limited. To investigate the causes, clinical course, outcomes and complications of SJS and TEN in children. Read More

View Article and Full-Text PDF

Epidermal necrolysis in the context of immuno-oncologic medication as well as kinase inhibitors and biologics.

J Dtsch Dermatol Ges 2022 06;20(6):777-786

German Center for the Documentation of Severe Skin Reactions (dZh), Department of Dermatologie, Medical Center and Medical Faculty - University of Freiburg, Germany.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, primarily drug-induced reactions of skin and mucosa. Since they differ in the extent of skin detachment but not in etiology, they are grouped together as epidermal necrolysis (EN). Due to nationwide registration, representative data are available at the German Center for the Documentation of Severe Skin Reactions (dZh). Read More

View Article and Full-Text PDF


Arerugi 2022 ;71(4):328-333

Department of Pediatrics, Kasugai Municipal Hospital.

We describe here the case of a 7-year-old male patient with Stevens-Johnson syndrome (SJS), which was suspected to be caused by treatment with tipepidine hibenzate (Asverin). The day after taking tipepidine hibenzate and L-carbocysteine (Carbocysteine DS) for relief of a cold, he began presenting with the following symptoms: fever above 38°C, wheezing, and decreased oxygen saturation. Two days later, mucous membrane rashes, such as erosions on the lips, eye mucosa, vulva, and blisters on the trunk appeared, and SJS was thus diagnosed. Read More

View Article and Full-Text PDF

Stevens-Johnson syndrome and toxic epidermal necrolysis associated with increased risk of developing psychiatric disorders: A retrospective population-based cohort study in Taiwan.

J Dermatol 2022 Jun 10. Epub 2022 Jun 10.

Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening adverse reactions to drugs and psychological sequelae are also observed to follow the trauma of widespread epidermal necrolysis. To delineate the association between SJS and TEN, and psychiatric disorders, we conducted a retrospective population-based cohort study by including 212 patients diagnosed with first-time SJS or TEN in Taiwan between 2000 and 2013 and 669 population controls. Adjusted hazard ratios were calculated after adjusting for sex, age, comorbidity in the form of Charlson comorbidity index, and facility level of care. Read More

View Article and Full-Text PDF

Infantile Stevens Johnson syndrome and toxic epidermal necrolysis: A systematic review of clinical features and outcomes in children ages 12 months and under.

Pediatr Dermatol 2022 Jun 8. Epub 2022 Jun 8.

Dermatology Program, Department of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA.

Background/objectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous hypersensitivity reactions that carry significant morbidity and mortality. While clinical features are well documented in adult and pediatric patients, infantile cases are rarely reported. Our objective was to synthesize clinical features and outcomes in this population. Read More

View Article and Full-Text PDF

Management of Drug-Induced Epidermal Necrolysis (DEN) in Pediatric Patients: Moving from Drug-Induced Stevens-Johnson Syndrome, Overlap and Toxic Epidermal Necrolysis to a Single Unifying Diagnosis of DEN.

Paediatr Drugs 2022 Jul 9;24(4):307-319. Epub 2022 Jun 9.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Pediatric Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threating blistering diseases triggered by medications that affect the skin and mucosae. Drug-induced epidermal necrolysis is a better term for medication-triggered cases because there is a spectrum of disease severity that otherwise is divided into the separate entities of SJS, overlap SJS/TEN, and TEN. This manuscript reviews the management of drug-induced epidermal necrolysis (DEN), including diagnosis, investigations to exclude differential diagnoses, and treatment. Read More

View Article and Full-Text PDF

Clinical characteristics and management of acute generalized exanthematous pustulosis with haemodynamic instability.

Skin Health Dis 2021 Dec 15;1(4):e74. Epub 2021 Nov 15.

Department of Dermatology University of Texas Southwestern Medical Center Dallas Texas USA.

Background: Acute generalized exanthematous pustulosis (AGEP) is a severe pustular drug eruption with rare reports of haemodynamic instability.

Objective: To describe the clinical characteristics, management, and outcomes of patients with AGEP-associated haemodynamic instability.

Methods: This retrospective case series identified adult patients diagnosed with AGEP who had haemodynamic instability from November 2012 to February 2020 that were seen at two academic teaching hospitals with roles as a burn centre and tertiary referral centre at the University of Texas Southwestern Medical Center in Dallas, TX USA. Read More

View Article and Full-Text PDF
December 2021

Analyzing excipient-related adverse events in antiseizure drug formulations.

Epilepsy Res 2022 May 23;184:106947. Epub 2022 May 23.

University of California, San Francisco, Department of Clinical Pharmacy, 490 Illinois Street Floor 3, San Francisco 94158, CA, United States. Electronic address:

There have been several reports that switching formulations of antiseizure medications (ASMs) has been associated with a deterioration of seizure control, seizure relapse or increased adverse effects. Considering recent findings that excipients, namely purported inactive ingredients, may nevertheless exert biological effects, it is possible that the variation in adverse event profile of antiseizure drugs may be related to differences in excipients. To test our hypothesis, we constructed a new research tool to connect FDA-compiled adverse event reports to the excipient in the medicine. Read More

View Article and Full-Text PDF

IFN-γ ELISpot in Severe Cutaneous Adverse Reactions to First-line Anti-tuberculosis Drugs in an HIV Endemic Setting.

J Invest Dermatol 2022 Jun 1. Epub 2022 Jun 1.

Division of Allergy and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa. Electronic address:

Severe cutaneous adverse reactions (SCARs) related to first-line anti-tuberculosis (FTLB) drugs are associated with high mortality and long-term morbidity. Oral sequential drug challenge (SDC), as a form of drug provocation testing, helps salvage therapy by identifying culprit drugs, but is associated with risk and is costly. IFN-γ ELISpot, an adjunctive in vitro diagnostic tool, may help guide risk-stratification approaches. Read More

View Article and Full-Text PDF

The Molting Man: Anasarca-Induced Full-Body Desquamation.

Cutis 2022 Apr;109(4):221-223

Dr. Kou is from Des Moines University College of Osteopathic Medicine, Iowa. Dr. Kolb is from Olmsted Medical Center, Rochester, Minnesota. Dr. Kelada is from Roseville Family Healthcare, California. Dr. Schmieder is from the Department of Dermatology, Orange Park Medical Center, Florida.

Blisters and subsequent desquamation of the skin in the presence of acute edema is a well-known clinical phenomenon. In this case report, we describe a new variant that we have termed anasarca-induced desquamation in a 50-year-old man with molting of the entire cutaneous surface after acute edema, in a setting of 40-lb weight gain over 5 days. Laboratory workup for infectious causes and punch biopsies of skin lesions ruled out Stevens-Johnson syndrome and staphylococcal scalded skin syndrome, which have a similar clinical presentation to anasarca-induced desquamation. Read More

View Article and Full-Text PDF

Graft-vs-host Disease and Toxic Epidermal Necrolysis Following Hematopoietic Stem Cell Transplantation.

Cutis 2022 02;109(2):E9-E12

Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa.

View Article and Full-Text PDF
February 2022

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: 11-year Demographic Clinical and Prognostic Characteristics.

Indian J Dermatol 2022 Jan-Feb;67(1):12-18

Department of Dermatology and Venereology, Ege University Medical Faculty, Izmir, Turkey.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life-threatening, severe drug reactions. Randomized studies on these diseases are difficult to perform.

Aims And Objectives: The purpose of this study was to summarize the demographic and clinical characteristics of patients with SJS and TEN in a tertiary hospital in Turkey. Read More

View Article and Full-Text PDF

Acute Onset of a Life-Threatening Skin Toxicity Due to Osimertinib: Severe Psoriasis Versus Toxic Epidermal Necrolysis.

Cureus 2022 Apr 26;14(4):e24513. Epub 2022 Apr 26.

Medicine, The University of British Columbia, Vancouver, CAN.

Osimertinib is a third-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor currently used as first-line systemic therapy for advanced EGFR mutant non-small cell lung cancer. Osimertinib is generally very well tolerated with only a 1% risk of grade 3-4 skin toxicity. Here we present a case of a 68-year-old Asian male with advanced EGFR exon 19 deletion non-small cell lung cancer. Read More

View Article and Full-Text PDF

Hyperacute Graft-Versus-Host Disease Mimicking Stevens-Johnson Syndrome in a Patient With Allogeneic Hematopoietic Stem Cell Transplantation.

Dermatol Pract Concept 2022 May 1;12(2):e2022073. Epub 2022 Apr 1.

Department of Dermatology and Venereology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.

View Article and Full-Text PDF

Management of oral mucosal lesions in salicylate sensitive stevens-Johnson syndrome - A case report.

Indian J Dent Res 2021 Oct-Dec;32(4):537-540

Department of Pediatric and Preventive Dentistry, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

In the present era, the use of drugs is an important paradigm of health care. Reactions to drugs range from minor cutaneous reactions to potentially lethal conditions like Stevens-Johnson syndrome. A 13-year-old, male patient, known case of Stevens-Johnson Syndrome was referred from the pediatric ward for the management of oral mucosal lesions, post consumption of the antibiotic combination of sulfamethoxazole and trimethoprim. Read More

View Article and Full-Text PDF

Modified technique for sutureless amniotic membrane transplantation in acute Stevens-Johnson syndrome using fibrin sealant.

Ocul Surf 2022 May 26;25:89-91. Epub 2022 May 26.

Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States. Electronic address:

View Article and Full-Text PDF

Severe Cutaneous Adverse Drug Reactions in Children: Epidemiological, Clinical and Etiological Aspects in Dermatology-Venereology Unit at National and Teaching Hospital of Cotonou.

West Afr J Med 2022 May;39(5):538-542

Service de dermatologie-vénérologie, Centre National Hospitalier et Universitaire de Cotonou, Faculté des Sciences de la Santé - Université d'Abomey-Calavi.

Background: The aim of this study was to describe the epidemiological, clinical and etiological aspects of severe cutaneous adverse drug reactions in children in dermatologyvenereology unit at National and Teaching Hospital of Cotonou.

Methods: A retrospective and descriptive study was carried out for 10 years in dermatology-venereology unit at the National and Teaching Hospital of Cotonou to document the epidemiological, clinical and etiological aspects of severe cutaneous adverse drug reactions in children. It included all children aged from 0 to 18 years with clinical diagnosis of severe cutaneous adverse drug reactions. Read More

View Article and Full-Text PDF

Bilateral Central Retinal Vein Occlusion and Stevens-Johnson Syndrome Associated with Coronavirus-19: A Case Report.

J Curr Ophthalmol 2022 Jan-Mar;34(1):121-123. Epub 2022 Apr 16.

Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Purpose: To report a case of bilateral central retinal vein occlusion (CRVO) associated with coronavirus-19 (COVID-19) infection.

Methods: A 43-year-old man presented to the emergency department with flu-like symptoms, severe erythema, a rash on his face, and respiratory distress. He was admitted to the intensive care unit, and the reverse transcriptase-polymerase chain reaction test was positive for the severe acute respiratory syndrome coronavirus-2 virus. Read More

View Article and Full-Text PDF

Oral and maxillofacial manifestations of human immunodefficiency virus infection.

L Benslama

J Stomatol Oral Maxillofac Surg 2022 May 23. Epub 2022 May 23.

Department of stomatology and maxillofacial surgery, AP-HP, DHU FAST, GH Pitié- Salpêtrière- Charles Foix, Paris F-75013, France. Electronic address:

Oral manifestations occur at all stages of human immunodeficiency virus (HIV) infection. Their clinical expressions and severity depend on the evolution of the infection and become critical at the stage of acquired immunodeficiency (AIDS). They are essentially infectious, tumoral, and, starting a few years ago, iatrogenic. Read More

View Article and Full-Text PDF

Osteo-odonto-keratoprosthesis according to Strampelli original technique: A retrospective study with up to 30 years of follow-up.

Am J Ophthalmol 2022 May 23. Epub 2022 May 23.

Department of Odontostomatologic and Maxillofacial Sciences, Head and Neck Department, Sapienza University of Rome, Italy.

Purpose: To describe clinical, anatomical, and visual outcomes obtained from a long-term follow-up of 59 patients who underwent osteo-odonto-keratoprosthesis (OOKP) using the original Strampelli technique.

Design: retrospective clinical cohort study.

Methods: 82 eyes of 59 patients who underwent OOKP surgery between 1969 and 2011 were included. Read More

View Article and Full-Text PDF

[HLA-B58.01 and allopurinol hypersensitivity renal vasculitis in a Chinese patient].

Rev Med Interne 2022 May 20. Epub 2022 May 20.

Centre de néphrologie et transplantation rénale, AP-HM, CHU de la Conception, 147, boulevard Baille, 13005 Marseille, France; C2VN, Inserm 1263, Institut national de la recherche agronomique (INRA) 1260, faculté de Pharmacie, Marseille, France.

Introduction: Allopurinol, widely used in the treatment of hyperuricemia and gout, has been shown to cause severe cutaneous reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, as well as systemic reactions such as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). The HLA-B*5801 allele is known to be a risk factor for severe cutaneous manifestations of hypersensitivity to allopurinol, mostly in Asian populations.

Observation: We report the observation of a 47-year-old Chinese patient, with no previous medical history, carrying the HLA-B*5801 allele, who developed an isolated allopurinol hypersensitivity necrotizing renal vasculitis without cutaneous manifestations. Read More

View Article and Full-Text PDF

Cutaneous Toxicities Associated with Immune Checkpoint Inhibitors: an Observational, Pharmacovigilance Study.

J Invest Dermatol 2022 May 18. Epub 2022 May 18.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD. Electronic address:

Cutaneous immune-related adverse events (cirAEs) are the most prevalent complication to arise from immunotherapy and cause significant morbidity. We aimed to determine the spectrum, timing, clinical features, and outcomes of cirAEs by conducting an observational pharmacovigilance study using VigiBase, the World Health Organization's global database of individual case safety reports from over 130 member countries (ClinicalTrials.gov, number NCT04898751). Read More

View Article and Full-Text PDF

Stevens-Johnson Syndrome Following Non-steroidal Anti-inflammatory Drugs: A Real-World Analysis of Post-marketing Surveillance Data.

Front Pediatr 2022 6;10:896867. Epub 2022 May 6.

Department of Pharmacy, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: The Stevens-Johnson syndrome (SJS) is a severe skin reaction to non-steroidal anti-inflammatory drugs (NSAIDs), and can even be life-threatening. However, there are still few real-world studies to compare the specific differences in the adverse effects of skin and mucosal invasion.

Methods: Disproportionality analysis and Bayesian analysis were devoted to data-mining of the suspected SJS after using NSAIDs based on the FDA's Adverse Event Reporting System (FAERS) from January 2004 to March 2021. Read More

View Article and Full-Text PDF

Associations of HLA genetic variants with carbamazepine-induced cutaneous adverse drug reactions: An updated meta-analysis.

Clin Transl Sci 2022 May 22. Epub 2022 May 22.

Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Aggregated risk of carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) with different HLA variants are unclear and limited in terms of the power of studies. This study aimed to assess the aggregated risk of CBZ-induced cADRs associated with carrying the following HLA variants: HLA-B*15:02, HLA-B*15:11, HLA-B*15:21, HLA-B*38:02, HLA-B*40:01, HLA-B*46:01, HLA-B*58:01, HLA-A*24:02, and HLA-A*31:01. Literature was searched in different databases following PRISMA guidelines. Read More

View Article and Full-Text PDF

Etanercept treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Ann Allergy Asthma Immunol 2022 May 19. Epub 2022 May 19.

Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address:

Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe cutaneous adverse reaction to drugs with considerable morbidity and mortality. Immunomodulators for SJS/TEN including systemic corticosteroids and intravenous immunoglobulin (IVIG) have been widely used in clinical practice. Emerging evidence suggested the therapeutic effects of tumor necrosis factor-α antagonists on SJS/TEN. Read More

View Article and Full-Text PDF

The assessment of severe cutaneous adverse drug reactions.

Aust Prescr 2022 Apr 1;45(2):43-48. Epub 2022 Apr 1.

McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

Severe cutaneous adverse drug reactions include Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalised exanthematous pustulosis. These eruptions are a type of delayed hypersensitivity reaction and can be life-threatening. The assessment of a severe cutaneous drug reaction requires a detailed clinical history and examination to identify the culprit drug and evaluate the allergy. Read More

View Article and Full-Text PDF

Platelet-rich fibrin a new approach in management of persistent oral ulcers in blistering skin diseases.

Wound Repair Regen 2022 May 19. Epub 2022 May 19.

Faculty of Dentistry, Cairo University, Cairo, Egypt.

The present study designed to evaluate the healing power of platelet-rich fibrin (PRF) in terms of pain control and mucosal repair. A randomised, controlled, pilot clinical trial was conducted on 16 patients randomly distributed with 1:1 allocation ratio into two groups. The treatment group received PRF minced and mixed with orabase and the control group received clobetasol propionate 0. Read More

View Article and Full-Text PDF

Microbial Keratitis in Patients With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Experience From a Tertiary Centre in Taiwan.

Cornea 2022 May 13. Epub 2022 May 13.

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Purpose: The purpose of this study was to analyze the clinical features, causative microorganisms, antibiotic susceptibility, and treatment outcomes in culture-proven microbial keratitis (MK) in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and to analyze the potential risk factors.

Methods: We reviewed the medical records of all patients with SJS/TEN who attended our department between 2009 and 2018. Patients with a diagnosis of MK who underwent corneal cultures were enrolled. Read More

View Article and Full-Text PDF