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    5894 results match your criteria Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

    1 OF 118

    The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison to the USA FDA Label.
    Clin Pharmacol Ther 2018 Mar 23. Epub 2018 Mar 23.
    Chang Gung Memorial Hospital, Linkou, Taiwan.
    Specific ethnic genetic backgrounds associated with risk of Stevens-Johnson syndrome/toxic epidermal necrolysis(SJS/TEN) especially in Asians. However, there have been no large cohort, multiple-country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998-2017. Read More

    [Severe skin reactions due to new medications].
    Hautarzt 2018 Mar 22. Epub 2018 Mar 22.
    Dokumentationszentrum schwerer Hautreaktionen (dZh), Universitätsklinik für Dermatologie und Venerologie, Hauptstr. 7, 79104, Freiburg, Deutschland.
    Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and a specific form of hypersensitivity syndrome which is nowadays called "drug reaction with eosinophilia and systemic symptoms" (DRESS) are severe, mainly drug-induced skin reactions. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as drug reaction, in total only about three quarters of the cases are actually caused by drugs. Read More

    Hemophagocytic lymphohistiocytosis in an infant with multiple triggers!!
    Asian J Transfus Sci 2018 Jan-Jun;12(1):85-88
    Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, New Delhi, India.
    Hemophagocytic lymphohistiocytosis (HLH) is a disorder of immune dysregulation secondary to a massive unregulated cytokine storm and its downstream consequences. HLH is being increasingly recognized as a cause of pyrexia of unknown origin, unexplained cytopenias, and hepatic dysfunction. However, this potentially treatable condition is often missed due to lack of suspicion, variable, and nonspecific presentations, inability to fulfil all the diagnostic criteria and availability of diagnostic tests in resource limited settings. Read More

    Mycoplasma pneumoniae-related erythema multiforme: clinical and histological features. A single center series of 33 cases compared to 100 cases induced by other causes.
    J Am Acad Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Dermatology department, AP-HP, Henri Mondor hospital, Créteil; EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), Université Paris-Est Créteil Val de Marne (UPEC), Creteil; Referral center for toxic bullous diseases, AP-HP, Henri Mondor hospital, Créteil; Université Paris Est-Créteil UPEC, Créteil.
    Background: Mycoplasma pneumoniae (MP) infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of MP-related EM (MP-EM) have been poorly described in the literature.

    Objective: To highlight differences between MP-EM and non-MP-EM. Read More

    Selective use of cyclosporine for Stevens-Johnson syndrome / toxic epidermal necrolysis may exclude patients with poor prognostic factors.
    J Invest Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:

    Toxic Epidermal Necrolysis: A Dermatologic Emergency and the Role of the Oral and Maxillofacial Surgeon.
    J Oral Maxillofac Surg 2018 Feb 23. Epub 2018 Feb 23.
    Associate Program Director, Department of Oral and Maxillofacial Surgery, Nassau University Medical Center, East Meadow, NY.
    Toxic epidermal necrolysis (TEN) is a rare and severe mucocutaneous disorder characterized by mucosal and epidermal necrosis and sloughing. This potentially life-threatening condition, together with the less severe Stevens-Johnson syndrome, is commonly caused by an immunologic reaction to medications and can lead to many long-term complications. The disorder initially presents with fever, malaise, and painful mucosal ulcerations (most commonly oral) but progresses to widespread cutaneous lesions. Read More

    Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients.
    J Immunol Res 2018 10;2018:2780272. Epub 2018 Jan 10.
    Department of Community Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    The∗allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. Thealleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement ofalleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. Read More

    Association Between HLA-B*1301 and Dapsone-Induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-analysis.
    JAMA Dermatol 2018 Mar 14. Epub 2018 Mar 14.
    Center of Excellence for Environmental Health and Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
    Importance: Dapsone-induced hypersensitivity syndrome (DHS) is a life-threatening adverse drug reaction. Based on available epidemiologic studies, HLA genotypes may play an important role in DHS.

    Objective: To assess the association between HLA-B*1301 and dapsone-induced cutaneous adverse drug reactions (cADRs). Read More

    Anterior segment optical coherence tomography findings in type I Boston keratoprosthesis.
    Arq Bras Oftalmol 2018 Jan-Feb;81(1):42-46
    Department of Ophthalmology and Visual Sciences, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Purpose: To report the results of high-resolution anterior segment optical coherence tomography of patients implanted with a type 1 Boston keratoprosthesis (KPro).

    Methods: The retrospective study cohort included 11 eyes of 11 patients (average age, 58.4 years; range, 34-83 years). Read More

    induced mucositis without rash in an 11-year-old boy.
    Clin Case Rep 2018 Mar 6;6(3):551-552. Epub 2018 Feb 6.
    Department of PediatricsSaint Barnabas Medical CenterLivingstonNew Jersey.
    is a frequent cause of childhood pneumonia, and extrapulmonary manifestations may be noted at the time of infection. Whilehas long been associated with Stevens-Johnson syndrome, a separate diagnostic entity,induced rash and mucositis (MIRM), has recently been proposed to better characterize the rash and severe mucositis that some patients exhibit. A subset of patients with MIRM will have mucositis without skin rash. Read More

    Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome.
    Obstet Gynecol 2018 Mar 8. Epub 2018 Mar 8.
    Departments of Obstetrics and Gynecology and Reproductive Endocrinology and Infertility, Naval Medical Center San Diego, San Diego, California.
    Background: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression.

    Case: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. Read More

    Epidermal necrolysis and autoimmune diseases: two more observations supporting the concept that "toxic" epidermal necrolysis can be "non-toxic".
    J Eur Acad Dermatol Venereol 2018 Mar 10. Epub 2018 Mar 10.
    Dermatology department, AP-HP, Henri Mondor hospital, Créteil, France.
    Toxic epidermal necrolysis (TEN, Lyell syndrome) and Stevens-Johnson syndrome are severe cutaneous adverse reactions to drugs characterized by epidermal necrolysis (EN). However, in 15% of cases, no causative drug is identified. In these cases, other triggers such as Mycoplasma pneumoniae have been described. Read More

    Overexpression of cytotoxic proteins correlates with liver function impairment in patients with drug reaction with eosinophilia and systemic symptoms (DRESS).
    Eur J Dermatol 2018 Feb;28(1):13-25
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
    Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterised by skin rash and multivisceral involvement. The liver is the organ most frequently affected and the degree of liver function impairment often correlates with the mortality rate of DRESS. We aimed to examine the expression of cytotoxic proteins, including soluble Fas ligand (sFasL), TNF-α, granulysin, perforin, and granzyme B in the sera and skin lesions of patients with DRESS and evaluate their clinical significance. Read More

    A Rare Case Report of Toxic Epidermal Necrolysis due to Ofloxacin.
    Curr Drug Saf 2018 Mar 2. Epub 2018 Mar 2.
    Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar - 364001 (Gujarat), India.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet uncleared. A 45-year-old male patient by chance on re-exposure to Ofloxacin developed severe cutaneous adverse drug reaction (SCADR), diagnosed with toxic epidermal necrolysis. His comorbid conditions and systemic complications of TEN were lead him to death. Read More

    Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review.
    Medicine (Baltimore) 2018 Jan;97(1):e9112
    Department of Children's Critical Care Medicine, Xin-Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Rationale: Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. SJS in children is not common but potentially serious disease. But the epidemiology of SJS in China is not well defined. Read More

    [Factors associated with the severity of acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis in sub-Saharan Africa].
    Ann Dermatol Venereol 2018 Feb 24. Epub 2018 Feb 24.
    Service de dermatologie et IST, CHU de Sylvanus Olympio, université de Lomé, BP 30785, Lomé, Togo.
    Aim: The purpose of this study was to identify risk factors associated with the severity of acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in sub-Saharan Africa.

    Patients And Method: A retrospective study was carried out at the dermatology department in collaboration with the ophthalmology department for SJS/TEN patients between January 2000 and December 2016 in Lomé (Togo). The severity of acute ocular involvement was evaluated using the Power classification, and the drug eruption score was assessed using de Bastuji-Garin classification. Read More

    Risks associated with lamotrigine prescription: a review and personal observations.
    Australas Psychiatry 2018 Feb 1:1039856218760733. Epub 2018 Feb 1.
    Scientia Professor of Psychiatry, University of New South Wales, Sydney, NSW, and; Professorial Fellow, Black Dog Institute, Randwick, NSW, Australia.
    Objectives: To detail some serious lamotrigine side effects and their management, and raise awareness about the possible lack of quality control of some brands of lamotrigine.

    Methods: A literature review is provided and some personal observations added.

    Results: While most psychiatrists are aware of the risks of Stevens-Johnson syndrome (SJS), awareness of two other serious side effects - toxic epidermal necrosis (TEN) and drug-related eosinophilia and systemic symptoms (DRESS) - is seemingly lower. Read More

    The use of cyclosporine for Stevens-Johnson syndrome-toxic epidermal necrolysis spectrum at the University of Louisville: A case series and literature review.
    Dermatol Online J 2018 01 1;24(1). Epub 2018 Jan 1.
    Division of Dermatology, University of Louisville School of Medicine, Louisville, Kentucky.
    Introduction: Cyclosporine therapy for Stevens-Johnson syndrome-toxic epidermal necrolysis (SJSTEN) was first reported in the literature by Renfro et al. in 1989. Herein we report an additional 4 cases of SJS-TEN treated with cyclosporine. Read More

    Vaccine-induced toxic epidermal necrolysis: A case and systematic review.
    Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.
    Division of Dermatology, University of California Los Angeles, Los Angeles, California.
    Background: Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are cutaneous hypersensitivityreactions that develop in response to specific triggers such as medications and certain infections. Vaccines, which undergo rigorous safety testing prior to use in humans, are a rare cause of SJS/TEN and little is known about the frequency of such events and corresponding pathogenesis.

    Objective: Herein, we discuss a case of suspected TEN in a 19-year-old woman who received the meningococcal B vaccine (the first report of such an association) and conduct a systematic review of the associated literature. Read More

    Direct costs of severe cutaneous adverse reactions in a tertiary hospital in Korea.
    Korean J Intern Med 2018 Feb 23. Epub 2018 Feb 23.
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
    Background/aims: There are only a few reports on the direct costs of severe cutaneous adverse reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), despite the tremendous negative impact these reactions can have on patients. We estimated the direct costs of treating SCARs.

    Methods: Patients admitted to a tertiary teaching hospital for the treatment of SCARs from January 1, 2005 to December 31, 2010 were included. Read More

    Treatments for Severe Cutaneous Adverse Reactions.
    J Immunol Res 2017 27;2017:1503709. Epub 2017 Dec 27.
    Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Severe cutaneous adverse reaction (SCAR) is life-threatening. It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. Read More

    Mycoplasma pneumoniae-associated Fuchs syndrome.
    Clin Case Rep 2018 Feb 22;6(2):434-435. Epub 2017 Dec 22.
    Internal Medicine DepartmentHurley Medical Center/Michigan State UniversityTwo Hurley Plaza, Ste 212Flint48503Michigan.
    Fuchs syndrome is a milder form of the Stevens-Johnson syndrome (SJS) spectrum with only mucosal involvement which can be triggered by Mycoplasma pneumonia (MP) infection. Treatment should be directed toward supportive care including ocular and mucous membrane care, fluids and nutritional support, and pain control. In addition, antibiotic and immunomodulatory treatments are discussed for this entity. Read More

    Stevens-Johnson syndrome/toxic epidermal necrolysis associated with zonisamide.
    Clin Case Rep 2018 Feb 20;6(2):258-261. Epub 2017 Dec 20.
    Department of Dermatology and Cutaneous SurgeryUniversity of South FloridaTampaFlorida.
    This report highlights zonisamide as a potential cause of serious cutaneous reactions as well as its cross-reactivity with other sulfonamides. Here, we present a case of SJS-TEN due to zonisamide, which was effectively treated with IVIg. Subsequently, the patient was transitioned to levetiracetam for seizure control. Read More

    ISMP Adverse Drug Reactions: Influenza Vaccine-Induced Stevens-Johnson Syndrome; Vilazodone-Induced Nightmares; Dabigatran-Induced Pustular Eruptions; Neurotoxic and Cardiotoxic Symptoms After Cannabis Concentrate Exposure; Rosuvastatin-Induced Skin Eruption.
    Hosp Pharm 2018 Feb 6;53(1):15-17. Epub 2017 Nov 6.
    Department of Pharmacy Practice, School of Pharmacy, Temple University, Philadelphia, PA, USA.
    The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Read More

    Ethosuximide-induced Stevens-Johnson syndrome: Beneficial effect of early intervention with high-dose corticosteroid therapy.
    J Dermatol 2018 Feb 11. Epub 2018 Feb 11.
    Department ofDermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
    We report two rare cases of childhood epilepsy patients who developed ethosuximide-induced Stevens-Johnson syndrome (SJS). Unlike typical SJS, the initial eruption of both patients presented well-demarcated, infiltrating firm papules mainly on the cheeks and the extensor aspects of the arms (case 1), and multiple vesicles on the soles and oral aphthosis (case 2), which closely mimicked viral exanthema. We diagnosed both patients with ethosuximide-induced SJS, based on the dosing period and the positive results of drug-induced lymphocyte stimulation test. Read More

    EyePrintPRO therapeutic scleral contact lens: indications and outcomes.
    Can J Ophthalmol 2018 Feb 28;53(1):66-70. Epub 2017 Sep 28.
    Kensington Eye Institute, Toronto, Ont; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.. Electronic address:
    Objective: To describe indications and outcomes of patients fitted with the EyePrintPRO therapeutic scleral lens.

    Methods: A database search of patients fitted with the EyePrintPRO from 2014 to 2016. Fourteen eyes of 10 patients were reviewed retrospectively. Read More

    Pediatric Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Halted by Etanercept.
    J Cutan Med Surg 2018 Feb 1:1203475418758989. Epub 2018 Feb 1.
    1 Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
    We report a case of an 11-year-old female with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) overlap, most likely triggered by sulfamethoxazole-trimethoprim, who was treated with the combination of methylprednisolone, cyclosporine, and etanercept. Her condition stabilized and her skin involvement did not progress after the addition of etanercept. To our knowledge, this is the first report of etanercept for pediatric SJS/TEN. Read More

    Chronic Ocular Sequelae of Stevens-Johnson Syndrome in Children: Long-term Impact of Appropriate Therapy on Natural History of Disease.
    Am J Ophthalmol 2018 Feb 5. Epub 2018 Feb 5.
    Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad-500034, India; Prof. Brien Holden Eye Research Center, Champalimaud Translational Centre for Eye Research, L V Prasad Eye Institute, Hyderabad-500034, India. Electronic address:
    Purpose: To describe the long-term ocular and visual morbidity in children with chronic sequelae of Stevens-Johnson Syndrome (SJS) and visual outcomes of various management strategies.

    Design: Retrospective comparative case series.

    Methods: This study included 568 eyes of 284 children with SJS who presented between 1990 and 2015. Read More

    Successful drug desensitization in patients with delayed-type allergic reactions to anti-tuberculosis drugs.
    Int J Infect Dis 2018 Feb 2;68:61-68. Epub 2018 Feb 2.
    Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand.
    Objective: To evaluate the outcomes of anti-tuberculosis drug desensitization.

    Methods: This was a retrospective study. Inclusion criteria were as follows: age >18years, documented tuberculosis infection, a previous cutaneous allergic reaction to anti-tuberculosis drugs, and having undergone drug desensitization between January 2003 and March 2014. Read More

    Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions.
    J Clin Invest 2018 Mar 5;128(3):985-996. Epub 2018 Feb 5.
    Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital (CGMH), Linkou, Taipei and Keelung, Taiwan.
    Background: Cytotoxic T lymphocyte-mediated (CTL-mediated) severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are rare but life-threatening adverse reactions commonly induced by drugs. Although high levels of CTL-associated cytokines, chemokines, or cytotoxic proteins, including TNF-α and granulysin, were observed in SJS-TEN patients in recent studies, the optimal treatment for these diseases remains controversial. We aimed to evaluate the efficacy, safety, and therapeutic mechanism of a TNF-α antagonist in CTL-mediated SCARs. Read More

    Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.
    Clin Pharmacol Ther 2018 Apr 2;103(4):574-581. Epub 2018 Feb 2.
    Department of Pharmacology, University of Liverpool, Liverpool, UK.
    The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes. Read More

    Survey of Nonprescription Medication and Antibiotic Use in Patients with Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, and Overlap Syndrome.
    Antibiotics (Basel) 2018 Feb 1;7(1). Epub 2018 Feb 1.
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
    Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and overlap syndrome (SJS-TEN) are rare, serious skin and mucosa break-down conditions frequently associated with antibiotic use. The role of nonprescription medications alone, or in combination with antibiotics in triggering SJS/TEN, is largely unknown. This study summarized data collected from patient surveys about nonprescription and antibiotic use prior to a SJS/TEN diagnosis. Read More

    Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database.
    Clin Transl Allergy 2018 22;8. Epub 2018 Jan 22.
    1Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
    Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrative database, focusing on demographic and clinical characteristics, and in the most frequently implicated drug classes.

    Methods: We analysed all drug-related hospitalisations with associated diagnosis of SJS/TEN or EM in Portuguese hospitals between 2009 and 2014. Read More

    Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese.
    Front Pharmacol 2017 17;8:923. Epub 2018 Jan 17.
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
    Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions. Evidence is growing that epigenetic variation, particularly DNA methylation, is associated with autoimmune diseases. However, the potential role of aberrant DNA methylation in allopurinol-SCARs is largely unknown. Read More

    Staphylococcal scalded skin syndrome in a 4-year-old child: a case report.
    J Med Case Rep 2018 Jan 29;12(1):20. Epub 2018 Jan 29.
    Department of Surgery, Burns unit, Rode Kruis Hospital, Beverwijk, Vondellaan 13, 1942LE, Beverwijk, The Netherlands.
    Background: Staphylococcal scalded skin syndrome is an exfoliating skin disease which primarily affects children. Differential diagnosis includes toxic epidermal necrolysis, staphylococcal scalded skin syndrome, epidermolysis bullosa, and Stevens-Johnson syndrome. Staphylococcal scalded skin syndrome primarily affects children and can cause serious morbidity. Read More

    Limbal Stem Cell Deficiency - Demography And Underlying Causes.
    Am J Ophthalmol 2018 Jan 26. Epub 2018 Jan 26.
    Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, India. Electronic address:
    Purpose: To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD DESIGN: Retrospective, multi-center case series SETTING: Two large tertiary care ophthalmology hospitals SUBJECTS: Patients with a diagnosis of LSCD presenting from January 1, 2005 to December 31, 2014 METHODS: Records of patients with a clinical diagnosis of LSCD were reviewed. Demographic details and clinical features at presentation, as well as the underlying cause of LSCD (if identified) were noted. Descriptive statistical analysis and chart preparation were done. Read More

    Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis.
    J Pharm Pharm Sci 2018 ;21(1):1-18
    Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand. Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
    Purpose: To systematically review and quantitatively synthesize associations between HLA genotypes and oxcarbazepine-induced cutaneous adverse drug reactions (OXC-cADRs), including Stevens-Johnson syndrome (SJS) and maculopapular rash.

    Methods: Studies investigating associations between HLA genotypes and OXC-cADRs were systematically searched irrespective of language, in PubMed, HuGENet (Human Genome Epidemiology Network), and the Cochrane Library from their inception until January, 2017. Inclusion criteria were studies investigating associations between HLA genotypes and OXC-cADRs that reported sufficient data for calculating the frequency of HLA genotype carriers among cases and controls. Read More

    Cyclosporine for Epidermal Necrolysis: Absence of Beneficial Effect in a Retrospective Cohort of 174 Patients-Exposed/Unexposed and Propensity Score-Matched Analyses.
    J Invest Dermatol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Dermatology, Hôpital Henri Mondor, Assistance Publique Hôpitaux de Paris, Créteil, France; Equipe d'accueil EpiDermE 7379, Université Paris Est Créteil, Créteil, France. Electronic address:
    Cyclosporine has shown promising results for mortality in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. However, available studies included only a small number of patients and did not include a validated and homogenous control group. We present the results from a retrospective monocentric study including 174 patients with Stevens-Johnson syndrome/toxic epidermal necrolysis during 2005-2016. Read More

    [Adverse cutaneous reactions to drugs].
    Rev Med Inst Mex Seguro Soc 2018 Jan-Feb;56(1):64-70
    Departamento de Dermatología, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Ciudad de México, México
    Adverse cutaneous reactions to drugs are any undesirable change in the structure or function of the skin. These are among the adverse side effects to common drugs. The most commonly implicated drugs are antibiotics and anticonvulsants. Read More

    Downregulation of interferon-γ-induced protein 10 in the tears of patients with Stevens-Johnson syndrome with severe ocular complications in the chronic stage.
    BMJ Open Ophthalmol 2017 7;1(1):e000073. Epub 2017 Aug 7.
    Departments of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Objectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute inflammatory vesiculobullous reactions of the skin and mucosa such as the ocular surface, oral cavity and genitals. Severe ocular complications (SOC) arise in some patients with SJS/TEN diagnosed by dermatologists. To investigate the pathophysiology of ocular surface inflammation in SJS/TEN with SOC in the chronic stage, we examined cytokines in the tears of patients with ocular surface diseases and healthy controls. Read More

    Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population.
    Eur Ann Allergy Clin Immunol 2018 Jan;50(1):36-41
    Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey.
    Summary: Many studies have shown associations between HLAB*15:02, HLA-A*31:01 and carbamazepine (CBZ)-induced delayed cutaneous hypersensitivity reactions. The aim of this study is to evaluate a possible association between delayed cutaneous reactions to antiepileptic drugs (AEDs) and certain HLA-A and HLA-B alleles in the Turkish population.The study consisted of 3 groups: Group I (reactive group) included the patients who had documented delayed cutaneous reactions to any antiepileptic drug. Read More

    Vitreoretinal Complications and Outcomes in 92 Eyes Undergoing Surgery for Modified Osteo-Odonto-Keratoprosthesis: A 10-Year Review.
    Ophthalmology 2018 Jan 13. Epub 2018 Jan 13.
    CJ Shah Cornea Services and Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Chennai, India.
    Purpose: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery.

    Design: Retrospective case series.

    Participants: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. Read More

    Toxic epidermal necrolysis: a paradigm of critical illness.
    Rev Bras Ter Intensiva 2017 Oct-Dec;29(4):499-508
    Instituto de Investigación Sanitaria del Hospital Universitario de Getafe - Madrid, Spain.
    Toxic epidermal necrolysis is an adverse immunological skin reaction secondary in most cases to the administration of a drug. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and multiform exudative erythema are part of the same disease spectrum. The mortality rate from toxic epidermal necrolysis is approximately 30%. Read More

    First case of Stevens-Johnson syndrome after rabies vaccination.
    Br J Clin Pharmacol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Pharmacy, Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
    We describe the first case of Stevens-Johnson syndrome (SJS) occurring 8 days after the first dose of a three-dose rabies vaccination series. She had no history of vaccine-related rash or other adverse drug reactions, nor had she received any other drug therapy. The temporal relationship between the development of SJS and the vaccination suggests that the rabies vaccination probably was the causal agent. Read More

    HLA Association with Drug-Induced Adverse Reactions.
    J Immunol Res 2017 23;2017:3186328. Epub 2017 Nov 23.
    Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan.
    Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. Read More

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