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    5944 results match your criteria Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

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    Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?
    Acta Dermatovenerol Croat 2018 Apr;26(1):61-63
    Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;
    Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

    A multivariate genetic analysis confirms rs5010528 in the human leucocyte antigen-C locus as a significant contributor to Stevens-Johnson syndrome/toxic epidermal necrolysis susceptibility in a Mozambique HIV population treated with nevirapine.
    J Antimicrob Chemother 2018 May 11. Epub 2018 May 11.
    Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
    Objectives: Nevirapine is used in developing countries for the treatment of HIV infection, but its use is associated with rare serious adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Recently, an association between rs5010528 in the human leucocyte antigen (HLA)-C locus and SJS/TEN susceptibility has been described in sub-Saharan populations. Our aim was to verify this association in a population of nevirapine-treated patients from Mozambique. Read More

    Management of Severe Cicatricial Entropion With Labial Mucous Membrane Graft in Cicatricial Ocular Surface Disorders.
    J Craniofac Surg 2018 May 14. Epub 2018 May 14.
    Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego School of Medicine.
    The management of cicatricial entropion represents a therapeutic challenge especially when the underlying causes are progressive cicatricial diseases that affect the ocular surface. The authors aimed to report long-term efficacy of labial mucous membrane graft to manage severe cicatricial entropion of the upper eyelid. This study is a retrospective chart review of patients who underwent tarsotomy associated with labial mucous membrane graft to treat severe cicatricial entropion of the upper eyelid. Read More

    Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis: a multicenter retrospective study of 377 adult patients from the United States.
    J Invest Dermatol 2018 May 11. Epub 2018 May 11.
    Departments of Dermatology and Medicine, University of Pennsylvania, Philadelphia, PA.
    Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 academic medical centers in the United States. 377 adult patients with SJS/TEN between 1/1/2000 and 6/1/2015 were entered, including 69. Read More

    Stevens-Johnson Syndrome associated with methotrexate treatment for acute lymphoblastic leukemia: a case report.
    Arch Argent Pediatr 2018 06;116(3):e459-e462
    Ege University Faculty of Medicine, Department of Pediatrics, Division of Hematology, İzmir, Turkey.
    Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare mucocutaneous diseases which are associated with a prolonged course and potentially lethal outcome. They are mostly drug induced and mortality rates are very high. Although mostly skin is involved, multiple organ systems such as cardiovascular, pulmonary, gastrointestinal, and urinary systems may be affected. Read More

    [Drug reaction with eosinophilia and systemic symptoms due to carbamazepine. Pediatric case].
    Arch Argent Pediatr 2018 06;116(3):e433-e436
    Instituto Roosevelt, Universidad del Rosario, Andes y Salcana. Bogotá, Colombia.
    Severe skin reactions include Stevens-Johnson Syndrome, toxic epidermal necrolysis and Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, which are uncommon in the pediatric population (incidence 1/1000- 10 000 children), but they have bad prognosis. Drug-sensitive Syndrome with eosinophilia and systemic symptoms consists in rash, hematological abnormalities, lymphadenopathy and organ involvement. We report the case of a 12-year-old male patient who developed this pathology after initiating anticonvulsant therapy with carbamazepine. Read More

    Bullous Fixed Drug Eruption Following Ibuprofen Ingestion.
    J Res Pharm Pract 2018 Jan-Mar;7(1):51-56
    Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Fixed drug eruption (FDE) is a drug reaction involving skin and less commonly mucosal membranes. The common manifestation is localized well-demarcated patches or plaques appeared following receiving of a culprit drug. When re-exposure occurs, the rashes will appear at areas involved in previous episodes. Read More

    Chemotherapy patient with Stevens-Johnson Syndrome presents to the Emergency Department: A case report.
    Am J Emerg Med 2018 Apr 11. Epub 2018 Apr 11.
    Emergency Department, Southside Hospital - Northwell Health, 301 E Main St, Bay Shore, NY 11706, United States.
    Background: Stevens-Johnson syndrome (SJS) is part of a continuum of severe mucocutaneous reactions, commonly thought to be triggered by certain medications. The syndrome itself is characterized by diffuse necrosis and detachment of the epidermis.

    Case Report: This case report discusses a patient who presented to the Emergency Department with signs and symptoms of Stevens-Johnson syndrome four days after chemotherapy administration of ribociclib (Kisqali®). Read More

    Stevens-Johnson Syndrome After Armodafinil Use.
    J Clin Sleep Med 2018 May 15;14(5):885-887. Epub 2018 May 15.
    Ohio Sleep Medicine Institute, Dublin, Ohio.
    Abstract: We present the case of a 21-year-old woman in whom Stevens-Johnson syndrome (SJS) developed after initiation of armodafinil. Although this rare and life-threatening reaction is listed on armodafinil's label, no cases have been reported in the literature. This case, in addition to an update of the drug's label after post-marketing research, both support the link between armodafinil and SJS. Read More

    Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities.
    Open Access Maced J Med Sci 2018 Apr 28;6(4):730-738. Epub 2018 Mar 28.
    All Saints University, School of Medicine, Roseau, Dominica.
    Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Read More

    Response: The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity.
    Epilepsia 2018 May;59(5):1084-1085
    Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

    [Acute life-threatening drug reactions of the skin].
    Hautarzt 2018 May 2. Epub 2018 May 2.
    Dokumentationszentrum schwerer Hautreaktionen (dZh), Universitätsklinik für Dermatologie und Venerologie, Hauptstr. 7, 79104, Freiburg, Deutschland.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acutely occurring, unpredictable, often life-threatening reactions that are a huge challenge in clinical practice. They are characterized by extensive blistering of skin and mucosa and are considered as one disease entity of different severity. Thus, they are summarized as SJS/TEN or EN (for epidermal or epithelial necrolysis). Read More

    Diverse expression of TNF-α and CCL27 in serum and blister of Stevens-Johnson syndrome/toxic epidermal necrolysis.
    Clin Transl Allergy 2018 20;8:12. Epub 2018 Apr 20.
    1Department of Dermatology, First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou, 510080 China.
    Background: The pathogenesis of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is not fully understood. Our previous study reported that chemokine CCL27 was overexpressed in serum of SJS/TEN patients. The objective of this study was to investigate the levels of CCL27 and TNF-α in serum and blister fluid from patients with SJS/TEN during the acute stage or resolution phase. Read More

    Association between HLA-B*44:03-HLA-C*07:01 haplotype and cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Thailand.
    Br J Ophthalmol 2018 Apr 29. Epub 2018 Apr 29.
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Background: Polymorphisms in human leucocyte antigen (HLA) class I genes have been found to be associated with cold medicine (CM)-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications (SOC). Because ethnic differences in genetic predisposition to SJS/TEN among different populations have been proposed, we focused on Thai patients and investigated the association between HLA class I genotypes and CM-SJS/TEN with SOC.

    Methods: This multicentre case-control study was conducted between September 2014 and August 2017. Read More

    A 10-years retrospective study on Severe Cutaneous Adverse Reactions (SCARs) in a tertiary hospital in Penang, Malaysia.
    Med J Malaysia 2018 Apr;73(2):73-77
    Hospital Pulau Pinang, Dermatology Department, Jalan Residensi, Georgetown, Penang, Malaysia.
    Introduction: Severe cutaneous adverse drug reactions (SCARs) are not uncommon and potentially lifethreatening. Our objective is to study the patient characteristics, the pattern of implicated drugs and treatment outcome among patients with SCARs.

    Methods: A 10-year retrospective analysis of SCARs cases in Penang General Hospital was carried out from January 2006 to December 2015. Read More

    Management of Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis: Looking Beyond Guidelines!
    Indian J Dermatol 2018 Mar-Apr;63(2):117-124
    Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions, which are mainly caused by drugs; and these are usually associated with high degree of morbidity and mortality. Recently, two detailed guidelines were published on the management of SJS/TEN, Indian guidelines and UK guidelines. Still, there is no consensus on the management of SJS/TEN. Read More

    The HLA-B*15:02 polymorphism and Tegretol-induced serious cutaneous reactions in epilepsy: An updated systematic review and meta-analysis.
    Rev Neurol (Paris) 2018 May;174(5):278-291
    Tunis El Manar University, Faculty of Medicine Tunis, Department of Genetic, 15 Jebel Lakhdhar Street, La Rabta, 1007 Tunis, Tunisia.
    Tegretol [carbamazepine (CBZ)], an aromatic drug approved for epilepsy treatment, can induce adverse drug reactions (ADRs) after its administration. Several genetic studies of epilepsy have shown that genetic polymorphisms increase the risk of ADRs, and some interactions between CBZ and other treatments can also induce adverse effects. Thus, to avoid such interactions and to provide an overview of the genetic profiles involved in ADRs with CBZ, for the first time, a systematic review and meta-analysis focusing on epilepsy was performed, using Cochrane Library, Embase and PubMed databases to find studies published between January 1980 and October 2016. Read More

    Lamotrigine Rechallenge in Treatment-Resistant Bipolar Disorder.
    Prim Care Companion CNS Disord 2018 Mar 29;20(2). Epub 2018 Mar 29.
    Saga University, Department of Psychiatry, Nabeshima 5-1-1, Saga-city, Saga 849-8501, Japan.
    Background: Although lamotrigine may be useful for treating patients with treatment-resistant bipolar disorder, some lamotrigine-associated adverse effects, including mild to moderate skin rash, may prevent the continuation of treatment.

    Methods: We investigated lamotrigine rechallenge for the treatment of bipolar disorder. The present study was based on retrospective chart review of outpatients with bipolar disorder (DSM-5 criteria) who visited the hospital's psychiatric department between July 2011 and August 2017. Read More

    [Treatment of severe cutaneous adverse drug reactions].
    Ann Dermatol Venereol 2018 Apr 13. Epub 2018 Apr 13.
    Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; Centre de référence des dermatoses bulleuses toxiques et toxidermies graves (filière FIMARAD), hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France.

    Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Call for Optimum Patient Stratification and Theranostics via Pharmacogenomics.
    Annu Rev Genomics Hum Genet 2018 Apr 13. Epub 2018 Apr 13.
    South East Asian Pharmacogenomics Research Network (SEAPHARM).
    The Global Genomic Medicine Collaborative, a multinational coalition of genomic and policy experts working to implement genomics in clinical care, considers pharmacogenomics to be among the first areas in genomic medicine that can provide guidance in routine clinical practice, by linking genetic variation and drug response. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe life-threatening reactions to medications with a high incidence worldwide. Genomic screening prior to drug administration is a key opportunity and potential paradigm for using genomic medicine to reduce morbidity and mortality and ultimately eliminate one of the most devastating adverse drug reactions. Read More

    An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.
    J Immunol Res 2018 13;2018:6431694. Epub 2018 Feb 13.
    Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou, Keelung, Taiwan.
    Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Read More

    Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4 T-Cells from Hypersensitive Patients.
    Chem Res Toxicol 2018 May 16. Epub 2018 May 16.
    Instituto Politécnico Nacional , Unidad Profesional Interdisciplinaria de Biotecnología , Mexico City 07340 , México.
    Dysregulation in the expression of microRNAs (miRNAs), single-stranded RNAs which regulate gene expression, has been associated with diseases such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), although their cellular origin has not been explored. Thus, the focus of this work was to study expression patterns of reported miRNAs involved in T-cell activation following drug-specific stimulation in peripheral blood mononuclear cells (PBMCs) and drug-specific CD4 T-cell clones (TCC) from patients with different cutaneous manifestations of delayed-type drug hypersensitivity reactions. CD4 T-cells from hypersensitive patients were stimulated to proliferate, secreted cytokines (IFN-γ and IL-22), cytolytic molecules (Granzyme B) and up-regulate miRNAs 24 to 48 h after drug exposure. Read More

    A retrospective investigation of HLA-B*5801 in hyperuricemia patients in a Han population of China.
    Pharmacogenet Genomics 2018 May;28(5):117-124
    Functional Genomics Group, Genomic Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.
    Background: Hyperuricemia and gout have become increasingly prevalent in China. Allopurinol is an effective urate-lowering therapy, but it has severe side effects. HLA-B*5801 is highly associated with the allopurinol-induced toxic epidermal necrolysis and Stevens-Johnson syndrome. Read More

    Retrospective review of paediatric case reports of Stevens-Johnson syndrome and toxic epidermal necrolysis with lamotrigine from an international pharmacovigilance database.
    BMJ Paediatr Open 2017 4;1(1):e000039. Epub 2017 Aug 4.
    Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UK.
    Objectives: This study aims to characterise paediatric reports with lamotrigine (LTG) and Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN), and to explore whether potential risk factors can be identified.

    Design: This is a retrospective review of suspected adverse drug reaction (ADR) reports. Reported time from LTG start to SJS/TEN onset, indication for use and dose was explored. Read More

    CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment.
    Pharmgenomics Pers Med 2018 29;11:51-58. Epub 2018 Mar 29.
    Department of Neurology, Catholic University of Parana (PUCPR), Curitiba, Brazil.
    Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and status epilepticus, and effective in controlling focal seizures with and without tonic-clonic generalization and status epilepticus. The metabolization of PHT is carried out by two oxidative cytochrome P450 enzymes CYP2C9 and CYP2C19; 90% of this metabolization is done by CYP2C9 and the remaining 10% by CYP2C19. Genetic polymorphism of CYP2C9 may reduce the metabolism of PHT by 25-50% in patients with variants *2 and *3 compared to those with wild-type variant *1. Read More

    A meta-analysis of cyclosporine treatment for Stevens-Johnson syndrome/toxic epidermal necrolysis.
    J Inflamm Res 2018 28;11:135-142. Epub 2018 Mar 28.
    Department of Paediatrics, National University Hospital, National University Health System, Singapore.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are dermatologic emergencies with high morbidity and mortality risk. Cyclosporine, an immunomodulatory agent, is sometimes used off-label, and its role continues to be debated. This meta-analysis aimed to provide an update of current evidence and to clarify the role of cyclosporine in SJS/TEN treatment better. Read More

    Epidermal necrolysis French national diagnosis and care protocol (PNDS; protocole national de diagnostic et de soins).
    Orphanet J Rare Dis 2018 Apr 10;13(1):56. Epub 2018 Apr 10.
    Dermatology Department, AP-HP, Henri Mondor Hospital, 51 avenue du maréchal de Lattre de Tassigny, 94000, Créteil, France.
    Epidermal necrolysis (EN) encompasses Stevens-Johnson syndrome (SJS, < 10% of the skin affected), Lyell syndrome (toxic epidermal necrolysis, TEN, with ≥30% of the skin affected) and an overlap syndrome (10 to 29% of the skin affected). These rare diseases are caused, in 85% of cases, by pharmacological treatments, with symptoms occurring 4 to 28 days after treatment initiation. Mortality is 20 to 25% during the acute phase, and almost all patients display disabling sequelae (mostly ocular impairment and psychological distress). Read More

    Treatment of toxic epidermal necrolysis by a multidisciplinary team. A review of literature and treatment results.
    Burns 2018 Jun 4;44(4):807-815. Epub 2018 Apr 4.
    Department of Dermatology and Skin Science, University of British Columbia, Canada.
    Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are mucocutaneous hypersensitivity reactions, usually to drugs or their metabolites. TEN is the most severe involving greater than 30% of the total body surface area (TBSA). Management of these patients usually benefits from a large multidisciplinary team for both wound and medical management. Read More

    Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population.
    JAMA Neurol 2018 Apr 2. Epub 2018 Apr 2.
    RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
    Importance: Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes of cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 is reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, the clinical utility of HLA-A*31:01 has not been evaluated.

    Objective: To assess the use of HLA-A*31:01 genetic screening to identify Japanese individuals at risk of carbamazepine-induced cADRs. Read More

    and Oxcarbazepine-Induced DRESS in a Patient With Seizures and Complete Deletion.
    Pediatrics 2018 Apr;141(Suppl 5):S434-S438
    Clinical Pharmacogenomics Service,
    Oxcarbazepine is an antiepileptic drug (AED) commonly used as a first-line treatment option for focal epilepsy. Several AEDs, including carbamazepine, oxcarbazepine, and phenytoin are associated with various delayed-hypersensitivity reactions such as drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, or toxic epidermal necrolysis. The Food and Drug Administration-approved label for oxcarbazepine currently presents information regarding a pharmacogenomic association with the HLA antigen allele and hypersensitivity reactions in certain ancestry groups with a high incidence of this allele. Read More

    Histopathology of Cutaneous Inflammatory Disorders in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):115-149
    1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
    Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Read More

    Trichloroethylene Hypersensitivity Syndrome: Should Be Considered When Diagnosing DRESS Syndrome.
    J Korean Med Sci 2018 Apr 2;33(14):e106. Epub 2018 Apr 2.
    Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.
    Trichloroethylene (TCE) is an organic solvent that is used for degreasing and removing impurities from metal parts. However, this solvent's characteristics and hypersensitivity can produce clinical patterns and laboratory data that mimic drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. Thus, exposure confirmation is critical to making an accurate diagnosis. Read More

    The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.
    J Immunol Res 2018 11;2018:4320195. Epub 2018 Feb 11.
    Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
    Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. Read More

    Selected presentations of lip enlargement: clinical manifestation and differentiation.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):18-25. Epub 2018 Feb 20.
    Department of Oral Surgery, Poznan University of Medical Sciences, Poznan, Poland.
    Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. Read More

    Vancomycin-Induced Stevens-Johnson Syndrome in a Boy Under 2 Years Old: An Early Diagnosis by Granulysin Rapid Test.
    Front Pediatr 2018 13;6:26. Epub 2018 Mar 13.
    School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    Stevens-Johnson syndrome (SJS) is a life-threatening disease, which is mainly ascribed to drugs, such as sulfonamides and psychoepileptics. In this article, we present a pediatric case of vancomycin-induced SJS and an alternative diagnostic algorithm. The patient presented with multiple target-like rashes and vesicles throughout the whole body after receiving vancomycin. Read More

    A New Search Method Using Association Rule Mining for Drug-Drug Interaction Based on Spontaneous Report System.
    Front Pharmacol 2018 9;9:197. Epub 2018 Mar 9.
    Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
    Adverse events (AEs) can be caused not only by one drug but also by the interaction between two or more drugs. Therefore, clarifying whether an AE is due to a specific suspect drug or drug-drug interaction (DDI) is useful information for proper use of drugs. Whereas previous reports on the search for drug-induced AEs with signal detection using spontaneous reporting systems (SRSs) are numerous, reports on drug interactions are limited. Read More

    Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies.
    J Immunol Res 2018 17;2018:5376476. Epub 2018 Jan 17.
    Department of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, Taiwan.
    Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions (these are proposed mechanism, not definite). Differentiating SCARs from other more commonly seen reactions with a better outcome help prevent discontinuation of therapy and inappropriate use of systemic immunosuppressants for presumable allergic reactions, of which will affect the clinical outcome. Read More

    Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management.
    Curr Allergy Asthma Rep 2018 Mar 24;18(4):26. Epub 2018 Mar 24.
    Department of Rheumatology, Immunology and Allergology, University Hospital and University of Bern, Bern, Switzerland.
    Purpose Of Study: Immune-mediated adverse drug reactions occur commonly in clinical practice and include mild, self-limited cutaneous eruptions, IgE-mediated hypersensitivity, and severe cutaneous adverse drug reactions (SCAR). SCARs represent an uncommon but potentially life-threatening form of delayed T cell-mediated reaction. The spectrum of illness ranges from acute generalized exanthematous pustulosis (AGEP) to drug reaction with eosinophilia with systemic symptoms (DRESS), to the most severe form of illness, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis-like cutaneous presentation of chikungunya fever: A case series.
    Pediatr Dermatol 2018 May 24;35(3):392-396. Epub 2018 Mar 24.
    Department of Pediatrics, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
    Chikungunya fever is a benign, self-limiting, acute viral illness. An epidemic occurred in New Delhi, India, in August and September 2016. We observed many cases with atypical cutaneous features mimicking Stevens-Johnson syndrome and toxic epidermal necrolysis during this epidemic, especially in infants and children. Read More

    The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison to the USA FDA Label.
    Clin Pharmacol Ther 2018 Mar 23. Epub 2018 Mar 23.
    Chang Gung Memorial Hospital, Linkou, Taiwan.
    Specific ethnic genetic backgrounds associated with risk of Stevens-Johnson syndrome/toxic epidermal necrolysis(SJS/TEN) especially in Asians. However, there have been no large cohort, multiple-country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998-2017. Read More

    [Severe skin reactions due to new medications].
    Hautarzt 2018 Apr;69(4):278-289
    Dokumentationszentrum schwerer Hautreaktionen (dZh), Universitätsklinik für Dermatologie und Venerologie, Hauptstr. 7, 79104, Freiburg, Deutschland.
    Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and a specific form of hypersensitivity syndrome which is nowadays called "drug reaction with eosinophilia and systemic symptoms" (DRESS) are severe, mainly drug-induced skin reactions. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as drug reaction, in total only about three quarters of the cases are actually caused by drugs. Read More

    Hemophagocytic lymphohistiocytosis in an infant with multiple triggers!!
    Asian J Transfus Sci 2018 Jan-Jun;12(1):85-88
    Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, New Delhi, India.
    Hemophagocytic lymphohistiocytosis (HLH) is a disorder of immune dysregulation secondary to a massive unregulated cytokine storm and its downstream consequences. HLH is being increasingly recognized as a cause of pyrexia of unknown origin, unexplained cytopenias, and hepatic dysfunction. However, this potentially treatable condition is often missed due to lack of suspicion, variable, and nonspecific presentations, inability to fulfil all the diagnostic criteria and availability of diagnostic tests in resource limited settings. Read More

    Clinical and histologic features of Mycoplasma pneumoniae-related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes.
    J Am Acad Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Dermatology Department, Assistance Publique Hôpitaux de Paris (AP-HP), Henri Mondor Hospital, Créteil, France; Epidémiologie en Dermatologie et Evaluation des Thérapeutiques, Université Paris-Est Créteil (UPEC) Val de Marne, Créteil, France; Referral Center for Toxic Bullous Diseases, AP-HP, Henri Mondor Hospital, Créteil, France; UPEC, Créteil, France.
    Background: Mycoplasma pneumoniae infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of M pneumoniae-related EM have been poorly described in the literature.

    Objective: To highlight differences between M pneumoniae EM and non-M pneumoniae EM. Read More

    Selective Use of Cyclosporine for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis May Exclude Patients with Poor Prognostic Factors.
    J Invest Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

    Toxic Epidermal Necrolysis: A Dermatologic Emergency and the Role of the Oral and Maxillofacial Surgeon.
    J Oral Maxillofac Surg 2018 Feb 23. Epub 2018 Feb 23.
    Associate Program Director, Department of Oral and Maxillofacial Surgery, Nassau University Medical Center, East Meadow, NY.
    Toxic epidermal necrolysis (TEN) is a rare and severe mucocutaneous disorder characterized by mucosal and epidermal necrosis and sloughing. This potentially life-threatening condition, together with the less severe Stevens-Johnson syndrome, is commonly caused by an immunologic reaction to medications and can lead to many long-term complications. The disorder initially presents with fever, malaise, and painful mucosal ulcerations (most commonly oral) but progresses to widespread cutaneous lesions. Read More

    Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients.
    J Immunol Res 2018 10;2018:2780272. Epub 2018 Jan 10.
    Department of Community Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    The ∗ allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. Read More

    Association Between HLA-B*1301 and Dapsone-Induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-analysis.
    JAMA Dermatol 2018 Apr;154(4):441-446
    Center of Excellence for Environmental Health and Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
    Importance: Dapsone-induced hypersensitivity syndrome (DHS) is a life-threatening adverse drug reaction. Based on available epidemiologic studies, HLA genotypes may play an important role in DHS.

    Objective: To assess the association between HLA-B*1301 and dapsone-induced cutaneous adverse drug reactions (cADRs). Read More

    Anterior segment optical coherence tomography findings in type I Boston keratoprosthesis.
    Arq Bras Oftalmol 2018 Jan-Feb;81(1):42-46
    Department of Ophthalmology and Visual Sciences, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Purpose: To report the results of high-resolution anterior segment optical coherence tomography of patients implanted with a type 1 Boston keratoprosthesis (KPro).

    Methods: The retrospective study cohort included 11 eyes of 11 patients (average age, 58.4 years; range, 34-83 years). Read More

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