6,136 results match your criteria Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis


Adverse Drug Reaction Onsets in Uganda's VigiBase: Delayed International Visibility, Data Quality and Illustrative Signal Detection Analyses.

Pharmaceut Med 2018 17;32(6):413-427. Epub 2018 Nov 17.

3MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Introduction: Developing countries can improve their pharmacovigilance systems by analysing their own medication safety data.

Objective: The aims of this study were to characterize Uganda's reported adverse drug reaction (ADR) onsets in 2012-2015 that were registered on VigiBase by 31 December 2017, to document delays in international visibility and the influence of covariates on this delay from ADR onsets in 2013 + 2014, to examine data quality, and to illustrate analytical approaches for safety data, particularly for patients receiving antiretroviral therapy (ART).

Methods: International delay was defined as elapsed time from complete ADR onset date to entry date on VigiBase, with covariates examined using Cox proportional hazards regression. Read More

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November 2018
1 Read

[AN UPDATE ON DIAGNOSIS AND MANAGEMENT OF DRUG ALLERGY].

Authors:
Michiko Aihara

Arerugi 2018 ;67(10):1399-1404

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine.

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January 2018

Stevens-Johnson syndrome on treatment with sulfasalazine for Crohn's disease: Need for a multidisciplinary approach.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology Section, DBiMis, University of Palermo, Palermo, Italy.

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December 2018

An Interesting Case of Carbamazepine-Induced Stevens-Johnson Syndrome.

Drug Saf Case Rep 2018 Dec 10;6(1). Epub 2018 Dec 10.

Division of Psychiatry, Harare Central Hospital, PO Box ST 14, Southerton, Harare, Zimbabwe.

A 29-year-old Black female patient was admitted to a psychiatric ward with symptoms of major depressive disorder with psychosis. The patient was started on amitriptyline 50 mg/day and haloperidol 10 mg/day. On day 4 post-admission, the preferred first-line antidepressant, fluoxetine, became available and the patient was switched from amitriptyline to fluoxetine 20 mg/day. Read More

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December 2018
1 Read

The presence of HLA-B75, DR13 homozygosity or DR14 additionally increases the risk of allopurinol induced severe cutaneous adverse reactions in HLA-B*58:01 carriers.

J Allergy Clin Immunol Pract 2018 Dec 6. Epub 2018 Dec 6.

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: Although HLA-B*58:01 is a well-known risk factor for the development of allopurinol-induced severe cutaneous adverse reactions (SCARs), most of the HLA-B*58:01 carriers do not suffer from SCARs despite a long-term use of allopurinol. This suggests that there are other risk factors that determine the fate of HLA-B*58:01 carriers.

Objective: The aim of this study was to investigate the additional genetic factors that increases the risk of allopurinol-induced SCARs in HLA-B*58:01 carriers. Read More

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December 2018

Stevens-Johnson syndrome-like reaction without mucosal lesions associated with cyclophosphamide.

Authors:
Yang Lo Chun-An Yao

Indian J Dermatol Venereol Leprol 2018 Nov 30. Epub 2018 Nov 30.

Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.

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November 2018

Novel complication of Flakka: Stevens-Johnson syndrome/Toxic epidermal necrolysis overlap.

Am J Emerg Med 2018 Nov 24. Epub 2018 Nov 24.

Department of Emergency Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.

Flakka, as the newest member of the synthetic cathinone group, is a substance with serious cardiovascular, neurological, psychiatric, infectious effects and addictive potential. There are only a few case reports and laboratory studies in the literature and there is no dermatological side effects reported yet. We present the first Stevens-Johnson syndrome/Toxic epidermal necrolysis (SJS/TEN) overlap case after Flakka use. Read More

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November 2018

Drug-induced liver injury with skin reactions: Drugs and host risk factors, clinical phenotypes and prognosis.

Liver Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, St. John's Medical College Hospital, Bangalore, India.

While dermatologic manifestations of adverse drug reactions are frequent, drug-induced liver injury is rare. Numerous drugs are implicated in either Drug-Induced Liver Injury or Drug-Induced Skin Injury. However, concomitant Drug-Induced Liver Injury and Drug-Induced Skin Injury are uncommon, not well characterized and appear to be caused by a limited number of drugs. Read More

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December 2018
3 Reads

Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.

Lancet 2018 Nov 30. Epub 2018 Nov 30.

The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, National Institute of Health Research Biomedical Research Centre, London, UK.

Background: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. Read More

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November 2018
3 Reads

Oral isotretinoin for acne.

Cochrane Database Syst Rev 2018 Nov 24;11:CD009435. Epub 2018 Nov 24.

Emergency Medicine and Evidence Based Medicine, Universidade Federal de São Paulo, Rua Napoleão de Barros, 865, São Paulo, Sao Paulo, Brazil, 04024-002.

Background: Acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit associated with socialisation and mental health problems, may affect more than 80% of teenagers. Isotretinoin is the only drug that targets all primary causal factors of acne; however, it may cause adverse effects.

Objectives: To assess efficacy and safety of oral isotretinoin for acne vulgaris. Read More

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November 2018

Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.

Authors:
Mayumi Ueta

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES183-DES191

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute inflammatory vesiculobullous reactions of the mucosa of the ocular surface, oral cavity, and genitals, and of the skin. Severe ocular complications (SOC) are present in about half of SJS/TEN patients diagnosed by dermatologists. We review our group's findings on the genetic predisposition for and the etiology of SJS/TEN with SOC. Read More

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November 2018
1 Read

Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage.

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES80-DES86

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Stevens-Johnson syndrome (SJS), and its more severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of the skin and mucous membranes. After the acute-stage damage subsides, serious visual impairment and severe dry eye remains as ocular sequelae. At the acute stage, ocular complications occur in 77% of SJS/TEN patients. Read More

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November 2018
6 Reads

Temporal trends and patterns in carbamazepine use, related severe cutaneous adverse reactions, and HLA-B*15:02 screening: A nationwide study.

Epilepsia 2018 Dec 26;59(12):2325-2339. Epub 2018 Nov 26.

Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Objective: After discovering the association between the HLA-B*15:02 allele and carbamazepine-related severe cutaneous adverse reactions (SCARs), particularly in Southeastern Asian populations, clinical strategies to prevent carbamazepine-related SCARs have changed. We aimed to investigate 10-year trends in carbamazepine use and carbamazepine-related SCARs and to examine the patterns and determinants of HLA-B*15:02 screening in Taiwan.

Methods: A nationwide study was performed using Taiwan's National Health Insurance Research Database. Read More

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December 2018
1 Read

Treatment of oral manifestations of toxic epidermal necrolysis with low-level laser therapy in a pediatric patient.

Pediatr Dermatol 2018 Nov 26. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

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November 2018
3 Reads

Major Histocompatibility Complex and Psoriasis.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S79-S80

The Institute of Dermatology and Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, China. Electronic address:

Major histocompatibility complex (MHC), also known as human leukocyte antigen (HLA) in humans, is one of the most genetically diverse regions in the genome of various species. The human MHC contains about 400 genes in a ∼7.6-Mb span located on the short arm of the chromosomal region 6p21. Read More

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December 2018
6 Reads

Long-term outcome of using Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) as a drug delivery system for bevacizumab in the treatment of corneal neovascularization.

Ocul Surf 2018 Nov 20. Epub 2018 Nov 20.

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.

Purpose: To report the long-term outcome of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) for delivery of bevacizumab in the treatment of corneal neovascularization (KNV).

Methods: Retrospective, non-comparative, interventional case series of 13 sequential patients treated for KNV at the BostonSight between 2006 and 2017. In all cases, PROSE treatment was initiated for management of ocular surface disease and patients wore PROSE consistently on a daily wear basis prior to bevacizumab treatment. Read More

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November 2018
8 Reads

Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Jpn J Clin Oncol 2018 Nov 17. Epub 2018 Nov 17.

Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Japan.

Background: Cutaneous adverse reactions are frequently induced by mogamulizumab. Cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and severe photosensitivity related to mogamulizumab have been reported. This study investigated whether severe radiation-induced dermatitis occurred in patients undergoing radiotherapy after the administration of mogamulizumab for adult T-cell leukaemia/lymphoma. Read More

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November 2018
5 Reads

Gastro-intestinal involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis : a retrospective case series.

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor - Albert Chenevier, Assistance Publique - Hôpitaux de Paris (AP-HP), Créteil, France.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by extensive skin and mucosal membrane detachment together with specific visceral involvement. While respiratory tract and ear, nose, and throat mucosal lesions have been comprehensively described, gastro-intestinal (GI) involvement, although previously reported, has been less investigated. Clinical manifestations are non-specific, including ileus, emesis, diarrhea, hematemesis, melena/rectal bleeding, abdominal pain, or dysphagia. Read More

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November 2018
2 Reads

Propranolol eye drops in patients with corneal neovascularization.

Medicine (Baltimore) 2018 Nov;97(45):e13002

Pediatric Ophthalmology Unit, Niguarda Ca' Granda Metropolitan Hospital, Milan, Italy.

Rationale: Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens-Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe ocular neo-vascularization treated with different degrees of success, with propranolol eye drops. Read More

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November 2018
5 Reads

Stevens-Johnson syndrome.

Intern Emerg Med 2018 Nov 8. Epub 2018 Nov 8.

Department of ENT and Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pillaiyarkuppam, Pondicherry, 607402, India.

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November 2018
4 Reads

Methotrexate-Induced Toxic Epidermal Necrolysis: A Rare Case Report and Review of Literature.

Indian J Crit Care Med 2018 Oct;22(10):740-742

Department of Medical Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Acute lymphoblastic leukemia (ALL) is the most common malignancy in pediatric patients, and it is characterized by the presence of malignant lymphoblasts within the bone marrow and peripheral blood. The treatment of ALL involves induction, consolidation, reinduction, and maintenance therapy. Consolidation therapy in ALL-Berlin-Frankfurt-Münster 90 protocol involves the use of high-dose methotrexate (HDMTX, 5 g/m) over 24 h as continuous infusion. Read More

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October 2018
5 Reads

Erratum: Successful Treatment of Stevens-Johnson Syndrome with Cyclosporine and Corticosteroid: Correction.

Authors:

Can J Hosp Pharm 2018 Sep-Oct;71(5):292. Epub 2018 Oct 31.

[This corrects the article on p. 272 in vol. 71, PMID: 30186001. Read More

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October 2018
1 Read

Idiopathic Stevens-Johnson syndrome and toxic epidermal necrolysis: prevalence and patients characteristics.

J Am Acad Dermatol 2018 Nov 2. Epub 2018 Nov 2.

EA 7379 EpiDermE, Université Paris Est Créteil, France; Department of Dermatology, Hôpital Henri-Mondor, AP-HP, Créteil, France.

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November 2018
1 Read

Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System.

Epilepsia 2018 Dec 5;59(12):2318-2324. Epub 2018 Nov 5.

University of Rhode Island College of Pharmacy, Kingston, Rhode Island.

Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and potentially fatal adverse skin reactions that are most commonly triggered by certain medications. One class of medications that has been highly associated with SJS/TEN reactions is antiepileptic drugs (AEDs). We sought to quantify the risk of SJS/TEN associated with AEDs as a class, as well as individual AEDs, in the United States. Read More

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December 2018
2 Reads

Long-term effect of corneoscleral contact lenses on refractory ocular surface diseases.

Cont Lens Anterior Eye 2018 Oct 30. Epub 2018 Oct 30.

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Electronic address:

Purpose: To report the therapeutic effect of corneoscleral contact lenses (CLs) with a diameter of 14.0 mm on the refractory ocular surface diseases.

Methods: Medical records of 13 eyes (of nine patients) attempted for fitting with corneoscleral CLs for the management of the severe refractory ocular surface diseases were retrospectively reviewed including Stevens-Johnson syndrome (SJS; eight eyes) and chronic ocular graft-versus-host disease (GVHD; five eyes). Read More

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October 2018
4 Reads

Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships.

J Chem Inf Model 2018 Nov 9;58(11):2203-2213. Epub 2018 Nov 9.

Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , North Carolina 27599 , United States.

Quantitative structure-activity relationships (QSAR) models are often seen as a "black box" because they are considered difficult to interpret. Meanwhile, qualitative approaches, e.g. Read More

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November 2018
17 Reads

Generalized bullous fixed-drug eruption secondary to the influenza vaccine.

JAAD Case Rep 2018 Oct 12;4(9):953-955. Epub 2018 Oct 12.

University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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October 2018
1 Read

Corneal limbal stem cell deficiency in children with Stevens-Johnson syndrome.

Am J Ophthalmol 2018 Oct 19. Epub 2018 Oct 19.

Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Purpose: To determine the incidence of corneal limbal stem cell deficiency (LSCD) as chronic ocular sequelae in children with Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN) and analyze the factors associated with LSCD development.

Design: Retrospective case series.

Methods: Medical records were reviewed of pediatric patients who had been admitted to Seoul National University Hospital with SJS/TEN and diagnosed as having acute ocular involvement. Read More

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October 2018
10 Reads

Successful dabrafenib transition after vemurafenib-induced toxic epidermal necrolysis in a patient with metastatic melanoma.

JAAD Case Rep 2018 Oct 10;4(9):930-933. Epub 2018 Oct 10.

Southwest Skin Specialists, Phoenix, Arizona.

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October 2018
5 Reads

Topical Treatment of Persistent Epithelial Defects with a Matrix Regenerating Agent.

J Ocul Pharmacol Ther 2018 Nov 12;34(9):621-627. Epub 2018 Oct 12.

Department of Ophthalmology, School of Medicine, Marmara University , Istanbul, Turkey .

Purpose: The aim of the study was to assess the efficacy of a topical regenerating agent (RGTA) for management of persistent epithelial defects (PEDs) resistant to conventional therapy.

Methods: Twenty-one patients (23 eyes) with PEDs despite the use of conventional therapy for lagophthalmos (n = 4), neurotrophic ulcer (n = 9), chemical burn (n = 3), Stevens-Johnson syndrome (n = 1), atopic keratoconjunctivitis (n = 1), severe dry eye (n = 2), peripheral ulcerative keratitis (n = 1), fungal keratitis (n = 1), and bacterial keratitis (n = 1) were enrolled in the study. Patients were treated with RGTA (Cacicol; Thea, Paris, France) instilled at a dosage of one drop on alternate days. Read More

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November 2018
17 Reads

Drug Allergy.

Pediatr Ann 2018 Oct;47(10):e419-e425

Drug allergy is commonly encountered in clinical practice. It is an immunological response to a pharmaceutical agent. The clinical presentation can vary from mild cutaneous reactions to life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Read More

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October 2018
8 Reads

Non-nucleoside reverse transcriptase inhibitors (NNRTIs)-induced Stevens-Johnson syndrome and gynecomastia in an HIV-infected child: A case report.

Ann Dermatol Venereol 2018 Dec 6;145(12):773-776. Epub 2018 Oct 6.

Service de dermatologie et IST, CHU Sylvanus Olympio, BP 30785, Lomé, Togo.

Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs often used in the first-line treatment regimen of HIV1 infection worldwide. We report a case of successive gynecomastia and Stevens-Johnson syndrome (SJS) respectively induced by efavirenz and nevirapine in a single patient.

Case Report: A 16-year-old boy, HIV1-infected since birth, was started on antiretroviral treatment (ART) in August 2015 and was taking a regimen comprising abacavir, lamivudine and efavirenz. Read More

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December 2018
2 Reads

Incidence of Stevens-Johnson syndrome/toxic epidermal necrolysis among new users of different individual drugs in a European population: a case-population study.

Eur J Clin Pharmacol 2018 Oct 8. Epub 2018 Oct 8.

Clinical Pharmacology Unit, Príncipe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain.

Purpose: To estimate the specific incidences of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among new users of drugs frequently reported to be associated with this serious event.

Methods: We performed a case-population approach, which combined data from a registry of SJS/TEN cases from the Madrid region (numerator) during the study period 2005-2015 and a primary healthcare database from the same catchment population. The proportion of new users of drugs estimated in the primary healthcare database was stratified by calendar year, sex and age (5-year bands), and then applied to the same strata of Madrid's population census to compute the number of new users (denominator). Read More

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October 2018
32 Reads

Fluoxetine-induced Stevens-Johnson syndrome and liver injury.

J Clin Pharm Ther 2018 Oct 8. Epub 2018 Oct 8.

Division of Gastroenterology and Hepatology, Department of Medicine, Cook County Health and Hospital System, Chicago, Illinois.

What Is Known And Objective: Drug-induced liver injuries (DILI) are overall rare and often associated with use of medications. Medications are also the most common aetiology of Stevens-Johnson syndrome (SJS), but SJS is seldom seen concomitantly with liver injury. Many common drugs can cause either one of these conditions; however, there are no reported cases of concomitant DILI and SJS secondary to fluoxetine. Read More

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October 2018
14 Reads

Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: Proportion and determinants of underreporting to pharmacovigilance.

J Allergy Clin Immunol Pract 2018 Oct 5. Epub 2018 Oct 5.

EA 7379 EpiDermE, Université Paris Est Créteil, Créteil, France; Department of Dermatology and Reference Center for Toxic Bullous Diseases, Hôpital Henri-Mondor, AP-HP, Créteil, France.

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October 2018
3 Reads

Efficacy and safety of cyclosporine in Stevens-Johnson syndrome and toxic epidermal necrolysis.

Dermatol Ther 2018 Oct 4:e12758. Epub 2018 Oct 4.

Department of Pharmacy, University of Louisville Hospital, Louisville, Kentucky.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life threatening cutaneous reactions that are most commonly caused by exposure to medications. This review assesses the efficacy and safety of cyclosporine therapy for SJS, TEN, and SJS/TEN overlap. A literature review was conducted in PubMed using the MeSH terms TEN, SJS, and cyclosporine. Read More

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October 2018
3 Reads

Post-traumatic stress disorder in Stevens-Johnson syndrome and toxic epidermal necrolysis: prevalence and risk factors. A prospective study of 31 patients.

Br J Dermatol 2018 Oct 3. Epub 2018 Oct 3.

Department of Dermatology, AP-HP, Hôpitaux Universitaires Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, Créteil, F-94010, France.

Background: Epidermal necrolysis is a rare and severe cutaneous adverse reaction to drugs with long-term somatic consequences and potentially underrecognized psychological complications.

Objectives: To assess the prevalence and risk factors of post-traumatic stress disorder (PTSD) in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a population of adults undergoing psychiatric evaluation.

Methods: In this prospective study, we included adult patients admitted at the acute phase of SJS/TEN to our dermatology department from June 2009 to February 2013. Read More

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October 2018
4 Reads

A New Isolation Method of Human Lacrimal Canaliculus Epithelial Stem Cells by Maintaining Close Association with Their Niche Cells.

Int J Med Sci 2018 30;15(12):1260-1267. Epub 2018 Jul 30.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PRC. 430030.

To investigate whether lacrimal canaliculus epithelial stem cells (LCESC) could be isolated and expanded . The lacrimal canaliculus epithelium of 6 patients with limbal stem cell deficiency (LSCD) caused by alkali burn or Stevens Johnson Syndrome were examined by lacrimal endoscope. Cadaveric eyelids were fixed and prepared for cross section and stained with HE and antibodies against PCK, Vim, p63α, SCF and c-Kit. Read More

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July 2018
1 Read
2.003 Impact Factor

Prognostication Using SCORTEN Severity of Illness Score in Patients With Stevens Johnson Syndrome and Toxic Epidermal Necrolysis.

J Pain Symptom Manage 2018 Sep 29. Epub 2018 Sep 29.

Division of Geriatrics and Palliative Care, Department of Family and Community Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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September 2018
2 Reads

Reasons for inpatient admissions to the dermatology department in Lomé, Togo : Trends between 1992 to 2005 and 2005 to 2016.

Med Sante Trop 2018 Aug;28(3):270-272

CHU Sylvanus Olympio, Lomé, Togo.

The aim of this study was to report the frequency of and reasons for dermatology admissions in Lomé (Togo) between 2005 and 2016. This retrospective study examined records from August 2005 to December 2016 from the dermatology departments of the two teaching hospitals in Lomé, Togo. During the study period, 454 (1. Read More

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August 2018
1 Read

A Study of Cutaneous Adverse Drug Reactions in a Tertiary Care Center in Punjab.

Indian Dermatol Online J 2018 Sep-Oct;9(5):299-303

Department of Pharmacology, Christian Medical College and Hospital, Ludhiana, Punjab, India.

Context: Cutaneous adverse drug eruptions are the most common adverse reactions attributed to drugs in which any type of skin reaction can be mimicked, induced, or aggravated.

Aims: To study the pattern of various types of cutaneous adverse drug reactions (CADRs), to find out the causative drug(s) involved and to determine the response to treatment and outcome in patients with CADRs.

Patients And Methods: This prospective study was done in the department of dermatology. Read More

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September 2018
9 Reads

Anticancer Agent-Induced Life-Threatening Skin Toxicities: A Database Study of Spontaneous Reporting Data.

Oncologist 2018 Sep 25. Epub 2018 Sep 25.

Divisions of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially life-threatening cutaneous and mucosal adverse reactions to drugs. Nevertheless, the connection to anticancer agents remains unclear. To provide insight into the association of such adverse reactions with anticancer agents, we analyzed the profile of anticancer agent-induced SJS and TEN in the Japanese population. Read More

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September 2018
7 Reads

A liver-immune coculture array for predicting systemic drug-induced skin sensitization.

Lab Chip 2018 Oct;18(21):3239-3250

Department of Biomedical Engineering, National University of Singapore, Singapore.

Drug-induced skin sensitization is prevalent worldwide and can trigger life-threatening health conditions, such as Stevens Johnson Syndrome. However, existing in vitro skin models cannot adequately predict the skin sensitization effects of drugs administered into the systemic circulation because dermal inflammation and injury are preceded by conversion of parent drugs into antigenic reactive metabolites in the liver and subsequent activation of the immune system. Here, we demonstrate that recapitulation of these early tandem cellular processes in a compartmentalized liver-immune coculture array is sufficient to predict the skin sensitization potential of systemic drugs. Read More

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October 2018
11 Reads

Association between HLA-B*5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis.

Pharmacogenomics J 2018 Sep 21. Epub 2018 Sep 21.

Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.

Methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening adverse drug reactions. Based on previous studies, HLA genotypes may play an important role in methazolamide-induced SJS/TEN. Therefore, to identify the associations between HLA genotypes and methazolamide-induced cutaneous adverse drug reactions (cADRs) (i. Read More

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September 2018
6 Reads
4.230 Impact Factor

Lamotrigine-Valproic Acid Interaction Leading to Stevens-Johnson Syndrome.

Case Rep Med 2018 29;2018:5371854. Epub 2018 Aug 29.

Genia-Genetics Molecular Laboratory, Bulevar General Artigas 922, 11300 Montevideo, Uruguay.

Lamotrigine (LTG) is currently indicated as adjunctive therapy for focal and generalized tonic-clonic seizures and for treatment of bipolar disorder and neuropathic pain. A common concern with LTG in children is the frequency of appearance of skin rash. The intensity of this adverse effect can vary from transient mild rash to Stevens-Johnson syndrome (SJS), which can be fatal mainly when LTG is coadministered with valproic acid (VPA). Read More

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August 2018
2 Reads

Rechallenge of lamotrigine after development of rash.

Ment Health Clin 2018 Sep 30;8(5):247-249. Epub 2018 Aug 30.

PACT/Behavioral Health Clinical Pharmacy Specialist, Wm. Jennings Bryan Dorn VA Medical Center, Columbia, South Carolina.

Lamotrigine (LTG) is associated with the potential for a life-threatening rash (eg, Stevens-Johnson syndrome or toxic epidermal necrolysis). The incidence has been linked to rapid titration and an interaction with valproic acid that can increase the level of LTG. Providers often have difficulty discriminating between serious versus benign rashes, and the package insert recommends discontinuing the medication at the first sign of a rash. Read More

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September 2018
2 Reads

The influence of acute kidney injury on the outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis: The prognostic value of KDIGO staging.

PLoS One 2018 7;13(9):e0203642. Epub 2018 Sep 7.

Kidney Research Center, Department of Nephrology, Change Gung Memorial Hospital, Linkou branch, Taoyuan, Taiwan.

Background: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are severe drug-induced cutaneous adverse reactions with high mortality. Acute kidney injury (AKI) was a common complication in an SJS/TEN group and noted as an independent risk factor for mortality in patients with SJS/TEN. To determine whether AKI staging can predict the outcome of patients with SJS/TEN, we compared the discriminative power of an AKI KDIGO staging system with that of SCROTEN, APACHE II, APACHE III, and SOFA. Read More

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September 2018
7 Reads
3.234 Impact Factor

Atezolizumab-Induced Stevens-Johnson Syndrome in a Patient with Non-Small Cell Lung Carcinoma.

Case Rep Dermatol 2018 May-Aug;10(2):198-202. Epub 2018 Aug 9.

Division of Dermatology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Atezolizumab is a humanized anti-PD-L1 immune checkpoint antibody that is currently used in many kinds of advanced carcinoma including metastatic non-small cell lung cancer. The cutaneous side effect profile reported only 20$ of the patients which had only mild maculopapular rash that required no treatment. There is no case report of anti-PD-L1 antibody-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) eruptions. Read More

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August 2018
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Successful Treatment of Stevens-Johnson Syndrome with Cyclosporine and Corticosteroid.

Can J Hosp Pharm 2018 Jul-Aug;71(4):272-275. Epub 2018 Aug 28.

, BScPhm, MSc, PharmD, RPh, is the Elder Care Pharmacy Practitioner with North York General Hospital and an Adjunct Lecturer with the Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario.

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August 2018
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