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    A cross-sectional comparative study on chronic ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series.
    Int Ophthalmol 2017 May 25. Epub 2017 May 25.
    Department of Ophthalmology, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pokfulam, Hong Kong.
    Purpose: To compare the chronic ocular manifestations in Stevens-Johnson syndrome and toxic epidermal necrolysis patients from a 15-year cohort.

    Methods: All SJS and TEN patients admitted to our burn intensive care unit between 1999 and 2014 were invited for assessment. Slit-lamp examination was performed, and ocular condition was graded according to the Sotozono scoring System, which depended on the extent of cornea, conjunctiva and lid involvement. Read More

    Efficacy and Adverse Events of Oral Isotretinoin for Acne: A Systematic Review.
    Br J Dermatol 2017 May 19. Epub 2017 May 19.
    Dept. of Community Health Sciences, Cumming School of Medicine, University of Calgary.
    Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in acne patients is lacking. We searched MEDLINE, EMBASE, Cochrane Central, relevant webpages and bibliographies for randomized controlled trials for acne evaluating isotretinoin vs control (placebo or other therapy). Data were extracted and summarized descriptively. Read More

    The effect of comorbidities on overall mortality in Stevens- Johnson Syndrome: an analysis of the Nationwide Inpatient Sample.
    Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.
    Yale School of Medicine Department of Dermatology, New Haven, Connecticut.
    Background: Stevens Johnson Syndrome (SJS) is a life threatening skin condition with an overall mortality rate of 5%. Although the causes and pathology of the disease have been well studied, the factors that significantly contribute to mortality remain unclear.

    Objective: To determine relevant risk factors that increase the likelihood of inpatient mortality after diagnosis of SJS. Read More

    Negative wound pressure therapy is safe and useful in pediatric burn patients.
    Int J Burns Trauma 2017 15;7(2):12-16. Epub 2017 Apr 15.
    Shriners Hospital for ChildrenBoston, MA, America.
    Introduction: Negative Pressure Wound Therapy (NPWT) has proven to be a powerful tool in facilitating healing of difficult wounds of a variety of etiologies. The pediatric experience with NPWT has been limited due to concerns about vascular compression and pain associated with treatment.

    Method: A retrospective review was performed to evaluate the therapeutic effect of NPWT on children with difficult wounds due to burns or soft-tissue trauma. Read More

    The use of Biobrane(®) for wound coverage in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Burns 2017 May 16. Epub 2017 May 16.
    Ross Tilley Burn Centre, Toronto, Canada. Electronic address:
    Introduction: Published experience describing the use of Biobrane(®) for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane(®) in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane(®) for wound coverage in SJS-TEN.

    Methods: A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted. Read More

    Cutaneous adverse effects during ipilimumab treatment for metastatic melanoma: a prospective study.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. Read More

    Delayed Stevens-Johnson Syndrome Secondary to the Use of Lamotrigine in Bipolar Mood Disorder.
    Indian J Psychol Med 2017 Mar-Apr;39(2):209-212
    Department of Internal Medicine Possible Health, Achham, Nepal.
    Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. Read More

    Risk factors of allopurinol-induced severe cutaneous adverse reactions in a Thai population.
    Pharmacogenet Genomics 2017 May 15. Epub 2017 May 15.
    aDepartment of Pharmacology bPharmacy Unit cDepartment of Medicine, Faculty of Medicine dResearch and Diagnostic Center for Emerging Infectious Diseases eResearch Center in Back, Neck Other Joint Pain and Human Performance fSleep Apnea Research Group, gFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen hSchool of Pharmaceutical Sciences, University of Phayao, Phayao iPharmacy Unit, Udon Thani Hospital, Udon Thani jDepartment of Pathology, Division of Pharmacogenomics and Personalized Medicine kLaboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center lDivision of Allergy Immunology and Rheumatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok mDepartment of Pharmacy, Phrae Hospital, Phrae nCenter of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand oSchool of Pharmacy pHealth and Well-being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Malaysia qSchool of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA.
    Background: Allopurinol is one of the most common causes of severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). This study identified the risk factors associated with the development of allopurinol-induced SCARs in a Thai population.

    Patients And Methods: Eighty-six allopurinol-induced SCARs (i. Read More

    Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim-sulfamethoxazole.
    CEN Case Rep 2016 Nov 7;5(2):188-191. Epub 2016 Jun 7.
    Division of Nephrology, Department of Medicine, St. Elizabeth's Medical Center, 736 Cambridge Street, Boston, MA, 02135, USA.
    Drug-induced pauci-immune crescentic glomerulonephritis has been described with several agents, including propylthiouracil, minocycline, D-penicillamine, and hydralazine. We present the case of a 60-year-old man who presented with rapidly progressive glomerulonephritis in the setting of recent use of trimethoprim-sulfamethoxazole complicated by the development of the Stevens-Johnson syndrome, and was found to have biopsy-proven pauci-immune crescentic glomerulonephritis and undetectable anti-neutrophilic cytoplasmic antibodies. We review the existing literature on the potential association between sulfonamides and hypersensitivity polyangiitis. Read More

    Score of Toxic Epidermal Necrosis Predicts the Outcomes of Pediatric Epidermal Necrolysis.
    Pediatr Dermatol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    Background/objectives: Epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) includes immune-mediated, life-threatening inflammatory blistering disorders that can affect children. The Score of Toxic Epidermal Necrosis (SCORTEN) tool has accurately predicted the outcome of these disorders in adults but has not been tested in children.

    Methods: We performed a retrospective chart review to compare the accuracy of the adult SCORTEN tool with that of two modifications tailored to children in predicting disease outcome. Read More

    Methotrexate-induced epidermal necrosis: A case series of 24 patients.
    J Am Acad Dermatol 2017 May 10. Epub 2017 May 10.
    Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Background: Methotrexate-induced epidermal necrosis (MEN) is a rare but life-threatening cutaneous reaction that mimics Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

    Objectives: To investigate the clinicopathology, risk factors, and prognostic factors of MEN.

    Methods: We enrolled 24 patients with MEN and 150 controls and analyzed the demographics, pathology, and plasma concentrations of methotrexate (MTX). Read More

    Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study.
    BMC Ophthalmol 2017 May 12;17(1):65. Epub 2017 May 12.
    Department of Ophthalmology, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pok Fu Lam, Hong Kong.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN.

    Methods: The initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared. Read More

    Eruptive melanocytic nevi during azathioprine therapy for antisynthetase syndrome.
    Cutis 2017 Apr;99(4):268-270
    Department of Dermatology, University of Maryland Medical Center, Baltimore, USA.
    Eruptive melanocytic nevi (EMN) are rare multiple benign melanocytic nevi that develop within a few months. The phenomenon has been associated with a variety of dermatologic and systemic conditions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermolysis bullosa, Addison disease, human immunodeficiency virus infection, and internal malignancy, among others. It also is commonly attributed to medications, particularly immunosuppressive and chemotherapeutic agents. Read More

    Stevens-Johnson syndrome/toxic epidermal necrolysis caused by cefadroxil in a cat.
    JFMS Open Rep 2016 Jan-Jun;2(1):2055116916653616. Epub 2016 Jun 6.
    Servizi Dermatologici Veterinari, Legnano, Milan, Italy.
    Case Summary: A 5-year-old, spayed female, indoor-only domestic shorthair cat was referred with an acute history of multifocal cutaneous and mucocutaneous erosive-ulcerative lesions and skin detachment. The lesions occurred on the seventh day of therapy with cefadroxil. Erosive-ulcerative and occasionally crusted lesions were apparent on the medial and lateral canthus of both eyes, ventral neck, abdomen, perivulvar region, periungual skin and medial aspect of the front and hindlimbs. Read More

    Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Treatment With a Biologic: A Case Report.
    Perm J 2017 ;21
    Attending Physician in Emergency Medicine at the Santa Clara Medical Center in CA.
    Introduction: One of the most dangerous dermatologic emergencies is Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN). Although a rare disease, it can often lead to significant mortality.

    Case Presentation: In this case report, we present a 77-year-old man who developed a sloughing rash that was secondary to a nonsteroidal anti-inflammatory drug. Read More

    Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice.
    J Allergy Clin Immunol Pract 2017 May - Jun;5(3):547-563
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia. Electronic address:
    Most immune-mediated adverse drug reactions (IM-ADRs) involve the skin, and many have additional systemic features. Severe cutaneous adverse drug reactions (SCARs) are an uncommon, potentially life-threatening, and challenging subgroup of IM-ADRs with diverse clinical phenotypes, mechanisms, and offending drugs. T-cell-mediated immunopathology is central to these severe delayed reactions, but effector cells and cytokines differ by clinical phenotype. Read More

    Ivermectin induced Steven-Johnsons syndrome: case report.
    BMC Res Notes 2017 May 8;10(1):179. Epub 2017 May 8.
    Presbyterian General Hospital Acha-Tugi, Acha, Cameroon.
    Background: Stevens-Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit. A 38 year old adult Cameroonian male presented to our health facility with facial rash, painful oral sores, black eschars on lips and red tearing eyes 3 days following ingestion of ivermectin received during a nationwide anti-filarial campaign. Read More

    HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.
    Neurology 2017 May 5. Epub 2017 May 5.
    Author affiliations are provided at the end of the article.
    Objective: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions.

    Methods: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Read More

    Severe cutaneous adverse reactions to drugs.
    Lancet 2017 May 2. Epub 2017 May 2.
    Department of Dermatology, Hôpital Henri-Mondor, AP-HP, Créteil, France; Centre de Référence des Dermatoses Bulleuses Toxiques, Créteil, France; EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), Université Paris-Est Créteil Val-de-Marne, Créteil, France; French Satellite of the Cochrane Skin Group, Créteil, France; INSERM, Centre d'Investigation Clinique 1430, Créteil, France.
    During the past decade, major advances have been made in the accurate diagnosis of severe cutaneous adverse reactions (SCARs) to drugs, management of their manifestations, and identification of their pathogenetic mechanisms and at-risk populations. Early recognition and diagnosis of SCARs are key in the identification of culprit drugs. SCARS are potentially life threatening, and associated with various clinical patterns and morbidity during the acute stage of Stevens-Johnson syndrome and toxic epidermal necrolysis, drug reactions with eosinophilia and systemic symptoms, and acute generalised exanthematous pustulosis. Read More

    Response to: Milosavljevic et al. "Two cases of RIT1 associated Noonan syndrome: Further delineation of the clinical phenotype and review of the literature".
    Am J Med Genet A 2017 May 5. Epub 2017 May 5.
    Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School at UT Health and The Fetal Center at Children's Memorial Hermann Hospital, Houston, Texas.

    Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription.
    Case Rep Dent 2017 3;2017:4201357. Epub 2017 Apr 3.
    Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, UKM and UKM Medical Centre, Kuala Lumpur, Malaysia.
    Failure to screen susceptible individuals for human leucocyte allele B∗1502 leads to the onset of Stevens-Johnson syndrome (SJS). We report a case of a 27-year-old Malay female who was treated with carbamazepine following the diagnosis of trigeminal neuralgia without a genetic screening. She was prescribed 150 mg of carbamazepine initially and the dose was increased to 300 mg following the initial dose. Read More

    Retrospective Analysis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in 88 Chinese Patients.
    Chin Med J (Engl) 2017 May;130(9):1062-1068
    Department of Dermatology, Allergy and Clinical Immunology Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases with high mortality rates. This study was designed to analyze the pathogenic factors, clinical manifestations, complications, treatment, and prognosis of SJS/TEN and to explore the differences between surviving and deceased patients.

    Methods: SJS/TEN patients admitted to Beijing Friendship Hospital from January 2006 to December 2015 were included in the study. Read More

    Functional Chemical Groups That May Likely Become Source For Synthesis of Novel Central Nervous System (Cns) Acting Drugs.
    Cent Nerv Syst Agents Med Chem 2017 May 2. Epub 2017 May 2.
    Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, P.M.B. 2373, Makurdi, Benue State. Nigeria.
    Central nervous system (CNS) disorders are on increase perhaps due to genetic, enviromental, social and dietetic factors. Unfortunately, a large number of CNS drugs have adverse effects such as addiction, tolerance, psychological and physical dependence. In view of this, literature search was carried out with a view to identifying functional chemical groups that may serve as lead molecule for synthesis of compounds that may have CNS activity. Read More

    Factors Contributing to Long-Term Severe Visual Impairment in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    J Ophthalmol 2017 26;2017:2087578. Epub 2017 Mar 26.
    Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Purpose. To study the correlation between demographics and clinical variables and long-term severe visual impairment in patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Methods. Read More

    Amniotic membrane transplants in the pediatric population.
    J AAPOS 2017 Apr 24. Epub 2017 Apr 24.
    Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.
    Purpose: To investigate the indications for and results of amniotic membrane transplantation (AMT) for the treatment of ocular disease in pediatric patients at a single institution.

    Methods: The medical records of patients <18 years of age who underwent AMT for ocular disease between January 1, 2003, and September 1, 2015, were reviewed retrospectively. Patients were determined to have reached a clinical endpoint if there was resolution of the ocular condition being treated after AMT placement, no additional surgery required for treatment of the ocular condition, and no active disease at most recent follow-up. Read More

    External quality assessment for laboratory testing of HLA-B*15:02 allele in relation to carbamazepine therapy.
    J Clin Lab Anal 2017 Apr 25. Epub 2017 Apr 25.
    National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, China.
    Background: Due to the significant risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the use of carbamazepine is not recommended in patients carrying the human leukocyte antigen B (HLA-B) *15:02 allele. In an effort to guarantee reliable community-based HLA-B*15:02 testing throughout China, a HLA-B*15:02 genotyping external quality assessment (EQA) program was set up.

    Methods: In 2016, 10 genomic DNA samples with known HLA-B*15:02 allele status were sent to 37 laboratories from 16 provinces with a request for routine HLA-B*15:02 screening. Read More

    Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Concise Review with a Comprehensive Summary of Therapeutic Interventions Emphasizing Supportive Measures.
    Adv Ther 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, University of California, San Diego, La Jolla, CA, USA.
    Introduction: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe dermatologic conditions occurring in the inpatient setting. There is a lack of consensus regarding appropriate management of SJS and TEN.

    Purpose: The scientific literature pertaining to SJS and TEN (subsequently referred to as SJS/TEN) is summarized and assessed. Read More

    Association of human leukocyte antigen variants and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A meta-analysis.
    Am J Health Syst Pharm 2017 May;74(9):e183-e192
    College of Pharmacy, Western New England University, Springfield, MA.
    Purpose: The association between human leukocyte antigen (HLA) variants and allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) was evaluated through a pooled analysis of published studies.

    Methods: A comprehensive search was performed in multiple databases, including PubMed, MEDLINE, ISI Web of Knowledge, EMBASE, Cochrane Register of Controlled Trials, and Science Direct. Studies investigating the association between HLA alleles with allopurinol-induced SJS or TEN were retrieved, and the data were independently extracted. Read More

    Are steroids effective in toxic epidermal necrolysis and Stevens-Johnson syndrome?
    Medwave 2017 Apr 5;17(Suppl2):e6894. Epub 2017 Apr 5.
    Proyecto Epistemonikos, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Toxic epidermal necrolysis and Stevens-Johnson syndrome are severe adverse skin reactions to medications and infections. Steroids are described as a therapeutic alternative, but their use is still controversial. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. Read More

    Trends in culprit drugs and clinical entities in cutaneous adverse drug reactions: a retrospective study.
    Cutan Ocul Toxicol 2017 Apr 19:1-7. Epub 2017 Apr 19.
    a Department of Dermatology , First Affiliated Hospital, Sun Yat-sen University , Guangzhou , China.
    Purpose: Morbidity due to cutaneous adverse drug reactions (CADRs) is quite common. The specific culprit drugs change over time and clinicians must be kept informed with updated knowledge, thus preventing potential CADRs. This retrospective study is a survey of CADRs encountered in a hospital-based population in Southern China during three time intervals, from 1984 to 2015. Read More

    [Epicutaneous patch testing in delayed drug hypersensitivity reactions induced by antiepileptic drugs].
    Therapie 2017 Mar 25. Epub 2017 Mar 25.
    Centre régional de pharmacovigilance de Sfax, faculté de médecine de Sfax, avenue Majida-Boulila, 3029 Sfax, Tunisie.
    Introduction: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. Read More

    Cutaneous allergic drug reactions: update on pathophysiology, diagnostic procedures and differential diagnosic.
    Cutan Ocul Toxicol 2017 Apr 27:1-10. Epub 2017 Apr 27.
    a Department of Dermatology and Allergology , RWTH Aachen University , Aachen , Germany.
    Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions. Read More

    Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology-Thirty Years of Progress but Still Much to Be Done.
    J Invest Dermatol 2017 May;137(5):1004-1008
    Brigham and Women's Hospital Ringgold Standard Institution-Dermatology, Boston, Massachusetts, USA.
    Although rare, Stevens-Johnson syndrome and toxic epidermal necrolysis remain among the most devastating of acute conditions involving the skin. In the past 30 years, tremendous progress has been made in understanding the causes and pathobiology of this often life-threatening condition. Su et al demonstrate associations between IL 15 serum levels and the outcome of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. Read More

    Fever in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy.
    Pediatr Infect Dis J 2017 May;36(5):513-515
    From the Department of Dermatology, Dokumentationszentrum schwerer Hautreaktionen (dZh), Medical Center-University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany.
    Fever is a symptom that often accompanies skin eruptions, especially in children. It can be a sign of an infectious condition presenting with exanthems or it may precede an exanthematous eruption. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactions affecting skin and mucosa with blisters and erosions. Read More

    Characterization of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Among Patients Admitted to Kenyatta National Hospital: A Retrospective Cross-Sectional Study.
    Drugs Real World Outcomes 2017 Apr 11. Epub 2017 Apr 11.
    Department of Pharmaceutics and Pharmacy Practice, School of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous reactions. There is scant literature on the characteristics and causes of these conditions in Kenyatta National Hospital.

    Objective: The aim of this study was to determine the prevalence, risk factors, and etiologies of SJS/TEN among patients admitted to Kenyatta National Hospital. Read More

    Imatinib mesylate-induced lichenoid drug eruption.
    Cutis 2017 Mar;99(3):189-192
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA.
    Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Read More

    Long-term safety experience with bendamustine for injection in a real-world setting.
    Expert Opin Drug Saf 2017 Jun 17;16(6):647-650. Epub 2017 Apr 17.
    e Division of Medical Oncology , Washington University School of Medicine , St. Louis , MO , USA.
    Background: Bendamustine hydrochloride (bendamustine) was approved for first-line treatment of patients with chronic lymphocytic leukemia (CLL) and relapsed indolent B-cell non-Hodgkin's lymphoma (NHL). Pharmacovigilance data have been collected since bendamustine's approval to enhance understanding of its long-term safety profile. Here we provide an overview of the pharmacovigilance data for bendamustine that have led to label updates related to safety and administration since its approval. Read More

    Influence of genetic and non-genetic factors on phenytoin-induced severe cutaneous adverse drug reactions.
    Eur J Clin Pharmacol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phyathai Rd.,Wangmai, Patumwan, Bangkok, 10330, Thailand.
    Purpose: The purpose of this study was to investigate the association of genetic factors including variants in HLA-B and CYP2C genes and non-genetic factors with phenotype-specific phenytoin (PHT)-induced severe cutaneous adverse reactions (SCARs) in Thai patients.

    Methods: Thirty-six PHT-induced SCAR cases (15 Stevens-Johnson syndrome (SJS) and 21 drug rash with eosinophilia and systemic symptoms (DRESS)/drug hypersensitivity syndrome (DHS)) and 100 PHT-tolerant controls were studied. Variants in HLA-B, CYP2C9, and CYP2C19 genes were genotyped. Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis in childhood-onset systemic lupus erythematosus patients: a multicenter study.
    Acta Reumatol Port 2017 Mar 26. Epub 2017 Mar 26.
    Universidade Federal de São Paulo (UNIFESP).
    Objective: To assess Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a large population of childhood-onset systemic lupus erythematosus (cSLE) patients.

    Methods: Multicenter study including 852 cSLE patients followed in Pediatric Rheumatology centers in São Paulo, Brazil. SJS was defined as epidermal detachment below 10% of body surface area (BSA), overlap SJS-TEN 10-30% and TEN greater than 30% of BSA. Read More

    Effectiveness, safety and tolerability of cyclosporine versus supportive treatment in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A record-based study.
    Indian J Dermatol Venereol Leprol 2017 May-Jun;83(3):312-316
    Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.
    Background: Toxic epidermal necrolysis and Stevens-Johnson syndrome comprise life-threatening, drug-induced mucocutaneous disease spectrum. Interest in cyclosporine, a calcineurin inhibitor that can block the function of T-cells, has increased with the discovery of the importance of granulysin in apoptosis in toxic epidermal necrolysis. In our hospital, cyclosporine is given to Stevens-Johnson syndrome/toxic epidermal necrolysis patients as an adjunctive therapy. Read More

    Change in vault during scleral lens trials assessed with anterior segment optical coherence tomography.
    Cont Lens Anterior Eye 2017 Mar 30. Epub 2017 Mar 30.
    Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.
    Purpose: To assess the change in vault during scleral lens fitting with anterior segment optical coherence tomography (AS-OCT).

    Methods: This study comprised of patients who had AS-OCT performed after 1h and 4h of scleral lens wear (PROSE, prosthetic replacement of the ocular surface ecosystem, Boston Foundation for Sight, Needham Heights, MA, USA). Vault was measured on AS-OCT as the distance between the front surface of the cornea in the center and the back surface of the scleral lens. Read More

    HLA-B*15:21 and carbamazepine-induced Stevens-Johnson syndrome: pooled-data and in silico analysis.
    Sci Rep 2017 Mar 30;7:45553. Epub 2017 Mar 30.
    Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
    HLA-B*15:02 screening before carbamazepine (CBZ) prescription in Asian populations is the recommended practice to prevent CBZ-induced Stevens-Johnson syndrome (CBZ-SJS). However, a number of patients have developed CBZ-SJS even having no HLA-B*15:02. Herein, we present the case of a Thai patient who had a negative HLA-B*15:02 screening result but later developed CBZ-SJS. Read More

    Severe Cutaneous Adverse Drug Reactions in Pediatric Patients: A Multicenter Study.
    J Allergy Clin Immunol Pract 2017 May - Jun;5(3):757-763. Epub 2017 Mar 27.
    Division of Pediatric Allergy and Immunology, Department of Children's Health and Diseases, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey. Electronic address:
    Background: The severe cutaneous adverse drug reactions (SCARs) are rare but could be life-threatening. These include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis.

    Objective: The purpose of this study was the evaluation of the clinical characteristics of patients with the diagnosis of SCARs. Read More

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