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    1 OF 113

    Identifying the incidence of rash, Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: a systematic review of 122 randomized controlled trials.
    An Bras Dermatol 2017 Jan-Feb;92(1):139-141
    University of California Irvine, Department of Dermatology - Irvine, California.
    Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. Read More

    Lakartidningen 2017 Feb 21;114. Epub 2017 Feb 21.
    Karolinska Universitetssjukhuset Neurologiska kliniken - Stockholm, Sweden Karolinska Universitetssjukhuset Neurologiska kliniken - Stockholm, Sweden.
    Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B*15:02 gene carrier - screening in risk patients is recommended A 32-year-old woman, adopted from Indonesia, developed Stevens-Johnsons syndrome (SJS)/toxic epidermal necrolysis (TEN) after initiating carbamazepine treatment for epilepsy. SJS and TEN are rare but life-threatening adverse effects of carbamazepine, with a 72-100% risk of occurrence in patients carrying the HLA-B*15:02 allele. The HLA-B*15:02 allele is common in several Asian groups but less prevalent in European populations. Read More

    Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case.
    J Clin Diagn Res 2016 Dec 1;10(12):FD01-FD03. Epub 2016 Dec 1.
    Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
    Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. Read More

    A study of HLA-B*15:02 in 9 different Chinese ethnics: Implications for carbamazepine related SJS/TEN.
    HLA 2017 Feb 15. Epub 2017 Feb 15.
    Clinical Blood Transfusion Research Center, Institute of Blood Transfusion, CAMS & PUMC, Chengdu, China.
    Background: HLA-B*15:02 is a known biomarker for carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some ethnic populations. The US FDA recommends B*15:02 screening for Asian and other populations with a high prevalence of B*15:02 prior to treatment with CBZ to prevent drug-related SJS/TEN.

    Materials And Methods: A total of 1607 blood samples were collected from volunteer blood donors who were ethnic minorities living in the Yunnan province of southwestern China, including 153 Yi, 193 Naxi, 167 Miao, 156 Lisu, 166 Derung, 211 Bai, 184 Hani, 198 Dai, and 179 Zhuang. Read More

    An exploratory factor analysis of the spontaneous reporting of severe cutaneous adverse reactions.
    Ther Adv Drug Saf 2017 Jan 29;8(1):4-16. Epub 2016 Nov 29.
    Pfizer Inc., New York, NY, USA.
    Background: Severe cutaneous adverse reactions (SCARs) are prominent in pharmacovigilance (PhV). They have some commonalities such as nonimmediate nature and T-cell mediation and rare overlap syndromes have been documented, most commonly involving acute generalized exanthematous pustulosis (AGEP) and drug rash with eosinophilia and systemic symptoms (DRESS), and DRESS and toxic epidermal necrolysis (TEN). However, they display diverse clinical phenotypes and variations in specific T-cell immune response profiles, plus some specific genotype-phenotype associations. Read More

    The HLA-A*31:01 allele: influence on carbamazepine treatment.
    Pharmgenomics Pers Med 2017 31;10:29-38. Epub 2017 Jan 31.
    MRC Centre for Drug Safety Science, Institute of Translational Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool; Department of Clinical Pharmacology, The Royal Liverpool and Broadgreen University Hospital NHS Trust, Liverpool, UK.
    Carbamazepine (CBZ) is an effective anticonvulsant that can sometimes cause hypersensitivity reactions that vary in frequency and severity. Strong associations have been reported between specific human leukocyte antigen (HLA) alleles and susceptibility to CBZ hypersensitivity reactions. Screening for HLA-B*15:02 is mandated in patients from South East Asia because of a strong association with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Read More

    The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the UK.
    J Invest Dermatol 2017 Feb 12. Epub 2017 Feb 12.
    Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; Hospital Pharmacy, University Hospital Basel, Basel, Switzerland.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening mucocutaneous diseases. SJS/TEN mostly manifest as a reaction to new drug use, but little is known about their incidence and epidemiology. We conducted a large observational study on the epidemiology of SJS/TEN using data from the UK-based Clinical Practice Research Datalink. Read More

    ISMP Adverse Drug Reactions: Acute Disseminated Intravascular Coagulation Due to Oxaliplatin Azithromycin-Induced Stevens-Johnson Syndrome Acute Jugular Vein Thrombosis with Rituximab Hemorrhagic Bullae of the Fingers Induced by Furosemide.
    Hosp Pharm 2017 Jan;52(1):13-16
    The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Read More

    Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats.
    Hum Exp Toxicol 2017 Jan 1:960327117692135. Epub 2017 Jan 1.
    Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, Makurdi, Benue State, Nigeria.
    Cases of Stevens-Johnson syndrome have been increasingly reported in Nigeria by individuals who consumed meat products of animals especially goats injected sulfonamides. Hence, tissue distribution and residues of intramuscular sulfadimidine were studied in West African Dwarf (WAD) goats. Twenty goats divided into two groups of 10 each (five males; five females) weighing 10. Read More

    Long term complications of Stevens-Johnson syndrome / Toxic epidermal necrolysis: The spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multi-disciplinary follow up.
    Br J Dermatol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Dermatology, King's College Hospital, London.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse reactions to drugs which cause a life-threatening eruption of mucocutaneous blistering and epithelial sloughing. The two terms describe phenotypes occurring at either end of a severity spectrum: SJS is the less extensive form (<10% body surface area (BSA) detachment), while TEN is the more extensive (>30% BSA detachment). Cases in which there is 10-30% epidermal detachment are referred to as SJS-TEN overlap. Read More

    The metabolism of methazolamide in immortalized human keratinocytes, HaCaT cells.
    Drug Metab Lett 2017 Jan 27. Epub 2017 Jan 27.
    Department of Ophthalmology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1 Habikino, Habikino-shi Osaka 583-8588, Japan.
    Objective: Drug therapy is occasionally accompanied by an idiosyncratic severe toxicity, which occurs very rarely, but can lead to patient mortality. Methazolamide, an anti-glaucomatous agent, could cause severe skin eruptions called Stevens-Johnson syndrome/toxic epidermal necrolyis (SJS/TEN). Its precise etiology is still uncertain. Read More

    Acute Generalized Erythrodermic Pustular Psoriasis Associated with Bupropion/Naltrexone (Contrave(®)).
    J Emerg Med 2017 Jan 24. Epub 2017 Jan 24.
    Department of Emergency Medicine, Erie County Medical Center, Buffalo, New York.
    Background: We report a case of erythrodermic pustular psoriasis associated with initiation of bupropion/naltrexone (Contrave®; Orexigen Therapeutics, La Jolla, CA) in a patient with no history of psoriasis.

    Case Report: A 55-year-old woman was transferred to our tertiary medical center from a community hospital for possible Stevens-Johnson syndrome 3 weeks after initiation of bupropion/naltrexone. The patient was admitted to the burn unit for wound treatment and hydration. Read More

    Are Idiopathic Stevens-Johnson syndrome/Toxic Epidermal Necrolysis Related to Drugs in Food? Example of Phenylbutazone.
    J Invest Dermatol 2017 Jan 17. Epub 2017 Jan 17.
    APHP, Laboratory of Pharmacology, Hôpitaux Universitaires Henri Mondor, F-94000, Créteil, France; Département Hospitalo-Universitaire Virus Immunité Cancer, F-94000, Créteil, France. Electronic address:

    Antiepileptic Drugs-induced Stevens-Johnson syndrome: A case Series.
    J Basic Clin Pharm 2016 Dec;8(1):42-44
    Department of Pharmacology, Smt. NHL Municipal Medical College, VS General Hospital, Ahmedabad, Gujarat, India.
    Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Read More

    Spectrum of Cutaneous Adverse Reactions to Levetiracetam and Human Leukocyte Antigen Typing in North-Indian Patients.
    J Epilepsy Res 2016 Dec 31;6(2):87-92. Epub 2016 Dec 31.
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
    Background And Purpose: Aromatic antiepileptic drugs are frequently implicated for cutaneous adverse drug reactions (cADRs); there are case-reports of even severe reactions like drug reaction eosinophilia and systemic symptoms (DRESS) and Stevens Johnson syndrome (SJS)-toxic epidermal necrolysis with Levetiracetam (LEV). Certain human leukocyte antigen (HLA)-alleles have strong association with cADRs due to specific drugs - HLA-B*15:02 and HLA-A*31:01 in Carbamazepine (CBZ)-related SJS in Han-Chinese and European populations, respectively. Here, the spectrum of cADRs to LEV was studied, and HLA-typing in patients with cADRs due to LEV and some who were LEV-tolerant was performed, in an attempt to find an association between HLA and such reactions. Read More

    Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications.
    J Hum Genet 2017 Jan 19. Epub 2017 Jan 19.
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
    A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16. Read More

    Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 - 2015.
    Orphanet J Rare Dis 2017 Jan 18;12(1):14. Epub 2017 Jan 18.
    College of Medicine and Health Sciences, Department of Physiology and Pharmacology/Toxicology, An-Najah National University, Nablus, Palestine.
    Background: Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse skin reactions that affect all age groups. In order to better understand literature on this topic, we conducted a bibliometric study using Scopus database to shed light on number and growth of publications, most active countries, institutions, journals and authors involved in publishing articles in this field, citation analysis, top cited articles, international collaboration, role of medications and genetic association. Bibliometric analysis will enrich the literature on these rare conditions and will provide baseline data for future comparison. Read More

    Conjunctival impression cytology evaluation of patients with dry eye disease using scleral contact lenses.
    Cont Lens Anterior Eye 2017 Jan 6. Epub 2017 Jan 6.
    Department of Ophthalmology, Ocular Surface Advanced Center, Federal University of Sao Paulo, 821 Botucatu St-Vila Clementino, Sao Paulo, SP, 04023-062, Brazil.
    Purpose: To evaluate conjunctival impression cytology and HLADR expression changes after wearing scleral contact lenses (ScCLs) for moderate to severe dry eye disease (DED).

    Design: Prospective interventional case series.

    Methods: Forty-one eyes from 25 patients with moderate to severe DED were evaluated for Esclera ScCL treatment. Read More

    Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap.
    Clin Exp Dermatol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Dermatology, Alfred Hospital, Melbourne, VIC, Australia.
    Linear IgA bullous dermatosis (LABD) is a subepidermal autoimmune bullous disease characterized by linear IgA deposition at the basement membrane zone, which is visualized by direct immunofluorescence. Patients with LABD typically present with widespread vesicles and bullae; however, this is not necessarily the case, as the clinical presentation of this disease is heterogeneous. LABD clinically presenting as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is an infrequent, yet well-described phenomenon. Read More

    Microbiological findings and antibacterial therapy in Stevens-Johnson syndrome/toxic epidermal necrolysis patients from a Swedish Burn Center.
    J Cutan Pathol 2017 Jan 11. Epub 2017 Jan 11.
    Uppsala Burn Centre, Department of Plastic and Maxillofacial Surgery, Uppsala University Hospital, Uppsala, Sweden.
    Background: Superimposed infections/sepsis are the major cause of morbidity/mortality in Stevens-Johnson syndrome/Toxic Epidermal Necrolysis (SJS/TEN). It is a delicate balance between avoiding new pharmaceuticals and prophylactically treat an incipient infection. The objective of this study was to investigate the rates and types of infection-microbials and antibiotics involved in SJS/TEN patients. Read More

    Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.
    J Antimicrob Chemother 2017 Jan 6. Epub 2017 Jan 6.
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
    Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%-10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

    Objectives: To undertake a genome-wide association study (GWAS) to identify genetic predisposing factors for the different clinical phenotypes associated with nevirapine hypersensitivity.

    Methods: A GWAS was undertaken in a discovery cohort of 151 nevirapine-hypersensitive and 182 tolerant, HIV-infected Malawian adults. Read More

    Epidemiology and Molecular Characteristics of Mycoplasma pneumoniae During an Outbreak of M. pneumoniae-Associated Stevens-Johnson Syndrome.
    Pediatr Infect Dis J 2017 Jan 3. Epub 2017 Jan 3.
    1Epidemic Intelligence Service; Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2University of Colorado School of Medicine, Aurora, Colorado, USA 3Centers for Disease Control and Prevention, Atlanta, Georgia, USA 4Children's Hospital Colorado, Aurora, Colorado, USA 5Colorado Department of Public Health and Environment, Denver, CO, USA.
    Background: An increase in Mycoplasma pneumoniae-associated Stevens-Johnson syndrome (SJS) cases at a Colorado pediatric hospital led to an outbreak investigation. We describe the epidemiologic and molecular characteristics of M. pneumoniae among SJS case-patients and surrounding community members during the outbreak. Read More

    Human leukocyte antigen and idiosyncratic adverse drug reactions.
    Drug Metab Pharmacokinet 2017 Feb 18;32(1):21-30. Epub 2016 Nov 18.
    MRC Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, England, UK. Electronic address:
    A clinical association between a specific human leukocyte antigen (HLA) allele and idiosyncratic adverse drug reactions (IADRs) is a strong indication that IADRs are mediated by the adaptive immune system. For example, it is well-established that HLA-B*15:02 and HLA-B*57:01 are associated with carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and abacavir-induced hypersensitivity/flucloxacillin-induced liver injury, respectively. Drug-specific T-cells whose response is restricted by specific HLA risk alleles have been detected from IADR patients, also suggesting an adaptive immune pathogenesis. Read More

    Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis.
    J Invest Dermatol 2016 Dec 20. Epub 2016 Dec 20.
    Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou Keelung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan. Electronic address:
    Early diagnosis and prognosis monitoring for Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) still remain a challenge. This study aims to explore any cytokine/chemokine with prognostic potential in SJS/TEN. Through screening a panel of 28 serological factors, IL-6, IL-8, IL-15, TNF-α, and granulysin were upregulated in SJS/TEN patients and selected for the further validation in total 155 SJS/TEN patients, including 77 from Taiwan and 78 from RegiSCAR (the Registry of Severe Cutaneous Adverse Reactions). Read More

    Erythema exsudativum multiforme induced by a taurine-containing energy drink.
    Acta Dermatovenerol Alp Pannonica Adriat 2016 Dec;25(4):83-84
    Department of Nuclear Medicine, University Clinical Center of Kosovo, Prishtina, Kosovo.
    Erythema exsudativum multiforme is an immunologically mediated skin condition caused by viruses, bacteria, food, and drugs. There are different forms, and depending on the severity of the disease there is a major and minor form. Whereas the minor form passes without consequences, the major form and Stevens-Johnson syndrome affect the mucosa and may result in death. Read More

    Streptococcus agalactiae Endophthalmitis in Boston Keratoprosthesis in a Patient with Steven-Johnson Syndrome.
    Middle East Afr J Ophthalmol 2016 Oct-Dec;23(4):329-331
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
    A 25-year-old Syrian male with a previous episode of Stevens-Johnson syndrome with bilateral corneal cicatrization previously underwent surgery for Type 1 Boston Keratoprosthesis (K-Pro). Sixteen months after the K-Pro surgery, the patient presented with decreased vision to hand motion and microbial keratitis of the graft around the K-Pro with purulent discharge. Corneal scrapings were nonrevealing. Read More

    Effects of hydroxychloroquine on cutaneous lupus erythematosus: A multi-center double-blind randomized parallel-group trial.
    Arthritis Rheumatol 2016 Dec 19. Epub 2016 Dec 19.
    Japanese Hydroxychloroquine Study Group.
    Objectives To assess the efficacy and tolerability of hydroxychloroquine (HCQ) in a phase III clinical trial conducted in Japan Methods A double-blind randomized parallel-group clinical trial was performed. This was a baseline-controlled study and the group differences were evaluated in an exploratory analysis. A total of 103 patients with active CLE (CLASI activity score ≥4) were included. Read More

    Nationwide Survey of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children in the United States.
    Pediatr Dermatol 2016 Dec 19. Epub 2016 Dec 19.
    T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
    Although Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, life-threatening reactions to drug therapies, no efforts have been made to investigate the comprehensive change in epidemiology with respect to age, sex, and race and ethnicity in children. The risk of death was 0.3% to 1. Read More

    Antiepilepsy drugs and the immune system.
    Ann Allergy Asthma Immunol 2016 Dec;117(6):634-640
    Allergy/Immunology Section, Louisiana State University Health Sciences Center, Shreveport, Louisiana. Electronic address:
    Objective: To alert physicians about the peculiar adverse effects of antiepilepsy drugs (AEDs) on the immune system.

    Data Sources: PubMed literature during the past 25 years.

    Study Selections: Reports and review articles on the hypersensitivities of AEDs and their effect on immunity. Read More

    New surgical approach in cases of cataract with ocular Stevens-Johnson syndrome.
    J Cataract Refract Surg 2016 Nov;42(11):1549-1555
    From the Dr. Rajendra Prasad Centre for Ophthalmic Sciences (Sharma, Aron, Venugopal, Titiyal, Agarwal) and the Department of Anatomy (Sangwan), All India Institute of Medical Sciences, New Delhi, India.
    We describe the intraoperative difficulties encountered in cases of ocular Stevens-Johnson syndrome as a result of a poor ocular surface, the presence of symblepharon, and varying degrees of corneal opacity with secondary poor visibility of anterior segment structures. Modifications to the standard phacoemulsification technique enabled safe and successful completion of the surgery in these cases.

    Financial Disclosure: None of the authors has a financial or proprietary interest in any material or method mentioned. Read More

    Russian Keratoprosthesis in Stevens-Johnson Syndrome.
    Cornea 2017 Mar;36(3):304-309
    *Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; †Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China; and ‡Department of Ophthalmology, Rocket Force General Hospital, Beijing, China.
    Purpose: To evaluate the efficacy and safety of Moscow Eye Microsurgery Complex in Russia (MICOF) keratoprosthesis (KPro) implantation in patients with Stevens-Johnson syndrome (SJS).

    Methods: This was a retrospective case series. Fourteen eyes of 13 patients with SJS underwent KPro implantation at the Chinese People's Liberation Army General Hospital between April 1, 2000, and December 24, 2014. Read More

    The cost-effectiveness of HLA-b*5801 screening to guide initial urate-lowering therapy for gout in the United States.
    Semin Arthritis Rheum 2016 Nov 1. Epub 2016 Nov 1.
    Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:
    Objective: Positive HLA-B*5801 carriers are at greater risk of experiencing rare but severe allopurinol hypersensitivity syndrome (AHS) [i.e., Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)]; however, HLA-B*5801 prevalence and AHS risk vary by race/ethnicity. Read More

    Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians.
    Neurology 2017 Jan 2;88(1):78-86. Epub 2016 Dec 2.
    Authors' affiliations are listed at the end of the article.
    Objective: To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese and Thai).

    Methods: We prospectively enrolled patients with OXC-cADRs in Taiwan and Thailand from 2006 to 2014, and analyzed the clinical course, latent period, drug dosage, organ involvement, complications, and mortality. We also investigated the carrier rate of HLA-B*15:02 and HLA-A*31:01 of patients with OXC-cADRs and compared to OXC-tolerant controls. Read More

    The Effect of Intravenous Immunoglobulin Combined with Corticosteroid on the Progression of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Meta-Analysis.
    PLoS One 2016 30;11(11):e0167120. Epub 2016 Nov 30.
    Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
    Background: Intravenous immunoglobulin (IVIG) treatment is commonly used to treat Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with controversial therapeutic effect.

    Methods: We conducted a comprehensive meta-analysis through combining the published eligible studies to evaluate the effectiveness of IVIG on SJS and TEN treatment.

    Results: A total of 26 studies were selected from public available databases. Read More

    [A fixed drug eruption caused by paracetamol].
    Ned Tijdschr Geneeskd 2016 ;160(0):D470
    Huisartsenpraktijk Nederweert, Nederweert.
    Background: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1. Read More

    Stevens-Johnson syndrome in childhood.
    Arch Soc Esp Oftalmol 2016 Nov 26. Epub 2016 Nov 26.
    Servicio de Dermatología, Hospital Infantil Universitario Niño Jesús, Madrid, España.
    Introduction: Stevens-Johnson syndrome and toxic epidermal necrolysis are two serious immune diseases within the context of bullous mucocutaneous syndrome. These have varying degrees of involvement of the skin and usually at least two mucous membranes.

    Clinical Cases: Three clinical cases are presented, two of them with significant ophthalmological sequelae, who had received drug treatment as a possible trigger, and another milder clinical case caused by Mycoplasma pneumoniae. Read More

    Plasma Lipid Profiling of Patients with Chronic Ocular Complications Caused by Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
    PLoS One 2016 29;11(11):e0167402. Epub 2016 Nov 29.
    Division of Medical Safety Science, National Institute of Health Sciences, Setagaya, Tokyo, Japan.
    Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are drug-induced acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface. Even after recovery from skin symptoms, some SJS/TEN patients continue to suffer with severe ocular complications (SOCs). Therefore, this study aims to understand the pathophysiology of chronic SOCs. Read More

    Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population.
    Pharmacol Res 2017 Jan 22;115:168-178. Epub 2016 Nov 22.
    Department of Clinical Pharmacology, La Paz University Hospital-Carlos III, IdiPAZ, School of Medicine, Autonomous University of Madrid, Madrid, Spain. Electronic address:
    Aromatic antiepileptic drugs (AEDs) are among the drugs most frequently involved in severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS). This study investigated the associations between the genetic polymorphisms of HLA class-I and AED-induced SCARs in the Spanish population. HLA class-I genotypes were determined in AED (phenytoin[PHT],lamotrigine[LTG],carbamazepine[CBZ],phenobarbital[PB])-induced SJS/TEN (n=15) or DRESS (n=12) cases included in the Spanish SCAR registry, PIELenRed. Read More

    [Stevens-Johnson syndrome in the dentist practice].
    Stomatologiia (Mosk) 2016;95(5):51-52
    Irkutsk State Medical University, Irkutsk, Russia.
    The article presents a clinical example of the manifestations of Stevens-Johnson syndrome in a young patient. The patient had extensive lesions of the mucosa of the mouth, inflammation of the conjunctiva, itchy skin rashes. Good clinical result was obtained due to the prescribe treatment. Read More

    Validation of Stevens-Johnson syndrome or toxic epidermal necrolysis diagnoses in the Clinical Practice Research Datalink.
    Pharmacoepidemiol Drug Saf 2016 Nov 20. Epub 2016 Nov 20.
    Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
    Purpose: To evaluate the validity of recorded diagnoses of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in the Clinical Practice Research Datalink (CPRD).

    Methods: We identified patients with a diagnosis of SJS or TEN between 1995 and 2013 in the CPRD. We reviewed information from patient records, free text, and hospital episode statistics (HES) data, and excluded patients with no indication of a secondary care referral. Read More

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