6,921 results match your criteria Stevens-Johnson Syndrome


A Novel Real-Time PCR Assay for Detection of HLA-A*31:01 in Individuals Being Considered for Carbamazepine Therapy.

CNS Spectr 2021 Apr;26(2):154-155

Genomind, Inc., King of Prussia, PA, USA.

Background: Carbamazepine, an anticonvulsant also used as a mood stabilizer and for trigeminal neuralgia, is associated with serious, sometimes fatal cutaneous adverse drug reactions, including Stevens Johnson Syndrome and toxic epidermal necrolysis1. Current literature demonstrates a genetic predisposition linked to specific class I and II human leukocyte antigen (HLA) types in various ethnic populations2. HLA-A*31:01 is one such HLA type, and is routinely identified by the tag SNP rs1061235. Read More

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Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Curr Drug Saf 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry-605006, India.

Background And Objective: Identification of the offending drug is crucial and challenging in cases of severe cutaneous adverse drug reactions (CADR) like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Poor reproducibility and varying levels of agreement have been observed among different causality assessment tools (CATs) in assessing severe CADRs. This study was conducted to examine the agreement among four different CATs in assessing cases of drug-induced SJS, TEN and SJS/TEN overlap. Read More

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Dermatologic Toxicities of Targeted Therapy and Immunotherapy in Head and Neck Cancers.

Front Oncol 2021 27;11:605941. Epub 2021 May 27.

Department of Dermatology, City of Hope Los Angeles, Duarte, CA, United States.

Treatment of head and neck cancers requires multidisciplinary collaboration to reduce morbidity and mortality associated with the tumor burden, as well as to preserve function of organs and structures. With the use of various new targeted therapies come new adverse events including dermatologic toxicities, which may consist of xerosis, nail and hair changes, morbilliform or papulopustular rashes, to more severe eruptions such as Stevens-Johnson syndrome. We describe the dermatologic toxicities and corresponding grades of severity and associated pathophysiology resulting from seven therapeutics used to treat head and neck cancers: cetuximab, trastuzumab, pembrolizumab, nivolumab, lentatinib, larotrectinib, and entrectinib. Read More

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Stevens-Johnson syndrome and toxic epidermal necrolysis: a 10-year experience in a burns unit.

J Wound Care 2021 Jun;30(6):492-496

Department of Plastic and Hand Surgery, Burn Unit, Trauma Center Bergmannstrost Halle, Halle, Germany.

Objective: Stevens-Johnson syndrome (SJS) and its more severe counterpart, toxic epidermal necrolysis (TEN), are skin hypersensitivity reactions defined by epidermal blistering and necrosis. The exact pathophysiology of SJS/TEN is yet to be deciphered, but a number of risk factors have been identified including adverse drug reactions. The diagnosis of SJS/TEN is made on a clinical basis, and treatment consists of supportive care and occasionally immunosuppressants, such as cyclosporin, high-dose intravenous immunoglobulins and/or corticosteroids. Read More

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Long-tevrm outcomes of the MICOF keratoprosthesis surgery.

Ocul Surf 2021 Jun 9;21:178-185. Epub 2021 Jun 9.

Department of Ophthalmology, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address:

Purpose: To evaluate long-term anatomical and functional outcomes of the MICOF keratoprosthesis to treat end-stage corneal blindness.

Design: Retrospective review of consecutive clinical case series.

Participants: Between October 2000 and October 2015, at the Department of Ophthalmology of Chinese PLA General Hospital (PLAGH), a total of 132 eyes of 131 patients had undergone a MICOF keratoprosthesis implantation. Read More

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Stevens-Johnson syndrome/toxic epidermal necrolysis induced by pirfenidone.

Indian J Dermatol Venereol Leprol 2021 May 8:1-3. Epub 2021 May 8.

Department of Dermatology Universitario Ramón y Cajal.Madrid, Spain.

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Clinical Characteristics of Patients With Chronic Stevens-Johnson Syndrome Treated at a Major Tertiary Eye Hospital Within the United Kingdom.

Front Med (Lausanne) 2021 24;8:644795. Epub 2021 May 24.

Moorfields Eye Hospital, London, United Kingdom.

The purpose of this study is to provide a comprehensive review of the clinical characteristics in chronic Stevens-Johnson syndrome (SJS) patients within the United Kingdom population, their causative factors, treatment profile and prognosis. This retrospective series included 91 patients with chronic SJS treated at Moorfields Eye Hospital (London, United Kingdom). A chart review included visual acuity and presence of clinical findings (including lid abnormalities and ocular surface findings). Read More

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Physical and Psychological Recovery Following Toxic Epidermal Necrolysis: A Patient Survey.

J Burn Care Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Surgery, University of Washington Medicine UW Medicine Regional Burn Center, Seattle, WA.

Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are acute, life-threatening diseases that cause sloughing of the skin and mucous membranes. Despite improved survival rates, few studies focus on long-term outcomes. We conducted a single-center review of all patients with SJS/TEN admitted from January 2008-2014. Read More

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Lamotrigine and its relationship with Stevens-Johnson syndrome and toxic epidermal necrolysis

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):202-205. Epub 2020 Apr 13.

Secretaría de Salud, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Dermatología, Ciudad de México, México.

Lamotrigine is an antiepileptic drug that has been widely used for epilepsy, as a mood stabilizer (for type 1 bipolar disorder) and in the management of neuropathic pain, it is used both in monotherapy and in complementary therapy. Considered relatively new, approved by the Food and Drug Administration in 1994, its benefits include a greater margin of safety compared to other anticonvulsants. However, although in a lower percentage, it causes severe adverse skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Read More

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Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix.

Clin Ophthalmol 2021 28;15:2231-2238. Epub 2021 May 28.

Corneo-Plastic Unit, Queen Victoria Hospital NHS, East Grinstead, UK.

Objective: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies.

Methods: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen using OmniLenz at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM. Read More

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Lamotrigine and Stevens-Johnson Syndrome Prevention.

Psychopharmacol Bull 2021 Mar;51(2):96-114

Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.

Stevens-Johnson Syndrome (SJS) is a rare life-threatening condition characterized by severe mucocutaneous epidermal necrolysis and detachment of the epidermis. The condition centers around a delayed-type hypersensitivity reaction with a complex etiology stemming from a variety of causes. The number one cause is medication-related-common ones including sulfonamides, antiepileptics, allopurinol, and nonsteroidal anti-inflammatory drugs. Read More

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Cutaneous adverse reactions associated with antiseizure medication: clinical characteristics and implications in epilepsy treatment.

Epileptic Disord 2021 Jun 3. Epub 2021 Jun 3.

Neurology Department, Federal University of Paraná, Curitiba, Brazil.

Objective: To describe the clinical characteristics of cutaneous adverse reactions and cross-sensitivity induced by antiseizure medications and compare the pattern of use of antiseizure medications in patients with epilepsy according to skin rash history.

Methods: We analysed patients with a history of skin rash presenting for up to 12 weeks after initiating antiseizure medication. The history of skin rash was verified by medical charts, interviews, and identification of skin lesions by patients based on illustrative images. Read More

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Neutrophil : lymphocyte ratio is associated with disease severity and mortality in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.

J Dermatol 2021 Jun 1. Epub 2021 Jun 1.

The Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

The neutrophil : lymphocyte ratio (NLR), platelet : lymphocyte ratio (PLR), C-reactive protein : albumin ratio (CAR), and albumin : fibrinogen ratio (AFR) have been considered as useful inflammatory biomarkers. However, their roles in Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) still remain unclear. This study aimed to test whether NLR, PLR, CAR, and AFR serve as predictive markers of disease severity and systemic inflammation in patients with SJS/TEN. Read More

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Toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in pediatric patients with a focus on newer antiepileptic drugs: A 25-year retrospective study at a single tertiary care center.

Pediatr Dermatol 2021 May 31. Epub 2021 May 31.

Department of Dermatology, The University of Texas Medical Branch, Galveston, TX, USA.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis Syndrome (TEN) are rare immune-mediated diseases. Extensive research on adult triggers of SJS and TEN is available; however, research in children is more limited.

Objective: We sought to investigate and report the experience with pediatric SJS and TEN in our center, identifying associated medications. Read More

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Recognition and Management of Severe Cutaneous Adverse Drug Reactions (Including Drug Reaction with Eosinophilia and Systemic Symptoms, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis).

Med Clin North Am 2021 Jul;105(4):577-597

Division of Dermatology, Department of Medicine, 3810 Springhurst Boulevard, Suite 200, Louisville, KY 40241, USA.

Severe cutaneous adverse reactions to medications (SCARs) include drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis. They are all non-immunoglobulin E mediated hypersensitivity reaction patterns, distinguished from simple cutaneous drug eruptions by immunologic pathogenesis and internal organ involvement. Herein the clinical features, diagnostic workup, and management considerations are presented for each of these major SCARs. Read More

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Regulation of innate immune response by miR-628-3p upregulated in the plasma of Stevens-Johnson syndrome patients.

Ocul Surf 2021 May 28;21:174-177. Epub 2021 May 28.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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Clinical Aspects of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis With Severe Ocular Complications in Taiwan.

Front Med (Lausanne) 2021 12;8:661891. Epub 2021 May 12.

Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Over the last decade, there has been tremendous progress in the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). To understand whether this has resulted in better ophthalmic outcomes, we aimed to study the incidence of severe ocular complications (SOCs) in the acute and chronic stage among SJS/TEN patients, major causative medications, and therapeutic effect of medical and surgical treatment. Using electronic medical records review of patients of Chang Gung Memorial Hospital Linkou Branch from 2010 to 2020, 119 patients (236 eyes) received ophthalmic consultation during the acute stage and were retrospectively studied. Read More

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Limbal Stem Cell Deficiency: Demographics and Clinical Characteristics of a Large Retrospective Series at a Single Tertiary Referral Center.

Cornea 2021 May 27. Epub 2021 May 27.

Virginia Eye Consultants, Norfolk, VA; Ospedale Oftalmico di Torino, Ospedale San Giovanni Bosco, Turin, Italy; Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH; and Virginia Eye Center, Lansdowne, VA.

Purpose: The aim of this study was to characterize a large cohort of patients presenting to a single referral center for limbal stem cell deficiency (LSCD).

Methods: A retrospective chart review of all patients with a clinical diagnosis of LSCD from 2002 to 2015 was performed. Demographics, etiology, previous ocular surgeries, visual acuity, and treatment were assessed. Read More

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T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab.

J Immunother Cancer 2021 May;9(5)

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK

Many adverse reactions associated with immune checkpoint inhibitor (ICI) treatments are immunologically driven and may necessitate discontinuation of the ICI. Herein, we present a patient who had been administered the radio contrast media amidotrizoate multiple times without issue but who then developed a Stevens-Johnson syndrome reaction after coadministration of atezolizumab. Causality was confirmed by a positive re-challenge with amidotrizoate and laboratory investigations that implicated T cells. Read More

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Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus: two cases report.

Pan Afr Med J 2021 4;38:236. Epub 2021 Mar 4.

Dermatology and Venereology Department, Mohammed V University, Rabat, Morocco.

Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus (TEN-like ACLE) is a rare manifestation of systemic lupus erythematosus (SLE). Because of its rarity, little is known about this entity. In this report, we describe a case of two women previously diagnosed with SLE that presented TEN-like skin lesions. Read More

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Vulvovaginal involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis: management and techniques used to reduce gynecologic sequelae.

Int J Dermatol 2021 May 26. Epub 2021 May 26.

Division of Urogynecology, Department of Obstetrics and Gynecology, UC Irvine Medical Center, Orange, CA, USA.

Background: Vulvovaginal involvement in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is common, likely underdiagnosed, and can result in severe sequelae if not managed acutely. There are few studies on acute management of vulvovaginal SJS/TEN. Current recommendations are predominantly based on expert opinion. Read More

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The Ocular Microbiome in Stevens-Johnson Syndrome.

Front Med (Lausanne) 2021 7;8:645053. Epub 2021 May 7.

Excellence Center for Cornea and Limbal Stem Cell Transplantation, Department of Ophthalmology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.

The ocular surface microbiome is an essential factor that maintains ocular surface homeostasis. Since the ocular surface is continuously exposed to the external environment, its microbiome, tears, and local immunity are vital for maintaining normal conditions. Additionally, this microbiome helps prevent pathogen colonization, which commonly leads to opportunistic infection. Read More

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Prevalence of Clinical Spectrum of Cutaneous Adverse Drug Reactions in Patients Presenting at a Tertiary Care Hospital in Pakistan.

Cureus 2021 Apr 19;13(4):e14568. Epub 2021 Apr 19.

Biostatistics and Epidemiology, Aga Khan University Hospital, Karachi, PAK.

Introduction: Cutaneous adverse drug reactions (CADRs) are the most common adverse drug reactions reported in the literature. CADRs have resulted in disabling infirmities during hospitalization and complications following outdoor drug therapy. The pattern of CADRs and the responsible drugs usually changes with the introduction of newer drugs and evolving clinical practices. Read More

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Stevens Johnson Syndrome in Children: Consider Monitoring for Bronchiolitis Obliterans.

J Pediatr 2021 May 19. Epub 2021 May 19.

Department of Pediatrics, University of Colorado School of Medicine; The Breathing Institute, Children's Hospital Colorado.

We reviewed patients with Stevens Johnson Syndrome (SJS) evaluated at Children's Hospital Colorado and investigated the occurrence of bronchiolitis obliterans (BO). Approximately 9% of patients with SJS developed BO. Pediatricians should consider monitoring patients with SJS for BO, especially those with recurrent SJS and patients treated with mechanical ventilation. Read More

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A pediatric case of Stevens-Johnson syndrome with acute liver failure, resulting in liver transplantation.

J Dermatol 2021 May 21. Epub 2021 May 21.

Department of Dermatology, Yokohama City University School of Medicine, Yokohama, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse skin reactions characterized by high fever, epidermal detachment, and mucositis. It is well known that SJS/TEN occasionally affects various organs, leading to permanent damage and death in some patients. Although acute liver dysfunction is a relatively common complication of SJS/TEN, severe acute liver dysfunction requiring liver transplantation is rare. Read More

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Stevens-Johnson syndrome induced by tonic water.

J Eur Acad Dermatol Venereol 2021 May 20. Epub 2021 May 20.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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A case of bortezomib (Velcade)-induced Stevens-Johnson syndrome confirmed by patch test.

Asia Pac Allergy 2021 Apr 21;11(2):e17. Epub 2021 Apr 21.

Department of Internal Medicine, Kosin University Gospel Hospital, Busan, Korea.

Bortezomib, a highly selective reversible inhibitor of the proteasome complex, is used to the current standard of care in the treatment of multiple myeloma. Although its most commonly reported side effects are gastrointestinal symptoms, peripheral neuropathy, neuropathic pain, and thrombocytopenia, cutaneous adverse reactions are also frequently seen. However, severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS) occur very rarely. Read More

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Long-term outcome of cultivated oral mucosal epithelial transplantation for fornix reconstruction in chronic cicatrising diseases.

Br J Ophthalmol 2021 May 18. Epub 2021 May 18.

Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan

Background/aims: To investigate the long-term outcomes of cultivated oral mucosal epithelial transplantation (COMET) for fornix reconstruction in eyes with chronic cicatrising disease.

Methods: This retrospective cohort study involved 16 eyes of 15 patients who underwent COMET for symblepharon release and fornix reconstruction between June 2002 and December 2008. The mean postoperative follow-up period was 102. Read More

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A novel diagnostic technique of measuring labial minor salivary gland secretions using sodium fluorescein dye: Implications for patients with dry eyes.

Semin Ophthalmol 2021 May 16:1-6. Epub 2021 May 16.

Center for Ocular Regeneration (CORE), L V Prasad Eye Institute, Hyderabad, Telangana, India.

: To evaluate the lower labial minor salivary glands (MSGs) flow rate using fluorescein dye in healthy individuals and patients with Sjögren's syndrome (SS) and Stevens-Johnson syndrome (SJS).: Thirty consecutive patients with SS ( = 15; mean age 35.7 years) and SJS ( = 15; 57. Read More

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Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing .

Front Immunol 2021 29;12:658593. Epub 2021 Apr 29.

Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

-positive patients in Thailand can develop frequent co-trimoxazole hypersensitivity reactions. This study aimed to characterize drug-specific T cells from three co-trimoxazole hypersensitive patients presenting with either Stevens-Johnson syndrome or drug reaction with eosinophilia and systemic symptoms. Two of the patients carried the HLA allele of interest, namely . Read More

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