6,236 results match your criteria Stevens-Johnson Syndrome


Expression of prostaglandin E receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background/aims: In a previous genome-wide association study of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients we reported the association between SJS/TEN and the prostaglandin E receptor 3 (PTGER3) gene, and that its protein PGE receptor 3 (EP3) was markedly downregulated in the conjunctival epithelium of SJS/TEN patients. Here we examined EP3 expression of the eyelid epidermis in SJS/TEN patients with severe ocular complications and investigated the function of EP3.

Methods: For the immunohistochemical study, we obtained eyelid samples from five SJS/TEN patients and five patients without SJS/TEN (control subjects) who were undergoing surgery to treat trichiasis, and investigated the expression of EP3 protein in the epidermis of those samples. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313587DOI Listing

Microbial Keratitis in Stevens-Johnson Syndrome: A Prospective Study.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the microbiological profile and outcome in cases with infective keratitis in Stevens-Johnson syndrome (SJS).

Methods: Eighty-three eyes of 68 patients with SJS presenting with microbial keratitis were recruited and managed with standard antimicrobial therapy.

Results: Microbial keratitis developed in 34% of patients with SJS (83 eyes, 68 patients) over a period of 5 years. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001960DOI Listing
April 2019
1 Read

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
2 Reads

[Cutaneous Adverse Drug Reaction Caused by Antiepileptic Drug].

Brain Nerve 2019 Apr;71(4):401-406

Department of Dermatology, Niigata University Graduate School of Medical and Dental Sciences.

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug induced hypersensitivity syndrome (DIHS) are severe cutaneous adverse reactions, which can be life-threatening and lead to severe sequelae. Antiepileptic drugs frequently cause severe adverse reactions in the form of. It is important to understand the characteristics of each disease and attempt at early diagnosis. Read More

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https://webview.isho.jp/journal/detail/abs/10.11477/mf.14162
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http://dx.doi.org/10.11477/mf.1416201284DOI Listing
April 2019
2 Reads

Toxic epidermal necrolysis after acute burn injury.

Ann Burns Fire Disasters 2018 Dec;31(4):266-270

National Burns Unit, Saint James' Hospital, Dublin, Republic of Ireland.

Toxic epidermal necrolysis is a rare, potentially fatal disorder that involves large areas of skin desquamation. Patients with toxic epidermal necrolysis are frequently referred to burn centres for expert wound management and early comprehensive critical care as this has been shown to improve patient outcome and mortality. The authors describe the first report of medication-induced toxic epidermal necrolysis occurring in a patient during acute burn management in a tertiary burn care facility. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441584PMC
December 2018
2 Reads

Twelve years of Lyell's Syndrome in the burn unit of São João Hospital Centre.

Ann Burns Fire Disasters 2018 Dec;31(4):259-265

Plastic Surgery and Burns Unit, Centro Hospitalar São João, Porto, Portugal.

Stevens-Johnson syndrome (SSJ) and toxic epidermal necrolysis (TEN) correspond to an acute and rare life-threatening mucocutaneous reaction. We describe the etiology, length of stay, comorbidities and mortality of TEN in our hospital in a retrospective study of 12 years. Twenty-one patients were included in the study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441583PMC
December 2018

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

Am J Hum Genet 2019 Apr 10. Epub 2019 Apr 10.

Molecular Neurosciences, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK. Electronic address:

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193010
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http://dx.doi.org/10.1016/j.ajhg.2019.03.005DOI Listing
April 2019
5 Reads

The rash that presents as target lesions.

Clin Dermatol 2019 Mar - Apr;37(2):148-158. Epub 2018 Dec 5.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

We have explored the rash that appears as target lesions, with the central and dominant diseases belonging to the Stevens-Johnson syndrome/toxic epidermal necrolysis group. After presenting the clinical patterns of an individual target lesion and classifying them into different types of lesions, the contribution has been organized with groups characterized by such specific findings according to the type of lesion: flat or raised, typical or atypical, presence or absence of fever, presence or absence of mucosal ulcerations, presence or absence of arthralgias, and/or internal organ involvement. Other specific features, such as histologic appearance, immunofluorescence findings, and laboratory changes, are considered. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183025
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http://dx.doi.org/10.1016/j.clindermatol.2018.12.008DOI Listing
December 2018
2 Reads

FR-Ciclosporin as a First-Line Treatment in Epidermal Necrolysis.

Actas Dermosifiliogr 2019 Apr 7. Epub 2019 Apr 7.

Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00017310183044
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http://dx.doi.org/10.1016/j.ad.2018.01.014DOI Listing
April 2019
3 Reads

Liver involvement in the drug reaction, eosinophilia, and systemic symptoms syndrome.

World J Clin Cases 2019 Mar;7(6):705-716

Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, Alberta T2N 4Z6, Canada.

First described in 1996, the drug reaction, eosinophilia, and systemic symptoms syndrome (DReSS) is considered, along with Stevens-Johnson syndrome and toxic epidermal necrolysis, a severe cutaneous drug reaction. It is characterized by the presence of a maculopapular erythematous skin eruption, fever, lymphadenopathy, influenza-like symptoms, eosinophilia, and visceral involvement such as hepatitis, pneumonitis, myocarditis, pericarditis, nephritis, and colitis. The prognosis of patients with DReSS is related to the severity of visceral involvement. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i6.705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448072PMC
March 2019
2 Reads

[Anti-laminin 332 mucous membrane pemphigoid with irreversible ocular and tracheobronchial involvement : Delayed diagnosis of a severe autoimmune bullous disease].

Hautarzt 2019 Apr 8. Epub 2019 Apr 8.

Klinik für Dermatologie, Allergologie und Venerologie, Universität Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

A 53-year-old man presented with a 37-year history of erosive and scarring mucosal lesions of several organs. An initial diagnosis of Stevens-Johnson syndrome was maintained for many years. Due to late correct diagnosis of an anti-laminin 332 mucous membrane pemphigoid and the fact that early, targeted, intensified immunosuppressive therapy was not initiated, the disease led to almost complete loss of vision and obstruction of airways. Read More

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http://dx.doi.org/10.1007/s00105-019-4402-zDOI Listing
April 2019
1 Read

Making Rash Decisions in Epilepsy: Evaluating Hypersensitivity Reactions to Anti-seizure Medications.

Epilepsy Curr 2019 Mar-Apr;19(2):96-98

The Frequency and Clinical Features of Hypersensitivity Reactions to Antiepileptic Drugs in Children: A Prospective Study Guvenir H, Dibek Misirlioglu E, Civelek E. J Allergy Clin Immunol Pract. 2018;6(6):2043-2050. Read More

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http://dx.doi.org/10.1177/1535759719835672DOI Listing
April 2019
1 Read

A Case of Stevens-Johnson Syndrome After Exposure to Valproic Acid.

Prim Care Companion CNS Disord 2019 Mar 28;21(2). Epub 2019 Mar 28.

Department of Psychiatry, Weill Cornell Medicine, 407 E 61st St, New York, New York 10065.

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http://dx.doi.org/10.4088/PCC.18l02374DOI Listing
March 2019
2 Reads

Mucosal Lichen Planus Mimicking Mucosal Lesions in Stevens-Johnson Syndrome after Nivolumab Therapy.

Acta Derm Venereol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Nara Medical University, Nara 634-8522, Japan.

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http://dx.doi.org/10.2340/00015555-3185DOI Listing
April 2019
3 Reads

Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement.

Eur J Clin Pharmacol 2019 Mar 27. Epub 2019 Mar 27.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

Purpose: Establishment of causality between drug exposure and adverse drug reactions (ADR) is challenging even for serious ADRs such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Several causality assessment tools (CAT) exist, but the reliability and validity of such tools is variable. The objective of this study was to compare the reliability and validity of existing ADR CATs on SJS/TEN cases. Read More

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http://link.springer.com/10.1007/s00228-019-02670-9
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http://dx.doi.org/10.1007/s00228-019-02670-9DOI Listing
March 2019
3 Reads
2.966 Impact Factor

Spontaneous cutaneous adverse drug reaction reports-An analysis of a 10-year dataset in Singapore.

Pharmacol Res Perspect 2019 04 13;7(2):e00469. Epub 2019 Mar 13.

Department of Pharmacy Faculty of Science National University of Singapore Singapore Singapore.

We analyzed the spontaneous adverse event database in Singapore to determine the types of cutaneous adverse drug reactions (CADRs) and causative drugs reported. We selected 10 CADRs-of-interest, and identified the suspected drugs and the characteristics of the at-risk population. ADR reports received from 2006 to 2015 of the system organ class "Skin and Appendages Disorders" were analyzed based on patient demographics, the types of CADRs, suspected drugs, outcome, and latency period. Read More

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http://dx.doi.org/10.1002/prp2.469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415979PMC
April 2019
2 Reads

Bronchiolitis Obliterans as long-term sequela of non-drug related Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in children.

Clin Exp Dermatol 2019 Mar 25. Epub 2019 Mar 25.

University Hospital Southampton NHS Foundation Trust, Department of Dermatology, Southampton, UK.

Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are characterised by widespread skin and mucosal necrosis and are infrequently reported in children. Triggers and long-term sequelae differ to those reported for adult cases. Bronchiolitis obliterans (BO) is a rarely reported complication but is associated with significant long-term morbidity. Read More

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http://dx.doi.org/10.1111/ced.13969DOI Listing
March 2019
1 Read

A 10-year retrospective cohort study of the management of toxic epidermal necrolysis and Stevens-Johnson syndrome in a New South Wales state referral hospital from 2006 to 2016.

Int J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Concord Repatriation General Hospital, The Sydney University, Concord Clinical School Concord, Concord, New South Wales, Australia.

Importance: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening severe cutaneous drug reactions. There have been no Australian data published since 2007.

Objective: To explore whether there is an association between prognosis and the type of systemic immune-modulation treatment administered in a cohort of patients with SJS, SJS-TEN overlap, and TEN at the New South Wales State SJS/TEN referral center - Concord Repatriation General Hospital. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14426
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http://dx.doi.org/10.1111/ijd.14426DOI Listing
March 2019
4 Reads

HLA-associated antiepileptic drug-induced cutaneous adverse reactions.

HLA 2019 Mar 20. Epub 2019 Mar 20.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

Adverse drug reactions (ADRs) are a common cause of hospital admissions (up to 19%), with the majority of cases due to off-target predictable drug effects (type A reactions). However, idiosyncratic drug-induced immune activated (type B) reactions contribute to a range of hypersensitivity reactions, with T-cell-mediated type IV hypersensitivity reactions mainly manifesting as cutaneous ADRs (cADRs). Aromatic antiepileptic drugs (AEDs), used in the treatment of epilepsy as well as bipolar disorder or neuropathic pain, have been implicated as culprit drugs in a spectrum of pathologies ranging from mild maculopapular exanthema (MPE) to severe and life-threatening conditions including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Read More

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http://dx.doi.org/10.1111/tan.13530DOI Listing
March 2019
1 Read

Sutureless amniotic membrane transplantation with cyanoacrylate glue for acute Stevens-Johnson syndrome/toxic epidermal necrolysis.

Ocul Surf 2019 Mar 11. Epub 2019 Mar 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. Electronic address:

Amniotic membrane (AM) transplantation, when performed in the acute phase in Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) for patients with ocular complications, is known to reduce the morbidity of ocular complications in the chronic phase. In conditions such as SJS/TEN, AM needs to be secured to the ocular surface as well as the eyelids. Previously, techniques of securing a large sheet of AM with fibrin glue to the ocular surface and with sutures and bolsters to the eyelids have been described in the acute phase of SJS/TEN. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.03.001DOI Listing
March 2019
3 Reads

Ciprofloxacin-induced Stevens-Johnson Syndrome with Grapefruit Juice Consumption: A Case Report.

Cureus 2019 Jan 4;11(1):e3827. Epub 2019 Jan 4.

Dermatology, University of Arizona College of Medicine, Tucson, USA.

We describe the case of a 49-year-old, otherwise healthy, Hispanic male who underwent an uncomplicated vasectomy and was treated prophylactically with a one-week course of ciprofloxacin. Two days after completing the antibiotic course, he developed a pruritic, blistering rash that covered 90% of his body surface area. Punch biopsy of the skin lesions confirmed the diagnosis of Stevens-Johnson syndrome (SJS). Read More

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http://dx.doi.org/10.7759/cureus.3827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402866PMC
January 2019
1 Read

A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine.

Methods Mol Biol 2019 ;1939:181-198

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

In the era of big data and informatics, computational integration of data across the hierarchical structures of human biology enables discovery of new druggable targets of disease and new mode of action of a drug. We present herein a computational framework and guide of integrating drug targets, gene expression data, transcription factors, and prior knowledge of protein interactions to computationally construct the signaling network (mode of action) of a drug. In a similar manner, a disease network is constructed using its disease targets. Read More

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http://link.springer.com/10.1007/978-1-4939-9089-4_10
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http://dx.doi.org/10.1007/978-1-4939-9089-4_10DOI Listing
January 2019
6 Reads

Development and Validation of a Risk Prediction Model for In-Hospital Mortality Among Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis-ABCD-10.

JAMA Dermatol 2019 Mar 6. Epub 2019 Mar 6.

Department of Dermatology, University of Pennsylvania, Philadelphia.

Importance: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of severe mucocutaneous drug reaction associated with significant morbidity and mortality. A previously developed SJS/TEN-specific severity-of-illness model (Score of Toxic Epidermal Necrolysis [SCORTEN]) has been reported to overestimate and underestimate SJS/TEN-related in-hospital mortality in various populations.

Objective: To derive a risk prediction model for in-hospital mortality among patients with SJS/TEN and to compare prognostic accuracy with the SCORTEN model in a multi-institutional cohort of patients in the United States. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.5605DOI Listing
March 2019
11 Reads

Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo.

Dermatol Res Pract 2019 30;2019:4917024. Epub 2019 Jan 30.

Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, Togo.

Aim: The aim of this study was to assess ocular and mucocutaneous sequelae among SJS/TEN survivors and identify risk factors of ocular sequelae.

Patients And Method: Late complications among SJS/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retrospective assessment of medical records and physical examination of survivors who were contacted by phone.

Results: Between January 1995 and December 2017, 177 cases of SJS/TEN (138 cases of SJS, 29 cases of TEN, and 10 cases SJS/TEN overlap) were admitted into two university hospitals of Lomé (Togo). Read More

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http://dx.doi.org/10.1155/2019/4917024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374872PMC
January 2019
2 Reads

Pediatric toxic epidermal necrolysis treated successfully with infliximab.

Pediatr Dermatol 2019 Mar 4. Epub 2019 Mar 4.

Departments of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Read More

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http://dx.doi.org/10.1111/pde.13778DOI Listing
March 2019
2 Reads

Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

Acta Biomed 2019 Jan 29;90(3-S):52-60. Epub 2019 Jan 29.

Department of Pediatrics, Senigallia Hospital, Senigallia, Italy.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be considered a late-onset allergic reaction, can cause serious long-term sequelae. SJS/TEN are considered a spectrum of life-threatening adverse drug reactions. They have the same clinical manifestations and the only difference is in the extent of epidermal detachment. Read More

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http://dx.doi.org/10.23750/abm.v90i3-S.8165DOI Listing
January 2019
1 Read

British Association of Dermatologists guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in children and young people 2018.

Br J Dermatol 2019 Mar 4. Epub 2019 Mar 4.

Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, U.K.

The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in children (0-12) and young people (13-17) during the acute phase of the disease. The document aims to: offer an appraisal of all relevant literature up to July 2018, focusing on any key developments. address important, practical clinical questions relating to the primary guideline objective. Read More

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http://dx.doi.org/10.1111/bjd.17841DOI Listing
March 2019
8 Reads

Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian population.

Seizure 2019 Mar 20;66:99-103. Epub 2019 Feb 20.

All India Institute of Medical Sciences, Neurology, Neurosciences Centre, Room no-705, 7th floor, 110029, New Delhi, India. Electronic address:

Purpose: Aromatic antiepileptic drugs (AEDs) are frequently implicated in cutaneous adverse drug reactions (cADRs), a few of which are associated with certain human leukocyte antigen (HLA) alleles in some populations. We aimed to find HLA-associations with AED-related cADRs among North Indians.

Methods: North Indian subjects with cADR due to an AED, and those who were AED-tolerant were recruited as cases and controls, respectively. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.011DOI Listing
March 2019
9 Reads

Stevens-Johnson syndrome and toxic epidermal necrolysis: retrospective review of 10-year experience.

Int J Dermatol 2019 Mar 1. Epub 2019 Mar 1.

Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous disorders. To date, relatively few studies have looked at institutional approaches to treatment of SJS/TEN, particularly with a focus on wound care.

Methods: A retrospective review was conducted on patients admitted to the Hennepin County Medical Center from 2007 to 2017 with a final diagnosis of SJS or TEN. Read More

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http://dx.doi.org/10.1111/ijd.14409DOI Listing
March 2019
1 Read

Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies.

Int J Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacy Practice, JSS College of Pharmacy, Jagadguru Shri Shivarathreeshwara University, Mysuru, Karnataka, India.

Valproic acid (VPA) is a commonly used antiepileptic drug (AED). Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are the rare but fatal cutaneous adverse drug reactions for VPA. We aimed to identify and critically evaluate all the literature of SJS in association with VPA and to describe the clinical features of the condition. Read More

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http://dx.doi.org/10.1111/ijd.14411DOI Listing
February 2019
3 Reads

Spectrum of gastrointestinal involvement in Stevens - Johnson syndrome.

World J Gastrointest Endosc 2019 Feb;11(2):115-123

Health Center, National Institute of Technology, Patna 800014, India.

Stevens - Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with involvement of skin and mucosal membranes, and carries significant risk of mortality and morbidity. Mucus membrane lesions usually involve the oral cavity, lips, bulbar conjunctiva and the anogenitalia. The oral/anal mucosa and liver are commonly involved in SJS or TEN. Read More

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http://dx.doi.org/10.4253/wjge.v11.i2.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379748PMC
February 2019

Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Dermatology, Saint Louis University, St Louis, Missouri (Dr Abate);the Departments of Dermatology (Dr Battle),and Pathology (Drs Gardner and Shalin),University of Arkansas for Medical Sciences, Little Rock; and the Department of Dermatology, University of Mississippi Medical Center, Jackson (Dr Emerson).

Context.—: Fatal dermatologic diseases and ones with high morbidity can occur in the inpatient setting. In such cases, prompt and accurate assessment of a bedside skin biopsy is required. Read More

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http://dx.doi.org/10.5858/arpa.2018-0239-RADOI Listing
February 2019
2 Reads

Late-onset Stevens-Johnson syndrome due to nivolumab use for hepatocellular carcinoma.

J Oncol Pharm Pract 2019 Feb 19:1078155219830166. Epub 2019 Feb 19.

1 Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage, CA, USA.

Nivolumab is a fully human immunoglobulin G4 immune checkpoint inhibitor antibody approved for use in the treatment of several malignancies. Severe side effects such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have only extremely rarely been reported with this drug. We present herein a patient who developed SJS after 16 weeks of therapy with nivolumab. Read More

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http://dx.doi.org/10.1177/1078155219830166DOI Listing
February 2019
4 Reads

[Fatal Toxic Epidermal Necrolysis Induced by Diclofenac Re-Administration in the Teaching Hospital of Bouaké (Côte d'Ivoire)].

Bull Soc Pathol Exot 2018 ;111(1):9-11

Service d'anesthésie-réanimation, CHU de Bouaké, BP 1174 Bouaké, Côte d'Ivoire.

Lyell's syndrome or toxic epidermal necrolysis is an acute and severe cutaneous adverse drug reaction with a significant morbidity and mortality. It is a very rare condition but a vital emergency with a poor prognosis. The diagnosis is clinical and confirmed by a cutaneous biopsy showing a necrosis of the epidermis. Read More

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http://dx.doi.org/10.3166/bspe-2018-0009DOI Listing
January 2018

Intravenous immunoglobulin treatment: Where do dermatologists stand?

Authors:
Selma Emre

Dermatol Ther 2019 Feb 13:e12854. Epub 2019 Feb 13.

Department of Dermatology, Yildirim Beyazit University, Medical School, Ankara, Turkey.

Intravenous immunoglobulins (IVIG) are therapeutic products, comprising polyclonal IgGs, which are obtained from human plasma pool of healthy blood donors. Despite the lack of Food and Drug Administration (FDA) approval, the experience of using IVIG in various dermatological diseases increases day by day and exciting results are reported. However, experience with the use of IVIG in dermatological indications are mostly case reports whereas randomized, controlled, double-blind, multicentric studies have not been performed. Read More

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http://dx.doi.org/10.1111/dth.12854DOI Listing
February 2019
5 Reads

Bullous Pemphigoid-like Skin Eruption during Treatment with Rivaroxaban: A Clinical Case Study.

Eur J Case Rep Intern Med 2018 21;5(3):000724. Epub 2018 Mar 21.

Serviço de Anatomia Patológica, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

Little has been documented about hypersensitivity reactions caused by treatment with rivaroxaban. This paper reports a bullous pemphigoid-like skin eruption that occurred in a 76-year-old female patient during rivaroxaban treatment. This case highlights the vigilance required by healthcare workers in recognising potential adverse effects of newly marketed drugs and in making medication changes when necessary. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/724
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http://dx.doi.org/10.12890/2018_000724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346955PMC
March 2018
3 Reads

-associated Mucositis: A Recently Described Entity.

Eur J Case Rep Intern Med 2018 28;5(11):000977. Epub 2018 Nov 28.

Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.

(MP) is a common cause of respiratory infections and can be associated with extrapulmonary complications. MP mucositis has recently been described as a distinct endemic clinical entity called e-induced rash and mucositis (MIRM). The authors present the case of a 46-year-old man with atypical pneumonia associated with exuberant mucositis, conjunctival hyperaemia and positive serological assays for MP IgM. Read More

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http://dx.doi.org/10.12890/2018_000977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346809PMC
November 2018
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Ocular Surface Reconstruction Using Circumferentially-trephined Autologous Oral Mucosal Graft Transplantation in Limbal Stem Cell Deficiency.

Korean J Ophthalmol 2019 Feb;33(1):16-25

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To investigate the effects of transplantation of a circumferentially-trephined autologous oral mucosal graft using a vacuum trephine on ocular surface reconstruction in patients with limbal stem cell deficiency.

Methods: Patients with a limbal stem cell deficiency who underwent transplantation of autologous oral mucosal graft performed by a particular surgeon in Seoul National University Hospital were included. The medical records of these five patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.3341/kjo.2018.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372385PMC
February 2019
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Bronchiolitis Obliterans After Cefuroxime-Induced Stevens-Johnson Syndrome.

Am J Case Rep 2019 Feb 9;20:171-174. Epub 2019 Feb 9.

Department of Inernal Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

BACKGROUND Bronchiolitis obliterans is the term used to describe a clinical syndrome of irreversible airflow obstruction. Among the etiologies linked to this entity is the rarely reported association with Stevens-Johnson syndrome, which has had a poor outcome in most of the previously published cases. The optimum management of bronchiolitis obliterans as a complication of Stevens-Johnson syndrome is not well defined. Read More

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http://dx.doi.org/10.12659/AJCR.913723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380208PMC
February 2019
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Multi-Step Grading System for Evaluation of Chronic Ocular Sequelae in Patients with Stevens-Johnson Syndrome.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Vision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre, University of Melbourne, Australia.

Purpose: To propose a new scoring system for grading of chronic ocular sequelae in Stevens-Johnson syndrome (SJS).

Design: Reliability and validity analysis PARTICIPANTS: Four hundred eyes of 200 patients with chronic ocular SJS/TEN were included in the study.

Settings: Single centre, tertiary eye care referral centre METHODS: All patients of SJS/TEN with chronic (more than one year) ocular sequelae were recruited for the study. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.028DOI Listing
February 2019
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Docetaxel-Induced Stevens-Johnson Syndrome in a Patient with Metastatic Prostate Adenocarcinoma.

Case Rep Oncol Med 2019 8;2019:7928752. Epub 2019 Jan 8.

Department of Medicine, Creighton University, Omaha, NE, USA.

Docetaxel is a commonly used chemotherapeutic agent in a variety of cancer treatment regimens. We present a case of apparent docetaxel-induced Stevens-Johnson syndrome (SJS) in a patient recently treated for metastatic prostate cancer. This medication is not classically associated with the development of SJS but in our case, along with a number of other case reports, and a single phase II clinical trial, an association was recognized. Read More

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http://dx.doi.org/10.1155/2019/7928752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341237PMC
January 2019
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Epidermal necrolysis: SCORTEN performance in AIDS and non-AIDS patients.

An Bras Dermatol 2019 Jan-Feb;94(1):17-23

Division of Dermatology, Department of Internal Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa (PR), Brazil.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening blistering drug reactions with high incidence of ocular sequela. The term 'Epidermal Necrolysis' has been recently used to better describe the full spectrum of the disease that includes Stevens-Johnson syndrome and toxic epidermal necrolysis at opposite ends, which differ by the extent of body surface area with epidermal detachment. SCORTEN is a mortality prognosis score for 'Epidermal Necrolysis' cases that still needed validation in acquired immunodeficiency syndrome. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20196864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360969PMC
February 2019
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Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population.

Br J Ophthalmol 2019 Apr 31;103(4):573-576. Epub 2019 Jan 31.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Background/aims: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313263DOI Listing
April 2019
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Biologic TNF-alpha inhibitors in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: a systemic review.

J Dermatolog Treat 2019 Jan 31:1-8. Epub 2019 Jan 31.

a Department of Dermatology, First Affiliated Hospital , College of Medicine, Zhejiang University , Hangzhou , China.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) is one of severe cutaneous adverse reactions with low morbidity but high mortality. Different systemic immunomodulating treatments are proposed but still remain controversial. Tumor necrosis factor (TNF)-alpha is long thought to be a vital mediator of epithelial cell death in SJS-TEN, indicating a potential target for therapy. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1577548DOI Listing
January 2019
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A Review of the Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Adv Emerg Nurs J 2019 Jan/Mar;41(1):56-64

Department of Pharmacy Services, University of Kentucky HealthCare, Lexington.

Stevens-Johnson syndrome and toxic epidermal necrolysis represent a spectrum of severe cutaneous adverse reactions that carry the potential for severe, long-term adverse effects, including death. Although medications are most commonly implicated in the development of these diseases, other factors, including infection and genetics, play a role. Management is generally supportive in nature and includes maintenance of the patient's airway, breathing, and circulation. Read More

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http://dx.doi.org/10.1097/TME.0000000000000225DOI Listing
February 2019
4 Reads

Adverse Cutaneous Drug Reactions Associated with Old- and New- Generation Antiepileptic Drugs Using the Japanese Pharmacovigilance Database.

Clin Drug Investig 2019 Apr;39(4):363-368

Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.

Background And Objective: Adverse cutaneous drug reactions associated with antiepileptic drugs (AEDs) are a serious problem in the clinical setting. New-generation AEDs have been reported to be better tolerated than old-generation forms; however, information about the risks of adverse cutaneous drug reactions to new-generation AEDs is limited.

Objective: The purpose of this study was to clarify the association of AEDs with adverse cutaneous drug reactions using a spontaneous reporting database. Read More

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http://dx.doi.org/10.1007/s40261-019-00754-zDOI Listing

Interventions for erythema multiforme: a systematic review.

J Eur Acad Dermatol Venereol 2019 Jan 25. Epub 2019 Jan 25.

Service de Dermatologie, AP-HP, Hôpital Henri Mondor, Créteil, France.

Treatment of erythema multiforme (EM) is not codified. We performed a systematic review of the effect of any topical or systemic treatment on time to healing and frequency of episodes with acute and chronic forms of EM in adults. Four databases (MEDLINE, CENTRAL, EMBASE and LILACS) and other sources were searched for articles published up to 20 March 2018. Read More

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http://dx.doi.org/10.1111/jdv.15447DOI Listing
January 2019
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Stevens - Johnson syndrome (SJS) following Murunga leaf (Moringa oleifera) consumption

Ceylon Med J 2018 12;63(4):188-189

Base Hospital, Deniyaya, Sri Lanka.

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http://dx.doi.org/10.4038/cmj.v63i4.8771DOI Listing
December 2018
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Analysis of Individual Case Safety Reports of Severe Cutaneous Adverse Reactions in Korea.

Yonsei Med J 2019 Feb;60(2):208-215

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Purpose: Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea.

Materials And Methods: We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting System from 1988 to 2013. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.2.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342723PMC
February 2019
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Prosthetic Replacement of the Ocular Surface Ecosystem Treatment for Ocular Surface Disease in Pediatric Patients with Stevens-Johnson Syndrome.

Am J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: To report the outcomes of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment in pediatric patients with chronic ocular surface disease associated with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).

Design: Retrospective, interventional case series METHODS: Patients ages 18 or younger seen in consultation for PROSE treatment at a single center between January 1992 and December 2016 with a history of SJS/TEN were reviewed. Demographics, etiology of SJS/TEN, age at treatment milestones, best corrected visual acuity (BCVA) at treatment milestones and treatment failures were recorded. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.006DOI Listing
January 2019
4 Reads