6,590 results match your criteria Stevens-Johnson Syndrome


Positive patch testing with omeprazole in Stevens-Johnson syndrome: a case report.

J Eur Acad Dermatol Venereol 2020 Jul 11. Epub 2020 Jul 11.

Department of Dermatology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life threatening cutaneous reactions, caused by a delayed-type hypersensitivity reaction to medication1. Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide with a large proportion of non-evidence based applications2. A 69-year-old man, known with arterial hypertension and gout, was started on 64mg methylprednisolone for a chronic inflammatory demyelinating polyneuropathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16814DOI Listing

Anti-MDA-5 Dermatomyositis With Development of Drug-Mediated Necrolytic Skin Lesions.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620940496

University of Florida, Gainesville, FL, USA.

A 59-year-old male presented with 1 month of progressive dyspnea, 30-lb weight loss, and skin changes on the digits of the hands. In the 4 weeks prior to admission, he was admitted and treated twice for pneumonia at another hospital and received intravenous (IV) vancomycin, ceftriaxone, and azithromycin for a total of 10 days. After admission, he underwent computed tomography imaging of chest, which revealed findings suggestive of interstitial lung disease but given the fact that infection was not ruled out, empiric antibiotics were initiated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2324709620940496DOI Listing

Single-cell RNA analysis: guiding the treatment of DiHS/DRESS.

Allergy 2020 Jul 7. Epub 2020 Jul 7.

Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.

Drug-induced hypersensitivity syndrome (DiHS) ─also termed as drug reaction with eosinophilia and systemic symptoms (DRESS)─ is a potentially lethal inflammatory disease associated with human herpesvirus (HHV) reactivation. DiHS/DRESS is classified within a group of syndromes named severe cutaneous adverse reactions (SCARs), including acute generalized exanthematous pustulosis and Stevens-Johnson syndrome/toxic epidermal necrolysis. SCARs are delayed type IV hypersensitivity reactions mainly characterized by T-cell activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14487DOI Listing

Reconstruction of microstomia considering their functional status.

Arch Craniofac Surg 2020 Jun 29;21(3):161-165. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Inha University Hospital, Incheon, Korea.

Background: Microstomia is defined as a condition with a small sized-mouth that results in functional impairment such as difficulty with food intake, pronunciation, and poor oral hygiene and cosmetic problems. Several treatment methods for microstomia have been proposed. None of them are universally applicable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7181/acfs.2020.00220DOI Listing

Hydroxychloroquine-induced Stevens-Johnson syndrome in COVID-19: a rare case report.

Oxf Med Case Reports 2020 Jun 25;2020(6):omaa042. Epub 2020 Jun 25.

Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

The international outbreak of respiratory illness termed coronavirus disease 2019 (COVID-19) began in December 2019 that has affected >0.8 million individuals. Self-limiting respiratory tract involvement, severe pneumonia, multiorgan failure and death are the spectrum of COVID-19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/omcr/omaa042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315925PMC

Intravenous -acetylcysteine in severe cutaneous drug reaction treatment: A case series.

SAGE Open Med Case Rep 2020 20;8:2050313X20934708. Epub 2020 Jun 20.

Department of Internal Medicine and ICU, Square Hospitals Ltd., Dhaka, Bangladesh.

Drug-induced serious adverse reaction is an unpleasant event with high rate of mortality. Stevens-Johnson Syndrome and toxic epidermal necrolysis are most common among the serious adverse drug reactions. There is no selective drug therapy for the management of serious adverse drug reactions-associated mucocutaneous blisters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050313X20934708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307482PMC

Corrigendum: Thiotepa hyperpigmentation preceding epidermal necrosis: malignant intertrigo misdiagnosed as Stevens-Johnson syndrome-toxic epidermal necrolysis overlap.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Cedars Dermatology, Cedars Sinai Medical Group, CA.

The original article was published on February 15, 2020 and corrected on March 15, 2020.The revised version of the article corrects the contact information of the Corresponding Author. The changes appear in the revised online PDF copy of this article. Read More

View Article

Download full-text PDF

Source

Plasma Rich in Growth Factors for the Treatment of Cicatrizing Conjunctivitis.

Clin Ophthalmol 2020 17;14:1619-1627. Epub 2020 Jun 17.

Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, Oviedo, Spain.

Purpose: The objective was to evaluate the clinical results obtained from the use of immunosafe plasma rich in growth factors (isPRGF) in the treatment of patients with cicatrizing conjunctivitis (CC) who had not responded to the usual therapy.

Patients And Methods: This is a retrospective study that included patients diagnosed with CC, in whom isPRGF was used in different phases (I: eye drops; II: eye drops and injectable; III: eye drops, injectable and surgical treatment) to achieve control of the inflammation. As a clinical follow-up of the patients, the better corrected visual acuity (BCVA), degree of inflammation (measured from 1 to 4), the severity of the CC, Schirmer I test, IOP and TBUT were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OPTH.S252253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306461PMC

HLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis.

Sci Rep 2020 Jun 29;10(1):10589. Epub 2020 Jun 29.

Center of Excellence for Environmental Health and Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand.

Serious cutaneous adverse drug reactions [i.e., SJS/TEN with severe ocular complications (SOC)] associated with cold medicine (CM) were reported in several studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67610-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324363PMC
June 2020
5.078 Impact Factor

Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency.

Ocul Surf 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Japan; Cornea Center Eye Bank, Tokyo Dental College, Ichikawa General Hospital, Japan; Department of Ophthalmology, Keio University School of Medicine, Japan.

Purpose: This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation (CCST), and to clarify risk factors that affected the outcomes.

Methods: We retrospectively analyzed the medical charts and photographs of 246 consecutive surgeries (162 eyes from 139 patients) that used CCST for treating total limbal stem cell deficiency. Deficiency types included Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN; n = 80), ocular surface burns (Burn; n = 75), ocular cicatricial pemphigoid (OCP) or pseudo-OCP (n = 58), and others (n = 33). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtos.2020.06.005DOI Listing

Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis.

F1000Res 2020 16;9. Epub 2020 Jun 16.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases characterized by detachment of the epidermis and mucous membrane. SJS/TEN are considered to be on the same spectrum of diseases with different severities. They are classified by the percentage of skin detachment area. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.24748.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308994PMC

Mycoplasma pneumoniae-associated Stevens-Johnson syndrome: Characteristic histological features of mucosal lesion.

J Eur Acad Dermatol Venereol 2020 Jun 28. Epub 2020 Jun 28.

Division of Dermatology, Niigata University, Graduate School of Medicine and Dental Sciences.

Mycoplasma pneumoniae induces various skin conditions, potentially characterized by the development of extensive mucosal/eye lesions consistent with Stevens-Johnson syndrome (SJS). Particularly, in cases of pediatric SJS, M. pneumoniae infections are a major etiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16796DOI Listing

Ocular management of acute Stevens-Johnson syndrome in a 14-month-old child.

Can J Ophthalmol 2020 Jun 24. Epub 2020 Jun 24.

University of Utah Moran Eye Center, Salt Lake City, UT.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2020.05.006DOI Listing

Labial mucosa grafting for lid margin, anterior lamellar, and posterior lamellar correction in recurrent cicatricial entropion.

Orbit 2020 Jun 25:1-5. Epub 2020 Jun 25.

Ophthalmic Plastic Surgery Services, LJ Eye Institute , Ambala, India.

Purpose: To report a novel modified technique for severe recurrent cicatricial entropion correction based on anterior lamellar recession (ALR) and grafting.

Methods: Six eyelids of five patients (9-48 years; three females) with severe cicatricial entropion (three upper and three lower eyelids) had surgical correction using ALR and labial mucosal grafting for spacing the ciliary margin away from the lid margin and reconstruction of the lid margin and posterior lamella. The modified technique included using mucous membrane as a single unit for anterior lamella, lid margin, and posterior lamella reconstruction employing a different suturing technique. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01676830.2020.1782439DOI Listing

Safety of BRAF+MEK Inhibitor Combinations: Severe Adverse Event Evaluation.

Cancers (Basel) 2020 Jun 22;12(6). Epub 2020 Jun 22.

Ella Lemelbaum Institute for Immuno-oncology, Sheba Medical Center, Ramat-Gan 526260, Israel.

The selective BRAF and MEK inhibitors (BRAFi+MEKi) have substantially improved the survival of melanoma patients with BRAF V600 mutations. However, BRAFi+MEKi can also cause severe or fatal outcomes. We aimed to identify and compare serious adverse events (sAEs) that are significantly associated with BRAFi+MEKi. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12061650DOI Listing

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children With Non-Hodgkin Lymphoma.

J Pediatr Hematol Oncol 2020 Jul;42(5):e310-e314

Departments of Pediatric Hematology and Oncology.

The aim of this study is to evaluate the clinical and laboratory findings of pediatric patients with non-Hodgkin lymphoma (NHL) who developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Between 2006 and 2018, the medical records of child patients with NHL who developed SJS and TEN were reviewed retrospectively. SJS/TEN developed in 7 of 70 patients with NHL (10%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPH.0000000000001851DOI Listing

Mycoplasma Pneumoniae Induced Rash and Mucositis (MIRM): A Longitudinal Perspective and Proposed Management Criteria.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

Purpose: To evaluate the natural history and ophthalmologic morbidity of Mycoplasma pneumoniae induced rash and mucositis (MIRM) and propose a treatment algorithm.

Design: Retrospective, interventional case series METHODS: Retrospective chart review of all MIRM patients examined by the department of ophthalmology at a tertiary children's hospital. Diagnosis was established clinically concomitant with either positive Mycoplasma pneumoniae IgM or PCR testing from January 1 2010 until December 31 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2020.06.010DOI Listing

Stevens-Johnson Syndrome Secondary to Doxycycline Treatment in a Teenage Boy.

Actas Dermosifiliogr 2020 Jun 20. Epub 2020 Jun 20.

Servicio de Dermatología, Hospital Sant Joan de Déu, Barcelona, España. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ad.2019.02.021DOI Listing

Acute pancreatic injuries: A complication of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with cytotoxic immune cell activation.

J Am Acad Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. Electronic address:

Background: Complications involving internal organs are usually present in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, pancreatic complications are rarely reported and studied.

Objective: To summarize clinical characteristics of SJS/TEN-associated acute pancreatic injuries (API) and to investigate underlying inflammatory mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.06.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297678PMC

Two cases of Vici syndrome presenting with corpus callosum agenesis, albinism, and severe developmental delay.

Turk J Pediatr 2020 ;62(3):474-478

Divisions of Pediatric Nutrition and Metabolism, Hacettepe University Faculty of Medicine, Ankara.

Background: Vici syndrome is a rare autosomal recessive disease with phenotypically heterogeneous presentation. Characteristic features of the disease are oculocutaneous albinism, corpus callosum agenesis, cataract, cardiomyopathy, and immunodeficiency.

Case: Here we report two Turkish patients with Vici syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24953/turkjped.2020.03.015DOI Listing
January 2020

Stevens-Johnson syndrome triggered by Levetiracetam-Caution for use with Carbamazepine.

Seizure 2020 Jun 8;80:63-64. Epub 2020 Jun 8.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2020.06.004DOI Listing

Traditional and advanced therapeutic modalities for wounds in the paediatric population: an evidence-based review.

J Wound Care 2020 Jun;29(6):321-334

University of Miami Miller School of Medicine, Dr. Phillip Frost Dermatology and Cutaneous Surgery, 1321 NW 14th Street, Suite 506, Miami, FL 33125, US.

Objective: Children can have non-healing wounds due to a wide range of pathologies, including epidermolysis bullosa (EB), pilonidal disease and Stevens-Johnson syndrome, with some causes being iatrogenic, including extravasation injuries and medical device-related hospital-acquired pressure ulcers. Furthermore, paediatric wounds are vastly different from adult wounds and therefore require a different treatment approach. While there are numerous types of dressings, topical remedies, and matrices with high-tier evidence to support their use in adults, evidence is scarce in the neonatal and paediatric age groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/jowc.2020.29.6.321DOI Listing

Multidisciplinary care in Stevens-Johnson syndrome.

Ther Adv Chronic Dis 2020 28;11:2040622319894469. Epub 2020 Apr 28.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA.

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are potentially fatal mucocutaneous diseases that can involve many organ systems. Manifestations of SJS/TEN outside of the skin, eyes, and oral mucosa are not well defined or well recognized, and, therefore, are often not addressed clinically. As supportive care improves and mortality from SJS/TEN decreases, chronic complications in affected organ systems are becoming more prevalent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2040622319894469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236394PMC

The Association Between Concurrence of Infection and the Onset of Severe Eruption or Liver Injury in Patients Using Antipyretic Analgesics: A Matched, Nested Case-Control Study.

J Clin Pharmacol 2020 Jun 10. Epub 2020 Jun 10.

Division of Medicinal Safety Science, National Institute of Health Sciences, Kanagawa, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) or drug-induced liver injury (DILI) are severe drug-induced reactions, known as idiosyncratic drug reactions. It is believed that immune response can lead to these severe adverse drug reactions. Our previous analysis of the Japanese Spontaneous Drug Reaction database suggested that the onset of SJS/TEN and DILI was strongly associated with infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.1613DOI Listing

General characteristics, economic burden, causative drugs and medical errors associated with medical damage litigation involving severe cutaneous adverse drug reactions in China.

J Clin Pharm Ther 2020 Jun 9. Epub 2020 Jun 9.

Hemopurification Center, Division of Nursing, Tongde Hospital of Zhejiang Province, Hangzhou, China.

What Is Known And Objective: To investigate the general characteristics, economic burden, causative drugs and medical errors associated with litigation involving severe cutaneous adverse drug reactions (SCADRs) in China, with the aims of improving rational medication use and reducing the extent of damage from SCADRs.

Methods: This study analysed 150 lawsuit judgements involving SCADRs from 2005 to 2019, collected from China Judgments Online.

Results And Discussion: In total, 50% of lawsuits stemmed from SCADRs occurring in general hospitals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpt.13174DOI Listing

Clinical trial to evaluate the therapeutic benefits of limbal-supported contact lens wear for ocular sequelae due to Stevens-Johnson syndrome/toxic epidermal necrolysis.

Cont Lens Anterior Eye 2020 Jun 5. Epub 2020 Jun 5.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramach-dori, Kamigyo-ku, Kyoto 602-0841, Japan. Electronic address:

Purpose: To analyze the therapeutic benefits of limbal-supported contact lens (CL) wear in patients with ocular sequelae due to Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN).

Methods: This interventional study enrolled 10 chronic SJS/TEN eyes with a spectacle best-corrected visual acuity (BCVA) of between 0.01 and 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clae.2020.05.007DOI Listing

An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.

Expert Opin Drug Metab Toxicol 2020 Jun 8. Epub 2020 Jun 8.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital , Linkou, Taipei, and Keelung, Taiwan.

Introduction: Phenytoin is a frequently used drug treatment for epilepsy. Genetic polymorphisms in the metabolism of phenytoin, particularly , are strongly associated with increased plasma concentrations and can result in toxicity. Human leukocyte antigen () alleles are well-known genetic predictors of certain antiepileptic drug-associated severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17425255.2020.1780209DOI Listing

A pediatric case of Stevens-Johnson syndrome/toxic epidermal necrolysis with rapid response to intravenous cyclosporine.

JAAD Case Rep 2020 Jun 7;6(6):555-557. Epub 2020 May 7.

Division of Dermatology, McGill University Health Center-Glen site, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265061PMC

Burn center admissions of patients with autoimmune rheumatic diseases: clinical characteristics and outcomes.

Rheumatol Int 2020 Jun 8. Epub 2020 Jun 8.

Department of Surgery, Valleywise Health, Phoenix, AZ, USA.

The ojective of this study was to describe the reasons for admission to the burn center of patients with autoimmune rheumatic diseases (ARD), identify their clinical characteristics, and assess their outcomes relative to the non-ARD patients. We conducted a retrospective study of ARD patients admitted to a burn center from 2011 to 2018, and they were compared with a non-ARD group of patients. Medical records were reviewed for patients' clinical characteristics, including demographics, ARD diagnosis, laboratory studies, and APACHE II score. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-020-04617-1DOI Listing

Differences in treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis at burn centers and non-burn centers.

J Burn Care Res 2020 Jun 4. Epub 2020 Jun 4.

Hennepin County Medical Center.

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome (SJS/TEN) are severe exfoliative skin disorders resulting primarily from allergic drug reactions and sometimes from viral causes. Because of the significant epidermal loss in many of these patients, many of them end up receiving treatment at a burn center for expertise in the care of large wounds. Previous work on the treatment of this disease focused only on the differences in care of the same patients treated at non-burn centers and then transferred to burn centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jbcr/iraa082DOI Listing

Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.

J Dtsch Dermatol Ges 2020 Jun 29;18(6):547-553. Epub 2020 May 29.

Department of Dermatology and Venereology, University Medical Center, Rostock, Germany.

Prior to the first international consensus classification published in 1993, the clinical distinction between erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had been subject to uncertainty and controversy for more than a century. Based on this classification, the three conditions are defined by the morphology of the individual lesions and their pattern of distribution. Etiopathogenetically, the majority of EM cases is caused by infections (primarily herpes simplex virus and Mycoplasma pneumoniae), whereas SJS/TEN are predominantly triggered by drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.14118DOI Listing

Usage Pattern of Carbamazepine and Associated Severe Cutaneous Adverse Reactions in Singapore Following Implementation of Genotyping as Standard-of-Care.

Front Pharmacol 2020 7;11:527. Epub 2020 May 7.

Vigilance and Compliance Branch, Health Products Regulation Group, Health Sciences Authority, Singapore, Singapore.

In April 2013, the Ministry of Health and Health Sciences Authority of Singapore jointly issued recommendations for genotyping before starting carbamazepine (CBZ) in new patients of Asian ancestry as standard of care. The Ministry of Health also approved a 75% subsidy for genotyping to all patients on subsidy at public healthcare institutions. To understand the impact of these regulatory decisions, we researched the usage patterns for CBZ and levetiracetam, the trend of Stevens-Johnson syndrome/toxic epidermal necrolysis [Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)] reports associated with antiepileptic drugs and the take-up rates of tests in Singapore. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2020.00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221117PMC

Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).

Cureus 2020 May 19;12(5):e8198. Epub 2020 May 19.

Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, USA.

The recent outbreak of COVID-19 has put significant strain on the current health system and has exposed dangers previously overlooked. The pathogen known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is notable for attacking the pulmonary system causing acute respiratory distress, but it can also severely affect other systems in at-risk individuals including cardiovascular compromise, gastrointestinal distress, acute kidney injury, coagulopathies, cutaneous manifestations, and ultimately death from multi-organ failure. Unfortunately, the reliability of negative test results is questionable and the high infectious burden of the virus calls for extended safety precautions, especially in symptomatic patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243064PMC

CME Part II: Immune checkpoint inhibitor-related dermatologic adverse events.

J Am Acad Dermatol 2020 May 23. Epub 2020 May 23.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Weill Cornell Medicine, New York, NY. Electronic address:

Immune checkpoint inhibitors (CPI) have emerged as a pillar in the management of advanced malignancies. However, nonspecific immune activation may lead to immune-related adverse events (irAEs), wherein the skin and its appendages are the most frequent targets. Cutaneous irAEs (irCAEs) include a diverse group of inflammatory reactions, with maculopapular rash (MPR), pruritus, and lichenoid dermatitis being the most prevalent subtypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.03.132DOI Listing

Genetic association of co-trimoxazole-induced severe cutaneous adverse reactions is phenotype-specific: HLA class I genotypes and haplotypes.

Clin Pharmacol Ther 2020 May 26. Epub 2020 May 26.

Department of Molecular and Clinical Pharmacology, The Royal Liverpool, Broadgreen University Hospitals NHS Trust, MRC Centre for Drug Safety Science, Liverpool Health Partners, University of Liverpool, Liverpool, UK.

Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case-control study was conducted to investigate the involvement between genetic variants of human leukocyte antigen (HLA) and CYP2C9 in CTX-induced SCARs, including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) in Thai patients. Thirty cases of CTX-induced SCARs were enrolled and compared with 91 CTX-tolerant controls and 150 general Thai population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1915DOI Listing

The effects of systemic cyclosporine in acute Stevens-Johnson syndrome/toxic epidermal necrolysis on ocular disease.

Ocul Surf 2020 May 20. Epub 2020 May 20.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:

Purpose: To evaluate the effect of systemic cyclosporine (CsA) on ocular disease in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients.

Methods: In this retrospective, comparative cohort study at a single center, patients with a diagnosis of SJS/TEN and with at least 3 months of follow up were divided into two groups: those who received systemic CsA and those who did not receive systemic CsA. Best-corrected visual acuity (BCVA) and chronic ocular surface complications score (COCS) at final follow-up were compared between the two groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtos.2020.05.003DOI Listing

TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis.

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620926800

Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, China.

Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753466620926800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243041PMC

Treatment of Oculoplastic and Ocular Surface Disease in Eyes Implanted with a Type I Boston Keratoprosthesis in Southern China: A Retrospective Study.

Adv Ther 2020 Jul 20;37(7):3206-3222. Epub 2020 May 20.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.

Introduction: This study aimed to describe the clinical features, surgical management of the eyelid and ocular surface, and outcomes of 16 patients implanted with a Boston type I keratoprosthesis (KPro).

Methods: A retrospective, single-center, consecutive case series of 16 patients with Stevens-Johnson syndrome (1), ocular chemical burns (12), and ocular thermal burns (3) implanted with KPro was studied. All subjects were men aged 27-51 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12325-020-01381-3DOI Listing

[European Guidelines (S1) on the use of high-dose intravenous immunoglobulin in dermatology].

Hautarzt 2020 Jul;71(7):542-552

Hautklinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.

Background And Objectives: Treatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high-dose intravenous immunoglobulin (IVIg) is a well-established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe cases, the use of immunoglobulin is not generally based on data from randomized controlled trials usually required for evidence-based medicine. Since the indications for the use of IVIg are rare, it is unlikely that such studies will be available in the foreseeable future. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00105-020-04610-6DOI Listing

Direct Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease.

Ophthalmic Plast Reconstr Surg 2020 May 15. Epub 2020 May 15.

University of Michigan Medical School, Ann Arbor, Michigan.

Purpose: Conjunctival cicatrizing conditions are vision threatening, with poor outcomes despite aggressive systemic therapy. This study tests the utility of serial injections of 5-fluorouracil (5-FU) into the fornices to treat conjunctival scarring in patients with ocular cicatricial pemphigoid or Stevens-Johnson syndrome/toxic epidermal necrolysis.

Methods: Retrospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IOP.0000000000001717DOI Listing

Clinical and pathogenic aspects of the severe cutaneous adverse reaction epidermal necrolysis (EN).

J Eur Acad Dermatol Venereol 2020 Mar 12. Epub 2020 Mar 12.

Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.

The severe cutaneous adverse reaction epidermal necrolysis (EN) which includes toxic epidermal necrolysis and the milder Stevens-Johnson syndrome is characterized by epidermal loss due to massive keratinocyte apoptosis and/or necroptosis. EN is often caused by a drug mediating a specific TCR-HLA interaction via the (pro)hapten, pharmacological interaction or altered peptide loading mechanism involving a self-peptide presented by keratinocytes. (Memory) CD8 + T cells are activated and exhibit cytotoxicity against keratinocytes via the perforin/granzyme B and granulysin pathway and Fas/FasL interaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16339DOI Listing

Ventilatory support in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis.

J Dermatolog Treat 2020 May 28:1-6. Epub 2020 May 28.

Sydney Medical School, University of Sydney, Sydney, Australia.

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are blistering cutaneous disorders that often manifest with epidermal and mucosal necrosis. In extreme cases, the upper or bronchial airways are threatened, necessitating intubation and mechanical ventilation. This systematic review and meta-analysis examines the prevalence of mechanical ventilation (MV) in patients with SJS or TENS, despite maximal medical therapy, and additionally aims to identify the risk factors associated with this requirement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2020.1770173DOI Listing
May 2020
1.764 Impact Factor

Stevens Johnson Syndrome in a Patient with Giant Cell Arteritis During Short Term Tocilizumab Therapy.

Cureus 2020 Apr 13;12(4):e7662. Epub 2020 Apr 13.

Allergy and Immunology, Rutgers New Jersey Medical School, Newark, USA.

This case report represents a rare life-threatening hypersensitivity reaction of tocilizumab drug when it is used to treat giant cell arteritis. An elderly female with history of bilateral giant cell arteritis with anterior ischemic optic neuropathy of the right eye was started on tocilizumab after developing glucocorticoid-related complications. She received one month of the tocilizumab therapy along with the prednisone taper. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219013PMC

Toxic epidermal necrolysis syndrome induced by tigecycline: a case report.

J Int Med Res 2020 May;48(5):300060520922416

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.

A 56-year-old man diagnosed with non-Hodgkin's lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060520922416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223212PMC

Readmission Risk Factors and Complications in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Cureus 2020 Apr 11;12(4):e7631. Epub 2020 Apr 11.

Internal Medicine, University of Louisville, Louisville, USA.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous hypersensitivity reactions that cause necrosis of the epidermis, often at multiple sites. This process is frequently caused by medications and is associated with significant complications and mortality during hospitalization. However, increasing attention has been drawn to the less studied area of post-hospitalization complications leading to multiple readmissions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213658PMC

Bullous pemphigoid secondary to pembrolizumab mimicking toxic epidermal necrolysis.

JAAD Case Rep 2020 May 29;6(5):400-402. Epub 2020 Apr 29.

Department of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2020.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200194PMC

Early surgical correction of microstomia following Stevens-Johnson syndrome.

Arch Craniofac Surg 2020 Apr 20;21(2):119-122. Epub 2020 Apr 20.

Department of Plastic and Reconstructive Surgery, Inha University Hospital, Incheon, Korea.

Stevens-Johnson syndrome (SJS) is a rare disease in which extensive toxic epidermolysis occurs after medication. Skin and mucous membranes are involved in about 90% of SJS cases, and webbing of mouth corners (microstomia) may occur when they are affected. Few reports have been issued on microstomia in SJS, and no consensus has been reached regarding treatment methods, timings, or results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7181/acfs.2019.00759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206467PMC

Erythema Multiforme Versus Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Subtle Difference in Presentation, Major Difference in Management.

Mil Med 2020 May 6. Epub 2020 May 6.

Department of Dermatology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda MD 20889.

Erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis are immune-mediated epidermal conditions with variable clinical presentations. Although their clinical presentations often overlap, they have distinct etiologies and potential outcomes, which necessitate specific management strategies. This case is presented to highlight the subtle differences and review management given that Stevens-Johnson syndrome/toxic epidermal necrolysis can rapidly become life-threatening. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/milmed/usaa029DOI Listing

Comparison of Signal Detection Algorithms Based on Frequency Statistical Model for Drug-Drug Interaction Using Spontaneous Reporting Systems.

Pharm Res 2020 Apr 30;37(5):86. Epub 2020 Apr 30.

Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1196, Japan.

Purpose: Adverse events (AEs) caused by polypharmacy have recently become a clinical problem, and it is important to monitor the safety profile of drug-drug interactions (DDIs). Mining signals using the spontaneous reporting systems is a very effective method for single drug-induced AE monitoring as well as early detection of DDIs. The objective of this study was to compare signal detection algorithms for DDIs based on frequency statistical models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-020-02801-3DOI Listing

Stevens-Johnson Syndrome and Herpes Simplex Type 1 Infection during Adalimumab Therapy for Crohn's Disease.

Case Rep Gastrointest Med 2020 15;2020:3875024. Epub 2020 Apr 15.

Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.

Stevens-Johnson syndrome (SJS) is a severe mucocutaneous adverse drug reaction with a relatively high mortality rate. SJS is described during herpes simplex virus type 1 (HSV1) infection and, rarely, even during adalimumab therapy. We report the case of a patient with Crohn's disease who developed SJS during an HSV1 infection and a contemporaneous anti-TNF therapy with adalimumab. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3875024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180430PMC