6,986 results match your criteria Steroids[Journal]


Effect of testosterone cypionate and stanozolol on the heart of young trained mice: a morphometric study.

Steroids 2019 Feb 14. Epub 2019 Feb 14.

Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil. Electronic address:

Testosterone cypionate and Stanozolol are Anabolic-Androgenic Steroids (AAS) which are synthetic substances that possess functions similar to testosterone. The use of these substances has increased considerably among youngsters and sports practitioners aiming better performance of with aesthetic purposes. The major concern is the effects caused by the inappropriate use of the substances, such as hypertension, myocardial ischemia, and left ventricle hypertrophy. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.011DOI Listing
February 2019

Immunomodulatory effects of progesterone and selective ligands of membrane progesterone receptors.

Steroids 2019 Feb 9. Epub 2019 Feb 9.

Faculty of Biology, Lomonosov Moscow State University, Moscow, 119991 Russia. Electronic address:

Progesterone (P4) and its analogues regulate various reproductive processes, such as ovulation, implantation, pregnancy maintenance and delivery. In these processes, an important role is played by the immune cells recruited to the female reproductive organs and tissues, where they are exposed to the action of P4. Progestins regulate cellular processes, acting through nuclear steroid receptors (nSRs), membrane P4 receptors (mPRs), and through the sensors. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.009DOI Listing
February 2019

Biotransformation into 11α-hydroxyprogesterone glucosides by glucosyltransferase.

Steroids 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea; Genome-based BioIT Convergence Institute, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea; Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea. Electronic address:

Recently, studies on the steroidal hormone activity in the brain have attracted attention, and the influences of the varied glucosides and their artificial derivatives have been discussed; additionally, it has been suggested that glucosides are the synthetic precursors of glucuronide as a label molecule. However, glucosides are formed with 11α-hydroxyprogesterone (1), which is important as a blood pressure regulator, but anti-androgen activity remains unknown. Using UDP-glucosyltransferase, glucoside synthesis was successful in linking β--glucopyranose and β--laminaribiose to 11α oxygen of 1 at a high conversion ratio, and full assignment structure was analyzed for the two glucosides by high-resolution quadrupole-time flight electrospray ionization-mass spectrometry, 1D (H and C) NMR and 2D (COSY, ROESY, HSQC-DEPT and HMQC) NMR. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.008DOI Listing
February 2019

Severe forms of complete androgen insensitivity syndrome caused by a p.Q65X novel mutation in androgen receptor: clinical manifestations, imaging findings and molecular genetics.

Steroids 2019 Feb 8. Epub 2019 Feb 8.

Children Inherited Metabolism and Endocrine Department, Guangdong Women and Children Hospital, No. 521 XingNan Road, Panyu District, Guangzhou, Guangdong 511400, P.R.China.

Androgen insensitivity syndrome (AIS), a rare X-linked recessive genetic disorder with a normal 46, XY karyotype, is caused by defect of androgen receptor gene (AR) leading to resistance of the target tissues to androgenic hormones. There is a wide spectrum of clinical presentations of AIS, ranging from male infertility, hypospadias to completely normal female external genitalia. Here, we describe a 15-year old, phenotypically female individual, who visited our clinic for primary amenorrhea. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.007DOI Listing
February 2019
1 Read

Induced Production of Steroids by Co-Cultivation of Two Endophytes from Mahonia fortunei.

Steroids 2019 Feb 6. Epub 2019 Feb 6.

Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China; Department of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, People's Republic of China. Electronic address:

A new ergosterol derivative, 23R-hydroxy-(20Z,24R)-ergosta-4,6,8(14),20(22)-tetraen-3-one (1), and a biosynthetically related known compound, (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (2), were isolated from the co-culture between endophytic fungus Pleosporales sp. F46 and endophytic bacterium Bacillus wiedmannii Com1 both inhibiting in the medicinal plant Mahonia fortunei. The structure of the new compound 1 was determined by extensive spectroscopic analysis using HRMS and NMR, together with the modified Mosher's ester method. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.005DOI Listing
February 2019
1 Read

Synthesis of benzoylbenzamide derivatives of 17α-E-vinyl estradiol and evaluation as ligands for the estrogen receptor-α ligand binding domain.

Steroids 2019 Feb 6;144:15-20. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, United States.

A series consisting of substituted benzoylbenzamide derivatives of 17α-E-vinyl estradiol 6a-i and 7a-d was prepared in good overall yields from the corresponding novel iodinated benzoylbenzamide precursors using Pd(0)-catalyzed Stille coupling. Biological evaluation using competitive binding assays indicated that all compounds were effective ligands for the ERα- and ERβ-LBD (RBA = 0.5-10. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.003DOI Listing
February 2019

Review of fluorescent steroidal ligands for the estrogen receptor 1995-2018.

Steroids 2019 Feb 6;144:30-46. Epub 2019 Feb 6.

Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston MA02115-5000, United States. Electronic address:

The development of fluorescent ligands for the estrogen receptor (ER) continues to be of interest. Over the past 20 years, most efforts have focused on appending an expanding variety of fluorophores to the B-, C- and D-rings of the steroidal scaffold. This review highlights the synthesis and evaluation of derivatives substituted primarily at the 6-, 7α- and 17α-positions, culminating with our recent work on 11β-substituted estradiols, and proposes an approach to new fluorescent imaging agents that retain high ER affinity. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.002DOI Listing
February 2019

Sex differences in glucocorticoids-induced anabolic effects on energy balance.

Steroids 2019 Feb 6. Epub 2019 Feb 6.

Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil. Electronic address:

Glucocorticoids (GC) increase food intake and body weight in humans and rodents, and chronic stress and GC treatment-induced enhancement on plasma concentration of GC leads to obesity and metabolic changes. In response to hypercaloric treatment, males were shown to be more susceptible to obesity compared to females, demonstrating that intersexual differences may affect energy homeostasis. The objective of the current study was to evaluate the effects of prolonged (28 days) treatment with dexamethasone or corticosterone in intact rats, both male and female, on food intake, body weight gain, Lee index, weights and area of adipocytes of retroperitoneal and perigonadal+perirenal adipose tissues, glucose tolerance test (GTT) and plasma concentrations of free fatty acids, cholesterol and triglycerides. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X193002
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http://dx.doi.org/10.1016/j.steroids.2019.02.006DOI Listing
February 2019
3 Reads

Synthesis of steroidal 1,2- and 1,3-diamines as ligands for transition metal ion complexation.

Steroids 2019 Feb 6. Epub 2019 Feb 6.

Institute of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland.

Two series of cholestane-based diamines (1,2 and 1,3) were synthesized using simple and efficient procedures. The convenient substrates for these syntheses were cholesteryl mesylate and tosylate, which were converted to appropriate amines via easily obtained azides. The final diamines were prepared using a substitution reaction with bromoacetonitrile (in the case of 1,2-diamines) or condensation with acrylonitrile (in the case of 1,3-diamines), followed by the reduction of intermediate aminonitriles. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.001DOI Listing
February 2019

Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain.

Steroids 2019 Feb 6;144:21-29. Epub 2019 Feb 6.

Institute for Maternal and Child Research (IDIMI), School of Medicine, University of Chile, Avenida Santa Rosa 1234, 8360160 Santiago-Centro, Santiago, Chile; Department of Obstetrics and Gynecology, School of Medicine, San Borja-Arriaran Clinical Hospital, University of Chile, Avenida Santa Rosa 1234, 8360160 Santiago-Centro, Santiago, Chile. Electronic address:

An estradiol metabolite, 2-methoxyestradiol (2ME), has emerged as an important regulator of ovarian physiology. 2ME is recognized as a potent anti-angiogenic agent in clinical trials and laboratory studies. However, little is known about its molecular actions and its endogenous targets. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.004DOI Listing
February 2019

Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.

Steroids 2019 Jan 29. Epub 2019 Jan 29.

Laboratory of Experimental Endocrinology, University of Crete, School of Medicine, Heraklion 71013, Greece. Electronic address:

Accumulating evidence during the last decades revealed that androgens exert membrane-initiated actions leading to the modulation of significant cellular processes, important for cancer cell growth and metastasis (including prostate and breast), that involve signaling via specific kinases. Collectively, many nonclassical, cell surface-initiated androgen actions are mediated by novel membrane androgen receptors (mARs), unrelated to nuclear androgen receptors. Recently, our group identified the G protein coupled oxo-eicosanoid receptor 1 (OXER1) (a receptor of the arachidonic acid metabolite, 5-oxoeicosatetraenoic acid, 5-oxoETE) as a novel mAR involved in the rapid effects of androgens. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.01.006DOI Listing
January 2019

Estrogen metabolism pathways in preeclampsia and normal pregnancy.

Steroids 2019 Jan 25;144:8-14. Epub 2019 Jan 25.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, United States.

Background: Experimental studies suggest that shallow uterine cytotrophoblastic invasion in preeclampsia may be associated with alterations in estrogen metabolism. The objective of this study was to examine the association of parent estrogens and their metabolites between preeclamptics and normotensive controls at three time points during pregnancy. Methods Parent estrogens and their metabolites were measured in urine by high-performance liquid chromatography-tandem mass spectrometry in 66 singleton preeclampsia cases and 137 matched controls. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.01.005DOI Listing
January 2019
3 Reads

Alpha lipoic acid protects against dexamethasone-induced metabolic abnormalities via APPL1 and PGC-1 α up regulation.

Steroids 2019 Jan 24;144:1-7. Epub 2019 Jan 24.

Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt.

Background: Glucocorticoids (GCs) have various uses in the medicine in different specialties. However, GCs administration is usually accompanying with multiple side effects such as hyperglycemia and hyperlipidemia. Alpha lipoic acid (ALA) has been documented to posse anti-diabetic properties. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.01.004DOI Listing
January 2019
1 Read

Expression of aromatase and synthesis of sex steroid hormones in skeletal muscle following exercise training in ovariectomized rats.

Steroids 2019 Mar 18;143:91-96. Epub 2019 Jan 18.

Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.

Age-related muscle wasting (sarcopenia) is accompanied by a decrease in estrogen levels which can compromise the health of aging women. Recent studies have shown that the key enzyme of estrogen synthesis (aromatase) is detected in the skeletal muscle. The purpose of this study was to investigate the effects of exercise on the expression of aromatase and the synthesis of sex steroid hormones in skeletal muscle following exercise training. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.01.003DOI Listing
March 2019
3 Reads

Ile351, Leu355 and Ile461 residues are essential for catalytic activity of bovine cytochrome P450scc (CYP11A1).

Steroids 2019 Mar 11;143:80-90. Epub 2019 Jan 11.

Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia. Electronic address:

Cytochrome P450scc (CYP11A1) is a mammalian mitochondrial enzyme which catalyzes cholesterol side chain cleavage to form pregnenolone. Along with cholesterol, some other steroids including sterols with a branched side chain like β-sitosterol are the substrates for the enzyme, but the activity towards β-sitosterol is rather low. Modification of the catalytic site conformation could provide more effective β-sitosterol bioconversion by the enzyme. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.01.002DOI Listing
March 2019
2 Reads

Characterization of a highly specific monoclonal antibody against human aldo-keto reductase AKR1C3.

Steroids 2019 Mar 11;143:73-79. Epub 2019 Jan 11.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address:

Human aldo-keto reductase AKR1C3 (type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase) is involved in testosterone and estrogen metabolism. AKR1C3 expression is relatively low in most tissues and high in prostate and mammary glands in regulating androgen and estrogen levels. However, in many cancers, overexpression of AKR1C3 was observed, thus prompting the development of therapeutics targeting AKR1C3. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.01.001DOI Listing
March 2019
1 Read

Establishment of reference intervals for serum concentrations of androstanediol glucuronide by a newly developed LC-MS/MS method.

Steroids 2019 Mar 6;143:62-66. Epub 2019 Jan 6.

Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, Liège, Belgium.

Background: Androstanediol glucuronide is linked to a range of disorders of peripheral androgen formation and action, such as in hirsutism and acne. Nowadays its accurate quantification is still challenging and there are just a few LC-MS/MS methods available. Besides, their reference intervals for normal European populations by LC-MS/MS, including prepubertal and pubertal children, have not been reported yet. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.008DOI Listing
March 2019
2 Reads

Biotransformation of progestonic hormone dydrogesterone with Macrophomina phaseolina, and study of the effect of biotransformed products on phagocytes oxidative burst.

Steroids 2019 Mar 6;143:67-72. Epub 2019 Jan 6.

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21412, Saudi Arabia. Electronic address:

Biotransformation of a synthetic progestonic hormone dydrogesterone (1), CHO, with a plant pathogenic fungus Macrophomina phaseolina yielded two new 2 and 3, and a known 4 metabolites. These analogues were identified as, 3β,11α-dihydroxy-5β,9β,10α-pregna-7-ene-6,20-dione (2), 15β-hydroxy-9β,10α-pregna-4,6-diene-3,20-dione (3), and 8α-hydroxy-9β,10α-pregna-4,6-diene-3,20-dione (4). Major structural changes were observed in metabolite 2. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.009DOI Listing
March 2019
1 Read

Research on isoprenoids is of great relevance to human life.

Steroids 2019 Jan 4. Epub 2019 Jan 4.

Institute of Chemistry, University of Bialystok, PL 15-245 Białystok, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2018.12.006DOI Listing
January 2019
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Design, synthesis and antitumor activity of steroidal pyridine derivatives based on molecular docking.

Steroids 2019 Mar 25;143:53-61. Epub 2018 Dec 25.

College of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, China; Key Laboratory of Development and Application of Forest Chemicals of Guangxi, Nanning 530006, China. Electronic address:

With steroid as a carrier nucleus and introducing a pyridine heterocycle as a pharmacophore on the D ring, a series of steroidal pyridine derivatives were designed and studied for their antitumor activity by molecular docking software. The compounds were synthesized as small molecule inhibitors and studied as anticancer agents. The synthesis of the analogs was performed in a one-pot multi-component reaction and the corresponding compounds were screened in vitro for their antitumor activity. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.007DOI Listing
March 2019
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Structural analysis of 25-hydroxycholesterol stereoisomers differing in configuration in position 17 and 20, by three-dimensional NMR spectra.

Steroids 2019 Mar 22;143:49-52. Epub 2018 Dec 22.

Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

The application of 3D NMR experiments and DFT calculations enabled the structure investigation of C-17 epimer of 3-(25-hydroxycholest-5-enyl) acetate is presented. The H-17 and H-20 protons features the same values of H chemical shift, what causes that the structure elucidation require additional resolution enabled by 3D NMR experiments. The NMR experiments and theoretical calculations allowed for: the resonance assignment (3D COSY-HMBC and 3D TOCSY-HSQC techniques), the prediction of spatial structure (3D NOESY-HSQC and 3D ROESY-HSQC experiments), and the precise measurement of heteronuclear coupling constants (3D HSQC-TOCSY spectra with E. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.005DOI Listing
March 2019
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First report of a lactonic disecosteroid from the buccinid gastropod Babylonia spirata.

Steroids 2019 Mar 17;143:41-48. Epub 2018 Dec 17.

Marine Biotechnology Division, Central Marine Fisheries Research Institute, Ernakulam North, P.B. No. 1603, Cochin, India.

A lactonic steroid with an unprecedented 1, 10: 8, 9-disecoergostane framework was identified from the ethyl acetate-methanol extract of buccinid gastropod mollusk, Babylonia spirata collected from the southwestern coast of Indian peninsular region. The compound was characterized as 1, 10: 8, 9-disecoergosta-8-en-A-homo-6a-oxa-1-one by exhaustive spectroscopic methods including two-dimensional nuclear magnetic resonance and mass spectroscopic investigations. The disecosteroid displayed moderate carbolytic enzyme inhibition activity as distinguished by its inhibitive effects against α-amylase and α-glucosidase (IC 0. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.004DOI Listing
March 2019
1 Read

Cholesterol biosensors: A review.

Steroids 2019 Mar 10;143:6-17. Epub 2018 Dec 10.

Department of Biotechnology, Deen Bandhu Chhotu Ram University of Science and Technology, Murthal, Sonipat, India.

Cholesterol is the most important sterol synthesized by most of the human cells majorly in the liver. It is a necessary constituent of cell membranes, it acts as a precursor for the synthesis of steroid hormones, vitamin D, and bile acids. Cholesterol is transported in plasma primarily in the form of low-density lipoproteins (LDL), the principal route for its removal from tissues to the liver is in high-density lipoproteins (HDL), followed by excretion in the bile. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.003DOI Listing
March 2019
1 Read

Cytotoxic epimeric ginsenosides from the flower buds of Panax ginseng.

Steroids 2019 Mar 10;143:1-5. Epub 2018 Dec 10.

College of Life Science, Dalian Minzu University, Dalian 116600, People's Republic of China. Electronic address:

Three pairs of ginsenoside epimers, including three new compounds (2, 3 and 5), were isolated from the flower buds of Panax ginseng. The structures of the isolated compounds were elucidated on the basis of considerable spectroscopic analyses and comparison with the reported data. All six compounds were evaluated for their cytotoxicties against three human cancer cell lines, HL-60, MGC80-3 and Hep-G2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183022
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http://dx.doi.org/10.1016/j.steroids.2018.12.002DOI Listing
March 2019
7 Reads
2.639 Impact Factor

Ontogenesis of human fetal testicular steroidogenesis at early gestational age.

Steroids 2019 Jan 4;141:96-103. Epub 2018 Dec 4.

Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Stockholm, Sweden. Electronic address:

The onset of steroidogenesis in human fetal testes (HFT) during the first trimester is poorly investigated. One important unresolved question is the ontogeny of steroidogenic enzymes and formation of steroidogenic pathways in the HFT at early pregnancy. Our aim was to explore steroidogenesis, the expression of steroidogenic enzymes and their maturation in the HFT at gestational weeks (GW) 8-12. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.001DOI Listing
January 2019
2 Reads

Design, synthesis and anti-tumor evaluation of novel steroidal glycoconjugate with furoxan derivatives.

Steroids 2019 Jan 3;141:81-95. Epub 2018 Dec 3.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address:

In this study, eighteen novel steroidal-furoxan derivatives with 3-glycosyl or 3-methoxy moiety (12a-c, 13a-c, 17a-c, 26a-c, 27a-c and 28a-c) were synthesized and their anti-proliferative activity was evaluated against eight drug-sensitive and three drug-resistant cancer cell lines HeLa, A2780, LNCaP, PC-3, MDA-MB-231, MCF-7, SW480, A549, MCF-7/ADR, A2780/CDDP and A2780/T. Most of them displayed significant anti-cancer potency in vitro with IC values at the nanomole level. Among them, 3-methoxy steroidal-furoxan hybrids expressed much better activity than that of 3-glycosyl substitute ones, while estrane and 5α-H-androstane scaffold were slightly more favorable to the improvement of anti-proliferative activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183022
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http://dx.doi.org/10.1016/j.steroids.2018.11.018DOI Listing
January 2019
11 Reads

Impact of the UGT2B17 polymorphism on the steroid profile. Results of a crossover clinical trial in athletes submitted to testosterone administration.

Steroids 2019 Jan 29;141:104-113. Epub 2018 Nov 29.

Preventive Medicine Service, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria IdISSC, Hospital Clínico San Carlos, Madrid, Spain.

This article studies the genetic influence of polymorphism of the UGT2B17 gen on the urinary steroid profile and its implications for the anti-doping field. The study presents the results of a triple-blind randomized placebo-controlled crossover trial with healthy athletes submitted to a single dose of 250 mg of testosterone cypionate. Forty urine samples were collected from each participant. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.009DOI Listing
January 2019
2 Reads

Steroid hormone calcitriol and its analog tacalcitol inhibit miR-125b expression in a human breast cancer MCF-7 cell line.

Steroids 2019 Jan 29;141:70-75. Epub 2018 Nov 29.

Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R. Weigla Street, 53-114 Wroclaw, Poland. Electronic address:

MiR-125b belongs to the class of microRNAs, which are short endogenous non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. Recently, it was reported that miR-125b was found to promote migration and invasion of MCF-7 cells and was involved in chemotherapeutic resistance. Decreasing miR-125b expression would have potential therapeutic significance in preventing dissemination of breast cancer cells. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.014DOI Listing
January 2019
2 Reads

Screening, preparation and characterization of diosgenin versatile solvates.

Steroids 2019 Mar 1;143:18-24. Epub 2018 Dec 1.

Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:

Solvatomorphism occurred in diosgenin solvates. A series of solvates including DMSO, DMF, DMAC, Methanol of diosgenin were obtained and crystallized in order to compare their structures and properties in the solid state. Single-crystal X-ray diffraction was used to analyze the crystal structures and the solvent types and the stoichiometric ratio of the diosgenin solvates. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.016DOI Listing
March 2019
2 Reads

Synthesis of steroid bisglucuronide and sulfate glucuronide reference materials: Unearthing neglected treasures of steroid metabolism.

Steroids 2019 Mar 1;143:25-40. Epub 2018 Dec 1.

Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia. Electronic address:

Doubly or bisconjugated steroid metabolites have long been known as minor components of the steroid profile that have traditionally been studied by laborious and indirect fractionation, hydrolysis and gas chromatography-mass spectrometry (GC-MS) analysis. Recently, the synthesis and characterisation of steroid bis(sulfate) (aka disulfate or bis-sulfate) reference materials enabled the liquid chromatography-tandem mass spectrometry (LC-MS/MS) study of this metabolite class and the development of a constant ion loss (CIL) scan method for the direct and untargeted detection of steroid bis(sulfate) metabolites. Methods for the direct LC-MS/MS detection of other bisconjugated steroids, such as steroid bisglucuronide and mixed steroid sulfate glucuronide metabolites, have great potential to reveal a more complete picture of the steroid profile. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.017DOI Listing
March 2019
2 Reads

Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp.

Steroids 2019 Jan 1;141:76-80. Epub 2018 Dec 1.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address:

Four new polyhydroxylated steroids lobophysterols A-D (1-4), together with two known related compounds sarcophytosterol (5) and klyflaccisteroid B (6), were isolated from the South China Sea soft coral Lobophytum sp. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. In bioassay, compound 4 showed weak cytotoxicities against HT-29, SNU-398, and Capan-1 cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183021
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http://dx.doi.org/10.1016/j.steroids.2018.11.015DOI Listing
January 2019
16 Reads

COUP-TFII revisited: Its role in metabolic gene regulation.

Steroids 2019 Jan 24;141:63-69. Epub 2018 Nov 24.

Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA. Electronic address:

Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) is an orphan member of the nuclear receptor family of transcriptional regulators. Although hormonal activation of COUP-TFII has not yet been identified, rodent genetic models have uncovered vital and diverse roles for COUP-TFII in biological processes. These include control of cardiac function and angiogenesis, reproduction, neuronal development, cell fate and organogenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183021
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http://dx.doi.org/10.1016/j.steroids.2018.11.013DOI Listing
January 2019
13 Reads

Non-holostane aglycones of sea cucumber triterpene glycosides. Structure, biosynthesis, evolution.

Steroids 2018 Nov 22. Epub 2018 Nov 22.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.

Triterpene glycosides are known as characteristic metabolites of sea cucumbers (class Holothuroidea, phylum Echinodermata). The most of them have lanostane aglycones containing 18(20)-lactone, i.e. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.010DOI Listing
November 2018
1 Read

Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study.

Steroids 2019 Jan 22;141:55-62. Epub 2018 Nov 22.

Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.

The ratio of the lengths of the 2nd and 4th digits (2D:4D) is considered an index of prenatal exposure to androgen. Indeed, androgen receptors have been linked to digit length, but estrogen receptors are rarely investigated in this context. Thus, we investigated the association between estrogen receptor 1 (ESR1) genetic polymorphisms and 2D:4D in school-aged children. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.011DOI Listing
January 2019
9 Reads

Convenient synthesis of the immunogenic glycolipid BbGL1.

Steroids 2019 Jan 22;141:41-45. Epub 2018 Nov 22.

Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina. Electronic address:

A simple and efficient method to synthesize the immunogenic glycolipid BbGL1 is introduced. Two simple steps were required to obtain the desired product in good yield. First, a highly efficient glycosylation of cholesterol using galactosyl trichloroacetimidate as a donor was performed to produce cholesteryl-β-d-galactoside. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.012DOI Listing
January 2019
2 Reads

Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins.

Steroids 2018 Nov 17. Epub 2018 Nov 17.

International Research and Production Holding "Phytochemistry", 470000 Karaganda, Kazakhstan. Electronic address:

20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183021
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http://dx.doi.org/10.1016/j.steroids.2018.11.007DOI Listing
November 2018
11 Reads
2.639 Impact Factor

Effect of saponins from quinoa on a skin-mimetic lipid monolayer containing cholesterol.

Steroids 2018 Nov 17. Epub 2018 Nov 17.

Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland; SaponLabs Ltd, Noakowskiego 3, 00-664 Warsaw, Poland. Electronic address:

The study discusses the effect of a quinoa seed coat extract on a cholesterol-based Langmuir monolayer mimicking the intercellular lipid mixture in the skin's outermost layer - stratum corneum. Besides cholesterol (CHOL), the monolayer contains also stearic acid (SA) and ceramide VI (CER), in a molar ratio of 10:14:14. Three quinoa extracts were tested for their surface activity: a) from the whole seed, b) from the dehulled seed, and c) from the seed coat. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.008DOI Listing
November 2018
14 Reads

Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry.

Steroids 2019 Jan 17;141:46-54. Epub 2018 Nov 17.

Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.

Conjugated equine estrogens (CEE) have been widely used by women who seek to relieve symptoms of menopause. Despite evidence describing protective effects against risk factors for cardiovascular diseases by naturally occurring estrogens, little is known about the vascular effects of equilin, one of the main components of CEE and not physiologically present in women. In this regard, the present study aims to compare the vascular effects of equilin in an experimental model of hypertension with those induced by 17β-estradiol. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.006DOI Listing
January 2019
7 Reads

Cytotoxicity and molecular docking studies on phytosterols isolated from Polygonum hydropiper L.

Steroids 2019 Jan 13;141:30-35. Epub 2018 Nov 13.

Department of Biotechnology, University of Malakand, Chakdara 18000, Dir (L), KPK, Pakistan. Electronic address:

Based on our previous studies on cytotoxic potentials of Polygonum hydropiper L, two steroidal compounds beta-sitosterol and stigmasterol were isolated from the most active fraction and were subjected to cell lines cytotoxicity. Isolated compounds were tested against HeLa, MCF-7 and NIH/3T3 cell lines following MTT assay. Furthermore, the compounds were also docked against tyrosine kinase enzyme to predict the binding mode of phytosterols in the active sites of the enzyme. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183020
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http://dx.doi.org/10.1016/j.steroids.2018.11.005DOI Listing
January 2019
8 Reads

Sex-based differences in resting MAPK, androgen, and glucocorticoid receptor phosphorylation in human skeletal muscle.

Steroids 2019 Jan 7;141:23-29. Epub 2018 Nov 7.

Northwest Missouri State University, School of Health Science and Wellness, Maryville 64468, MO, United States. Electronic address:

Purpose: To determine if there is differential expression and phosphorylation of the androgen receptor (AR), glucocorticoid receptor (GR), and mitogen-activated protein kinases (MAPK) in skeletal muscle at rest between males and females.

Methods: Ten college-aged males (mean ± SD; age = 22 ± 2.4 yrs, ht = 175 ± 7 cm, body mass = 84. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.004DOI Listing
January 2019
5 Reads

Two new 4-methylidene containing steroids, craterol A and B, from the New Zealand two sponge association between Stelletta crater and Desmacella dendyi.

Steroids 2019 Jan 7;141:9-13. Epub 2018 Nov 7.

School of Chemical & Physical Sciences, Victoria University of Wellington, Wellington, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, New Zealand. Electronic address:

NMR-directed investigation of the two sponge association between Stelletta crater and Desmacella dendyi has resulted in the isolation of two new members of the rare 4-methylidene class of sterols. Craterol A (1) and B (2) represent the first examples of natural products reported from the species S. crater. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.002DOI Listing
January 2019
5 Reads

Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels.

Steroids 2018 Dec 7;140:179-184. Epub 2018 Nov 7.

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Objective: Elevated midnight cortisol levels induced by non-suppressed ACTH levels may lead to false-positive results for hypercortisolism in patients with adrenal incidentaloma. We investigated whether plasma ACTH-associated high midnight serum cortisol levels are correlated with other endocrinological findings with respect to hypothalamic-pituitaryadrenal function or hypercortisolism status.

Methods: Two-hundred-forty-six patients with adrenocortical adenoma were evaluated via measurements of midnight ACTH and cortisol levels, a 1-mg dexamethasone suppression test (DST), and a cosyntropin-releasing hormone (CRH) stimulation test. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.10.011DOI Listing
December 2018
10 Reads

1,25-Dihydroxyvitamin D induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: A pilot study.

Steroids 2019 Jan 7;141:14-22. Epub 2018 Nov 7.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

Neutrophils are components of the innate immune system that participate in controlling infectious diseases through microbicidal mechanisms such as phagocytosis, degranulation and the release of neutrophil extracellular traps (NETs). NETs are DNA structures that are released through the decondensation and spreading of chromatin and the adherence of various proteins, including neutrophil elastase (NE), myeloperoxidase (MPO) and peptidyl arginine deiminase 4 (PDA4). Since NETs recovered after treatment of activated polymorphonuclear neutrophils can enhance IL-1β and IFN-α production by LPS-activated macrophages, they are thought to be keys to the host's defenses and inflammation. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.11.001DOI Listing
January 2019
10 Reads

Control of β-sitosterol biosynthesis under light and watering in desert plant Calotropis procera.

Steroids 2019 Jan 7;141:1-8. Epub 2018 Nov 7.

Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Genetics, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.

Most scientific studies on Calotropis procera refer to the plant as an important source of pharmaceutical compounds and its valuable benefits in medicine. One of the most important substances in this plant is the potential immunostimulant β-sitosterol (BS) that acts in improving human health. This study focused on the effects of lighting before and after irrigation on the BS accumulation pathway namely steroid biosynthesis. Read More

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https://www.researchgate.net/profile/Ahmed_Bahieldin
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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183020
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http://dx.doi.org/10.1016/j.steroids.2018.11.003DOI Listing
January 2019
7 Reads
2.639 Impact Factor

Chemical synthesis of 7-oxygenated 12α-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12α-hydroxylase enzyme implicated in cardiovascular health and obesity.

Steroids 2018 Dec 3;140:185-195. Epub 2018 Nov 3.

Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249-0698, United States. Electronic address:

Cholic acid is the endogenous 12α-hydroxylated bile acid, which possesses enhanced cholesterol absorption properties compared to its 12-desoxy counterpart, chenodeoxycholic acid. The oxysterol 12α-hydroxylase enzyme is cytochrome P450 8B1 (P450 8B1), which regioselectively and stereoselectively incorporates the 12α-hydroxy group in 7α-hydroxycholest-4-en-3-one, the biosynthetic precursor of cholic acid. Despite the vital role of P450 8B1 activity in cardiovascular health, research studies of other 12α-hydroxy steroid derivatives are rare. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249089PMC
December 2018
2 Reads
2.640 Impact Factor

A facile synthesis of ursodeoxycholic acid and obeticholic acid from cholic acid.

Steroids 2018 Dec 31;140:173-178. Epub 2018 Oct 31.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University, Shanghai 200241, China. Electronic address:

A novel synthetic route of producing ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) was developed through multiple reactions from cheap and readily-available cholic acid. The reaction conditions of the key elimination reaction of mesylate ester group were also investigated and optimized, including solvent, base and reaction temperature. In the straightforward synthetic route for preparation of UDCA and OCA, most of the reaction steps have high conversions with average yields of 94% and 92%, and overall yield up to 65% (7 steps) and 36% (11 steps) from cholic acid, respectively. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.10.009DOI Listing
December 2018
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Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis.

Steroids 2018 Dec 21;140:159-166. Epub 2018 Oct 21.

ReveraGen BioPharma, 155 Gibbs St., Suite 433, Rockville, MD 20850, USA; School of Pharmacy and Pharmaceutical Sciences, Binghamton University - SUNY, 4400 Vestal Pkwy E, Binghamton, NY 13902, USA. Electronic address:

Glucocorticoids are standard of care for many chronic inflammatory conditions, including juvenile dermatomyositis (JDM) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We sought to define pharmacodynamic biomarkers of therapeutic efficacy and safety concerns of glucocorticoid treatment for these two disorders. Previous proteomic profiling of patients with Duchenne muscular dystrophy (DMD) and inflammatory bowel disease (IBD) treated with glucocorticoids identified candidate biomarkers for efficacy and safety concerns of glucocorticoids. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.10.008DOI Listing
December 2018
12 Reads

Study on the reaction of diosgenin acetate with trimethylsilylazide catalyzed by Lewis acids.

Steroids 2018 Oct 14. Epub 2018 Oct 14.

Institute of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland.

The ring opening reaction of diosgenin acetate in presence of Lewis acids and trimethylsilyl azide was explored as a facile approach to the synthesis of an open chain derivative with a nitrogen-containing substituent at C26. The reaction, under optimal conditions (TMSOTf, 1 equiv.; TMSN, 1. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.10.007DOI Listing
October 2018
9 Reads

Highly oxygenated isoprenoid lipids derived from fungi and fungal endophytes: Origin and biological activities.

Steroids 2018 Dec 14;140:114-124. Epub 2018 Oct 14.

Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge AB T1K 1L6, Canada; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation; National Scientific Center of Marine Biology, Vladivostok 690041, Russian Federation. Electronic address:

This mini review is devoted to highly oxygenated isoprenoid lipids (HOIL) that are produced by fungi and fungal endophytes from various ecological niches, both terrestrial and aquatic. Steroids were distributed as from edible cultivated fungi, as well as fungi collected in forests. Fungal endophytes were generally isolated from plants and cultured to obtain sufficient biomass. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.10.006DOI Listing
December 2018
2 Reads

Synthesis, cytotoxic evaluation, and molecular docking studies of the semi-synthetic "triterpenoid-steroid" hybrids.

Steroids 2018 Dec 11;140:131-143. Epub 2018 Oct 11.

Institute of Technical Chemistry, Perm Federal Scientific Centre, Ural Branch, Russian Academy of Sciences, 3 Akad. Korolev str., 614013 Perm, Russia. Electronic address:

Synthetic transformations of steroids for drug discovery and improvement of drug effectiveness have been an important part of modern medicinal chemistry and pharmaceutical sciences. Pentacyclic triterpenoids, being represented in the nature by various structures and biogenetically related to steroids, can largely expand the spectrum of biologically active steroidal agents via synthesis of the so-called "triterpenoid-steroid" hybrids. In the presented work, the nitrile anion cyclizations of 3,4-secolupane and 3,4-seco-oleanane nitriles and follow-up synthetic transformations of the cyclized products with formation of the gemm-dimethyl-free A ring "triterpenoid-steroid" hybrids were studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183019
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http://dx.doi.org/10.1016/j.steroids.2018.10.005DOI Listing
December 2018
5 Reads