6,964 results match your criteria Steroids[Journal]


Cholesterol Biosensors: A review.

Steroids 2018 Dec 10. Epub 2018 Dec 10.

Department of Biotechnology, Deen Bandhu Chhotu Ram University of Science and Technology, Murthal, Sonipat, India.

Cholesterol is the most important sterol synthesized by most of the human cells majorly in the liver. It is a necessary constituent of cell membranes, it acts as a precursor for the synthesis of steroid hormones, vitamin D, and bile acids. Cholesterol is transported in plasma primarily in the form of low-density lipoproteins (LDL), the principal route for its removal from tissues to the liver is in high-density lipoproteins (HDL), followed by excretion in the bile. Read More

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December 2018

Cytotoxic epimeric ginsenosides from the flower buds of Panax ginseng.

Steroids 2018 Dec 10;143:1-5. Epub 2018 Dec 10.

College of Life Science, Dalian Minzu University, Dalian 116600, People's Republic of China. Electronic address:

Three pairs of ginsenoside epimers, including three new compounds (2, 3 and 5), were isolated from the flower buds of Panax ginseng. The structures of the isolated compounds were elucidated on the basis of considerable spectroscopic analyses and comparison with the reported data. All six compounds were evaluated for their cytotoxicties against three human cancer cell lines, HL-60, MGC80-3 and Hep-G2. Read More

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December 2018
1 Read

Ontogenesis of human fetal testicular steroidogenesis at early gestational age.

Steroids 2018 Dec 4;141:96-103. Epub 2018 Dec 4.

Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Stockholm, Sweden. Electronic address:

The onset of steroidogenesis in human fetal testes (HFT) during the first trimester is poorly investigated. One important unresolved question is the ontogeny of steroidogenic enzymes and formation of steroidogenic pathways in the HFT at early pregnancy. Our aim was to explore steroidogenesis, the expression of steroidogenic enzymes and their maturation in the HFT at gestational weeks (GW) 8-12. Read More

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December 2018

Design, synthesis and anti-tumor evaluation of novel steroidal glycoconjugate with furoxan derivatives.

Steroids 2018 Dec 3;141:81-95. Epub 2018 Dec 3.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address:

In this study, eighteen novel steroidal-furoxan derivatives with 3-glycosyl or 3-methoxy moiety (12a-c, 13a-c, 17a-c, 26a-c, 27a-c and 28a-c) were synthesized and their anti-proliferative activity was evaluated against eight drug-sensitive and three drug-resistant cancer cell lines HeLa, A2780, LNCaP, PC-3, MDA-MB-231, MCF-7, SW480, A549, MCF-7/ADR, A2780/CDDP and A2780/T. Most of them displayed significant anti-cancer potency in vitro with IC values at the nanomole level. Among them, 3-methoxy steroidal-furoxan hybrids expressed much better activity than that of 3-glycosyl substitute ones, while estrane and 5α-H-androstane scaffold were slightly more favorable to the improvement of anti-proliferative activity. Read More

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December 2018
4 Reads

Impact of the UGT2B17 polymorphism on the steroid profile. Results of a crossover clinical trial in athletes submitted to testosterone administration.

Steroids 2018 Nov 29;141:104-113. Epub 2018 Nov 29.

Preventive Medicine Service, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria IdISSC, Hospital Clínico San Carlos, Madrid, Spain.

This article studies the genetic influence of polymorphism of the UGT2B17 gen on the urinary steroid profile and its implications for the anti-doping field. The study presents the results of a triple-blind randomized placebo-controlled crossover trial with healthy athletes submitted to a single dose of 250 mg of testosterone cypionate. Forty urine samples were collected from each participant. Read More

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November 2018
1 Read

Steroid hormone calcitriol and its analog tacalcitol inhibit miR-125b expression in a human breast cancer MCF-7 cell line.

Steroids 2018 Nov 29;141:70-75. Epub 2018 Nov 29.

Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R. Weigla Street, 53-114 Wroclaw, Poland. Electronic address:

MiR-125b belongs to the class of microRNAs, which are short endogenous non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. Recently, it was reported that miR-125b was found to promote migration and invasion of MCF-7 cells and was involved in chemotherapeutic resistance. Decreasing miR-125b expression would have potential therapeutic significance in preventing dissemination of breast cancer cells. Read More

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November 2018

Screening, preparation and characterization of diosgenin versatile solvates.

Steroids 2018 Dec 1. Epub 2018 Dec 1.

Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:

Solvatomorphism occurred in diosgenin solvates. A series of solvates including DMSO, DMF, DMAC, Methanol of diosgenin were obtained and crystallized in order to compare their structures and properties in the solid state. Single-crystal X-ray diffraction was used to analyze the crystal structures and the solvent types and the stoichiometric ratio of the diosgenin solvates. Read More

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December 2018

Synthesis of Steroid Bisglucuronide and Sulfate Glucuronide Reference Materials: Unearthing Neglected Treasures of Steroid Metabolism.

Steroids 2018 Dec 1. Epub 2018 Dec 1.

Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia. Electronic address:

Doubly or bisconjugated steroid metabolites have long been known as minor components of the steroid profile that have traditionally been studied by laborious and indirect fractionation, hydrolysis and gas chromatography-mass spectrometry (GC-MS) analysis. Recently, the synthesis and characterisation of steroid bis(sulfate) (aka disulfate or bis-sulfate) reference materials enabled the liquid chromatography-tandem mass spectrometry (LC-MS/MS) study of this metabolite class and the development of a constant ion loss (CIL) scan method for the direct and untargeted detection of steroid bis(sulfate) metabolites. Methods for direct LC-MS/MS detection of other bisconjugated steroids, such as steroid bisglucuronide and mixed steroid sulfate glucuronide metabolites, have great potential to reveal a more complete picture of the steroid profile. Read More

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December 2018

Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp.

Steroids 2018 Dec 1;141:76-80. Epub 2018 Dec 1.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address:

Four new polyhydroxylated steroids lobophysterols A-D (1-4), together with two known related compounds sarcophytosterol (5) and klyflaccisteroid B (6), were isolated from the South China Sea soft coral Lobophytum sp. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. In bioassay, compound 4 showed weak cytotoxicities against HT-29, SNU-398, and Capan-1 cells. Read More

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December 2018
4 Reads

COUP-TFII revisited: Its role in metabolic gene regulation.

Steroids 2018 Nov 24;141:63-69. Epub 2018 Nov 24.

Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA. Electronic address:

Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) is an orphan member of the nuclear receptor family of transcriptional regulators. Although hormonal activation of COUP-TFII has not yet been identified, rodent genetic models have uncovered vital and diverse roles for COUP-TFII in biological processes. These include control of cardiac function and angiogenesis, reproduction, neuronal development, cell fate and organogenesis. Read More

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November 2018
4 Reads

Non-holostane aglycones of sea cucumber triterpene glycosides. Structure, biosynthesis, evolution.

Steroids 2018 Nov 22. Epub 2018 Nov 22.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.

Triterpene glycosides are known as characteristic metabolites of sea cucumbers (class Holothuroidea, phylum Echinodermata). The most of them have lanostane aglycones containing 18(20)-lactone, i.e. Read More

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November 2018

Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study.

Steroids 2018 Nov 22;141:55-62. Epub 2018 Nov 22.

Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.

The ratio of the lengths of the 2nd and 4th digits (2D:4D) is considered an index of prenatal exposure to androgen. Indeed, androgen receptors have been linked to digit length, but estrogen receptors are rarely investigated in this context. Thus, we investigated the association between estrogen receptor 1 (ESR1) genetic polymorphisms and 2D:4D in school-aged children. Read More

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November 2018

Convenient synthesis of the immunogenic glycolipid BbGL1.

Steroids 2018 Nov 22;141:41-45. Epub 2018 Nov 22.

Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina. Electronic address:

A simple and efficient method to synthesize the immunogenic glycolipid BbGL1 is introduced. Two simple steps were required to obtain the desired product in good yield. First, a highly efficient glycosylation of cholesterol using galactosyl trichloroacetimidate as a donor was performed to produce cholesteryl-β-d-galactoside. Read More

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November 2018
1 Read

Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins.

Steroids 2018 Nov 17. Epub 2018 Nov 17.

International Research and Production Holding "Phytochemistry", 470000 Karaganda, Kazakhstan. Electronic address:

20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. Read More

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November 2018
5 Reads

Effect of saponins from quinoa on a skin-mimetic lipid monolayer containing cholesterol.

Steroids 2018 Nov 17. Epub 2018 Nov 17.

Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland; SaponLabs Ltd, Noakowskiego 3, 00-664 Warsaw, Poland. Electronic address:

The study discusses the effect of a quinoa seed coat extract on a cholesterol-based Langmuir monolayer mimicking the intercellular lipid mixture in the skin's outermost layer - stratum corneum. Besides cholesterol (CHOL), the monolayer contains also stearic acid (SA) and ceramide VI (CER), in a molar ratio of 10:14:14. Three quinoa extracts were tested for their surface activity: a) from the whole seed, b) from the dehulled seed, and c) from the seed coat. Read More

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November 2018
8 Reads

Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry.

Steroids 2018 Nov 17;141:46-54. Epub 2018 Nov 17.

Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.

Conjugated equine estrogens (CEE) have been widely used by women who seek to relieve symptoms of menopause. Despite evidence describing protective effects against risk factors for cardiovascular diseases by naturally occurring estrogens, little is known about the vascular effects of equilin, one of the main components of CEE and not physiologically present in women. In this regard, the present study aims to compare the vascular effects of equilin in an experimental model of hypertension with those induced by 17β-estradiol. Read More

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November 2018
2 Reads

Cytotoxicity and molecular docking studies on phytosterols isolated from Polygonum hydropiper L.

Steroids 2018 Nov 13;141:30-35. Epub 2018 Nov 13.

Department of Biotechnology, University of Malakand, Chakdara 18000, Dir (L), KPK, Pakistan. Electronic address:

Based on our previous studies on cytotoxic potentials of Polygonum hydropiper L, two steroidal compounds beta-sitosterol and stigmasterol were isolated from the most active fraction and were subjected to cell lines cytotoxicity. Isolated compounds were tested against HeLa, MCF-7 and NIH/3T3 cell lines following MTT assay. Furthermore, the compounds were also docked against tyrosine kinase enzyme to predict the binding mode of phytosterols in the active sites of the enzyme. Read More

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November 2018
3 Reads

Sex-based differences in resting MAPK, androgen, and glucocorticoid receptor phosphorylation in human skeletal muscle.

Steroids 2018 Nov 7;141:23-29. Epub 2018 Nov 7.

Northwest Missouri State University, School of Health Science and Wellness, Maryville 64468, MO, United States. Electronic address:

Purpose: To determine if there is differential expression and phosphorylation of the androgen receptor (AR), glucocorticoid receptor (GR), and mitogen-activated protein kinases (MAPK) in skeletal muscle at rest between males and females.

Methods: Ten college-aged males (mean ± SD; age = 22 ± 2.4 yrs, ht = 175 ± 7 cm, body mass = 84. Read More

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November 2018
3 Reads

Two new 4-methylidene containing steroids, craterol A and B, from the New Zealand two sponge association between Stelletta crater and Desmacella dendyi.

Steroids 2018 Nov 7;141:9-13. Epub 2018 Nov 7.

School of Chemical & Physical Sciences, Victoria University of Wellington, Wellington, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, New Zealand. Electronic address:

NMR-directed investigation of the two sponge association between Stelletta crater and Desmacella dendyi has resulted in the isolation of two new members of the rare 4-methylidene class of sterols. Craterol A (1) and B (2) represent the first examples of natural products reported from the species S. crater. Read More

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November 2018
4 Reads

Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels.

Steroids 2018 Dec 7;140:179-184. Epub 2018 Nov 7.

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Objective: Elevated midnight cortisol levels induced by non-suppressed ACTH levels may lead to false-positive results for hypercortisolism in patients with adrenal incidentaloma. We investigated whether plasma ACTH-associated high midnight serum cortisol levels are correlated with other endocrinological findings with respect to hypothalamic-pituitaryadrenal function or hypercortisolism status.

Methods: Two-hundred-forty-six patients with adrenocortical adenoma were evaluated via measurements of midnight ACTH and cortisol levels, a 1-mg dexamethasone suppression test (DST), and a cosyntropin-releasing hormone (CRH) stimulation test. Read More

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December 2018
5 Reads

1,25-Dihydroxyvitamin D induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: A pilot study.

Steroids 2018 Nov 7;141:14-22. Epub 2018 Nov 7.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

Neutrophils are components of the innate immune system that participate in controlling infectious diseases through microbicidal mechanisms such as phagocytosis, degranulation and the release of neutrophil extracellular traps (NETs). NETs are DNA structures that are released through the decondensation and spreading of chromatin and the adherence of various proteins, including neutrophil elastase (NE), myeloperoxidase (MPO) and peptidyl arginine deiminase 4 (PDA4). Since NETs recovered after treatment of activated polymorphonuclear neutrophils can enhance IL-1β and IFN-α production by LPS-activated macrophages, they are thought to be keys to the host's defenses and inflammation. Read More

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November 2018
4 Reads

Control of β-sitosterol biosynthesis under light and watering in desert plant Calotropis procera.

Steroids 2018 Nov 7;141:1-8. Epub 2018 Nov 7.

Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Genetics, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.

Most scientific studies on Calotropis procera refer to the plant as an important source of pharmaceutical compounds and its valuable benefits in medicine. One of the most important substances in this plant is the potential immunostimulant β-sitosterol (BS) that acts in improving human health. This study focused on the effects of lighting before and after irrigation on the BS accumulation pathway namely steroid biosynthesis. Read More

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November 2018
3 Reads

Chemical synthesis of 7-oxygenated 12α-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12α-hydroxylase enzyme implicated in cardiovascular health and obesity.

Steroids 2018 Dec 3;140:185-195. Epub 2018 Nov 3.

Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249-0698, United States. Electronic address:

Cholic acid is the endogenous 12α-hydroxylated bile acid, which possesses enhanced cholesterol absorption properties compared to its 12-desoxy counterpart, chenodeoxycholic acid. The oxysterol 12α-hydroxylase enzyme is cytochrome P450 8B1 (P450 8B1), which regioselectively and stereoselectively incorporates the 12α-hydroxy group in 7α-hydroxycholest-4-en-3-one, the biosynthetic precursor of cholic acid. Despite the vital role of P450 8B1 activity in cardiovascular health, research studies of other 12α-hydroxy steroid derivatives are rare. Read More

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December 2018
1 Read
2.640 Impact Factor

A facile synthesis of ursodeoxycholic acid and obeticholic acid from cholic acid.

Steroids 2018 Dec 31;140:173-178. Epub 2018 Oct 31.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University, Shanghai 200241, China. Electronic address:

A novel synthetic route of producing ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) was developed through multiple reactions from cheap and readily-available cholic acid. The reaction conditions of the key elimination reaction of mesylate ester group were also investigated and optimized, including solvent, base and reaction temperature. In the straightforward synthetic route for preparation of UDCA and OCA, most of the reaction steps have high conversions with average yields of 94% and 92%, and overall yield up to 65% (7 steps) and 36% (11 steps) from cholic acid, respectively. Read More

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December 2018

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis.

Steroids 2018 Dec 21;140:159-166. Epub 2018 Oct 21.

ReveraGen BioPharma, 155 Gibbs St., Suite 433, Rockville, MD 20850, USA; School of Pharmacy and Pharmaceutical Sciences, Binghamton University - SUNY, 4400 Vestal Pkwy E, Binghamton, NY 13902, USA. Electronic address:

Glucocorticoids are standard of care for many chronic inflammatory conditions, including juvenile dermatomyositis (JDM) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We sought to define pharmacodynamic biomarkers of therapeutic efficacy and safety concerns of glucocorticoid treatment for these two disorders. Previous proteomic profiling of patients with Duchenne muscular dystrophy (DMD) and inflammatory bowel disease (IBD) treated with glucocorticoids identified candidate biomarkers for efficacy and safety concerns of glucocorticoids. Read More

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December 2018
6 Reads

Study on the reaction of diosgenin acetate with trimethylsilylazide catalyzed by Lewis acids.

Steroids 2018 Oct 14. Epub 2018 Oct 14.

Institute of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland.

The ring opening reaction of diosgenin acetate in presence of Lewis acids and trimethylsilyl azide was explored as a facile approach to the synthesis of an open chain derivative with a nitrogen-containing substituent at C26. The reaction, under optimal conditions (TMSOTf, 1 equiv.; TMSN, 1. Read More

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October 2018
4 Reads

Highly oxygenated isoprenoid lipids derived from fungi and fungal endophytes: Origin and biological activities.

Steroids 2018 Dec 14;140:114-124. Epub 2018 Oct 14.

Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge AB T1K 1L6, Canada; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation; National Scientific Center of Marine Biology, Vladivostok 690041, Russian Federation. Electronic address:

This mini review is devoted to highly oxygenated isoprenoid lipids (HOIL) that are produced by fungi and fungal endophytes from various ecological niches, both terrestrial and aquatic. Steroids were distributed as from edible cultivated fungi, as well as fungi collected in forests. Fungal endophytes were generally isolated from plants and cultured to obtain sufficient biomass. Read More

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December 2018

Synthesis, cytotoxic evaluation, and molecular docking studies of the semi-synthetic "triterpenoid-steroid" hybrids.

Steroids 2018 Dec 11;140:131-143. Epub 2018 Oct 11.

Institute of Technical Chemistry, Perm Federal Scientific Centre, Ural Branch, Russian Academy of Sciences, 3 Akad. Korolev str., 614013 Perm, Russia. Electronic address:

Synthetic transformations of steroids for drug discovery and improvement of drug effectiveness have been an important part of modern medicinal chemistry and pharmaceutical sciences. Pentacyclic triterpenoids, being represented in the nature by various structures and biogenetically related to steroids, can largely expand the spectrum of biologically active steroidal agents via synthesis of the so-called "triterpenoid-steroid" hybrids. In the presented work, the nitrile anion cyclizations of 3,4-secolupane and 3,4-seco-oleanane nitriles and follow-up synthetic transformations of the cyclized products with formation of the gemm-dimethyl-free A ring "triterpenoid-steroid" hybrids were studied. Read More

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December 2018
4 Reads

Synthesis and antiproliferative activity of 17-[1',2',3']-selenadiazolylpregnenolone compounds.

Steroids 2018 Dec 6;140:151-158. Epub 2018 Oct 6.

College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, PR China. Electronic address:

Using pregnenolone as a starting material, some 3-substituted 17-[1',2',3']-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The results show that some compounds display selective antiproliferative activity against PC-3 and SKOV3 cells lines and are almost inactive to normal kidney epithelial cells (HEK293T). Read More

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December 2018
5 Reads

Fluorine-containing lupane triterpenoid acid derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory agents.

Steroids 2018 Oct 5. Epub 2018 Oct 5.

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrent'ev Ave. 9, 630090 Novosibirsk, Russian Federation.

A series of novel fluorine-containing lupane triterpenoid acid derivatives with fluoroaromatic amide moieties at the C-28 position (1-8) or with 2-(fluoroacyl)cyclopentane-1,3-dione fragments at the C-3 position (9-18) of lupane skeleton was synthesized. A simple synthesis of novel lupane triterpenoid hybrids with 2-(fluoroacyl)-2-cyclopenten-1-one moieties was developed. An interaction of 2-acyl-3-chlorocyclopent-2-en-1-ones, obtained from corresponding cyclic β-triketones, with methyl 3-amino-3-deoxybetulinate gave 3β-isomers (9-13) and 3α-isomers (14-18) of target hybrids, which were isolated as individual compounds. Read More

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October 2018
6 Reads

Separation and identification of the epimeric doping agents - Dexamethasone and betamethasone in equine urine and plasma: A reversed phase chiral chromatographic approach.

Steroids 2018 Dec 5;140:77-82. Epub 2018 Oct 5.

Equine Forensic Unit, Central Veterinary Research Laboratory, PO Box 597, Dubai, United Arab Emirates. Electronic address:

Chirality is one of the most important considerations when controlling doping. The epimeric corticosteroids dexamethasone and betamethasone are significantly potent and long-acting, and they are highly abused in equestrian sports. The scope of this study was to develop a simple and reliable analytical method for simultaneously identifying and separating regularly abused co-eluting corticosteroids in equine urine and plasma. Read More

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December 2018
8 Reads

Steroid profiling in nails using liquid chromatography-tandem mass spectrometry.

Steroids 2018 Dec 5;140:144-150. Epub 2018 Oct 5.

Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. Electronic address:

The retrospective analysis of endogenous steroid hormones in nails can be used to elucidate endocrine diseases and thus help with their diagnosis and treatment. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) based method was developed for the simultaneous identification and quantification of 12 steroid hormones (aldosterone, cortisone, cortisol, corticosterone, 11-deoxycortisol, androstenedione, 11-deoxycorticosterone, testosterone, dehydroepiandrosterone (DHEA), 17α-hydroxyprogesterone (17-OHP), dihydrotestosterone (DHT) and progesterone) in human fingernails. Steroid hormones were extracted from 0. Read More

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December 2018
9 Reads

Pregn-5-en-3β-ol and androst-5-en-3β-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability.

Steroids 2018 Oct 5. Epub 2018 Oct 5.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nam. 2, Prague 6, Dejvice 16610, Czech Republic. Electronic address:

Neurosteroids are endogenous steroidal compounds that can modulate neuronal receptors. N-Methyl-D-aspartate receptors (NMDARs) are glutamate-gated, calcium-permeable ion channels that are of particular interest, as they participate in synaptic transmission and are implicated in various processes, such as learning, memory, or long-term neuronal potentiation. Positive allosteric modulators that increase the activity of NMDARs may provide a therapeutic aid for patients suffering from neuropsychiatric disorders where NMDAR hypofunction is thought to be involved, such as intellectual disability, autism spectrum disorder, or schizophrenia. Read More

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October 2018
3 Reads

Timosaponin AIII: A novel potential anti-tumor compound from Anemarrhena asphodeloides.

Steroids 2018 Dec 5;140:125-130. Epub 2018 Oct 5.

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Timosaponin AIII, a major steroidal saponin found in Anemarrhena asphodeloides Bge., which has been widely used as anti-pyretic, anti-diabetic, anti-inflammatory, anti-platelet aggregator and anti-depressant agents in traditional Chinese medicine. Recent pharmacological study showed that timosaponin AIII had potent cytotoxicity, which was potential to be developed as an anticancer agent, however the molecular mechanism underlying the anticancer activity has not been fully elucidated. Read More

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December 2018
6 Reads

Steroids-specific target library for steroids target prediction.

Steroids 2018 Dec 6;140:83-91. Epub 2018 Oct 6.

Center of Bioinformatics, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China. Electronic address:

Steroids exist universally and play critical roles in various biological processes. Identifying potential targets of steroids is of great significance in studying their physiological and biochemical activities, the side effects and for drug repurposing. Herein, aiming at more precise steroids targets prediction, a steroids-specific target library integrating 3325 PDB or homology modeling structures categorized into 196 proteins was built by considering chemical similarity from DrugBank and biological processes from KEGG. Read More

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December 2018
2 Reads

C steroids from Streptocaulon juventas (Lour) Merr. induce apoptosis in HepG2.

Steroids 2018 Dec 6;140:167-172. Epub 2018 Oct 6.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:

Three new C steroids, i.e., (3β,17α,20S)-pregn-5(6)-ene-3, 17, 20-triol-3-O-β-d-digitalopyranosyl-(1 → 4)-β-d-digitalopyranoside (4), (3β,17α,20S)-pregn-5(6)-ene-3, 17, 20-triol-20-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl-(1 → 2)-β-d-digital-opyranoside (8), (3β, 20R)-pregn-14(15)-ene-3, 20, 21-triol-3-O-β-d-glucopy-ranoside (10), along with ten known C steroids were isolated from Streptocaulon juventas. Read More

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December 2018
5 Reads

Expression of oestrogen receptor beta was negatively correlated with disease activity in patients with Crohn's disease involving the terminal ileum.

Steroids 2018 Sep 29;141:36-40. Epub 2018 Sep 29.

Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Crohn's disease (CD) is a chronic inflammatory disease. The recurrence and remission of symptoms in CD patients are associated with changes in hormones, such as in puberty, pregnancy, postpartum and menopause, reflecting that oestrogen and its receptor might play an important role in CD. The study aimed to investigate the expression and clinical significance of oestrogen receptor in patients with CD involving the terminal ileum. Read More

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September 2018
1 Read

Anti-inflammatory furostanol saponins from the rhizomes of Smilax china L.

Steroids 2018 Dec 29;140:70-76. Epub 2018 Sep 29.

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

Seven new furostanol saponins (1-7), chongrenosides A-G, were isolated from the rhizomes of Smilax china L., together with nine known furostanol saponins (8-16). The structures of the new furostanol saponins (1-7) were elucidated by extensive spectroscopic data analyses (1D and 2D NMR, HRESIMS) and chemical evidence. Read More

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December 2018
3 Reads

Chemical synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1.

Steroids 2018 Dec 28;140:104-113. Epub 2018 Sep 28.

Laboratory of Medicinal Chemistry, Oncology and Nephrology Unit, CHU de Québec - Research Center (CHUL T4), Québec, QC, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada. Electronic address:

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a promising therapeutic target known to play a pivotal role in the progression of estrogen-dependent diseases such as breast cancer, and endometriosis. This enzyme is responsible for the last step in the biosynthesis of the most potent estrogen, estradiol (E2) and its inhibition would prevent the growth of estrogen-sensitive tumors. Based on molecular modeling with docking experiments, we identified two promising C3-oxiranyl/oxiranylmethyl-estrane derivatives that would bind competitively and irreversibly in the catalytic site of 17β-HSD1. Read More

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December 2018
2.640 Impact Factor

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements.

Steroids 2018 Dec 29;140:92-103. Epub 2018 Sep 29.

Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen AB24 3UE, Scotland; Instituto de Tecnologia em Fármacos e Farmanguinhos, Fundação Oswaldo Cruz, 21041-250 Rio de Janeiro, RJ, Brazil. Electronic address:

The crystal structures, Hirshfeld surface analyses and electrostatic potential surfaces of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol, 3, namely [3·(HO)] and [3·(HO)], are reported. The trihydrate, isolated from a solution of 3 in moist methanol, recrystallizes in the orthorhombic space group, P222, while that of the dihydrate, isolated from a 1:1 aqueous methanol solution, recrystallizes in the monoclinic space group, P2. The asymmetric unit of the trihydrate involves one steroid and three water molecules, while that of the dihydrate has two similar but independent steroid molecules and four hydrate molecules. Read More

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December 2018
1 Read

Effects of glucocorticoid on the eye development in guinea pigs.

Steroids 2018 Nov 20;139:1-9. Epub 2018 Sep 20.

Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan 250002, China; Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan 250002, China. Electronic address:

Glucocorticoid (GC) has been widely used in clinic. However, the effect of GC on normal and myopic development of eyes is still unknown. In this study, 3-week-old guinea pigs were randomly divided into four groups: No-Lens (control), GC+No-Lens, negative lens-induced myopia (LIM), and GC+LIM. Read More

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November 2018
1 Read

Clickable conjugates of bile acids and nucleosides: Synthesis, characterization, in vitro anticancer and antituberculosis studies.

Steroids 2018 Nov 17;139:35-44. Epub 2018 Sep 17.

Department of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India. Electronic address:

A series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker were synthesized, and characterized by spectroscopic techniques such as H NMR, C NMR, FT-IR, HRMS and HPLC. The synthesized compounds 6a-p were screened for their in vitro anticancer property against a panel of three cancer cell lines (PC-3, MCF-7, IMR-32). In addition, the synthesized derivatives were also tested for their antimycobacterial activity against Mycobacterium tuberculosis HRv (ATCC 27294 strain). Read More

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November 2018
4 Reads
2.640 Impact Factor

Correlation between chronological and physiological age of males from their multivariate urinary endogenous steroid profile and prostatic carcinoma-induced deviation.

Steroids 2018 Nov 16;139:10-17. Epub 2018 Sep 16.

Divisione di Urologia, Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Ospedale San Luigi, Regione Gonzole 10, 10043 Orbassano, Turin, Italy.

The biosynthesis of endogenous androgenic anabolic steroids (EAAS) in males varies with age. Knowledge of the general urinary EAAS profile's dependence from aging - not reported up to now - may represents a prerequisite for its exploitation in the screening and diagnostic support for several pathologies. Extended urinary EAAS profiles were obtained from healthy and pathological individuals, using a GC-MS method which was fully validated by a stepwise, analyst-independent scheme. Read More

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November 2018
7 Reads

Ichnocarpus frutescens (L.) R. Br. root derived phyto-steroids defends inflammation and algesia by pulling down the pro-inflammatory and nociceptive pain mediators: An in-vitro and in-vivo appraisal.

Steroids 2018 Nov 12;139:18-27. Epub 2018 Sep 12.

Dept. of Pharmaceutical Science, Drug Discovery Research Laboratory, Division of Pharmacognosy, Assam University (A Central University), Silchar-788011, Assam, India. Electronic address:

Ichnocarpus frutescens, a climber plant, is distributed all over India. As its different parts are used as anti-inflammatory agent, so we re-investigated the roots to isolate compounds and evaluate its biological efficacy. Also, in-silico molecular docking was carried out to elucidate the structure activity relationship (SAR) of isolated compounds toward identifies the drug target enzyme with validation, which was further supported by anti-inflammatory in-vitro and in-vivo experimental models. Read More

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November 2018
1 Read
2.640 Impact Factor

Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives.

Steroids 2018 Dec 12;140:45-51. Epub 2018 Sep 12.

Laboratorio de Biocatálisis, Departamento de Química Orgánica y UMYMFOR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, piso 3, C1428EGA Buenos Aires, Argentina. Electronic address:

In this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis. Fifteen acetyl and ester derivatives, twelve of them new, were obtained through an enzymatic strategy in a fully regioselective way and in very good to excellent yield. In order to find the optimal reaction conditions, the influence of several parameters such as enzyme source, alcohol or acylating agent:substrate ratio, enzyme:substrate ratio, temperature and reaction solvent was considered. Read More

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December 2018

Lysophosphatidylcholine induces expression of genes involved in cholesterol biosynthesis in THP-1 derived macrophages.

Steroids 2018 Nov 12;139:28-34. Epub 2018 Sep 12.

Clinical Medicine Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea.

Lysophosphatidylcholine (LPC), a major component of oxidized low-density lipoprotein, is associated with atherosclerosis, obesity, stroke, and cancer. However, the direction and mechanism of this relationship remains unclear. In this study, we conducted RNA profiling in THP-1 derived macrophages treated with LPC and uncovered a relationship between LPC and the cholesterol biosynthesis pathway. Read More

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November 2018
1 Read

The sulfatase pathway as estrogen supply in endometrial cancer.

Steroids 2018 Nov 12;139:45-52. Epub 2018 Sep 12.

GROW-School for Oncology & Developmental Biology, Maastricht University, the Netherlands; Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, the Netherlands. Electronic address:

Objective: Contradictory results are reported about the level of steroid sulfatase (STS), estrogen sulfotransferase (SULT1E1; together, the sulfatase pathway) and aromatase (CYP19A1) in endometrial cancer (EC). The aim of this study was to explore the levels of these enzymes in a well-characterized cohort of EC patients and postmenopausal controls.

Materials And Methods: Endometrial tissues from 31 EC patients (21 grade 1 and 10 grade 2-3) and 19 postmenopausal controls were collected. Read More

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November 2018

Estimating testosterone concentrations in adolescent girls: Comparison of two direct immunoassays to liquid chromatography-tandem mass spectrometry.

Steroids 2018 Dec 12;140:62-69. Epub 2018 Sep 12.

Center for Research in Reproduction, University of Virginia School of Medicine, Charlottesville, VA, USA; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.

Context: The appropriate role of direct total testosterone (T) immunoassays in reproductive research is controversial.

Objective: To assess the concordance between two direct immunoassays and a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for total T in adolescent girls with measured concentrations < 50 ng/dl.

Design: Cross-sectional analysis. Read More

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December 2018
5 Reads

Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing's syndrome and healthy controls.

Steroids 2018 Dec 6;140:39-44. Epub 2018 Sep 6.

Department of Endocrinology and Internal Medicine, Medical University of Gdansk, ul. Dębinki 7, 80-288 Gdansk, Poland. Electronic address:

Introduction: In recent years researchers have focused at hormonal activity in Cushing's syndrome (CS) in connection with metabolic disorders and the role of adipokines and cytokines secreted by the adipose tissue. The aim of the study was to investigate levels of adipokines and cytokines in patients with: subclinical CS (SCS) - in relation to hormonal parameters of hypercortisolemia, and, adrenocortical cancer (ACC).

Materials And Methods: The study included 20 SCS as well as 7 ACC patients, and 18 healthy participants. Read More

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December 2018
11 Reads

Two new bioactive steroids from a mangrove-derived fungus Aspergillus sp.

Steroids 2018 Dec 31;140:32-38. Epub 2018 Aug 31.

School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address:

Two unusual naturally Diels-Alder additive steroids, ergosterdiacids A and B (1 and 2), constructing a 6/6/6/6/5 pentacyclic steroidal system, together with three known compounds (3-5) were obtained from the mangrove-derived fungus Aspergillus sp. Their structures were elucidated based on the comprehensive spectroscopic analysis, including 1D, 2D NMR and HRESIMS, as well as the quantum chemical ECD calculations. The plausible biosynthetic pathways of 1 and 2 were discussed. Read More

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December 2018
9 Reads