23,031 results match your criteria Stereotactic and Functional Neurosurgery[Journal]


Radiation recall myelitis following paclitaxel chemotherapy: The first reported case.

J Radiosurg SBRT 2018 ;5(4):331-334

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Introduction: Stereotactic body radiotherapy (SBRT) of the spine has become an increasingly utilized modality in the United States, most commonly for metastatic disease (McClelland et al., 2017). Spinal SBRT in patients with spinal instrumentation has been sparsely examined. Read More

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January 2018

An evaluation of the consistency of shifts reported by three different systems for non-coplanar treatments.

J Radiosurg SBRT 2018 ;5(4):323-330

Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84112, USA.

Treatment of intra-cranial lesions sometimes requires a non-coplanar beam configuration. One of the most commonly used IGRT modalities, kV conebeam CT, cannot typically be used when large couch rotations are introduced. However, multiple other systems allow for imaging/tracking the patient for such situations. Read More

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January 2018

Spatial shifts in frame-based Gamma Knife radiosurgery: A case for cone beam CT imaging as quality assurance using the Gamma Knife® Icon™.

J Radiosurg SBRT 2018 ;5(4):315-322

Department of Neurological Surgery, University of Virginia Medical Center, PO Box 800212, Charlottesville, VA 22908-0212, USA.

Background: Cone beam CT (CBCT) imaging has been integrated into the most recent version of the Leksell Gamma Knife for the primary purpose to facilitate fractionated therapy.

Case Description: This case study presents three patients where the CBCT system of the Gamma Knife Icon discovered potentially clinically significant frame shifts. In each case, patients were imaged with volumetric MR prior to stereotactic frame placement. Read More

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January 2018

Volumetric trends of progressive in-field recurrences after stereotactic radiosurgery of metastatic intracranial tumors.

J Radiosurg SBRT 2018 ;5(4):293-304

Department of Neurological Surgery, Rutgers University, Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.

Objective: Local recurrence after stereotactic radiosurgery for brain metastasis is a well-known problem. We analyzed volumetric trends from the time of radiosurgery to time of treatment to understand progression behavior.

Methods: A retrospective review of patients who underwent treatment for post-radiation progressive lesions was performed. Read More

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January 2018

Impact of diabetes mellitus on outcomes in patients with brain metastasis treated with stereotactic radiosurgery.

J Radiosurg SBRT 2018 ;5(4):285-291

Department of Radiation Oncology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.

Purpose: To determine the influence of diabetes mellitus (DM) on outcomes in patients with brain metastasis treated with stereotactic radiosurgery (SRS).

Methods: We retrospectively reviewed 498 patients with brain metastasis treated at our institution with SRS between January 2012 and March 2017.

Results: Eight-four patients (16. Read More

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January 2018

Potential prognostic markers for survival and neurologic death in patients with breast cancer brain metastases who receive upfront SRS alone.

J Radiosurg SBRT 2018 ;5(4):277-283

Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

Purpose/objectives: Stereotactic radiosurgery (SRS) is used as a treatment option for breast cancer brain metastases. It is unclear what factors predict neurologic death for these patients.

Materials/methods: A total of 128 patients with breast cancer brain metastases were treated with upfront SRS alone in this study. Read More

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January 2018

Linac-based fractionated stereotactic radiosurgery for high-risk meningioma.

J Radiosurg SBRT 2018 ;5(4):269-276

Department of Radiation Oncology at the University of Cincinnati Barrett Cancer Center, 234 Goodman Street, Cincinnati, OH 45219, USA.

Purpose: Single-fraction stereotactic radiosurgery(SRS) for meningioma has high rates of symptomatic perilesional edema in some settings. Fractionated stereotactic radiosurgery(fSRS) could decrease edema rates while maintaining tumor control.

Methods And Materials: Patients at an institution were retrospectively reviewed(2013-2017). Read More

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January 2018

Stereotactic body radiotherapy used as a bridge to liver transplant in patients with hepatocellular carcinoma and Child-Pugh score ≥8 cirrhosis.

J Radiosurg SBRT 2018 ;5(4):261-267

Division of Radiation Oncology, Allegheny Health Network, 320 East North Ave, Pittsburgh, PA 15212, USA.

Introduction: To report on SBRT as a bridge to OLT for patients with HCC and Child-Pugh ≥8 cirrhosis.

Methods: Retrospective review of 15 patients, treated from 2010-2017. Three patients excluded secondary to delisting from prohibitive substance. Read More

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January 2018

Understanding the Effects and Adverse Reactions of Deep Brain Stimulation: Is It Time for a Paradigm Shift Toward a Focus on Heterogenous Biophysical Tissue Properties Instead of Electrode Design Only?

Front Hum Neurosci 2018 27;12:468. Epub 2018 Nov 27.

Center for Psychiatry Emmendingen, Emmendingen, Germany.

Deep brain stimulation (DBS) has been proven to be an effective treatment modality for various late-stage neurological and psychiatric disorders. However, knowledge on the electrical field distribution in the brain tissue is still scarce. Most recent attempts to understand electric field spread were primarily focused on the effect of different electrodes on rather simple tissue models. Read More

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November 2018

Improved Survival Outcomes for Kidney Cancer Patients With Brain Metastases.

Clin Genitourin Cancer 2018 Dec 5. Epub 2018 Dec 5.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX; Division of Hematology and Oncology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX. Electronic address:

Background: Brain metastases (BM) occur frequently in patients with metastatic kidney cancer and are a significant source of morbidity and mortality. Although historically associated with a poor prognosis, survival outcomes for patients in the modern era are incompletely characterized. In particular, outcomes after adjusting for systemic therapy administration and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk factors are not well-known. Read More

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December 2018

Simultaneous optimization of isocenter locations and sector duration in radiosurgery.

Phys Med Biol 2018 Dec 11. Epub 2018 Dec 11.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, CANADA.

Stereotactic radiosurgery is an effective technique to treat brain tumors for which several inverse planning methods may be appropriate. We propose an integer programming model to simultaneous sector duration and isocenter optimization (SDIO) problem for Leksell Gamma Knife{\textregistered} Icon{\texttrademark} (Elekta, Stockholm, Sweden) to tractably incorporate treatment time. We devise a Benders decomposition scheme to solve the SDIO problem to optimality. Read More

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December 2018
1 Read

A chemogenetic approach for treating experimental Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: PD is a common neurodegenerative disease primarily affecting the cortico-basal ganglia loop.

Objective: To investigate whether chemogenetic-mediated neuromodulation of various nuclei and pathways can counterbalance basal ganglia network abnormalities and improve motor disability in experimental PD.

Methods: Experimental PD was induced by stereotactic injection of 6-OHDA to the medial forebrain bundle. Read More

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December 2018
1 Read

Radiation Therapy in HCC: What Data Exist and What Data Do We Need to Incorporate into Guidelines?

Semin Liver Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, University of California San Francisco, San Francisco, California.

Hepatocellular carcinoma (HCC) is a complex and diverse disease, with choice of treatment dependent on a patient's disease burden, location of disease, underlying liver function, and performance status. While radiation therapy (RT) was historically omitted from treatment algorithms, immense technological advances over the past several decades have enabled introduction of RT as an effective and safe treatment option for patients with HCC. Growing prospective and retrospective evidence supports the use of RT, particularly stereotactic body radiotherapy (SBRT), for a wide range of indications in HCC from locally advanced unresectable disease to bridge therapy for liver transplant candidates. Read More

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December 2018

Unconventional Facial Entry Points Confirmed Using a 3D CT Reconstruction-Guided Stereotactic Approach to Radiofrequency Thermocoagulation for the Treatment of Trigeminal Neuralgia: A Series of Case Reports.

Pain Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurosurgery.

Objectives: Patients with trigeminal neuralgia who are refractory to medical therapy may choose to undergo Gasserian ganglion percutaneous radiofrequency thermocoagulation. However, in cases where the foramen ovale is difficult to access due to various anatomical anomalies, the typical estimation of the facial entry point is suboptimal.

Methods: Three-dimensional computed tomography reconstruction imaging performed before surgery revealed anatomical variations in each of the four adult patient cases that made it more difficult to successfully access the foramen ovale (FO) for percutaneous radiofrequency thermocoagulation. Read More

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December 2018

The Role of Standard and Advanced Imaging for the Management of Brain Malignancies From a Radiation Oncology Standpoint.

Neurosurgery 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

Radiation therapy (RT) plays a critical role in the overall management of many central nervous system (CNS) tumors. Advances in RT treatment planning, with techniques such as intensity modulated radiation therapy, volumetric modulated arc therapy, and stereotactic radiosurgery, now allow the delivery of highly conformal dose with great precision. These techniques rely on high-resolution 3-dimensional anatomical imaging modalities such as computed tomography or magnetic resonance imaging (MRI) scans to accurately and reliably define CNS targets and normal tissue avoidance structures. Read More

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December 2018

Chemo-Radiotherapy of Oligometastases of Colorectal Cancer With Pegylated Liposomal Mitomycin-C Prodrug (Promitil): Mechanistic Basis and Preliminary Clinical Experience.

Front Oncol 2018 26;8:544. Epub 2018 Nov 26.

Shaare Zedek Medical Center, Jerusalem, Israel.

Hypo-fractionated radiotherapy and stereotactic body radiotherapy are viable options for treatment of oligometastases. A prodrug of mitomycin-C is under clinical testing as a pegylated liposomal formulation (Promitil) with an improved safety profile over mitomycin-C. Promitil was offered to two patients with oligometastases from colorectal cancer as radiosensitizer. Read More

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November 2018

Stereotactic Lesioning of the Thalamic Vo Nucleus for the Treatment of Writer's Cramp (Focal Hand Dystonia).

Front Neurol 2018 26;9:1008. Epub 2018 Nov 26.

Department of Neurodegenerative Disorders Research, Graduate School of Medical Sciences, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Writer's cramp (focal hand dystonia) is a sporadic focal dystonia that affects a specific part of the upper limb causing excessive co-contraction of antagonistic muscles. It usually presents as a task-specific dystonia, including, among others, writing of a character or playing a musical instrument. Although treatments for writer's cramp exist, medical therapy often results in unsatisfactory outcomes in patients with this type of dystonia. Read More

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November 2018

Surgical Intervention vs. Radiation Therapy: The Shifting Paradigm in Treating Metastatic Spinal Disease.

Cureus 2018 Oct 3;10(10):e3406. Epub 2018 Oct 3.

Radiology, Yale School of Medicine/Yale New Haven Health, New Haven, USA.

The spine is one of the most common sites to which metastatic cancer is likely to spread and is one of the leading causes of morbidity and mortality in cancer patients. While no medical treatments have been definitively shown to extend the life expectancy of patients with spinal metastasis, interventional options may be the only viable option in improving outcomes. Currently, two main options exist: surgical resection and radiotherapy, with radiotherapy being the primary treatment modality. Read More

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October 2018

Deep Brain Stimulation Surgery for Parkinson Disease Coexisting With Communicating Hydrocephalus: A Case Report.

Front Neurol 2018 23;9:1011. Epub 2018 Nov 23.

Hospital Clínico, Universidad de Chile, Santiago, Chile.

We report a successful bilateral globus pallidus internus-deep brain stimulation (GPi-DBS) for a Parkinson disease (PD) patient with idiopathic normal pressure hydrocephalus (INPH) and an unusually long anterior commissure-posterior commissure (AC-PC) line. A 54-year-old man presented with a history of 3 months of severe shuffling gait, rigidity, slow movements of the left side limbs, and difficulty managing finances. A brain MRI revealed marked ventriculomegaly (Evans index = 0. Read More

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November 2018

Tracking, gating, free-breathing, which technique to use for lung stereotactic treatments? A dosimetric comparison.

Rep Pract Oncol Radiother 2019 Jan-Feb;24(1):97-104. Epub 2018 Nov 24.

Institut du Cancer de Montpellier (ICM), Montpellier, France.

Background: The management of breath-induced tumor motion is a major challenge for lung stereotactic body radiation therapy (SBRT). Three techniques are currently available for these treatments: tracking (T), gating (G) and free-breathing (FB).

Aim: To evaluate the dosimetric differences between these three treatment techniques for lung SBRT. Read More

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November 2018
1 Read

Gamma knife radiosurgery for local recurrence of glioblastoma.

Neuro Endocrinol Lett 2018 Oct 12;39(4):281-287. Epub 2018 Oct 12.

Department of Medical Physics, Na Homolce Hospital, Prague, Czech Republic.

Objective: Local recurrence of glioblastoma is observed in most patients after standard oncologic treatment (surgery, chemotherapy and radiotherapy). Stereotactic radiosurgery with the Leksell Gamma Knife (SRS with LGK) was used to treat recurrent tumors in selected cases, and retrospective analysis of treatment outcome was performed.

Methods: Altogether 126 patients were treated for glioblastoma at our center from 1992-2014. Read More

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October 2018

Recent advances in gynecologic radiation oncology.

Curr Opin Obstet Gynecol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiation Oncology, University of California, Los Angeles, USA.

Purpose Of Review: Radiation has long been a primary treatment modality in locally advanced gynecologic carcinomas and a tool for palliation of metastatic disease. Here we review advances in imaging and radiation technologies and the corresponding clinical evolution of the role for radiation oncology in the treatment of gynecologic malignancies.

Recent Findings: Advances in MRI are impacting diagnosis, radiation target delineation, planning, treatment delivery, and response assessment. Read More

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December 2018

Stereotactic Pelvic Navigation With Augmented Reality for Transanal Total Mesorectal Excision.

Dis Colon Rectum 2019 Jan;62(1):123-129

IHU-Strasbourg, Institute for Image-Guided Surgery, Strasbourg, France.

Introduction: Technical difficulty and unfamiliar surgical anatomy are the main challenges in transanal total mesorectal excision. Precise 3-dimensional real-time image guidance may facilitate the safety, accuracy, and efficiency of transanal total mesorectal excision.

Technique: A preoperative CT was obtained with 10 skin fiducials and further processed to emphasize the border of the anatomical structure by 3-dimensional modeling and pelvic organ segmentation. Read More

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January 2019
2 Reads

Effect of Tumor Location and Dosimetric Predictors for Chest Wall Toxicity in Single Fraction SBRT for Stage I Non-Small Cell Lung Cancer.

Pract Radiat Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH.

Purpose/objective(s): Dosimetric parameters to limit CWT are not well defined in single-fraction stereotactic body radiation therapy (SF-SBRT) phase II trials. We sought to determine the relationship of tumor location and dosimetric parameters with CWT for SF-SBRT.

Materials/methods: From a prospective registry of 1,462 patients, we identified patients treated with 30 Gy or 34 Gy. Read More

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December 2018

Superficial siderosis associated with craniopharyngioma: a rare case report.

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.

Superficial siderosis (SS) associated with craniopharyngioma is an extremely rare occurrence. To our knowledge, only three cases have been reported in literature. Two of the cases occurred following resection of the tumor. Read More

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December 2018

Defining Long-Term clinical outcomes and risks of stereotactic radiosurgery for brainstem cavernous malformations.

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America.

Introduction: We evaluated clinical outcomes in patients with symptomatic brainstem cavernous malformations (CMs) treated by stereotactic radiosurgery (SRS).

Methods: Between 1988 and 2016, Gamma Knife® SRS was performed in 76 evaluable patients with solitary symptomatic brainstem CMs. Forty-nine (66%) were intrinsic (not reaching a pial or ependymal surface). Read More

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December 2018

Seizures after Stereotactic Radiosurgery for Benign Supratentorial Meningiomas: An uncontrollable type of seizure?

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea; Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: We investigated seizure outcomes of patients with supratentorial meningiomas (ST-MNGs) treated with stereotactic radiosurgery (SRS).

Methods: One hundred and thirty-three patients with a total of 144 ST-MNGs, who were treated with SRS between 2009 and 2016, were included in this study. The mean age was 59. Read More

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December 2018

Glioblastoma in a patient with tuberous sclerosis.

J Clin Neurosci 2018 Oct 24. Epub 2018 Oct 24.

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia.

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder with a wide clinical spectrum. The most common brain tumor associated with TSC is the low grade subependymal giant cell astrocytoma. Reports of high grade primary brain tumors in patients with TSC are rare. Read More

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October 2018

Effect of arc length on skin dose from hypofractionated volumetric modulated arc radiotherapy treatments of the lung and spine.

Med Dosim 2018 Dec 4. Epub 2018 Dec 4.

Queensland University of Technology, Brisbane, Queensland 4000, Australia.

Due to large doses per fraction, stereotactic ablative radiotherapy of lung or spine can lead to skin tissue toxicity, the amount of which depends on a variety of factors such as target location, beam geometry, and immobilization. The effect of arc length on spreading out entrance and exit doses and the corresponding predictions of skin reactions has not yet been studied for stereotactic body radiotherapy volumetric modulated arc therapy (VMAT) treatments. 58 clinically relevant VMAT stereotactic body radiotherapy spine and lung plans were created for an anthropomorphic phantom utilizing a range of target locations, beam geometries and arc lengths. Read More

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December 2018

[Cost of radiotherapy for bone metastases in France: A monocentric retrospective study].

Cancer Radiother 2018 Dec 4. Epub 2018 Dec 4.

Département universitaire de radiothérapie, centre Paul-Strauss, Unicancer, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France; Laboratoire EA 3430, fédération de médecine translationnelle de Strasbourg (FMTS), université de Strasbourg, 67000 Strasbourg, France. Electronic address:

Purpose: The cost of radiotherapy is a concern for health systems. The conventional non fractionated or multifractionated schemes have shown the same efficacy in terms of pain relief but a non fractionated treatment seems less expensive. However, in general practice, multifractionated treatments are still the majority, which represents an additional cost for society. Read More

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December 2018

Stereotactic Radiosurgery Versus Whole Brain Radiation Therapy: A Propensity Score Analysis and Predictors of Care for Patients With Brain Metastases From Breast Cancer.

Clin Breast Cancer 2018 Nov 12. Epub 2018 Nov 12.

Department of Radiation Oncology, Baylor College of Medicine, Houston, TX. Electronic address:

Background: Metastases to the brain occur in 10%-16% of patients with breast cancer, with incidence reportedly increasing. Historically, brain metastases (BM) have been treated with whole-brain radiation therapy (WBRT), but stereotactic radiosurgery (SRS) is an increasingly favored treatment option. In this study we used a population-level database to compare patterns of care and survival between WBRT and SRS for BM from breast cancer. Read More

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November 2018

Stereotactic body radiation therapy for stage I non-small cell lung carcinomas: Moderate hypofractionation optimizes outcome.

Lung Cancer 2018 Dec 16;126:201-207. Epub 2018 Nov 16.

Department of Radiotherapy, Centre Paul Strauss, 3, rue de la porte de l'hôpital, BP 42, 67065, Strasbourg cedex, France; Laboratory of Radiobiology, EA 3430, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg University, Strasbourg, France. Electronic address:

Objectives: In case of inoperability or refusal of surgery, stereotactic body radiation therapy (SBRT) is the most effective treatment for a stage I non-small cell lung carcinoma (NSCLC). The results obtained by this irradiation technique are considerably superior to those observed in the time of conventional 3D irradiation and its toxicities are much less important, which makes it possible in elderly patients, or those presenting cardio-pulmonary comorbidities and a poor perfomance status.

Materials And Methods: This study is a retrospective analysis of 90 patients who underwent SBRT for a stage I NSCLC between 2010 and 2015. Read More

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December 2018

Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial).

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

Introduction: Quality of life (QoL) of comorbid patients with pulmonary malignancies is a key issue in considering stereotactic fractionated body radiotherapy (SBRT) indication. This study investigates the early impact of SBRT on QoL.

Methods: 100 patients with pulmonary lesions were treated with SBRT from 02/2011 to 11/2014 within the prospective, monocenter, phase II STRIPE trial. Read More

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December 2018
2 Reads

Evaluating risk factors of radiation pneumonitis after stereotactic body radiation therapy in lung tumor: Meta-analysis of 9 observational studies.

PLoS One 2018 6;13(12):e0208637. Epub 2018 Dec 6.

Department of Oncology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Background: In this study, we assessed the association of SBRT (stereotactic body radiotherapy) dose and volume with radiation pneumonitis (RP) risk in lung tumor.

Methods: Relevant articles were identified up to April 2018, using following databases; Medline, EMBASE, Cochrane Library, and China National Knowledge Infrastructure (CNKI). The pooled OR (odds ratio) with 95% CI (confidence interval) data [mean ± SD (standard deviation)] obtained from different studies was analyzed by statistical analysis using a fixed-effects model or a random-effects model when appropriate. Read More

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December 2018
1 Read

Second infield re-irradiation with a resulting cumulative equivalent dose (EQD2 ) of >180 Gy for patients with recurrent head and neck cancer.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.

Background: For locally recurrent head and neck cancer, re-irradiation with modern techniques like stereotactic body radiotherapy is a promising, possibly curative alternative to palliative systemic therapy.

Methods: We report on 1 patient with nasopharyngeal carcinoma (NPC) and 1 patient with cutaneous squamous cell carcinoma (SCC). Both patients received full dose primary treatment (>66 Gy, EQD2), full dose re-irradiation (>50 Gy, EQD2), and a second course of re-irradiation via robotic radiosurgery (CyberKnife) for a second local recurrence. Read More

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December 2018
3 Reads

Oligometastatic prostate cancer: Reality or figment of imagination.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, Illinois.

The term "oligometastatic prostate cancer" refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Read More

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December 2018
2 Reads

Stereotactic radiofrequency ablation of hepatocellular carcinoma - A histopathological study in explanted livers.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

INNPATH, Institute of Pathology, Tirol Kliniken Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.

Background And Rationale For The Study: This retrospective study was performed to evaluate the efficacy of 3D-navigated multi-probe radiofrequency ablation (RFA) with intraprocedural image fusion for the treatment of hepatocellular carcinoma (HCC) by histopathologic examination.

Main Results: From 2009 to 2018, 97 patients (84 men, 13 women; median age 60 years, range 1 -71) were transplanted after bridging therapy of 195 HCCs by stereotactic RFA (SRFA). The median interval between the first SRFA and transplantation was 6. Read More

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December 2018

Performance of gimbal-based dynamic tumor tracking for treating liver carcinoma.

Radiat Oncol 2018 Dec 5;13(1):242. Epub 2018 Dec 5.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany.

Background: Since the introduction of tumor tracking in radiotherapy, it is possible to ensure a precise irradiation of moving targets. To follow the tumor movement, most systems rely on the detection of implanted markers and correlation models between the internal and external patient movement. This study reports the clinical workflow and first results of the dynamic tumor tracking (DTT) performance for patients with liver carcinoma at the Vero SBRT system of the University Hospital Erlangen regarding the detection of the internal marker and the changes of the determined correlation models. Read More

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December 2018

Study on the Therapeutic Effects of Trigeminal Neuralgia With Microvascular Decompression and Stereotactic Gamma Knife Surgery in the Elderly.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurosurgery, The Second Hospital of Shandong University, Jinan, China.

Objective: The aim of the study was to evaluate the efficacy of microvascular decompression (MVD) and stereotactic gamma knife surgery (GKS) in the treatment of trigeminal neuralgia (TN) in the elderly.

Patients And Methods: Retrospective analysis of 137 elderly cases with TN underwent MVD, partial sensory rhizotomy (PR) treatment from August 2007 to March 2017 and 56 cases underwent GKS treatment from May 2014 to February 2017 was made, compared the efficacy of MVD and GKS in different age groups.

Results: In 125 patients of MVD alone, the responsible vessels included 60 cases of superior cerebellar artery, 55 cases of anterior inferior cerebellar artery, 4 cases of venous vascular compression, 13 cases of mixed arteriovenous compression and 3 cases of vertebral artery, and 2 cases of no responsible vessel. Read More

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November 2018

Contemporary management of juvenile angiofibroma.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 30. Epub 2018 Nov 30.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Purpose Of Review: To illustrate the latest developments and trends in the management of juvenile angiofibroma.

Recent Findings: Endoscopic surgery is currently the primary management strategy for juvenile angiofibroma. Recent reports on the use of multiportal approaches have contributed to further extend its indications. Read More

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November 2018
1 Read

Integral small field output factor measurements using a transmission ionisation chamber.

Australas Phys Eng Sci Med 2018 Nov 30. Epub 2018 Nov 30.

Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia.

Previous studies describe the use of a large area parallel-plate chamber, the PTW Bragg Peak chamber, for measuring dose-area product (DAP) and output factors in small megavoltage photon fields. However, in radiotherapy departments without protons, this detector would have to be purchased separately for this purpose. This work investigated the feasibility of alternatively using a large transmission ionisation chamber, the IBA round Stealth chamber (SC), for output factor measurements of stereotactic fields. Read More

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November 2018

Stereotactic body radiation therapy in primary hepatocellular carcinoma: current status and future directions.

J Gastrointest Oncol 2018 Oct;9(5):858-870

Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA.

Stereotactic body radiation therapy (SBRT) is a form of radiation therapy that has been used in the treatment of primary hepatocellular carcinoma (HCC) over the past decade. To evaluate the clinical efficacy of SBRT in primary HCC, a literature search was conducted to identify original research articles published from January 2000 through January 2018 in PubMed on SBRT in HCC. All relevant studies published from 2004 to 2018 were included. Read More

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October 2018

Early stage lung cancer survival after wedge resection and stereotactic body radiation.

J Thorac Dis 2018 Oct;10(10):5702-5713

Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: The comparative effectiveness of stereotactic body radiation therapy (SBRT) and wedge resection in the treatment of early stage lung cancer is still under debate. This meta-analysis compares the 5-year overall survival (OS) of wedge resection and SBRT in patients with stage I non-small cell lung cancer (NSCLC).

Methods: Original research articles published between 1995 and 2017 were identified through the National Library of Medicine and National Institutes of Health PubMed database and through the reference lists of reviewed articles. Read More

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October 2018

Role of stereotactic radiosurgery in the treatment of acromegaly.

J Pak Med Assoc 2018 Dec;68(12):1843-1845

Department of Surgery, Section of Neurosurgery, Aga Khan University Hospital, Karachi. Pakistan.

Acromegaly is a rare, indolent disease due to overproduction of growth hormone. Surgery is identified as primary treatment, but has its limitation, thus frequently requiring alternate treatment options as adjunct to surgery. Stereotactic radiosurgery (SRS) has been used as adjuvant and alternate therapy in patients with inoperable or residual disease; or those not fit for surgery. Read More

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December 2018
5 Reads

Outcomes of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Severe Cirrhosis and Ineligibility for Transplant.

Anticancer Res 2018 Dec;38(12):6815-6820

Allegheny Health Network, Division of Radiation Oncology, Pittsburgh, PA, U.S.A.

Background/aim: Our study reviewed the results of patients with hepatocellular carcinoma and Child-Pugh score 8-11 cirrhosis treated with stereotactic body radiotherapy when liver transplant was not an option.

Patients And Methods: A retrospective review was performed on 15 patients with Child-Pugh class B and C cirrhosis treated with stereotactic body radiotherapy. The median total dose was 35 Gy in 4-5 fractions. Read More

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December 2018

Adjuvant Systemic Therapy in Patients With Early-Stage Non-Small Cell Lung Cancer (NSCLC) Treated with Stereotactic Body Radiation Therapy (SBRT).

J Thorac Oncol 2018 Nov 29. Epub 2018 Nov 29.

Division of Oncology-Hematology, University of Nebraska Medical Center, Fred and Pamela Buffett Cancer Center, Omaha, NE, USA; Department of Internal Medicine, VA Nebraska Western Iowa Health Care System, Omaha, NE, USA.

Introduction: Stereotactic body radiation therapy (SBRT) is commonly used to treat nonsurgical patients with early-stage NSCLC. There are no prospective data on the role of adjuvant chemotherapy in this setting.

Methods: Patients (≥18 years) diagnosed with clinical stages I-II NSCLC from 2004 to 2013 were identified using the National Cancer Database (n=11,836). Read More

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November 2018
2 Reads

A phase IIb, randomised, double-blind, placebo-controlled, dose-ranging investigation of the safety and efficacy of NTCELL [immunoprotected (alginate-encapsulated) porcine choroid plexus cells for xenotransplantation] in patients with Parkinson's disease.

Parkinsonism Relat Disord 2018 Nov 13. Epub 2018 Nov 13.

Department of Neurology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand; Centre for Brain Research, University of Auckland, New Zealand. Electronic address:

Introduction: Regenerative therapies in Parkinson's disease aim to slow neurodegeneration and re-establish damaged neuronal circuitry. Neurotrophins are potent endogenous regulators of neuronal survival, development and regeneration. They represent an attractive regenerative treatment option in Parkinson's disease. Read More

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November 2018
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Phase I/II trial of helical IMRT-based stereotactic body radiotherapy for hepatocellular carcinoma.

Dig Liver Dis 2018 Nov 17. Epub 2018 Nov 17.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: To report the results of a phase I/II study of helical IMRT-based stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC).

Methods: Eligibility included Child-Turcotte-Pugh class A or B, ≤3 lesions, and cumulative tumor diameter ≤6 cm. Dose was escalated from 36 Gy to 60 Gy delivered in 4 fractions. Read More

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November 2018
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