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Pathogens 2022 May 26;11(6). Epub 2022 May 26.

Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University, IX Wieków Kielc 19A, 25-317 Kielce, Poland.

Background: () is an emerging opportunistic Gram-negative rod causing nosocomial infections predominantly in immunocompromised patients. Due to its broad intrinsic resistance to antibiotics, including carbapenems and the ability to form a biofilm, it is difficult to eradicate.

Methods: In this study, the benefit of combined administration (potential synergism) and anti-biofilm activity of ceragenins: CSA-13, CSA-44, and CSA-131 (synthetic mimics of natural antimicrobial peptides) with ceftazidime, levofloxacin, co-trimoxazole and colistin against clinical strains of were determined using MIC/MBC (minimum inhibitory concentration/minimum bactericidal concentration), killing assays and CV staining. Read More

Antibiotics (Basel) 2022 Jun 7;11(6). Epub 2022 Jun 7.

Food Safety Unit, Department of Agricultural and Food Sciences Alma Mater Studiorum, University of Bologna, 40064 Ozzano dell'Emilia, Italy.

This study is focused on resistance to carbapenems and third-generation cephalosporins in Gram-negative microorganisms isolated from swine, whose transmission to humans via pork consumption cannot be excluded. In addition, the common carriage of carbapenem-resistant (CR) bacteria between humans and pigs was evaluated. Sampling involved 300 faecal samples collected from slaughtered pigs and 300 urine samples collected from 187 hospitalised patients in Parma Province (Italy). Read More

J Hazard Mater 2022 Aug 19;436:129185. Epub 2022 May 19.

LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address:

Musk fragrances have been detected in drinking water (DW) at trace concentrations. However, their impact on the microbial quality of DW has been disregarded. This work provides a pioneer evaluation of the effects of two synthetic musks contaminants, tonalide (AHTN) and galaxolide (HHCB), in microbial biofilms formed on two different surfaces, polyvinyl chloride (PVC) and stainless steel AISI 316 (SS316). Read More

Sci Total Environ 2022 Jun 20:156794. Epub 2022 Jun 20.

Department of Biosciences, School of Sciences, Indrashil University, Rajpur-Kadi, Mehasana, Gujarat, India; Department of Life Sciences, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, Gujarat, India. Electronic address:

The goal of this study was to evaluate the degradation effectiveness of PAHs degrading bacteria at the mesocosm level, including Stenotrophomonas maltophilia (SC), mixed culture (MC), and enriched native microflora (EC) at the mesocosm level. Maximum degradation was found in the mesocosm MC (26.67 %), followed by SC (25. Read More

Microbiol Resour Announc 2022 Jun 23:e0023822. Epub 2022 Jun 23.

Shuyuan Molecular Biology Laboratory, The Independent Schools Foundation Academy, Hong Kong SAR, China.

Stenotrophomonas maltophilia is a widely distributed, Gram-negative bacillus that is increasingly identified as a multidrug-resistant opportunistic pathogen of concern. Here, we report the draft genome sequences of nine strains that were isolated from a freshwater catchment area in Hong Kong, corresponding to four different monophyletic lineages within the species. Read More

J Am Acad Orthop Surg Glob Res Rev 2022 Jun 21;6(6). Epub 2022 Jun 21.

From the Orthopedic Department, Henri Mondor Hospital, Aurillac, France (Deluzarches); the Research & Development Department, I.Ceram, Limoges, France (Poli, and Barriere); and the Infectious Diseases Department, ELSAN Polyclinique de Limoges, Limoges, France (Denes).

To describe the use of a porous alumina ceramic loaded with antibiotics for the reconstruction of bilateral tibial fractures in a patient who presented with bone loss and infection after a motorcycle road injury. A 70-year-old man presented open fractures of his both tibiae (proximal involvement on the right side and diaphyseal on the left side). After initial treatment with multiple débridements and the placement of bilateral external fixators, he had bone loss to both tibiae and had developed infections of both legs with multiple organisms identified (Stenotrophomonas maltophilia, Enterobacter cloacae, and Pseudomonas aeruginosa). Read More

J Chin Med Assoc 2022 Jun 20. Epub 2022 Jun 20.

Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

Background: Coronavirus disease 2019 (COVID-19) inpatients may acquire infections from other pathogens during hospital admission. This is the first research on this subject to be reported from Taiwan.

Methods: Confirmed COVID-19 inpatients were enrolled in this study from January 1, 2020 to July 31, 2021. Read More

Infect Drug Resist 2022 13;15:3039-3046. Epub 2022 Jun 13.

Department of Pulmonary and Critical Care Medicine, Air Force Medical Center, PLA, Beijing, 100142, People's Republic of China.

Background: () is a multidrug-resistant gram-negative bacillus that is known to be an opportunistic pathogen, particularly in a hospital environment. The infection has a high morbidity and mortality. Sulfamethoxazole-trimethoprim (SXT) is the first-line agent recommended for its treatment. Read More

Sci Rep 2022 Jun 18;12(1):10299. Epub 2022 Jun 18.

Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2E9, Canada.

Stenotrophomonas maltophilia is a ubiquitous environmental bacterium capable of causing disease in humans. Antibiotics are largely ineffective against this pathogen due to numerous chromosomally encoded antibiotic resistance mechanisms. An alternative treatment option is phage therapy, the use of bacteriophages to selectively kill target bacteria that are causing infection. Read More

Adv Ther 2022 Jun 14. Epub 2022 Jun 14.

Shionogi Europe, London, UK.

Introduction: Antimicrobial resistance is an urgent medical challenge. In this two-part study, we investigated the epidemiology and management of carbapenem non-susceptible (Carb-NS) Gram-negative bacteria (GNB) in the UK.

Methods: We conducted a retrospective review of data from UK hospitals (ten in part 1, nine in part 2). Read More

Antimicrob Resist Infect Control 2022 Jun 13;11(1):82. Epub 2022 Jun 13.

Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia.

Background: Multidrug resistant organisms (MDROs) occur more commonly in burns patients than in other hospital patients and are an increasingly frequent cause of burn-related mortality. We examined the incidence, trends and risk factors for MDRO acquisition in a specialist burns service housed in an open general surgical ward, and general intensive care unit.

Methods: We performed a retrospective study of adult patients admitted with an acute burn injury to our specialist statewide tertiary burns service between July 2014 and October 2020. Read More

Antimicrob Resist Infect Control 2022 Jun 13;11(1):83. Epub 2022 Jun 13.

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Background: Sepsis due to multidrug resistant (MDR) bacteria is a growing public health problem mainly in low-income countries.

Methods: A multicenter study was conducted between October 2019 and September 2020 at four hospitals located in central (Tikur Anbessa and Yekatit 12), southern (Hawassa) and northern (Dessie) parts of Ethiopia. A total of 1416 patients clinically investigated for sepsis were enrolled. Read More

J Glob Antimicrob Resist 2022 Jun 10. Epub 2022 Jun 10.

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China. Electronic address:

The in vitro antimicrobial activities of sitafloxacin and comparators against 320 clinical isolates of less common nonfermenting Gram-negative bacteria (NFGNB) were assessed by determining the minimum inhibitory concentrations (MICs) using broth microdilution method. In terms of MIC values, sitafloxacin was highly active against Stenotrophomonas maltophilia (0.25/1 mg/L), Burkholderia cepacia complex (0. Read More

Infect Drug Resist 2022 4;15:2901-2914. Epub 2022 Jun 4.

Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Background: Carbapenem-resistant Gram-negative bacteria (CRGNB) bloodstream infection (BSI) pose a significant threat to the prognosis of hematologic malignancies (HM) patients. Understanding the distribution of pathogenic bacteria, changes in carbapenem-resistant trends, risk factors for CRGNB infections, and exploring the early detection measures can help reduce mortality.

Methods: We conducted a multicenter retrospective study of Gram-negative bacteria (GNB) BSI in patients with HM in three university-affiliated hospitals in Hunan Province, China, from January 2010 to December 2020. Read More

J Clin Med 2022 May 30;11(11). Epub 2022 May 30.

Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.

This study aimed to establish the clinical features, outcomes, and factors associated with mortality in patients with  (. ) septicemia. The characteristics and outcome data used in this retrospective study were collected from medical records at Songklanagarind Hospital. Read More

PLoS One 2022 8;17(6):e0267253. Epub 2022 Jun 8.

Department of Plant Pathology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.

Southern blight of tomato caused by Sclerotium rolfsii can cause severe plant mortality and yield losses. The use of rhizobacteria for the biological control of Southern blight disease is a potent alternative to chemical fungicides. Although rhizobacteria are prolific candidates, comprehensive reports regarding their use in tomato disease management are limited. Read More

Environ Res 2022 Sep 4;212(Pt E):113570. Epub 2022 Jun 4.

Jiangsu Provincial Engineering Laboratory for Biomass Conversion and Process Integration, School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai'an, 223003, PR China.

Converting renewable biomass into carbon-neutral biofuels is one of the most effective strategies to achieve zero carbon emissions and contribute to environmental protection. Microorganisms from the soil were primarily screened on the rhodamine B-plate for highly-active lipase producing strains and re-screened on a tributyrin-methanol plate using crude lipases produced from the initially screened-out strains. The lipase-producing strains with higher methanol-tolerant lipase were identified based on morphological characteristics and 16S rDNA sequencing. Read More

Med Intensiva (Engl Ed) 2022 May 31. Epub 2022 May 31.

Unidad de Gestión Clínica de Microbiología, Hospital Universitario Reina Sofía, Departamento de Química Agrícola, Edafología y Microbiología, Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Centro de Investigación en Red de Enfermedades Infecciosas (CIBERINFEC), Spain.

Enterobacterales resistant to carbapenems or producing extended-spectrum β-lactamases (ESBL) and non-fermenters resistant to carbapenems present resistance to many of the antimicrobials commonly used in clinical practice, and have been recognized by the World Health Organization as a critical priority for the development of new antimicrobials. In this review, the main mechanisms of resistance of Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas maltophilia to β-lactams, quinolones, aminoglycosides and polymyxins will be addressed. Updated information will be presented on the importance in resistance of antimicrobial modification mechanisms (including class C or extended-spectrum β-lactamases, carbapenemases and aminoglycoside-modifying enzymes), permeability alterations due to porin or lipopolysaccharide expression disorders, production of active efflux pumps, target alterations or protection, and expression of two-component systems. Read More

Microbiol Spectr 2022 Jun 6:e0032122. Epub 2022 Jun 6.

Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

The hemin acquisition system of Stenotrophomonas maltophilia was elucidated in this study. To identify the TonB-dependent outer membrane receptor for hemin in S. maltophilia, the hemin acquisition systems of Pseudomonas aeruginosa were referenced. Read More

Microbiol Spectr 2022 Jun 1:e0244821. Epub 2022 Jun 1.

Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Stenotrophomonas maltophilia, a nonfermenting Gram-negative rod, is frequently isolated from the environment and is emerging as a multidrug-resistant global opportunistic pathogen. S. maltophilia harbors eight RND-type efflux pumps that contribute to multidrug resistance and physiological functions. Read More

Future Microbiol 2022 Jun 1. Epub 2022 Jun 1.

Department of Microbiology, Saveetha Dental College & Hospitals, Chennai, 600077, India.

, an aerobic, non-fermenting, Gram-negative bacterium, is an emerging nosocomial pathogen. It is considered to be a low-grade pathogen, and infections due to are uncommon. However, in the recent past, infections have been on the rise, particularly in patients who are either immunocompromised, aged or on long-term antibiotic therapy. Read More

J Crit Care 2022 May 27;71:154068. Epub 2022 May 27.

Service de médecine intensive réanimation, hôpital Cochin, AP-HP. CUP, Paris, France; Université de Paris, Paris, France; Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.

Purpose: The objective is to identify the risk markers of multi-drug resistant bacteria (MDRB) related ventilator-associated pneumonia (VAP) in septic shock patients with previous MDRB carriage.

Material And Methods: This retrospective study was conducted in a medical ICU from 2010 to 2020. Consecutive patients with septic shock and still in the ICU after 48 h, were eligible. Read More

Virus Genes 2022 May 28. Epub 2022 May 28.

College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.

Stenotrophomonas maltophilia has been recognized as an emerging global opportunistic pathogen, and it is intrinsically resistant to most antibiotics, which makes the limited choice for treating S. maltophilia infections. Bacteriophage with the proper characterization is considered as a promising alternative treatment option to control S. Read More

J Environ Manage 2022 Sep 24;317:115382. Epub 2022 May 24.

Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, 300191, China. Electronic address:

Organic fertilizer increase antibiotic resistance genes (ARGs) and bacterial pathogens have widely documented. However, how organic fertilizer is involved in changing soil ARGs and pathogenic bacteria after long-term (≥5 years) application remains unclear. Herein, the ARGs and pathogenic bacteria were compared in organic fertilized soils (AF) and non-fertilized soils (NF), and the contribution of input sources (organic fertilizer, irrigation water, air and background soil) on soil ARGs also was determined in this study. Read More

Front Microbiol 2022 10;13:863635. Epub 2022 May 10.

Centro Nacional de Biotecnología, CSIC, Madrid, Spain.

It is generally accepted that fosfomycin activity is higher in the presence of glucose-6-phosphate, since its inducible transporter UhpT is one of the gates for fosfomycin entry. Accordingly, fosfomycin susceptibility tests are performed in the presence of this sugar; however, since lacks UhpT, it is doubtful that glucose-6-phosphate might be a fosfomycin adjuvant in this microorganism. The aim of the work was to determine whether glucose-6-phosphate or other metabolites may alter the activity of fosfomycin against . Read More

Chemosphere 2022 Sep 23;303(Pt 2):135095. Epub 2022 May 23.

School of Minerals Processing and Bioengineering, Central South University, Changsha, Hunan, 410083, PR China.

Heavy metal pollution is consistently a critical global issue, and bioremediation is regarded as one of the most promising approaches. In this work, the biosorption characteristics of Cd(II), Pb(II), Cu(II) and Zn(II) from aqueous solutions using three phosphorus-accumulating organisms (PAOs) biomasses, Ochrobactrum cicero (PAB-006), Stenotrophomonas maltophilia (PAB-009), and Pseudomonas putida (PAB-0031), as biosorbents were investigated. Results indicated that the equilibrium biosorption capacities of biosorbents to heavy metal ions were sensitive to the solution pH, and increased with increasing pH values. Read More

J Cyst Fibros 2022 May 22. Epub 2022 May 22.

Cystic Fibrosis Centre, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: VOCAL was an observational study of the effect of long-term ivacaftor on real-world clinical outcomes and healthcare resource utilization (HCRU) in people with cystic fibrosis (pwCF) in Italy, the Netherlands, and the UK.

Methods: pwCF aged ≥6 years with non-G551D-CFTR gating mutations were eligible. Prospective data were collected up to 48 months after enrollment; retrospective data were collected to ensure that 12 months of pre-ivacaftor data were available. Read More

Klin Lab Diagn 2022 May;67(5):315-320

Pirogov Russian National Research Medical University.

Stenotrophomonas maltophilia is a common opportunistic microorganism and an important respiratory pathogen in cystic fibrosis (CF). The aim of this study was to determine antimicrobial resistance phenotypes, sequence-types (ST) and genetic determinants of antibiotic resistance in S. maltophilia strains recovered from CF patients in Russia. Read More

Front Microbiol 2022 28;13:858546. Epub 2022 Apr 28.

Department of Grassland Science, College of Agronomy, Hunan Agricultural University, Changsha, China.

The objective of this study was to determine the effect of pre-fermented juice, , and . on chemical composition, fermentation, aerobic stability, dynamics of microbial community, and metabolic pathway of a mixture of lucerne, wheat bran (WB), and rice straw (RS). All mixtures were ensiled for 1, 3, 5, 7, 15, 30, and 45 days after treatment with uninoculated (control, C); . Read More

Res Microbiol 2022 May 12:103956. Epub 2022 May 12.

College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address:

Maltocin P28, produced by Stenotrophomonas maltophilia P28, is an R-type phage tail-like bacteriocin (PTLB). Its gene cluster consists of 23 putative genes, including nine nonstructural genes and fourteen structural genes. In this work, three nonstructural genes, mpsA, mpsH and mpsR, were found to encode transcriptional regulators to control maltocin P28 synthesis. Read More