Search Our Scientific Publications & Authors

Mar Biotechnol (NY) 2019 Feb 14. Epub 2019 Feb 14.

Department of Microbiology, Faculty of Pharmacy, University of Granada, 18071, Granada, Spain.

Many Gram-negative aquacultural and agricultural pathogens control virulence factor expression through a quorum-sensing (QS) mechanism involving the production of N-acylhomoserine (AHL) signalling molecules. Thus, the interruption of QS systems by the enzymatic degradation of signalling molecules, known as quorum quenching (QQ), has been proposed as a novel strategy to combat these infections. Given that the symbiotic bacteria of marine invertebrates are considered to be an important source of new bioactive molecules, this study explores the presence of AHL-degrading bacteria among 827 strains previously isolated from the microbiota of anemones and holothurians. Read More

Hemodial Int 2019 Feb 12. Epub 2019 Feb 12.

PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam.

We report a case series of seven patients with nonfermentative Gram-negative bacteria infections in a single dialysis center; four patients with Ralstonia pickettii and three patients with Stenotrophomonas maltophilia. Two of the seven patients were admitted to hospital for intravenous antibiotic treatment, while the rest were treated with oral antibiotics at home. Both the admitted patients had temporary vascular catheter infections from the aforementioned pathogens. Read More

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan

is an organism with a remarkable capacity for drug resistance with several antibiotic resistance determinants in its genome. genome codes for L1 and L2 responsible for intrinsic β-lactam resistance. The Smlt3721 gene (denoted ), located downstream of the gene, encodes an inner membrane protein. Read More

J Cyst Fibros 2018 Oct 25. Epub 2018 Oct 25.

Adult Cystic Fibrosis Centre, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, UK. Electronic address:

Introduction: Stenotrophomonas maltophilia is common in the sputum of people with cystic fibrosis related diabetes (CFRD), raising the question as to whether this is a risk factor for its acquisition. We investigated this at a population level.

Methods: We analysed national Cystic Fibrosis Registry data 2011-2015 for 8047 people with CF > age 6 years, looking at demographics, diagnosis of CFRD, lung function and sputum microbiology; using descriptive and multivariate strategies to establish independent predictors for S. Read More

Klin Lab Diagn 2018 ;63(9):574-578

Samara State Medical University, 43099, Samara, Russia.

The aim of our research was to evaluate the structure and the determination of the phenotypes of antibiotic resistance of microflora isolated from patients' blood in a multidisciplinary hospital during the period from 2013 to 2017. The material was taken into BacT / ALERT bottles containing nutrient media, followed by incubation of blood. In case of a positive result, the material from the vials was dispersed into dense nutrient media. Read More

Infect Dis (Lond) 2019 Feb 7:1-5. Epub 2019 Feb 7.

d Department of Medical Microbiology, Faculty of Medicine , Medical University of Sofia , Sofia , Bulgaria.

Eur J Microbiol Immunol (Bp) 2018 Dec 12;8(4):135-141. Epub 2018 Dec 12.

Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany.

Background: The study assessed a spectrum of previously published in-house fluorescence in-situ hybridization (FISH) probes in a combined approach regarding their diagnostic performance with incubated blood culture materials.

Methods: Within a two-year interval, positive blood culture materials were assessed with Gram and FISH staining. Previously described and new FISH probes were combined to panels for Gram-positive cocci in grape-like clusters and in chains, as well as for Gram-negative rod-shaped bacteria. Read More

Drugs 2019 Feb 2. Epub 2019 Feb 2.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. Read More

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Division of Infectious Diseases, Microbiology and Preventive Medicine, Hospital Universitario Virgen Macarena / Department of Medicine, University of Seville / Biomedicine Institute of Seville (IBiS), Seville, Spain.

Scope: The aim of these guidelines is to provide recommendations for decolonising regimens targeting multidrug-resistant Gram-negative bacteria (MDR-GNB) carriers in all settings.

Methods: These evidence-based guidelines were produced after a systematic review of published studies on decolonisation interventions targeting the following MDR-GNB: third-generation cephalosporin-resistant Enterobacteriaceae (3GCephRE), carbapenem-resistant Enterobacteriaceae (CRE), aminoglycoside-resistant Enterobacteriaceae (AGRE), fluoroquinolone-resistant Enterobacteriaceae (FQRE), extremely drug-resistant Pseudomonas aeruginosa (XDRPA), carbapenem-resistant Acinetobacter baumannii (CRAB), cotrimoxazole-resistant Stenotrophomonas maltophilia (CRSM), colistin-resistant Gram-negative organisms (CoRGNB), pan-drug-resistant Gram-negative organisms (PDRGNB). The recommendations are grouped by MDR-GNB species. Read More

Chest 2019 Jan 24. Epub 2019 Jan 24.

Washington Hospital Center, Washington, DC.

Background: Carbapenem resistance is a growing concern. Applying a novel algorithm, we examined epidemiology and outcomes of carbapenem resistance among gram-negative pathogens in hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP).

Methods: In a retrospective cohort design within the Premier Research database (2009-2016), all hospitalized adult patients with a gram-negative organism in a respiratory or blood culture specimen who fit criteria for HAP/VAP based on International Classification of Diseases, Ninth Revision, Clinical Modification, codes were included in the study. Read More

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, China; Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA, USA. Electronic address:

We report a rare case of culture negative L4-L5 discitis and epidural abscess in an immunocompetent child who had dry cupping therapy performed to treat low back strain. The causative pathogen was identified as Stenotrophomonas maltophilia by shotgun metagenomic sequencing of spinal cord aspirate after more than one month of unsuccessful empirical treatment with 6 different antibiotics. The patient was successfully treated with Sulfamethoxazole-trimethoprim and minocycline. Read More

Mikrobiyol Bul 2019 Jan;53(1):1-11

İnönü University Faculty of Medicine, Department of Biostatistics and Medical Informationt, Malatya, Turkey.

Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) is a new method that is increasingly used in microbiology laboratories due to its ability of reliable and rapid identification (ID) of bacteria and fungi. However, some problems emerge in the routine clinical diagnosis since only one gram-negative selective medium has been suggested up to date. Though EMB agar is one of the traditional gram-negative selective media, there is no data in the scientific literature, about the ID performance of MALDI TOF MS with the gram-negative bacteria grown on this medium. Read More

Plant Dis 2018 Mar 24;102(3):628-639. Epub 2018 Jan 24.

Jiangsu Provincial Anfeng Biogenic Pesticide Engineering Center Co., Ltd.; Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University; Jiangsu Provincial Biogenic Pesticide Engineering Center; and Key Laboratory of Integrated Management of Crop Diseases and Pests, Nanjing Agricultural University.

To identify new bacterial antagonists for cucurbit downy mildew (CDM) caused by Pseudoperonospora cubensis, 163 bacterial isolates were recovered from different microenvironments of field-grown cucumber plants. In the greenhouse, 19 representative isolates were applied to cucumber plants as a foliar spray (FS); 7 isolates achieved the efficacy over 60% against CDM, with 5 (DS22, HS10, DP14, HP4, and DS57) identified as Bacillus pumilus, B. licheniformis, Enterobacter sp. Read More

Biofouling 2019 Jan 21:1-11. Epub 2019 Jan 21.

a LEPABE, Department of Chemical Engineering, Faculty of Engineering , University of Porto , Porto , Portugal.

In this study, 20 heterotrophic bacteria from a minimally processed vegetables (MPV) plant were tested for their susceptibilities to five antibiotics (tetracycline, erythromycin, ampicillin, levofloxacin and ciprofloxacin), their (co)aggregation abilities and their survival under gastric simulated conditions. Peracetic acid (PA) and sodium hypochlorite (SH), both at 50 ppm, were evaluated for their abilities to control biofilms of these bacteria. In general, the Gram-negative bacteria were found to be more resistant to the selected antibiotics. Read More

J Bacteriol 2019 Jan 14. Epub 2019 Jan 14.

Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA

The airway fluids of cystic fibrosis (CF) patients contain local pH gradients and are more acidic than that of healthy indviduals. pH is a critical factor that is often overlooked in studies seeking to recapitulate the infection microenvironment. We sought to determine the impact of pH on the physiology of a ubiqituous yet understudied microbe, Phylogenomics was first used to reconstruct evolutionary relationships between 74 strains of (59 from CF patients). Read More

Can J Microbiol 2019 Jan 11. Epub 2019 Jan 11.

Faculty of Pharmacy, Ain Shams University, African Union Organization St., Abbassia 11566, Cairo, Egypt, Department of Microbiology and Immunology, Cairo, Egypt.

An important microbial resistance mechanism to mercury is its reduction into elemental mercury (facilitated by the merA gene). Thirty eight microbial isolates from a variety of wastewater sources in Egypt were collected. Approximately 14 of these isolates exhibited not only a high degree of tolerance to mercury (up to 160 ppm), but also a high resistance to other tested heavy metals. Read More

PeerJ 2019 3;7:e6102. Epub 2019 Jan 3.

Instituto de Biociencias, Universidad Autónoma de Chiapas, Tapachula, Chiapas, Mexico.

Chitin is the second most abundant organic compound in nature and represents a rich carbon and nitrogen source that is primarily transformed by bacterial communities. Bacteria capable of gradually hydrolyzing chitin into N-acetylglucosamine monomers can have applications in the transformation of residues from shrimp and other crustaceans. The objective of the present study was to isolate, characterize and identify microorganisms with high chitinolytic activity. Read More

PLoS One 2019 8;14(1):e0210201. Epub 2019 Jan 8.

UMR/CNRS 6249 Chrono-Environnement, University of Franche-Comté, Besançon, France.

Pseudomonas aeruginosa is the main cause of chronic airway infection in cystic fibrosis (CF). However, for unclear reasons some patients are never colonized by P. aeruginosa. Read More

Front Microbiol 2018 19;9:3178. Epub 2018 Dec 19.

Environmental Microbiology and Microbial Biotechnology Laboratory, Department of Biotechnology, University of Verona, Verona, Italy.

SeITE02 and sp. MPV1 were isolated from the rhizosphere soil of the selenium-hyperaccumulator legume and waste material from a dumping site for roasted pyrites, respectively. Here, these bacterial strains were studied as cell factories to generate selenium-nanostructures (SeNS) under metabolically controlled growth conditions. Read More

Lupus 2019 Jan 7:961203318821156. Epub 2019 Jan 7.

1 Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory multisystem autoimmune disease that requires multiple differential diagnoses. Munchausen by proxy syndrome (MBPS) is a form of child abuse, where a caregiver intentionally creates a medical history and induces or fabricates signs or disease in a patient. To our knowledge, there is no case report of MBPS mimicking cSLE diagnosis. Read More

J Vet Res 2018 Sep 10;62(3):261-267. Epub 2018 Dec 10.

Department of Fish Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland.

Changes occurring in freshwater ecosystems seem to be fundamental in the development of all microorganisms, including those pathogenic to fish. This has been especially evident in recent years during which dynamic variations in bacterial fish pathology have been observed. Gram-negative bacteria commonly known to be pathogenic to fish, like spp. Read More

Front Microbiol 2018 6;9:2872. Epub 2018 Dec 6.

Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

The massive and irrational use of antibiotics in livestock productions has fostered the occurrence and spread of resistance to "old class antimicrobials." To cope with that phenomenon, some regulations have been already enforced in the member states of the European Union. However, a role of livestock animals in the relatively recent alerts on the rapid worldwide increase of resistance to last-choice antimicrobials as carbapenems is very unlikely. Read More

Front Microbiol 2018 27;9:2850. Epub 2018 Nov 27.

EA 7380 Dynamyc, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est Créteil, Créteil, France.

(Af) and (Sm) are pathogenic microorganisms, which coexist in the respiratory tract of cystic fibrosis (CF) patients. We recently developed an model of mixed biofilm associating Af ATCC 13073-GFP (Af13073) and Sm ATCC 13637 (Sm13637) and described an antibiosis effect. The present study aim was to assess the antibiosis of Sm on Af using different strains and to analyze the potential synergistic virulence of these strains in an model. Read More

Front Microbiol 2018 22;9:2871. Epub 2018 Nov 22.

Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.

The polymyxin antibiotic colistin shows activity against . However, an increased incidence of colistin-resistant isolates has been recently observed. In addition, evaluation of colistin susceptibility for this organism has been problematic. Read More

Mikrobiyol Bul 2018 Oct;52(4):329-339

Haydarpaşa Numune Training and Research Hospital, Department of Medical Microbiology, Istanbul, Turkey.

Empiric treatment with broad-spectrum antibiotics exerts condensed pressure in intensive care units (ICUs) for the selection of multidrug-resistant bacteria. Multidrug-resistant gram-negative bacteria became the focus of interest owing to limited treatment options and negative effects on patient survival. Cumulative antibiograms can guide selection of correct empiric treatment, de-escalation treatment according to antibiogram results and development of policies in fight against antibiotic resistance. Read More

Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.

Curtin Water Quality Research Centre, Curtin University, Perth, Western Australia, Australia.

We report here the complete genome sequence of Stenotrophomonas maltophilia AB550, a multidrug- and solar radiation-resistant strain isolated from the effluents of an urban wastewater treatment plant in Western Australia. The genome consists of a single 4.9-Mb chromosome. Read More

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.

Stenotrophomonas maltophilia is an opportunistic pathogen causing airway infection in people with cystic fibrosis (CF). Here, we report the draft genome sequences of two S. maltophilia strains, AU30115 and AU32848, recovered from CF patients. Read More

J Microbiol Methods 2019 Jan 5;156:52-59. Epub 2018 Dec 5.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Nosocomial infections caused by Stenotrophomonas maltophilia resistant to SXT are increasingly reported worldwide. In this study, a novel melting-curve based multiplex real-time PCR assay for the simultaneous detection of the ssrA and sul1, sul2 and sul3 genes was first established. The assays were performed on a Roche LightCycler® 480 II system. Read More

Front Microbiol 2018 21;9:2809. Epub 2018 Nov 21.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Colistin is one of the last resort antimicrobials for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. After the emergence of transferable colistin resistance genes (-1-5), a reliable culture-based screening method to detect colonization with colistin-resistant Gram-negative bacteria (CRGN) is needed. The objective of this study was to test the performance of SuperPolymyxin™ medium to screen for CRGN in stool samples and to compare different methods for the confirmation of colistin resistance (e. Read More

Front Cell Infect Microbiol 2018 12;8:401. Epub 2018 Nov 12.

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor Darul Ehsan, Malaysia.

is a multi-drug-resistant global opportunistic nosocomial pathogen, which possesses a huge number of virulence factors and antibiotics resistance characteristics. Iron has a crucial contribution toward growth and development, cell growth and proliferation, and pathogenicity. The bacterium found to acquire iron for its cellular process through the expression of two iron acquisition systems. Read More

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):802-808

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

To analyze the distribution and drug resistance of pathogens from the wounds of thermal burn patients, so as to provide reliable basis for the rational use of antibiotics and the effective control over nosocomial infection. Wound samples of 1 310 thermal burn patients admitted into our burn wards from January 2012 to December 2017 were collected and retrospectively analyzed. API bacteria identification panels and automatical bacteria identification equipment were used to identify pathogens. Read More

Plant Mol Biol 2018 12;98(6):579

State Key Laboratory of Tree Genetics and Breeding, Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China.

This article (Zhou et al. 2018) has been retracted by the authors because the sequence BIBAC 002A111F06 was incorrectly assigned to the wrong bacterial species. The BIBAC 002A111F06 sequence (GenBank Accession KC129717) reported in the paper was attributed to Populus euphratica Oliv. Read More

J Arthroplasty 2019 Feb 25;34(2):359-364. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More

Int J Antimicrob Agents 2018 Nov 21. Epub 2018 Nov 21.

International Health Management Associates, Inc., Schaumburg, Illinois, USA.

Cefiderocol (S-649266) is a parenteral siderophore cephalosporin currently in Phase III of clinical development. In this study, we determined the in vitro susceptibility of a 2015-2016 collection of 8,954 clinical isolates of Gram-negative bacilli (GNB), provided by 100 clinical laboratories in North America and Europe, to cefiderocol and comparators using the Clinical and Laboratory Standards Institute broth microdilution method. Iron-depleted cation-adjusted Mueller-Hinton broth was used to test cefiderocol. Read More

Antonie Van Leeuwenhoek 2018 Nov 22. Epub 2018 Nov 22.

Laboratory of Biotechnology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Talat Bang Khen, Lak Si, Bangkok, 10210, Thailand.

Inactivation of ahpC, encoding alkyl hydroperoxide reductase, rendered Stenotrophomonas maltophilia more resistant to HO; the phenotype was directly correlated with enhanced total catalase activity, resulting from an increased level of KatA catalase. Plasmid-borne expression of ahpC from pAhpC could complement all of the mutant phenotypes. Mutagenesis of the proposed AhpC peroxidactic and resolving cysteine residues to alanine (C47A and C166A) on the pAhpC plasmid diminished its ability to complement the ahpC mutant phenotypes, suggesting that the mutagenized ahpC was non-functional. Read More

J Stomatol Oral Maxillofac Surg 2018 Nov 19. Epub 2018 Nov 19.

Recep Tayyip Erdogan University, Department of Pathology, Rize, Turkey.

An 81-year-old woman with diabetes mellitus presented with signs of orbital cellulitis and a gangrenous ulcer on the right palate. Biopsy analysis confirmed a diagnosis of necrotizing fasciitis. Surgical debridement of necrotic tissues and enucleation of the right eye were performed. Read More

Infect Drug Resist 2018 2;11:2047-2061. Epub 2018 Nov 2.

Department for Internal Medicine I/Gastroenterology and Hepatology, University Hospital Frankfurt, Frankfurt am Main, Germany,

Background And Aims: Spontaneous bacterial peritonitis (SBP) is a severe complication of decompensated cirrhosis. The prevalence of multidrug-resistant organisms (MDROs) in patients with cirrhosis is increasing. Identification of patients at risk for SBP due to MDROs (ie, SBP with the evidence of MDROs or in ascitic culture, MDRO-SBP) is crucial to the early adaptation of antibiotic treatment in such patients. Read More

Clin Microbiol Infect 2018 Nov 16. Epub 2018 Nov 16.

Division of Infectious Diseases, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Fluoroquinolones are a popular alternative to trimethoprim-sulfamethoxazole for Stenotrophomonas maltophilia infections.

Objectives: To compare the effects of fluoroquinolones and trimethoprim-sulfamethoxazole on mortality of S. maltophilia infections. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):933-938

Department of ICU, Shexian People's Hospital, Huangshan 245200, Anhui, China (Hu ZC); Department of ICU, First Affiliated Hospital of China University of Science and Technology, Hefei 230001, Anhui, China (Zhou SS). Corresponding author: Zhou Shusheng, Email:

Objective: To investigate the risk factors of ventilator-associated pneumonia (VAP) and the distribution and drug resistance of pathogens in intensive care unit (ICU) of county hospital.

Methods: 234 patients on mechanical ventilation for more than 48 hours admitted to ICU of Shexian People's Hospital of Huangshan City from January 2016 to June 2018 were enrolled. The clinical data of all patients including gender, age, past medical history, exposure to antibiotics, medication, the duration of mechanical ventilation, the length of ICU stay, serum albumin, tracheotomy, re-intubation, prognosis, and pathogenic bacteria and drug sensitivity test of VAP patients were collected. Read More

Eur J Clin Microbiol Infect Dis 2019 Feb 13;38(2):319-323. Epub 2018 Nov 13.

Department of emergency medicine, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

The World Health Organization (WHO) proposed a global priority pathogen list (PPL) of multidrug-resistant (MDR) bacteria. Our current objective was to provide global expert ranking of the most serious MDR bacteria present at intensive care units (ICU) that have become a threat in clinical practice. A proposal addressing a PPL for ICU, arising from the WHO Global PPL, was developed. Read More

Clin Infect Dis 2018 Nov;67(suppl_2):S174-S178

Department of Hematology, Shanghai Jiao Tong University-affiliated Shanghai General Hospital, China.

Background: Bacterial infections are very common among patients with hematological diseases. Scant data are available regarding differences in the epidemiology and biological features of bacterial infections in neutropenic and non-neutropenic patients.

Methods: The aim of this survey was to compare the bacterial pathogens in neutropenic and non-neutropenic patients in the same ward during an 8-year period. Read More

Infect Dis (Lond) 2018 Nov 13:1-11. Epub 2018 Nov 13.

b Department of Medical Microbiology , Faculty of Medicine, Medical University of Sofia , Sofia , Bulgaria.

Stenotrophomonas maltophilia is an increasingly prevalent opportunistic pathogen responsible for a wide range of nosocomial infections in intensive care unit patients, life-threatening diseases in immunocompromised haematology-oncology patients and chronic pulmonary infections in individuals with cystic fibrosis. Therapy of these infections is problematic due to the remarkable intrinsic antimicrobial resistance of the species and to acquired resistance to multiple antimicrobial agents. As this organism is a low-grade pathogen, the pathogenesis of S. Read More

Eur J Clin Microbiol Infect Dis 2019 Feb 12;38(2):285-295. Epub 2018 Nov 12.

Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Hemorrhagic pneumonia (HP) is known as the clinical manifestation of Stenotrophomonas maltophilia infection, while catheter-related blood stream infection (CRBSI) is the common clinical presentation of S. maltophilia bacteremia (SMB). The purpose of this study is to evaluate the risk factors for mortality in hematologic malignancy patients with SMB and to analyze clinical and microbiological characteristics of HP associated with SMB and CRBSI. Read More

Br J Ophthalmol 2018 Nov 12. Epub 2018 Nov 12.

Advanced Eye Center, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Purpose: To study features, management and outcomes of cluster endophthalmitis following intravitreal bevacizumab (BCZ) injection in North India.

Methods: In this retrospective study, 28 patients (23 men) (mean age of 59.07±13 years) who received intravitreal injection of BCZ were included. Read More

Ophthalmic Plast Reconstr Surg 2018 Nov/Dec;34(6):602-603

Int J Antimicrob Agents 2018 Nov 8. Epub 2018 Nov 8.

Texas Tech University Health Sciences Center, Department of Pharmacy Practice, 5920 Forest Park Road, Suite 400, Dallas, TX 75235, USA; VA North Texas Health Care System, 4500 S. Lancaster Road, Dallas, TX 75216, USA; University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.

Piperacillin/tazobactam (TZP) has been associated with nephrotoxicity in patients receiving vancomycin. Its impact on nephrotoxicity in patients with Gram-negative bacteraemia (GNB) is unclear. This study evaluated the impact of TZP on nephrotoxicity in patients with GNB. Read More

Microb Drug Resist 2018 Nov 7. Epub 2018 Nov 7.

Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP) , Ribeirão Preto, Brazil .

Stenotrophomonas maltophilia is an opportunist pathogen that has intrinsic resistance to the majority of antibiotics and has a high ability to adapt in different environments; however, there are few reports of acquired resistance genes in S. maltophilia. The aim of this study was to investigate the antimicrobial resistance profile, the presence of mutations in the quinolone-resistance determining region, the presence of acquired resistance genes, and the different plasmid families in S. Read More

Appl Environ Microbiol 2019 Jan 9;85(2). Epub 2019 Jan 9.

Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain

Joint prosthesis failure is mainly related to aseptic loosening and prosthetic joint infections, both of which are associated with high morbidity and substantial costs for patients and health systems. The development of a biomaterial that is capable of stimulating bone growth while minimizing bacterial adhesion would reduce the incidence of prosthetic failure. We report antibacterial and osteostimulatory effects in a novel fluorine-phosphorus (F-P)-doped TiO oxide film grown on Ti-6Al-4V alloy with a nanostructure of bottle-shaped nanotubes (bNT) using five bacterial species (, , , , and ) and MCT3T3-E1 osteoblastic cells. Read More

Data Brief 2018 Dec 4;21:263-268. Epub 2018 Oct 4.

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamilnadu, India.

is an important emerging nosocomial pathogen with broad level multi-drug resistance. There is a lack of genomic information on to understand the antimicrobial resistance (AMR) mechanism behind. The data article reports on whole genome sequence information of 9 clinical strains isolated from a tertiary care hospital in India. Read More

J Antimicrob Chemother 2019 Feb;74(2):380-386

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

Objectives: We investigated the in vitro activities of cefiderocol, ceftazidime/avibactam, ceftolozane/tazobactam and other related drugs against imipenem-resistant Pseudomonas aeruginosa, imipenem-resistant Acinetobacter baumannii and Stenotrophomonas maltophilia isolates.

Methods: Non-duplicated bacteraemia isolates (n = 300) of imipenem-resistant P. aeruginosa (n = 100), imipenem-resistant A. Read More