1,088 results match your criteria Stem cells translational medicine[Journal]


Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions.

Stem Cells Transl Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Human fibrin hydrogels are a popular choice for use as a biomaterial within tissue engineered constructs because they are biocompatible, nonxenogenic, autologous use compatible, and biodegradable. We have recently demonstrated the ability to culture induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium on fibrin hydrogels. However, iPSCs themselves have relatively few substrate options (e. Read More

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http://dx.doi.org/10.1002/sctm.18-0189DOI Listing
February 2019

In Vivo Formation of Stable Hyaline Cartilage by Naïve Human Bone Marrow Stromal Cells with Modified Fibrin Microbeads.

Stem Cells Transl Med 2019 Feb 14. Epub 2019 Feb 14.

Biotechnology and Radiobiology Laboratory, Hadassah - Hebrew University Medical Center, Sharett Institute of Oncology, Jerusalem, Israel.

Osteoarthritic and other types of articular cartilage defects never heal on their own. Medicinal and surgical approaches are often ineffective, and the supply of autologous chondrocytes for tissue engineering is very limited. Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) have been suggested as an adequate cell source for cartilage reconstruction. Read More

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http://dx.doi.org/10.1002/sctm.18-0129DOI Listing
February 2019

Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age-Related Macular Degeneration.

Stem Cells Transl Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmacology, Physiology, and Neuroscience, Rutgers-New Jersey Medical School, Newark, New Jersey, USA.

Retinal cell therapy can have the objectives of rescue (i.e., modulation of metabolic abnormalities primarily for sight preservation) as well as replacement (i. Read More

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http://dx.doi.org/10.1002/sctm.18-0282DOI Listing
February 2019
1 Read

A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer.

Stem Cells Transl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Animal models show that systemically administered bone marrow-derived mesenchymal stem cells (MSCs) home to sites of primary and metastatic prostate cancer (PC)-making them candidates to selectively deliver cytotoxic agents. To further assess this potential as a cell-based therapeutic vehicle, a phase I study testing homing of systemically infused allogeneic MSCs preprostatectomy was conducted. The primary objective was to assess safety and feasibility and to determine if MSCs accumulate within primary PC tissue. Read More

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http://doi.wiley.com/10.1002/sctm.18-0230
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http://dx.doi.org/10.1002/sctm.18-0230DOI Listing
February 2019
1 Read

Concise Review: Skeletal Muscle as a Delivery Route for Mesenchymal Stromal Cells.

Stem Cells Transl Med 2019 Feb 5. Epub 2019 Feb 5.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.

Mesenchymal stromal cells (MSCs) have demonstrated extensive capacity to modulate a catabolic microenvironment toward tissue repair. The fate, biodistribution, and dwell-time of the in vivo delivered MSCs largely depend on the choice of the cell delivery route. Intramuscular (IM) delivery of MSCs is clinically safe and has been used for the effective treatment of local pathologies. Read More

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http://dx.doi.org/10.1002/sctm.18-0208DOI Listing
February 2019

Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches.

Stem Cells Transl Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Diabetes mellitus (DM) is a common spontaneous endocrine disorder in dogs, which is defined by persistent hyperglycemia and insulin deficiency. Like type 1 diabetes (T1D) in people, canine DM is a complex and multifactorial disease in which genomic and epigenomic factors interact with environmental cues to induce pancreatic β-cell loss and insulin deficiency, although the pathogenesis of canine DM is poorly defined and the role of autoimmunity is further controversial. Both diseases are incurable and require life-long exogenous insulin therapy to maintain glucose homeostasis. Read More

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http://dx.doi.org/10.1002/sctm.18-0163DOI Listing
February 2019
2 Reads

Metabolic Syndrome Interferes with Packaging of Proteins within Porcine Mesenchymal Stem Cell-Derived Extracellular Vesicles.

Stem Cells Transl Med 2019 Feb 1. Epub 2019 Feb 1.

Divisions of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Mesenchymal stem/stromal cells (MSCs) release extracellular vesicles (EVs), which shuttle proteins to recipient cells, promoting cellular repair. We hypothesized that cardiovascular risk factors may alter the pattern of proteins packed within MSC-derived EVs. To test this, we compared the protein cargo of EVs to their parent MSCs in pigs with metabolic syndrome (MetS) and Lean controls. Read More

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http://dx.doi.org/10.1002/sctm.18-0171DOI Listing
February 2019
2 Reads
3.596 Impact Factor

Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improve Motor Symptoms and Normalize Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats.

Stem Cells Transl Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD, treatments are symptomatic and do not halt progression of neurodegeneration. Extracellular vesicles (EVs) can cross the blood-brain barrier and represent promising alternative to the classical treatment strategies. Read More

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http://dx.doi.org/10.1002/sctm.18-0162DOI Listing
February 2019

Allogeneic Ex Vivo Expanded Corneal Epithelial Stem Cell Transplantation: A Randomized Controlled Clinical Trial.

Stem Cells Transl Med 2019 Jan 28. Epub 2019 Jan 28.

Princess Alexandra Eye Pavillion, Edinburgh, United Kingdom.

Limbal stem cell deficiency (LSCD) is a disease resulting from the loss or dysfunction of epithelial stem cells, which seriously impairs sight. Autologous limbal stem cell transplantation is effective in unilateral or partial bilateral disease but not applicable in total bilateral disease. An allogeneic source of transplantable cells for use in total bilateral disease can be obtained from culture of donated cadaveric corneal tissue. Read More

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http://doi.wiley.com/10.1002/sctm.18-0140
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http://dx.doi.org/10.1002/sctm.18-0140DOI Listing
January 2019
1 Read

Mesenchymal Stem Cells from Chronic Pancreatitis Patients Show Comparable Potency Compared To Cells from Healthy Donors.

Stem Cells Transl Med 2019 Jan 24. Epub 2019 Jan 24.

Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Mesenchymal stem cells (MSCs) are proven to be beneficial in islet transplantation, suggesting a potential therapeutic role of them in total pancreatectomy with islet autotransplantation (TP-IAT) for chronic pancreatitis (CP) patients. We investigated whether MSCs derived from CP patients are suitable for use in autologous cell therapy. MSCs from healthy donors (H-MSCs) and CP patients (CP-MSCs) were studied for phenotype, colony formation potential, multilineage differentiation ability, proliferation, senescence, secretory characters, and immunosuppressive functions. Read More

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http://dx.doi.org/10.1002/sctm.18-0093DOI Listing
January 2019
2 Reads

Challenges Toward the Identification of Predictive Markers for Human Mesenchymal Stromal Cells Chondrogenic Potential.

Stem Cells Transl Med 2019 Feb;8(2):194-204

Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Human bone marrow derived mesenchymal stromal cells (BMSCs) represent a putative cell source candidate for tissue engineering-based strategies to repair cartilage and bone. However, traditional isolation of BMSCs by adhesion to plastic leads to very heterogeneous cell populations, accounting for high variability of chondrogenic differentiation outcome, both across donors and across clonally derived strains. Identification of putative surface markers able to select BMSC subpopulations with higher chondrogenic capacity (CC) and reduced variance in chondrogenic differentiation could aid the development of BMSC-based cartilage and bone regeneration approaches. Read More

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http://dx.doi.org/10.1002/sctm.18-0147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344903PMC
February 2019
1 Read

Chondroitin Sulfate Glycosaminoglycan Scaffolds for Cell and Recombinant Protein-Based Bone Regeneration.

Stem Cells Transl Med 2019 Jan 21. Epub 2019 Jan 21.

Regenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.

Bone morphogenetic protein 2 (BMP-2)-loaded collagen sponges remain the clinical standard for treatment of large bone defects when there is insufficient autograft, despite associated complications. Recent efforts to negate comorbidities have included biomaterials and gene therapy approaches to extend the duration of BMP-2 release and activity. In this study, we compared the collagen sponge clinical standard to chondroitin sulfate glycosaminoglycan (CS-GAG) scaffolds as a delivery vehicle for recombinant human BMP-2 (rhBMP-2) and rhBMP-2 expression via human BMP-2 gene inserted into mesenchymal stem cells (BMP-2 MSC). Read More

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http://dx.doi.org/10.1002/sctm.18-0141DOI Listing
January 2019
1 Read

Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier.

Stem Cells Transl Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, California, USA.

Severe corneal injuries often result in permanent vision loss and remain a clinical challenge. Human bone marrow derived mesenchymal stem cells (MSCs) and their secreted factors (secretome) have been studied for their antiscarring, anti-inflammatory, and antiangiogeneic properties. We aimed to deliver lyophilized MSC secretome (MSC-S) within a viscoelastic gel composed of hyaluronic acid (HA) and chondroitin sulfate (CS) as a way to enhance corneal re-epithelialization and reduce complications after mechanical and chemical injuries of the cornea. Read More

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http://doi.wiley.com/10.1002/sctm.18-0178
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http://dx.doi.org/10.1002/sctm.18-0178DOI Listing
January 2019
3 Reads

A Preview of Selected Articles.

Stem Cells Transl Med 2019 Feb 11;8(2):107-109. Epub 2019 Jan 11.

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1002/sctm.18-0296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344900PMC
February 2019
1 Read

Salidroside-Pretreated Mesenchymal Stem Cells Enhance Diabetic Wound Healing by Promoting Paracrine Function and Survival of Mesenchymal Stem Cells Under Hyperglycemia.

Stem Cells Transl Med 2019 Jan 9. Epub 2019 Jan 9.

The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People's Republic of China.

Systematic abnormalities cause several complications in diabetes patients. Impaired wound healing is a serious complication that leads to severe foot ulcer and amputation. Mesenchymal stem cells (MSCs) have been considered a promising strategy for promoting wound healing due to their paracrine function. Read More

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http://doi.wiley.com/10.1002/sctm.18-0143
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http://dx.doi.org/10.1002/sctm.18-0143DOI Listing
January 2019
4 Reads

White Matter Tract Changes Associated with Clinical Improvement in an Open-Label Trial Assessing Autologous Umbilical Cord Blood for Treatment of Young Children with Autism.

Stem Cells Transl Med 2019 Feb 8;8(2):138-147. Epub 2019 Jan 8.

Duke Center for Autism and Brain Development, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by social communication deficits and the presence of restricted interests and repetitive behaviors. We have previously reported significant improvements in behavior, including increased social functioning, improved communication abilities, and decreased clinical symptoms in children with ASD, following treatment with a single infusion of autologous cord blood in a phase I open-label trial. In the current study, we aimed to understand whether these improvements were associated with concurrent changes in brain structural connectivity. Read More

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http://dx.doi.org/10.1002/sctm.18-0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344899PMC
February 2019
2 Reads

Perfluorocarbon Labeling of Human Glial-Restricted Progenitors for F Magnetic Resonance Imaging.

Stem Cells Transl Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

One of the fundamental limitations in assessing potential efficacy in Central Nervous System (CNS) transplantation of stem cells is the capacity for monitoring cell survival and migration noninvasively and longitudinally. Human glial-restricted progenitor (hGRP) cells (Q-Cells) have been investigated for their utility in providing neuroprotection following transplantation into models of amyotrophic lateral sclerosis (ALS) and have been granted a Food and Drug Administration (FDA) Investigational New Drug (IND) for intraspinal transplantation in ALS patients. Furthermore, clinical development of these cells for therapeutic use will rely on the ability to track the cells using noninvasive imaging methodologies as well as the verification that the transplanted GRPs have disease-relevant activity. Read More

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http://doi.wiley.com/10.1002/sctm.18-0094
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http://dx.doi.org/10.1002/sctm.18-0094DOI Listing
January 2019
2 Reads

Concise Review: Therapeutic Potential of the Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Radiation-Induced Lung Injury: Progress and Hypotheses.

Stem Cells Transl Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.

Radiation-induced lung injury (RILI) is a common complication in radiotherapy of thoracic tumors and limits the therapeutic dose of radiation that can be given to effectively control tumors. RILI develops through a complex pathological process, resulting in induction and activation of various cytokines, infiltration by inflammatory cells, cytokine-induced activation of fibroblasts, and subsequent tissue remodeling by activated fibroblasts, ultimately leading to impaired lung function and respiratory failure. Increasing evidence shows that mesenchymal stem cells (MSCs) may play a main role in modulating inflammation and immune responses, promoting survival and repair of damaged resident cells and enhancing regeneration of damaged tissue through soluble paracrine factors and therapeutic extracellular vesicles. Read More

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http://doi.wiley.com/10.1002/sctm.18-0038
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http://dx.doi.org/10.1002/sctm.18-0038DOI Listing
January 2019
4 Reads
3.596 Impact Factor

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial.

Stem Cells Transl Med 2018 Dec 28. Epub 2018 Dec 28.

Cells for Cells & Consorcio Regenero, Santiago, Chile.

Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement in focal or diffuse disease. This study aimed to assess the safety and efficacy of the intra-articular injection of single or repeated umbilical cord-derived (UC) MSCs in knee OA. Read More

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http://dx.doi.org/10.1002/sctm.18-0053DOI Listing
December 2018
3 Reads

Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations.

Stem Cells Transl Med 2018 Dec 26. Epub 2018 Dec 26.

State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, Fourth Military Medical University, Xi'an, People's Republic of China.

Periodontitis is a widespread disease characterized by inflammation-induced progressive damage to the tooth-supporting structures until tooth loss occurs. The regeneration of lost/damaged support tissue in the periodontium, including the alveolar bone, periodontal ligament, and cementum, is an ambitious purpose of periodontal regenerative therapy and might effectively reduce periodontitis-caused tooth loss. The use of stem cells for periodontal regeneration is a hot field in translational research and an emerging potential treatment for periodontitis. Read More

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http://dx.doi.org/10.1002/sctm.18-0181DOI Listing
December 2018
2 Reads
3.596 Impact Factor

Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells-Ready for Take-Off.

Stem Cells Transl Med 2018 Dec 26. Epub 2018 Dec 26.

Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.

Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have opened up a world of possibilities for regenerative medicine and novel cell-based therapeutics. Now, over a decade later, robust reprogramming and expansion and differentiation protocols have been developed, and iPSC-derived cells have been used in a wide variety of small and large animal models to treat many different diseases. Furthermore, the first iPSC derivatives are on their way into clinical trials. Read More

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http://dx.doi.org/10.1002/sctm.18-0134DOI Listing
December 2018
1 Read

Protective Effects of Uncultured Adipose-Derived Stromal Vascular Fraction on Testicular Injury Induced by Torsion-Detorsion in Rats.

Stem Cells Transl Med 2018 Dec 19. Epub 2018 Dec 19.

Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Torsion-detorsion (T/D)-induced testicular injury may lead to male subfertility and even infertility. Stem cell therapy provides an alternative to attenuate testicular injury and promote spermatogenesis. Adipose-derived stromal vascular fraction (SVF) can be acquired conveniently without in vitro expansion, which may avoid the potential risks of microbial contamination, xenogenic nutritional sources, etc. Read More

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http://dx.doi.org/10.1002/sctm.18-0063DOI Listing
December 2018
3 Reads

A Preview of Selected Articles.

Stem Cells Transl Med 2019 Jan 13;8(1):1-3. Epub 2018 Dec 13.

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1002/sctm.18-0277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312438PMC
January 2019
1 Read

A Comprehensive Analysis of Protocols for Deriving Dopaminergic Neurons from Human Pluripotent Stem Cells.

Stem Cells Transl Med 2018 Dec 10. Epub 2018 Dec 10.

Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, USA.

The potential applications of human embryonic and induced pluripotent stem cells has led to immense interest in developing new protocols to differentiate specific cell types or modifying existing protocols. To investigate to what extent and why new protocols for the same cell types are developed and adopted, we systematically evaluated 158 publications (2004-2017) that differentiated human stem cells into dopaminergic neurons. We categorized each article by degree of novelty and recorded motivations for protocol development. Read More

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http://dx.doi.org/10.1002/sctm.18-0088DOI Listing
December 2018
1 Read

Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair.

Stem Cells Transl Med 2018 Dec 11. Epub 2018 Dec 11.

The Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano-, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/sctm.18-0155
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http://dx.doi.org/10.1002/sctm.18-0155DOI Listing
December 2018
7 Reads

Myotubes Formed De Novo by Myoblasts Injected into the Scar of Myocardial Infarction Persisted for 16 Years in a Patient: Importance for Regenerative Medicine in Degenerative Myopathies.

Stem Cells Transl Med 2018 Dec 1. Epub 2018 Dec 1.

Axe Neurosciences, Research Center of the CHU de Quebec-CHUL, Quebec, Canada.

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http://doi.wiley.com/10.1002/sctm.18-0202
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http://dx.doi.org/10.1002/sctm.18-0202DOI Listing
December 2018
7 Reads
3.596 Impact Factor

Cell Therapy for Cystic Fibrosis Lung Disease: Regenerative Basal Cell Amplification.

Stem Cells Transl Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.

The human airway epithelium is regenerated by basal cells. Thus, basal cell therapy has the potential to cure cystic fibrosis (CF) lung disease. We previously reported that the human basal cells repopulated the mouse airway epithelium after transplantation, and we estimated that 60 million cells would be needed to treat a human patient. Read More

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http://dx.doi.org/10.1002/sctm.18-0098DOI Listing
December 2018
2 Reads

A Preview of Selected Articles.

Stem Cells Transl Med 2018 Dec;7(12):839-841

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1002/sctm.18-0241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265628PMC
December 2018
1 Read

Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.

Stem Cells Transl Med 2018 Nov 28. Epub 2018 Nov 28.

Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

Tumorigenesis is an important problem that needs to be addressed in the field of human stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI). When certain "tumorigenic" cell lines are transplanted into the spinal cord of SCI mice model, there is initial improvement of motor function, followed by abrupt deterioration secondary to the effect of tumor growth. A significant proportion of the transplanted cells remains undifferentiated after transplantation and is thought to increase the risk of tumorigenesis. Read More

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http://dx.doi.org/10.1002/sctm.18-0096DOI Listing
November 2018
4 Reads

Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications.

Stem Cells Transl Med 2018 Nov 26. Epub 2018 Nov 26.

Department of Physiology, Pusan National University School of Medicine, Yangsan, Republic of Korea.

Circulating angiogenic cells (CACs) have been implicated in the repair of ischemic tissues, and their mobilization from bone marrow is known to be regulated by the activations of chemokine receptors, including CXCR2 and CXCR4. This study was conducted to investigate the role of N-acetylated proline-glycine-proline (Ac-PGP; a collagen-derived chemotactic tripeptide) on CAC mobilization and its therapeutic potential for the treatment of peripheral artery diseases. Ac-PGP was administered daily to a murine hind limb ischemia model, and the effects of Ac-PGP on blood perfusion and CAC mobilization (Sca1 Flk1 cells) into peripheral blood were assessed. Read More

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http://dx.doi.org/10.1002/sctm.18-0035DOI Listing
November 2018
1 Read

Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification.

Stem Cells Transl Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Stem Cell Biology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Human induced pluripotent stem cells (hiPSCs) are an important tool for research and regenerative medicine, but their efficient cryopreservation remains a major challenge. The current gold standard is slow-rate freezing of dissociated colonies in suspension, but low recovery rates limit immediate post-thawing applicability. We tested whether ultrafast cooling by adherent vitrification improves post-thawing survival in a selection of hiPSCs and small molecule neural precursor cells (smNPCs) from Parkinson's disease and controls. Read More

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http://doi.wiley.com/10.1002/sctm.18-0121
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http://dx.doi.org/10.1002/sctm.18-0121DOI Listing
November 2018
9 Reads

Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy.

Stem Cells Transl Med 2019 Feb 19;8(2):124-137. Epub 2018 Nov 19.

Centre for Stem Cells and Regenerative Medicine, King's College London, London, United Kingdom.

Recent advancements in the production of hepatocytes from human pluripotent stem cells (hPSC-Heps) afford tremendous possibilities for treatment of patients with liver disease. Validated current good manufacturing practice (cGMP) lines are an essential prerequisite for such applications but have only recently been established. Whether such cGMP lines are capable of hepatic differentiation is not known. Read More

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http://doi.wiley.com/10.1002/sctm.18-0084
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http://dx.doi.org/10.1002/sctm.18-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344902PMC
February 2019
7 Reads

Mesenchymal Stem Cell Administration Attenuates Colon Cancer Progression by Modulating the Immune Component within the Colorectal Tumor Microenvironment.

Stem Cells Transl Med 2018 Nov 19. Epub 2018 Nov 19.

Radiobiology of Medical Exposure Laboratory (LRMed), Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France.

We here determine the influence of mesenchymal stem cell (MSC) therapy on the progression of solid tumors. The influence of MSCs was investigated in human colorectal cancer cells as well as in an immunocompetent rat model of colorectal carcinogenesis representative of the human pathology. Treatment with bone marrow (BM)-derived MSCs significantly reduced both cancer initiation and cancer progression by increasing the number of tumor-free animals as well as decreasing the number and the size of the tumors by half, thereby extending their lifespan. Read More

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http://doi.wiley.com/10.1002/sctm.18-0117
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http://dx.doi.org/10.1002/sctm.18-0117DOI Listing
November 2018
12 Reads
3.596 Impact Factor

HDAC8, A Potential Therapeutic Target, Regulates Proliferation and Differentiation of Bone Marrow Stromal Cells in Fibrous Dysplasia.

Stem Cells Transl Med 2019 Feb 13;8(2):148-161. Epub 2018 Nov 13.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.

Fibrous dysplasia (FD) is a disease of postnatal skeletal stem cells caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS). FD is characterized by high proliferation and osteogenesis disorder of bone marrow stromal cells (BMSCs), resulting in bone pain, deformities, and fractures. The cAMP-CREB pathway, which is activated by GNAS mutations, is known to be closely associated with the occurrence of FD. Read More

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http://doi.wiley.com/10.1002/sctm.18-0057
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http://dx.doi.org/10.1002/sctm.18-0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344909PMC
February 2019
11 Reads

Serum from Asthmatic Mice Potentiates the Therapeutic Effects of Mesenchymal Stromal Cells in Experimental Allergic Asthma.

Stem Cells Transl Med 2018 Nov 13. Epub 2018 Nov 13.

Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Asthma is a chronic inflammatory disease characterized by airway inflammation and remodeling, which can lead to progressive decline of lung function. Although mesenchymal stromal cells (MSCs) have shown beneficial immunomodulatory properties in preclinical models of allergic asthma, effects on airway remodeling have been limited. Mounting evidence suggests that prior exposure of MSCs to specific inflammatory stimuli or environments can enhance their immunomodulatory properties. Read More

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http://doi.wiley.com/10.1002/sctm.18-0056
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http://dx.doi.org/10.1002/sctm.18-0056DOI Listing
November 2018
10 Reads

Perils and Promises of Therapeutic Approaches for the Stem Cell Disease Fibrous Dysplasia.

Authors:
Isabella Saggio

Stem Cells Transl Med 2019 Feb 13;8(2):110-111. Epub 2018 Nov 13.

Department of Biology and Biotechnology, Sapienza University, Rome, Italy and Nanyang Technological University, Singapore.

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http://dx.doi.org/10.1002/sctm.18-0213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344905PMC
February 2019
2 Reads

Concise Review: Lessons Learned from Islet Transplant Clinical Trials in Developing Stem Cell Therapies for Type 1 Diabetes.

Stem Cells Transl Med 2018 Nov 12. Epub 2018 Nov 12.

Seraxis Inc., Germantown, Maryland, USA.

We examined data and patterns in clinical islet transplant studies registered on clinicaltrials.gov (CTgov) for treatment of type 1 diabetes (T1D), with a goal of extracting insights to apply in the design of a pluripotent stem cell-derived islet therapy. Clinical islet transplantation, as a cell therapy (rather than solid organ transplant) is a unique precedent for stem cell-based islet therapies. Read More

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http://doi.wiley.com/10.1002/sctm.18-0156
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http://dx.doi.org/10.1002/sctm.18-0156DOI Listing
November 2018
10 Reads

Transplantation of Olfactory Stem Cells with Biodegradable Hydrogel Accelerates Facial Nerve Regeneration After Crush Injury.

Stem Cells Transl Med 2019 Feb 12;8(2):169-178. Epub 2018 Nov 12.

Department of Otolaryngology, Head & Neck Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan.

Olfactory mucosa contains neural stem cells, called olfactory stem cells (OSCs), which produce trophic support required for promoting axonal regeneration after nerve injury. However, the local tissue environment can reduce the viability/function of transplanted cells when placed directly on the injury. Although gelatin hydrogels have been shown to aid cell survival during transplantation, such OSC-hydrogel combinations have not been extensively tested, particularly during recovery from facial nerve palsy. Read More

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http://doi.wiley.com/10.1002/sctm.15-0399
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http://dx.doi.org/10.1002/sctm.15-0399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344901PMC
February 2019
10 Reads

Regenology: Time for a New Specialty?

Stem Cells Transl Med 2019 Jan 9;8(1):4-6. Epub 2018 Nov 9.

Wake Forest Institute for Regenerative Medicine, Winston Salem, North Carolina, USA.

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http://dx.doi.org/10.1002/sctm.18-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312441PMC
January 2019
1 Read

Stem Cells Translational Medicine.

Stem Cells Transl Med 2018 Jul;7(7):503-505

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1002/sctm.18-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052606PMC
July 2018
2 Reads

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice.

Stem Cells Transl Med 2018 Nov 5. Epub 2018 Nov 5.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

We describe a novel therapeutic approach for cirrhosis using mesenchymal stem cells (MSCs) and colony-stimulating factor-1-induced bone marrow-derived macrophages (id-BMMs) and analyze the mechanisms underlying fibrosis improvement and regeneration. Mouse MSCs and id-BMMs were cultured from mouse bone marrow and their interactions analyzed in vitro. MSCs, id-BMMs, and a combination therapy using MSCs and id-BMMs were administered to mice with CCl -induced cirrhosis. Read More

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http://doi.wiley.com/10.1002/sctm.18-0105
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http://dx.doi.org/10.1002/sctm.18-0105DOI Listing
November 2018
18 Reads

Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium.

Stem Cells Transl Med 2019 Feb 4;8(2):179-193. Epub 2018 Nov 4.

Faculty of Biomedical Sciences and Engineering, BioMediTech, Tampere University of Technology, Tampere, Finland.

Retinal pigment epithelium (RPE) performs important functions for the maintenance of photoreceptors and vision. Malfunctions within the RPE are implicated in several retinal diseases for which transplantations of stem cell-derived RPE are promising treatment options. Their success, however, is largely dependent on the functionality of the transplanted cells. Read More

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http://doi.wiley.com/10.1002/sctm.18-0026
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http://dx.doi.org/10.1002/sctm.18-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344904PMC
February 2019
9 Reads

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons.

Stem Cells Transl Med 2019 Feb 1;8(2):112-123. Epub 2018 Nov 1.

Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, Maryland, USA.

Proneural transcription factors (TFs) drive highly efficient differentiation of pluripotent stem cells to lineage-specific neurons. However, current strategies mainly rely on genome-integrating viruses. Here, we used synthetic mRNAs coding two proneural TFs (Atoh1 and Ngn2) to differentiate induced pluripotent stem cells (iPSCs) into midbrain dopaminergic (mDA) neurons. Read More

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http://doi.wiley.com/10.1002/sctm.18-0036
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http://dx.doi.org/10.1002/sctm.18-0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344911PMC
February 2019
14 Reads

Immunosuppression Agent Cyclosporine Reduces Self-Renewal and Vessel Regeneration Potentiation of Human Endothelial Colony Forming Cells.

Stem Cells Transl Med 2019 Feb 13;8(2):162-168. Epub 2018 Oct 13.

UQ Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia.

Endothelial colony forming cells (ECFC) and mesenchymal stem cells (MSC) combined have great potential to be used for cell therapy of ischemic vascular diseases. However, to improve allogeneic stem cell engraftment the use of immunosuppression, such as cyclosporine has been suggested. Our aim was to assess the impact of cyclosporine on hind limb revascularisation upon MSC and ECFC combination therapy. Read More

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http://doi.wiley.com/10.1002/sctm.18-0103
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http://dx.doi.org/10.1002/sctm.18-0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344910PMC
February 2019
15 Reads

Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success.

Stem Cells Transl Med 2019 Jan 17;8(1):75-81. Epub 2018 Oct 17.

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing preclinical and clinical efforts to therapeutically target these cells and improve patient outcomes. Read More

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http://dx.doi.org/10.1002/sctm.18-0123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312440PMC
January 2019
1 Read
3.600 Impact Factor

A Preview of Selected Articles.

Stem Cells Transl Med 2018 Nov 15;7(11):759-761. Epub 2018 Oct 15.

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1002/sctm.18-0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216421PMC
November 2018
1 Read

A Preview of Selected Articles.

Stem Cells Transl Med 2018 Oct;7(10):699-701

Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://doi.wiley.com/10.1002/sctm.18-0194
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http://dx.doi.org/10.1002/sctm.18-0194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186270PMC
October 2018
6 Reads

Different Effects of Pro-Inflammatory Factors and Hyperosmotic Stress on Corneal Epithelial Stem/Progenitor Cells and Wound Healing in Mice.

Stem Cells Transl Med 2019 Jan 9;8(1):46-57. Epub 2018 Oct 9.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, People's Republic of China.

Chronic inflammation and severe dry eye are two important adverse factors for the successful transplant of cultured limbal stem cells. The aim of this study was to investigate the effects of inflammation and hyperosmotic stress (a key pathological factor in dry eye) on corneal epithelial stem cells (CESCs) and corneal epithelial wound healing. We observed that the CESCs exhibited significant morphological changes when treated with interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), or hyperosmotic stress. Read More

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http://dx.doi.org/10.1002/sctm.18-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312447PMC
January 2019
2 Reads

Concise Review: The Current State of Human In Vitro Cardiac Disease Modeling: A Focus on Gene Editing and Tissue Engineering.

Stem Cells Transl Med 2019 Jan 9;8(1):66-74. Epub 2018 Oct 9.

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, RB, The Netherlands.

Until recently, in vivo and ex vivo experiments were the only means to determine factors and pathways involved in disease pathophysiology. After the generation of characterized human embryonic stem cell lines, human diseases could readily be studied in an extensively controllable setting. The introduction of human-induced pluripotent stem cells, a decade ago, allowed the investigation of hereditary diseases in vitro. Read More

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http://doi.wiley.com/10.1002/sctm.18-0052
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http://dx.doi.org/10.1002/sctm.18-0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312446PMC
January 2019
3 Reads