1,650 results match your criteria Stem cells international[Journal]


Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering.

Stem Cells Int 2019 13;2019:9671206. Epub 2019 Jan 13.

Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma War Injuries, PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.

The inflammatory response to chronic injury affects tissue regeneration and has become an important factor influencing the prognosis of patients. In previous stem cell treatments, it was revealed that stem cells not only have the ability for direct differentiation or regeneration in chronic tissue damage but also have a regulatory effect on the immune microenvironment. Stem cells can regulate the immune microenvironment during tissue repair and provide a good "soil" for tissue regeneration. Read More

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http://dx.doi.org/10.1155/2019/9671206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350611PMC
January 2019

Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair.

Stem Cells Int 2019 15;2019:9310318. Epub 2019 Jan 15.

Laboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, Universites of Paris-Descartes, Pierre and Marie Curie and Paris-Diderot, 15 rue de l'école de médecine, Paris, France.

A large array of therapeutic procedures is available to treat cartilage disorders caused by trauma or inflammatory disease. Most are invasive and may result in treatment failure or development of osteoarthritis due to extensive cartilage damage from repeated surgery. Despite encouraging results of early cell therapy trials that used chondrocytes collected during arthroscopic surgery, these approaches have serious disadvantages, including morbidity associated with cell harvesting and low predictive clinical outcomes. Read More

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http://dx.doi.org/10.1155/2019/9310318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350557PMC
January 2019

Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy.

Stem Cells Int 2019 13;2019:8387350. Epub 2019 Jan 13.

Transplantation Center of The 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.

Renal fibrosis, as the fundamental pathological process of chronic kidney disease (CKD), is a pathologic extension of the normal wound healing process characterized by endothelium injury, myofibroblast activation, macrophage migration, inflammatory signaling stimulation, matrix deposition, and remodelling. Yet, the current method of treating renal fibrosis is fairly limited, including angiotensin-converting enzyme inhibition, angiotensin receptor blockade, optimal blood pressure control, and sodium bicarbonate for metabolic acidosis. MSCs are pluripotent adult stem cells that can differentiate into various types of tissue lineages, such as the cartilage (chondrocytes), bone (osteoblasts), fat (adipocytes), and muscle (myocytes). Read More

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https://www.hindawi.com/journals/sci/2019/8387350/
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http://dx.doi.org/10.1155/2019/8387350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350586PMC
January 2019
3 Reads

Osteoarthritic Synovial Fluid Modulates Cell Phenotype and Metabolic Behavior .

Stem Cells Int 2019 15;2019:8169172. Epub 2019 Jan 15.

Research Division, National Institute of Traumatology and Orthopedics Jamil Haddad, Rio de Janeiro, RJ, Brazil.

Synovial fluid holds a population of mesenchymal stem cells (MSC) that could be used for clinical treatment. Our goal was to characterize the inflammatory and metabolomic profile of the synovial fluid from osteoarthritic patients and to identify its modulatory effect on synovial fluid cells. Synovial fluid was collected from non-OA and OA patients, which was centrifuged to isolate cells. Read More

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https://www.hindawi.com/journals/sci/2019/8169172/
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http://dx.doi.org/10.1155/2019/8169172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350599PMC
January 2019
4 Reads

Environmental Benzopyrene Attenuates Stemness of Placenta-Derived Mesenchymal Stem Cells via Aryl Hydrocarbon Receptor.

Stem Cells Int 2019 13;2019:7414015. Epub 2019 Jan 13.

Department of Biomedical Laboratory Science, College of Health Science, Jungwon University, Chung-buk 28024, Republic of Korea.

The toxic effects of particulate matter have been linked to polycyclic aromatic hydrocarbons (PAHs) such as benzopyrene. PAHs are potent inducers of the aryl hydrocarbon receptor (AhR), which is an expressed nuclear receptor that senses environmental stimuli and modulates gene expression. Even though several studies have shown that the benzopyrene (BP) of chemical pollutants significantly impaired stem cell activity, the exact molecular mechanisms were not clearly elucidated. Read More

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https://www.hindawi.com/journals/sci/2019/7414015/
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http://dx.doi.org/10.1155/2019/7414015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350590PMC
January 2019
1 Read

Serum-Free Manufacturing of Mesenchymal Stem Cell Tissue Rings Using Human-Induced Pluripotent Stem Cells.

Stem Cells Int 2019 15;2019:5654324. Epub 2019 Jan 15.

Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse NY 13244, USA.

Combination of stem cell technology and 3D biofabrication approaches provides physiological similarity to tissues and the capability of repairing and regenerating damaged human tissues. Mesenchymal stem cells (MSCs) have been widely used for regenerative medicine applications because of their immunosuppressive properties and multipotent potentials. To obtain large amount of high-quality MSCs without patient donation and invasive procedures, we differentiated MSCs from human-induced pluripotent stem cells (hiPSC-MSCs) using serum-free E6 media supplemented with only one growth factor (bFGF) and two small molecules (SB431542 and CHIR99021). Read More

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http://dx.doi.org/10.1155/2019/5654324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350554PMC
January 2019

Oral Plaque from Type 2 Diabetic Patients Reduces the Clonogenic Capacity of Dental Pulp-Derived Mesenchymal Stem Cells.

Stem Cells Int 2019 14;2019:1516746. Epub 2019 Jan 14.

Department of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, C.so della Repubblica 79, 04100 Latina, Italy.

Type 2 diabetes (T2D) is a major metabolic disease and a key epigenetic risk factor for the development of additional clinical complications. Among them, periodontitis (PD), a severe inflammatory disease ascribable to a dysregulated physiology and composition of the oral microbiota, represents one of the most relevant complications. Periodontitis can impact the structure of the tooth and likely the stem and progenitor cell pool, which actively contributes to the periodontal microenvironment and homeostasis. Read More

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http://dx.doi.org/10.1155/2019/1516746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348930PMC
January 2019

Titanium Surface Properties Influence the Biological Activity and FasL Expression of Craniofacial Stromal Cells.

Stem Cells Int 2019 13;2019:4670560. Epub 2019 Jan 13.

Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Mesenchymal stromal cells (MSCs) can be easily isolated form craniofacial bones during routine dentistry procedures. Due to their embryological origin from neural crest, they represent a suitable cell population to study cell-biomaterial interaction in the craniofacial field, including osteoinductive/osteointegrative processes. The biological and immunomodulatory properties of MSCs may be influenced by chemistry and topography of implant surfaces. Read More

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http://dx.doi.org/10.1155/2019/4670560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348805PMC
January 2019
1 Read

Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells.

Stem Cells Int 2019 13;2019:3904645. Epub 2019 Jan 13.

Laboratory of Cellular and Molecular Cardiology, Cardiocentro Ticino, Lugano, Switzerland.

Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic acid (RA) and other molecular regulators of cellular function. Over the past decade, high ALDH activity has been increasingly used as a selectable marker for normal cell populations enriched in stem and progenitor cells, as well as for cell populations from cancer tissues enriched in tumor-initiating stem-like cells. Mounting evidence suggests that ALDH not only may be used as a marker for stem cells but also may well regulate cellular functions related to self-renewal, expansion, differentiation, and resistance to drugs and radiation. Read More

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https://www.hindawi.com/journals/sci/2019/3904645/
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http://dx.doi.org/10.1155/2019/3904645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348814PMC
January 2019
3 Reads

Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head.

Stem Cells Int 2019 8;2019:8914569. Epub 2019 Jan 8.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.

The last couple of decades have seen brilliant progress in stem cell therapies, including native, genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phenotype maintenance and/or differentiation towards osteogenic lineage. The preclinical and clinical outcomes accelerate the clinical translation. Read More

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http://dx.doi.org/10.1155/2019/8914569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341242PMC
January 2019
1 Read

Amifostine Suppresses the Side Effects of Radiation on BMSCs by Promoting Cell Proliferation and Reducing ROS Production.

Stem Cells Int 2019 9;2019:8749090. Epub 2019 Jan 9.

Dental Implant Center, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

This study is aimed at investigating the effect of amifostine (AMI) on rat bone marrow stromal stem cells (BMSCs) exposed to 2 Gy radiation. The BMSCs were divided into four groups, namely, group A that received 0 Gy radiation, group B that received 0 Gy radiation and AMI, group C that received 2 Gy radiation, and group D that received 2 Gy radiation and AMI. The proliferation, apoptosis, and distribution of BMSCs in the cell cycle, along with their osteogenesis ability, adipogenesis ability, and ROS production, were subsequently examined. Read More

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https://www.hindawi.com/journals/sci/2019/8749090/
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http://dx.doi.org/10.1155/2019/8749090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343176PMC
January 2019
5 Reads

Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study.

Stem Cells Int 2019 9;2019:4351327. Epub 2019 Jan 9.

Experimental Surgery and Regenerative Medicine (ExperiMed), Ludwig-Maximilians University, Munich 80336, Germany.

Bisphosphonates (BPs) are the keystone to treat bone disorders. Despite the great benefits of BPs, medication-related osteonecrosis of the jaw (MRONJ) arouse as a potential side effect. Nitrogen-containing BPs (N-BPs) as zoledronate (ZA) act by the inhibition of specific enzymes of the mevalonate pathway resulting in altering protein prenylation which is required for the posttranslational maturation of the small GTP-binding proteins. Read More

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http://dx.doi.org/10.1155/2019/4351327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343170PMC
January 2019
1 Read

Stem Cells and Cellular Origins of Mammary Gland: Updates in Rationale, Controversies, and Cancer Relevance.

Stem Cells Int 2019 8;2019:4247168. Epub 2019 Jan 8.

Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jie-Fang Rd, Hangzhou, Zhejiang 310009, China.

Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two subtypes of mammary stem cells, including unipotent and multipotent, which specifically differentiate to luminal or basal cells. Read More

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http://dx.doi.org/10.1155/2019/4247168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341275PMC
January 2019

Stem/Progenitor Cells in Cardiopulmonary Health, Disease, and Treatment.

Stem Cells Int 2019 6;2019:9861403. Epub 2019 Jan 6.

Department of Physiology, Faculty of Medicine, Justus Liebig University, Giessen, Germany.

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https://www.hindawi.com/journals/sci/2019/9861403/
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http://dx.doi.org/10.1155/2019/9861403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339702PMC
January 2019
1 Read

Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells.

Stem Cells Int 2019 6;2019:6264931. Epub 2019 Jan 6.

Department of Medico-Surgical Sciences and Biotechnology, Sapienza University, Latina, Italy.

Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models. Several studies demonstrate that Notch3 expression renders cancer cells more resistant to carboplatin, contributing to chemoresistance and poor survival of OC-bearing patients. This suggests that Notch3 can represent both a biomarker and a target for therapeutic interventions in OC patients. Read More

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http://dx.doi.org/10.1155/2019/6264931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339748PMC
January 2019

Skeletal Muscle Resident Progenitor Cells Coexpress Mesenchymal and Myogenic Markers and Are Not Affected by Chronic Heart Failure-Induced Dysregulations.

Stem Cells Int 2019 3;2019:5690345. Epub 2019 Jan 3.

Institute of Molecular Biology and Genetics, National Almazov Medical Research Centre, Saint Petersburg, Russia.

Background And Purpose: In heart failure (HF), metabolic alterations induce skeletal muscle wasting and decrease of exercise capacity and quality of life. The activation of skeletal muscle regeneration potential is a prospective strategy to reduce muscle wasting; therefore, the aim of this project was to determine if functional properties of skeletal muscle mesenchymal progenitor cells (SM-MPC) were affected by HF-induced functional and metabolic dysregulations.

Methods: Gastrocnemius muscle biopsy samples were obtained from 3 healthy donors (HD) and 12 HF patients to purify mRNA for further analysis and to isolate SM-MPC. Read More

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https://www.hindawi.com/journals/sci/2019/5690345/
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http://dx.doi.org/10.1155/2019/5690345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335669PMC
January 2019
2 Reads

Pretreatment with G-CSF Could Enhance the Antifibrotic Effect of BM-MSCs on Pulmonary Fibrosis.

Stem Cells Int 2019 3;2019:1726743. Epub 2019 Jan 3.

Xiangya Nursing School, Central South University, Changsha, Hunan, China.

Granulocyte colony-stimulating factor (G-CSF) can promote the repair of a variety of damaged tissues, but the underlying mechanisms have not yet been fully elucidated. Bone marrow mesenchymal stem cells (BM-MSCs) play an important role in the repair of damaged tissue. The aim of this study was to explore whether pretreating BM-MSCs with G-CSF can promote their ability of homing to the lung after in vitro transplantation via upregulating the CXCR4 expression, potentially markedly increasing the antifibrotic effect of BM-MSCs. Read More

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http://dx.doi.org/10.1155/2019/1726743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335774PMC
January 2019
3 Reads

Fasudil Promotes BMSC Migration via Activating the MAPK Signaling Pathway and Application in a Model of Spinal Cord Injury.

Stem Cells Int 2018 30;2018:9793845. Epub 2018 Dec 30.

Laboratory of Osteology and Traumatology of Traditional Chinese Medicine, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Bone marrow-derived mesenchymal stem cells (BMSCs) are considered as transplants for the treatment of central nervous system (CNS) trauma, but the therapeutic effect is restricted by their finite mobility and homing capacity. Fasudil (FAS), a potent Rho kinase inhibitor, has been reported to alleviate nerve damage and induce the differentiation of BMSCs into neuron-like cells. However, the effect of FAS on the migration of BMSCs remains largely unknown. Read More

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http://dx.doi.org/10.1155/2018/9793845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332870PMC
December 2018

Accelerated Wound Healing by Fibroblasts Differentiated from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in a Pressure Ulcer Animal Model.

Stem Cells Int 2018 30;2018:4789568. Epub 2018 Dec 30.

Burn Institute, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea.

Fibroblasts synthesize and secrete dermal collagen, matrix proteins, growth factors, and cytokines. These characteristics of fibroblasts provide a potential way for fibroblast therapy to treat skin ulcers more effectively than conventional therapies such as cytokine therapy and negative pressure wound therapy. However, the obstacle to the commercialization of fibroblast therapy is the limited supply of cells with consistent quality. Read More

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http://dx.doi.org/10.1155/2018/4789568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332923PMC
December 2018

Murine Hematopoiesis Supported by Signaling from a Splenic Stromal Cell Line.

Stem Cells Int 2018 25;2018:9896142. Epub 2018 Dec 25.

Clem Jones Research Centre for Regenerative Medicine, Bond University, Gold Coast, Australia.

There are very few model systems which demonstrate hematopoiesis . Previously, we described unique splenic stromal cell lines which support the development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the differentiation of hematopoietic cells from progenitors . Read More

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http://dx.doi.org/10.1155/2018/9896142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323497PMC
December 2018
2 Reads

Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs).

Stem Cells Int 2018 25;2018:5965727. Epub 2018 Dec 25.

Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.

Safety issues associated with transcription factors or viruses may be avoided with the use of chemically induced pluripotent stem cells (CiPSCs), thus promoting their clinical application. Previously, we had successfully developed and standardized an induction method using small-molecule compound, with simple operation, uniform induction conditions, and clear constituents. In order to verify that the CiPSCs were indeed reprogrammed from mouse embryonic fibroblasts (MEFs), and further explore the underlying mechanisms, FSP-tdTomato mice were used to construct a fluorescent protein-tracking system of MEFs, for revealing the process of CiPSC reprogramming. Read More

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http://dx.doi.org/10.1155/2018/5965727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323470PMC
December 2018
1 Read

Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells.

Stem Cells Int 2018 24;2018:3753547. Epub 2018 Dec 24.

Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia.

Quiescence is the prevailing state of many cell types under homeostatic conditions. Yet, surprisingly, little is known about how quiescent cells respond to environmental challenges. The aim of the present study is to compare stress responses of cycling and quiescent mesenchymal stem cells (MSC). Read More

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http://dx.doi.org/10.1155/2018/3753547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323451PMC
December 2018
1 Read

Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats.

Stem Cells Int 2018 24;2018:3212643. Epub 2018 Dec 24.

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo 0608638, Japan.

Background: There are no approved drug treatments for liver fibrosis and nonalcoholic steatohepatitis (NASH), an advanced stage of fibrosis which has rapidly become a major cause of cirrhosis. Therefore, development of anti-inflammatory and antifibrotic therapies is desired. Mesenchymal stem cell- (MSC-) based therapy, which has been extensively investigated in regenerative medicine for various organs, can reportedly achieve therapeutic effect in NASH via paracrine action. Read More

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https://www.hindawi.com/journals/sci/2018/3212643/
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http://dx.doi.org/10.1155/2018/3212643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323530PMC
December 2018
4 Reads

Efficient Nonviral Transfection of Human Bone Marrow Mesenchymal Stromal Cells Shown Using Placental Growth Factor Overexpression.

Stem Cells Int 2018 24;2018:1310904. Epub 2018 Dec 24.

Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada.

Background: Human mesenchymal stromal/stem cells (hMSCs) hold great therapeutic potential due to their immunomodulatory and tissue regenerative properties. Enhancement of biological features of hMSCs by transfection has become a focus of investigation for cell- and gene-based therapies. However, many of the current transient transfection methods result in either low transfection efficiency or high cytotoxicity. Read More

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http://dx.doi.org/10.1155/2018/1310904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323439PMC
December 2018
1 Read

The Immunomodulatory Properties of Mesenchymal Stem Cells.

Stem Cells Int 2018 20;2018:9214831. Epub 2018 Dec 20.

Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

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http://dx.doi.org/10.1155/2018/9214831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317080PMC
December 2018
1 Read

Intervertebral Disc-Derived Stem/Progenitor Cells as a Promising Cell Source for Intervertebral Disc Regeneration.

Stem Cells Int 2018 18;2018:7412304. Epub 2018 Dec 18.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Intervertebral disc (IVD) degeneration is considered to be the primary reason for low back pain. Despite remarkable improvements in both pharmacological and surgical management of IVD degeneration (IVDD), therapeutic effects are still unsatisfactory. It is because of the fact that these therapies are mainly focused on alleviating the symptoms rather than treating the underlying cause or restoring the structure and biomechanical function of the IVD. Read More

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http://dx.doi.org/10.1155/2018/7412304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312624PMC
December 2018
1 Read
2.806 Impact Factor

Impact and Challenges of Mesenchymal Stem Cells in Medicine: An Overview of the Current Knowledge.

Stem Cells Int 2018 17;2018:5023925. Epub 2018 Dec 17.

Department of Cell Biology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1155/2018/5023925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312597PMC
December 2018
1 Read

Fibrin Glue Enhances Adipose-Derived Stromal Cell Cytokine Secretion and Survival Conferring Accelerated Diabetic Wound Healing.

Stem Cells Int 2018 19;2018:1353085. Epub 2018 Dec 19.

Department for Plastic Surgery and Hand Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany.

Introduction: Although chronic wounds are a major personal and economic burden, treatment options are still limited. Among those options, adipose-derived stromal cell- (ASC-) based therapies rank as a promising approach but are restricted by the harsh wound environment. Here we use a commercially available fibrin glue to provide a deliverable niche for ASCs in chronic wounds. Read More

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http://dx.doi.org/10.1155/2018/1353085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313983PMC
December 2018
1 Read

Adipose-Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress.

Stem Cells Int 2018 13;2018:9682856. Epub 2018 Dec 13.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. We evaluated the potential of adipose-derived mesenchymal stem cells (ASCs) as a therapeutic tool by studying the migration capacity of ASCs and their protective effect against RPE cell death under oxidative stress and . ASCs exhibited enhanced migration when exposed to conditioned medium of oxidative stressed RPE cells obtained by hydrogen peroxide. Read More

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https://www.hindawi.com/journals/sci/2018/9682856/
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http://dx.doi.org/10.1155/2018/9682856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311721PMC
December 2018
6 Reads

The Milk Thistle () Compound Silibinin Inhibits Cardiomyogenesis of Embryonic Stem Cells by Interfering with Angiotensin II Signaling.

Stem Cells Int 2018 13;2018:9215792. Epub 2018 Dec 13.

Department of Physiology, Faculty of Medicine, Justus Liebig University Gießen, Germany.

The milk thistle ( (L.) Gaertn.) compound silibinin may be an inhibitor of the angiotensin II type 1 (AT) receptor which is expressed in differentiating embryonic stem (ES) cells and is involved in the regulation of cardiomyogenesis. Read More

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https://www.hindawi.com/journals/sci/2018/9215792/
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http://dx.doi.org/10.1155/2018/9215792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311720PMC
December 2018
5 Reads

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer.

Stem Cells Int 2018 16;2018:8908751. Epub 2018 Dec 16.

Preclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.

Protein acetylation is one of the most important posttranslational modifications catalyzed by acetyltransferases and deacetylases, through the addition and removal of acetyl groups to lysine residues. Lysine acetylation can affect protein-nucleic acid or protein-protein interactions and protein localization, transport, stability, and activity. It regulates the function of a large variety of proteins, including histones, oncoproteins, tumor suppressors, and transcription factors, thus representing a crucial regulator of several biological processes with particular prominent roles in transcription and metabolism. Read More

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http://dx.doi.org/10.1155/2018/8908751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311713PMC
December 2018
1 Read

Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity.

Stem Cells Int 2018 16;2018:8693137. Epub 2018 Dec 16.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

A kidney has the ability to regenerate itself after a variety of renal injuries. Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases. The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles. Read More

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https://www.hindawi.com/journals/sci/2018/8693137/
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http://dx.doi.org/10.1155/2018/8693137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311717PMC
December 2018
4 Reads

Human Adipose Mesenchymal Stem Cells Show More Efficient Angiogenesis Promotion on Endothelial Colony-Forming Cells than Umbilical Cord and Endometrium.

Stem Cells Int 2018 13;2018:7537589. Epub 2018 Dec 13.

Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410078, China.

Angiogenesis is a complicated process in which perivascular cells play important roles. Multipotent mesenchymal stem/stromal cells (MSCs) from distinct tissues have been proved to be proangiogenic and share functional properties and gene expression profiles with perivascular cells. However, different tissues derived MSCs may exhibit different potential for clinical applications. Read More

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http://dx.doi.org/10.1155/2018/7537589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311802PMC
December 2018
1 Read

Environmental Influences on Stem Cell Behavior.

Stem Cells Int 2018 10;2018:7415460. Epub 2018 Dec 10.

AO Research Institute Davos, Davos, Switzerland.

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http://dx.doi.org/10.1155/2018/7415460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311709PMC
December 2018
1 Read

Comparison of the Proliferation and Differentiation Potential of Human Urine-, Placenta Decidua Basalis-, and Bone Marrow-Derived Stem Cells.

Stem Cells Int 2018 13;2018:7131532. Epub 2018 Dec 13.

Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610000, China.

Human multipotent stem cell-based therapies have shown remarkable potential in regenerative medicine and tissue engineering applications due to their abilities of self-renewal and differentiation into multiple adult cell types under appropriate conditions. Presently, human multipotent stem cells can be isolated from different sources, but variation among their basic biology can result in suboptimal selection of seed cells in preclinical and clinical research. Thus, the goal of this study was to compare the biological characteristics of multipotent stem cells isolated from human bone marrow, placental decidua basalis, and urine, respectively. Read More

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http://dx.doi.org/10.1155/2018/7131532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311712PMC
December 2018
1 Read

Single-Cell Gene Expression Analysis and Evaluation of the Therapeutic Function of Murine Adipose-Derived Stromal Cells (ASCs) from the Subcutaneous and Visceral Compartment.

Stem Cells Int 2018 11;2018:2183736. Epub 2018 Dec 11.

Klinikum rechts der Isar, Technische Universität München, Klinik für Plastische Chirurgie und Handchirurgie, München, Germany.

Introduction: Adipose-derived stromal cells (ASCs) are a promising resource for wound healing and tissue regeneration because of their multipotent properties and cytokine secretion. ASCs are typically isolated from the subcutaneous fat compartment, but can also be obtained from visceral adipose tissue. The data on their equivalence diverges. Read More

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http://dx.doi.org/10.1155/2018/2183736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311719PMC
December 2018
1 Read

Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate.

Stem Cells Int 2018 5;2018:9068203. Epub 2018 Dec 5.

Department of Bioengineering, Northeastern University, Boston, MA 02115, USA.

Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities. The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other environmental signals are beginning to be explored using biomaterial platforms. Biomaterials offer new opportunities to engineer the stem cell niches and 3D environments for exploring biophysical and immobilized signaling cues to further our control over stem cell fate. Read More

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http://dx.doi.org/10.1155/2018/9068203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304878PMC
December 2018
1 Read

The Potential of Menstrual Blood-Derived Mesenchymal Stem Cells for Cartilage Repair and Regeneration: Novel Aspects.

Stem Cells Int 2018 3;2018:5748126. Epub 2018 Dec 3.

Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius LT-08406, Lithuania.

Menstrual blood is a unique body fluid that contains mesenchymal stem cells (MSCs). These cells have attracted a great deal of attention due to their exceptional advantages including easy access and frequently accessible sample source and no need for complex ethical and surgical interventions, as compared to other tissues. Menstrual blood-derived MSCs possess all the major stem cell properties and even have a greater proliferation and differentiation potential as compared to bone marrow-derived MSCs, making them a perspective tool in a further clinical practice. Read More

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http://dx.doi.org/10.1155/2018/5748126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304826PMC
December 2018
2 Reads

Base Modifications: Regulation of Stem Cell Functions and Diseases.

Stem Cells Int 2018 9;2018:5402384. Epub 2018 Dec 9.

Zhejiang University, Zhejiang, China.

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http://dx.doi.org/10.1155/2018/5402384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304896PMC
December 2018
1 Read

The Impact of Epigenetic Signatures on Amniotic Fluid Stem Cell Fate.

Stem Cells Int 2018 25;2018:4274518. Epub 2018 Nov 25.

Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University, Chieti-Pescara, Italy.

Epigenetic modifications play a significant role in determining the fate of stem cells and in directing the differentiation into multiple lineages. Current evidence indicates that mechanisms involved in chromatin regulation are essential for maintaining stable cell identities. There is a tight correlation among DNA methylation, histone modifications, and small noncoding RNAs during the epigenetic control of stem cells' differentiation; however, to date, the precise mechanism is still not clear. Read More

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http://dx.doi.org/10.1155/2018/4274518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304862PMC
November 2018
1 Read

Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations.

Stem Cells Int 2018 6;2018:2472137. Epub 2018 Dec 6.

Institute for Cellular and Molecular Medicine, Department of Immunology and South African Medical Research Council Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

There is still much to learn about the cells used for cell- and gene-based therapies in the clinical setting. Stem cells are found in virtually all tissues in the human body. As a result, cells isolated from these tissues are a heterogeneous population consisting of various subpopulations including stem cells. Read More

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http://dx.doi.org/10.1155/2018/2472137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304857PMC
December 2018
1 Read

Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation.

Stem Cells Int 2018 2;2018:1848605. Epub 2018 Dec 2.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy NY 12180, USA.

Left-right symmetry breaking is a complex developmental process and an important part of embryonic axis development. As of yet, the biophysical mechanism behind LR asymmetry establishment remains elusive for the overall asymmetry of embryos as well as for the organ-specific asymmetry. Here, we demonstrate that inherent cellular chirality is observable in the cells of early embryonic stages using a 3D Matrigel bilayer system. Read More

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http://dx.doi.org/10.1155/2018/1848605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304839PMC
December 2018
1 Read

Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction.

Stem Cells Int 2018 25;2018:7045245. Epub 2018 Nov 25.

Department of Cardiology, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Chongqing 400042, China.

Myocardial infarction (MI) is one of the leading causes of death worldwide. Mesenchymal stem cell (MSC) transplantation is considered a promising approach and has made significant progress in preclinical studies and clinical trials for treating MI. However, hurdles including poor survival, retention, homing, and differentiation capacity largely limit the therapeutic effect of transplanted MSCs. Read More

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https://www.hindawi.com/journals/sci/2018/7045245/
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http://dx.doi.org/10.1155/2018/7045245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286742PMC
November 2018
2 Reads
2.806 Impact Factor

Guanylate-Binding Protein 1 Promotes Migration and Invasion of Human Periodontal Ligament Stem Cells.

Stem Cells Int 2018 28;2018:6082956. Epub 2018 Nov 28.

Department of Stomatology, Nuclear of Industry 416 Hospital, Chengdu, Sichuan 610051, China.

Mesenchymal stem/stromal cells (MSCs) are capable of migrating to sites of injury and inflammation in response to various cytokines to improve tissue repair. Previous studies have shown interferon-gamma (IFN-) promoted migration of the V54/2 cell line and dental pulp stem cells (DPSCs), but the underlying mechanisms remain largely unknown. In this study, we found IFN- induced migration and invasion of periodontal ligament stem cells (PDLSCs) in a dose-dependent manner . Read More

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https://www.hindawi.com/journals/sci/2018/6082956/
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http://dx.doi.org/10.1155/2018/6082956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304207PMC
November 2018
6 Reads

Novel Calcium Phosphate Cement with Metformin-Loaded Chitosan for Odontogenic Differentiation of Human Dental Pulp Cells.

Stem Cells Int 2018 27;2018:7173481. Epub 2018 Nov 27.

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, USA.

Metformin is an old and widely accepted first-line drug for treating type 2 diabetes. Our previous studies demonstrate that metformin can stimulate the osteo/odontogenic differentiation of human-induced pluripotent stem cell-derived mesenchymal stem cells and human dental pulp cells (DPCs). Due to the rapid dilution of metformin from the defect area, the aim of this study was to develop a drug delivery system with controlled release of metformin to promote cell viability and odontogenic differentiation of DPCs favoring dentin regeneration. Read More

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http://dx.doi.org/10.1155/2018/7173481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288571PMC
November 2018
1 Read

Human Pluripotent Stem Cell Culture: Current Status, Challenges, and Advancement.

Stem Cells Int 2018 22;2018:7396905. Epub 2018 Nov 22.

Institute for Stem Cell Biology and Regenerative Medicine (inStem), National Centre for Biological Sciences (NCBS), Bangalore, India.

Over the past two decades, human embryonic stem cells (hESCs) have gained attention due to their pluripotent and proliferative ability which enables production of almost all cell types in the human body and makes them an excellent tool to study human embryogenesis and disease, as well as for drug discovery and cell transplantation therapies. Discovery of human-induced pluripotent stem cells (hiPSCs) further expanded therapeutic applications of human pluripotent stem cells (PSCs). hPSCs provide a stable and unlimited original cell source for producing suitable cells and tissues for downstream applications. Read More

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http://dx.doi.org/10.1155/2018/7396905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282144PMC
November 2018
1 Read

Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects.

Stem Cells Int 2018 18;2018:9847015. Epub 2018 Nov 18.

B.D.S., M.D.S. (Prosthetic Dentistry), MRACDS (Pros), FRACDS, FCDHK (Pros), FHKAM (Dental Surgery), Clinical Associate Professor, Discipline of Prosthodontics, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong.

With the discovery of endothelial progenitor cells (EPCs) in the late 1990s, a paradigm shift in the concept of neoangiogenesis occurred. The identification of circulating EPCs in peripheral blood marked the beginning of a new era with enormous potential in the rapidly transforming regenerative field. Overwhelmed with the revelation, researchers across the globe focused on isolating, defining, and interpreting the role of EPCs in various physiological and pathological conditions. Read More

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http://dx.doi.org/10.1155/2018/9847015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276490PMC
November 2018
1 Read

New Strategies and In Vivo Monitoring Methods for Stem Cell-Based Anticancer Therapies.

Stem Cells Int 2018 15;2018:7315218. Epub 2018 Nov 15.

Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48823, USA.

Cancer is a devastating disease and the second cause of death in the developed world. Despite significant advances in recent years, such as the introduction of targeted therapies such as receptor tyrosine kinase inhibitors and immunotherapy, current approaches are insufficient to stop the advance of the disease and many cancer types remain largely intractable. In this review, we describe the latest and most revolutionary stem cell-based approaches for the treatment of cancer. Read More

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http://dx.doi.org/10.1155/2018/7315218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276456PMC
November 2018
3 Reads
2.806 Impact Factor

High Throughput Screening of Additives Using Factorial Design to Promote Survival of Stored Cultured Epithelial Sheets.

Stem Cells Int 2018 18;2018:6545876. Epub 2018 Nov 18.

Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.

There is a need to optimize storage conditions to preserve cell characteristics during transport of cultured cell sheets from specialized culture units to distant hospitals. In this study, we aimed to explore a method to identify additives that diminish the decrease in the viability of stored undifferentiated epidermal cells using multifactorial design and an automated screening procedure. The cultured cells were stored for 7-11 days at 12°C in media supplemented with various additives. Read More

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https://www.hindawi.com/journals/sci/2018/6545876/
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http://dx.doi.org/10.1155/2018/6545876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276401PMC
November 2018
6 Reads

Exogenous and Endogenous Stem Cells for Skeletal Regeneration.

Stem Cells Int 2018 18;2018:2574243. Epub 2018 Nov 18.

Institute of PLA Orthopaedics & Traumatology, Xi-jing Hospital, Fourth Military Medical University, Xi'an, China.

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https://www.hindawi.com/journals/sci/2018/2574243/
Publisher Site
http://dx.doi.org/10.1155/2018/2574243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276419PMC
November 2018
9 Reads