956 results match your criteria Stem cell reviews[Journal]


Cellular Based Strategies for Microvascular Engineering.

Stem Cell Rev 2019 Feb 10. Epub 2019 Feb 10.

Irvin S. Zubar Plastic Surgery Research Laboratory, Penn State College of Medicine, Hershey, PA 17033, USA.

Vascularization is a major hurdle in complex tissue and organ engineering. Tissues greater than 200 μm in diameter cannot rely on simple diffusion to obtain nutrients and remove waste. Therefore, an integrated vascular network is required for clinical translation of engineered tissues. Read More

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http://dx.doi.org/10.1007/s12015-019-09877-4DOI Listing
February 2019
5 Reads

Endothelial Progenitor Cells Modulate Inflammation-Associated Stroke Vasculome.

Stem Cell Rev 2019 Feb 9. Epub 2019 Feb 9.

Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.

Stroke remains a major unmet clinical need that warrants novel therapies. Following an ischemic insult, the cerebral vasculature secretes inflammatory molecules, creating the stroke vasculome profile. The present study evaluated the therapeutic effects of endothelial cells on the inflammation-associated stroke vasculome. Read More

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http://dx.doi.org/10.1007/s12015-019-9873-xDOI Listing
February 2019
3 Reads

The Ambivalent Role of lncRNA Xist in Carcinogenesis.

Stem Cell Rev 2019 Jan 26. Epub 2019 Jan 26.

Graduate Institute of Medical Informatics, Taipei Medical University, Taipei, Taiwan.

Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. Read More

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http://dx.doi.org/10.1007/s12015-019-9871-zDOI Listing
January 2019
1 Read

Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation.

Stem Cell Rev 2019 Jan 24. Epub 2019 Jan 24.

Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, 6th of October City, Giza, 12566, Egypt.

Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellitus (DM). Autologous MSCs are assumed to be favorable because patient-derived cells are readily available and do not entail sustained immunosuppressive therapy. Read More

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http://dx.doi.org/10.1007/s12015-018-9869-yDOI Listing
January 2019
1 Read

Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus.

Stem Cell Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.

Gestational diabetes mellitus (GDM) has been associated with an increased risk of maternal and neonatal morbidity. The Wharton's jelly (WJ) of the umbilical cord (UC) is a useful indicator of the deleterious effects of hyperglycemia on fetal tissues as it represents the fetus embryologically, physiologically and genetically. We studied WJ mesenchymal stem cells (hWJSCs) from UC from mothers without GDM (Normal; n = 3); insulin-controlled GDM mothers (GDMi; n = 3) and diet-controlled GDM mothers (GDMd; n = 3)]. Read More

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http://dx.doi.org/10.1007/s12015-019-9872-yDOI Listing
January 2019
2 Reads

Gelatin Based Polymer Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after Myocardial Infarction.

Stem Cell Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

Background: Acute myocardial infarction (AMI) and the ensuing ischemic heart disease are approaching an epidemic state. Limited stem cell retention following intracoronary administration has reduced the clinical efficacy of this novel therapy. Polymer based cell coating is biocompatible and has been shown to be safe. Read More

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http://link.springer.com/10.1007/s12015-018-9870-5
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http://dx.doi.org/10.1007/s12015-018-9870-5DOI Listing
January 2019
11 Reads

Biological Products: Cellular Therapy and FDA Approved Products.

Stem Cell Rev 2019 Jan 9. Epub 2019 Jan 9.

Department of Biology, School of Advanced Technologies in Medicine, Islamic Azad University Medical Branch of Tehran, Tehran, Iran.

The pace of advances in the world of science have created new opportunities and insights that give us new and more understanding of our nature and environment. Among the different fields of science, new medical sciences have drawn a great deal of attention among medical science researchers and the society. The hope for finding treatments for incurable diseases and further improvement of man's health is growing thanks to new medical technologies. Read More

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http://dx.doi.org/10.1007/s12015-018-9866-1DOI Listing
January 2019
2 Reads

What is in Store for 2019 in Stem Cell Reviews and Reports.

Stem Cell Rev 2019 Feb;15(1):1-2

University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1007/s12015-018-9868-zDOI Listing
February 2019
4 Reads

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling.

Stem Cell Rev 2018 Dec 17. Epub 2018 Dec 17.

Department of Obstetrics and Gynecology-Reproductive Medical Center of Shengjing Hospital Affiliated to China Medical University, Shenyang, China.

POI is characterized by "absent not abnormal" menstruation with hormonal disorders in woman younger than 40 years of age, and etiological and pathophysiological mechanisms underlying the POI development have not been clearly defined. Recently, due to advantages such as abundant sources and non-invasive methods of harvest, MenSCs have been emerging as a promising treatment strategy for the recovery of female reproductive damage. Here, we demonstrated that MenSCs graft in POI mice after CTX treatment could restore ovarian function by regulating normal follicle development and estrous cycle, reducing apoptosis in ovaries to maintain homeostasis of microenvironment and modulating serum sex hormones to a relatively normal status. Read More

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http://link.springer.com/10.1007/s12015-018-9867-0
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http://dx.doi.org/10.1007/s12015-018-9867-0DOI Listing
December 2018
9 Reads

Cell Therapy for Ischemic Stroke: How to Turn a Promising Preclinical Research into a Successful Clinical Story.

Stem Cell Rev 2018 Nov 15. Epub 2018 Nov 15.

INSERM U965, F-75475, Paris, France.

Stroke is a major public health issue with limited treatment. The pharmacologically or mechanically removing of the clot is accessible to less than 10% of the patients. Stem cell therapy is a promising alternative strategy since it increases the therapeutic time window but many issues remain unsolved. Read More

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http://link.springer.com/10.1007/s12015-018-9864-3
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http://dx.doi.org/10.1007/s12015-018-9864-3DOI Listing
November 2018
8 Reads

Integrative Analysis of CD133 mRNA in Human Cancers Based on Data Mining.

Stem Cell Rev 2019 Feb;15(1):23-34

Department of Cell Biology, College of Basic Medical Science, and Biological Anthropology Institute, Liaoning Medical University, Jinzhou, 121001, People's Republic of China.

CD133 is a wildly used cancer stem cell marker. The purpose of this study was to explore the significance of CD133 mRNA in human cancers mainly based on The Cancer Genome Atlas (TCGA) database. Bioinformatic analyses were done by using public repositories, including BioGPS, SAGE Genie tools, Oncomine analysis, Regulome Explorer, COSMIC analysis, and Kaplan-Meier Plotter. Read More

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http://dx.doi.org/10.1007/s12015-018-9865-2DOI Listing
February 2019
3 Reads

Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders.

Stem Cell Rev 2018 Nov 13. Epub 2018 Nov 13.

Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Boelelaan 1085, 1081HV, Amsterdam, The Netherlands.

Generation of proper controls is crucial in induced pluripotent stem cell (iPSC) studies. X-chromosomal disorders offer the potential to develop isogenic controls due to random X-chromosomal inactivation (XCI). However, the generation of such lines is currently hampered by skewed X-inactivation in fibroblast lines and X-chromosomal reactivation (XCR) after reprogramming. Read More

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http://link.springer.com/10.1007/s12015-018-9851-8
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http://dx.doi.org/10.1007/s12015-018-9851-8DOI Listing
November 2018
15 Reads

An Insight into DNA-free Reprogramming Approaches to Generate Integration-free Induced Pluripotent Stem Cells for Prospective Biomedical Applications.

Stem Cell Rev 2018 Nov 11. Epub 2018 Nov 11.

Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.

More than a decade ago, a pioneering study reported generation of induced Pluripotent Stem Cells (iPSCs) by ectopic expression of a cocktail of reprogramming factors in fibroblasts. This study has revolutionized stem cell research and has garnered immense interest from the scientific community globally. iPSCs hold tremendous potential for understanding human developmental biology, disease modeling, drug screening and discovery, and personalized cell-based therapeutic applications. Read More

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http://dx.doi.org/10.1007/s12015-018-9861-6DOI Listing
November 2018
2 Reads

Endothelial Progenitor Cells Biology in Diabetes Mellitus and Peripheral Arterial Disease and their Therapeutic Potential.

Stem Cell Rev 2018 Nov 9. Epub 2018 Nov 9.

Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Endothelial progenitors are a population of cells with the inherent capacity to differentiate into mature endothelial cells and proangiogenic paracrine action. These characteristics have led to extensive studies being performed and tested in the treatment of tissue ischemia. The natural course of diabetes mellitus (DM) results in multiple areas of vascular damage. Read More

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http://link.springer.com/10.1007/s12015-018-9863-4
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http://dx.doi.org/10.1007/s12015-018-9863-4DOI Listing
November 2018
9 Reads

Correction to: Bone Marrow Derived Pluripotent Cells are Pericytes which Contribute to Vascularization.

Stem Cell Rev 2019 Feb;15(1):155-156

Department of Orthopaedic Surgery, Mass General Hospital for Children and the Pediatric Orthopaedic Laboratory for Tissue Engineering, Harvard Medical School, Boston, MA, USA.

Please note the following errors in the original version. Read More

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http://link.springer.com/10.1007/s12015-018-9849-2
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http://dx.doi.org/10.1007/s12015-018-9849-2DOI Listing
February 2019
12 Reads

Use of a PTFE Micro-Bioreactor to Promote 3D Cell Rearrangement and Maintain High Plasticity in Epigenetically Erased Fibroblasts.

Stem Cell Rev 2019 Feb;15(1):82-92

Laboratory of Biomedical Embryology, Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, 20133, Milan, Italy.

Phenotype definition is driven by epigenetic mechanisms as well as directly influenced by the cell microenvironment and by biophysical signals deriving from the extracellular matrix. The possibility to interact with the epigenetic signature of an adult mature cell, reversing its differentiated state and inducing a short transient high plasticity window, was previously demonstrated. In parallel, in vitro studies have shown that 3D culture systems, mimicking cell native tissue, exert significant effects on cell behavior and functions. Read More

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http://link.springer.com/10.1007/s12015-018-9862-5
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http://dx.doi.org/10.1007/s12015-018-9862-5DOI Listing
February 2019
3 Reads

PD-L1 Expression on Lung Cancer Stem Cells in Metastatic Lymph Nodes Aspirates.

Stem Cell Rev 2018 Nov 5. Epub 2018 Nov 5.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1a Street, 02-097, Warsaw, Poland.

Objectives: An immunotherapy was found to be effective in achieving long-term survival in some lung cancer patients. It has emerged to searching for new immune biomarkers for select the best candidates to this therapy. It is suggested that cancer stem cells (CSCs) are responsible for tumor initiation, maintenance and its metastatic potential. Read More

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http://link.springer.com/10.1007/s12015-018-9860-7
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http://dx.doi.org/10.1007/s12015-018-9860-7DOI Listing
November 2018
21 Reads

Intrinsic Vascular Repair by Endothelial Progenitor Cells in Acute Coronary Syndromes: an Update Overview.

Stem Cell Rev 2019 Feb;15(1):35-47

Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.

Bone marrow-derived endothelial progenitor cells (EPCs) play a key role in the maintenance of endothelial homeostasis and endothelial repair at areas of vascular damage. The quantification of EPCs in peripheral blood by flow cytometry is a strategy to assess this reparative capacity. The number of circulating EPCs is inversely correlated with the number of cardiovascular risk factors and to the occurrence of cardiovascular events. Read More

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http://link.springer.com/10.1007/s12015-018-9857-2
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http://dx.doi.org/10.1007/s12015-018-9857-2DOI Listing
February 2019
9 Reads

Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models.

Stem Cell Rev 2019 Feb;15(1):13-22

Systems Biology Research Center, School of Bioscience, University of Skövde, SE-541 28, Skövde, Sweden.

The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients. Read More

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http://link.springer.com/10.1007/s12015-018-9858-1
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http://dx.doi.org/10.1007/s12015-018-9858-1DOI Listing
February 2019
26 Reads

Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury.

Stem Cell Rev 2019 Feb;15(1):59-66

Department of Dermatology, Kitasato University School of Medicine, Minami Ward, Sagamihara, 252-0374, Japan.

Our previous studies showed that nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells, which reside in the bulge area of the hair follicle, could restore injured nerve and spinal cord and differentiate into cardiac muscle cells. Here we transplanted mouse green fluorescent protein (GFP)-expressing HAP stem-cell colonies enclosed on polyvinylidene fluoride membranes (PFM) into the severed thoracic spinal cord of nude mice. After seven weeks of implantation, we found the differentiation of HAP stem cells into neurons and glial cells. Read More

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http://link.springer.com/10.1007/s12015-018-9856-3
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http://dx.doi.org/10.1007/s12015-018-9856-3DOI Listing
February 2019
12 Reads

Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells.

Stem Cell Rev 2018 Oct 18. Epub 2018 Oct 18.

Divisions of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Mesenchymal stem cells (MSCs) are currently being tested in several clinical trials. Mitochondria regulate many aspects of MSC function. Mitochondrial preproteins are rapidly translated and trafficked into the mitochondrion for assembly in their final destination, but whether coexisting cardiovascular risk factors modulate this process is unknown. Read More

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http://dx.doi.org/10.1007/s12015-018-9855-4DOI Listing
October 2018
2 Reads
2.770 Impact Factor

Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation.

Stem Cell Rev 2019 Feb;15(1):48-58

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, São Paulo, S.P., 05508-000, Brazil.

The bioactive peptide bradykinin obtained from cleavage of precursor kininogens activates the kinin-B2 receptor functioning in induction of inflammation and vasodilatation. In addition, bradykinin participates in kidney and cardiovascular development and neuronal and muscle differentiation. Here we show that kinin-B2 receptors are expressed throughout differentiation of murine C2C12 myoblasts into myotubes. Read More

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http://link.springer.com/10.1007/s12015-018-9850-9
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http://dx.doi.org/10.1007/s12015-018-9850-9DOI Listing
February 2019
11 Reads

Looking Back at the 2018 Year of Stem Cell Reviews and Reports.

Stem Cell Rev 2018 12;14(6):767-768

University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1007/s12015-018-9859-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223709PMC
December 2018
1 Read

MicroRNAs in the Migration of Mesenchymal Stem Cells.

Stem Cell Rev 2019 Feb;15(1):3-12

Department of Cell Biology, Jiangsu Key Laboratory of Stem Cell Research, Medical College of Soochow University, Suzhou, 215123, China.

Mesenchymal stem cells (MSCs) represent a promising source of cell-based therapies for treatment of a wide variety of injuries and diseases. Their tropism and migration to the damaged sites, which are elicited by cytokines secreted from tissues around pathology, are the prerequisite for tissue repair and regeneration. Better understanding of the elicited-migration of MSCs and discovering conditions that elevate their migration ability, will help to increase their homing to pathologies and improve therapeutic efficacy. Read More

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http://link.springer.com/10.1007/s12015-018-9852-7
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http://dx.doi.org/10.1007/s12015-018-9852-7DOI Listing
February 2019
6 Reads

Human Dental Pulp Stem Cells and Gingival Mesenchymal Stem Cells Display Action Potential Capacity In Vitro after Neuronogenic Differentiation.

Stem Cell Rev 2019 Feb;15(1):67-81

Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, 19 S. Manassas St. Lab Rm 225, Office 256, Memphis, TN, 38163, USA.

The potential of human mesenchymal stromal/stem cells (MSCs) including oral stem cells (OSCs) as a cell source to derive functional neurons has been inconclusive. Here we tested a number of human OSCs for their neurogenic potential compared to non-OSCs and employed various neurogenic induction methods. OSCs including dental pulp stem cells (DPSCs), gingiva-derived mesenchymal stem cells (GMSCs), stem cells from apical papilla and non-OSCs including bone marrow MSCs (BMMSCs), foreskin fibroblasts and dermal fibroblasts using non-neurosphere-mediated or neurosphere-mediated methods to guide them toward neuronal lineages. Read More

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http://link.springer.com/10.1007/s12015-018-9854-5
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http://dx.doi.org/10.1007/s12015-018-9854-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358481PMC
February 2019
12 Reads

Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner.

Stem Cell Rev 2019 Feb;15(1):139-154

Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.

Bioactive phospholipids, including sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and its derivative lysophosphatidic acid (LPA), have emerged as important mediators regulating the trafficking of normal and cancer cells. While the role of S1P in regulating migration of hematopoietic cells is well established, in this work we compared its biological effects to the effects of C1P, LPC, and LPA. We employed 10 human myeloid and lymphoid cell lines as well as blasts from AML patients. Read More

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http://link.springer.com/10.1007/s12015-018-9853-6
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http://dx.doi.org/10.1007/s12015-018-9853-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366663PMC
February 2019
3 Reads

Endothelial Colony-Forming Cells Do Not Participate to Fibrogenesis in a Bleomycin-Induced Pulmonary Fibrosis Model in Nude Mice.

Stem Cell Rev 2018 12;14(6):812-822

AP-HP, European Georges Pompidou Hospital, Hematology Department , Paris, France.

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease characterized by fibroblast proliferation, extracellular matrix deposition, destruction of pulmonary alveolar architecture and vascular remodeling. Apart pirfenidone or nintendanib that only slow down the fibrotic process, there is no curative treatment other than lung transplantation. Because cell therapy approaches have been proposed in IPF, we hypothesized that injection of endothelial colony-forming cells (ECFCs), the vasculogenic subtype of endothelial progenitor cells, could modulate fibrosis in a Nude mouse model of bleomycin induced-pulmonary fibrosis. Read More

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http://dx.doi.org/10.1007/s12015-018-9846-5DOI Listing
December 2018
6 Reads

Pluripotent Very Small Embryonic-Like Stem Cells in Adult Testes - An Alternate Premise to Explain Testicular Germ Cell Tumors.

Stem Cell Rev 2018 12;14(6):793-800

Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India.

Developmental exposure to endocrine disruptors has resulted in the increased incidence of infertility and testicular germ cell tumors (T2GCT) in young men residing in developed countries. Unlike T1GCT (infants and young children) and T3GCT (aged men), T2GCT arise from CIS/GCNIS that develops from pre-CIS. Pre-CIS represents undifferentiated, growth-arrested gonocytes that persist in fetal testes due to endocrine disruption. Read More

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http://dx.doi.org/10.1007/s12015-018-9848-3DOI Listing
December 2018
3 Reads

Static Magnetic Field (SMF) as a Regulator of Stem Cell Fate - New Perspectives in Regenerative Medicine Arising from an Underestimated Tool.

Stem Cell Rev 2018 12;14(6):785-792

Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392, Gießen, Germany.

Tissue engineering and stem cell-based therapies are one of the most rapidly developing fields in medical sciences. Therefore, much attention has been paid to the development of new drug-delivery systems characterized by low cytotoxicity, high efficiency and controlled release. One of the possible strategies to achieve these goals is the application of magnetic field and/or magnetic nanoparticles, which have been shown to exert a wide range of effects on cellular metabolism. Read More

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http://dx.doi.org/10.1007/s12015-018-9847-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223715PMC
December 2018
1 Read

Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice.

Stem Cell Rev 2019 Feb;15(1):93-111

Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.

A potential therapeutic strategy for diabetes is the transplantation of induced-insulin secreting cells. Based on the common embryonic origin of liver and pancreas, we studied the potential of adult human liver stem-like cells (HLSC) to generate in vitro insulin-producing 3D spheroid structures (HLSC-ILS). HLSC-ILS were generated by a one-step protocol based on charge dependent aggregation of HLSC induced by protamine. Read More

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http://link.springer.com/10.1007/s12015-018-9845-6
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http://dx.doi.org/10.1007/s12015-018-9845-6DOI Listing
February 2019
21 Reads

Aerosolised Mesenchymal Stem Cells Expressing Angiopoietin-1 Enhances Airway Repair.

Stem Cell Rev 2019 Feb;15(1):112-125

Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200, Bertam, Penang, Malaysia.

Background: The aim of this study was to investigate the effects of MSCs and MSC-expressing ANGPT1 (MSC-pANGPT1) treatment via aerosolisation in alleviating the asthma-related airway inflammation in the rabbit model.

Methods: Rabbits were sensitised and challenged with both intraperitoneal injection and inhalation of ovalbumin (Ova). MSCs and MSC-pANGPT1 cells were aerosolised into rabbit lungs using the MicroSprayer® Aerosolizer Model IA-1B 48 h after injury. Read More

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http://dx.doi.org/10.1007/s12015-018-9844-7DOI Listing
February 2019
2 Reads

The Impact of Morphine on the Characteristics and Function Properties of Human Mesenchymal Stem Cells.

Stem Cell Rev 2018 12;14(6):801-811

Department of Transplantation Immunology, Institute of Experimental Medicine of the Czech Academy of Sciences, 4, 142 20, Prague, Czech Republic.

Morphine is an analgesic drug therapeutically administered to relieve pain. However, this drug has numerous side effects, which include impaired healing and regeneration after injuries or tissue damages. It suggests negative effects of morphine on stem cells which are responsible for tissue regeneration. Read More

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http://dx.doi.org/10.1007/s12015-018-9843-8DOI Listing
December 2018
3 Reads

Expression of Cancer Stem Cell Biomarkers in Human Head and Neck Carcinomas: a Systematic Review.

Stem Cell Rev 2018 12;14(6):769-784

Department of Morphological Sciences, Health Sciences Center, Federal University of Santa Catarina, Trindade, Florianópolis, Santa Catarina, Brazil.

Malignant neoplasms may be composed of several cell groups, including cancer stem cells (CSC). These cells have been related with the capacity of metastasis, relapse and resistance to multiple drugs during chemotherapy. This study aims to identify CSC biomarkers and their expression pattern in human head and neck carcinomas. Read More

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http://link.springer.com/10.1007/s12015-018-9839-4
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http://dx.doi.org/10.1007/s12015-018-9839-4DOI Listing
December 2018
17 Reads

circRNA Expression Profiles in Human Bone Marrow Stem Cells Undergoing Osteoblast Differentiation.

Stem Cell Rev 2019 Feb;15(1):126-138

Department of Orthodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People's Republic of China.

Circular RNAs (circRNAs), which are produced by back-splicing events in genes, have emerged as factors in gene regulation and normal cellular homeostasis. They play an important role not only in normal development of tissues and organs, but also in disease pathogenesis and cell differentiation. However, the role of circRNAs in bone marrow stem cells (BMSCs) undergoing osteoblast differentiation remains largely unknown. Read More

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http://dx.doi.org/10.1007/s12015-018-9841-xDOI Listing
February 2019
12 Reads

Elevated Numbers of Circulating Very Small Embryonic-Like Stem Cells (VSELs) and Intermediate CD14++CD16+ Monocytes in IgA Nephropathy.

Stem Cell Rev 2018 10;14(5):686-693

Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, ul. Waszyngtona 13, 15-269, Bialystok, Poland.

IgA nephropathy (IgAN) is recognized as most frequent form of primary glomerulonephritis worldwide. IgAN is associated with renal degradation occurring due to irreversible pathological changes leading to glomerulosclerosis and interstitial fibrosis. It remains poorly understood whether and to what extent these changes are followed by the activation of regenerative mechanisms. Read More

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http://dx.doi.org/10.1007/s12015-018-9840-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132770PMC
October 2018
2 Reads

Analysis of the Paternally-Imprinted DLK1-MEG3 and IGF2-H19 Tandem Gene Loci in NT2 Embryonal Carcinoma Cells Identifies DLK1 as a Potential Therapeutic Target.

Stem Cell Rev 2018 12;14(6):823-836

Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY, 40202, USA.

The paternally-imprinted genes insulin-like growth factor 2 (IGF2), H19, delta-like homologue 1 (DLK1), and maternally-expressed gene 3 (MEG3) are expressed from the tandem gene loci IGF2-H19 and DLK1-MEG3, which play crucial roles in initiating embryogenesis and development. The erasure of imprinting (EOI) at differentially methylated regions (DMRs) which regulate the expression of these genes maintains the developmental quiescence of primordial germ cells (PGCs) migrating through the embryo proper during embryogenesis and prevents them from forming teratomas. To address the potential involvement of the IGF2-H19 and DLK1-MEG3 loci in the pathogenesis of embryonal carcinoma (EC), we investigated their genomic imprinting at DMRs in the human PGC-derived EC cell line NTera-2 (NT2). Read More

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http://dx.doi.org/10.1007/s12015-018-9838-5DOI Listing
December 2018
6 Reads

Will iPS Cells Regenerate or Just Provide Trophic Support to the Diseased Tissues?

Authors:
Deepa Bhartiya

Stem Cell Rev 2018 10;14(5):629-631

Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India.

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http://dx.doi.org/10.1007/s12015-018-9837-6DOI Listing
October 2018
1 Read

Incognito: Are Microchimeric Fetal Stem Cells that Cross Placental Barrier Real Emissaries of Peace?

Stem Cell Rev 2018 10;14(5):632-641

Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Gh. Marinescu street, 400337, Cluj-Napoca, Romania.

Chimerism occurs naturaly throughout gestation and can also occur as a consequence of transfusion and transplantation therapy. It consists of the acquisition and long-term persistence of a genetically distinct population of allogenic cells inside another organism. Previous reports have suggested that feto-maternal microchimerism could exert a beneficial effect on the treatment of hematological and solid tumors in patients treated by PBSCT. Read More

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http://dx.doi.org/10.1007/s12015-018-9834-9DOI Listing
October 2018
2 Reads

Cathelicidin Related Antimicrobial Peptide (CRAMP) Enhances Bone Marrow Cell Retention and Attenuates Cardiac Dysfunction in a Mouse Model of Myocardial Infarction.

Stem Cell Rev 2018 10;14(5):702-714

Gill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY, USA.

Background: Acute myocardial infarction (MI) and the ensuing ischemic heart disease are approaching epidemic state. Unfortunately, no definitive therapies are available and human regenerative therapies have conflicting results. Limited stem cell retention following intracoronary administration has reduced the clinical efficacy of this novel therapy. Read More

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http://dx.doi.org/10.1007/s12015-018-9833-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119631PMC
October 2018
3 Reads
2.770 Impact Factor

ZNF521 Has an Inhibitory Effect on the Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells.

Stem Cell Rev 2018 Dec;14(6):901-914

Laboratory of Molecular Haematopoiesis and Stem Cell Biology, University Magna Græcia, Catanzaro, Italy.

Mesenchymal stem cells (MSCs) are multipotent progenitors present in the bone marrow stroma and in subcutaneous abdominal fat, an abundant and easily accessible source of MSCs with the ability to differentiate along multiple lineage pathways. The stem cell-associated transcription co-factor Zinc Finger Protein 521 (ZNF521/zfp521) has been implicated in the control of the homeostasis of hematopoietic, neural and osteo-adipogenic progenitors. Here we document through the analysis of a panel of human adipose-derived stem cells (hADSCs), that ZNF521 strongly inhibits the generation of mature adipocytes. Read More

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http://dx.doi.org/10.1007/s12015-018-9830-0DOI Listing
December 2018
4 Reads

CD34+ Hematopoietic Stem Cell Count Is Predictive of Vascular Event Occurrence in Children with Sickle Cell Disease.

Stem Cell Rev 2018 Oct;14(5):694-701

Inserm UMR-S1140, Faculté de Pharmacie, Paris, France.

Background/objectives: Sickle cell disease (SCD) complications mostly result from vascular dysfunction, concerning systemic microvasculature and cerebral large vessels. The aim of this cohort study was to identify potential circulating biomarkers predictive for further vascular event occurrence in pediatric SCD.

Methods: We consecutively enrolled 108 children with SCD at steady state, aged 3-18 years old (median 9. Read More

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http://dx.doi.org/10.1007/s12015-018-9835-8DOI Listing
October 2018
4 Reads

Homing and Tracking of Iron Oxide Labelled Mesenchymal Stem Cells After Infusion in Traumatic Brain Injury Mice: a Longitudinal In Vivo MRI Study.

Stem Cell Rev 2018 Dec;14(6):888-900

Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, -54, Delhi, India.

Stem cells transplantation has emerged as a promising alternative therapeutic due to its potency at injury site. The need to monitor and non-invasively track the infused stem cells is a significant challenge in the development of regenerative medicine. Thus, in vivo tracking to monitor infused stem cells is especially vital. Read More

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http://dx.doi.org/10.1007/s12015-018-9828-7DOI Listing
December 2018
2 Reads
1 Citation
2.770 Impact Factor

A Circadian Rhythm in both Complement Cascade (ComC) Activation and Sphingosine-1-Phosphate (S1P) Levels in Human Peripheral Blood Supports a Role for the ComC-S1P Axis in Circadian Changes in the Number of Stem Cells Circulating in Peripheral Blood.

Stem Cell Rev 2018 Oct;14(5):677-685

Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland.

The number of hematopoietic stem/progenitor cells (HSPCs) circulating in peripheral blood (PB) is regulated by a circadian rhythm, and more HSPCs circulate in PB in the morning hours than at night. Different mechanisms have been proposed that might regulate this process, including changes in tonus of β-adrenergic innervation of bone marrow (BM) tissue. Our group reported that in mice circadian changes in the number of HSPCs circulating in PB correlates with diurnal activation of the complement cascade (ComC) and that the mice deficient in C5 component of ComC (C5-KO mice) do not show circadian changes in the number of circulating HSPCs in PB. Read More

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http://dx.doi.org/10.1007/s12015-018-9836-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132735PMC
October 2018
2 Reads

Functional Testing of Primitive Oocyte-like Cells Developed in Ovarian Surface Epithelium Cell Culture from Small VSEL-like Stem Cells: Can They Be Fertilized One Day?

Authors:
Irma Virant-Klun

Stem Cell Rev 2018 Oct;14(5):715-721

Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Slajmerjeva 3, 1000, Ljubljana, Slovenia.

Data from the literature show that there are different populations of stem cells present in human adult ovaries, including small stem cells resembling very small embryonic-like stem cells (VSELs). These small ovarian stem cells with diameters of up to 5 μm are present in the ovarian surface epithelium and can grow into bigger, primitive oocyte-like cells that express several markers of a germinal lineage and exhibit pluripotency but not the zona pellucida structure when cultured in vitro. In this report, we present the results of the functional testing of such primitive oocyte-like cells from one patient with premature ovarian failure after insemination with her partners' sperm. Read More

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http://dx.doi.org/10.1007/s12015-018-9832-yDOI Listing
October 2018
21 Reads

Role of Telomeric TRF2 in Orosphere Formation and CSC Phenotype Maintenance Through Efficient DNA Repair Pathway and its Correlation with Recurrence in OSCC.

Stem Cell Rev 2018 Dec;14(6):871-887

Molecular Stress and Stem Cell Biology Group, KIIT School of Biotechnology, Disease Biology Lab, KIIT University, Bhubaneswar, Odisha, 751024, India.

The major problem to effective treatment of oral cancer is the presence of therapy resistance. Presence of cancer stem cell in the bulk of tumor have been implicated in therapeutic resistance. In this study, we report a non-telomeric role of TRF2 in formation of oral cancer spheroids and CSC phenotype maintenance via an efficient DNA damage repair mechanism in the presence of chemotherapeutic insult. Read More

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http://link.springer.com/10.1007/s12015-018-9823-z
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http://dx.doi.org/10.1007/s12015-018-9823-zDOI Listing
December 2018
15 Reads

The Transplantation of hBM-MSCs Increases Bone Neo-Formation and Preserves Hearing Function in the Treatment of Temporal Bone Defects - on the Experience of Two Month Follow Up.

Stem Cell Rev 2018 12;14(6):860-870

Department of Oncology and Radiotherapy, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic.

Temporal bone reconstruction is a persisting problem following middle ear cholesteatoma surgery. Seeking to advance the clinical transfer of stem cell therapy we attempted the reconstruction of temporal bone using a composite bioartificial graft based on a hydroxyapatite bone scaffold combined with human bone marrow-derived mesenchymal stromal cells (hBM-MSCs). The aim of this study was to evaluate the effect of the combined biomaterial on the healing of postoperative temporal bone defects and the preservation of physiological hearing functions in a guinea pig model. Read More

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http://dx.doi.org/10.1007/s12015-018-9831-zDOI Listing
December 2018
14 Reads

Stem Cell Sources and Graft Material for Vascular Tissue Engineering.

Stem Cell Rev 2018 10;14(5):642-667

Department of Natural Sciences, Bonn-Rhine-Sieg University of Applied Sciences, Von-Liebig-Str. 20, 53359, Rheinbach, Germany.

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http://dx.doi.org/10.1007/s12015-018-9825-xDOI Listing
October 2018
2 Reads

Allogenic Myocytes and Mesenchymal Stem Cells Partially Improve Fatty Rotator Cuff Degeneration in a Rat Model.

Stem Cell Rev 2018 12;14(6):847-859

Department of Orthopaedics, Physical Medicine and Rehabilitation, Medical Center of the University of Munich (Ludwig-Maximilians-University), Marchioninistrasse 15, 81377, Munich, Germany.

Purpose: Rotator cuff (RC) tears result not only in functional impairment but also in RC muscle atrophy, muscle fattening and eventually to muscle fibrosis. We hypothesized that allogenic bone marrow derived mesenchymal stem cells (MSC) and myocytes can be utilized to improve the rotator cuff muscle fattening and increase the atrophied muscle mass in a rat model.

Methods: The right supraspinatus (SSP) tendons of 105 inbred rats were detached and muscle fattening was provoked over 4 weeks; the left side remained untouched (control group). Read More

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http://dx.doi.org/10.1007/s12015-018-9829-6DOI Listing
December 2018
3 Reads

Dental Pulp Tissue Engineering Using Mesenchymal Stem Cells: a Review with a Protocol.

Stem Cell Rev 2018 10;14(5):668-676

Department of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-Ku, Tokyo, 113-8549, Japan.

Mesenchymal stem cells (MSCs) are adult stem cells that can be isolated from human and animal sources such as rats. Recently, an in vivo protocol for pulp tissue engineering using implantation of bone marrow MSCs into rat pulpotomized molars was established by our research group. This coronal pulp regeneration model showed almost complete regeneration/healing with dentin bridge formation when the cavity was sealed with mineral trioxide aggregate (MTA) to create a biocompatible seal of the pulp. Read More

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http://link.springer.com/10.1007/s12015-018-9826-9
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http://dx.doi.org/10.1007/s12015-018-9826-9DOI Listing
October 2018
4 Reads