967 results match your criteria Stem cell reviews[Journal]


Cancer Stem Cells: Acquisition, Characteristics, Therapeutic Implications, Targeting Strategies and Future Prospects.

Stem Cell Rev 2019 Apr 16. Epub 2019 Apr 16.

Amity Institute of Biotechnology, Amity University, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai, Maharashtra, 410206, India.

Since last two decades, the major cancer research has focused on understanding the characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to their ability to initiate tumor growth, self-renewal property and multi-drug resistance. The discovery of the mechanism of acquisition of stem-like properties by carcinoma cells via epithelial-mesenchymal transition (EMT) has paved a way towards a deeper understanding of CSCs and presented a possible avenue for the development of therapeutic strategies. In spite of years of research, various challenges, such as identification of CSC subpopulation, lack of appropriate experimental models, targeting cancer cells and CSCs specifically without harming normal cells, are being faced while dealing with CSCs. Read More

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http://link.springer.com/10.1007/s12015-019-09887-2
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http://dx.doi.org/10.1007/s12015-019-09887-2DOI Listing
April 2019
1 Read

One-Year Observation of the SCID-Repopulating Cell Activities of Human Cord Blood-Derived CD34-Positive and -Negative Hematopoietic Stem Cells.

Stem Cell Rev 2019 Apr 13. Epub 2019 Apr 13.

Department of iPS Stem Cell Regenerative Medicine, Faculty of Medicine, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.

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http://dx.doi.org/10.1007/s12015-019-09884-5DOI Listing

Involvement of P2X7 Receptors in the Osteogenic Differentiation of Mesenchymal Stromal/Stem Cells Derived from Human Subcutaneous Adipose Tissue.

Stem Cell Rev 2019 Apr 6. Epub 2019 Apr 6.

Department of Medical, Oral and Biotechnology Sciences, Section of Pharmacology, University of Chieti-Pescara, Via dei Vestini 29, 66100, Chieti, Italy.

The ionotropic P2X7 receptor (P2X7R) is involved in bone homeostasis but its role in osteogenesis is controversial. Thus, we investigated the expression of P2X7R and the effects exerted by its modulation in mesenchymal stromal cells from human subcutaneous adipose tissue (S-ASCs), which have potential therapeutic application in bone regenerative medicine. We found that undifferentiated S-ASCs expressed P2X7R and its functional splice variants P2X7AR and P2X7BR. Read More

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http://link.springer.com/10.1007/s12015-019-09883-6
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http://dx.doi.org/10.1007/s12015-019-09883-6DOI Listing
April 2019
5 Reads

The Therapeutic Potential of Mesenchymal Stromal Cells in the Treatment of Chemotherapy-Induced Tissue Damage.

Stem Cell Rev 2019 Apr 2. Epub 2019 Apr 2.

Department of Molecular and Radiation Oncology, German Cancer Research Center (dkfz), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Chemotherapy constitutes one of the key treatment modalities for solid and hematological malignancies. Albeit being an effective treatment, chemotherapy application is often limited by its damage to healthy tissues, and curative treatment options for chemotherapy-related side effects are largely missing. As mesenchymal stromal cells (MSCs) are known to exhibit regenerative capacity mainly by supporting a beneficial microenvironment for tissue repair, MSC-based therapies may attenuate chemotherapy-induced tissue injuries. Read More

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http://dx.doi.org/10.1007/s12015-019-09886-3DOI Listing
April 2019
1 Read

Human Endothelial Colony Forming Cells Express Intracellular CD133 that Modulates their Vasculogenic Properties.

Stem Cell Rev 2019 Mar 16. Epub 2019 Mar 16.

Sorbonne Paris Cité, Université Paris Descartes, Paris, France.

Stem cells at the origin of endothelial progenitor cells and in particular endothelial colony forming cells (ECFCs) subtype have been largely supposed to be positive for the CD133 antigen, even though no clear correlation has been established between its expression and function in ECFCs. We postulated that CD133 in ECFCs might be expressed intracellularly, and could participate to vasculogenic properties. ECFCs extracted from cord blood were used either fresh (n = 4) or frozen (n = 4), at culture days <30, to investigate the intracellular presence of CD133 by flow cytometry and confocal analysis. Read More

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http://dx.doi.org/10.1007/s12015-019-09881-8DOI Listing

Evolving Definition of Adult Stem/Progenitor Cells.

Stem Cell Rev 2019 Mar 16. Epub 2019 Mar 16.

Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India.

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http://dx.doi.org/10.1007/s12015-019-09879-2DOI Listing
March 2019
2.768 Impact Factor

Molecular-Physiological Aspects of Regulatory Effect of Peptide Retinoprotectors.

Stem Cell Rev 2019 Mar 11. Epub 2019 Mar 11.

Saint Petersburg Institute of Bioregulation and Gerontlogy, Saint Petersburg, Russia.

Retinal diseases were always difficult problem for clinical ophthalmology. Modern methods of their treatment only decrease risk of complications, however in Russia was created better technology for this purpose: peptide bioregulators, which were made by sequential adding of amino acids one to another, binding with the promoter region of genes, and promoting retinoprotective effect by regulation of their expression, improving the state of the retina. Read More

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http://dx.doi.org/10.1007/s12015-019-09882-7DOI Listing

Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J.

Stem Cell Rev 2019 Mar 5. Epub 2019 Mar 5.

Department of Physiology, University of Louisville, Clinical and Translational Research Building, Room 322, 505 South Hancock Street, Louisville, KY, USA.

Despite considerable advances made in understanding of lung cancer biology, there has been meek improvement in lung cancer treatment outcome with 4% to 5% increase in 5-year survival rates in the last four decades. Underlying problem of lung cancer recurrence and poor prognosis is attributed to the presence of cancer stem cells (CSCs) which possess the potential to differentiate, proliferate and trigger chemo-resistance, tumor progression and metastasis, despite initial elimination of the tumor. To address specific targeting of CSCs, we investigated the effects of a small molecule Verrucarin J (VJ) on lung cancer cell lines A549 and H1793. Read More

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http://dx.doi.org/10.1007/s12015-019-09874-7DOI Listing
March 2019
3 Reads

Targeting T Cell Malignancies Using CD4CAR T-Cells and Implementing a Natural Safety Switch.

Stem Cell Rev 2019 Mar 2. Epub 2019 Mar 2.

Division of Blood and Bone Marrow Transplantation, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

T cell malignancies are aggressive diseases with no standard treatment available, often resulting in poor patient outcomes. Lately, the recent FDA approval of a CD19 CAR T cell therapy for B cell acute lymphoblastic leukemia has earned nationwide attention, leading to the possibility that success of CD19 CAR therapy can be extended to T cell malignancies. However, the impact of T cell depletion due to a shared antigen pool remains an issue to be resolved. Read More

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http://link.springer.com/10.1007/s12015-019-09876-5
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http://dx.doi.org/10.1007/s12015-019-09876-5DOI Listing
March 2019
12 Reads

Osteochondritis dissecans (OCD) in Horses - Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy.

Stem Cell Rev 2019 Feb 23. Epub 2019 Feb 23.

Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375, Wrocław, Poland.

Osteochondrosis (osteochondrosis dissecans; OCD) is a disease syndrome of growing cartilage related to different clinical entities such as epiphysitis, subchondral cysts and angular carpal deformities, which occurs in growing animals of all species, including horses. Nowadays, these disorders are affecting increasing numbers of young horses worldwide. As a complex multifactorial disease, OCD is initiated when failure in cartilage canals because of existing ischemia, chondrocyte biogenesis impairment as well as biochemical and genetic disruptions occur. Read More

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http://dx.doi.org/10.1007/s12015-019-09875-6DOI Listing
February 2019
1 Read

Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem Cells.

Stem Cell Rev 2019 Feb 21. Epub 2019 Feb 21.

Jiangxi Key Laboratory of Clinical and Translational Cancer Research, Department of Oncology, The Second Affiliated Hospital of Nanchang University, Min-De Road. 1, Nanchang City, 330006, Jiangxi Province, China.

Stem cell aging underlies aging-associated disorders, such as steeply increased incidences of tumors and impaired regeneration capacity upon stress. However, whether and how the intestinal stem cells age remains largely unknown. Here we show that intestinal stem cells derived from 24-month-old mice hardly form typical organoids with crypt-villus structures, but rather mainly form big, rounded cysts devoid of differentiated cell types, which mimics the culturing of heterozygous APC-deficient cells from the APC mouse line. Read More

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http://dx.doi.org/10.1007/s12015-019-09880-9DOI Listing
February 2019

Cellular Based Strategies for Microvascular Engineering.

Stem Cell Rev 2019 Apr;15(2):218-240

Irvin S. Zubar Plastic Surgery Research Laboratory, Penn State College of Medicine, Hershey, PA 17033, USA.

Vascularization is a major hurdle in complex tissue and organ engineering. Tissues greater than 200 μm in diameter cannot rely on simple diffusion to obtain nutrients and remove waste. Therefore, an integrated vascular network is required for clinical translation of engineered tissues. Read More

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http://dx.doi.org/10.1007/s12015-019-09877-4DOI Listing
April 2019
10 Reads

Endothelial Progenitor Cells Modulate Inflammation-Associated Stroke Vasculome.

Stem Cell Rev 2019 Apr;15(2):256-275

Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.

Stroke remains a major unmet clinical need that warrants novel therapies. Following an ischemic insult, the cerebral vasculature secretes inflammatory molecules, creating the stroke vasculome profile. The present study evaluated the therapeutic effects of endothelial cells on the inflammation-associated stroke vasculome. Read More

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http://dx.doi.org/10.1007/s12015-019-9873-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441406PMC
April 2019
8 Reads

The Ambivalent Role of lncRNA Xist in Carcinogenesis.

Stem Cell Rev 2019 Apr;15(2):314-323

Graduate Institute of Medical Informatics, Taipei Medical University, Taipei, Taiwan.

Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. Read More

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http://dx.doi.org/10.1007/s12015-019-9871-zDOI Listing
April 2019
1 Read

Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation.

Stem Cell Rev 2019 Apr;15(2):194-217

Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, 6th of October City, Giza, 12566, Egypt.

Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellitus (DM). Autologous MSCs are assumed to be favorable because patient-derived cells are readily available and do not entail sustained immunosuppressive therapy. Read More

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http://dx.doi.org/10.1007/s12015-018-9869-yDOI Listing
April 2019
1 Read

Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus.

Stem Cell Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.

Gestational diabetes mellitus (GDM) has been associated with an increased risk of maternal and neonatal morbidity. The Wharton's jelly (WJ) of the umbilical cord (UC) is a useful indicator of the deleterious effects of hyperglycemia on fetal tissues as it represents the fetus embryologically, physiologically and genetically. We studied WJ mesenchymal stem cells (hWJSCs) from UC from mothers without GDM (Normal; n = 3); insulin-controlled GDM mothers (GDMi; n = 3) and diet-controlled GDM mothers (GDMd; n = 3)]. Read More

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http://dx.doi.org/10.1007/s12015-019-9872-yDOI Listing
January 2019
2 Reads

Gelatin Based Polymer Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after Myocardial Infarction.

Stem Cell Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

Background: Acute myocardial infarction (AMI) and the ensuing ischemic heart disease are approaching an epidemic state. Limited stem cell retention following intracoronary administration has reduced the clinical efficacy of this novel therapy. Polymer based cell coating is biocompatible and has been shown to be safe. Read More

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http://link.springer.com/10.1007/s12015-018-9870-5
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http://dx.doi.org/10.1007/s12015-018-9870-5DOI Listing
January 2019
25 Reads

Biological Products: Cellular Therapy and FDA Approved Products.

Stem Cell Rev 2019 Apr;15(2):166-175

Department of Biology, School of Advanced Technologies in Medicine, Islamic Azad University Medical Branch of Tehran, Tehran, Iran.

The pace of advances in the world of science have created new opportunities and insights that give us new and more understanding of our nature and environment. Among the different fields of science, new medical sciences have drawn a great deal of attention among medical science researchers and the society. The hope for finding treatments for incurable diseases and further improvement of man's health is growing thanks to new medical technologies. Read More

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http://dx.doi.org/10.1007/s12015-018-9866-1DOI Listing
April 2019
2 Reads

What is in Store for 2019 in Stem Cell Reviews and Reports.

Stem Cell Rev 2019 Feb;15(1):1-2

University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1007/s12015-018-9868-zDOI Listing
February 2019
4 Reads

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling.

Stem Cell Rev 2019 Apr;15(2):241-255

Department of Obstetrics and Gynecology-Reproductive Medical Center of Shengjing Hospital Affiliated to China Medical University, Shenyang, China.

POI is characterized by "absent not abnormal" menstruation with hormonal disorders in woman younger than 40 years of age, and etiological and pathophysiological mechanisms underlying the POI development have not been clearly defined. Recently, due to advantages such as abundant sources and non-invasive methods of harvest, MenSCs have been emerging as a promising treatment strategy for the recovery of female reproductive damage. Here, we demonstrated that MenSCs graft in POI mice after CTX treatment could restore ovarian function by regulating normal follicle development and estrous cycle, reducing apoptosis in ovaries to maintain homeostasis of microenvironment and modulating serum sex hormones to a relatively normal status. Read More

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http://link.springer.com/10.1007/s12015-018-9867-0
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http://dx.doi.org/10.1007/s12015-018-9867-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441404PMC
April 2019
16 Reads

Cell Therapy for Ischemic Stroke: How to Turn a Promising Preclinical Research into a Successful Clinical Story.

Stem Cell Rev 2019 Apr;15(2):176-193

INSERM U965, F-75475, Paris, France.

Stroke is a major public health issue with limited treatment. The pharmacologically or mechanically removing of the clot is accessible to less than 10% of the patients. Stem cell therapy is a promising alternative strategy since it increases the therapeutic time window but many issues remain unsolved. Read More

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http://link.springer.com/10.1007/s12015-018-9864-3
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http://dx.doi.org/10.1007/s12015-018-9864-3DOI Listing
April 2019
11 Reads

Integrative Analysis of CD133 mRNA in Human Cancers Based on Data Mining.

Stem Cell Rev 2019 Feb;15(1):23-34

Department of Cell Biology, College of Basic Medical Science, and Biological Anthropology Institute, Liaoning Medical University, Jinzhou, 121001, People's Republic of China.

CD133 is a wildly used cancer stem cell marker. The purpose of this study was to explore the significance of CD133 mRNA in human cancers mainly based on The Cancer Genome Atlas (TCGA) database. Bioinformatic analyses were done by using public repositories, including BioGPS, SAGE Genie tools, Oncomine analysis, Regulome Explorer, COSMIC analysis, and Kaplan-Meier Plotter. Read More

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http://dx.doi.org/10.1007/s12015-018-9865-2DOI Listing
February 2019
4 Reads

Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders.

Stem Cell Rev 2019 Apr;15(2):276-285

Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Boelelaan 1085, 1081HV, Amsterdam, The Netherlands.

Generation of proper controls is crucial in induced pluripotent stem cell (iPSC) studies. X-chromosomal disorders offer the potential to develop isogenic controls due to random X-chromosomal inactivation (XCI). However, the generation of such lines is currently hampered by skewed X-inactivation in fibroblast lines and X-chromosomal reactivation (XCR) after reprogramming. Read More

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http://link.springer.com/10.1007/s12015-018-9851-8
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http://dx.doi.org/10.1007/s12015-018-9851-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441401PMC
April 2019
20 Reads

An Insight into DNA-free Reprogramming Approaches to Generate Integration-free Induced Pluripotent Stem Cells for Prospective Biomedical Applications.

Stem Cell Rev 2019 Apr;15(2):286-313

Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.

More than a decade ago, a pioneering study reported generation of induced Pluripotent Stem Cells (iPSCs) by ectopic expression of a cocktail of reprogramming factors in fibroblasts. This study has revolutionized stem cell research and has garnered immense interest from the scientific community globally. iPSCs hold tremendous potential for understanding human developmental biology, disease modeling, drug screening and discovery, and personalized cell-based therapeutic applications. Read More

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http://dx.doi.org/10.1007/s12015-018-9861-6DOI Listing
April 2019
2 Reads

Endothelial Progenitor Cells Biology in Diabetes Mellitus and Peripheral Arterial Disease and their Therapeutic Potential.

Stem Cell Rev 2019 Apr;15(2):157-165

Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Endothelial progenitors are a population of cells with the inherent capacity to differentiate into mature endothelial cells and proangiogenic paracrine action. These characteristics have led to extensive studies being performed and tested in the treatment of tissue ischemia. The natural course of diabetes mellitus (DM) results in multiple areas of vascular damage. Read More

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http://link.springer.com/10.1007/s12015-018-9863-4
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http://dx.doi.org/10.1007/s12015-018-9863-4DOI Listing
April 2019
15 Reads

Correction to: Bone Marrow Derived Pluripotent Cells are Pericytes which Contribute to Vascularization.

Stem Cell Rev 2019 Feb;15(1):155-156

Department of Orthopaedic Surgery, Mass General Hospital for Children and the Pediatric Orthopaedic Laboratory for Tissue Engineering, Harvard Medical School, Boston, MA, USA.

Please note the following errors in the original version. Read More

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http://link.springer.com/10.1007/s12015-018-9849-2
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http://dx.doi.org/10.1007/s12015-018-9849-2DOI Listing
February 2019
19 Reads

Use of a PTFE Micro-Bioreactor to Promote 3D Cell Rearrangement and Maintain High Plasticity in Epigenetically Erased Fibroblasts.

Stem Cell Rev 2019 Feb;15(1):82-92

Laboratory of Biomedical Embryology, Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, 20133, Milan, Italy.

Phenotype definition is driven by epigenetic mechanisms as well as directly influenced by the cell microenvironment and by biophysical signals deriving from the extracellular matrix. The possibility to interact with the epigenetic signature of an adult mature cell, reversing its differentiated state and inducing a short transient high plasticity window, was previously demonstrated. In parallel, in vitro studies have shown that 3D culture systems, mimicking cell native tissue, exert significant effects on cell behavior and functions. Read More

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http://link.springer.com/10.1007/s12015-018-9862-5
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http://dx.doi.org/10.1007/s12015-018-9862-5DOI Listing
February 2019
4 Reads

PD-L1 Expression on Lung Cancer Stem Cells in Metastatic Lymph Nodes Aspirates.

Stem Cell Rev 2019 Apr;15(2):324-330

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1a Street, 02-097, Warsaw, Poland.

Objectives: An immunotherapy was found to be effective in achieving long-term survival in some lung cancer patients. It has emerged to searching for new immune biomarkers for select the best candidates to this therapy. It is suggested that cancer stem cells (CSCs) are responsible for tumor initiation, maintenance and its metastatic potential. Read More

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http://link.springer.com/10.1007/s12015-018-9860-7
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http://dx.doi.org/10.1007/s12015-018-9860-7DOI Listing
April 2019
25 Reads

Intrinsic Vascular Repair by Endothelial Progenitor Cells in Acute Coronary Syndromes: an Update Overview.

Stem Cell Rev 2019 Feb;15(1):35-47

Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.

Bone marrow-derived endothelial progenitor cells (EPCs) play a key role in the maintenance of endothelial homeostasis and endothelial repair at areas of vascular damage. The quantification of EPCs in peripheral blood by flow cytometry is a strategy to assess this reparative capacity. The number of circulating EPCs is inversely correlated with the number of cardiovascular risk factors and to the occurrence of cardiovascular events. Read More

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http://link.springer.com/10.1007/s12015-018-9857-2
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http://dx.doi.org/10.1007/s12015-018-9857-2DOI Listing
February 2019
16 Reads

Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models.

Stem Cell Rev 2019 Feb;15(1):13-22

Systems Biology Research Center, School of Bioscience, University of Skövde, SE-541 28, Skövde, Sweden.

The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients. Read More

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http://link.springer.com/10.1007/s12015-018-9858-1
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http://dx.doi.org/10.1007/s12015-018-9858-1DOI Listing
February 2019
37 Reads

Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury.

Stem Cell Rev 2019 Feb;15(1):59-66

Department of Dermatology, Kitasato University School of Medicine, Minami Ward, Sagamihara, 252-0374, Japan.

Our previous studies showed that nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells, which reside in the bulge area of the hair follicle, could restore injured nerve and spinal cord and differentiate into cardiac muscle cells. Here we transplanted mouse green fluorescent protein (GFP)-expressing HAP stem-cell colonies enclosed on polyvinylidene fluoride membranes (PFM) into the severed thoracic spinal cord of nude mice. After seven weeks of implantation, we found the differentiation of HAP stem cells into neurons and glial cells. Read More

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http://link.springer.com/10.1007/s12015-018-9856-3
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http://dx.doi.org/10.1007/s12015-018-9856-3DOI Listing
February 2019
19 Reads

Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells.

Stem Cell Rev 2018 Oct 18. Epub 2018 Oct 18.

Divisions of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Mesenchymal stem cells (MSCs) are currently being tested in several clinical trials. Mitochondria regulate many aspects of MSC function. Mitochondrial preproteins are rapidly translated and trafficked into the mitochondrion for assembly in their final destination, but whether coexisting cardiovascular risk factors modulate this process is unknown. Read More

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http://dx.doi.org/10.1007/s12015-018-9855-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472993PMC
October 2018
2 Reads
2.770 Impact Factor

Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation.

Stem Cell Rev 2019 Feb;15(1):48-58

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, São Paulo, S.P., 05508-000, Brazil.

The bioactive peptide bradykinin obtained from cleavage of precursor kininogens activates the kinin-B2 receptor functioning in induction of inflammation and vasodilatation. In addition, bradykinin participates in kidney and cardiovascular development and neuronal and muscle differentiation. Here we show that kinin-B2 receptors are expressed throughout differentiation of murine C2C12 myoblasts into myotubes. Read More

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http://link.springer.com/10.1007/s12015-018-9850-9
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http://dx.doi.org/10.1007/s12015-018-9850-9DOI Listing
February 2019
18 Reads

Looking Back at the 2018 Year of Stem Cell Reviews and Reports.

Stem Cell Rev 2018 12;14(6):767-768

University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1007/s12015-018-9859-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223709PMC
December 2018
1 Read

MicroRNAs in the Migration of Mesenchymal Stem Cells.

Stem Cell Rev 2019 Feb;15(1):3-12

Department of Cell Biology, Jiangsu Key Laboratory of Stem Cell Research, Medical College of Soochow University, Suzhou, 215123, China.

Mesenchymal stem cells (MSCs) represent a promising source of cell-based therapies for treatment of a wide variety of injuries and diseases. Their tropism and migration to the damaged sites, which are elicited by cytokines secreted from tissues around pathology, are the prerequisite for tissue repair and regeneration. Better understanding of the elicited-migration of MSCs and discovering conditions that elevate their migration ability, will help to increase their homing to pathologies and improve therapeutic efficacy. Read More

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http://link.springer.com/10.1007/s12015-018-9852-7
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http://dx.doi.org/10.1007/s12015-018-9852-7DOI Listing
February 2019
8 Reads

Human Dental Pulp Stem Cells and Gingival Mesenchymal Stem Cells Display Action Potential Capacity In Vitro after Neuronogenic Differentiation.

Stem Cell Rev 2019 Feb;15(1):67-81

Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, 19 S. Manassas St. Lab Rm 225, Office 256, Memphis, TN, 38163, USA.

The potential of human mesenchymal stromal/stem cells (MSCs) including oral stem cells (OSCs) as a cell source to derive functional neurons has been inconclusive. Here we tested a number of human OSCs for their neurogenic potential compared to non-OSCs and employed various neurogenic induction methods. OSCs including dental pulp stem cells (DPSCs), gingiva-derived mesenchymal stem cells (GMSCs), stem cells from apical papilla and non-OSCs including bone marrow MSCs (BMMSCs), foreskin fibroblasts and dermal fibroblasts using non-neurosphere-mediated or neurosphere-mediated methods to guide them toward neuronal lineages. Read More

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http://link.springer.com/10.1007/s12015-018-9854-5
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http://dx.doi.org/10.1007/s12015-018-9854-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358481PMC
February 2019
16 Reads

Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner.

Stem Cell Rev 2019 Feb;15(1):139-154

Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.

Bioactive phospholipids, including sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and its derivative lysophosphatidic acid (LPA), have emerged as important mediators regulating the trafficking of normal and cancer cells. While the role of S1P in regulating migration of hematopoietic cells is well established, in this work we compared its biological effects to the effects of C1P, LPC, and LPA. We employed 10 human myeloid and lymphoid cell lines as well as blasts from AML patients. Read More

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http://link.springer.com/10.1007/s12015-018-9853-6
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http://dx.doi.org/10.1007/s12015-018-9853-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366663PMC
February 2019
6 Reads

Endothelial Colony-Forming Cells Do Not Participate to Fibrogenesis in a Bleomycin-Induced Pulmonary Fibrosis Model in Nude Mice.

Stem Cell Rev 2018 12;14(6):812-822

AP-HP, European Georges Pompidou Hospital, Hematology Department , Paris, France.

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease characterized by fibroblast proliferation, extracellular matrix deposition, destruction of pulmonary alveolar architecture and vascular remodeling. Apart pirfenidone or nintendanib that only slow down the fibrotic process, there is no curative treatment other than lung transplantation. Because cell therapy approaches have been proposed in IPF, we hypothesized that injection of endothelial colony-forming cells (ECFCs), the vasculogenic subtype of endothelial progenitor cells, could modulate fibrosis in a Nude mouse model of bleomycin induced-pulmonary fibrosis. Read More

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http://dx.doi.org/10.1007/s12015-018-9846-5DOI Listing
December 2018
7 Reads

Pluripotent Very Small Embryonic-Like Stem Cells in Adult Testes - An Alternate Premise to Explain Testicular Germ Cell Tumors.

Stem Cell Rev 2018 12;14(6):793-800

Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India.

Developmental exposure to endocrine disruptors has resulted in the increased incidence of infertility and testicular germ cell tumors (T2GCT) in young men residing in developed countries. Unlike T1GCT (infants and young children) and T3GCT (aged men), T2GCT arise from CIS/GCNIS that develops from pre-CIS. Pre-CIS represents undifferentiated, growth-arrested gonocytes that persist in fetal testes due to endocrine disruption. Read More

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http://dx.doi.org/10.1007/s12015-018-9848-3DOI Listing
December 2018
3 Reads

Static Magnetic Field (SMF) as a Regulator of Stem Cell Fate - New Perspectives in Regenerative Medicine Arising from an Underestimated Tool.

Stem Cell Rev 2018 12;14(6):785-792

Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392, Gießen, Germany.

Tissue engineering and stem cell-based therapies are one of the most rapidly developing fields in medical sciences. Therefore, much attention has been paid to the development of new drug-delivery systems characterized by low cytotoxicity, high efficiency and controlled release. One of the possible strategies to achieve these goals is the application of magnetic field and/or magnetic nanoparticles, which have been shown to exert a wide range of effects on cellular metabolism. Read More

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http://dx.doi.org/10.1007/s12015-018-9847-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223715PMC
December 2018
2 Reads

Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice.

Stem Cell Rev 2019 Feb;15(1):93-111

Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.

A potential therapeutic strategy for diabetes is the transplantation of induced-insulin secreting cells. Based on the common embryonic origin of liver and pancreas, we studied the potential of adult human liver stem-like cells (HLSC) to generate in vitro insulin-producing 3D spheroid structures (HLSC-ILS). HLSC-ILS were generated by a one-step protocol based on charge dependent aggregation of HLSC induced by protamine. Read More

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http://link.springer.com/10.1007/s12015-018-9845-6
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http://dx.doi.org/10.1007/s12015-018-9845-6DOI Listing
February 2019
30 Reads

Aerosolised Mesenchymal Stem Cells Expressing Angiopoietin-1 Enhances Airway Repair.

Stem Cell Rev 2019 Feb;15(1):112-125

Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200, Bertam, Penang, Malaysia.

Background: The aim of this study was to investigate the effects of MSCs and MSC-expressing ANGPT1 (MSC-pANGPT1) treatment via aerosolisation in alleviating the asthma-related airway inflammation in the rabbit model.

Methods: Rabbits were sensitised and challenged with both intraperitoneal injection and inhalation of ovalbumin (Ova). MSCs and MSC-pANGPT1 cells were aerosolised into rabbit lungs using the MicroSprayer® Aerosolizer Model IA-1B 48 h after injury. Read More

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http://dx.doi.org/10.1007/s12015-018-9844-7DOI Listing
February 2019
2 Reads

The Impact of Morphine on the Characteristics and Function Properties of Human Mesenchymal Stem Cells.

Stem Cell Rev 2018 12;14(6):801-811

Department of Transplantation Immunology, Institute of Experimental Medicine of the Czech Academy of Sciences, 4, 142 20, Prague, Czech Republic.

Morphine is an analgesic drug therapeutically administered to relieve pain. However, this drug has numerous side effects, which include impaired healing and regeneration after injuries or tissue damages. It suggests negative effects of morphine on stem cells which are responsible for tissue regeneration. Read More

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http://dx.doi.org/10.1007/s12015-018-9843-8DOI Listing
December 2018
5 Reads

Expression of Cancer Stem Cell Biomarkers in Human Head and Neck Carcinomas: a Systematic Review.

Stem Cell Rev 2018 12;14(6):769-784

Department of Morphological Sciences, Health Sciences Center, Federal University of Santa Catarina, Trindade, Florianópolis, Santa Catarina, Brazil.

Malignant neoplasms may be composed of several cell groups, including cancer stem cells (CSC). These cells have been related with the capacity of metastasis, relapse and resistance to multiple drugs during chemotherapy. This study aims to identify CSC biomarkers and their expression pattern in human head and neck carcinomas. Read More

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http://link.springer.com/10.1007/s12015-018-9839-4
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http://dx.doi.org/10.1007/s12015-018-9839-4DOI Listing
December 2018
21 Reads

circRNA Expression Profiles in Human Bone Marrow Stem Cells Undergoing Osteoblast Differentiation.

Stem Cell Rev 2019 Feb;15(1):126-138

Department of Orthodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People's Republic of China.

Circular RNAs (circRNAs), which are produced by back-splicing events in genes, have emerged as factors in gene regulation and normal cellular homeostasis. They play an important role not only in normal development of tissues and organs, but also in disease pathogenesis and cell differentiation. However, the role of circRNAs in bone marrow stem cells (BMSCs) undergoing osteoblast differentiation remains largely unknown. Read More

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http://dx.doi.org/10.1007/s12015-018-9841-xDOI Listing
February 2019
18 Reads

Elevated Numbers of Circulating Very Small Embryonic-Like Stem Cells (VSELs) and Intermediate CD14++CD16+ Monocytes in IgA Nephropathy.

Stem Cell Rev 2018 10;14(5):686-693

Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, ul. Waszyngtona 13, 15-269, Bialystok, Poland.

IgA nephropathy (IgAN) is recognized as most frequent form of primary glomerulonephritis worldwide. IgAN is associated with renal degradation occurring due to irreversible pathological changes leading to glomerulosclerosis and interstitial fibrosis. It remains poorly understood whether and to what extent these changes are followed by the activation of regenerative mechanisms. Read More

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http://dx.doi.org/10.1007/s12015-018-9840-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132770PMC
October 2018
2 Reads

Analysis of the Paternally-Imprinted DLK1-MEG3 and IGF2-H19 Tandem Gene Loci in NT2 Embryonal Carcinoma Cells Identifies DLK1 as a Potential Therapeutic Target.

Stem Cell Rev 2018 12;14(6):823-836

Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY, 40202, USA.

The paternally-imprinted genes insulin-like growth factor 2 (IGF2), H19, delta-like homologue 1 (DLK1), and maternally-expressed gene 3 (MEG3) are expressed from the tandem gene loci IGF2-H19 and DLK1-MEG3, which play crucial roles in initiating embryogenesis and development. The erasure of imprinting (EOI) at differentially methylated regions (DMRs) which regulate the expression of these genes maintains the developmental quiescence of primordial germ cells (PGCs) migrating through the embryo proper during embryogenesis and prevents them from forming teratomas. To address the potential involvement of the IGF2-H19 and DLK1-MEG3 loci in the pathogenesis of embryonal carcinoma (EC), we investigated their genomic imprinting at DMRs in the human PGC-derived EC cell line NTera-2 (NT2). Read More

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http://dx.doi.org/10.1007/s12015-018-9838-5DOI Listing
December 2018
7 Reads

Will iPS Cells Regenerate or Just Provide Trophic Support to the Diseased Tissues?

Authors:
Deepa Bhartiya

Stem Cell Rev 2018 10;14(5):629-631

Stem Cell Biology Department, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India.

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http://dx.doi.org/10.1007/s12015-018-9837-6DOI Listing
October 2018
1 Read

Incognito: Are Microchimeric Fetal Stem Cells that Cross Placental Barrier Real Emissaries of Peace?

Stem Cell Rev 2018 10;14(5):632-641

Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Gh. Marinescu street, 400337, Cluj-Napoca, Romania.

Chimerism occurs naturaly throughout gestation and can also occur as a consequence of transfusion and transplantation therapy. It consists of the acquisition and long-term persistence of a genetically distinct population of allogenic cells inside another organism. Previous reports have suggested that feto-maternal microchimerism could exert a beneficial effect on the treatment of hematological and solid tumors in patients treated by PBSCT. Read More

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http://dx.doi.org/10.1007/s12015-018-9834-9DOI Listing
October 2018
2 Reads