497,971 results match your criteria Stem cell research & therapy[Journal]


Pitfall in genetic screening in a pregnancy involving an allogeneic hematopoietic stem cell transplantation recipient.

Prenat Diagn 2018 Dec 6. Epub 2018 Dec 6.

Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.

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December 2018
11 Reads

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018
5 Reads

Pulmonary impairment following respiratory viral infections is associated with high mortality in allogeneic hematopoietic cell transplant recipients.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Introduction: Pulmonary impairment predicts increased mortality in many settings, and respiratory viral infection (RVI) causes considerable morbidity and mortality in allogeneic hematopoietic cell transplant recipients (allo-HCT). We hypothesized that pulmonary impairment following respiratory viral infection, defined as a decline of forced expiratory volume in 1 second values by ≥10%, may identify allo-HCT recipients at high risk for mortality.

Methods: We studied all allo-HCT recipients at our institution who had RVI with respiratory syncytial virus, parainfluenza virus, or influenza from 2004-2013 and had pre-RVI and post-RVI pulmonary function tests. Read More

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December 2018

Tools and strategies for constructing cell-free enzyme pathways.

Biotechnol Adv 2018 Dec 3. Epub 2018 Dec 3.

Department of Molecular Sciences, Macquarie University, Sydney, Australia; Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, Australia. Electronic address:

Single enzyme systems or engineered microbial hosts have been used for decades but the notion of assembling multiple enzymes into cell-free synthetic pathways is a relatively new development. The extensive possibilities that stem from this synthetic concept makes it a fast growing and potentially high impact field for biomanufacturing fine and platform chemicals, pharmaceuticals and biofuels. However, the translation of individual single enzymatic reactions into cell-free multi-enzyme pathways is not trivial. Read More

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December 2018
1 Read

Genetic inactivation of hypoxia inducible factor 1-alpha (HIF-1α) in adult hippocampal progenitors impairs neurogenesis and pattern discrimination learning.

Neurobiol Learn Mem 2018 Dec 3. Epub 2018 Dec 3.

Department of Neuroscience, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. Electronic address:

HIF-1α is a hypoxia-inducible protein that regulates many cellular processes, including neural stem cell maintenance. Previous work demonstrated constitutive stabilization of HIF-1α in neural stem cells (NSCs) of the adult mouse subventricular zone (SVZ) and hippocampal subgranular zone (SGZ). Genetic inactivation of NSC-encoded HIF-1α in the adult SVZ results in gradual loss of NSCs, but whether HIF-1α is required for the maintenance of SGZ hippocampal progenitors and adult hippocampal neurogenesis has not been determined. Read More

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December 2018

Cellular and Molecular Mechanisms of Regeneration in colonial and solitary Ascidians.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA USA.

Regenerative ability is highly variable among the metazoans. While many invertebrate organisms are capable of complete regeneration of entire bodies and organs, whole-organ regeneration is limited to very few species in the vertebrate lineages. Tunicates, which are invertebrate chordates and the closest extant relatives of the vertebrates, show robust regenerative ability. Read More

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December 2018
2 Reads

Locomotor central pattern generator excitability states and serotonin sensitivity after spontaneous recovery from a neonatal lumbar spinal cord injury.

Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Norwegian Center for Stem Cell Research, Oslo University Hospital, Norway. Electronic address:

The spinal locomotor central pattern generator (CPG) in neonatal mice exhibits diverse output patterns, ranging from sub-rhythmic to multi-rhythmic to fictive locomotion, depending on its general level of excitation and neuromodulatory status (Sharples and Whelan, 2017). We have recently reported that the locomotor CPG in neonatal mice rapidly recovers the ability to produce neurochemically induced fictive locomotion following an upper lumbar spinal cord compression injury (Züchner et al., 2018). Read More

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December 2018
1 Read

Physiological Models of Human Neuronal Development and Disease.

Neuron 2018 Dec;100(5):1025-1027

Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Human neural network development occurs at stages inaccessible to longitudinal monitoring. By transplanting human neurons to the adult mouse brain, recent studies explore human neural circuit formation in realistic cellular and physiological environments, establishing new models for human neurodevelopmental disorders. Read More

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December 2018

Structure and biomechanics of the antennal grooming mechanism in the southern green stink bug Nezara viridula.

J Insect Physiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Functional Morphology and Biomechanics, Kiel University, Germany.

Insects devote a high amount of time to self-groom to remove foreign material, especially from their sensory appendages. Using various microscopy techniques and behavioural experiments on intact and ablated insects, the present study investigates the antennal grooming of the green stinkbug Nezara viridula, which represents a serious pest of different crops in most areas of the world. The antennal grooming behaviour encompass an action of scraping involving the tibial comb complex (tibial comb + fossula) of both forelegs, generally followed by the tibial comb complex grooming of one leg using the tarsal hairy pad of the opposite leg (rubbing). Read More

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December 2018

A simple DNAzyme-based fluorescent assay for Klebsiella pneumoniae.

Chembiochem 2018 Dec 6. Epub 2018 Dec 6.

University of California Irvine, Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Edwards Lifesciences Center for Advanced Cardiovascular Technology, Biomedical Engineering, 92697, Irvine, UNITED STATES.

Pathogenic bacteria pose a serious public health threat. Rapid and cost effective detection of such bacteria remains a major challenge. Here, we present a DNAzyme-based fluorescent paper sensor for Klebsiella pneumoniae. Read More

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December 2018
2 Reads

Polyphenol enriched ethanolic extract of Cajanus scarabaeoides (L.) Thouars exerts potential antifilarial activity by inducing oxidative stress and programmed cell death.

PLoS One 2018 6;13(12):e0208201. Epub 2018 Dec 6.

Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan, India.

Development of antifilarial drug from the natural sources is considered as one of the most efficacious, safe, and affordable approaches. In this study, we report the antifilarial activity of a leguminous plant Cajanus scarabaeoides (L.) Thouars. Read More

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December 2018
2 Reads

Human bone marrow contains high levels of extracellular vesicles with a tissue-specific subtype distribution.

PLoS One 2018 6;13(12):e0207950. Epub 2018 Dec 6.

Gynecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Innsbruck, Austria.

Introduction: Extracellular vesicles (EV) are shed from a broad variety of cells and play an important role in activation of coagulation, cell to cell interaction and transport of membrane components. They are usually measured as circulating EV in peripheral blood (PB) and other body fluids. However, little is known about the distribution, presence and impact of EV and their subpopulations in bone marrow (BM). Read More

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December 2018

Identification of uterine telocytes and their architecture in leiomyoma.

Folia Med Cracov 2018 ;58(3):89-102

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More

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January 2018
1 Read

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA-stem.

J Clin Invest 2018 Dec 6. Epub 2018 Dec 6.

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralising antibody responses against highly diverse epitopes within the "head" of the viral hemagglutinin (HA) protein. There is increasing interest on redirecting immunity towards the more conserved HA-stem or stalk as a means to broaden protective antibody responses. Here we examined HA-stem-specific B cell and T-follicular helper (Tfh) cell responses in the context of influenza infection and immunisation in mouse and monkey models. Read More

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December 2018

Unexplained cytopenias in an adolescent? You GATA think about it.

J Assoc Genet Technol 2018 ;44(4):135-136

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Objectives: The GATA family of DNA binding proteins consists of six different transcription factors (GATA1-6), each with a diverse biologic function. The transcription factors GATA1-3 function primarily to orchestrate hematopoiesis; however, they have roles in non-hematopoietic cells as well. Much of our current knowledge of the GATA transcription factors has come through observation of disease states with known GATA mutations. Read More

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January 2018

Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite.

FASEB J 2018 Dec 6:fj201802075R. Epub 2018 Dec 6.

Key Laboratory of Microgravity, Center of Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China.

Bone marrow-derived mesenchymal stem cells (BMSCs) are able to differentiate into functional hepatocytelike cells, which are expected to serve as a potential cell source in regenerative medicine, tissue engineering, and clinical treatment of liver injury. Little is known about whether and how space microgravity is able to direct the hepatogenic differentiation of BMSCs in the actual space microenvironment. In this study, we examined the effects of space microgravity on BMSC hepatogenic differentiation on board the SJ-10 Recoverable Scientific Satellite. Read More

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December 2018
1 Read
5.043 Impact Factor

Trained murine mesenchymal stem cells have anti-inflammatory effect on macrophages, but defective regulation on T-cell proliferation.

FASEB J 2018 Dec 6:fj201801845R. Epub 2018 Dec 6.

Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California, USA; and.

Mesenchymal stem cell (MSC)-mediated immunomodulation affects both innate and adaptive immune systems. These responses to environmental cues, such as pathogen-associated molecular patterns, damage-associated molecular patterns, or proinflammatory cytokines, are crucial for resolution of inflammation, as well as successful tissue healing and regeneration. We observed that intermittent, repeated exposure of MSCs to LPS induced stronger NF-κB activation than singular stimulation. Read More

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December 2018

On the Electrochemical Degradation of Pt-Ni Nanocatalysts: An Identical Location Aberration-Corrected STEM Study.

Nano Lett 2018 Dec 6. Epub 2018 Dec 6.

The evolution of PtNi nanopartiles supported on amorphous carbon is investigated before and after electrochemical potential cycling (0.6-1.1V), using aberration-corrected STEM and EDS. Read More

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December 2018
2 Reads

Improving the Electrochemical Properties of the Manganese-Based P3 Phase by Multiphasic Intergrowth.

Inorg Chem 2018 Dec 6. Epub 2018 Dec 6.

State Key Laboratory of Powder Metallurgy , Central South University , Changsha , Hunan 410083 , P. R. China.

Layered transition-metal oxides are one kind of the most promising cathode materials for sodium-ion batteries. In this study, we propose a strategy to enhance the electrochemical properties of P3-type manganese-based layered oxide cathode by introducing a small amount of layered P2 and Li-O'3 phases. Powder X-ray diffraction (PXRD) structural refinement and aberration-corrected scanning transmission electron microscopy (STEM) are performed to confirm the microstructures of different samples. Read More

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December 2018

Direct Imaging of Photo-Switching Molecular Conformations Using Individual Metal Atom Markers.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

Photo-switching behavior of individual organic molecules was imaged by annular dark-field scanning transmission electron microscopy (ADF-STEM) using a highly electron beam transparent graphene support. Photo-switching azobenzene derivatives with ligands at each ends containing single transition metal atoms (Pt) were designed (Pt-complex), and the distance between the strong ADF-STEM contrast from the two Pt atoms in each Pt-complex is used to track molecular length changes. UV irradiation was used to induce photo-switching of the Pt complex on graphene, and we show that the measured Pt-Pt distances within isolated molecules decreases from ~2. Read More

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December 2018

Human Embryonic Stem Cells: Distinct Molecular Personalities and Applications in Regenerative Medicine.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Seattle Science Foundation, Seattle, WA, USA.

The field of stem cell biology is exciting because it provides researchers and clinicians with seemingly unlimited applications for treating many human diseases. Stem cells are a renewable source of pluripotent cells that can differentiate into nearly all human cell types. In this article we focus particularly on human embryonic stem (hES) cells, derived from the inner cell mass of the blastocyst and cultured for expansion while remaining undifferentiated, to explore their unique molecular personalities and clinical applications. Read More

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December 2018
1 Read

Extreme cold consistently reduces seedling growth but has species-specific effects on browse tolerance in summer.

Am J Bot 2018 Dec 6. Epub 2018 Dec 6.

Department of Integrative Biology, University of Wisconsin-Madison, 250 N. Mills Street, Madison, WI, 53706, USA.

Premise Of The Study: Extreme weather events can injure plants, causing decreased survival. However, we may underestimate the ecological importance of extreme events if they have strong sublethal effects that manifest after several months. We tested the hypothesis that late-winter extreme-cold events decrease the ability of woody plants to grow and tolerate stem removal in summer. Read More

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December 2018

Methane production and emissions in trees and forests.

New Phytol 2018 Dec 6. Epub 2018 Dec 6.

Smithsonian Environmental Research Center, 647 Contees Wharf Road, Edgewater, MD, 21037.

Forest ecosystem methane (CH ) research has focused on soils, but trees are also important sources and sinks in forest CH budgets. Living and dead trees transport and emit CH produced in soils; living trees and deadwood emit CH produced inside trees by microorganisms; and trees produce CH through an abiotic photochemical process. Here, we review the state of the science on the production, consumption, transport, and emission of CH by living and dead trees, and the spatial and temporal dynamics of these processes across hydrologic gradients inclusive of wetland and upland ecosystems. Read More

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December 2018
2 Reads

Differences in peripheral and tissue immune cell populations following hematopoietic stem cell transplantation in Crohn's disease patients.

J Crohns Colitis 2018 Dec 6. Epub 2018 Dec 6.

Department of Gastroenterology, IDIBAPS, Hospital Clínic, Barcelona, Spain.

Background And Aims: Recent studies show the efficacy of autologous hematopoietic stem cell transplantation (HSCT) in severely refractory Crohn's disease (CD) patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available.

Methods: We followed a group of CD patients (n=18) receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. Read More

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December 2018
2 Reads

CuO-Coated and Cu-doped Co-modified P2-type Na[NiMn]O for sodium-ion batteries.

Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.

College of Materials Science and Opto-electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.

Layered P2-type CuO-coated Na2/3[Ni1/3Mn2/3]O2 (NNMO@CuO) with excellent rate capability and cycling performance was investigated as a sodium-ion battery cathode material for the first time. The NNMO@CuO cathode material combines the advantages of CuO coating and Cu2+ doping. Transmission electron microscopy (TEM) images, TEM elemental line scan analysis and ex situ scanning electron microscopy (SEM) images show that CuO has been successfully coated on the particle surface uniformly, and that this CuO layer effectively suppresses the exfoliation of the metal oxide layers and unfavorable side reactions. Read More

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December 2018

Building a career planning course for STEM PhDs.

Nat Biotechnol 2018 Dec;36(12):1217-1219

Career and Postdoctoral Services Office, The Scripps Research Institute, La Jolla, California, USA.

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December 2018

Paclitaxel, 5-fluorouracil, and leucovorin combination chemotherapy as first-line treatment in patients with advanced gastric cancer.

Anticancer Drugs 2018 Dec 4. Epub 2018 Dec 4.

Medical Oncology, Fujian Medical University Union Hospital.

The aim of this retrospective analysis was to evaluate the efficacy and toxicity of combination chemotherapy with paclitaxel, 5-fluorouracil, and leucovorin (TFL) as first-line treatment in patients with advanced gastric cancer (AGC). One hundred and thirteen patients were enrolled in the study who were confirmed to have AGC by histopathology. These patients were treated with TFL: paclitaxel at a dose of 135 mg/m as a 3-h intravenous infusion on day 1, LV 400 mg/m as an intravenous infusion over 2 h on day 1, followed by 5-fluorouracil 2400 mg/m as an infusion over a 46-h period on 3 consecutive days. Read More

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December 2018

Control of neural crest multipotency by Wnt signaling and the Lin28/ axis.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Molecular Biology and Genetics,, Cornell University, Ithaca, United States.

A crucial step in cell differentiation is the silencing of developmental programs underlying multipotency. While much is known about how lineage-specific genes are activated to generate distinct cell types, the mechanisms driving suppression of stemness are far less understood. To address this, we examined the regulation of the transcriptional network that maintains progenitor identity in avian neural crest cells. Read More

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December 2018
1 Read

Stem cells repurpose proliferation to contain a breach in their niche barrier.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Robin Neustein Laboratory of Mammalian Development and Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt barrier function, adjacent stem cells dramatically change their transcriptome independent of bacterial invasion and become capable of directly signaling to and recruiting immune cells. Read More

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December 2018

Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy using Plakophilin-2 Mutant Myocytes.

Tissue Eng Part A 2018 Dec 6. Epub 2018 Dec 6.

Johns Hopkins University School of Medicine, Biomedical Engineering, Baltimore, Maryland, United States ;

Arrhythmogenic cardiomyopathy (AC), a cause of sudden cardiac death among young and otherwise healthy individuals, is a heritable disease that can be modeled in vitro using patient-specific cardiac myocytes (CMs) from induced pluripotent stem cells. An understanding of underlying disease mechanisms, particularly in the early concealed stages, could lead to new diagnosis and treatment strategies. However, multicellular syncytial models are needed to understand how genetically-encoded mutations of the desmosomes that interconnect cells lead to aberrant electrical conduction and arrhythmias. Read More

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December 2018

Effects of High- and Low-LET Radiation on Human Hematopoietic System Reconstituted in Immunodeficient Mice.

Radiat Res 2018 Dec 6. Epub 2018 Dec 6.

a   Columbia University Medical Center, New York, New York.

Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that may be induced by high-energy galactic cosmic rays encountered on interplanetary space missions. To collect data on the effects of space radiation on the human hematopoietic system in vivo, we used a humanized mouse model. Read More

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December 2018
1 Read

RNA regulons are essential in intestinal homeostasis.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pediatrics, GI Division, Children's Hospital of Philadelphia, United States.

Intestinal epithelial cells are among the most rapidly proliferating cell types in the human body. There are several different sub-types of epithelial cells, each with unique functional roles in responding to the ever-changing environment. The epithelium's ability for rapid and customized responses to environmental changes requires multi-tiered levels of gene regulation. Read More

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December 2018

Knitted silk mesh-like scaffold incorporated with sponge-like regenerated silk fibroin/collagen I and seeded with mesenchymal stem cells for repairing Achilles tendon in rabbits.

Acta Bioeng Biomech 2018 ;20(4):77-87

Institute of Bioengineering, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang Province, China.

A scaffold knit with natural sericin-free silk fibroin fiber possesses desirable mechanical properties, biocompatibility, ease of fabrication, and slow degradability. However, regenerated silk fibroin degrades faster than natural silk. In this study, natural silk fibroin fiber mesh-like scaffolds were prepared by a weft-knitting method and the pores were filled with sponge-like regenerated silk fibroin-collagen I. Read More

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January 2018
1 Read

Role of FGF signalling in neural crest cell migration during early chick embryo development.

Zygote 2018 Dec 6:1-8. Epub 2018 Dec 6.

1Department of Histology and Embryology, International Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College,Jinan University,Guangzhou 510632,China.

SummaryFibroblast growth factor (FGF) signalling acts as one of modulators that control neural crest cell (NCC) migration, but how this is achieved is still unclear. In this study, we investigated the effects of FGF signalling on NCC migration by blocking this process. Constructs that were capable of inducing Sprouty2 (Spry2) or dominant-negative FGFR1 (Dn-FGFR1) expression were transfected into the cells making up the neural tubes. Read More

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December 2018
2 Reads

Fingerprint pattern of bone mineralisation on cemented and uncemented femoral stems: analysis by [18F]-fluoride-PET in a randomised clinical trial.

Hip Int 2018 Dec 6:1120700018815404. Epub 2018 Dec 6.

4 Depaetment of Orthopaedics, Uppsala University Hospital, Sweden.

Purpose:: We present a randomised clinical study using 18F-fluoride positron emission tomography/computed tomography (F-PET/CT) to analyse the osteoblastic part of bone metabolism (new bone mineralisation) in periprosthetic bone adjacent to femoral stems following total hip arthoplasty (THA) surgery. Patients with hip osteoarthritis were randomly assigned to THA surgery with cemented or uncemented femoral components.

Patients And Methods:: THA was performed on 26 patients (26 cases) with hip osteoarthritis. Read More

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December 2018
1 Read

Revealing Pathways of Cardiac Regeneration.

Circ Genom Precis Med 2018 Feb;11(2):e002053

From the Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and the Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA.

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February 2018

Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties.

Stem Cells 2018 Dec 5. Epub 2018 Dec 5.

Canadian Blood Services, Centre for Innovation, Ottawa, Ontario, Canada.

Ex vivo expansion of hematopoietic stem cells (HSC) and progenitors may one day overcome the slow platelet engraftment kinetics associated with umbilical cord blood (UCB) transplantation. Serum-free medium conditioned with osteoblasts (i.e. Read More

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December 2018
1 Read

Viral testing of 18 consecutive cases of equine serum hepatitis: A prospective study (2014-2018).

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York.

Background: Three flaviviruses (equine pegivirus [EPgV]; Theiler's disease-associated virus [TDAV]; non-primate hepacivirus [NPHV]) and equine parvovirus (EqPV-H) are present in equine blood products; the TDAV, NPHV, and EqPV-H have been suggested as potential causes of serum hepatitis.

Objective: To determine the prevalence of these viruses in horses with equine serum hepatitis.

Animals: Eighteen horses diagnosed with serum hepatitis, enrolled from US referral hospitals. Read More

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December 2018

ID3 Promotes Stem Cell Features and Predicts Chemotherapeutic Response of Intrahepatic Cholangiocarcinoma.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Cancer stem cells (CSCs) are well contributing to high rate of recurrence and chemotherapeutic resistance in many types of cancer including intrahepatic cholangiocarcinoma (ICC). Inhibitor of differentiation 3 (ID3) has been reported to promote cancer stem cells, but its role in ICC is obscure. In this study, we identified that ID3 is highly expressed in human ICC tissues compared with matched normal tissues and correlates with poor prognosis. Read More

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December 2018

Hepatocyte Nuclear Factor 4 alpha (HNF4α) Activation is Essential for Termination of Liver Regeneration.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Pharmacology, Toxicology and Therapeutics.

Hepatocyte Nuclear Factor 4 alpha (HNF4α) is critical for hepatic differentiation. Recent studies have highlighted its role in inhibition of hepatocyte proliferation and tumor suppression. However, the role of HNF4α in liver regeneration is not known. Read More

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December 2018
1 Read

Revisiting CLEC12A as leukaemic stem cell marker in AML: highlighting the necessity of precision diagnostics in patients eligible for targeted therapy.

Br J Haematol 2018 Dec 5. Epub 2018 Dec 5.

Department of Haematology, Aarhus University Hospital, Aarhus, Denmark.

Targeted therapy directed against rare disease-propagating leukaemic stem cells (LSCs) is a promising prospect for improving the outcome of acute myeloid leukaemia (AML) patients. Thus, distinguishing LSCs from normal haematopoietic stem and progenitor cells (HSPCs) is essential. The CLEC12A receptor has been proposed as a specific marker of LSCs, and consequently as an appealing treatment target. Read More

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December 2018

Doubling rituximab in high-risk patients with aggressive B-cell lymphoma -results of the DENSE-R-MegaCHOEP trial.

Br J Haematol 2018 Dec 5. Epub 2018 Dec 5.

Department of Haematology, Oncology, Haemostaseology, and Pneumology, University Hospital, Münster, Germany.

To further improve outcome in young high-risk patients with diffuse large B-cell lymphoma (DLBCL) the number of rituximab (R) infusions was doubled in combination with standard CHOEP (cyclophosphamide, doxorubicin, etoposide, vincristine, prednisone) chemotherapy. Seventy-seven patients (aged 18-60 years) with an age-adjusted International Prognostic Index of 2-3 received 12 × R (375 mg/m ) on days 0, 1, 4, 8, 15, 22, 29, 43, 57, 71, 85 and 99 together with eight cycles of CHOEP-14. Results were retrospectively compared to those of patients receiving 6 × R and 8 × CHOEP-14 in the standard arm of the randomized R-MegaCHOEP trial. Read More

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December 2018
2 Reads

Phenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses.

Methods Mol Biol 2019 ;1888:21-43

Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.

High-throughput phenotypic screening enables the identification of new therapeutic targets even when the molecular mechanism underlying the disease is unknown. In the case of neurodegenerative disease, there is a dire need to identify new targets that can ameliorate, halt, or reverse degeneration. Stem cell-based disease models are particularly powerful tools for phenotypic screening because they use the same cell type affected in patients. Read More

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January 2019

Hawthorn Extract Alleviates Atherosclerosis through Regulating Inflammation and Apoptosis Related Factors: An Experimental Study.

Chin J Integr Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Objective: To determine the effects of hawthorn extract on serum lipid levels, pathological changes in aortic atherosclerosis plaque, inflammatory factors, and apoptosis-related protein and mRNA expression in apolipoprotein E gene knockout (ApoE) mice.

Methods: Thirty-six ApoE mice were fed with a high-fat diet starting at the age of 8 weeks. Mice were randomly divided into 3 groups by a random number table including model group, hawthorn extract group, and simvastatin group, 12 mice in each group. Read More

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December 2018
1 Read

Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders.

J Mol Neurosci 2018 Dec 5. Epub 2018 Dec 5.

Department of Medical Genetics, Erciyes University Medical Faculty, 38039, Kayseri, Turkey.

Autism spectrum disorder (ASD) is characterized by repetitive stereotypic behaviors, restricted interests, social withdrawal, and communication deficits. Aggression and insensitivity to pain are largely unexplained in these cases. We analyzed nine mRNA expressions of the candidate genes related to aggression and insensitivity to pain in the peripheral blood of patients with ASD. Read More

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December 2018
5 Reads

Vascular density and inflammatory infiltrate in primary oral squamous cell carcinoma and after allogeneic hematopoietic stem cell transplantation.

Ann Hematol 2018 Dec 5. Epub 2018 Dec 5.

Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy.

Hematopoietic stem cell transplantation (HSCT) recipients have been reported to have an increased risk of chronic graft versus host disease (cGVHD) and hematological and solid cancers. Oral manifestations are the first signs of cGVHD observed in the majority of patients, and oropharyngeal cancer is the most frequent secondary malignancy occurred after HSCT. In this study, we have evaluated the inflammatory infiltrate cell content and correlated with the vascular density in patients affected by primary oral squamous cell carcinoma (OSCC) from previous healthy controls and OSCC after cGVHD. Read More

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December 2018
1 Read

Promoter methylation cooperates with SNPs to modulate transcription and alter UC risk.

Biochem Biophys Rep 2019 Mar 20;17:17-22. Epub 2018 Nov 20.

Department of Gynaecology and Obstetrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong, China.

Single-nucleotide polymorphisms (SNPs) located in the promoter region of the receptor for advanced glycation end products () gene have been linked to the activity of RAGE. However, contrary to our expectation, we previously detected no correlation between SNPs within the RAGE promoter and ulcerative colitis (UC) risk in a case-control study. Here, we investigated the methylation of the promoter and analyzed the collective contribution of methylation and SNPs to UC risk. Read More

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March 2019
2 Reads