15,333 results match your criteria Status Epilepticus


Ganaxolone: First Approval.

Authors:
Yvette N Lamb

Drugs 2022 May 21. Epub 2022 May 21.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Ganaxolone (ZTALMY; Marinus Pharmaceuticals) is a synthetic neuroactive steroid that acts as a positive allosteric modulator of the gamma-aminobutyric acid (GABA) receptor complex. Ganaxolone received its first approval in March 2022 in the USA for the treatment of seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) in patients 2 years of age and older. Approval was based on the results of a multinational phase III trial, in which ganaxolone was effective in reducing seizure frequency in children and adolescents with CDD. Read More

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Long-term evolution and prognostic factors of epilepsy in limbic encephalitis with LGI1 antibodies.

J Neurol 2022 May 20. Epub 2022 May 20.

Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and Lyon 1 University, Lyon, France.

Objective: To characterize the evolution of epilepsy in patients with leucine-rich glioma inactivated 1 antibody-associated (LGI1ab) limbic encephalitis, including factors associated with drug-resistant epilepsy (DRE).

Methods: Retrospective analysis of patients with LGI1 encephalitis managed at two tertiary epilepsy centers between 2005 and 2019 and whose samples were confirmed by the French Reference Center of Paraneoplastic Neurological Syndromes. Raw clinical, biological, EEG, and MRI data were reviewed. Read More

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The importance of timing in epilepsia partialis continua.

Neurologia (Engl Ed) 2022 May 6;37(4):263-270. Epub 2021 Apr 6.

Unidad de Epilepsia, Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Introduction: Timing is one of the most important modifiable prognostic factors in the management of status epilepticus. Epilepsia partialis continua (EPC) is a status epilepticus subtype of highly variable, occasionally prolonged, duration. The aim of this study was to analyse the relationship between EPC duration and outcomes. Read More

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Seizures and COVID-19: Results from the Spanish Society of Neurology's COVID-19 registry.

J Clin Neurosci 2022 May 16;101:112-117. Epub 2022 May 16.

Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón, c/ Diego de Velázquez, 1, 28223 Pozuelo de Alarcón, Madrid, Spain.

We describea series of patients with COVID-19 who presented with seizures, reported in the Spanish Society of Neurology's COVID-19 Registry. This observational, descriptive,multicentre, registry-based study includes patients with confirmed COVID-19 who experienced seizures during active infection.Wedescribe theclinicalpresentation of COVID-19,seizures,and resultsof complementary tests. Read More

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Neurological Manifestations of Myocarditis.

Curr Neurol Neurosci Rep 2022 May 19. Epub 2022 May 19.

Department of Neurology and Rehabilitation, University of Illinois at Chicago College of Medicine, 912 S. Wood Street, M/C 796, Chicago, IL, 172C60612, USA.

Purpose Of Review: The present review discusses the neurological complications associated with myocarditis of different etiologies.

Recent Findings: Myocarditis can be idiopathic or caused by different conditions, including toxins, infections, or inflammatory diseases. Clinical findings are variable and range from mild self-limited shortness of breath or chest pain to hemodynamic instability which may result in cardiogenic shock and death. Read More

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Author Correction: Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus.

Nat Rev Neurol 2022 May 18. Epub 2022 May 18.

Neuroscience Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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The case of an 85-year-old female with acute right hemiparesis with status epilepticus.

Ann Clin Transl Neurol 2022 May 18. Epub 2022 May 18.

Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

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Salzburg consensus criteria are associated with long-term outcome after non-convulsive status epilepticus.

Seizure 2022 May 10;99:28-35. Epub 2022 May 10.

Research Unit for Neurology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark. Electronic address:

Purpose: To investigate differences in long-term survival and short-term neurological deficits in adult patients fulfilling either sub-criterion of the Salzburg Consensus Criteria (SC) for non-convulsive status epilepticus (NCSE).

Methods: We retrospectively identified a cohort of patients with first-time NCSE epilepticus at Odense University Hospital from 2014 to 2017. Results of electroencephalograms at admission were dichotomized according to the SC (more than 25 epileptiform discharges/10 s was defined as the fast criterion), and groups were compared statistically through survival analysis and in a logistic regression model adjusting for established prognostic determinants in status epilepticus. Read More

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Bromisoval-induced bromism with status epilepticus mimicking Wernicke's encephalopathy: report of two cases.

BMC Neurol 2022 May 16;22(1):181. Epub 2022 May 16.

Department of Neurology, Nagano Red Cross Hospital, 5-22-1, Wakasato, Nagano, 380-8582, Japan.

Background: Bromine compounds are used in several drugs, including over-the-counter drugs. They sometimes cause intoxication known as bromism. Although the acute neurological symptoms and sequelae of bromism vary, few reports have mentioned acute encephalopathy. Read More

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Non-convulsive Status Epilepticus in -Related Progressive Myoclonic Epilepsy: A Case Report With Literature Review.

Front Pediatr 2022 28;10:859183. Epub 2022 Apr 28.

Department of Neurology, Shenzhen Children's Hospital, Shenzhen, China.

Progressive myoclonic epilepsy (PME) is a group of rare diseases characterized by progressive myoclonus, cognitive impairment, ataxia, and other neurologic deficits. PME has high genetic heterogeneity, and more than 40 genes are reportedly associated with this disorder. encodes a member of the semaphorin family and was first reported to cause PME in 2020. Read More

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Tonic non-colonic convulsions-status epilepticus- as the presenting complaint of COVID-19.

Ann Med Surg (Lond) 2022 May 10:103744. Epub 2022 May 10.

NILE VALLY UNIVERSITY, Atbra, Sudan.

Introduction: COVID19 might present as neurological symptoms including headaches, dizziness, anosmia, stroke, and loss of consciousness. Cases with severe COVID-19 are more likely to be complicated by neurological symptoms, but tonic non-colonic convulsion is still a rare presentation of COVID19 as an initial symptom.

Case Presentation: A 23-years old male presented to the ambulance with a complaint of loss of consciousness for more than 1 h and tonic convulsions without clonic movements. Read More

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Detection of Generalized Tonic-Clonic Seizures in Dogs With a Seizure Detection System Established Using Acceleration Data and the Mahalanobis Distance: A Preliminary Study.

Front Vet Sci 2022 28;9:848604. Epub 2022 Apr 28.

Laboratory of Small Animal Surgery (Neurology), School of Veterinary Medicine, Azabu University, Sagamihara, Japan.

Caregivers of dogs with epilepsy experience severe stress due to unpredictable seizures. Hence, they feel the need for a better management strategy. A seizure detection system (SDS), which can identify seizures and provide notifications to caregivers immediately, is required to address this issue. Read More

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[Convulsive status epilepticus as a possible symptom of COVID-19 in a patient with intellectual disability and autistic spectrum disorder].

Neurologia 2020 Nov-Dec;35(9):703-705. Epub 2020 Jul 31.

Servicio de Neurología, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona. España.

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Disrupted in Schizophrenia 1 Regulates Ectopic Neurogenesis in the Mouse Hilus After Pilocarpine-induced Status Epilepticus.

Neuroscience 2022 May 13. Epub 2022 May 13.

Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China. Electronic address:

Augmentation of neurogenesis and migration of newly born neurons into ectopic regions like the hilus play critical roles during the pathophysiology of acute kindled seizures. Evidence shows that disrupted in schizophrenia 1 (DISC1) has an influence on adult neurogenesis in the dentate gyrus (DG); however, its role of regulating neurogenesis and mispositioned newborn neurons in the hilus after status epilepticus (SE) remains unknown. Using double immunofluorescence staining, the present study clarifies that DISC1 is co-expressed with nearly all of the neuronal markers, which are characterized by different stages of neuronal development, after pilocarpine-induced SE in mice. Read More

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Theta and gamma hippocampal-neocortical oscillations during the episodic-like memory test: Impairment in epileptogenic rats.

Exp Neurol 2022 May 10;354:114110. Epub 2022 May 10.

Institute of Theoretical and Experimental Biophysics Russian Academy of Sciences, Russia.

Cortical oscillations in different frequency bands have been shown to be intimately involved in exploration of environment and cognition. Here, the local field potentials in the hippocampus, the medial prefrontal cortex (mPFC), and the medial entorhinal cortex (mEC) were recorded simultaneously in rats during the execution of the episodic-like memory task. The power of theta (~4-10 Hz), slow gamma (~25-50 Hz), and fast gamma oscillations (~55-100 Hz) was analyzed in all structures examined. Read More

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Unusual neurological presentation of second stage African trypanosomiasis in a young boy: a case report.

BMC Pediatr 2022 May 12;22(1):265. Epub 2022 May 12.

Teaching Assistant, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Gadarif University, Gadarif, Sudan.

Background: In South Sudan, sleeping sickness is a frequent condition caused by human African trypanosomiasis. There are two stages that are well-known. When the CNS is affected, especially with Trypanosoma gambiense infection, the early hemolymphatic stage and the late encephalitic stage have been observed, including mental, motor, and sensory symptoms. Read More

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Purple Glove Syndrome: Recognizing a Rare Complication of Intravenous Phenytoin.

Cureus 2022 Apr 8;14(4):e23958. Epub 2022 Apr 8.

Internal Medicine, Texas Tech University Health Sciences Center, Odessa, USA.

An uncommon but serious adverse drug reaction after phenytoin administration is known as purple glove syndrome (PGS). Initial presentation is characterized by pain, skin discoloration, and edema, that can progress to necrosis. The pathophysiology remains uncertain; however, multiple mechanisms have been reported including extravasation. Read More

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Myoclonic status epilepticus after severe hyperthermia in a patient with coronavirus disease 2019.

Acute Crit Care 2022 Mar 24. Epub 2022 Mar 24.

Section of Neurology, Yale School of Medicine, New Haven, CT, USA.

Myoclonic status epilepticus (MSE) is a sign of severe neurologic injury in cardiac arrest patients. To our knowledge, MSE has not been described as a result of prolonged hyperpyrexia. A 56-yearold man with coronavirus disease 2019 presented with acute respiratory distress syndrome, septic/hypovolemic shock, and presumed community-acquired pneumonia. Read More

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Dopamine depletion in wistar rats with epilepsy.

Braz J Biol 2022 9;84:e248411. Epub 2022 May 9.

Centro Universitário - CESMAC, Campus I, Maceió, AL, Brasil.

The dopamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability period. In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. Susceptibility to pilocarpine-induced status epilepticus (SE), as well as spontaneous and recurrent seizures (SRSs) frequency during the chronic period of the model were determined. Read More

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Ameliorating effect of ketogenic diet on acute status epilepticus: Insights into biochemical and histological changes in rat hippocampus.

J Food Biochem 2022 May 11:e14217. Epub 2022 May 11.

Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

This study aimed to evaluate the potential neuroprotective effects of ketogenic diet (KD) against the neuronal disruptions induced by SE in lithium-pilocarpine rat model of status epilepticus (SE). Four groups of female rats include; groups I and III received standard diet and groups II and IV received KD for 3 weeks. Groups I and II were left untreated, while groups III and IV were injected with LiCl (127 mg/kg, i. Read More

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Comparison of Safety and Effectiveness between Levetiracetam and Phenytoin in the Treatment of Pediatric Status Epilepticus: A meta-analysis.

CNS Neurol Disord Drug Targets 2022 May 9. Epub 2022 May 9.

student in Inaya medical college, Riyadha-SA.

Objectives: To evaluate the safety and effectiveness of levetiracetam and phenytoin by evaluating the events of seizure termination and recurrence in children.

Methods: We used the internet databases PubMed, Embase, and Google Scholar to conduct a literature search for the appropriate studies. A meta-analysis was performed to calculate the odds ratio using fixed and random-effects models. Read More

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Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus.

Nat Rev Neurol 2022 May 10. Epub 2022 May 10.

Neuroscience Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Status epilepticus is a life-threatening neurological emergency that affects both adults and children. Approximately 36% of episodes of status epilepticus do not respond to the current preferred first-line treatment, benzodiazepines. The proportion of episodes that are refractory to benzodiazepines is higher in low-income and middle-income countries (LMICs) than in high-income countries (HICs). Read More

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Fever related super-refractory status epilepticus: An adulthood presentation of a novel POLG variant: A case report.

Seizure 2022 Apr 26;99:24-26. Epub 2022 Apr 26.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka 560 029, India. Electronic address:

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Provoked seizures and status epilepticus in a pediatric population with COVID-19 disease.

Epilepsia 2022 May 9. Epub 2022 May 9.

Departments of Neurology and Pediatrics, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.

We are reporting 16 pediatric patients (ages 0-18-years-old) who presented to our urban hospital emergency room with seizures and coronavirus disease 2019 (COVID-19) during the surge of the Omicron variant. There was an increased number of pediatric patients with seizures and COVID-19 during this period as compared to prior COVID-19 surges. The 16 patients ranged in age from 3 months to 12 years of age. Read More

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Microglia and status epilepticus in the immature brain.

Epilepsia Open 2022 May 9. Epub 2022 May 9.

Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Veracruz, Mexico.

Microglia are the resident immune cells of the Central Nervous System (CNS), which are activated due to brain damage, as part of the neuroinflammatory response. Microglia undergo morphological and biochemical modifications during activation, adopting a pro-inflammatory or an antiinflammatory state. In the developing brain, status epilepticus (SE) promotes microglia activation that is associated with neuronal injury in some areas of the brain, such as the hippocampus, thalamus, and amygdala. Read More

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Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions.

Front Pediatr 2022 21;10:858945. Epub 2022 Apr 21.

Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, AOU "Policlinico", PO "G. Rodolico", Catania, Italy.

In addition to central nervous system infections, seizures and fever may occur together in several neurological disorders. Formerly, based on the clinical features and prognostic evolution, the co-association of seizure and fever included classical febrile seizures (FS) divided into simple, complex, and prolonged FS (also called febrile status epilepticus). Later, this group of disorders has been progressively indicated, with a more inclusive term, as "fever-associated seizures or epilepsy" (FASE) that encompasses: (a) FS divided into simple, complex, and prolonged FS; (b) FS plus; (c) severe myoclonic epilepsy in infancy (Dravet syndrome); (d) genetic epilepsy with FS plus; and (e) febrile infection-related epilepsy syndrome (FIRES). Read More

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Refractory status epilepticus due to vitamin B deficit in a Parkinson's disease patient in treatment with levodopa/carbidopa intestinal gel.

Neurologia (Engl Ed) 2022 May 5. Epub 2022 May 5.

Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

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Landscape of childhood epilepsies - A multi-ethnic population-based study.

Epilepsy Res 2022 Apr 28;183:106936. Epub 2022 Apr 28.

Sidra Medicine, Department of Pediatrics, Division of Pediatric Neurology, Doha, Qatar.

Objective: To describe the clinical features of childhood epilepsy in Qatar.

Methods: A retrospective cross-sectional chart review analysis was conducted at the only tertiary pediatric hospital in Qatar in 1422 patients with epilepsy followed between November 2016 and October 2019.

Results: 55% (781) were males and 70% were non-Qatari. Read More

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Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study.

Epilepsy Res 2022 Apr 21;183:106926. Epub 2022 Apr 21.

Neurobiology Research Unit, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Synaptic Vesicle Glycoprotein 2A (SV2A) has been proposed as a presynaptic marker in several neurological disorders. Not only is SV2A the target for the antiepileptic drug levetiracetam, but also considered a marker of mature pre-synapses. In this study, we aimed to assess the binding of [H]UCB-J as a selective radioligand for SV2A to visualize and determine changes during different stages of epileptogenesis by in-vitro autoradiography in rat models of temporal lobe epilepsy. Read More

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