12,537 results match your criteria Status Epilepticus


Starting ketamine for neuroprotection earlier than its current use as an anesthetic/antiepileptic drug late in refractory status epilepticus.

Epilepsia 2019 Feb 19. Epub 2019 Feb 19.

Neurology Department, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home, North Hills, California.

Ketamine is currently being used as an anesthetic/antiepileptic drug in refractory status epilepticus. To validate its use, 2 clinical trials are recruiting patients. However, preclinical studies of its use in chemically induced status epilepticus in rodents have shown that it is remarkably neuroprotective, through N-methyl-d-aspartate-receptor blockade, even when given after the onset of status epilepticus. Read More

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http://dx.doi.org/10.1111/epi.14676DOI Listing
February 2019

Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion Associated With Adenoviral Pneumonia.

Child Neurol Open 2019 5;6:2329048X19826288. Epub 2019 Feb 5.

Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Acute encephalopathy with biphasic seizures and late reduced diffusion is a subtype of acute encephalopathy described in a cohort of Japanese children. Few cases have been reported in countries other than Japan. It is characterized clinically by biphasic seizures and late reduced subcortical diffusion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1177/2329048X19826288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365989PMC
February 2019

The Neuroprotective Effect of Extracts in Mouse Hippocampus after Pilocarpine-Induced Status Epilepticus.

Int J Mol Sci 2019 Feb 16;20(4). Epub 2019 Feb 16.

Department of Pharmacology, Department of Biomedicine and Health Sciences, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

(HE), a culinary-medicinal mushroom, has shown therapeutic potential in many brain diseases. However, the role of HE in status epilepticus (SE)-mediated neuronal death and its underlying mechanisms remain unclear. We investigated the neuroprotective effects of HE using a pilocarpine-induced SE model. Read More

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http://dx.doi.org/10.3390/ijms20040859DOI Listing
February 2019

Seizure and epilepsy publication in nonneurology journals.

Epilepsy Behav 2019 Feb 16;93:7-11. Epub 2019 Feb 16.

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America; Minnesota Epilepsy Group, P.A., St. Paul, MN, United States of America.

Purpose: The prevalence and characteristics of seizure and epilepsy research published in nonneurology journals are unknown. Characterizing this published research allows for insight into the relevance of seizures and epilepsy in other specialties and may increase opportunity for cross-specialty collaboration.

Methods: In this observational study, we reviewed the top five highly cited clinical journals within eleven specialties in the InCites Journal Citation Reports (JCR) database (2016). Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.032DOI Listing
February 2019

Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome (FIRES).

Ann Neurol 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurology, Mayo Clinic, Rochester, MN, USA, 55905.

Objectives: We recently reported successful treatment of a child with febrile infection-related epilepsy syndrome (FIRES), a subtype of new-onset refractory status epilepticus (NORSE), with the recombinant interleukin-1 (IL1) receptor antagonist (IL1RA) anakinra. On this basis, we tested whether endogenous IL1RA production or function is deficient in FIRES patients.

Methods: Levels of IL1β and IL1RA were measured in serum and CSF. Read More

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http://dx.doi.org/10.1002/ana.25439DOI Listing
February 2019

Status Epilepticus in the Neonate: Updates in Treatment Strategies.

Curr Treat Options Neurol 2019 Feb 18;21(2). Epub 2019 Feb 18.

Division of Neurology, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University, 611 E Livingston Avenue FB4, Columbus, OH, 43205, USA.

Purpose Of Review: The purpose of this review is to report recent advances in treatment of neonatal seizures, with a specific focus on new literature since a 2013 systematic review performed by this author (Slaughter) and others. There is a paucity of data with regard to well-defined status epilepticus (SE) in neonates, so treatment of recurrent seizures was also included in this inquiry. We aimed to summarize the efficacy and safety profiles of current therapeutic options as well as describe trends in medication selection in the neonatal intensive care unit (NICU) setting. Read More

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http://dx.doi.org/10.1007/s11940-019-0546-5DOI Listing
February 2019

[Continuous spike-waves during slow-wave sleep: Experience during 20 years].

An Pediatr (Barc) 2019 Feb 13. Epub 2019 Feb 13.

Sección de Neuropediatría, Hospital Materno Infantil Gregorio Marañón, Madrid, España.

Introduction: Continuous spikes and waves during slow sleep (CSWS) is an EEG pattern that appears during childhood, and is often associated with cognitive impairment. It can appear in the course of epileptic syndromes, as well as in benign epilepsy. The aim of this study is to analyse epidemiological and clinical characteristic of patients with CSWS, in order to describe possible predictive factors in their outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16954033193002
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http://dx.doi.org/10.1016/j.anpedi.2018.12.016DOI Listing
February 2019
1 Read

Functional brain connectivity in electrical status epilepticus in sleep.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Electrical status epilepticus in sleep (ESES) is an age-related, self-limited epileptic encephalopathy. The syndrome is characterized by cognitive and behavioral abnormalities and a specific EEG pattern of continuous spikes and waves during slow-wave sleep. While spikes and sharp waves are known to result in transient cognitive impairment during learning and memory tasks performed during the waking state, the effect of epileptiform discharges during sleep on cognition and behavior is unclear. Read More

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http://dx.doi.org/10.1684/epd.2019.1027DOI Listing
February 2019

Focal visual status epilepticus.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Department for Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany.

Epileptic visual auras are elementary to complex and sometimes occur as colourful visual phenomena located close to or within the central part of the contralateral hemi-field. They typically last from seconds to a few minutes, which discriminates them from the usually longer-lasting visual auras (5-30 minutes) of patients suffering from migraine. We present an adult patient with occipital lobe epilepsy whose visual aura under epilepsy monitoring lasted for more than 30 minutes with almost no propagation, demonstrating a rare, but remarkable, sustained local epileptic network activity associated with resection of an occipital arterio-venous malformation. Read More

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http://dx.doi.org/10.1684/epd.2019.1034DOI Listing
February 2019

A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatric Epilepsy, Beaumont Health, Royal Oak, MI 48073.

Dynamin-1-like protein (DNM1L) gene variants have been linked to childhood refractory epilepsy, developmental delay, encephalopathy, microcephaly, and progressive diffuse cerebral atrophy. However, only a few cases have been reported in the literature and there is still a limited amount of information about the symptomatology and pathophysiology associated with pathogenic variants of DNM1L. We report a 10-year-old girl with a one-year history of mild learning disorder and absence seizures who presented with new-onset focal status epilepticus which progressed to severe encephalopathy and asymmetric hemispheric cerebral atrophy. Read More

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http://dx.doi.org/10.1684/epd.2019.1036DOI Listing
February 2019
1 Read

Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.

Neuropharmacology 2019 Feb 11. Epub 2019 Feb 11.

DepartmenSt of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, USA.

Glutamate receptor-mediated excitotoxicity is a common pathogenic process in many neurological conditions including epilepsy. Prolonged seizures induce elevations in extracellular glutamate that contribute to excitotoxic damage, which in turn can trigger chronic neuroinflammatory reactions, leading to secondary damage to the brain. Blocking key inflammatory pathways could prevent such secondary brain injury following the initial excitotoxic insults. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.011DOI Listing
February 2019
1 Read

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019
1 Read

Posterior Reversible Encephalopathy Syndrome and Azathioprine.

Eur J Case Rep Intern Med 2019 25;6(1):001032. Epub 2019 Jan 25.

Serviço Medicina III, Hospital Prof. Doutor Fernando Fonseca, Lisbon, Portugal.

Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension. Magnetic resonance imaging (MRI) shows bilateral white matter oedema in the posterior vascular territories. Immunosuppression, (pre) eclampsia and autoimmune diseases can be implicated. Read More

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http://dx.doi.org/10.12890/2019_001032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372047PMC
January 2019
2 Reads

Annexin A1-derived peptide Ac in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects.

J Neuroinflammation 2019 Feb 12;16(1):32. Epub 2019 Feb 12.

Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.

Background: The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac in an experimental model of status epilepticus (SE) was evaluated. Read More

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http://dx.doi.org/10.1186/s12974-019-1414-7DOI Listing
February 2019
2 Reads

Emergency Management of Epilepsy and Seizures.

Semin Neurol 2019 Feb 11;39(1):73-81. Epub 2019 Feb 11.

Department of Neurology, Columbia University Medical Center, New York, New York.

Seizure- and epilepsy-related complications are a common cause of emergency medical evaluation, accounting for 5% of 911 calls and 1% of emergency department visits. Emergency physicians and neurologists must be able to recognize and treat seizure- and epilepsy-related emergencies. This review describes the emergency evaluation and management of new onset seizures, breakthrough seizures in patients with known epilepsy, status epilepticus, acute symptomatic seizures, and acute adverse effects of antiepileptic drugs. Read More

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http://dx.doi.org/10.1055/s-0038-1677008DOI Listing
February 2019
1 Read

Effects of High- and Low-Frequency Stimulation of the Thalamic Reticular Nucleus on Pentylentetrazole-Induced Seizures in Rats.

Neuromodulation 2019 Feb 11. Epub 2019 Feb 11.

Laboratorio de Neurofisiología del Control y la Regulación. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico.

Rationale: The use of electrical stimulation therapy to treat epilepsy is currently being studied in experimental animals and patients. Our study was designed to evaluate the effects of electrical stimulation applied in the thalamic reticular nucleus (TRN) on the development of pentylentetrazole-induced seizures.

Materials And Methods: Experiments were performed using male Wistar rats with electrodes stereotaxically implanted in the left TRN. Read More

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http://dx.doi.org/10.1111/ner.12926DOI Listing
February 2019
1 Read

Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.

Brain Res Bull 2019 Feb 7;147:22-35. Epub 2019 Feb 7.

Institute of Information and Communication Technologies, BAS, Sofia, Bulgaria.

Recently, we have reported that while agomelatine (Ago) is unable to prevent development of epilepsy it exerts a strong neuroprotective and anti-inflammatory response in the KA post-status epilepticus (SE) rat model. In the present study, we aimed to explore whether the brain-derived neurotrophic factor (BDNF) in the hippocampus is involved in the neuroprotective effect of Ago against the KA-induced SE and epileptiform activity four months later in rats. Lacosamide (LCM) was used as a positive control. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.017DOI Listing
February 2019
1 Read

Predictive factors and prognostic value for status epilepticus in newborns.

Eur J Paediatr Neurol 2019 Jan 29. Epub 2019 Jan 29.

Epileptology, Sleep Disorders and Functional Pediatric Neurology, Member of ERN-EpiCARE; HFME, Hospices Civils de Lyon, 59 Boulevard Pinel, Bron, France.

Objectives: To evaluate the predictive factors for status epilepticus (SE) in neonates and prognostic factors for patient outcomes in newborns suffering either isolated seizures or SE.

Methods: A retrospective single-center study from January 2010 to December 2014, included 91 newborns who had neonatal seizures. Among them, 50 newborns experienced SE and 41 newborns presented isolated seizures only. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.006DOI Listing
January 2019
2 Reads

Electrical cortical stimulation for refractory focal epilepsy: A long-term follow-up study.

Epilepsy Res 2019 Jan 9;151:24-30. Epub 2019 Jan 9.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan; Department of Neurology, Xiamen Changgung Hospital, China. Electronic address:

Objective: To report the long-term seizure control and safety of open-loop electrical cortical stimulation in patients with refractory focal epilepsy of diverse etiologies.

Methods: Six patients who received a therapeutic trial of cortical stimulation were included retrospectively. The frequency of seizures was recorded before and after implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183049
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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.003DOI Listing
January 2019
8 Reads
2.015 Impact Factor

Status epilepticus after C-4 ingestion: using liquid chromatography to quantify toxicity.

Clin Toxicol (Phila) 2019 Feb 7:1-3. Epub 2019 Feb 7.

c Department of Neurology , William Beaumont Army Medical Center , El Paso , TX , USA.

Context: C-4, a commonly used explosive in military operations, is sometimes consumed by soldiers as a rite of passage. The primary component of C-4 is cyclotrimethylenetrinitramine, or Research Department Explosive (RDX), which causes euphoria along with nausea, vomiting, renal injury, encephalopathy and convulsions when consumed in toxic amounts. We present a case of status epilepticus caused by known ingestion of C-4, in which serum levels of the compound were measured with high-performance liquid chromatography (HPLC). Read More

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http://dx.doi.org/10.1080/15563650.2018.1562069DOI Listing
February 2019
1 Read

Use of Newer Anticonvulsants for the Treatment of Status Epilepticus.

Pharmacotherapy 2019 Feb 5. Epub 2019 Feb 5.

University of Illinois at Chicago, Department of Pharmacy Practice, Chicago, IL.

Status Epilepticus (SE) has a high mortality rate and is one of the most common neurological emergencies. Fast progression of this neurological emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. The objective of this paper was to evaluate the efficacy and safety of AEDs released to the market after 2000 for SE, refractory SE (RSE), and super refractory SE (SRSE). Read More

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http://dx.doi.org/10.1002/phar.2229DOI Listing
February 2019
1 Read

Effect of Co-administration of Bumetanide and Phenobarbital on Seizure Attacks in Temporal Lobe Epilepsy.

Basic Clin Neurosci 2018 Nov-Dec;9(6):408-416. Epub 2018 Nov 1.

Department of Tissue Engineering & Regenerative Medicine, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: The resistance of temporal lobe epilepsy to classic drugs is thought to be due to disruption in the excitation/inhibition of this pathway. Two chloride transporters, NKCC1 and KCC2, are expressed differently for the excitatory state of Gamma-Amino Butyric Acid (GABA). The present study explored the effect of bumetanide as a selective NKCC1 inhibitor either alone or in combination with the phenobarbital in the pilocarpine model of epilepsy. Read More

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http://bcn.iums.ac.ir/article-1-826-en.html
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http://dx.doi.org/10.32598/bcn.9.6.408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359685PMC
November 2018
2 Reads

Effects of Jobelyn on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice.

Basic Clin Neurosci 2018 Nov-Dec;9(6):389-396. Epub 2018 Nov 3.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: Isoniazid-induced seizure, often described as Status Epilepticus (SE), is an emergency condition characterized by repeated convulsive episodes that responds poorly to the currently available anticonvulsant drugs. The current study aimed at ascertaining the effect of Jobelyn (JB), an African dietary supplement, on seizures, altered oxidative stress, and glutamate decarboxylase activity induced by isoniazid in mice.

Methods: A total of 6 mice received JB (10-50 mg/kg, PO), pyridoxine (300 mg/kg), diazepam (5 mg/kg), or distilled water (10 mL/kg) 30 minutes prior to the induction of SE with injection of isoniazid (300 mg/kg, IP). Read More

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http://dx.doi.org/10.32598/bcn.9.6.389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359684PMC
November 2018
2 Reads

Risk Factors for Nonconvulsive Status Epilepticus after Stroke.

Eur Neurol 2019 Feb 4;80(5-6):256-260. Epub 2019 Feb 4.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

Background: Status epilepticus (SE) sometimes occurs after stroke. SE is classified as convulsive SE (CSE) and nonconvulsive SE (NCSE). Clinical characteristics, outcomes, mortality, and recurrences of post-stroke NCSE are yet to be clarified. Read More

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http://dx.doi.org/10.1159/000496512DOI Listing
February 2019
1 Read

Synergistic action of CB and 5-HT receptors in preventing pilocarpine-induced status epilepticus in rats.

Neurobiol Dis 2019 Feb 1;125:135-145. Epub 2019 Feb 1.

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; School of Biosciences, Cardiff University, Cardiff, UK. Electronic address:

Endocannabinoids (eCBs) and serotonin (5-HT) play a neuromodulatory role in the central nervous system. Both eCBs and 5-HT regulate neuronal excitability and their pharmacological potentiation has been shown to control seizures in pre-clinical and human studies. Compelling evidence indicates that eCB and 5-HT systems interact to modulate several physiological and pathological brain functions, such as food intake, pain, drug addiction, depression, and anxiety. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.01.026DOI Listing
February 2019
2 Reads

Protective role of sitagliptin against oxidative stress in a kainic acid-induced status epilepticus in rats models via Nrf2/HO-1 pathway.

Drug Dev Res 2019 Feb 4. Epub 2019 Feb 4.

Biotech Center for Viral Disease Emergency, National Institute for Disease Control and Prevention, Chinese Disease Control and Prevention, Beijing, China.

Preclinical Research & Development Aim: Sitagliptin (Sita) is a dipeptidyl peptidase-4 inhibitor which has been approved as a curing medicine for Type 2 diabetes (T2D) and has also reported its neuroprotective and antioxidant activity. This article describes the therapeutic effects of Sita on induced rat model of SE by kainic acid (KA) and investigated the antioxidative pathway of sita.

Methods: Sprague-Dawley male rats were used randomly divided in four groups: vehicle control, KA and Sita + KA in a 5 and 10 mg/kg doses respectively in further groups. Read More

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http://dx.doi.org/10.1002/ddr.21516DOI Listing
February 2019

The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.

Brain Res 2019 Jan 29. Epub 2019 Jan 29.

Neurology department of the First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Objective: The putative neuroprotective and disease-modifying effects of lamotrigine (LTG) and ethosuximide (ESM) were investigated in the lithium-pilocarpine (Li-Pc) model of temporal-lobe epilepsy (TLE) in rats. Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed.

Methods: Status Epilepticus (SE) was induced by Li-Pc in five experimental groups: 24 h after SE, all rats received twice daily either a low (10 mg/kg) or high (20 mg/kg) dose of LTG, or a low (25 mg/kg) or high (50 mg/kg) dose of ESM, or solvent. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.01.031DOI Listing
January 2019
3 Reads
2.843 Impact Factor

Adult-onset Rasmussen's Syndrome with associated cortical dysplasia.

Epilepsy Behav Case Rep 2019 28;11:54-57. Epub 2018 Nov 28.

Department of Neurosurgery, UT Health San Antonio, San Antonio, TX, United States of America.

We describe a 23-year-old woman with previous right temporal lobe surgeries for underlying cortical dysplasia, presenting with right hemispheric seizures and epilepsia partialis continua (EPC). After anti-seizure medication adjustments, she developed focal status epilepticus with progressive EEG and neuroimaging changes. Cerebrospinal fluid and serum autoimmune panels were negative except for an elevated serum acetylcholine-receptor antibody titer, but she underwent immunosuppressive therapy. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349012PMC
November 2018
5 Reads

Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.

Brain Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

Chemically or electrically induced status epilepticus (SE) in rodents is a commonly used method for induction of epilepsy. Structural and functional changes in the hippocampus play a pivotal role in epileptogenesis induced by SE. Although cholinergic mechanisms have long been thought to play an important role in the onset and propagation of epileptic seizures, not much is known about the potential role of acetylcholine (ACh) in ictogenesis and epileptogenesis in SE models of temporal lobe epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193005
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http://dx.doi.org/10.1016/j.brainres.2019.01.034DOI Listing
January 2019
4 Reads

[Subcortical calcification on CT in Borden type III intracranial dural arteriovenous fistula].

Rinsho Shinkeigaku 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Nissan Tamagawa Hospital.

We herein report a 67-year-old female who presented with progressive dementia and disturbance of consciousness. Brain CT showed multiple subcortical calcifications with edema. Enhanced CT showed multiple abnormal vessels in the left hemisphere. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001200DOI Listing
January 2019
2 Reads

Takotsubo cardiomyopathy triggered by status epilepticus: case report and literature review.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Cardiology, The Northern Health, Epping, Victoria, Australia.

Takotsubo cardiomyopathy (TC) is acute stress-induced cardiomyopathy with characteristic transient wall motion abnormalities. TC has a clinical presentation similar to an acute coronary syndrome, including chest pain or dyspnoea, ECG changes and elevated cardiac enzymes. TC often occurs after emotional stress. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22592
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http://dx.doi.org/10.1136/bcr-2018-225924DOI Listing
January 2019
1 Read

[Rhythmic and periodic EEG patterns. Classification and clinical significance.]

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10. Vyp. 2):9-20

Evdokimov Moscow State University of Medical Dentistry, Moscow, Russia; Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia.

The review presents the methodology of electroencephalography (EEG) background analysis, sporadic epileptiform discharges classification, and description of the rhythmic and periodic patterns in patients with primary and secondary brain damage. It describes the process of decision making in starting non-convulsive status epilepticus treatment of patients with EEG-verified non-convulsive status epilepticus and the signs of 'malignant' patterns indicating the irreversibility of brain injury. Read More

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http://dx.doi.org/10.17116/jnevro20181181029DOI Listing
January 2018
1 Read

Clinical and EEG Characteristics of Ifosfamide-Related Encephalopathy.

J Clin Neurophysiol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

Purpose: Ifosfamide can lead to a syndrome of central nervous system toxicity. Here, we investigate the clinical and EEG characteristics of patients with ifosfamide-related encephalopathy.

Methods: Retrospective data were collected on patients from Memorial Sloan Kettering Cancer Center, who developed encephalopathy associated with ifosfamide between 2007 and 2017. Read More

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http://Insights.ovid.com/crossref?an=00004691-900000000-9948
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http://dx.doi.org/10.1097/WNP.0000000000000539DOI Listing
January 2019
1 Read

Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment.

J Mol Neurosci 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, Fujian Medical University Union Hospital, Xinquan Road 29#, Fuzhou, 350001, China.

Cognitive impairment is a common comorbidity in patients with temporal lobe epilepsy (TLE) that severely affects patients' quality of life. Also, serotonin 5-hydroxytryptamine 6 (5-HT6) receptor plays an important role in cognition. This study aimed to investigate effects of 5-HT6 receptor on learning-memory capacities in epileptic rats. Read More

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http://link.springer.com/10.1007/s12031-018-1238-4
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http://dx.doi.org/10.1007/s12031-018-1238-4DOI Listing
January 2019
3 Reads

Determinants of Outcome in Convulsive Status Epilepticus in Adults: An Ambispective Study from Central India.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):84-90

Department of Neurology, Sri Aurobindo Medical College and P.G. Institute, Indore, Madhya Pradesh, India.

Background: The determinants of the outcome in adult convulsive status epilepticus(CSE), also the implication of the value of mean arterial blood pressure (MAP), and random blood sugar at admission on the outcome are not clear.

Objectives: The objective of this study is to look for the determinants of unfavorable outcome in CSE.

Materials And Methods: Ambispectively gathered data from 55 patients, treated consecutively with identical protocol during January 2010-December 2016, were analyzed. Read More

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http://dx.doi.org/10.4103/aian.AIAN_466_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327706PMC
January 2019
0.514 Impact Factor

Comment regarding: "Predictors of long-term mortality in status epilepticus".

Epilepsy Behav 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurology, Odense University Hospital, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2018.09.031DOI Listing
January 2019

Refractory status epilepticus in adults admitted to ITU in Glasgow 1995-2013 a longitudinal audit highlighting the need for action for provoked and unprovoked status epilepticus.

Seizure 2019 Feb 14;65:138-143. Epub 2019 Jan 14.

Department of Neurology, Institute of Neurosciences, Queen Elizabeth University Hospital, Glasgow, G51 4TF, United Kingdom; School of Medicine, Wolfson Medical School Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. Electronic address:

Purpose: Our primary objective was to determine incidence of status epilepticus in adults admitted to 5 ITU settings in Glasgow over 18 years. We wanted to investigate if there are any change in causes and outcomes of SE over last decade. We also compared outcomes of De Novo statuts Epilpeticus (DNSE) and Stauts Epilepticus in patients with previous Epilepsy (SEPE). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.011DOI Listing
February 2019

Baclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Royal Perth Hospital, Perth, Australia.

Purpose: Baclofen has been reported to cause both a metabolic encephalopathy and nonconvulsive status epilepticus. Baclofen is typically used in the management of muscle spasticity but is being increasingly used to manage alcohol withdrawal and opiate dependency. Given the increasing use of baclofen we describe the clinical and electrographical features of baclofen neurotoxicity seen at our institution. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000565DOI Listing
January 2019
2 Reads

Use of Continuous EEG Monitoring in Children Presenting With Encephalopathy Following Convulsive Status Epilepticus.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, U.S.A.

Purpose: The Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society recommends continuous EEG (cEEG) monitoring in patients with persistent encephalopathy following convulsive status epilepticus. This recommendation is based on data, which correlates prolonged nonconvulsive seizures and nonconvulsive status epilepticus with worse neurologic outcomes. Compliance with these recommendations may be limited by barriers such as inadequate resource and staff availability. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000566DOI Listing
January 2019
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Serious central nervous system side effects of cephalosporins: A national analysis of serious reports registered in the French Pharmacovigilance Database.

J Neurol Sci 2019 Jan 16. Epub 2019 Jan 16.

Centre Régional de Pharmacovigilance, Service de Pharmacologie Clinique et Pharmacovigilance, APHM, INSERM, Inst Neurosci Syst, Aix Marseille Univ, Marseille, France. Electronic address:

Introduction: Among antibiotics, Central Nervous System (CNS) adverse drug reactions (ADRs) are often under-suspected and overlooked. Cephalosporins are an important cause of drug-induced CNS ADRs but the characteristics of such ADR have not been fully explored. We aimed to characterize the profile of cephalosporins serious CNS ADRs. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.018DOI Listing
January 2019
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Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with generalized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study.

Seizure 2019 Feb 15;65:111-117. Epub 2019 Jan 15.

Department of Neurology, National Institute of Mental Health and NeuroSciences (NIMHANS), Bangalore, India. Electronic address:

Purpose: This randomized control study was conducted to compare the efficacy of sodium valproate (SVP) and levetiracetam (LEV) following initial intravenous lorazepam in elderly patients (age: >60years) with generalized convulsive status epilepticus (GCSE) and to identify predictors of poor seizure control.

Methods: A total of 118 patients (mean age: 67.5 ± 7. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.015DOI Listing
February 2019
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Neurosurgical therapy for Status Epilepticus in Oligoastrocytoma Patient: A case report.

World Neurosurg 2019 Jan 22. Epub 2019 Jan 22.

Epilepsy Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.

Background: Super refractory epilepticus status (SRSE) is a life-threatening neurologic emergency defined as 'status epilepticus (SE) that continues 24 hours or more after the onset of anaesthesia, including those cases in which the SE recurs on the reduction or withdrawal of anaesthesia', which occur in 10-15% of SE patients and rarely has been resolved surgically.

Methods: A 20-year-old man with SRSE and a long history of left parieto-occipital oligoastrocytoma was admitted for convulsive SE that become SRSE and underwent lesionectomy guided by electrocorticography and neuro-navigation for local tumor recurrence. Histopathological diagnosis was oligoastrocytoma. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.027DOI Listing
January 2019
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FDG-PET and MRI in the Evolution of New-Onset Refractory Status Epilepticus.

AJNR Am J Neuroradiol 2019 Feb 24;40(2):238-244. Epub 2019 Jan 24.

Department of Nuclear Medicine (G.W., M.L.).

Background And Purpose: New-onset refractory status epilepticus is a clinical condition characterized by acute and prolonged pharmacoresistant seizures without a pre-existing relevant neurologic disorder, prior epilepsy, or clear structural, toxic, or metabolic cause. New-onset refractory status epilepticus is often associated with antineuronal antibodies and may respond to early immunosuppressive therapy, reflecting an inflammatory element of the condition. FDG-PET is a useful diagnostic tool in inflammatory and noninflammatory encephalitis. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A5929
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http://dx.doi.org/10.3174/ajnr.A5929DOI Listing
February 2019
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Intracranial ectopic choroid plexus cyst in a dog.

J Vet Med Sci 2019 Jan 23. Epub 2019 Jan 23.

Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University.

A 4-year-old male Toy Poodle was presented with a history of status epilepticus. On presentation, neurological examination revealed a delay in postural reactions in the right pelvic limb. Magnetic resonance imaging showed a fluid-containing cystic lesion that compressed the mesencephalon, hippocampus, and amygdala. Read More

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http://dx.doi.org/10.1292/jvms.18-0244DOI Listing
January 2019

[Emergency management and medical care of adults with first epileptic seizures].

Dtsch Med Wochenschr 2019 Jan 23;144(2):83-92. Epub 2019 Jan 23.

Suspected epileptic seizures are a frequent cause of emergency hospital care. After single seizures, the emergency management includes safety measures and diagnostic efforts to distinguish epileptic seizures from its manifold mimics and to possibly detect acute causes of epileptic seizures. Convulsive status epilepticus requires rapid anticonvulsant treatment according to established protocols and diagnostics to rule out underlying acute brain diseases. Read More

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http://dx.doi.org/10.1055/a-0660-3174DOI Listing
January 2019

Factors affecting epilepsy prognosis in patients with tuberous sclerosis.

Childs Nerv Syst 2019 Mar 23;35(3):463-468. Epub 2019 Jan 23.

Department of Biostatistics, Cukurova University, Adana, Turkey.

Purpose: We aimed to determine the characteristics of epileptic seizures that significantly affect the cognitive functions of 83 patients followed with tuberous sclerosis complex (TSC), their resistance to treatment and risk factors causing this resistance.

Materials-methods: In order to determine the prognosis, the seizure-free/seizure-controlled group and the group with refractory seizures were compared. In addition, risk factors affecting cognitive functions in the patients were determined. Read More

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http://link.springer.com/10.1007/s00381-019-04066-7
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http://dx.doi.org/10.1007/s00381-019-04066-7DOI Listing
March 2019
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Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.

Hippocampus 2019 Jan 23. Epub 2019 Jan 23.

Center for Dementia Research, The Nathan Kline Institute of Psychiatric Research, Orangeburg, New York.

Previous studies suggest that reducing the numbers of adult-born neurons in the dentate gyrus (DG) of the mouse increases susceptibility to severe continuous seizures (status epilepticus; SE) evoked by systemic injection of the convulsant kainic acid (KA). However, it was not clear if the results would be the same for other ways to induce seizures, or if SE-induced damage would be affected. Therefore, we used pilocarpine, which induces seizures by a different mechanism than KA. Read More

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http://doi.wiley.com/10.1002/hipo.23062
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http://dx.doi.org/10.1002/hipo.23062DOI Listing
January 2019
3 Reads
4.162 Impact Factor

Nonconvulsive status epilepticus secondary to acute porphyria crisis.

Epilepsy Behav Case Rep 2019 28;11:43-46. Epub 2018 Nov 28.

Department of Neurology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Both variegate and acute intermittent porphyria can manifest with various neurological symptoms. Although acute symptomatic seizures have been previously described, they are typically tonic-clonic and focal impaired awareness seizures. Convulsive status epilepticus and epilepsia partialis continua are rare and have been described on a case report basis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
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http://dx.doi.org/10.1016/j.ebcr.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327909PMC
November 2018
10 Reads