13,593 results match your criteria Status Epilepticus


Patient and Surrogate Postenrollment Perspectives on Research Using the Exception From Informed Consent: An Integrated Survey.

Ann Emerg Med 2020 May 20. Epub 2020 May 20.

Emory University School of Medicine, Atlanta, GA; Emory University Rollins School of Public Health, Atlanta, GA.

Study Objective: It is important for researchers interested in trials using the exception from informed consent to understand the views and experiences of enrolled individuals. Previous studies have shown that patient and surrogate attitudes are generally positive. These studies were small and did not include pediatric patients, and interviews were often conducted long after trial enrollment. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2020.03.017DOI Listing

Continuous Electroencephalography Monitoring in Critically Ill Infants and Children.

Pediatr Neurol 2020 Apr 26. Epub 2020 Apr 26.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.

Continuous video electroencephalography (CEEG) monitoring of critically ill infants and children has expanded rapidly in recent years. Indications for CEEG include evaluation of patients with altered mental status, characterization of paroxysmal events, and detection of electrographic seizures, including monitoring of patients with limited neurological examination or conditions that put them at high risk for electrographic seizures (e.g. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2020.04.009DOI Listing

Neuroprotective Effects of Lacosamide and Memantine on Hyperoxic Brain Injury in Rats.

Neurochem Res 2020 May 22. Epub 2020 May 22.

Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

In neonates supraphysiological oxygen therapy has been demonstrated to cause neuronal death in hippocampus, prefrontal cortex, parietal cortex, and retrosplenial cortex. There is a need for the detection of novel neuroprotective drugs. Neuroprotective effects of lacosamide or memantine have been demonstrated in adult patients with ischemia, trauma and status epilepticus. Read More

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http://dx.doi.org/10.1007/s11064-020-03056-5DOI Listing

Antiepileptic drugs for acute encephalitic patients presented with seizure.

Epilepsy Res 2020 May 19;164:106347. Epub 2020 May 19.

Department of Neurology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:

Objective: The aim of this study was to clarify the pattern and efficacy of antiepileptic drugs (AEDs) in acute encephalitis and discuss how long AEDs should be used after the acute phase.

Methods: Patients with acute encephalitis who presented with seizure were enrolled. The clinical features were systematically gathered, and the information about AEDs and seizures was obtained by a clinical follow-up and (or) a telephone interview based on a structured form. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106347DOI Listing

Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury.

Neurobiol Dis 2020 May 19:104949. Epub 2020 May 19.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and function and potential strategies to mitigate adverse consequences of SE. An acute 2 h episode of FSE was induced in anesthetized mice by epidural application of gabazine +4-aminopyridine over sensorimotor neocortex. Read More

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http://dx.doi.org/10.1016/j.nbd.2020.104949DOI Listing

Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons.

J Ethnopharmacol 2020 May 19. Epub 2020 May 19.

Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, NO.300, Xueshi Road, Changsha, Hunan Province, 410208, China. Electronic address:

Ethnopharmacological Relevance: Chaihu-Longgu-Muli decoction (CLMD) is a well-known ancient formula in traditional Chinese medicine (TCM) to relieve disorder, clear away heat, tranquilize the mind and allay excitement. It has been used for the therapy of neuropsychiatric disorders such as epilepsy, dementia, insomnia, anxiety, and depression for several centuries in China.

Aim Of The Study: This paper is based on the assumption that the mechanism by which CLMD relieves epileptic symptoms in rats is associated with improving autophagy. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112990DOI Listing

Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice.

Exp Cell Res 2020 May 18:112089. Epub 2020 May 18.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, PR China.

MicroRNAs (miRNAs) are reported to involve in pathogenesis of temporal lobe epilepsy (TLE). miR-142-5p is found increased in TLE, but its role remains unknown. In the study, we established a mouse model of status epilepticus (SE) with pilocarpine and a cell model of TLE. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112089DOI Listing

Aphasic status epilepticus of frontal origin treated by resective surgery.

Epilepsy Behav Rep 2020 23;14:100359. Epub 2020 Mar 23.

Department of Neurological Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan.

Aphasic status epilepticus (SE) is a clinical entity of SE, but it has not been well recognized. We report a 43-year-old female with a chronic drug-resistant epilepsy with aphasic SE, treated by resective surgery. The patient showed long-lasting weekly episodes of hypokinesia, slow verbal response, and dysphasia, which were diagnosed as symptoms of aphasic SE. Read More

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http://dx.doi.org/10.1016/j.ebr.2020.100359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229485PMC

New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report.

SN Compr Clin Med 2020 28;2(1):103-107. Epub 2019 Nov 28.

3Department of Anesthesiology, Department of Hearing and Speech Sciences, Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN USA.

Management of new-onset refractory status epilepticus and the approach to burst suppression variable is often challenging. We present the unusual case of a previously healthy 18-year-old male with new-onset status epilepticus admitted to the neurologic intensive care unit for 70 days. Despite treatment with multiple anti-epileptic drugs in addition to IV anesthetics, burst suppression was initially unsustainable and the patient remained in super-refractory status epilepticus. Read More

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http://dx.doi.org/10.1007/s42399-019-00185-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223986PMC
November 2019

Systemic lupus erythematosus presenting with status epilepticus and acute cardiomyopathy with acute heart failure: case report.

Egypt J Neurol Psychiatr Neurosurg 2020 29;56(1):15. Epub 2020 Jan 29.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Introduction: Systemic lupus erythematosus is a connective tissue disorder, which causes complex multi organ involvement. Neurological and cardiac manifestations have been well noted but complications such as status epilepticus and acute myocarditis with heart failure at presentation remains uncommon.

Case Description: A 15-year-old, previously healthy, South Asian, Sri Lankan female presented with status epilepticus and the seizures only responded to intravenous midazolam and thiopentone sodium. Read More

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http://dx.doi.org/10.1186/s41983-020-0149-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223658PMC
January 2020

[Non-convulsive Status Epilepticus Following Clipping of Ruptured Cerebral Aneurysms].

No Shinkei Geka 2020 May;48(5):451-457

Department of Neurosurgery, Japanese Red Cross Fukui Hospital.

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http://dx.doi.org/10.11477/mf.1436204208DOI Listing

Refractory status epilepticus in genetic Creutzfeldt-Jakob disease with E200K mutation.

Neurologia 2020 May 17. Epub 2020 May 17.

Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.nrl.2020.04.013DOI Listing

Pilocarpine-induced status epilepticus reduces chemosensory control of breathing.

Brain Res Bull 2020 May 17;161:98-105. Epub 2020 May 17.

Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof Lineu Prestes Av 05508-000, Sao Paulo, SP, Brazil. Electronic address:

One of the possible causes of death in epilepsy is breathing disorders, especially apneas, which lead to an increase in CO levels (hypercapnia) and/or a decrease in O levels in arterial blood (hypoxemia). The respiratory neurons located in the ventral brainstem respiratory column are the main groups responsible for controlling breathing. Recent data from our group demonstrated respiratory changes in two experimental models of epilepsy, i. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2020.05.002DOI Listing

In-vitro and in-vivo evaluation of chitosan-based thermosensitive gel containing lorazepam NLCs for the treatment of status epilepticus.

IET Nanobiotechnol 2020 Apr;14(2):148-154

Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.

The objective of this study was to develop an in-situ gel containing lorazepam (LZM) loaded nanostructured lipid carriers (NLCs) for direct nose-to-brain delivery in order to increase drug therapeutic efficacy in the treatment of epilepsy. Accordingly, LZM loaded NLCs were formulated using emulsification solvent diffusion and evaporation method; then the effects of the formulation variables on different physicochemical characteristics of NLCs were investigated. Thermosensitive in-situ gels containing LZM-NLCs were prepared using a combination of chitosan and β-glycerol phosphate (β-GP). Read More

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http://dx.doi.org/10.1049/iet-nbt.2019.0156DOI Listing

Clinical and Electroencephalographic Features of the Seizures in Neuronal Surface Antibody-Associated Autoimmune Encephalitis.

Front Neurol 2020 5;11:280. Epub 2020 May 5.

Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

To investigate clinical and electroencephalographic features of the seizures in different types of neuronal surface antibody (NSAb)-associated autoimmune encephalitis (AE). The clinical data of the seizures were analyzed in 18 patients with NSAb-associated AEs diagnosed in the First Affiliated Hospital of Dalian Medical University. From May 2013 to April 2019, a total of 18 cases of NSAb-associated AE were diagnosed, including 9 cases of leucine-rich glioma-inactivated 1 protein (LGI1) antibody-associated encephalitis, 7 cases of anti--methyl-d-aspartate receptor (NMDAR) encephalitis, and 2 cases of anti-γ-aminobutyric acid B receptor (GABAR) encephalitis. Read More

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http://dx.doi.org/10.3389/fneur.2020.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214674PMC

Astaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal.

Drug Des Devel Ther 2020 30;14:1651-1662. Epub 2020 Apr 30.

Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, People's Republic of China.

Background: As a life-threatening neurological emergency, status epilepticus (SE) is often refractory to available treatment. Current studies have shown a causal role of neuroinflammation in patients with lower seizure thresholds and driving seizures. The ATP-gated purinergic P2X7 receptor (P2X7R) is mainly expressed on the microglia, which function as gatekeepers of inflammation. Read More

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http://dx.doi.org/10.2147/DDDT.S249162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201036PMC

Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy: Involvement of oxidative stress, inflammation and pyroptosis.

J Chem Neuroanat 2020 May 8:101800. Epub 2020 May 8.

Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Oxidative stress, inflammation and pyroptosis are three of the most important mechanisms in the pathophysiology of temporal lobe epilepsy (TLE). Most people with TLE are refractory to the existing drugs. Sinomenine has shown neuroprotective effects through counteracting oxidative stress, inflammation and pyroptosis. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101800DOI Listing

Neurologic Manifestations of Severe Respiratory Viral Contagions.

Crit Care Explor 2020 Apr 29;2(4):e0107. Epub 2020 Apr 29.

Both authors: Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL.

Endemic and pandemic viral respiratory infections have recently emerged as a critical topic of investigation given the recent severe acute respiratory syndrome coronavirus-2 outbreak. Data from such outbreaks indicate that severe systemic comorbidities including acute neurologic illness are associated with illness and lead to significant outcome differences. Herein, we will discuss the neurologic manifestations of severe viral respiratory infections including coronavirus, influenza, respiratory syncytial virus, metapneumovirus, and enterovirus. Read More

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http://dx.doi.org/10.1097/CCE.0000000000000107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188429PMC

Iatrogenic humeral anatomic neck fracture after intraosseous vascular access.

Skeletal Radiol 2020 May 18. Epub 2020 May 18.

Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA.

Intraosseous infusion has become a key tool in the resuscitation of critically ill or injured patients, both in pre-hospital settings and in emergency departments. Intraosseous access is obtained through the percutaneous placement of a needle into the medullary space of a bone, thereby allowing access into the systemic venous circulation via the medullary space, which is essential to treat patients in shock, cardiac arrest, airway compromise, or major trauma. This becomes critically important when obtaining conventional intravenous access is difficult or impossible. Read More

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http://dx.doi.org/10.1007/s00256-020-03462-4DOI Listing

Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus.

ASN Neuro 2020 Jan-Dec;12:1759091420926836

Department of Neurology, First Affiliated Hospital, Kunming Medical University.

Nuclear-distribution element-like 1 (NDEL1) is associated with the proliferation and migration of neurons. Vascular endothelial growth factor (VEGF) in combination with VEGF receptor-2 (VEGFR-2) regulates the proliferation and migration of neurons. This study was performed to explore undefined alterations in the expression levels of NDEL1 and VEGF/VEGFR-2 within the hippocampus after status epilepticus (SE). Read More

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http://dx.doi.org/10.1177/1759091420926836DOI Listing

The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus.

Epilepsia 2020 May 18. Epub 2020 May 18.

Department of Experimental and Clinical Pharmacology and Center for Orphan Drug Research, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.

The Established Status Epilepticus Treatment Trial was a blinded, comparative-effectiveness study of fosphenytoin, levetiracetam, and valproic acid in benzodiazepine-refractory status epilepticus. The primary outcome was clinical seizure cessation and increased responsiveness without additional anticonvulsant medications. Weight-based dosing was capped at 75 kg. Read More

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http://dx.doi.org/10.1111/epi.16534DOI Listing

Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats.

Epilepsia 2020 May 18. Epub 2020 May 18.

Department, of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.

Objective: Approximately 30% of patients with epilepsy do not experience full seizure control on their antiseizure drug (ASD) regimen. Historically, screening for novel ASDs has relied on evaluating efficacy following a single administration of a test compound in either acute electrical or chemical seizure induction. However, the use of animal models of spontaneous seizures and repeated administration of test compounds may better differentiate novel compounds. Read More

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http://dx.doi.org/10.1111/epi.16531DOI Listing

Kawasaki disease presented with status epilepticus and diffusion MRI abnormalities in the subcortical white matter.

Turk J Pediatr 2020 ;62(2):315-319

Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

Background: Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and young children. Encephalitis/encephalopathy is an extremely rare complication of KD.

Case: A previously healthy 8-month-old Japanese boy had a prolonged seizure after febrile illness for one day. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.020DOI Listing
January 2020

Treatment of status epilepticus with zonisamide: A multicenter cohort study of 34 patients and review of literature.

Epilepsy Behav 2020 May 14;109:107139. Epub 2020 May 14.

Department of Neurology and Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt and University Hospital Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany; Department of Neurology and Epilepsy Center Hessen, Philipps-University Marburg, Marburg (Lahn), Germany. Electronic address:

Introduction: We present a summary of clinical cases of oral zonisamide (ZNS) used to treat refractory and super-refractory episodes of status epilepticus (SE).

Methods: Zonisamide administration in SE was identified in the clinical records of patients treated in Frankfurt and Marburg between 2011 and 2017.

Results: Zonisamide was administered during a total of 37 SE episodes in 34 patients with a mean age of 58. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107139DOI Listing

Seizures associated with coronavirus infections.

Seizure 2020 May 11;79:49-52. Epub 2020 May 11.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

Neurotropic and neuroinvasive capabilities of coronaviruses have been described in humans. Neurological problems found in patients with coronavirus infection include: febrile seizures, convulsions, loss of consciousness, encephalomyelitis, and encephalitis. Coronavirus disease (COVID-19) is caused by SARS-CoV2. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212943PMC

Status Epilepticus Dynamics Predicts Latency to Spontaneous Seizures in the Kainic Acid Model.

Cell Physiol Biochem 2020 May;54(3):493-507

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy,

Background/aims: Status epilepticus (SE) might be followed by temporal lobe epilepsy (TLE), a common neurologic disorder characterized by spontaneous recurrent seizures (SRSs). However, the relationship between SE and TLE is still incompletely characterized. For this reason, in a model of TLE we evaluated the lesion extent and the onset of SRSs to determine if they were influenced by the SE dynamics. Read More

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http://dx.doi.org/10.33594/000000232DOI Listing

Levetiracetam for Benzodiazepine-Refractory Status Epilepticus.

Indian J Pediatr 2020 May 15. Epub 2020 May 15.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

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http://dx.doi.org/10.1007/s12098-020-03341-9DOI Listing

Tuberculous meningitis presenting with nonconvulsive status epilepticus and transient diffusion restriction: A rare case.

Neurol India 2020 Mar-Apr;68(2):512-514

Department of Neurology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, Japan.

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http://dx.doi.org/10.4103/0028-3886.283759DOI Listing

Fatal metaldehyde poisoning in a dog confirmed by gas chromatography.

BMC Vet Res 2020 May 15;16(1):139. Epub 2020 May 15.

Department of Veterinary Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Background: Metaldehyde is a toxic pesticide used mainly as a molluscicide, responsible for intoxication and deaths in both humans and animals. Accidental exposure to metaldehyde in dogs is considered rare, but severe. Data concerning clinical and veterinary forensic toxicology are largely incomplete, especially regarding case reports in dogs. Read More

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http://dx.doi.org/10.1186/s12917-020-02348-wDOI Listing

Design of composite measure schemes for comparative severity assessment in animal-based neuroscience research: A case study focussed on rat epilepsy models.

PLoS One 2020 15;15(5):e0230141. Epub 2020 May 15.

Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University, Munich, Germany.

Comparative severity assessment of animal models and experimental interventions is of utmost relevance for harm-benefit analysis during ethical evaluation, an animal welfare-based model prioritization as well as the validation of refinement measures. Unfortunately, there is a lack of evidence-based approaches to grade an animal's burden in a sensitive, robust, precise, and objective manner. Particular challenges need to be considered in the context of animal-based neuroscientific research because models of neurological disorders can be characterized by relevant changes in the affective state of an animal. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230141PLOS

Hypothermia as an adjuvant treatment in paediatric refractory or super-refractory status epilepticus.

Authors:
Stephane Legriel

Dev Med Child Neurol 2020 May 15. Epub 2020 May 15.

Medico-Surgical Intensive Care Department, Centre Hospitalier de Versailles, Le Chesnay, France.

Therapeutic hypothermia is among the adjuvant therapies suggested for refractory or super-refractory status epilepticus (R/SR-SE) in paediatric patients. Experimental evidence of neuroprotective and antiseizure effects provides a strong rationale for using therapeutic hypothermia in patients with status epilepticus. Thus, hypothermia between 20°C and 33°C in animals with status epilepticus is associated not only with significantly less neuronal damage, predominantly in the hippocampal CA1, CA2, and CA3 areas, but also with increased seizure latency and decreased seizure frequency and duration. Read More

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http://dx.doi.org/10.1111/dmcn.14562DOI Listing

Investigation of Cerebral O-(2-[F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models.

Mol Imaging Biol 2020 May 14. Epub 2020 May 14.

Institute of Neuroscience and Medicine (INM-4; INM-5; INM-11), Forschungszentrum Jülich, 52425, Jülich, Germany.

Purpose: A recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[F]fluoroethyl)-L-tyrosine ([F]FET) induced by epileptic activity. Therefore, we examined cerebral [F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to further investigate whether this phenomenon represents a major pitfall in brain tumor diagnostics and whether [F]FET may be a potential marker to localize epileptic foci.

Procedures: Five rats underwent kainic acid titration to exhibit 3 to 3. Read More

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http://dx.doi.org/10.1007/s11307-020-01503-xDOI Listing

De Novo Status Epilepticus in patients with COVID-19.

Ann Clin Transl Neurol 2020 May 14. Epub 2020 May 14.

Department of Neurology, University of Alabama at Birmingham, AL, United Kingdom.

Neurological complications are increasingly recognized with SARS CoV-2, the causative pathogen for COVID-19. We present a single-center retrospective case series reporting the EEG and outcome of de novo status epilepticus (SE) in two African-American women with laboratory-confirmed SARS CoV-2 virus. SE was the initial presentation in one asymptomatic individual. Read More

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http://dx.doi.org/10.1002/acn3.51071DOI Listing

Presence of generalized periodic discharges and hospital mortality.

Arq Neuropsiquiatr 2020 May 11. Epub 2020 May 11.

Hospital Universitário Cajuru, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.

Background: Generalized periodic discharges (GPDs) are rare patterns that can be found in long-term electroencephalographic monitoring in critical patients. These patterns have been correlated with non-seizure crisis and non-convulsive status epilepticus, associated with poor prognosis.

Objective: To compare the outcome between patients who developed GPDs and patients with other abnormalities in long-term electroencephalographic monitoring. Read More

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http://dx.doi.org/10.1590/0004-282x20200026DOI Listing

Neurological Emergencies in Patients Hospitalized With Nonneurological Illness.

J Patient Saf 2020 May 7. Epub 2020 May 7.

From the Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine.

Objective: We aimed to present neurological profiles and clinical outcomes of patients with acute neurological symptoms, which developed during hospitalization with nonneurological illness.

Methods: We organized the neurological alert team (NAT), a neurological rapid response team, to manage in-hospital neurological emergencies. In this registry-based study, we analyzed the clinical profiles and outcomes of patients who were consulted to the NAT. Read More

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http://dx.doi.org/10.1097/PTS.0000000000000682DOI Listing

Prognostic Significance of Cyclic Seizures in Status Epilepticus.

J Clin Neurophysiol 2020 May 7. Epub 2020 May 7.

Department of Neurology, New York Presbyterian Queens, Flushing, New York, U.S.A.

Purpose: Status epilepticus (SE) is a commonly encountered neurologic condition associated with high mortality rates. Cyclic seizures (CS) are a common form of SE, but its prognostic significance has not been well established. In this retrospective study, the mortality of cyclic versus noncyclic forms (NCSs) of SE are compared. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000714DOI Listing

Variable treatment response in a patient with pyridoxal phosphate oxidase (PNPO) deficiency- understanding the paradox.

Epilepsy Behav Rep 2020 24;14:100357. Epub 2020 Mar 24.

Department of Paediatrics, Aster Malabar Institute of Medical Sciences, Kozhikode, Kerala, India.

A 6-year-old girl presented with history of infantile onset epileptic encephalopathy and developmental delay. She had polymorphic seizures that were refractory to regular anti-seizure medication. Incomplete control of seizures was achieved on starting pyridoxine, riboflavin and thiamine. Read More

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http://dx.doi.org/10.1016/j.ebr.2020.100357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210397PMC

Intraoperative refractory status epilepticus caused by propofol.

Korean J Anesthesiol 2020 May 11. Epub 2020 May 11.

Additional Professor, Anaesthesiology, AIIMS Patna, India.

Background: Status Epilepticus, when continued despite the administration of two antiepileptic drugs, is called refractory status epilepticus (RSE). The seizure-like phenomenon due to propofol is widely reported in the literature. However, refractory status epilepticus (RSE) caused by propofol is rare and is a diagnostic dilemma. Read More

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http://dx.doi.org/10.4097/kja.20162DOI Listing

Optimizing status epilepticus care during the COVID-19 pandemic.

Epilepsy Behav 2020 Apr 21;109:107124. Epub 2020 Apr 21.

Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.yebeh.2020.107124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172759PMC

Intramuscular Versus Buccal Midazolam for Pediatric Seizures: A Randomized Double-Blinded Trial.

Pediatr Neurol 2020 Mar 16. Epub 2020 Mar 16.

Department of Pediatrics, Division of Pediatric Emergency Medicine, Hamad Medical Corporation, Doha, Qatar.

Background: We compared the efficacy and safety of intramuscular with buccal midazolam as first-line treatment for active seizures in children brought to the emergency department.

Methods: In a double-blind, double-dummy randomized trial, patients with an active seizure lasting more than five minutes received blinded treatments on arrival. We employed deferred consent. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2020.03.011DOI Listing

Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics.

Mol Neurobiol 2020 May 6. Epub 2020 May 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Prolonged status epilepticus (SE) in humans causes high mortality and brain inflammation-associated neuronal injury and morbidity in survivors. Currently, the only effective treatment is to terminate the seizures swiftly to prevent brain damage. However, reliance on acute therapies alone would be imprudent due to the required short response time. Read More

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http://dx.doi.org/10.1007/s12035-020-01923-4DOI Listing

Clinical Features and Evaluation in Terms of Prophylaxis of Patients With Febrile Seizures.

Authors:
Betül Kılıç

Sisli Etfal Hastan Tip Bul 2019 27;53(3):276-283. Epub 2019 Aug 27.

Department of Pediatric Neurology, Health Sciences University Faculty of Medicine, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Objectives: Febrile seizures are the most common seizure type of childhood, and prognosis is usually good. Many factors that increase the risk of recurrence and develop epilepsy have been identified. This study aims to determine the clinical characteristics of patients who were admitted with the febrile seizure, and determine the outcomes of the treatment, and the risk factors. Read More

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http://dx.doi.org/10.14744/SEMB.2019.30633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192276PMC

Sleep slow wave homeostasis and cognitive functioning in children with electrical status epilepticus in sleep.

Sleep 2020 May 6. Epub 2020 May 6.

Division of Clinical Neurophysiology, Department of Neurology, University Children's Hospital Zurich, Zurich, Switzerland.

Study Objectives: Encephalopathy with electrical status epilepticus in sleep (ESES) is characterised by non-rapid eye movement (non-REM)-sleep-induced epileptiform activity and acquired cognitive deficits. The synaptic homeostasis hypothesis describes the process of daytime synaptic potentiation balanced by synaptic downscaling in non-REM-sleep and is considered crucial to retain an efficient cortical network. We aimed to study the overnight decline of slow waves, an indirect marker of synaptic downscaling, in patients with ESES and explore whether altered downscaling relates to neurodevelopmental and behavioural problems. Read More

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http://dx.doi.org/10.1093/sleep/zsaa088DOI Listing

Anti-gamma-aminobutyric acid receptor type A encephalitis: a review.

Curr Opin Neurol 2020 Jun;33(3):372-380

Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

Purpose Of Review: To systematically review the clinical features, diagnosis, and management of anti-gamma-aminobutyric acid receptor Type A (GABAA) autoimmune encephalitis with a focus on recent data.

Recent Findings: In a review of published reports, we identified 50 cases of anti-GABAA receptor encephalitis with clinical features reported. The median age at presentation was 47 years old (range, 2. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000814DOI Listing

Corrigendum to Institutional Factors Contribute to Variation in Intubation Rates in Status Epilepticus.

Authors:

Neurohospitalist 2020 Apr 24;10(2):155. Epub 2020 Jan 24.

[This corrects the article DOI: 10.1177/1941874418819349.]. Read More

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http://dx.doi.org/10.1177/1941874420904792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191671PMC

Sudden Onset Fluent Aphasia: Stroke or Seizure?

Neurohospitalist 2020 Apr 28;10(2):121-126. Epub 2019 Jul 28.

Department of Neurology, Emory University, Atlanta, GA, USA.

Conventional understanding of acute onset language deficits indicates that fluent aphasias are due to perisylvian lesions in the dominant hemisphere, most often in the setting of acute stroke. Case studies and retrospective analyses, however, suggest the need to keep ictal phenomena as an alternative diagnostic possibility. The following case illustrates an epileptic mechanism of sudden onset fluent aphasia mimicking an acute stroke presentation. Read More

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http://dx.doi.org/10.1177/1941874419864757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191664PMC

Gelatinase Biosensor Reports Cellular Remodeling During Epileptogenesis.

Front Synaptic Neurosci 2020 21;12:15. Epub 2020 Apr 21.

IGF, Université de Montpellier, CNRS, INSERM, Montpellier, France.

Epileptogenesis is the gradual process responsible for converting a healthy brain into an epileptic brain. This process can be triggered by a wide range of factors, including brain injury or tumors, infections, and status epilepticus. Epileptogenesis results in aberrant synaptic plasticity, neuroinflammation and seizure-induced cell death. Read More

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http://dx.doi.org/10.3389/fnsyn.2020.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186352PMC

Ketamine-dexmedetomidine combination and controlled mild hypothermia for the treatment of long-lasting and super-refractory status epilepticus in 3 dogs suffering from idiopathic epilepsy.

J Vet Emerg Crit Care (San Antonio) 2020 May 6. Epub 2020 May 6.

Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.

Objective: To describe the use of a ketamine-dexmedetomidine combination and mild hypothermia for the treatment of status epilepticus in 3 dogs that did not respond to GABAergic medication.

Case Series Summary: Three dogs, each with a diagnosis of idiopathic epilepsy, were presented to the emergency department in a state of status epilepticus. The dogs were treated unsuccessfully with benzodiazepine as a first-line therapy that was followed by IV propofol anesthesia maintained for at least 12 hours. Read More

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http://dx.doi.org/10.1111/vec.12956DOI Listing

New-onset refractory status epilepticus and febrile infection-related epilepsy syndrome.

Dev Med Child Neurol 2020 May 5. Epub 2020 May 5.

Rare and Complex Epilepsy Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children Hospital, Rome, Italy.

New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES) are relatively rare clinical presentations. They are characterized by de novo onset of refractory status epilepticus (RSE) without clearly identifiable acute or active cause (structural, toxic, or metabolic). We reviewed the literature using PubMed reports published between 2003 and 2019 and summarized the clinical, neurophysiological, imaging, and treatment findings. Read More

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http://dx.doi.org/10.1111/dmcn.14553DOI Listing