973,996 results match your criteria Status Epilepticus


Fms-like tyrosine kinase 3 is a key factor of male fertility.

Theriogenology 2018 Dec 8;126:145-152. Epub 2018 Dec 8.

Department of Animal Science & Technology, Chung-Ang University, Anseong, Gyeonggi-Do, 17546, Republic of Korea. Electronic address:

Fms-like tyrosine kinase 3 (FLT3) is a type III kinase that is highly expressed in seminal plasma of infertile men. FLT3 activation can be blocked by inhibition of its phosphorylation using the nontoxic and selective inhibitor, quizartinib. We investigated the function of FLT3 and the corresponding effects of quizartinib in mouse spermatozoa. Read More

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December 2018
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Concentrations, speciation, and ecological risk of heavy metals in the sediment of the Songhua River in an urban area with petrochemical industries.

Chemosphere 2018 Dec 10;219:538-545. Epub 2018 Dec 10.

Jilin Institute of Chemical Technology, Jilin, 132022, China. Electronic address:

In this study, the pollution status and the ecological risks of heavy metals (Cu, Zn, Pb, Ni and Cr) in the sediments of the Songhua River in an urban area with petrochemical industries were assessed. The highest mean concentration of total heavy metals occurred in the freezing period, and the highest total heavy metal concentrations were observed near the petrochemical industrial area. The geo-accumulation index indicated that Cu was the most contaminated heavy metal. Read More

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December 2018

Prevalence and clinical correlations of obsessive-compulsive symptoms in schizophrenia.

Asian J Psychiatr 2018 Nov 27;39:48-52. Epub 2018 Nov 27.

Department of Psychiatry, Centre of Excellence in Mental Health, PGIMER Dr RML Hospital, New Delhi, India. Electronic address:

Introduction: Obsessive compulsive symptoms are often present in persons with schizophrenia. Adequately powered studies to evaluate the effect of such symptoms in the course of the disorder, are few.

Aim: We aimed to estimate the prevalence and type of obsessive-compulsive symptoms in persons with schizophrenia. Read More

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November 2018

Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis.

Environ Int 2018 Dec 12;123:301-309. Epub 2018 Dec 12.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. Read More

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December 2018

Networks of problems: social, psychological, and genetic influences on health.

Curr Opin Psychol 2018 Nov 30;27:88-92. Epub 2018 Nov 30.

Department of Sociology, Stanford University, United States.

An emerging idea in psychopathology conceives of disorders as networks of mutually-reinforcing symptoms that constitute the disorder rather than simply reflect it. This is similar to how social scientists already view socioeconomic status, and has affinities to how physical health problems compound in later life. Social, psychological, and physical conditions might therefore be thought of as networks of problems with 'causal bridges' that span different levels and bring low SES, mental health challenges, and physical health problems into pervasive relationships with one another. Read More

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November 2018
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Clinicopathological characteristics of metaplastic breast cancer - analysis of the basic immunohistochemical profile and comparison with other invasive breast cancer types.

Breast 2018 Dec 7;43:135-141. Epub 2018 Dec 7.

Department of Biophysics and Human Physiology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.

Introduction: Metaplastic breast cancer (MpBC) is a rare but aggressive type of breast cancer accounting for 0.25-1% of all diagnosed invasive breast cancers. Morphologically, it is characterized by differentiation of the neoplastic epithelium into squamous cells and/or mesenchymal-looking tissue. Read More

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December 2018

A comparison between physical and biopsychosocial measures of frailty: Prevalence and associated factors in Brazilian older adults.

Arch Gerontol Geriatr 2018 Dec 6;81:111-118. Epub 2018 Dec 6.

National School of Public Health/Oswaldo Cruz Foundation, Department of Epidemiology and Quantitative Methods, Rua Leopoldo Bulhões, 1480/room 817b, Manguinhos, 21041-210 Rio de Janeiro, RJ, Brazil. Electronic address:

Purpose: To estimate the prevalence of frailty, according to Tilburg Frailty Indicator (TFI) and CHS index, to investigate the correlation between both instruments and to identify the factors associated with this condition in older users of primary health care.

Methods: This is a sectional study with 302 individuals aged 60 years or more of Rio de Janeiro/Brazil. Sociodemographic, health, functional dependence and lifestyle variables were collected. Read More

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December 2018

Development and validation of a brief electronic screening test for cognitive impairment in multiple sclerosis (SCI-MS Test).

Mult Scler Relat Disord 2018 Dec 3;28:50-56. Epub 2018 Dec 3.

Department of Neurology, Clinical Neuroimmunology and Multiple Sclerosis Unit, "Donostia" Universitary Hospital, San Sebastian, Spain.

Objective: Although cognitive impairment (CI) is common in multiple sclerosis (MS), it is difficult to suspect in patients with low disability and there is a lack of brief and effective CI screening tools with a define cut-off point to be used during routine clinic visits. This study aims to validate the Electronic Screening Cognitive Impairment in Multiple Sclerosis (SCI-MS) test for CI among MS patients.

Methods: Cross-sectional, observational study that included adult patients, diagnosed with MS, Expanded Disability Status Scale (EDSS) score ≤6. Read More

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December 2018

Autoimmune encephalitis following alemtuzumab treatment of multiple sclerosis.

Mult Scler Relat Disord 2018 Dec 3;28:31-33. Epub 2018 Dec 3.

Department of Neurology, St Vincent's Hospital, 390 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia.

Secondary autoimmune disorders are a recognised complication of alemtuzumab treatment for multiple sclerosis. We report a case of autoimmune encephalitis manifesting as a polymorphic epilepsia partialis continua / status epilepticus seven months after the second course of alemtuzumab in a patient with previous autoimmune hypothyroidism and immune thrombocytopenic purpura. An MRI revealed multifocal cortical abnormalities and neuronal loss was evident on biopsy. Read More

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December 2018
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Relationship between anxiety, depression, sex, obesity, and internet addiction in Chinese adolescents: A short-term longitudinal study.

Addict Behav 2018 Dec 7;90:421-427. Epub 2018 Dec 7.

Research Institute on Addictions, University at Buffalo, State University of New York, Buffalo, NY, United States. Electronic address:

Associations between anxiety, depression and adolescent Internet addiction have been well documented in the literature; however, few published studies have examined these relationships considering the developmental trajectory courses of adolescent Internet addiction as well as the individual differences over time. Using a sample of 1545 Chinese adolescents and 3 waves of data over six months, we examined the longitudinal associations between anxiety and depression and Internet addiction, considering sex and obesity. We used latent growth curve modeling (LGCM) to examine the overall conditions of Internet addiction, and latent class growth modeling (LCGM) to determine adolescent developmental membership for Internet addiction. Read More

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December 2018

Influence of hypertension on brain amyloid deposition and Alzheimer's disease signature neurodegeneration.

Neurobiol Aging 2018 Nov 16;75:62-70. Epub 2018 Nov 16.

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

This study aimed to investigate the relationship of hypertension with beta-amyloid (Aβ) and neurodegeneration biomarkers of Alzheimer's disease (AD) and the modulating effect of apolipoprotein E-ε4 (APOE4). In total, 259 cognitively normal (CN) and 79 AD dementia older adults received clinical assessments including the evaluation for the presence of hypertension, [C]-Pittsburgh-compound-B-positron emission tomography, magnetic resonance imaging, and APOE genotyping. We used a clinical stage-specific approach, separately focusing on CN and AD dementia stages. Read More

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November 2018

Interaction of hormonal and social environments in understanding body image concerns in adolescent girls.

J Psychiatr Res 2018 Dec 7;109:178-184. Epub 2018 Dec 7.

Department of Psychology, Michigan State University, 316 Physics Rd #262, East Lansing, MI, 48824, USA.

During adolescence, peer approval becomes increasingly important and may be perceived as contingent upon appearance in girls. Concurrently, girls experience hormonal changes, including an increase in progesterone. Progesterone has been implicated in affiliative behavior but inconsistently associated with body image concerns. Read More

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December 2018

The association between the longitudinal course of common mental disorders and subsequent physical activity status in young adults: A 30-year birth cohort study.

J Psychiatr Res 2018 Dec 6;109:173-177. Epub 2018 Dec 6.

Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia; School of Public Health, The University of Queensland, Herston, Australia; Metro North Mental Health, Royal Brisbane and Women's Hospital, Herston, Australia.

Low physical activity is a major public health concern. There has been extensive research examining the role of physical activity as a potentially modifiable risk factor for the onset of mental illness. However, fewer studies have reported how mental disorders affect future physical activity. Read More

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December 2018
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Excess copper promotes photoinhibition and modulates the expression of antioxidant-related genes in Zostera muelleri.

Aquat Toxicol 2018 Dec 5;207:91-100. Epub 2018 Dec 5.

Climate Change Cluster, University of Technology Sydney, NSW, Australia.

Copper (Cu) is an essential micronutrient for plants and as such is vital to many metabolic processes. Nevertheless, when present at elevated concentrations, Cu can exert toxic effects on plants by disrupting protein functions and promoting oxidative stress. Due to their proximity to the urbanised estuaries, seagrasses are vulnerable to chemical contamination via industrial runoff, waste discharges and leachates. Read More

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December 2018

Cladophora glomerata methanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs).

Biomed Pharmacother 2018 Dec 12;111:6-18. Epub 2018 Dec 12.

Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375 Wrocław, Poland; Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392 Gießen, Germany. Electronic address:

Reactive oxygen species (ROS) are key mediators of several cellular damage and thus associated with equine diseases such as inflammation and metabolic syndrome. This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by HO. Read More

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December 2018

Predictors of self-harm emergency department visits in adolescents: A statewide longitudinal study.

Gen Hosp Psychiatry 2018 Dec 8;56:28-35. Epub 2018 Dec 8.

Violence Prevention Research Program, University of California, Davis, Sacramento, CA 95817, USA. Electronic address:

Objective: This study investigated patient- and area-level characteristics associated with adolescent emergency department (ED) patients' risk of subsequent ED visits for self-harm.

Method: Retrospective analysis of adolescent patients presenting to a California ED in 2010 (n = 480,706) was conducted using statewide, all-payer, individually linkable administrative data. We examined associations between multiple predictors of interest (patient sociodemographic factors, prior ED utilization, and residential mobility; and area-level characteristics) and odds of a self-harm ED visit in 2010. Read More

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December 2018

Efficacy and safety of partial splenic embolization for hypersplenism in pre- and post-liver transplant patients: A 16-year comparative analysis.

Clin Imaging 2018 Nov 27;54:71-77. Epub 2018 Nov 27.

Department of Radiology, Division of Vascular and Interventional Radiology, Columbia University Medical Center, 177 Fort Washington Ave, Milstein Hospital - 4 Hudson North, New York, NY 10032, United States of America.

Purpose: To report the effect of partial splenic embolization (PSE) on hematological indices and the procedure's safety in pre- and post-liver transplant (LT) patients.

Materials And Methods: A single-center retrospective study evaluating all patients who underwent PSE over a 16-year period was performed. Inclusion criteria were splenomegaly confirmed by imaging and at least one of the following cytopenias: hemoglobin ≤10 g/dL, WBC count ≤1500 μL, or platelet count ≤100,000 μL. Read More

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November 2018
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Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism.

J Nutr Biochem 2018 Nov 10;64:206-217. Epub 2018 Nov 10.

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Normally, the gut microbiota has a mutually beneficial association with host health and maintains its commensal status in mammals. Conversely, it can also negatively influence host physiology under some certain circumstances, including obesity and other disease states. Although numerous gut microbial functions directly affect the gastrointestinal tract, in this paper, we focus on the influences of the gut microbiota on host adipose tissue and energy metabolism, particularly lipometabolism. Read More

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November 2018
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Ultra-short burst suppression as a "reset switch" for refractory status epilepticus.

Seizure 2018 Dec 5;64:41-44. Epub 2018 Dec 5.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, United States. Electronic address:

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December 2018

Maternal childhood emotional abuse predicts Chinese infant behavior problems: Examining mediating and moderating processes.

Child Abuse Negl 2018 Dec 12;88:307-316. Epub 2018 Dec 12.

Beijing Key Laboratory of Learning and Cognition, Research Center for Child Development, School of Psychology, Capital Normal University, China.

The current study examined the mediating effect of maternal negative expressiveness as well as the moderating effects of infant inhibitory control (IC) in the association between maternal childhood emotional abuse (CEA) and infant behavior problems. Drawing from 207 families from mainland China, 2-wave data were reported in this study when the infants were 6 months (T1) and 14 (T2) months. Mothers (Mean age = 32. Read More

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December 2018

Are parents at a higher risk for secondary traumatic stress?: How interviewing child victims impacts relationships with forensic interviewer's friends and family.

Child Abuse Negl 2018 Dec 12;88:275-287. Epub 2018 Dec 12.

School of Arts & Sciences, University of Houston-Victoria, 3007 N. Ben Wilson, Victoria, TX, 77904, United States. Electronic address:

Background: Forensic interviewers are at a heightened risk for secondary traumatic stress (STS) due to their frequent interactions with victims of child maltreatment (Bonach & Heckert, 2012). To date, however, few studies have examined the negative effects of this work on interviewers' social and emotional well-being.

Objective: The present study seeks to explore the effect of STS on the relationships of forensic interviewers, including those with friends, family, and their respective children. Read More

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December 2018

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology and Biotechnology "Charles Darwin", La Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.; Pasteur Institute-Cenci Bolognetti Foundation, Viale Regina Elena, 291, 00100 Rome, Italy.. Electronic address:

Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle interactions, we discovered that Erg27p resides mainly in Lipid Droplets (LDs) in respiratory competent cells, while in absence of respiration, is found mostly in the ER. Read More

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December 2018

Higher sleep spindle activity is associated with fewer false memories in adolescent girls.

Neurobiol Learn Mem 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Background: Sleep facilitates the extraction of semantic regularities amongst newly encoded memories, which may also lead to increased false memories. We investigated sleep stage proportions and sleep spindles in the recollection of adolescents' false memories, and their potential sex-specific differences.

Methods: 196 adolescents (mean age 16. Read More

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December 2018

Mechanisms of Pyrethroid Resistance in Aedes (Stegomyia) aegypti from Colombia.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Centro Internacional de Entrenamiento e Investigaciones Médicas CIDEIM, Carrera 125 N 19-225, Cali, Colombia; Universidad ICESI, Cali,Colombia. Electronic address:

In Colombia Aedes (Stegomyia) aegypti is the main vector of urban arboviruses such as dengue, chikungunya and Zika. This urban mosquito has a well-established capacity to develop insecticide resistance to different types of insecticides (pyrethroids, organochlorides, organophosphates), using multiple resistance mechanisms. An understanding of ongoing resistance mechanisms is critical to determining the activities of vector control programs. Read More

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December 2018

Ki-67 labeling index in glioblastoma; does it really matter?

Hematol Oncol Stem Cell Ther 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Objective/background: Glioblastoma (GB) is the most common primary malignant brain tumor in adults. Ki-67 is a nonhistone nuclear protein that is expressed by cells entering the mitotic cycle and is associated with the transcription of ribosomal RNA (rRNA). In gliomas, the extent of expression of Ki-67 is roughly proportional to the histologic grade. Read More

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December 2018

Young Cohorts of Russians Drink Less: Age-Period-Cohort Modelling of Alcohol Use Prevalence 1994-2016.

Addiction 2018 Dec 15. Epub 2018 Dec 15.

Laboratory for Studies in Economic Sociology, National Research University Higher School of Economics, 11 Myasnitskaya, Moscow, 101000, Russian Federation.

Background and aims Young Russians have been drinking less alcohol, and less strong spirits in particular, in recent years. This study aimed to disentangle age, period and birth cohort effects for the first time in Russia to improve our understanding of these trends. Design Age, period and cohort analysis of annual nationally representative repeated cross-sectional surveys (RLMS-HSE) using separate logistic models for each gender. Read More

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December 2018

Prospective instrumental evaluation of swallowing, tongue function, and QOL measures following transoral robotic surgery alone without adjuvant therapy.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

THANC Foundation, New York, New York.

Background: Transoral robotic surgery (TORS) has been utilized to deintensify treatment. No studies have measured swallow safety and efficiency, nor assessed the functional impact of TORS alone.

Methods: This prospective cohort underwent baseline and 1-month postsurgery assessments including modified barium swallow evaluation, using the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) rating system, tongue range of motion assessment, the Performance Status Scale (PSS), and quality of life with the MD Anderson Dysphagia Inventory (MDADI). Read More

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December 2018

Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after radical surgery: A large-scale prospective study.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.

Background: To develop and validate practical prognostic indexes (PIs) for predicting the prognosis and response to postoperative adjuvant therapy in patients with oral squamous cell carcinoma (OSCC).

Methods: A large cohort of 1071 OSCC patients were randomized to either training set (N = 708) or validation set (N = 363). Three types of PIs were developed according to the nomogram scores, β coefficients and excess hazard ratios, respectively. Read More

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December 2018
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Masticatory function and related factors after oral oncological treatment: a 5-year prospective study.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Oral and Maxillofacial Surgery and Special Dental Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Chewing ability is often compromised in patients with oral cancer. The aim of this study was to identify which factors affect masticatory performance in these patients.

Methods: Patients with primary oral cancer were assessed for up to 5 years after primary treatment. Read More

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December 2018

Sexual dysfunction factors in patients with schizophrenia treated with second generation antipsychotics: not only prolactin.

Actas Esp Psiquiatr 2018 Nov 1;46(6):217-25. Epub 2018 Nov 1.

Unidad de Gestión Clínica de Salud Mental. Hospital Universitario de Valme. Sevilla. España.

Introduction: Despite the high prevalence of sexual dysfunction in patients with schizophrenia, its origins are still unclear.

The Aim Of This Study: to determine the prevalence and causal factors of sexual dysfunction in a group of outpatients with schizophrenia.

Methods: The study was designed to be cross-sectional and naturalistic, including outpatients with schizophrenia undergoing second generation antipsychotic monotherapy. Read More

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November 2018

Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tuebingen, Germany.

Aim: Pharmacologic administration of insulin as nasal spray in humans has demonstrated a modulation of endogenous glucose production via the brain when systemic insulin levels are high. Results are conflicting under fasting insulin concentrations. To evaluate effects of brain insulin on endogenous glucose production in fasting humans with focus on hepatic glucose release, we performed a randomized, placebo controlled, blinded, cross-over experiment. Read More

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December 2018
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Newly-graduated nurses' experiences of a trainee programme regarding the introduction process and leadership in a hospital setting - a qualitative interview study.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

Sophiahemmet University, Box 5605, SE-114 86, Stockholm, Sweden.

Aim And Objectives: This study aimed to describe newly-graduated nurses' experiences of introduction processes and leadership within a hospital trainee programme.

Background: For many, being a newly-graduated nurse is associated with stress, influenced by the challenge of the transition to independent nurse, coupled with the loss of mentorship due to nurse turnover and rapidly changing demands.

Methods: A qualitative design with an inductive approach was chosen and four focus groups were convened. Read More

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December 2018

A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer.

Cancer Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

Background: Prognosis among patients with differentiated thyroid cancer is widely variable. Better understanding of biologic subtypes is necessary to stratify patients and improve outcomes.

Methods: In patients diagnosed with classic histology papillary thyroid cancer treated from 1973 to 2009, BRAF V600E mutation status was determined on surgical tumor specimens by restriction fragment length polymorphism analysis. Read More

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December 2018

Undocumented migrants' life situations: an exploratory analysis of quality of life and living conditions in a sample of undocumented migrants living in Norway.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Oslo Metropolitan University.

Aims And Objectives: To gather insight in conditions important to an understanding of undocumented migrants' life situations and more specifically to explore undocumented migrants' quality of life and how we can understand the various domains of quality of life related to demographics, living conditions, migration history and inflicted burden.

Background: Undocumented migrants suffer from economic hardship and acculturative stress, limited psychological and social support and at the same time restricted access to health care and social welfare.

Design: An exploratory mixed methods design using primarily quantitative data with a qualitative component was implemented. Read More

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December 2018

Fastigial nucleus stimulation ameliorates cognitive impairment via modulating autophagy and inflammasomes activation in a rat model of vascular dementia.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, The First Affiliated Hospital to Jinzhou Medical University, Jinzhou, China.

Background: It has been reported that the fastigial nucleus (FSN) plays an important role in the development of vascular dementia (VD). Both autophagy and inflammation are functionally involved in the pathogenesis of VD. In this study, we aimed to evaluate the therapeutic effect of electrical cerebellar fastigial nucleus stimulation (FNS) in VD treatment, as well as the effect of FNS on autophagy and inflammation. Read More

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December 2018
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RS7435335 located in the UGT2B7 gene may be a possible genetic marker for the clinical response and prognosis of breast cancer patients receiving neoadjuvant chemotherapy.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Nursing, Rizhao LanShan of People's Hospital, Rizhao, Shandong, China.

Objective: To evaluate the predictive efficacy and prognostic value of rs7435335 located in the UGT2B7 gene as a genetic marker in breast cancer patients receiving neoadjuvant chemotherapy (NAC).

Methods: A total of 190 patients with breast cancer treated with NAC were enrolled to detect the rs7435335 SNP by sequenom. Miller-Payne grades were used to evaluate the treatment efficacy. Read More

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December 2018

HBcAg-induced up-regulated 4-1BB ligand on B cells contributes to B cell hyperactivation during chronic hepatitis B infection.

J Med Virol 2018 Dec 14. Epub 2018 Dec 14.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

During the natural history of chronic hepatitis B infection (CHB) the function of B cells is still obscure. Several limited studies have suggested that B cells are highly active in CHB patients. In present work, we reported that the 4-1BB ligand (4-1BBL) expression on B cells was significantly higher in CHB patients than that in healthy subjects, meanwhile the CHB patients had higher serological IgG levels. Read More

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December 2018
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Lichen planus: altered AIM2 and NLRP1 expression in skin lesions and defective activation in peripheral blood mononuclear cells.

Clin Exp Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Investigation in Medicine, LIM-56, Department of Dermatology, Tropical Medicine Institute of São Paulo, University of São Paulo Medical School, São Paulo, Brazil.

Background: Lichen planus (LP) is an inflammatory skin disease with unknown aetiology. Activation by pathogen-associated molecular patterns or environmental stimuli may activate some components of inflammasomes that contribute to the inflammatory process in LP lesions.

Aim: To characterize the inflammasomes in skin lesions and peripheral blood mononuclear cells (PBMCs) of patients with LP under Toll-like receptor (TLR) activation. Read More

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December 2018
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Hereditary breast cancer; Genetic penetrance and current status with BRCA.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, Menzies Health Institute Queensland, Gold Coast, QLD.

The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. Many BC susceptibility genes can be grouped into two classes, high- and low-penetrance genes, each of which interact with multiple genes and environmental factors. However, the penetrance of genes can also be represented by a spectrum, which ranges between high and low. Read More

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December 2018

Alternative transcript imbalance underlying breast cancer susceptibility in a family carrying PALB2 c.3201+5G>T.

Breast Cancer Res Treat 2018 Dec 14. Epub 2018 Dec 14.

Oncogenetics Group, Vall d'Hebron Institute of Oncology, VHIO, 08035, Barcelona, Spain.

Purpose: Disruption of splicing motifs by genetic variants can affect the correct generation of mature mRNA molecules leading to aberrant transcripts. In some cases, variants may alter the physiological transcription profile composed of several transcripts, and an accurate in vitro evaluation is crucial to establish their pathogenicity. In this study, we have characterized a novel PALB2 variant c. Read More

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December 2018

Polymorphisms in XPC gene and risk for prostate cancer.

Mol Biol Rep 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Protein Engineering and Bio-active Molecules, National Institute of Applied Science and Technology - University of Carthage, Tunis, Tunisia.

Single nucleotide polymorphisms (SNP) in repair gene DNA such as XPC gene can reduce the DNA repair capacity (DRC). Reduced DRC induce genetic instability and may increase the susceptibility to prostate cancer (PC). We conducted a case-controls study to examine the relationship between XPC Lys939Gln and XPC-PAT polymorphisms and the risk for prostate cancer in Tunisian population. Read More

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December 2018
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Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, 130021, China.

Homeostasis imbalance of selenium (Se) in diabetes has received great attention. This study investigated serum and urinary Se levels in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 1 diabetes (T1D), and type 2 diabetes (T2D) in Northeast Chinese populations. From January 2010 to October 2011, patients with IFG (n = 12), IGT (n = 15), T1D (n = 25), T2D (n = 137), and healthy controls (n = 50) were enrolled in the First Hospital of Jilin University. Read More

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December 2018

Gender Stereotypes and Preconception Health: Men's and Women's Expectations of Responsibility and Intentions to Engage in Preventive Behaviors.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Communication, University of Illinois at Urbana-Champaign, Urbana, USA.

Introduction As mounting evidence underscores the importance of both men and women taking steps before pregnancy to improve reproductive outcomes, public health priorities are shifting toward a more gender-inclusive program of promoting preconception health (PCH). This study examined whether prescriptive gender stereotypes, defined as men's and women's beliefs about PCH behavioral norms each gender should uphold, were positively associated with intentions to engage in behaviors to protect a future child's health. Methods Data came from a June 2017 online survey of 609 U. Read More

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December 2018
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Foraging Performance, Prosociality, and Kin Presence Do Not Predict Lifetime Reproductive Success in Batek Hunter-Gatherers.

Hum Nat 2018 Dec 14. Epub 2018 Dec 14.

Department of Anthropology, Dartmouth College, Hanover, NH, 03755, USA.

Identifying the determinants of reproductive success in small-scale societies is critical for understanding how natural selection has shaped human evolution and behavior. The available evidence suggests that status-accruing behaviors such as hunting and prosociality are pathways to reproductive success, but social egalitarianism may diminish this pathway. Here we introduce a mixed longitudinal/cross-sectional dataset based on 45 years of research with the Batek, a population of egalitarian rain forest hunter-gatherers in Peninsular Malaysia, and use it to test the effects of four predictors of lifetime reproductive success: (i) foraging return rate, (ii) sharing proclivity, (iii) cooperative foraging tendency, and (iv) kin presence. Read More

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December 2018

Enhancing coping skills for persons with cancer utilizing mastery enhancement: a pilot randomized clinical trial.

J Behav Med 2018 Dec 14. Epub 2018 Dec 14.

University of Notre Dame, Notre Dame, IN, 46556, USA.

The purpose of this project was to develop a short-term, theory-based intervention for patients with self-reported limited self-efficacy to perform coping behaviors. Cancer patients with low coping self-efficacy were randomly assigned to a treatment (N = 66) or control condition (N = 68). The treatment, Mastery Enhancement Therapy, was based on self-regulation and self-efficacy theories. Read More

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December 2018

Longitudinal airway remodeling in active and past smokers in a lung cancer screening population.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Objectives: To longitudinally investigate smoking cessation-related changes of quantitative computed tomography (QCT)-based airway metrics in a group of heavy smokers.

Methods: CT scans were acquired in a lung cancer screening population over 4 years at 12-month intervals in 284 long-term ex-smokers (ES), 405 continuously active smokers (CS), and 31 subjects who quitted smoking within 2 years after baseline CT (recent quitters, RQ). Total diameter (TD), lumen area (LA), and wall percentage (WP) of 1st-8th generation airways were computed using airway analysis software. Read More

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December 2018

Non-traumatic spinal cord injury in Norway 2012-2016: analysis from a national registry and comparison with traumatic spinal cord injury.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Study Design: Registry-based cross-sectional study.

Objectives: To describe and analyze epidemiological and demographic characteristics of non-traumatic spinal cord injury (NTSCI) and to compare persons with NTSCI and traumatic spinal cord injury (TSCI).

Setting: A total of 225 non-traumatic and 349 traumatic SCI patients were admitted for primary rehabilitation at one of the three specialized SCI departments in Norway (located in Bergen, Trondheim, and Oslo) from 2012 to 2016. Read More

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December 2018

Gender-specific discrepancy in subjective global assessment for mortality in hemodialysis patients.

Sci Rep 2018 Dec 14;8(1):17846. Epub 2018 Dec 14.

Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.

Although subjective global assessment (SGA) is a widely used representative tool for nutritional investigations even among dialysis patients, no studies have examined gender-specific differences in the ability of SGA to predict mortality in hemodialysis (HD) patients. A total of 2,798 dialysis patients were enrolled from clinical research center for end-stage renal disease (CRC for ESRD) between 2009 and 2015. The cohort was divided into two groups based on nutritional status as evaluated by SGA: 'good nutrition' and 'mild to severe malnutrition'. Read More

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December 2018
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Variable gender-dependent platelet responses to combined antiplatelet therapy in patients with stable coronary-artery disease.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Laboratory Diagnostics, Pomeranian Medical University, Szczecin, Poland.

Antiplatelet therapy is considered as a standard procedure against atherosclerotic cardiovscular disease but this therapy has limited effect if resistance to acetylsalicylic acid or clopidogrel is present. Important factors associated with resistance are gender; or inflammation possibly associated with membrane microparticles (MP). It was decided to challenge the hypothesis that differential responses to dual antiplatelet therapy are conditioned by gender and/or proinflammatory status. Read More

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Intravenously Administered Ganaxolone Blocks Diazepam- Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats. Comparison with Allopregnanolone.

J Pharmacol Exp Ther 2018 Dec 14. Epub 2018 Dec 14.

University of Washington School of Pharmacy.

Ganaxolone (GNX) is the 3β-methylated synthetic analog of the naturally occurring neurosteroid, allopregnanolone (ALLO). GNX is effective in a broad range of epilepsy and behavioral animal models and is currently in clinical trials designed to assess its anticonvulsant and antidepressant activities. The current studies were designed to broaden the anticonvulsant profile of GNX by evaluating its potential anticonvulsant activities following intravenous (IV) administration in treatment resistant models of status epilepticus (SE), to establish a pharmacokinetic (PK)/pharmacodynamics (PD) relationship, and to compare its PK and anticonvulsant activities to ALLO. Read More

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December 2018
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