12,672 results match your criteria Status Epilepticus


Quality of life and correlating factors in children, adolescents with epilepsy, and their caregivers: A cross-sectional multicenter study from Germany.

Seizure 2019 Mar 29;69:92-98. Epub 2019 Mar 29.

Epilepsy Center Hessen and Department of Neurology, Philipps-University Marburg, Marburg (Lahn), Germany; Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany. Electronic address:

Purpose: To identify factors correlating with poorer quality of life (QoL) in children and adolescents with epilepsy and regarding QoL and depression of their caregivers in Germany.

Method: A cross-sectional multicenter study on QoL and depression was performed in two representative German states (Hessen and Schleswig-Holstein). Variance analysis, linear regression, and bivariate correlation were used to identify correlating factors for poorer QoL and symptoms of depression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183052
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http://dx.doi.org/10.1016/j.seizure.2019.03.016DOI Listing
March 2019
1 Read

Murine typhus Presenting with Status Epilepticus.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of General Medicine, Changi General Hospital, 2 Simei Street 3, 529889 Singapore.

Patients with rickettsial infection usually present with a febrile illness, headache, arthromyalgia and various biochemical abnormalities. Neurologic involvement is rare in murine typhus. Here, we report a case of a patient who presented with status epilepticus secondary to Rickettsia typhi infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193018
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http://dx.doi.org/10.1016/j.ijid.2019.04.012DOI Listing
April 2019
1 Read

A case of epilepsia partialis continua of abdominal muscles after brain tumor surgery.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3001-3004

IRCCS "NEUROMED", Pozzilli (IS), Italy.

Epilepsia partialis continua (EPC) is a rare form of focal motor status epilepticus characterized by continuous muscular twitches or jerks involving a limited part of the body, usually facial region and distal limb. Although the cerebrovascular disease is known to be one of the most common causes of this condition, other reported cases with predominant abdominal involvement have different aetiologies, including, tumors, focal cortical dysplasia, and central nervous system infections. No cases of epilepsia partialis continua of the abdominal wall occurred after brain surgery have been previously reported. Read More

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http://www.europeanreview.org/article/17581
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http://dx.doi.org/10.26355/eurrev_201904_17581DOI Listing
April 2019
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Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.

Ann Intensive Care 2019 Apr 16;9(1):47. Epub 2019 Apr 16.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.

The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current standards for the clinical assessment of altered consciousness states (including coma and delirium) and peripheral nervous system in critically ill patients, monitoring of brain function (specifically, electro-encephalography) and best practices for sedation-analgesia-delirium management. An update on the treatment of specific severe brain pathologies-including ischaemic/haemorrhagic stroke, cerebral venous thrombosis, hypoxic-ischaemic brain injury, immune-mediated and infectious encephalitis and refractory status epilepticus-was also provided. Read More

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http://dx.doi.org/10.1186/s13613-019-0523-xDOI Listing
April 2019
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Changes to Gamma-Aminobutyric Acid Levels during Short-Term Epileptiform Activity in a Kainic Acid-Induced Rat Model of Status Epilepticus: A Chemical Exchange Saturation Transfer Imaging Study.

Brain Res 2019 Apr 13. Epub 2019 Apr 13.

MR Core Laboratory, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea; Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: To evaluate temporal changes in gamma-aminobutyric acid (GABA) signals in the hippocampus during epileptiform activity induced by kainic acid (KA) in a rat model of status epilepticus using chemical exchange saturation transfer (CEST) imaging technique.

Methods: CEST imaging and H magnetic resonance spectroscopy (H MRS) were applied to a systemic KA-induced rat model to compare GABA signals. All data acquisition and analytical procedures were performed at three different time points (before KA injection, and 1 and 3 hours after injection). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.010DOI Listing

High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

Mini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University, West 5(th) Road, Xincheng District, Xi'an, 710003, PR China. Electronic address:

It has been generally accepted that inflammatory responses induced by status epilepticus (SE) in the brain are associated with microglial activation. One important regulator of microglial activation is high mobility group box-1 (HMGB1) protein. HMGB1 exerts its influence on microglia via various pathways including Toll-like receptor (TLR) subtypes 2 and 4. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193020
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http://dx.doi.org/10.1016/j.brainres.2019.04.007DOI Listing
April 2019
4 Reads
2.843 Impact Factor

The Clinical Spectrum of New-Onset Status Epilepticus.

Crit Care Med 2019 Apr 5. Epub 2019 Apr 5.

All authors: Department of Neurology, Mayo Clinic, Rochester, MN.

Objectives: There is a paucity of data on patients with new-onset status epilepticus in patients without a prior history of epilepsy; we aimed to describe clinical characteristics and assess variables predictive of outcomes.

Design: Retrospective cohort.

Setting: Quaternary academic medical center. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003776DOI Listing

The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats.

Front Cell Neurosci 2019 29;13:123. Epub 2019 Mar 29.

Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai, China.

Cognitive dysfunction is one of the serious complications induced by status epilepticus (SE), which has a significant negative impact on patients' quality of life. Previous studies demonstrated that the pathophysiological changes after SE such as oxidative stress, inflammatory reaction contribute to neuronal damage. A recent study indicated that preventive astaxanthin (AST) alleviated epilepsy-induced oxidative stress and neuronal apoptosis in the brain. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00123
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http://dx.doi.org/10.3389/fncel.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449650PMC
March 2019
2 Reads

Impact of intracranial hypertension on the short-term prognosis in dogs undergoing brain tumor surgery.

J Vet Med Sci 2019 Apr 12. Epub 2019 Apr 12.

Veterinary Anesthesiology & Respiratory Research Laboratory, Department of Veterinary Medicine, Nihon University.

The present study used data from anesthetic records to analyze variables of intracranial pressure (ICP) during brain tumor surgery or in the early postoperative period as prognostic indicators in dogs. Data from 17 dogs which were scheduled to undergo elective craniotomy for brain tumor surgery from 2009 to 2012 were included. Of these, five (29. Read More

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https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_18
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http://dx.doi.org/10.1292/jvms.18-0475DOI Listing
April 2019
2 Reads

Midazolam: Safety of use in palliative care: A systematic critical review.

Biomed Pharmacother 2019 Apr 10;114:108838. Epub 2019 Apr 10.

Department of Palliative Medicine, Poznan University of Medical Sciences, Poland.

Purpose: The undesired effects of midazolam can be life-threatening. This paper delineates the findings related to the pharmacokinetics, adverse effects and drug-drug interactions as well as associated therapeutic implications for safe midazolam use.

Methods: A systematic review of literature was conducted. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322193059
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http://dx.doi.org/10.1016/j.biopha.2019.108838DOI Listing
April 2019
4 Reads

Long-term seizure outcome in patients with status epilepticus due to acute encephalitis.

Seizure 2019 Apr 8;69:70-75. Epub 2019 Apr 8.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Purpose: To investigate the long-term seizure outcome in patients with convulsive status epilepticus (CSE) due to acute encephalitis and identify early predictors for terminal seizure remission.

Methods: Based on a prospective registry of CSE, consecutive patients with CSE due to acute encephalitis were enrolled from July 2009 to November 2017, with follow-up ending in November 2018. Variables during hospital stay, seizure outcomes within 1 month after status epilepticus (SE), and seizure outcomes within 3 months after acute phase of encephalitis were assessed for predicting terminal seizure freedom. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311193010
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http://dx.doi.org/10.1016/j.seizure.2019.04.005DOI Listing
April 2019
2 Reads

Burden and epidemiology of status epilepticus in infants, children, and adolescents: A population-based study on German health insurance data.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University, Frankfurt am Main, Germany.

Objective: Status epilepticus (SE) is an important medical emergency condition with particularly unfavorable outcome in refractory and superrefractory SE (SRSE). The economic impact of SE and especially of SRSE in the pediatric population remains unclear. We aimed to determine the burden of illness of SE in a pediatric patient population. Read More

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http://dx.doi.org/10.1111/epi.14729DOI Listing
April 2019
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Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.

Brain Res Bull 2019 Apr 9. Epub 2019 Apr 9.

Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, "Dr. Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, IMSS, Ciudad de México, México. Electronic address:

During critical periods of neurodevelopment, the immature brain is susceptible to neuronal hyperexcitability, alterations such as hyperthermia, hypoxia, brain trauma or a preexisting neuroinflammatory condition can trigger, promote and prolong epileptiform activity and facilitate the development of epilepsy. The goal of the present study was to evaluate the long-term neuroprotective effects Magnolia officinalis extract, on a model of recurrent status epilepticus (SE) in immature rats. Sprague-Dawley rats were treated with kainic acid (KA) (3 mg/kg, dissolved in saline solution) beginning at day 10 P N every 24 hrs for five days (10 P N-14PN). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.003DOI Listing
April 2019
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Seizure characteristics, treatment, and outcome in autoimmune synaptic encephalitis: A long-term study.

Epilepsy Behav 2019 Apr 8;94:198-203. Epub 2019 Apr 8.

Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Objectives: The objective of this study was to report seizure characteristics, long-term outcome, and potential factors associated with persistent seizures in patients with autoimmune synaptic encephalitis (ASE).

Method: Clinical data and courses of 52 patients with ASE who presented with seizures at the Department of Neurology of the First Hospital of Jilin University from January 2015 to August 2017 were reviewed. Seizure outcomes were assessed with a median follow-up duration of 30 months (8-40 months). Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.10.038DOI Listing
April 2019
1 Read

Weaning from antiseizure drugs after new onset status epilepticus.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Objective: In patients with status epilepticus (SE) without prior epilepsy, there are limited data on the safety of discontinuing antiseizure drugs (ASDs) after seizure control. We aimed to describe seizure recurrence when weaning from ASDs following new onset SE (NOSE).

Methods: Retrospective review of adult patients with NOSE admitted to Mayo Clinic, Rochester, Minnesota between January 1, 1990 and December 31, 2015 was performed. Read More

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http://dx.doi.org/10.1111/epi.14730DOI Listing
April 2019
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Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.

Cryptogenic temporal lobe epilepsy develops in the absence of identified brain injuries, infections, or structural malformations, and in these cases, an unidentified pre-existing abnormality may initiate febrile seizures, hippocampal sclerosis, and epilepsy. Although a role for GABAergic dysfunction in epilepsy is intuitively obvious, no causal relationship has been established. In this study, hippocampal GABA neurons were targeted for selective elimination to determine whether a focal hippocampal GABAergic defect in an otherwise normal brain can initiate cryptogenic temporal lobe epilepsy with hippocampal sclerosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14723
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http://dx.doi.org/10.1111/epi.14723DOI Listing
April 2019
8 Reads

[Postictal pulmonary oedema: a review of the literature].

Rev Neurol 2019 Apr;68(8):339-345

Pontificia Universidad Javeriana, Bogota DC, Colombia.

Introduction: Postictal neurogenic pulmonary oedema is an infrequent condition of varying severity, probably related to sudden unexpected death in epilepsy (SUDEP). It is more frequent in patients with generalised tonic-clonic seizures of long duration or with status epilepticus.

Aim: Based on a review of the literature, the aim is to describe the clinical characteristics, pathophysiology, radiological findings, treatment and prognosis of patients with postictal pulmonary oedema. Read More

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http://dx.doi.org/10.33588/rn.6808.2018356DOI Listing

Duration of therapeutic coma and outcome of refractory status epilepticus.

Epilepsia 2019 Apr 7. Epub 2019 Apr 7.

Department of Neurology/Epilepsy Center, University of Alabama at Birmingham, Birmingham, Alabama.

Objective: Examine the association of duration of therapeutic coma (TC) with seizure recurrence, morbidity, and mortality in refractory status epilepticus (RSE). Define an optimal window for TC that provides sustained seizure control and minimizes complications.

Methods: Retrospective, observational cohort study involving patients who presented with RSE to the University of Alabama at Birmingham or the University of California at San Francisco from 2010 to 2016. Read More

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http://dx.doi.org/10.1111/epi.14706DOI Listing

Epilepsy-Induced Reduction in HCN Channel Expression Contributes to an Increased Excitability in Dorsal, But Not Ventral, Hippocampal CA1 Neurons.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 2.

Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712.

CA1 neurons in epileptic animals are vulnerable to selective changes in ion channel expression, called acquired channelopathies, which can increase the excitability of a neuron. Under normal conditions there is a gradient of ion channel expression and intrinsic excitability along the longitudinal, dorsoventral axis of hippocampal area CA1 of the rodent. Many of these channels, including M-channels, GIRK channels and HCN channels, all have dorsoventral expression gradients that might be altered in rodent models of epilepsy. Read More

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http://dx.doi.org/10.1523/ENEURO.0036-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449163PMC
April 2019
1 Read

Subacute Encephalopathy With Seizures in Alcoholics Syndrome: A Subtype of Nonconvulsive Status Epilepticus.

Epilepsy Curr 2019 Mar-Apr;19(2):77-82

4 Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.

A recent assessment of the classification of nonconvulsive status epilepticus (NCSE) has incorporated the specific electroencephalographic (EEG) patterns on a syndromic basis. Such a clinical EEG syndromic approach may enable more accurate and expedited diagnosis of particular subtypes of NCSE so as to improve therapy. Herein, we review the characteristics of subacute encephalopathy with seizures in alcoholics syndrome, a subtype of focal NCSE occurring in chronic alcoholism with specific features, including encephalopathy, lateralized periodic discharges on the EEG, chronic microvascular ischemia on neuroimaging studies, and possible recurrence when chronic antiseizure treatment is stopped. Read More

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http://dx.doi.org/10.1177/1535759719835676DOI Listing
April 2019
2 Reads

A New Hose to Extinguish the FIRES?

Authors:
Nicolas Gaspard

Epilepsy Curr 2019 Mar-Apr;19(2):86-87

Tocilizumab Treatment for New Onset Refractory Status Epilepticus Jun JS, Lee ST, Kim R, Chu K, Lee SK. Ann Neurol. 2018;84(6):940-945. Read More

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http://dx.doi.org/10.1177/1535759719835363DOI Listing

Clinical characteristics and factors associated with short-term prognosis in adult patients with autoimmune encephalitis of non-neoplastic etiology.

Neurol Sci 2019 Apr 7. Epub 2019 Apr 7.

Department of Neurology, Shengjing Hospital, China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, People's Republic of China.

Background: Reports that autoimmune encephalitis (AE) is associated with antibodies have increased; however, little is known about the distribution of clinical symptoms, imaging changes, and prognostic factors in patients with AE of non-neoplastic etiology. Accordingly, we evaluated the clinical characteristics and factors associated with short-term prognosis.

Methods: From January 2016 to June 2018, 31 adult patients were diagnosed with AE of non-neoplastic etiology at Shengjing Hospital of China Medical University and their demographic and clinical characteristics were abstracted. Read More

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http://dx.doi.org/10.1007/s10072-019-03883-7DOI Listing
April 2019
3 Reads

[Vomiting as a symptom of epilepsy. Panayitopoulos Syndrome - review of the literature and own experience].

Dev Period Med 2019 ;23(1):28-33

Klinika Pediatrii Alergologii i Gastroenterologii Collegium Medicum w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, Polska.

Vomiting is a common sign of illness in the pediatric population. Its etiology is diversified, ranging from mild functional disorders to severe life-threatening systemic diseases. Vomiting most often occurs in the course of gastrointestinal tract diseases, however, it may also coexist with numerous other ailments located outside the GI tract. Read More

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January 2019
3 Reads

Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.

Brain Res Bull 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China; Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China; Beijing Key Laboratory of Neurostimulation, Beijing, 100070, China. Electronic address:

Background: Mesial temporal lobe epilepsy (mTLE) is the most common type of refractory epilepsy, and non-human primate (NHP) models are important to investigate its mechanism and therapy. However, previous mTLE-NHP models have some defects.

Methods: Thirteen rhesus monkeys were randomly assigned to a control group and epilepsy group. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.002DOI Listing
April 2019
2 Reads

A school-aged boy with super-refractory status epilepticus secondary to cortical dysplasia treated with dexmedetomidine.

J Clin Neurosci 2019 Apr 3. Epub 2019 Apr 3.

University of Florida, Department of Pediatrics, Division of Neurology, 1600 SW Archer Road, Gainesville, FL 32608, United States. Electronic address:

This case report details a novel approach to the management of super-refractory status epilepticus (SRSE) in a boy with new-onset seizures progressing to SRSE. After exhausting multiple medications, dexmedetomidine, an α2-adrenoreceptor agonist used for sedation, stopped his SRSE. Dexmedetomidine provides a unique mechanism of action to treat this condition. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.050DOI Listing
April 2019
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Systematic review and meta-analysis of propofol versus barbiturates for controlling refractory status epilepticus.

BMC Neurol 2019 Apr 6;19(1):55. Epub 2019 Apr 6.

Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No.119, Nansihuanxi Road, Fengtai District, Beijing, 100070, China.

Background: Several studies have compared the efficacy and safety of propofol and barbiturates in the treatment of refractory status epilepticus (RSE). This study aims to quantitatively assess the advantages and disadvantages of propofol and barbiturates in controlling RSE.

Methods: We searched for studies with relevant data from the PubMed, Embase, Ovid, Cochrane Library, Springer Link, Web of Science, and China National Knowledge Infrastructure databases. Read More

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http://dx.doi.org/10.1186/s12883-019-1281-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451279PMC
April 2019
2 Reads

Intravenous use of valproic acid in status epilepticus is associated with high risk of hyperammonemia.

Seizure 2019 Mar 28;69:20-24. Epub 2019 Mar 28.

Department of Perioperative and Intensive Care, County Hospital Ryhov, Jönköping, Sweden.

Purpose: The aim of the study was to examine the frequency of hyperammonemia secondary to valproic acid treatment in status epilepticus and to describe the characteristics of the patients.

Methods: All patients with established status epilepticus during 2014 to 2016 at Ryhov County Hospital were identified in a retrospective case series. Clinical and laboratory findings were collected from electronic medical files and the Metavision database at the intensive care unit (ICU). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.020DOI Listing
March 2019
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Infection with HHV-6 and its role in epilepsy.

Epilepsy Res 2019 Mar 29;153:34-39. Epub 2019 Mar 29.

Center for Neuroscience, Children's National Medical Center, George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

Infection with Human Herpesvirus-6 (HHV-6) has been associated with different epilepsy syndromes, including febrile seizures and status epilepticus, acute symptomatic seizures secondary to encephalitis and temporal lobe epilepsy. This neurotropic DNA virus is ubiquitous and primary infection occurs in up to 80% of children by age two years. While two viral variants have been identified, HHV-6B is the one that has been primarily linked to disease in humans, including epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183062
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.016DOI Listing
March 2019
3 Reads

Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.

Brain Dev 2019 Apr 2. Epub 2019 Apr 2.

Genetic and Metabolic Department, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Objective: EAST syndrome comprises of epilepsy, ataxia, sensorineural deafness, and tubulopathy. It is caused by a mutation in KCNJ10 gene. Less than thirty cases have been reported in the literature with emphasis on genetic mutation and renal tubulopathy. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.03.009DOI Listing
April 2019
2 Reads

Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis.

J Vet Intern Med 2019 Apr 3. Epub 2019 Apr 3.

Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Science, Aichi, Japan.

A 7-year-old neutered female domestic shorthaired cat born in Poland and then moved to Japan presented to the local clinic with recent onset of convulsive cluster seizures and status epilepticus. Magnetic resonance imaging revealed bilateral swelling of the hippocampus with T2 hyperintensity and contrast enhancing image, suggesting hippocampal necrosis. The cat completely recovered after treatment with antiepileptic drugs (AED) and administration of prednisolone (1 mg/kg PO q24h for 4 days and tapered). Read More

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http://dx.doi.org/10.1111/jvim.15492DOI Listing
April 2019
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Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis.

Biomed Res Int 2019 28;2019:4518160. Epub 2019 Feb 28.

Institute of Chemical Biology, Ilia State University, 3/5 K. Cholokashvili Avenue, 0162 Tbilisi, Georgia.

Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available. Occurrence of spontaneous seizures in epilepsy is preceded by numerous functional and structural pathophysiological reorganizations in the brain-a process called epileptogenesis. Treatment strategies targeting this process may be efficient for preventing spontaneous recurrent seizures (SRS) in epilepsy, or for modification of disease progression. Read More

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http://dx.doi.org/10.1155/2019/4518160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421025PMC
February 2019
2 Reads

Role of Epileptic Activity in Older Adults With Delirium, a Prospective Continuous EEG Study.

Front Neurol 2019 19;10:263. Epub 2019 Mar 19.

Neurology Department, ULB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Delirium occurs in up to 50 % of hospitalized old patients and is associated with increased morbidity and mortality. Acute medical conditions favor delirium, but the pathophysiology is unclear. Preliminary evidence from retrospective and prospective studies suggests that a substantial minority of old patients with unexplained delirium have non-convulsive seizures or status epilepticus (NCSE). Read More

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http://dx.doi.org/10.3389/fneur.2019.00263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434717PMC
March 2019
3 Reads

Mouse model of human poisonings with tetramethylenedisulfotetramine: Characterization of the effect of exposure route on syndrome outcomes.

Toxicol Lett 2019 Jun 30;308:50-55. Epub 2019 Mar 30.

Department of Public Health, Division of Environmental Health Science, School of Health Sciences and Practice, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, New York, 10595, USA; Department of Cell Biology and Anatomy, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, New York, 10595, USA; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Rutgers-Robert Wood Johnson Medical School, Piscataway, 675 Hoes Ln W, New Jersey, 08854, USA.

Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, experimental studies have primarily utilized parenteral routes. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.03.014DOI Listing
June 2019
3 Reads

Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.

Neurobiol Dis 2019 Mar 30. Epub 2019 Mar 30.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, United States. Electronic address:

Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and military personnel. CNA-induced acute effects on the nervous system have been known for some time and the long-term consequences are beginning to emerge. In this study, we used diisopropylfluorophosphate (DFP), a seizurogenic CNA to investigate the long-term impact of its acute exposure on the brain and its mitigation by an inducible nitric oxide synthase (iNOS) inhibitor, 1400W as a neuroprotectant in the rat model. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.03.031DOI Listing
March 2019
2 Reads
5.078 Impact Factor

Optimal dosing regimen of phenytoin for Korean epilepsy patients: from premature babies to the elderly.

J Pharm Sci 2019 Mar 30. Epub 2019 Mar 30.

Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Phenytoin has been decreasingly used due to the high inter-individual variability in drug concentration and the narrow therapeutic window. In spite of such drawbacks, phenytoin is still essential as a second-line therapy for status epilepticus when patients are resistant to benzodiazepines. This study aimed to develop a population pharmacokinetic model of phenytoin and to propose the optimal dose regimen of phenytoin in Korean epilepsy patients. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.03.022DOI Listing
March 2019
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A De Novo Dominant Negative Mutation in DNM1L Causes Sudden Onset Status Epilepticus with Subsequent Epileptic Encephalopathy.

Neuropediatrics 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, Kinderklinik Muenchen Schwabing, Klinikum Schwabing, StKM GmbH und Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Mitochondrial dynamics such as fission and fusion play a vital role in normal brain development and neuronal activity. encodes a dynamin-related protein 1 (Drp1), which is a GTPase essential for proper mitochondrial fission. The clinical phenotype of mutations depends on the degree of mitochondrial fission deficiency, ranging from severe encephalopathy and death shortly after birth to initially normal development and then sudden onset of refractory status epilepticus with very poor neurologic outcome. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685217
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http://dx.doi.org/10.1055/s-0039-1685217DOI Listing
April 2019
5 Reads

Prevalence of electrographic seizure in dogs and cats undergoing electroencephalography and clinical characteristics and outcome for dogs and cats with and without electrographic seizure: 104 cases (2009-2015).

J Am Vet Med Assoc 2019 Apr;254(8):967-973

Objective: To determine the prevalence of electrographic seizure (ES) and electrographic status epilepticus (ESE) in dogs and cats that underwent electroencephalography (EEG) because of suspected seizure activity and to characterize the clinical characteristics, risk factors, and in-hospital mortality rates for dogs and cats with ES or ESE.

Design: Retrospective case series.

Animals: 89 dogs and 15 cats. Read More

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http://dx.doi.org/10.2460/javma.254.8.967DOI Listing
April 2019
3 Reads

Communication Challenges: A Spotlight on New-Onset Refractory Status Epilepticus.

Mayo Clin Proc 2019 Mar 29. Epub 2019 Mar 29.

Division of Critical Care Neurology, Department of Neurology, Mayo Clinic, Rochester, MN.

New-onset refractory status epilepticus (NORSE) is a rare, potentially devastating condition that occurs abruptly in previously healthy patients of any age but most commonly in children and young adults. It has an unpredictable clinical course requiring immediate, often prolonged, critical care support with multiple specialists involved and frequently results in severe life-altering sequelae or death. Communication in NORSE is challenging because its etiology in a given patient is initially unknown (and often remains so), the clinical course and outcome are unpredictable, and many health care team members are involved in the care of a patient. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.12.004DOI Listing
March 2019
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TrkB-Shc signaling protects against hippocampal injury following status epilepticus.

J Neurosci 2019 Mar 29. Epub 2019 Mar 29.

Department of Neurobiology

Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy for which only symptomatic therapy is available. One cause of TLE is an episode of prolonged seizures (status epilepticus, SE). Understanding the molecular signaling mechanisms by which SE transforms a brain from normal to epileptic may reveal novel targets for preventive and disease-modifying therapies. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2939-18.2019DOI Listing
March 2019
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Status epilepticus associated with Mycoplasma pneumoniae encephalitis in children: good prognosis following early diagnosis and treatment.

Chin Med J (Engl) 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.

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http://dx.doi.org/10.1097/CM9.0000000000000233DOI Listing
March 2019
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Management of status epilepticus in children prior to medical retrieval: Deviations from the guidelines.

J Paediatr Child Health 2019 Mar 28. Epub 2019 Mar 28.

Department of Paediatric Neurology, Sydney Children's Hospital, Sydney, New South Wales, Australia.

Aim: To evaluate the influence of adherence to treatment guidelines on outcomes in children presenting with status epilepticus (SE) using the Newborn and Paediatric Emergency Transport Service, New South Wales prospective registry.

Methods: We reviewed the treatment of children with SE, transported by the Newborn And Paediatric Emergency Transport Service to a tertiary paediatric hospital, over 1 year. We evaluated variation in management from the New South Wales clinical practice guideline. Read More

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http://dx.doi.org/10.1111/jpc.14448DOI Listing

Critique of the 2017 epileptic seizure and epilepsy classifications.

Epilepsia 2019 Mar 28. Epub 2019 Mar 28.

Neurology Department and Grenoble Institute of Neurosciences, National Institute of Health and Medical Research U-1216, Grenoble Alpes University Hospital, Grenoble, France.

This article critiques the International League Against Epilepsy (ILAE) 2015-2017 classifications of epilepsy, epileptic seizures, and status epilepticus. It points out the following shortcomings of the ILAE classifications: (1) they mix semiological terms with epileptogenic zone terminology; (2) simple and widely accepted terminology has been replaced by complex terminology containing less information; (3) seizure evolution cannot be described in any detail; (4) in the four-level epilepsy classification, level two (epilepsy category) overlaps almost 100% with diagnostic level one (seizure type); and (5) the design of different classifications with distinct frameworks for newborns, adults, and patients in status epilepticus is confusing. The authors stress the importance of validating the new ILAE classifications and feel that the decision of Epilepsia to accept only manuscripts that use the ILAE classifications is premature and regrettable. Read More

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http://dx.doi.org/10.1111/epi.14699DOI Listing
March 2019
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Focal Status Epilepticus With Unilateral Brain Edema: An Expanding Spectrum.

Pediatr Neurol 2019 Feb 8. Epub 2019 Feb 8.

Pediatric Neurology Division, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.02.002DOI Listing
February 2019
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Epilepsy Emergencies: Status Epilepticus, Acute Repetitive Seizures, and Autoimmune Encephalitis.

Continuum (Minneap Minn) 2019 04;25(2):454-476

Purpose Of Review: This article reviews epilepsy emergencies, including status epilepticus, acute repetitive seizures, autoimmune encephalitis, and the current perspective on their diagnosis and treatment.

Recent Findings: Recent guidelines on the treatment of status epilepticus from the Neurocritical Care Society in 2012 and the American Epilepsy Society in 2016 highlight areas of consensus in the treatment of status epilepticus as well as areas of uncertainty. The TRENdS (Treatment of Recurrent Electrographic Nonconvulsive Seizures) trial is the first prospective randomized clinical trial to evaluate the efficacy of IV antiseizure medications in controlling nonconvulsive seizures on continuous EEG. Read More

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http://dx.doi.org/10.1212/CON.0000000000000716DOI Listing
April 2019
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Electroencephalography in Epilepsy Evaluation.

Continuum (Minneap Minn) 2019 04;25(2):431-453

Purpose Of Review: Epilepsy is a heterogeneous disorder that is often associated with abnormal electroencephalogram (EEG) findings. This article provides an overview of common EEG findings in epileptic disorders. The physiologic basis of EEG and intracranial EEG studies is also discussed. Read More

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http://dx.doi.org/10.1212/CON.0000000000000705DOI Listing
April 2019
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Untangling operational failures of the Status Epilepticus Severity Score (STESS).

Neurology 2019 Mar 27. Epub 2019 Mar 27.

From the Clinic for Intensive Care Medicine (R. Sutter, S.S., P.O., R. Spiegel, S.M.), Department of Neurology (R. Sutter, G.M.D.M., S.R.), and Medical Communication and Psychosomatic Medicine (S.H.), University Hospital Basel; Medical Faculty of the University of Basel (R. Sutter, G.M.D.M., S.H., S.R., S.M.), Switzerland; and Department of Neurology (P.W.K.), Johns Hopkins Bayview Medical Center, Baltimore, MD.

Objective: To uncover clinical characteristics leading to false outcome prediction of the Status Epilepticus Severity Score (STESS), a validated and broadly used clinical scoring system for outcome prediction in status epilepticus (SE).

Methods: From 2005 to 2016, adult patients with SE treated at the University Hospital Basel, Switzerland, were included. To assess independent associations of variables differing between patients with false and correct prediction of death (STESS ≥ 3), multivariable logistic regression models were computed using automated selection. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007365DOI Listing
March 2019
8.286 Impact Factor

Non convulsive status epilepticus in the elderly.

Authors:
Sophie Dupont

Geriatr Psychol Neuropsychiatr Vieil 2019 Mar;17(S1):25-30

Epilepsy Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Rehabilitation Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Centre de recherche de l'Institut du cerveau et de la moelle épinière (ICM), UMPC-UMR 7225 CNRS-UMRS 975 Inserm, Paris, France, Université Paris Sorbonne, France.

Non-convulsive status epilepticus (NCSE) is common in the elderly. It most often corresponds to prolonged focal seizures with impaired contact ("complex partial status epilepticus"). A form of de novo absence status epilepticus, much rarer, can also meet. Read More

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http://dx.doi.org/10.1684/pnv.2019.0782DOI Listing
March 2019
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Early seizures after ischemic stroke: focus on thrombolysis.

CNS Spectr 2019 Mar 27:1-13. Epub 2019 Mar 27.

Department of Neurology, Medical School,University of Pecs,Pécs,Hungary.

Introduction: Stroke is a significant underlying cause of epilepsy. Seizures due to ischemic stroke (IS) are generally categorized into early seizures (ESs) and late seizures (LSs). Seizures in thrombolysis situations may raise the possibility of other etiology than IS. Read More

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http://dx.doi.org/10.1017/S1092852919000804DOI Listing
March 2019
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Paroxysmal non-epileptic events in the pediatric emergency department.

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):2188-2193

Department of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Paroxysmal non-epileptic events (PNEs), or pseudoseizures (PS) resemble epileptic seizures. They are considered part of a personality disorder and have a higher incidence among adolescents. Patients describe episodes (lasting up to 20 minutes) of loss of consciousness, twitching or jerking and unusual emotional states. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17265DOI Listing
March 2019
1 Read