974,226 results match your criteria Status Asthmaticus


Flow-Through Flaps in the Absence of an Arterial Gap for Extremity Defect Reconstruction: Minimizing the Donor-Site Morbidity.

J Reconstr Microsurg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Background:  The use of flow-through flaps was popularized in the early 1990s by Costa, Soutar and Lamberty in cases where an arterial gap was present or a major artery of the limb was damaged. We hypothesized that flow-through flaps can be used in all extremity reconstruction cases, where there is an indication for a free-flap, irrespective of the existence of arterial defect due to its many advantages while not increasing the flap loss significantly.

Methods:  A retrospective study was performed by examining patient status and surgery reports of all patients who underwent extremity reconstruction with a flow-through flap from January 2011 to January 2016. Read More

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December 2018

Ambient PM air pollution and cardiovascular disease prevalence: Insights from the 33 Communities Chinese Health Study.

Environ Int 2018 Dec 14;123:310-317. Epub 2018 Dec 14.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM (≤1. Read More

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December 2018

Association of quality of life with disease characteristics and treatment outcomes in patients with advanced gastric cancer: Exploratory analysis of RAINBOW and REGARD phase III trials.

Eur J Cancer 2018 Dec 14;107:115-123. Epub 2018 Dec 14.

Institute of Clinical Cancer Research (IKF), University Cancer Center, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. Electronic address:

Background: Inadequate understanding of interpretation of quality of life (QoL) instruments leads to unsatisfactory data reporting and clinical decision-making, including in gastric cancer care.

Materials And Methods: Pooled QoL data from two phase III studies of ramucirumab with or without paclitaxel in previously treated patients with gastric or gastroesophageal junction cancer were used to explore associations with clinical attributes, including tumour response, disease measurability and performance status (PS). The European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire (QLQ)-C30 was used in both studies. Read More

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December 2018

Association between ambient particulate matter air pollution and ST-elevation myocardial infarction: A case-crossover study in a Chinese city.

Chemosphere 2018 Dec 12;219:724-729. Epub 2018 Dec 12.

Department of Cardiology, Yancheng Hospital Affiliated to Xuzhou Medical University and the First Hospital of Yancheng, Yancheng, 224006, China. Electronic address:

Background: Abundant epidemiological studies have revealed that short-term exposure to ambient air pollution increased the incidence of ischemic heart diseases. However, few investigations have explored the association between air pollution and ST-elevation myocardial infarction (STEMI), one major subtype of such events.

Methods: We conducted a time-stratified case-crossover study in two major hospitals of Yancheng, a city in East China, from January 2015 to February 2018. Read More

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December 2018

Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic.

Ecotoxicol Environ Saf 2018 Dec 14;170:513-520. Epub 2018 Dec 14.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China. Electronic address:

Arsenic poses a profound health risk including male reproductive dysfunction upon prolonged exposure. Histone methylation is an important epigenetic driver; however, its role in arsenic- induced steroidogenic pathogenesis remains obscure. In current study, we investigated the effect of histone H3K9 tri-methylation (H3K9me3) on expression pattern of steroidogenic genes in rat testis after long-term arsenic exposure. Read More

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December 2018

Infant motor skill predicts later expressive language and autism spectrum disorder diagnosis.

Infant Behav Dev 2018 Dec 14;54:37-47. Epub 2018 Dec 14.

Center for Autism and Related Disorders, Kennedy Krieger Institute, 3901 Greenspring Ave, Baltimore, MD 21211, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

Motor difficulties may be an early Autism Spectrum Disorder (ASD) risk indicator and may predict subsequent expressive language skills. Further understanding of motor functioning in the first year of life in children with ASD is needed. We examined motor skills in 6-month-olds (n = 140) at high and low familial risk for ASD using the Peabody Developmental Motor Scales (Grasping, Visual-Motor Integration, and Stationary subscales). Read More

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December 2018

Status of antimicrobial stewardship programs in Nigerian tertiary healthcare facilities; findings and implications.

J Glob Antimicrob Resist 2018 Dec 14. Epub 2018 Dec 14.

Division of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom; Health Economics Centre, Liverpool University Management School, Chatham Street, Liverpool, UK. Electronic address:

Objectives: The problem of antimicrobial resistance (AMR) is increasing worldwide with health-related and economic consequences. This is a concern in Africa, including Nigeria the most populous country in Africa, with its high rates of infectious diseases. Approaches to reducing AMR include instigating antimicrobial stewardship programs (ASPs) in hospitals. Read More

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December 2018

Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.

Neuroimage 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA.

White matter microstructure can be measured with diffusion tensor imaging (DTI). While increasing age is a predictor of white matter (WM) microstructure changes, roles of other possible modifiers, such as cardiovascular risk factors, APOE ε4 allele status and biological sex have not been clarified. We investigated 665 cognitively normal participants from the Baltimore Longitudinal Study of Aging (age 50-95, 56. Read More

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December 2018

Regulation of asymmetries in the kinetics and protein numbers of bacterial gene expression.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Biosystem Dynamics, BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, 33101 Tampere, Finland. Electronic address:

Genetic circuits change the status quo of cellular processes when their protein numbers cross thresholds. We investigate the regulation of RNA and protein threshold crossing propensities in Escherichia coli. From in vivo single RNA time-lapse microscopy data from multiple promoters, mutants, induction schemes and media, we study the asymmetry and tailedness (quantified by the skewness and kurtosis, respectively) of the distributions of time intervals between transcription events. Read More

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December 2018

One-Year Survival and Neurologic Outcomes after Pediatric Open-Chest Cardiopulmonary Resuscitation.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.

Background: Limited data exist regarding neurobehavioral outcomes of children treated with open-chest cardiopulmonary resuscitation (CPR). Our objective was to describe neurobehavioral outcomes one year post-arrest among children who received open-chest CPR during in-hospital cardiac arrest; and explore factors associated with one-year survival and survival with good neurobehavioral outcome.

Methods: The study is a secondary analysis of the Therapeutic Hypothermia after Pediatric Cardiac Arrest In-Hospital Trial. Read More

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December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

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December 2018

The CbrB Regulon: Promoter dissection reveals novel insights into the CbrAB expression network in Pseudomonas putida.

PLoS One 2018 17;13(12):e0209191. Epub 2018 Dec 17.

Universidad Pablo de Olavide, Centro Andaluz de Biología del Desarrollo/ Consejo Superior de Investigaciones Científicas/ Junta de Andalucía, Seville, Spain.

CbrAB is a high ranked global regulatory system exclusive of the Pseudomonads that responds to carbon limiting conditions. It has become necessary to define the particular regulon of CbrB and discriminate it from the downstream cascades through other regulatory components. We have performed in vivo binding analysis of CbrB in P. Read More

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December 2018

Disclosure of HIV serostatus and condomless sex among men living with HIV/AIDS in Florida.

PLoS One 2018 17;13(12):e0207838. Epub 2018 Dec 17.

Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States of America.

Despite campaigns to increase safer sex practices, there are people living with HIV/AIDS (PLWH) who do not disclose their HIV status to sexual partners and engage in condomless sex. The purpose of this research was to: 1) describe factors associated with disclosure of HIV status to sexual partners; and 2) determine if disclosure and/or receipt of prevention counseling are independently associated with condomless sex. We used the Florida Medical Monitoring Project to analyze data from 376 HIV positive men with more than one sexual partner. Read More

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December 2018

Insights into life after sport for Spanish Olympians: Gender and career path perspectives.

PLoS One 2018 17;13(12):e0209433. Epub 2018 Dec 17.

Department of Social Sciences Applied to Sport, Physical Activity and Leisure, Sport Sciences Faculty, Universidad Politécnica de Madrid, Madrid, Spain.

The aims of this study were: i) to examine if Dual Career (DC) pathways are independent of gender, ii) to evaluate whether those athletes who followed a DC experienced less difficulty in their integration into the labor force than the athletes devoted entirely to sport regardless of gender, as well as iii) to analyze whether the type of career path chosen was related with the current labor status, and if differences exist between men and women athletes. A quantitative, cross-sectional, and descriptive study was used based on an ad hoc questionnaire. Two-hundred and twenty-eight retired Olympic athletes completed a questionnaire. Read More

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December 2018

HIV screening among patients seeking care at Xuanwu Hospital: A cross-sectional study in Beijing, China, 2011-2016.

PLoS One 2018 17;13(12):e0208008. Epub 2018 Dec 17.

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Objectives: One-third of people living with HIV in China are still unaware of their status, so we sought to better understand HIV testing in the general hospital setting in China.

Methods: A cross-sectional study was conducted using the electronic medical records of all patients who attended Xuanwu Hospital in Beijing, January 1, 2011 to December 31, 2016. HIV screening and detection rates and characteristics of patients diagnosed with HIV were assessed. Read More

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December 2018

Influence of androgen deprivation therapy on serum urate levels in patients with prostate cancer: A retrospective observational study.

PLoS One 2018 17;13(12):e0209049. Epub 2018 Dec 17.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objectives: Although estrogenic modulation of serum urate levels is well-known, the androgenic effect on urate homeostasis remains controversial. We investigated the effect of androgen deprivation therapy (ADT) on serum urate levels.

Methods: We retrospectively enrolled a total of 489 prostate cancer patients with available serum urate levels at baseline and 3 and 6 months after ADT (n = 150) or prostate surgery (n = 339). Read More

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December 2018

Level and determinants of birth preparedness and complication readiness among pregnant women: A cross sectional study in a rural area in Bangladesh.

PLoS One 2018 17;13(12):e0209076. Epub 2018 Dec 17.

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b); Mohakhali, Dhaka, Bangladesh.

Background: Increasing the level of birth preparedness and complication readiness (BP/CR) is one of the key interventions to promote optimal utilization of skilled maternal health services. It is therefore essential to determine the women's ability to recognize the danger signs and the level of BP/CR. This information can be used to design more effective health interventions. Read More

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December 2018

Hepatitis E virus seroprevalence and determinants in various study populations in the Netherlands.

PLoS One 2018 17;13(12):e0208522. Epub 2018 Dec 17.

Department of Infectious Diseases, Public Health Service Amsterdam (GGD), Amsterdam, the Netherlands.

Background: The epidemiology of hepatitis E virus (HEV) is not fully understood. In this study, we assessed putative risk factors for HEV seropositivity in various study populations in the Netherlands.

Methods: Data and samples from five different study populations were analysed: (A) blood donors (n = 5,239), (B) adults reporting a vegetarian life style since the age of 12 years (n = 231), (C) residents of Amsterdam, the Netherlands, with different ethnic backgrounds (n = 1,198), (D) men who have sex with men (MSM) (HIV positive and HIV negative) (n = 197), and (E) persons who use drugs (PWUD) (HIV positive and HIV negative) (n = 200). Read More

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December 2018

NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0007045. Epub 2018 Dec 17.

Department of Nutrition, University of California, Davis, California, United States of America.

Background: Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment. Metabolomics of cerebrospinal fluid (CSF) was explored as a method of differentiating among neurological diseases causing EM using a single CSF sample.

Methodology/principal Findings: 1H NMR metabolomics was applied to CSF samples from 27 patients with a laboratory-confirmed disease, including Lyme disease or West Nile Virus meningoencephalitis, multiple sclerosis, rabies, or Histoplasma meningitis, and 25 controls. Read More

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December 2018

Effect of High-Dose Statin Pretreatment for Myocardial Perfusion in Patients Receiving Percutaneous Coronary Intervention (PCI): A Meta-Analysis of 15 Randomized Studies.

Med Sci Monit 2018 Dec 17;24:9166-9176. Epub 2018 Dec 17.

Division of Nephrology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND For coronary artery disease, percutaneous coronary intervention (PCI) is the preferred treatment. Reperfusion injury is a common and serious complication of PCI. Studies showed that early statin therapy has a favorable prognostic impact for patients undergoing PCI. Read More

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December 2018

Weight status change from childhood to early adulthood and the risk of adult hypertension.

J Hypertens 2018 Dec 13. Epub 2018 Dec 13.

Department of Epidemiology.

Objective: Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from childhood to early adulthood and adult hypertension in the Chinese population. Read More

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December 2018

The Effect of a Primary Care Provider Incentive Program on Pediatric Emergency Medicine Visits.

Pediatr Emerg Care 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.

Objective: The aim of the study was to analyze the effect of a financial incentive program targeting primary care providers (PCPs) with the goal of decreasing emergency department (ED) utilization.

Methods: We performed a retrospective cohort analysis in a single health maintenance organization comparing ED visit/1000 member-months before and after the physician incentive program in 2009. We compared the median ED visit rate between physicians who did (PIP) and did not participate (non-PIP) from 2009 to 2012. Read More

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December 2018

Frailty in seropositive rheumatoid arthritis patients of working age: a cross-sectional study.

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Social and Preventive Medicine, Centre of Public Health, Medical University of Vienna, Austria.

Objectives: The prevalence of frailty has been widely researched in the elderly population. However, data about people of working age are scarce. The aim of this paper was to assess the prevalence of prefrailty and frailty in rheumatoid arthritis (RA) patients of working age, and to assess factors associated with prefrailty/frailty. Read More

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November 2018

Well on wheels intervention: Satisfaction with life and health for adults with spinal cord injuries.

J Spinal Cord Med 2018 Dec 17:1-9. Epub 2018 Dec 17.

c Department of Physical Medicine and Rehabilitation , University of Michigan , Ann Arbor , Michigan , USA.

Objective/background: To examine how demographic and injury characteristics identify satisfaction with life (SWL), and assess the differential effects of a wellness intervention by baseline SWL groups.

Design: Baseline and longitudinal analysis of a randomized controlled pilot intervention using decision tree regression and linear mixed models.

Setting: Community based. Read More

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December 2018

Reversibility of castration resistance status after Radium-223 dichloride treatment: Clinical evidence and Review of the literature.

Int J Radiat Biol 2018 Dec 17:1-29. Epub 2018 Dec 17.

a Department of Radiological Sciences, Oncology and Anatomical Pathology , Sapienza University of Rome , Viale Regina Elena 324 , 00161 , Rome , Italy.

Purpose: In the history of prostate cancer, some of patients progresses to castration resistant prostate cancer (CRPC) stage and, although new drugs and treatment protocols have been introduced, CRPC presents poor prognosis. This review focused on biological mechanisms, underlying CRPC described in scientific literature in order to explain the reversion of resistance to castration. We present the case of a 73 years-old man, affected by bone metastatic CRPC, early treated with Radium-223 with a complete response. Read More

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December 2018

Hypercholesterolemia and hypertriglyceridemia as biochemical markers of disease in companion rabbits.

Vet Clin Pathol 2018 Dec 17. Epub 2018 Dec 17.

Department of Pathology, Microbiology and Immunology, University of California-Davis School of Veterinary Medicine, Davis, California.

Background: Inflammation has important effects on lipid metabolism, but the relationship between hyperlipidemia, inflammation, and disease remains unknown in rabbits. While rabbits are sensitive to dietary hypercholesterolemia, the etiology of hyperlipidemia when fed non-atherogenic diets is uncertain.

Objectives: This study aimed to determine the association between hypercholesterolemia and patient characteristics, diseases, and select CBC and biochemistry analytes in rabbits, and to measure plasma lipoprotein lipid fractions in rabbits with inflammatory and other diseases. Read More

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December 2018

Identification of LINC01615 as potential metastasis-related long noncoding RNA in hepatocellular carcinoma.

J Cell Physiol 2018 Dec 17. Epub 2018 Dec 17.

Department of General Surgery, Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Hepatocellular carcinoma is one of the most prevalent and fatal cancers. Studying the long noncoding RNA (lncRNA) alterations in hepatocellular carcinoma may lead to new therapeutic strategies. We checked whether there were correlations between The Cancer Genome Atlas expression profiles of the differentially expressed lncRNAs and their DNA methylation status or the copy number variations for hepatocellular carcinoma. Read More

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December 2018

Orthorexia nervosa: A behavioral complex or a psychological condition?

J Behav Addict 2018 Dec 17:1-14. Epub 2018 Dec 17.

1 Psychotherapy and Systems Neuroscience, Justus-Liebig-University Giessen , Giessen, Germany.

Background And Aims: Numerous studies have provided evidence for orthorexia nervosa (ON), an eating pattern characterized by an almost manic obsession for and fixation on healthy eating, to be of epidemiological relevance. However, there is scientific debate on whether it is merely a behavioral or lifestyle phenomenon as compared to a mental disorder. Aim of this cross-sectional study was to explore whether ON is of epidemiological and clinical relevance, and whether ON can be distinguished from other mental health disorders and healthy lifestyle features. Read More

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December 2018

Integrating tumor genomics into studies of the microbiome in colorectal cancer.

Gut Microbes 2018 Dec 17:1-6. Epub 2018 Dec 17.

b Department of Genetics, Cell Biology, and Development , University of Minnesota , Minneapolis , MN , USA.

Although the gut microbiome has been linked to colorectal cancer (CRC) development, associations of microbial taxa with CRC status are often inconsistent across studies. We have recently shown that tumor genomics, a factor that is rarely incorporated in analyses of the CRC microbiome, has a strong effect on the composition of the microbiota. Here, we discuss these results in the wider context of studies characterizing interaction between host genetics and the microbiome, and describe the implications of our findings for understanding the role of the microbiome in CRC. Read More

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December 2018

Socioeconomic status as a moderator of the link between reappraisal and anxiety: Laboratory-based and longitudinal evidence.

Emotion 2018 Dec 17. Epub 2018 Dec 17.

School of Education and Social Policy, Northwestern University.

Cognitive reappraisal reduces anxiety, but we know little about how socioeconomic status (SES) moderates this association. Drawing from developmental, affective, and health psychological frameworks, the present 2 studies investigated SES as a moderator of reappraisal and anxiety using performance-based (Study 1) and self-report (Study 1 and 2) measures of reappraisal; analyzing nonclinical (Study 1) and clinical (Study 2) symptoms of anxiety; and utilizing a small, laboratory-based study (Study 1) and a large-scale 9-year longitudinal study (Study 2). Across studies, findings showed that reappraisal predicted lower anxiety at low levels of SES but did not or less so at high levels of SES. Read More

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December 2018

A six-gene assay as a new biomarker in the blood of patients with colorectal cancer: Establishment and clinical validation.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China.

Colorectal cancer (CRC) is the second most common cancer in men and the third most common in women. Although long-term survival has improved over the past 30 years, at least 50% of patients with CRC will develop metastases after diagnosis. In this study, we examined whether quantifying the mRNAs of six CRC-related genes in the blood could improve disease assessment through detection of circulating tumor cells (CTCs), and thereby improve progression prediction in relapsed CRC patients. Read More

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December 2018

Newborn screening for Prader-Willi syndrome is feasible: Early diagnosis for better outcomes.

Am J Med Genet A 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California.

Prader-Willi syndrome (PWS), is a complex genetic disease affecting 1/15,000 individuals, characterized by lack of expression of genes on the paternal chromosome 15q11-q13 region. Clinical features include central hypotonia, poor suck, learning and behavior problems, growth hormone deficiency with short stature, hyperphagia, and morbid obesity. Despite significant advances in genetic testing, the mean age for diagnosis in PWS continues to lag behind. Read More

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December 2018

SNP-SNP and SNP-environment interactions of potentially functional HOTAIR SNPs modify the risk of hepatocellular carcinoma.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

HOX transcript antisense intergenic RNA (HOTAIR) has been widely regarded as a functional lncRNA contributing to multiple cancers. However, few studies have examined the effect of single nucleotide polymorphisms (SNPs) in HOTAIR on the occurrence and development of hepatocellular carcinoma (HCC). In this study, three potentially functional HOTAIR SNPs (rs17105613, rs12427129 and rs3816153) were selected using bioinformatic tools. Read More

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December 2018

Six genes as potential diagnosis and prognosis biomarkers for hepatocellular carcinoma through data mining.

J Cell Physiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Ultrasound, Taizhou Municipal Hospital, Medical College of Taizhou University, Taizhou, 318000, Zhejiang, China.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the third of cancer mortality worldwide. Although the study of HCC has made great progress, the molecular mechanism and signal pathways of HCC are not yet clear. Therefore, it is necessary to investigate the early diagnosis and prognosis biomarkers for HCC. Read More

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December 2018

Fly control to prevent diarrhoea in children.

Cochrane Database Syst Rev 2018 Dec 17;12:CD011654. Epub 2018 Dec 17.

Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, Sind, Pakistan.

Background: Diarrhoeal disease accounts for millions of child deaths every year. Although the role of flies as vectors of infectious diarrhoea has been established, fly control is not often mentioned as an approach to decrease childhood diarrhoea. Theoretically, fly control for decreasing diarrhoea incidence can be achieved by intervening at four different levels: reduction or elimination of fly breeding sites; reduction of sources that attract houseflies; prevention of contact between flies and disease-causing organisms; and protection of people, food, and food utensils from contact with flies. Read More

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December 2018

Visceral Obesity Relates to Deep White Matter Hyperintensities via Inflammation.

Ann Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Objective: White matter hyperintensities (WMH) are linked to vascular risk factors and increase the risk of cognitive decline, dementia and stroke. We here aimed to determine if obesity contributes to regional WMH using a whole-brain approach in a well-characterized population-based cohort.

Methods: Waist-to-hip ratio (WHR), body mass index (BMI), systolic/diastolic blood pressure, hypertension, diabetes and smoking status, blood glucose and inflammatory markers as well as distribution of WMH were assessed in 1825 participants of the LIFE-adult study (age 20-82 years; BMI 18. Read More

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December 2018

Evaluation of the current status of the eye lens radiation exposure in an Interventional Radiology department.

Med Lav 2018 Dec 20;109(6):471-477. Epub 2018 Dec 20.

Dipartimento di Fisica, Università degli Studi di Napoli Federico II.

Background: Following recent epidemiological studies, which showed tissue reactions from ionizing radiation at significantly lower doses, the 2013/59 EURATOM Directive of 5th December 2013 lowered the limit on the equivalent dose to the eye lens from 150 mSv to 20 mSv per year. Therefore, as a precautionary measure, it is considered appropriate to perform a timely dose monitoring by using specific dosimeters.

Objectives: Analysis of the current state of the eye lens exposures during interventional procedures. Read More

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December 2018

Status survey on enema reduction of paediatric intussusception in China.

J Int Med Res 2018 Dec 16:300060518814120. Epub 2018 Dec 16.

1 Department of Pediatric Surgery, Shengjing Hospital, China Medical University, Shenyang, China.

Objective: Intussusception is a common paediatric abdominal emergency in infants. The first-line treatment of choice in uncomplicated paediatric intussusception is enema reduction. The study aim was to provide an overview of the current national practice of enema reduction of paediatric intussusception in China. Read More

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December 2018

[Study of eating attitudes, behaviour and information-seeking in relation to sociodemographic and psychological factors among adolescents].

Orv Hetil 2018 Dec;159(51):2183-2192

Magatartástudományi Intézet, Általános Orvostudományi Kar Szeged, Szentháromság u. 5., 6722.

Introduction: Nutrition is one of the key factors in health maintainance. So developing appropriate eating habits is very important in adolescence. Dietary behaviour may be influenced by certain aspects of personality, e. Read More

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December 2018

Cardiovascular risk profiling of long-lived people shows peculiar associations with mortality compared with younger individuals.

Geriatr Gerontol Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.

Aim: Centenarians represent a biological model of successful aging because they escaped/postponed most invalidating age-related diseases, such as cardiovascular diseases. The aim of the present study was to clarify whether a favorable cardiovascular risk profile increases the survival chances in long-lived people.

Methods: A total of 355 community-dwelling nonagenarians and centenarians living in Southern Italy were recruited in the study. Read More

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December 2018

Helicobacter pylori eradication improves glycemic control in type 2 diabetic patients with asymptomatic active Helicobacter pylori infection.

J Diabetes Investig 2018 Dec 16. Epub 2018 Dec 16.

Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Aims/introduction: Helicobacter pylori infection is associated with insulin resistance and glycemia in nondiabetes. However, the relationship between Helicobacter pylori infection and glycemia in diabetes remains inconclusive. Therefore, we explored the effect of Helicobacter pylori infection status and its eradication on glycemic control and antidiabetic therapy in type 2 diabetes. Read More

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December 2018

Dietary effect of lemon verbena extract on selected blood parameters and on plasma oxidative profile in Avelignese horses.

Anim Sci J 2018 Dec 16. Epub 2018 Dec 16.

Department of Agricultural, Environmental and Food Sciences, University of Molise, Campobasso, Italy.

The effect of Lippia citriodora extract on selected blood parameters and on plasma oxidative markers in Avelignese horses was evaluated. Twenty-four horses were divided into three groups, consisting of eight animals each. Results of two experimental groups, 0. Read More

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December 2018

Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes and Glycemic Control over Time: The SEARCH for Diabetes in Youth Study.

Pediatr Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Background: The diagnosis of type 1 diabetes (T1D) in youth is often associated with diabetic ketoacidosis (DKA). We aimed to evaluate if the presence of DKA at diagnosis of T1D is associated with less favorable hemoglobin A (HbA1c) trajectories over time.

Methods: The SEARCH for Diabetes in Youth study of 1396 youth aged <20 years with newly diagnosed T1D were followed for up to 13 [median 8 (IQR 6-9)] years post-diagnosis. Read More

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December 2018

Hepatoprotective and antioxidant potential of Pycnogenol® in acetaminophen-induced hepatotoxicity in rats.

Phytother Res 2018 Dec 16. Epub 2018 Dec 16.

Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000, Novi Sad, Serbia.

Pycnogenol® (PYC) has already being used as a food supplement and herbal medicine due to its potent antioxidant properties. The aim of the present study was to examine the protective effect of PYC on acetaminophen-induced acute liver injury in rats. The effect of PYC on acetaminophen-induced hepatotoxicity in rats was examined by determining biochemical parameters, in vitro antioxidant activity, histological assessment, and oxidative status in liver homogenates. Read More

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December 2018

NK cell and macrophages confer prognosis and reflect immune status in osteosarcoma.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Department of Orthopedic, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, Zhejiang, China.

Osteosarcoma (OS) is a common primary malignant bone tumor in young adolescents. About 30% of patients with OS have a recurrence, and the overall survival after OS recurrence is not good. In this study, we aimed to analyze and identify factors that influence prognosis after OS relapse. Read More

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December 2018

Population Pharmacokinetics of the BTK Inhibitor Acalabrutinib and its Active Metabolite in Healthy Volunteers and Patients with B-Cell Malignancies.

Clin Pharmacokinet 2018 Dec 17. Epub 2018 Dec 17.

Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Boston, MA, USA.

Introduction: Bruton tyrosine kinase (BTK) is a key component of B-cell receptor signalling, critical for cell proliferation. Acalabrutinib, a selective, covalent BTK inhibitor, recently received an accelerated approval in relapsed/refractory mantle cell lymphoma. This analysis characterized the population pharmacokinetics (PK) of acalabrutinib and its metabolite ACP-5862. Read More

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December 2018

Diet-Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice.

Hepatol Commun 2018 Dec 10;2(12):1533-1549. Epub 2018 Oct 10.

Sorbonne Université, INSERM Centre de Recherche Saint-Antoine (CRSA), and Institute of Cardiometabolism and Nutrition (ICAN) Paris France.

The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the potential impact of environmental and genetic factors on the development of CF-related cholangiopathy in mice. Cystic fibrosis transmembrane conductance regulator () mice and littermates in a congenic C57BL/6J background were fed a high medium-chain triglyceride (MCT) diet. Read More

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December 2018

Outcome of therapeutic penetrating keratoplasty in advanced infectious keratitis.

J Curr Ophthalmol 2018 Dec 26;30(4):315-320. Epub 2018 Apr 26.

Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun, India.

Purpose: This study aimed to evaluate the anatomical, therapeutic, and functional outcome of therapeutic penetrating keratoplasty (TPK) in terms of success and failure.

Methods: In this retrospective study 57 eyes of 57 patients were reviewed. They had undergone TPK from December 2012 to June 2017. Read More

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December 2018

Deep anterior lamellar keratoplasty: A surgeon's guide.

J Curr Ophthalmol 2018 Dec 10;30(4):297-310. Epub 2018 Jul 10.

Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Brighton, United Kingdom.

Purpose: To review and highlight important practical aspects of deep anterior lamellar keratoplasty (DALK) surgery and provide some useful tips for surgeons wishing to convert to this procedure from the conventional penetrating keratoplasty (PK) technique.

Methods: In this narrative review, the procedure of DALK is described in detail. Important pre, intra, and postoperative considerations are discussed with illustrative examples for better understanding. Read More

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December 2018

Short-course palliative radiation therapy leads to excellent bleeding control: A single centre retrospective study.

Clin Transl Radiat Oncol 2019 Jan 22;14:40-46. Epub 2018 Nov 22.

Department of Gynecologic Oncology, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.

Purpose: To compare and evaluate the utility of varying hemostatic radiotherapy prescriptions for emergent palliation of bleeding tumors.

Materials And Methods: This retrospective study analyzed 112 consecutive patients treated with radiotherapy for emergent palliation of bleeding tumors at an academic institution. Study endpoints included: primary bleeding control; re-bleeding rate after initial control; treatment interruption rate; overall survival; and death within 30 days of treatment. Read More

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January 2019
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