1,132,616 results match your criteria Statistics in Medicine [Journal]


Detecting moderate or complex congenital heart defects in adults from an electronic health records system.

J Am Med Inform Assoc 2018 Dec;25(12):1634-1642

Emory University School of Medicine, Atlanta, GA, USA.

Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population.

Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR). Read More

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December 2018
3 Reads

Implementation of a Stirling number estimator enables direct calculation of population genetics tests for large sequence data sets.

Authors:
Swaine L Chen

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Division of Infectious Diseases, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and Infectious Diseases Group, Genome Institute of Singapore, Singapore.

Motivation: Stirling numbers enter into the calculation of several population genetics statistics, including Fu's Fs. However, as alignments become large (>∼50 sequences), the Stirling numbers required rapidly exceed the standard floating point range. Another recursive method for calculating Fu's Fs suffers from floating point underflow issues. Read More

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December 2018

ModL: exploring and restoring regularity when testing for positive selection.

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Department of Mathematics and Statistics, Dalhousie University, Halifax, NS, Canada.

Motivation: Likelihood ratio tests are commonly used to test for positive selection acting on proteins. They are usually applied with thresholds for declaring a protein under positive selection determined from a chi-square or mixture of chi-square distributions. While it is known that such distributions are not strictly justified due to the statistical irregularity of the problem, the hope has been that the resulting tests are conservative and do not lose much power in comparison with the same test using the unknown, correct threshold. Read More

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December 2018

Cohort Profile: the Office for National Statistics Longitudinal Study (The LS).

Int J Epidemiol 2018 Dec 12. Epub 2018 Dec 12.

Centre for Longitudinal Study Information and User Support (CeLSIUS), Department of Epidemiology and Public Health, University College London, London, UK.

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December 2018

Shorter Relapse-Free Period after Leukocyte Removal Therapy in Younger than Older Patients with Ulcerative Colitis.

Digestion 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Internal Medicine, Saga Medical School, Saga, Japan.

Background: Leukocyte removal therapy (LRT) is an effective treatment for active ulcerative colitis (UC). The present study was performed to evaluate the relapse-free period after LRT and identify risk factors for relapse.

Methods: In total, 94 patients who underwent first-time LRT for remission of moderate to severe UC from April 2004 to March 2016 were enrolled in the present study. Read More

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December 2018
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Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking.

Stem Cell Reports 2018 Dec;11(6):1365-1377

Global Safety Pharmacology, Non-Clinical Safety, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the challenge remains to implement hiPSC-CMs into cardiac de-risking of new chemical entities (NCEs) during preclinical drug development. Here, we used the calcium transient screening assay in hiPSC-CMs to develop a hazard score system for cardiac electrical liabilities. Read More

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December 2018

Inferring symmetric and asymmetric interactions between animals and groups from positional data.

PLoS One 2018 12;13(12):e0208202. Epub 2018 Dec 12.

Department of Mathematics and Statistics, University of Western Australia, Nedlands, Perth, WA, Australia.

Interactions between domestic and wild species has become a global problem of growing interest. Global Position Systems (GPS) allow collection of vast records of time series of animal spatial movement, but there is need for developing analytical methods to efficiently use this information to unravel species interactions. This study assesses different methods to infer interactions and their symmetry between individual animals, social groups or species. Read More

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December 2018

Usefulness of C-MAC video laryngoscope in direct laryngoscopy training in the emergency department: A propensity score matching analysis.

PLoS One 2018 12;13(12):e0208077. Epub 2018 Dec 12.

Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objectives: We determined the usefulness of C-MAC video laryngoscope (C-MAC) as a safe training tool for the direct laryngoscopy technique in the emergency department.

Methods: We retrospectively analyzed an institutional airway registry of adult (≥18 years old) patients from April 2014 through October 2016. In this study, the operator used C-MAC as a direct laryngoscope (DL) with limited access to the screen, and the supervisor instructed the operator via verbal feedback while watching the screen. Read More

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December 2018

Education and work participation among adults with congenital unilateral upper limb deficiency in Norway: A cross-sectional study.

PLoS One 2018 12;13(12):e0207846. Epub 2018 Dec 12.

Innlandet Hospital Trust, Department of Physical Medicine and Rehabilitation, Ottestad, Norway.

Objectives: To describe level of education and work participation among adults with congenital unilateral upper limb deficiency (CUULD) in Norway and to explore associations between work participation and demographic and clinical factors.

Methods: Cross-sectional study. In 2012, a postal questionnaire was sent to 186 persons with congenital limb deficiency (CLD), age ≥ 20 years, registered at the TRS National Resource Center for Rare Disorders. Read More

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December 2018

A new development of non-local image denoising using fixed-point iteration for non-convex ℓp sparse optimization.

PLoS One 2018 12;13(12):e0208503. Epub 2018 Dec 12.

Department of Mathematics, Southern Illinois University-Carbondale, Carbondale, IL, United States of America.

We proposed a new efficient image denoising scheme, which mainly leads to four important contributions whose approaches are different from existing ones. The first is to show the equivalence between the group-based sparse representation and the Schatten-p norm minimization problem, so that the sparsity of the coefficients for each group can be measured by estimating the underlying singular values. The second is that we construct the proximal operator for sparse optimization in ℓp space with p ∈ (0, 1] by using fixed-point iteration and obtained a new solution of Schatten-p norm minimization problem, which is more rigorous and accurate than current available results. Read More

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December 2018

Quality and quantity of leaf litter: Both are important for feeding preferences and growth of an aquatic shredder.

PLoS One 2018 12;13(12):e0208272. Epub 2018 Dec 12.

Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.

The study of leaf litter as a resource for shredders has emerged as a key topic in trophic links in ecology. However, thus far, most studies have emphasized the leaf quality as one of the main determinants of shredder behaviour and growth without simultaneously considering the leaf quantity availability. Nevertheless, the combined effects of leaf quantity and quality on shredder behaviour and growth is particularly crucial to further understand how ecosystem functioning may respond to the increasing flow intermittency due to climate change. Read More

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December 2018

Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.

PLoS One 2018 12;13(12):e0207574. Epub 2018 Dec 12.

Department of Operative Dentistry and Periodontology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In light of the growing antibiotic resistance, the usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against oral infections. The aim of this study was to investigate the antimicrobial and antibiofilm activity of Mediterranean herb extracts against representative oral microorganisms. The extraction procedures and the analysis of the obtained extracts were performed under established experimental conditions. Read More

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December 2018

Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two-component system HptRS.

PLoS One 2018 12;13(12):e0207161. Epub 2018 Dec 12.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.

The success of Staphylococcus aureus as a pathogen is due in part to its ability to adapt to changing environmental conditions using signal transduction pathways, such as metabolite- responsive regulators and two-component systems. S. aureus has a two-component system encoded by the gene pair sav0224 (hptS) and sav0223 (hptR) that regulate the hexose phosphate transport (uhpT) system in response to extracellular glucose-6-phosphate. Read More

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December 2018

Chasing red herrings: Can visual distracters extend the time children take to open child resistant vials?

PLoS One 2018 12;13(12):e0207738. Epub 2018 Dec 12.

School of Packaging, Michigan State University, East Lansing, MI, United States of America.

Background: Unintentional exposure to medications is a noted problem in pediatric populations despite the prevalent use of child-resistant (CR) packaging and educational campaigns informing consumers about appropriate storage.

Objective: Conduct a proof-of concept study that evaluates how package designs that engage the attention of children in meaningless ways affect opening time and number of openings.

Study Design: Non-CR vials with or without distracters were provided to 108 children (24-51 months) in pairs. Read More

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December 2018

Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations.

PLoS One 2018 12;13(12):e0206579. Epub 2018 Dec 12.

Institute of Statistics, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.

Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have been recently developed to decompose tumor subclonal architecture from a collective genome sequencing data. Read More

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December 2018

Novel Application of the Pfirrmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Monash Medical Centre, Clayton, Victoria, Australia.

Study Design: Reliability Study.

Objective: To evaluate the applicability and reliability of 9.4T MRI in the assessment of degenerative disc disease compared to 3T MRI. Read More

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December 2018

Latent Transition Analysis of the Symptom Experience of Cancer Patients Undergoing Chemotherapy.

Nurs Res 2018 Dec 12. Epub 2018 Dec 12.

Research Scientist, Yale School of Nursing, West Haven, CT Professor, Department of Psychiatry & Statistics and Probability, Michigan State University, East Lansing, MI Professor Emeritus, College of Nursing, Michigan State University, East Lansing, MI Professor Emeritus, Department of Family Medicine, Michigan State University, East Lansing, MI Beatrice Retrice Renfield Term Professor of Nursing, Yale Schools of Nursing & Medicine, West Haven, CT.

Background: Symptom clusters reflect the person's experience of multiple co-occurring symptoms. While a variety of statistical methods are available to address the clustering of symptoms, latent transition analysis (LTA) characterizes patient membership in classes defined by the symptom experience and captures changes in class membership over time.

Objectives: The purposes of this paper are to demonstrate the application of LTA to cancer symptom data and to discuss the advantages and disadvantages of LTA relative to other methods of managing and interpreting data on multiple symptoms. Read More

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December 2018

Persistence on apixaban in atrial fibrillation patients: a retrospective multicentre study.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

MA Provider, Milan, Italy.

Aims: Real-world data on treatment persistence, safety and effectiveness of non-Vitamin K antagonist oral anticoagulants (NOACs) play an important role in the assessment of risks and benefits of these drugs. Our aim was to evaluate persistence on treatment, incidence of major bleeding and incidence of a composite endpoint of major events, including all-cause death, myocardial infarction, stroke and systemic thromboembolism, during treatment with apixaban in a cohort of patients with nonvalvular atrial fibrillation (NVAF).

Methods: In this multicentre retrospective observational study, we retrieved data from medical records of five Italian hospitals on patients with a diagnosis of NVAF who initiated apixaban between 1 January 2014 and 31 March 2016 and had a first subsequent visit at the same hospital. Read More

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December 2018

Monitoring haemodynamic response to fluid-challenge in ICU: Comparison of pressure recording analytical method and oesophageal Doppler.

Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anaesthesia, Burn, and Critical Care, Saint-Louis Lariboisière University Hospital (RB, FD, MR, JS, AM, BGC), Department of Anaesthesia and Critical Care, European Hospital Georges-Pompidou, APHP (AN, DD, RP), Paris Diderot University, Sorbonne Paris Cité (AM, BGC), Inserm U942 (AM), Paris Descartes University, Sorbonne Paris Cité (RP), Inserm U1153 (RP) and Inserm U1160, Paris, France (BGC).

Background: The ability of the pressure recording analytical method (PRAM) in tracking change in cardiac output (ΔCO) after a fluid challenge in ICU needs to be evaluated with the most contemporary comparison methods recommended by experts.

Objective: Our objective was to report the trending ability of PRAM in tracking ΔCO after a fluid challenge in ICU and to compare this with oesophageal Doppler monitoring (ODM).

Design: Prospective, observational study. Read More

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December 2018

The effect of task-oriented electromyography-triggered electrical stimulation of the paretic wrist extensors on upper limb motor function early after stroke: a pilot randomized controlled trial.

Int J Rehabil Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey.

The combined effect of task-oriented motor training and electromyography (EMG)-triggered electrical stimulation (ES) has been examined in chronic stroke, but there are no published reports in patients with early stroke. Therefore, the purpose of this study was to determine the short-term and long-term effects of task-oriented EMG-triggered ES on upper limb motor function in acute/subacute stroke. Twenty-seven patients with stroke within the first 3 months after stroke onset were randomly allocated to an experimental group and a control group. Read More

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December 2018
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Narcolepsy, Anesthesia, and Sedation: A Survey of the Perioperative Experience of Patients With Narcolepsy.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Cleveland, Ohio.

Background: Patients with narcolepsy may be at increased perioperative risk due to the interactions among anesthesia, narcolepsy, and narcolepsy medications. This study sought to determine the perioperative experience of narcoleptic patients undergoing anesthesia or sedation, the frequency of perioperative counseling, and self-reported surgical complications.

Methods: A 22-question survey was developed by expert consensus and distributed by the Narcolepsy Network. Read More

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December 2018

Role of Vacuum-Assisted Closure in the Management of Crohn Anal Fistulas.

Adv Skin Wound Care 2018 Dec 13. Epub 2018 Dec 13.

At the Poznań University of Medical Sciences in Poznań, Poland, Jacek Hermann, PhD, is Chair, Department of General and Endocrine Surgery and Gastroenterologic Oncology; Tomasz Banasiewicz is Chair, Department of General and Endocrine Surgery and Gastroenterologic Oncology; and Barbara Kołodziejczak, PhD, is Chair, Department of Computer Science and Statistics. The authors have disclosed no financial relationships related to this article. Submitted January 28, 2018; accepted in revised form May 25, 2018.

Background: Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods.

Objective: To compare NCS with vacuum-assisted closure (VAC) treatment. Read More

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December 2018
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Population differentiation within Anisogramma anomala in North America.

Phytopathology 2018 Dec 12. Epub 2018 Dec 12.

Rutgers The State University of New Jersey, 242612, Department of Plant Biology, New Brunswick, New Jersey, United States ;

Anisogramma anomala (Peck) E. Müller, a biotrophic ascomycete in the order Diaporthales, causes eastern filbert blight (EFB) of hazelnuts (Corylus). Until recently, little has been documented on its genetic diversity and population structure. Read More

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December 2018

Screening, prevention and management of osteoporosis among Canadian adults.

Health Promot Chronic Dis Prev Can 2018 Dec;38(12):445-454

Public Health Agency of Canada, Ottawa, Ontario, Canada.

Introduction: This study provides a benchmark for the nationwide use of osteoporosis screening, prevention and management strategies among Canadians aged 40 years and older (40+) using data collected one year prior to the release of Osteoporosis Canada's latest (2010) clinical practice guidelines.

Methods: Data are from the 2009 Canadian Community Health Survey-Osteoporosis Rapid Response Component. The study sample (n = 5704) was divided into four risk subgroups: (1) osteoporosis diagnosis and major fracture; (2) osteoporosis diagnosis only; (3) major fracture only; or (4) neither osteoporosis diagnosis nor major fracture. Read More

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December 2018

Obesity and healthy aging: social, functional and mental well-being among older Canadians.

Health Promot Chronic Dis Prev Can 2018 Dec;38(12):437-444

Public Health Agency of Canada, Ottawa, Ontario, Canada.

Introduction: Canadians are living longer than before, and a large proportion of them are living with obesity. The present study sought to describe how older participants in the Canadian Longitudinal Study on Aging (CLSA) who are living with obesity are aging, through an examination of measures of social, functional and mental well-being.

Methods: We used data from the first wave of the CLSA for people aged 55 to 85 years in this study. Read More

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December 2018
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Cross-cultural adaptation and validation of Pamela Reed's Self-Transcendence Scale for the Spanish context.

Rev Lat Am Enfermagem 2018 Dec 10;26:e3058. Epub 2018 Dec 10.

Universitat Jaume I, Facultad de Ciencias de la Salud, Castellón, Comunidad Valenciana, Spain.

Objectives: the current study aimed to adapt the Self-Transcendence Scale (STS) to the Spanish context and analyse its psychometric properties.

Method: the STS was administered to a general Spanish population of adults (i.e. Read More

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December 2018

Influence of socio-demographic characteristics in the self-care of people with heart failure.

Rev Bras Enferm 2018 ;71(suppl 6):2604-2611

Universidade Federal do Ceará. Fortaleza, Ceará, Brazil.

Objective: To determine the influence of socio-demographic characteristics in the self-care of people with heart failure (HF).

Method: Cross-sectional, analytical study, held in three private hospitals in Fortaleza, Ceará, Brasil, with 57 hospitalized patients. The data were collected through a demographic characterization form and a self-care assessment scale and were analyzed with inferential statistics, using mean comparison tests. Read More

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January 2018

An Investigation and Suggestions for the Improvement of Brain Death Determination in China.

Chin Med J (Engl) 2018 Dec;131(24):2910-2914

Department of Neurology, Xuanwu Hospital, Capital Medical University, National Health Commission of the People's Republic of China/Brain Injury Evaluation Quality Control Centre, Beijing 100053, China.

Background: Brain death is the irreversible cessation of the function of the brain including the brainstem. In 2013, the Brain Injury Evaluation Quality Control Centre (BQCC) of the National Health and Family Planning Commission issued criteria and practical guidelines for the determination of brain death. This study aimed to evaluate whether the institutions have adopted these guidelines and to make suggestions for the improvement of the current criteria and practical guidelines for brain death determination in China. Read More

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December 2018
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Sources of finance for hospitalized treatment in India: Evidence for policy.

Indian J Public Health 2018 Oct-Dec;62(4):308-310

Vice President and APAC Head of Data Management at ICON, Chennai, Tamil Nadu, India.

A study of sources of finance which the household resorts to, in order to meet the hospitalization expense can be of use to policy makers who may want to work in the direction of providing financial security against hospitalization expenses to the masses. In this view, an attempt has been made to study the sources of finance for hospitalized treatment at an individual level based on criteria such as level of living, socio-economic background, level of care in India, as well as at state level through unit level data of the survey on "Social Consumption related to Health", conducted by National Sample Survey (NSS) during January, 2014 to June, 2014. It has been found that the household's income or saving is not sufficient to meet the expenditure for hospitalized treatment and people have to borrow or arrange finance by other means for hospitalized treatment across the country. Read More

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December 2018

Body mass index and body fat percentage in assessing obesity: An analytical study among the adolescents of Dibrugarh, Assam.

Indian J Public Health 2018 Oct-Dec;62(4):277-281

Professor, Department of Community Medicine, Gauhati Medical College, Guwahati, Assam, India.

Background: Body mass index (BMI) is one of the most commonly used indices to measure the weight status of an individual. However, it takes only height and weight of individual into account. The relative body composition can be calculated regardless of height and weight by body fat percentage (BF%). Read More

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December 2018

Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma.

J Cancer Res Ther 2018 Dec;14(Supplement):S964-S968

Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan, Guangdong 523808, China, Dongguan.

Context: The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a potential target of anticancer drug. This study investigated the mechanism how ganodermanontriol effect the expression of SATB1 and thus inhibits the growth and metastasis in hepatocellular carcinoma (HCC). Read More

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December 2018

Comparison of In-Hospital Bleeding and Cardiovascular Events with High-Dose Bolus Tirofiban and Shortened Infusion to Short-Duration Eptifibatide as Adjunctive Therapy for Percutaneous Coronary Intervention.

Am J Cardiol 2019 Jan 26;123(1):44-49. Epub 2018 Sep 26.

Department of Pharmacy Services, Mayo Clinic, Rochester, Minnesota.

Potent platelet inhibition is one of the most important medical interventions to prevent ischemic complications during and after percutaneous coronary intervention (PCI). Practice has evolved with the introduction of potent oral P2Y inhibitors that provide quick, effective platelet inhibition, and the need for routine glycoprotein IIb/IIIa inhibitors (GPIs) has decreased. Additionally, a shorter duration of GPI infusion has been shown to be safe with adequate oral antiplatelet loading, but clinical outcome data are limited to eptifibatide. Read More

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January 2019
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Psychometric Evaluation of PROMIS Sexual Function and Satisfaction Measures in a Longitudinal Population-Based Cohort of Men With Localized Prostate Cancer.

J Sex Med 2018 Dec 24;15(12):1792-1810. Epub 2018 Oct 24.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: There are multiple treatment options for men with localized prostate cancer that provide similar curative efficacy but differ in their impact on sexual functioning.

Aim: To evaluate the psychometric properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) Sexual Function and Satisfaction (SexFS) measures, including items from versions 1 and 2 of the short forms.

Methods: A population-based cohort of men across North Carolina completed surveys via phone interviews at baseline (prior to treatment) and at 3, 12, and 24 months after cancer treatment initiation. Read More

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December 2018

Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study.

Authors:
S C Bae Y H Lee

Lupus 2018 Dec 12:961203318817832. Epub 2018 Dec 12.

2 Department of Rheumatology, Korea University College of Medicine, Seoul, Korea.

Objectives: This study aimed to examine whether alcohol intake is causally associated with systemic lupus erythematosus (SLE).

Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and an SLE GWAS consisting of 1311 SLE and 1783 control subjects of European descent as the outcome. Read More

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December 2018

The metabolic signature of Primary Biliary Cholangitis and its comparison with Coeliac Disease.

J Proteome Res 2018 Dec 12. Epub 2018 Dec 12.

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by ongoing inflammatory destruction of the interlobular bile ducts, eventually leading to chronic cholestasis and biliary cirrhosis. This study primarily aims to define the metabolomic signature of PBC after comparison with healthy controls (HC). Secondly it aims at evaluating the possible metabolic association between PBC and coeliac disease (CD), an immune-mediated disorder frequently associated with PBC. Read More

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December 2018
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Function-based hypothesis testing in censored two-sample location-scale models.

Lifetime Data Anal 2018 Dec 11. Epub 2018 Dec 11.

Department of Mathematical Sciences, Center for Applied Mathematics and Statistics, New Jersey Institute of Technology, Newark, USA.

Function-based hypothesis testing in two-sample location-scale models has been addressed for uncensored data using the empirical characteristic function. A test of adequacy in censored two-sample location-scale models is lacking, however. A plug-in empirical likelihood approach is used to introduce a test statistic, which, asymptotically, is not distribution free. Read More

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December 2018

Comparison of body weight estimation equations for camels (Camelus dromedarius).

Trop Anim Health Prod 2018 Dec 11. Epub 2018 Dec 11.

Department of Animal Production and Biotechnology, Institut Agronomique et Vétérinaire Hassan II, PO Box 6202, Rabat-Instituts, 10101, Rabat, Morocco.

The objective of the present study was to evaluate the accuracy of six different equations for weight estimation of camels using body measurements as chest girth, height at withers, and hump girth in order to identify the most reliable equation for use in the field. The prediction equations that were compared were those of Boué Revue d'Élevage et de Médecine vétérinaire des Pays tropicaux 3 (1), 13-16, 1949; Graber Revue d'Élevage et de Médecine vétérinaire des Pays tropicaux, 19, 527-543, 1966; Wilson Tropical Animal Health and Production, 10, 19-25, 1978; Field Proceedings of the Khartoum workshop on camels V1, 209-230, 1979; Bucci et al. Indian Veterinary Journal, 61, 26-30, 1984; and Yagil A Handbook for Camel Breeding, 1994 noticed as BW1, BW2, BW3, BW4, BW5, and BW6, respectively. Read More

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December 2018

Multiple Equilibria in a Non-smooth Epidemic Model with Medical-Resource Constraints.

Bull Math Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.

The issue of medical-resource constraints has the potential to dramatically affect disease management, especially in developing countries. We analyze a non-smooth epidemic model with nonlinear incidence rate and resource constraints, which defines a vaccination program with vaccination rate proportional to the number of susceptible individuals when this number is below the threshold level and constant otherwise. To better understand the impact of this non-smooth vaccination policy, we provide a comprehensive qualitative analysis of global dynamics for the whole parameter space. Read More

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December 2018

Fatigue in survivors of malignant melanoma and its determinants: a register-based cohort study.

Support Care Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.

Purpose: Fatigue has found increasing attention as a debilitating and lasting condition of cancer patients. However, it has remained unclear to what degree long-term survivors of malignant melanoma suffer from fatigue. Therefore, this study aimed to determine fatigue and its link with quality of life, aftercare behavior, and mental and physical symptoms among melanoma survivors. Read More

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December 2018

Whole-body low-dose CT recognizes two distinct patterns of lytic lesions in multiple myeloma patients with different disease metabolism at PET/MRI.

Ann Hematol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Institute of Radiology, Padua University School of Medicine, Padua, Italy.

We evaluated differences in density and F-FDG PET/MRI features of lytic bone lesions (LBLs) identified by whole-body low-dose CT (WB-LDCT) in patients affected by newly diagnosed multiple myeloma (MM). In 18 MM patients, 135 unequivocal LBLs identified by WB-LDCT were characterized for inner density (negative or positive Hounsfield unit (HU)), where negative density (HU < 0) characterizes normal yellow marrow whereas positive HU correlates with tissue-like infiltrative pattern. The same LBLs were analyzed by F-FDG PET/DWI-MRI, registering DWI signal with ADC and SUV max values. Read More

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December 2018

Risk of Clinically Relevant Pericardial Effusion After Pediatric Cardiac Surgery.

Pediatr Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.

Pericardial effusion (PE) after pediatric cardiac surgery is common. Because of the lack of a uniform classification of the presence and severity of PE, we evaluated PE altering clinical management: clinically relevant PE. Risk factors for clinically relevant PE were studied. Read More

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December 2018
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Impact of Patient and Lesion Characteristics on Drug-Coated Balloon Angioplasty in the Femoropopliteal Artery: A Pooled Analysis of Four Randomized Controlled Multicenter Trials.

Cardiovasc Intervent Radiol 2018 Dec 11. Epub 2018 Dec 11.

Medical Scientific Affairs, B.Braun Melsungen AG, Berlin, Germany.

Objectives: The principal objective of this pooled analysis was to investigate various patient and lesion characteristics on late lumen loss (LLL) after drug-coated balloon (DCB) angioplasty.

Background: Four randomized controlled trials (THUNDER, FEMPAC, PACIFIER, CONSEQUENT) were pooled to investigate the influence of various patient and lesion characteristics on DCB angioplasty and on plain old balloon angioplasty (POBA) in patients with femoropopliteal artery disease.

Methods: Angiographic data from 355 patients were pooled to assess the impact of patient (demographics, cardiovascular risk factors, cardiovascular co-morbidities, Rutherford stages) and lesion-/procedure-related (location, occlusion, length, restenosis, calcification, subintimal crossing, post-dilatation, dissection, stenting) characteristics on LLL. Read More

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December 2018

Aerobic Variables for Prediction of Alpine Skiing Performance - A Novel Approach.

Sports Med Int Open 2018 Jul 7;2(4):E105-E112. Epub 2018 Sep 7.

Department of Community Medicine and Rehabilitation, Sports Medicine Unit, Umea University, Umeå, Sweden.

The aim of this study was to investigate the predictive power of aerobic test results and anthropometric variables on FIS-ranking of junior elite alpine skiers. Results from twenty-three male and female adolescent elite alpine skiers from two seasons were included in the multivariate statistical models. Physical work capacity was determined by V̇O2peak, blood lactate concentration ([HLa]b), and heart rate (HR) during ergometer cycling. Read More

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Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women.

Biomed Res Int 2018 14;2018:2032413. Epub 2018 Nov 14.

Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.

Ethnic differences in the level of thyroid hormones exist among individuals. The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy. To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill. Read More

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November 2018

Models for Predicting Time to Sputum Conversion Among Multi-Drug Resistant Tuberculosis Patients in Lagos, South-West Nigeria.

Front Public Health 2018 27;6:347. Epub 2018 Nov 27.

Department of Research and Innovation, University of Lagos, Lagos, Nigeria.

Multi-drug resistant tuberculosis (MDR-TB) develops due to problems such as irregular drug supply, poor drug quality, inappropriate prescription, and poor adherence to treatment. These factors allow the development and subsequent transmission of resistant strains of the pathogen. However, due to the chronic nature of MDR-TB, cure models allow us to investigate the covariates that are associated with the long-term effects of time-to-sputum conversion among multi-drug resistant (MDR-TB) tuberculosis individuals. Read More

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November 2018

Prognostic Role of MicroRNAs in Human Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.

Dis Markers 2018 21;2018:8309015. Epub 2018 Oct 21.

College of Health and Human Sciences, Charles Darwin University, Alan Walker Cancer Care Centre, Darwin, NT, Australia.

Background: MicroRNAs (miRNAs) have been found to play an important role in the development and outcomes for multiple human cancers. Their role as a prognostic biomarker in non-small-cell lung cancer (NSCLC) remains unclear. This meta-analysis aims to clarify the role of various miRNAs in the survival of NSCLC patients. Read More

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October 2018

Diagnostic Errors in Tuberculous Patients: A Multicenter Study from a Developing Country.

J Environ Public Health 2018 13;2018:1975931. Epub 2018 Nov 13.

Department of Statistics, Faculty of Mathematical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

Although there is still much to learn about the types of errors committed in health care and why they occur, enough is known today to recognize that a serious concern exists for patients. Tuberculosis (TB) is an infectious disease that is frequently subject to diagnostic errors. Missed or delayed diagnosis of TB can affect patients and community adversely. Read More

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November 2018

Labor augmentation during birth and later cognitive ability in young adulthood.

Clin Epidemiol 2018 26;10:1765-1772. Epub 2018 Nov 26.

Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark,

Purpose: Synthetic oxytocin for labor augmentation during birth has been linked to negative neurodevelopment effects in children. We examined whether maternal labor augmentation was associated with lower cognitive ability in young adulthoods.

Patients And Methods: We identified 330,107 individuals (96. Read More

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November 2018

First-line chemotherapy regimens for locally advanced and metastatic pancreatic adenocarcinoma: a Bayesian analysis.

Cancer Manag Res 2018 20;10:5965-5978. Epub 2018 Nov 20.

Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,

Background: Systemic chemotherapy is the standard treatment for locally advanced and metastatic pancreatic cancer, but there is no consensus on the optimum regimen. We aimed to compare and rank the locally advanced and metastatic pancreatic adenocarcinoma chemotherapy regimens evaluated in randomized controlled trials (RCTs) in the past 15 years.

Materials And Methods: PubMed, Embase, Cochrane Collaboration database, and ClinicalTrials. Read More

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November 2018

Dysfunctional phagocytosis capacity, granulocyte recruitment and inflammatory factor secretion of Kupffer cells in diabetes mellitus reversed by Lidocaine.

Diabetes Metab Syndr Obes 2018 26;11:827-834. Epub 2018 Nov 26.

Department of Gynaecology and Obstetrics, Beijing Key Laboratory of Cancer Therapeutic Vaccine, Beijing 100038, China,

Purpose: Kupffer cells (KCs) present dysfunctional immunity capacity among the diabetes mellitus patients. This study aims to investigate whether Lidocaine could reverse dysfunctions of KCs, in terms of phagocytosis, granulocyte recruitment and inflammatory mediator secretion.

Methods: db/db and C57BL/6 mice were employed to establish diabetic and nondiabetic models. Read More

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November 2018
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