11,149 results match your criteria Stasis Dermatitis


Combination of curcuma zedoary and kelp inhibits growth and metastasis of liver cancer in vivo and in vitro via reducing endogenous HS levels.

Food Funct 2018 Dec 10. Epub 2018 Dec 10.

Joint International Research Laboratory of Food & Medicine, College of Pharmacy, Henan University, Kaifeng, 475004 Henan, China.

The combination of traditional Chinese medicines can improve the efficacy of cancer treatment. Furthermore, the combination of the traditional Chinese medicine curcuma zedoary and kelp was used to enhance the effect of the dissipation of blood stasis in pediatrics during the Song Dynasty. Curcumenol and laminarin, the main components of curcuma zedoary and kelp, are also reported to have a wide range of biological activities. Read More

View Article
December 2018

The Interaction Effect between Blood Stasis Constitution and Atherosclerotic Factors on Cognitive Impairment in Elderly People.

Evid Based Complement Alternat Med 2018 11;2018:8914090. Epub 2018 Nov 11.

College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.

Objective: Blood stasis (BS) constitution represents a tendency to stagnation and positively associates with the severity of atherosclerosis. In this study, we have identified the interaction effect between BS constitution and atherosclerosis on cognitive impairment in the elderly people.

Methods: Eligible elderly people ≥65 years old who attended physical examination in the Mawei community of Fuzhou city during 2015 were enrolled in this study. Read More

View Article
November 2018

Elevated blood plasma levels of tissue factor-bearing extracellular vesicles in patients with atrial fibrillation.

Thromb Res 2018 Dec 2;173:141-150. Epub 2018 Dec 2.

Department of Clinical Biochemistry, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Søndre Skovvej 15, 9000 Aalborg, Denmark; Aalborg AF Study Group, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark; EVsearch.dk, Denmark. Electronic address:

Background: The risk of thrombus formation in the left atrial appendage (LAA) in patients with atrial fibrillation (AF) may result from blood stasis, local endocardial changes, and/or changed blood composition. Extracellular vesicles (EVs), especially subtypes exposing tissue factor (TF), have procoagulant capacity. We hypothesized that blood concentrations of TF-bearing EVs and other procoagulant biomarkers are elevated in AF patients, particularly in the LAA lumen. Read More

View Article
December 2018

Metabolomics study on promoting blood circulation and ameliorating blood stasis: investigating the mechanism of Angelica sinensis and its processed products.

Biomed Chromatogr 2018 Dec 5:e4457. Epub 2018 Dec 5.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, PR China.

Angelica sinensis (Danggui, DG) parched with alcohol (Jiu Danggui, JDG) and charred DG (CDG) were main processed products of DG, which were used to treat blood stasis syndrome (BSS). However, their therapeutic effect and mechanisms are still unclear. Based on a rats acute BSS model, the intervention effects of DG and its processed products (DGPPs) were evaluated by the hemorheology and coagulation function parameters. Read More

View Article
December 2018

Decreased platelet-to-lymphocyte ratio as predictor of thrombogenesis in nonvalvular atrial fibrillation.

Authors:
K Zuo X Yang

Herz 2018 Dec 5. Epub 2018 Dec 5.

Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, 100020, Beijing, China.

Background: Inflammation plays a key role in the progression of atrial fibrillation and its related prothrombotic state. The platelet-to-lymphocyte ratio (PLR) is an easily obtainable biomarker of inflammatory burden. Decreased left atrial appendage flow velocity (LAA-FV) reflects blood stasis, and left atrial strain is a manifestation of atrial remodeling. Read More

View Article
December 2018

Prisoners of war - host adaptation and its constraints on virus evolution.

Nat Rev Microbiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Zoology, University of Oxford, Oxford, UK.

Recent discoveries of contemporary genotypes of hepatitis B virus and parvovirus B19 in ancient human remains demonstrate that little genetic change has occurred in these viruses over 4,500-6,000 years. Endogenous viral elements in host genomes provide separate evidence that viruses similar to many major contemporary groups circulated 100 million years ago or earlier. In this Opinion article, we argue that the extraordinary conservation of virus genome sequences is best explained by a niche-filling model in which fitness optimization is rapidly achieved in their specific hosts. Read More

View Article
December 2018

Zhongfenggao protects brain microvascular endothelial cells from oxygen-glucose deprivation/reoxygenation-induced injury by angiogenesis.

Biol Pharm Bull 2018 Dec 5. Epub 2018 Dec 5.

Department of encephalopathy, Gansu Provincial Hospital of Traditional Chinese Medicine.

Zhongfenggao (ZFG) is prescribed for the treatment of cerebrovascular diseases in critical projects of the State Administration of Traditional Chinese Medicine. ZFG has been found to nourish qi, activate blood circulation, remove blood stasis, dredge collaterals, and strengthen the brain and mind. The present study investigated the effects of ZFG on oxygen-glucose deprivation/reoxygenation (OGD/R) induced injury to brain microvascular endothelial cells (BMECs), and the mechanisms underlying such effects. Read More

View Article
December 2018

Electroconvulsive Therapy While Receiving Oral Anticoagulation for Deep Venous Thrombosis: Report on Eight Cases and a Review of the Literature.

Psychosomatics 2018 Nov 7. Epub 2018 Nov 7.

University of Yamanashi, Faculty of Medicine, Department of Neuropsychiatry and Clinical Ethics, Yamanashi, Japan; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Background: Electroconvulsive therapy (ECT) is indicated for critical psychiatric conditions, which themselves constitute a risk for deep venous thrombosis (DVT) owing to prolonged immobility, dehydration, and venous stasis.

Objective: We describe challenging instances of ECT implementation while taking direct oral anticoagulants (DOACs).

Method: We report on 8 patients receiving DOACs for DVT who were successfully treated with ECT at the University of Yamanashi Hospital. Read More

View Article
November 2018

Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein.

Gastroenterol Res Pract 2018 31;2018:9829208. Epub 2018 Oct 31.

Necmettin Erbakan University, Meram School of Medicine, Department of Pathology, Turkey.

Aim: We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice.

Methods: A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. Read More

View Article
October 2018

The Epidemiology of Micro-Arteriovenous Fistulas in the Lower Legs.

Ann Vasc Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Objective: Patients presenting with edema, skin redness, pain, and itching in their lower legs are common and encountered often in daily practice. However, although commonly recognized diseases, such as deep venous thrombosis (DVT), stasis dermatitis due to varicose veins, lymphedema, and cellulitis, are diagnosed correctly in most cases, micro-arteriovenous fistulas (AVFs) may often be overlooked due to low awareness and rarity. This study was carried out to evaluate the prevalence of micro-AVF in patients presenting with foot skin symptoms. Read More

View Article
November 2018
3 Reads

A needle in a haystack: Mesozoic origin of parasitism in Strepsiptera revealed by first definite Cretaceous primary larva (Insecta).

PeerJ 2018 22;6:e5943. Epub 2018 Nov 22.

Institut für Zoologie und Evolutionsforschung, Spezielle Zoologie und Entomologie, Friedrich-Schiller Universität Jena, Jena, Germany.

Twisted winged insects (Strepsiptera) are a highly specialized small order of parasitic insects. Whether parasitism developed at an early or late stage in the evolution of the group was unknown. Here we record and describe the first Mesozoic strepsipteran primary larva embedded in Burmese amber (∼99 million years ago). Read More

View Article
November 2018

[Analysis on prescription rules of Chen Baogui's prescriptions for treating epigastric fullness based on data mining].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(20):4163-4168

Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China.

To summary and analyze the prescription rules of Professor Chen Baogui, a famous traditional Chinese medicine (TCM) doctor, for treating epigastric fullness. Professor Chen Baogui's prescriptions for treating epigastric fullness were collected and the treatment data were input into traditional Chinese medicine inheritance support system (TCMISS) to analyze the rules of the prescriptions by using data mining methods. Based on the screened 214 cases, the treatment experience of Professor Chen Baogui for treating epigastric fullness was summarized and analyzed. Read More

View Article
October 2018

[Transport characteristics of Shuxiong prescription across Caco-2 cell monolayer model].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(20):4132-4137

Third Military Medical University, Chongqing 400038, China.

Shuxiong prescription (Notoginseng Radix et Rhizoma, Chuanxiong Rhizome and Carthami Flos) has the function of activating blood circulation to dissipate blood stasis, activating meridians to stop pain. This paper was mainly aimed to discuss the transport characteristics of Shuxiong prescription across Caco-2 cell monolayer. Safe concentration range of Shuxiong prescription against Caco-2 cell monolayer model was determined by MTT assay. Read More

View Article
October 2018

Adjuvant Lymphatic Osteopathic Manipulative Treatment in Patients With Lower-Extremity Ulcers: Effects on Wound Healing and Edema.

J Am Osteopath Assoc 2018 Dec;118(12):798-805

Context: In 2012, the US wound registry estimated that the cost of managing chronic wounds in the United States exceeded $50 billion. A large percentage of these wounds are venous stasis ulcers of the lower extremity. Evidence suggests that adjuvant osteopathic manipulative treatment (OMT) may provide a benefit by reducing edema and subsequent healing times in venous stasis ulcers of the lower extremity. Read More

View Article
December 2018

Assessment of Intermingled Phlegm and Blood Stasis Syndrome in Coronary Heart Disease: Development of a Diagnostic Scale.

Evid Based Complement Alternat Med 2018 24;2018:4683431. Epub 2018 Oct 24.

School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Background: Intermingled Phlegm and Blood Stasis Syndrome (IPBSS) is a common feature in patients with coronary heart disease (CHD). In clinical practice, the diagnostic agreement of clinical doctor of Chinese Medicine (CM) is poor. We previously developed a IPBSS diagnostic scale for use by general practitioner. Read More

View Article
October 2018

Effectiveness and safety of micronized purified flavonoid fraction for the treatment of concomitant varicose veins of the pelvis and lower extremities.

Curr Med Res Opin 2018 Nov 23:1-16. Epub 2018 Nov 23.

b City Clinical Hospital №1 named after N.I. Pirogov , Moscow , Russia.

Objective: Concomitant varicose veins of the pelvis (VVP) and lower extremities (VVLE) frequently coexist. This study evaluated the effectiveness and safety of micronized purified flavonoid fraction (MPFF) in the treatment of patients with both conditions.

Methods: Female outpatients with concomitant VVP and VVLE received MPFF 1000 mg once daily for 2 months (Group 1), or 1000 mg twice daily for 1 month followed by 1000 mg once daily for 1 month (Group 2), based on pelvic pain intensity. Read More

View Article
November 2018
1 Read

Endovenous Photocoagulation Using a Diode Laser for Complicated Varicose Veins Related to Stasis Ulcers.

Ann Plast Surg 2019 Jan;82(1S Suppl 1):S103-S107

Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University.

Background: The objective of this study was to assess the efficacy and safety of endovenous laser photocoagulation (EVLP) at a wavelength of 810 nm for treating complicated venous insufficiency associated with venous ulcers.

Materials And Methods: A retrospective review of 110 patients with 180 legs having chronic venous insufficiencies associated with varicose veins treated over an 8-year period was conducted. Patients ranged from 16 to 80 years of age and included 85 women and 25 men. Read More

View Article
January 2019
1 Read

Utility of Skin Biopsy and Culture in the Diagnosis and Classification of Chronic Ulcers: A Single-Institution, Retrospective Study.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Department of Pathology, University of Washington, Seattle, WA.

In the United States, chronic ulcers affect 6.5 million people, with a cost of ≈$20 million annually. The most common etiology of chronic ulcers in the United States is venous stasis, followed by arterial insufficiency and neuropathic ulcers. Read More

View Article
November 2018
6 Reads

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway.

Front Immunol 2018 30;9:2484. Epub 2018 Oct 30.

Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). While the etiology of MS is still largely unknown, scientists believe that the interaction of several endogenous and exogenous factors may be involved in this disease. Epidemiologists have seen an increased prevalence of MS in countries at high latitudes, where the sunlight is limited and where the populations have vitamin D deficiency and high melatonin levels. Read More

View Article
October 2018
7 Reads

Visualizing and quantifying flow stasis in abdominal aortic aneurysms in men using 4D flow MRI.

Magn Reson Imaging 2018 Nov 13;57:103-110. Epub 2018 Nov 13.

Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.

Purpose: To examine methods for visualizing and quantifying flow stasis in abdominal aortic aneurysms (AAA) using 4D Flow MRI.

Methods: Three methods were investigated: conventional volumetric residence time (VRT), mean velocity analysis (MVA), and particle travel distance analysis (TDA). First, ideal 4D Flow MRI data was generated using numerical simulations and used as a platform to explore the effects of noise and background phase-offset errors, both of which are common 4D Flow MRI artifacts. Read More

View Article
November 2018
3 Reads

Usefulness of Topically Applied Sensors to Assess the Quality of 18F-FDG Injections and Validation Against Dynamic Positron Emission Tomography (PET) Images.

Front Med (Lausanne) 2018 1;5:303. Epub 2018 Nov 1.

ASTAR-NUS Clinical Imaging Research Centre (A*STAR), Singapore, Singapore.

Infiltrations of 18F-fluorodeoxyglucose (FDG) injections affect positron emission tomography/computed tomography (PET/CT) image quality and quantification. A device using scintillation sensors (Lucerno Dynamics, Cary, NC) provides dynamic measurements acquired during FDG uptake to identify and characterize radioactivity near the injection site prior to patient imaging. Our aim was to compare sensor measurements against dynamic PET image acquisition, our proposed reference in assessing injection quality during the uptake period. Read More

View Article
November 2018
2 Reads

The coronary circulation in acute myocardial ischaemia/reperfusion injury - a target for cardioprotection.

Cardiovasc Res 2018 Nov 14. Epub 2018 Nov 14.

Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.

The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary occlusion, and this occlusion must be removed to induce reperfusion. However, ischaemia and reperfusion cause damage not only in cardiomyocytes but also in the coronary circulation, including microembolisation of debris and release of soluble factors from the culprit lesion, impairment of endothelial integrity with subsequently increased permeability and oedema formation, platelet activation and leukocyte adherence, erythrocyte stasis, a shift from vasodilation to vasoconstriction, and ultimately structural damage to the capillaries with eventual no-reflow, microvascular obstruction and intramyocardial haemorrhage. Read More

View Article
November 2018
6 Reads

Chemical Profiling of Xueshuan Xinmaining Tablet by HPLC and UPLC-ESI-Q-TOF/MS.

Evid Based Complement Alternat Med 2018 21;2018:2781597. Epub 2018 Oct 21.

Jilin Huakang Stock Ltd., Company of Medicines, Dunhua 133700, China.

Xueshuan Xinmaining Tablet (XXT) is a widely used traditional Chinese medicine for the treatment of stroke, chest pain, coronary heart disease, and angina pectoris caused by blood stasis. Having a multiple-component preparation, it is still far from meeting the requirements of modernization and standardization because its detailed chemical basis and action mechanism have not been clarified. In this work, the different batches of XXT samples were analyzed by HPLC and the typical sample was analyzed by UPLC-ESI-Q-TOF/MS to understand its chemical profiling. Read More

View Article
October 2018
4 Reads

Aqueous extract of Dipsacus asperoides suppresses lipopolysaccharide-stimulated inflammatory responses by inhibiting the ERK1/2 signaling pathway in RAW 264.7 macrophages.

J Ethnopharmacol 2018 Nov 8;231:253-261. Epub 2018 Nov 8.

College of Korean Medicine, Dongguk University, Goyang 10326, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Dipsaci Radix, which is the dried root of Dipsacus asperoides C. Y. Cheng and T. Read More

View Article
November 2018
4 Reads

Achyranthes bidentata polypeptide k improves long-term neurological outcomes through reducing downstream microvascular thrombosis in experimental ischemic stroke.

Brain Res 2018 Nov 8. Epub 2018 Nov 8.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China. Electronic address:

Achyranthes bidentata Bl. (A. bidentata) occupies an important position in traditional Chinese medicine owing to the property of promoting the circulation of blood and removing stasis. Read More

View Article
November 2018
6 Reads

The Multiple Causes of Stroke in Atrial Fibrillation: Thinking Broadly.

Can J Cardiol 2018 Nov 30;34(11):1503-1511. Epub 2018 Aug 30.

Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Atrial fibrillation (AF) is numerically the most important risk factor for stroke. It is well established that patients with AF have a 5-fold increased risk of stroke relative to those without and that anticoagulation reduces the risk of stroke by approximately two-thirds. Definitively attributing the mechanism of an individual stroke to AF is more problematic, however. Read More

View Article
November 2018
4 Reads

Spectrum of Voriconazole-Induced Periostitis With Review of the Differential Diagnosis.

AJR Am J Roentgenol 2018 Nov 7:1-9. Epub 2018 Nov 7.

1 Department of Radiology, University of Illinois College of Medicine, 1740 W Taylor St, Rm. 2483 (MC 931), Chicago, IL 60612.

Objective: Voriconazole is an antifungal medication used primarily for the treatment of Candida and Aspergillus infections. A fairly newly described side effect of long-term voriconazole use is periostitis. The purpose of this article is to describe the main differential consideration-hypertrophic osteoarthropathy-and other differential diagnoses, including venous stasis, thyroid acropachy, and hypervitaminosis A. Read More

View Article
November 2018
8 Reads

Healthy roots and leaves: comparative genome structure of horseradish and watercress.

Plant Physiol 2018 Nov 5. Epub 2018 Nov 5.

CEITEC - Central European Institute of Technology, Masaryk University CITY: Brno POSTAL_CODE: 62500 Czech Republic [CZ]

Horseradish and watercress are economically important cruciferous vegetable species with limited genomic resources. We used comparative chromosome painting to identify the extent of chromosomal collinearity between horseradish (Armoracia rusticana) and watercress (Nasturtium officinale), and to reconstruct the origin and evolution of the two tetraploid genomes (2n = 4x = 32). Our results show that horseradish and watercress genomes originated from a common ancestral (n = 8) genome, structurally resembling the Ancestral Crucifer Karyotype (n = 8), which, however, contained two unique translocation chromosomes (AK6/8 and AK8/6). Read More

View Article
November 2018
3 Reads

Lagopsis supina exerts its diuretic effect via inhibition of aquaporin-1, 2 and 3 expression in a rat model of traumatic blood stasis.

J Ethnopharmacol 2018 Oct 27. Epub 2018 Oct 27.

Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address:

Ethnopharmacological Relevance: Lagopsis supina has been used as a traditional medicinal herb for centuries in China. In folk medicine, it is used for promoting blood circulation and removing blood stasis (PBCRBS), anti-inflammatory and diuresis activities. Modern pharmacological investigation have shown that L. Read More

View Article
October 2018
4 Reads
3.000 Impact Factor

Assessment of oropharyngeal swallowing dysfunction in myasthenia gravis patients presenting with difficulty in swallowing.

Auris Nasus Larynx 2018 Nov 1. Epub 2018 Nov 1.

Department of Otolaryngology Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto, Japan.

Objective: To examine the correlation between the results of a clinical neurological evaluation and swallowing dysfunction in myasthenia gravis (MG) patients who presented with difficulty in swallowing and underwent videofluorographic (VF) and fiber-optic endoscopic (FE) evaluation.

Methods: The swallowing studies of 13MG patients with difficulty in swallowing seen at the Department of Neurology from June 2016 to April 2018 were reviewed. The assessment parameters on VF and FE examination were as follows: swallowing initiation, bolus stasis at the pyriform sinus (PS) and vallecula (VC), and the degree of aspiration. Read More

View Article
November 2018
3 Reads

Intestinal ischemia secondary to superior mesenteric venous thrombosis-A case report.

Int J Surg Case Rep 2018 Oct 29;53:96-98. Epub 2018 Oct 29.

General Surgical Department, Caboolture Hospital, Caboolture, QLD 4510, Australia.

Introduction: Acute mesenteric venous thrombosis is a rare but potentially fatal condition with superior mesenteric vein being the most common site of thrombosis development [1]. It is more common in patients with underlying disorders which cause disruptions to Virchow's Triad of hypercoagulability, stasis and endothelial injury. The disease is often associated with intestinal ischemia in its acute form, further complicating its management. Read More

View Article
October 2018
6 Reads

X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family.

Sci Rep 2018 Nov 2;8(1):16280. Epub 2018 Nov 2.

Department of OBGYN and Reproductive Sciences, Magee-Womens Research Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

We performed whole exome sequencing to identify an unknown genetic cause of azoospermia and male infertility in a large Pakistani family. Three infertile males were subjected to semen analysis, hormone testing, testicular histology, ultrasonography, karyotyping, Y-chromosome microdeletion and CFTR testing. The clinical testing suggested a diagnosis of obstructive azoospermia (OA). Read More

View Article
November 2018
3 Reads

The prothrombotic state in atrial fibrillation: pathophysiological and management implications.

Cardiovasc Res 2018 Nov 2. Epub 2018 Nov 2.

Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom.

Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia, and is associated with significant morbidity and mortality. There is plenty of evidence available to support the presence of a prothrombotic or hypercoagulable state in AF, but the contributory factors are multifactorial and cannot simply be explained by blood stasis.Abnormal changes in atrial wall (anatomical and structural, as 'vessel wall abnormalities'), the presence of spontaneous echo contrast to signify abnormal changes in flow and stasis ('flow abnormalities") and abnormal changes in coagulation, platelet and other pathophysiologic pathways ('abnormalities of blood constituents') are well documented in AF. Read More

View Article
November 2018

Rethinking Living Fossils.

Bioscience 2018 Oct 15;68(10):760-770. Epub 2018 Aug 15.

Department of Philosophy and the Minnesota Center for Philosophy of Science, University of Minnesota, Minneapolis.

Biologists would be mistaken if they relegated living fossils to paleontological inquiry or assumed that the concept is dead. It is now used to describe entities ranging from viruses to higher taxa, despite recent warnings of misleading inferences. Current work on character evolution illustrates how analyzing living fossils and stasis in terms of parts (characters) and wholes (e. Read More

View Article
October 2018

Obstructive sleep apnoea and venous thromboembolism: pathophysiological links and clinical implications.

Eur Respir J 2018 Nov 1. Epub 2018 Nov 1.

Pneumology Department, Hospital Universitario y Politécnico la Fe de Valencia, Spain.

Obstructive sleep apnoea (OSA) and pulmonary embolism (PE) remain a major health issue worldwide. Data from pathophysiological studies suggest that both intermittent hypoxia and sleep fragmentation are associated with increased blood coagulability, endothelial dysfunction and venous stasis. There is growing evidence that OSA is potentially prevalent and a risk factor for PE. Read More

View Article
November 2018
1 Read

The Impact of Fructo-Oligosaccharides on Gut Permeability and Inflammatory Responses in the Cecal Mucosa Quite Differs between Rats Fed Semi-Purified and Non-Purified Diets.

J Nutr Sci Vitaminol (Tokyo) 2018 ;64(5):357-366

College of Agriculture, Academic Institute, Shizuoka University.

The effects of fructo-oligosaccharides (FOS) on gut-barrier function are still controversial in human and animal studies. Diet conditions would be a major factor for the controversy in animal studies. We fed rats a semi-purified (SP) or a non-purified diet (NP) with or without FOS (60 g/kg diet) for 9 (experiment 1) or 10 d (experiment 2). Read More

View Article
January 2018
1 Read

Ceftaroline fosamil doses and breakpoints for Staphylococcus aureus in complicated skin and soft tissue infections.

J Antimicrob Chemother 2018 Oct 31. Epub 2018 Oct 31.

Allergan Inc., 5 Giralda Farms, Madison, NJ, USA.

Objectives: To describe the pharmacokinetic/pharmacodynamic (PK/PD) modelling and microbiological data that were used to support the recent European approval of ceftaroline fosamil 600 mg q8h by 2 h intravenous (iv) infusion for patients with complicated skin and soft tissue infections (cSSTIs) caused by Staphylococcus aureus with ceftaroline MICs of 2 or 4 mg/L, and the associated EUCAST MIC breakpoint update for q8h dosing (intermediate = 2 mg/L and resistant >2 mg/L).

Methods: A population PK model for ceftaroline and ceftaroline fosamil was developed using PK data from 21 clinical studies. The final model was used to simulate PTA in patients with cSSTI receiving ceftaroline fosamil 600 mg q12h by 1 h iv infusion or 600 mg q8h by 2 h iv infusion. Read More

View Article
October 2018
1 Read

Late-onset extensive haematoma mimicking cellulitis.

Int Wound J 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, Korea University College of Medicine, Seoul, Republic of Korea.

Cellulitis is a microbial infection of the deep dermis and the subcutaneous tissue. Several non-infectious disorders, such as contact dermatitis, insect bites, stasis dermatitis, and lipodermatosclerosis, masquerade as infectious cellulitis. There are no specific criteria for the diagnosis of cellulitis; thus, it is challenging to correctly diagnose true cellulitis. Read More

View Article
October 2018
1 Read

Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent.

J Nat Med 2018 Oct 29. Epub 2018 Oct 29.

Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.

Oxidative stress due to the overproduction of reactive oxygen species plays an important role in the pathogenesis of various diseases. In the present study, we comprehensively evaluated the antioxidant activities of 147 oral formulations of Japanese traditional herbal medicines (Kampo medicines), representing the entire panel of oral Kampo medicines listed in the Japanese National Health Insurance Drug List, using in vitro radical scavenging assays, including the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity assay, the superoxide anion scavenging activity assay, and the oxygen radical absorption capacity assay. Three of the formulations tested, namely, Tsudosan, Daisaikoto, and Masiningan, showed the most potent in vitro antioxidant activities and were selected for further investigation of their intracellular and in vivo antioxidant effects. Read More

View Article
October 2018
6 Reads
1.450 Impact Factor

Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study.

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

View Article
May 2018
1 Read

Use of Translational PK/PD Infection Models to Understand Impact of Neutropenia on Efficacy of Tedizolid Phosphate.

Antimicrob Agents Chemother 2018 Oct 29. Epub 2018 Oct 29.

Merck & Co. Inc., Kenilworth, NJ, USA

Tedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated improved potency and pharmacokinetics-pharmacodynamics (PK/PD) vs linezolid. Subsequent studies showed that the efficacy of tedizolid was enhanced in immune competent (IC) compared with neutropenic (IS) mice, with stasis at clinically relevant doses being achieved only in the presence of granulocytes. Read More

View Article
October 2018
11 Reads

Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection.

Evid Based Complement Alternat Med 2018 2;2018:7482593. Epub 2018 Oct 2.

Department of Integrative Chinese and Western Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.

The aim of this study is to investigate traditional Chinese medicine syndrome (TCMS) patterns and their association with hepatitis B surface antigen (HBsAg) levels during the natural history of chronic hepatitis B virus infection (CHB). Patients were categorized according to the phase of CHB, as follows: immune tolerance (ITP); immune clearance (ICP); low or nonreplication (LRP); reactivation (RAP); hepatic cirrhosis (HC); and primary liver cancer (PLC). TCMS patterns were classified among the following types: spleen-kidney deficiency (SKD); liver-qi depression (LQD); damp-heat in liver-gallbladder (LGDH); liver-kidney deficiency (LKD); and blood stasis blocking collateral (BSBC). Read More

View Article
October 2018
1 Read

Phylogenetic trends and environmental correlates of nuclear genome size variation in Helianthus sunflowers.

New Phytol 2018 Oct 6. Epub 2018 Oct 6.

Division of Biology, Kansas State University, Manhattan, KS, 66506, USA.

Flowering plants serve as a powerful model for studying the evolution of nuclear genome size (GS) given the tremendous GS variation that exists both within and across angiosperm lineages. Helianthus sunflowers consist of c. 50 species native to North America that occupy diverse habitats and vary in ploidy level. Read More

View Article
October 2018
2 Reads

Diversification, adaptation, and community assembly of the American oaks (Quercus), a model clade for integrating ecology and evolution.

New Phytol 2018 Oct 23. Epub 2018 Oct 23.

Department of Ecology, Evolution and Behavior, University of Minnesota, Saint Paul, MN, 55108, USA.

Contents Summary I. Model clades for the study and integration of ecology and evolution II. Oaks: an important model clade III. Read More

View Article
October 2018
13 Reads

Validation of a LC/MSMS method for simultaneous quantification of 9 nucleotides in biological matrices.

Talanta 2019 Feb 3;193:206-214. Epub 2018 Oct 3.

RD3 - Pharmacognosy, Bioanalysis and Drug Development, Faculty of Pharmacy, Université Libre de Bruxelles, Campus Plaine CP 205/05, Boulevard du Triomphe, B-1050 Bruxelles, Belgium; Analytical Platform of the Faculty of Pharmacy, Université Libre de Bruxelles, Campus Plaine CP 205/05, Boulevard du Triomphe, B-1050 Bruxelles, Belgium.

Nucleotides play a role in inflammation processes: cAMP and cGMP in the endothelial barrier function, ADP in platelet aggregation, ATP and UTP in vasodilatation and/or vasoconstriction of blood vessels, UDP in macrophages activation. The aim of this study is to develop and validate a LC/MS-MS method able to quantify simultaneously nine nucleotides (AMP, cAMP, ADP, ATP, GMP, cGMP, UMP, UDP and UTP) in biological matrixes (cells and plasma). The method we developed, has lower LOQ's than others and has the main advantage to quantify all nucleotides within one single injection in less than 10 min. Read More

View Article
February 2019
5 Reads

Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus.

Clinics (Sao Paulo) 2018 Oct 18;73:e332. Epub 2018 Oct 18.

Department of Surgery, University of Pittsburgh School of Medicine, PA, USA.

Objectives: Several compounds characterized by an olefin linkage conjugated to a carbonyl group have anti-inflammatory properties. The diuretic ethacrynic acid (EA) is a compound of this type. Herein, we tested the hypothesis that ethacrynic acid can modulate the development of ileus after bowel manipulation. Read More

View Article
October 2018
1 Read

Atlantoaxial Subluxation Secondary to Unstable Os Odontoideum in a Patient With Arrested Hydrocephalus Due to Congenital Aqueductal Stenosis: A Case Report.

Int J Spine Surg 2018 Oct 15;12(5):549-556. Epub 2018 Oct 15.

Department of Spinal Surgery, Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Tehran, Iran.

Background: In a small percentage of children born with congenital hydrocephalus, enlargement of the head and the presence of ventriculomegaly may halt and ultimately stabilize the condition designated as arrested hydrocephalus. Arrested hydrocephalus in children is typically due to congenital aqueduct stenosis, which can be described appropriately as a stasis existing within the channel between the third and fourth ventricles. Os odontoideum (OO) is an uncommonly occurring pathology at the craniovertebral junction. Read More

View Article
October 2018
7 Reads

[Atheromatous coronary ectasia].

Pan Afr Med J 2018 12;30:111. Epub 2018 Jun 12.

Service de Cardiologie, Hôpital Militaire Avicenne, Université Cadi Ayyad, Faculté de Médecine et de Pharmacie, Marrakech, Maroc.

Coronary ectasias are relatively rare and poorly known pathologies. In adults they are caused most often by atheromas. These anomalies can expose to intracoronary thrombotic risk due to blood stasis. Read More

View Article
November 2018
6 Reads