296 results match your criteria Stasis Dermatitis


Allergic Contact Sensitization in Healthy Skin Differs from Sensitization in Chronic Dermatitis: Atopic, Occupational Wet Work, and Stasis Dermatitis.

Authors:
Susan T Nedorost

Dermatol Clin 2020 Jul 17;38(3):301-308. Epub 2020 Apr 17.

University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Lakeside Suite 6223, Cleveland, OH 44106, USA. Electronic address:

The duration of cutaneous inflammation preceding sensitization influences the resulting allergic response; the innate immune system instructs the adaptive immune response. Potent allergens that function as their own irritant cause classic T helper cell type 1 skewed dermatitis. Examples include poison ivy, epoxy resin, and methylchloroisothiazolinone. Read More

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http://dx.doi.org/10.1016/j.det.2020.02.006DOI Listing

Clinical Psoriasiform Dermatitis Following Dupilumab Use for Autoeczematization Secondary to Chronic Stasis Dermatitis.

Cureus 2020 Apr 25;12(4):e7831. Epub 2020 Apr 25.

Dermatology, University Hospitals Cleveland Medical Center, Cleveland, USA.

T helper 2 (Th2) and T helper 1 (Th1) mediated immune processes lie on a spectrum. Autoeczematization secondary to chronic stasis dermatitis may fall on the Th2 side of the spectrum due to skin stretch and chronic barrier dysfunction, supporting a primary Th2 response to self-antigen. In our patient, we posited that dupilumab would benefit autoeczematization secondary to chronic stasis dermatitis given its efficacy in atopic dermatitis, a Th2-mediated immune process. Read More

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http://dx.doi.org/10.7759/cureus.7831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249757PMC

Update of the SFMV (French society of vascular medicine) guidelines on the conditions and safety measures necessary for thermal ablation of the saphenous veins and proposals for unresolved issues.

J Med Vasc 2020 May 15;45(3):130-146. Epub 2020 Apr 15.

Unité de Médecine Vasculaire, Centre Hospitalier Universitaire de Rennes, 35000 Rennes, France.

Venous insufficiency is a very common disease affecting about 25% of the French population (if we combine all stages of its progression). It is a complex disease and its aetiology has not yet been fully elucidated. Some of its causes are well known, such as valvular dysfunction, vein wall defect, and the suctioning effect common to all varicose veins. Read More

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http://dx.doi.org/10.1016/j.jdmv.2020.03.005DOI Listing

Stasis Mucinosis: Insights Into Euthyroid Localized Mucinosis.

Wounds 2019 Sep;31(9):E58-E560

Department of Dermatology, Miller School of Medicine, University of Miami, Miami, FL.

Introduction: Stasis mucinosis and obesity-associated lymphedematous mucinosis (OALM) have been described as 2 discrete diagnostic entities.

Case Report: A morbidly obese African American man in his late 60s presented to the emergency room with a 3-month history of swelling of both lower extremities and secondary changes suggestive of lymphedema and venous dermatitis. On physical examination, the patient had severe edema with multiple raised areas of verruciform skin changes and varicosities, diffuse induration, erythema, and scaling. Read More

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September 2019

Gemcitabine-induced pseudocellulitis: a case report and review of the literature.

Curr Oncol 2019 10 1;26(5):e703-e706. Epub 2019 Oct 1.

Schulich School of Medicine and Dentistry, London Regional Cancer Program, London, ON.

Gemcitabine is a chemotherapeutic agent used in a wide variety of solid tumours. Known side effects include a dose-limiting myelosuppressive toxicity, mild rash, and radiation-dependent dermatitis. Rarely, localized inflammation in the form of pseudocellulitis has also been observed. Read More

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http://dx.doi.org/10.3747/co.26.5007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821114PMC
October 2019

Effectiveness of iliac vein stenting combined with high ligation/endovenous laser treatment of the great saphenous veins in patients with Clinical, Etiology, Anatomy, Pathophysiology class 4 to 6 chronic venous disease.

J Vasc Surg Venous Lymphat Disord 2020 Jan 5;8(1):74-83. Epub 2019 Nov 5.

Department of Vascular Surgery, Zhongshan Hospital, Affiliated to Fudan University, Shanghai, People's Republic of China; Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Affiliated to Fudan University, Shanghai, People's Republic of China. Electronic address:

Background: Lower limb chronic venous disease (CVD), resulting from iliac vein compression syndrome (IVCS), manifests as a series of symptoms ranging from varicose veins to venous ulcerations. Stent implantation has been considered an effective treatment method; however, the management of CVD has rarely been reported. In the present study, we evaluated the treatment and outcomes of patients with CVD. Read More

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http://dx.doi.org/10.1016/j.jvsv.2019.08.009DOI Listing
January 2020
4 Reads

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases.

Authors:
Chao-Hsing Kao

Int Wound J 2020 Feb 29;17(1):158-166. Epub 2019 Oct 29.

Dermatologic Clinic, Taiwan.

Treating chronic skin wounds in patients with diabetes, bed sores, or stasis dermatitis is typically a time-consuming and costly process, and the outcome is not always promising. Concentrated growth factor (CGF) obtained from the autologous venous blood of patients via fractional centrifugation is employed for producing a CGF gel or membrane that can be applied to expedite self-regeneration of skin wounds. In this case report, we presented the results from 18 patients with chronic skin wounds treated with a CGF gel or membrane produced from autologous venous blood. Read More

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http://dx.doi.org/10.1111/iwj.13250DOI Listing
February 2020
1 Read

Mechanisms of Itch in Stasis Dermatitis: Significant Role of IL-31 from Macrophages.

J Invest Dermatol 2020 Apr 15;140(4):850-859.e3. Epub 2019 Oct 15.

Miami Itch Center, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA. Electronic address:

Stasis dermatitis (SD) is a common disease in the elderly population, with pruritus being one of the troublesome symptoms. However, there are few therapeutic modalities available for SD-associated itch because little is known about its pathophysiological mechanism. Therefore, we sought to investigate the mediators of itch in SD using an immunofluorescence study on patient lesions focusing on IL-31. Read More

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http://dx.doi.org/10.1016/j.jid.2019.09.012DOI Listing
April 2020
2 Reads

Contact Dermatitis in the Elderly: Predisposing Factors, Diagnosis, and Management.

Drugs Aging 2019 05;36(5):411-417

Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.

Increased aging of the general population is a well-known fact with serious effects on health systems worldwide. Skin aging involves various immunological and structural changes that increase the risk of numerous skin diseases such as contact dermatitis. Contact dermatitis is characterized by an inflammation of the skin caused by an interaction between the skin and external agents and is divided into irritant and allergic contact dermatitis. Read More

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http://dx.doi.org/10.1007/s40266-019-00641-4DOI Listing
May 2019
14 Reads

Cardiovascular Disease: Chronic Venous Insufficiency and Varicose Veins.

FP Essent 2019 Apr;479:16-20

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Chronic venous insufficiency (CVI) results from long-term venous hypertension in the legs caused by venous obstruction, venous valve incompetency, muscle pump dysfunction, or a combination of these. CVI occurs in 9.4% of men and 6. Read More

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April 2019
24 Reads

Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient.

Endocrinol Diabetes Metab Case Rep 2019 Mar 14;2019. Epub 2019 Mar 14.

Wolfson Diabetes Centre, Addenbrooke's Hospital Cambridge, Cambridge, UK.

Necrobiosis lipoidica diabeticorum (NLD) is a chronic granulomatous dermatitis generally involving the anterior aspect of the shin, that arises in 0.3-1.2% of patients with diabetes mellitus (1). Read More

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http://dx.doi.org/10.1530/EDM-19-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432984PMC
March 2019
34 Reads

Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies.

Contact Dermatitis 2019 Jun 10;80(6):354-358. Epub 2019 Apr 10.

Division of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, Canada.

Background: Polysensitivity is defined as three or more positive patch test reactions. The role of filaggrin gene (FLG) loss-of-function mutations in patients with polysensitivity has not been studied when barrier bypass and possible preceding barrier damage have been excluded.

Objectives: To determine whether FLG loss of function mutations play a role in patients with multiple contact sensitivities when barrier bypass is excluded. Read More

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http://dx.doi.org/10.1111/cod.13268DOI Listing
June 2019
3 Reads

Pattern of Dermatological Disease Encountered in a Hematology Ward: A Retrospective Analysis of Dermatology Consultation in a Hematology Ward in a Tertiary Care Center in Saudi Arabia.

Dermatol Res Pract 2019 13;2019:9891270. Epub 2019 Jan 13.

Intermediate Care Unit, King Abdulaziz Medical City (KAMC), National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia.

Skin manifestations are common in hematology ward patients and can result from infection, malignancy, or chemotherapy. The purpose of this study was to identify the most common dermatological problems encountered in the adult hematology ward at King Abdullah Specialist Children Hospital (KASCH). This was retrospective chart review of 78 dermatology consultations based on electronic health records for all inpatients in hematology wards at KASCH between January 2016 and December 2017. Read More

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http://dx.doi.org/10.1155/2019/9891270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348816PMC
January 2019
32 Reads

Development and implementation of an order set to improve value of care for patients with severe stasis dermatitis.

J Am Acad Dermatol 2019 03 25;80(3):815-817. Epub 2018 Oct 25.

Case Western Reserve University School of Medicine, Cleveland, Ohio; Johns Hopkins, Baltimore, Maryland.

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183280
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http://dx.doi.org/10.1016/j.jaad.2018.10.034DOI Listing
March 2019
34 Reads

The Epidemiology of Micro-arteriovenous Fistulas in the Lower Legs.

Ann Vasc Surg 2019 Apr 28;56:29-35. Epub 2018 Nov 28.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Patients presenting with edema, skin redness, pain, and itching in their lower legs are common and encountered often in daily practice. However, although commonly recognized diseases such as deep venous thrombosis, stasis dermatitis due to varicose veins, lymphedema, and cellulitis are diagnosed correctly in most cases, micro-arteriovenous fistulas (AVFs) may often be overlooked due to low awareness and rarity. This study was carried out to evaluate the prevalence of micro-AVF in patients presenting with foot skin symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096183088
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http://dx.doi.org/10.1016/j.avsg.2018.09.008DOI Listing
April 2019
29 Reads

Late-onset extensive haematoma mimicking cellulitis.

Int Wound J 2019 Feb 31;16(1):297-299. Epub 2018 Oct 31.

Department of Dermatology, Korea University College of Medicine, Seoul, Republic of Korea.

Cellulitis is a microbial infection of the deep dermis and the subcutaneous tissue. Several non-infectious disorders, such as contact dermatitis, insect bites, stasis dermatitis, and lipodermatosclerosis, masquerade as infectious cellulitis. There are no specific criteria for the diagnosis of cellulitis; thus, it is challenging to correctly diagnose true cellulitis. Read More

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http://dx.doi.org/10.1111/iwj.13014DOI Listing
February 2019
6 Reads
2.023 Impact Factor

Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study.

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

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http://dx.doi.org/10.14744/nci.2017.68553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191549PMC
May 2018
10 Reads

Sweat in the pathogenesis of atopic dermatitis.

Allergol Int 2018 Oct 3;67(4):455-459. Epub 2018 Aug 3.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

Sweat is a transparent hypotonic body fluid made from eccrine sweat glands. Various ingredients contained in sweat are involved in a broad sense in skin homeostasis including temperature regulation, skin moisture, and immune functions. Thus, sweat plays a major role in maintaining skin homeostasis. Read More

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http://dx.doi.org/10.1016/j.alit.2018.06.003DOI Listing
October 2018
10 Reads

The rainbow pattern in dermoscopy: A zoom on nonkaposi sarcoma skin diseases.

Biomed J 2018 06 11;41(3):209-210. Epub 2018 Jul 11.

Department of Dermatology, Hassan II University Hospital of Fez, Fez, Morocco.

The rainbow pattern is currently a subject of debate, it is considered the specific dermoscopic pattern of Kaposi sarcoma. We present in this research correspondence a review of 700 dermoscopic figures of different biopsy-proven skin diseases in our department of dermatology of the Hospital Hassan II of Fez. All the lesions were localized to the limbs except for one lesion of atrophic scar that was localized on the left shoulder. Read More

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http://dx.doi.org/10.1016/j.bj.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138765PMC
June 2018
34 Reads

Assessment of a topical product based on polysulfated galactosaminoglycan as an adjuvant in the treatment of acute STP and stasis dermo-hypodermitis.

Minerva Med 2018 Aug 24;109(4):276-279. Epub 2018 Apr 24.

Gemelli Policlinic, Rome, Italy -

Background: Superficial thrombophlebitis (STP) is a relatively frequent pathology characterized by possible extension to the deep venous circulation, with notable local inflammatory reaction which is treated by subcutaneous administration of Fondaparinux. Stasis dermo-hypodermitis is characterized by cutaneous hyperpigmentation and eczema, treatment for which consists of the use of drugs targeting endothelial cells (mesoglycan, FFPM, sulodexide). In this study we evaluated the impact of local application of a mixture of semi-synthetic polysulfated galactosaminoglycans on the regression rate of STP and dermo-hypodermitis in patients treated with best medical therapy (BMT). Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05643-4DOI Listing
August 2018
16 Reads

Causes, pathophysiology, and treatment of pruritus in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):140-151. Epub 2017 Oct 17.

Department of Dermatology & Miami Itch Center at the University of Miami, Leonard M. Miller School of Medicine, Miami, FL, USA. Electronic address:

Chronic itch is a common and debilitating health condition in the elderly. There are several common causes of itch in the mature population, such as skin xerosis, immunosenescence, and neuropathic changes. In addition, skin diseases, such as seborrheic dermatitis and stasis dermatitis, systemic conditions (end-stage renal disease and diabetes), or psychogenic derailments, such as depression, anxiety, and dementia, can all serve as triggers of pruritus. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.005DOI Listing
September 2018
74 Reads

Treatment of flat and elevated pigmented disorders with a 755-nm alexandrite picosecond laser: clinical and histological evaluation.

Lasers Med Sci 2018 Nov 9;33(8):1827-1831. Epub 2018 Feb 9.

Dermatology Department, Laser Unit, Hospital Universitario Ramón y Cajal, Ctra Colmenar Viejo Km 9,100, 28034, Madrid, Spain.

The novel picosecond lasers, initially developed for faster tattoo removal, have also shown great efficacy in endogenous pigmentary disorders. To describe the efficacy and safety profile of an alexandrite (755-nm) picosecond laser in a wide range of pigmented flat and elevated cutaneous lesions. A retrospective study was performed in which we collected all the clinical images of patients treated with the 755-nm alexandrite picosecond laser for 12 months (November 2016-November 2017). Read More

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http://link.springer.com/10.1007/s10103-018-2459-z
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http://dx.doi.org/10.1007/s10103-018-2459-zDOI Listing
November 2018
37 Reads

Kaposi's sarcoma concealed by stasis dermatitis in a patient with psoriasis.

Acta Dermatovenerol Alp Pannonica Adriat 2017 09;26(3):69-71

Department of Pathology, Eskisehir Osmangazi University, Eskisehir, Turkey.

Kaposi's sarcoma (KS) is a multifocal and angioproliferative neoplasm. KS may be accompanied by psoriasis; however, in most of these cases the main mechanism involves iatrogenic KS associated with the immunosuppressive drugs that are used in psoriasis treatment. In angioproliferative lesions as a result of venous insufficiency and stasis dermatitis, acroangiodermatitis (pseudo-KS) is initially considered. Read More

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http://dx.doi.org/10.15570/actaapa.2017.22DOI Listing
September 2017
19 Reads

Alitretinoin treatment of lichen amyloidosis.

Dermatol Ther 2017 Nov 14;30(6). Epub 2017 Sep 14.

Department of Dermatology, Hanyang University Hospital, Seoul, South Korea.

Lichen amyloidosis (LA) is characterized by the deposition of amyloid that may respond to chronic scratching that may be secondary to atopic dermatitis, stasis dermatitis, or interface dermatitis. Despite the development of several therapeutic strategies, including topical steroids, oral antihistamines, cyclosporine, and retinoids, an effective treatment for LA has not been established. A 49-year-old woman who has been treated irregularly for atopic dermatitis for 7 years presented with localized brownish papules on the left forearm and right elbow. Read More

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http://dx.doi.org/10.1111/dth.12537DOI Listing
November 2017
63 Reads

Classification and possible bacterial infection in outpatients with eczema and dermatitis in China: A cross-sectional and multicenter study.

Medicine (Baltimore) 2017 Sep;96(35):e7955

aDepartment of Dermatology, Beijing Shijitan Hospital, Capital Medical University bDepartment of Dermatology, Beijing Friendship Hospital, Capital Medical University cMarket Research Department, China Telecom Corporation Limited, Beijing Research Institute, Beijing, China.

Little is known about the classification and bacterial infection in outpatients with eczema and dermatitis in China.To investigate the prevalence of eczema and dermatitis in outpatients of dermatology clinics in China, examine classification and proportion of common types of dermatitis and the possible bacterial infection, and analyze the possible related factors.Outpatients with eczema or dermatitis from 39 tertiary hospitals of 15 provinces in mainland China from July 1 to September 30, 2014, were enrolled in this cross-sectional and multicenter study. Read More

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http://Insights.ovid.com/crossref?an=00005792-201709010-0005
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http://dx.doi.org/10.1097/MD.0000000000007955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585520PMC
September 2017
9 Reads

Punctate Radiation Dermatitis of the Foot and Ankle Caused by Distal Embolization of 90Y Microspheres During Liver Directed Therapy.

Clin Nucl Med 2017 Sep;42(9):e422-e423

From the *College of Medicine, University of Texas Medical Branch, Galveston, TX; †Department of Medical Imaging, and ‡Section of Hematology/Oncology, Department of Medicine, University of Arizona, Tucson, AZ.

A 41-year-old man with gastric adenocarcinoma presented with hepatic metastases. The metastases were refractory to systemic chemotherapy, so radioembolization with Y microspheres was performed. Because of stasis or saturation of the tumor with embolic particles, 79% of the microspheres were injected. Read More

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http://dx.doi.org/10.1097/RLU.0000000000001751DOI Listing
September 2017
6 Reads

It's not what it looks like: atypical rash in cryoglobulinaemic vasculitis.

BMJ Case Rep 2017 Mar 27;2017. Epub 2017 Mar 27.

Reading Health System, West Reading, Pennsylvania, USA.

A 48-year-old man with a history of intravenous drug use and chronic, untreated hepatitis C presented to the emergency room with acute bilateral lower extremity swelling, erythema and maculopapular rash. Serum C4 levels were low, but dermatology felt the rash was due to venous stasis dermatitis. The patient was discharged with compression stockings, but returned to the hospital 5 days later with no improvement in his symptoms. Read More

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http://dx.doi.org/10.1136/bcr-2017-219468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372234PMC
March 2017
13 Reads

Common spongiotic dermatoses.

Semin Diagn Pathol 2017 May 10;34(3):226-236. Epub 2017 Feb 10.

Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.

This review article focuses on the spongiotic tissue reaction pattern and some of the common entities that practicing pathologists can frequently encounter in their practice. The spongiotic tissue reaction pattern is the single most common one encountered in the routine analysis of inflammatory dermatoses, and the most non-specific one as well. Spongiotic dermatoses include a very large list of disorders which are best grouped under neutrophilic, eosinophilic, miliarial, follicular and pityriasiform forms of spogiosis. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.02.002DOI Listing
May 2017
11 Reads

Study on Mucin in Normal-Appearing Leg Skin.

Am J Dermatopathol 2017 Mar;39(3):163-170

Consultant Histopathologist, Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.

Dermal deposits of mucin in the legs have been described associated with venous insufficiency. However, some degree of stasis dermatitis is generally common in aged individuals. Therefore, some amount of mucin is expected a priori in the reticular dermis of aged patients, even in the absence of clinical lesions. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000588DOI Listing
March 2017
5 Reads

The current spectrum of contact sensitization in patients with chronic leg ulcers or stasis dermatitis - new data from the Information Network of Departments of Dermatology (IVDK).

Contact Dermatitis 2017 Sep 14;77(3):151-158. Epub 2017 Feb 14.

Department of Dermatology, University Hospital Erlangen, 91054, Erlangen, Germany.

Background: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization.

Objectives: To identify the current spectrum of contact allergens in these patients.

Patients And Methods: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510). Read More

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http://dx.doi.org/10.1111/cod.12763DOI Listing
September 2017
30 Reads

Stasis Dermatitis: Pathophysiology, Evaluation, and Management.

Am J Clin Dermatol 2017 Jun;18(3):383-390

Department of Dermatology, University of Texas McGovern Medical School at Houston, 6655 Travis St, Ste 980, Houston, TX, 77030, USA.

Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Read More

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http://dx.doi.org/10.1007/s40257-016-0250-0DOI Listing
June 2017
66 Reads

Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis.

Crit Rev Ther Drug Carrier Syst 2016 ;33(3):213-263

Department of Pharmacology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia.

Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Read More

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http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.2016015219DOI Listing
February 2017
46 Reads
4.260 Impact Factor

The Death of Balzac (1799-1850) and the Treatment of Heart Failure During the Nineteenth Century.

J Card Fail 2016 Nov 13;22(11):930-933. Epub 2016 Sep 13.

Department of Public Health and Pediatric Sciences, Legal Medicine Section, University of Turin, Turin, Italy; Unité Mixte de Recherche (UMR) 7268, Laboratoire d'Anthropologie bio-culturelle, Droit, Etique & Santé (Adés), Faculté de Médecine de Marseille, Marseille, France.

Overweight, workaholic, and a caffeine abuser, Honoré de Balzac lived a life of excess. He prematurely died at the age of 51 owing to gangrene associated with congestive heart failure. Textual sources allow us to take a glimpse into his last 3 months of life. Read More

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http://dx.doi.org/10.1016/j.cardfail.2016.09.005DOI Listing
November 2016
9 Reads

Mesenchymal stromal cells: properties and role in management of cutaneous diseases.

J Eur Acad Dermatol Venereol 2017 Mar 19;31(3):414-423. Epub 2016 Sep 19.

Department of Dermatology, Virgen de las Nieves University Hospital, Granada, Spain.

This review describes the current understanding and the potential use of mesenchymal stromal cells (MSCs) in cell-based therapies for clinical management of difficult wounds and other dermatoses. MSCs have been shown to possess many advantageous properties that make them a promising therapeutic modality in dermatology still under investigation. In fact, MSCs' ability to promote wound healing through its paracrine function and pro-angiogenic properties have generated increasing interest for treating acute and chronic wounds. Read More

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http://dx.doi.org/10.1111/jdv.13934DOI Listing
March 2017
5 Reads

Isolation and Characterization of an Atypical Metschnikowia sp. Strain from the Skin Scraping of a Dermatitis Patient.

PLoS One 2016 9;11(6):e0156119. Epub 2016 Jun 9.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

A yeast-like organism was isolated from the skin scraping sample of a stasis dermatitis patient in the Mycology Unit Department of Medical Microbiology, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia. The isolate produced no pigment and was not identifiable using chromogenic agar and API 20C AUX. The fungus was identified as Metschnikowia sp. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156119PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900598PMC
July 2017
12 Reads
1 Citation
3.234 Impact Factor

A Case of Patch Stage of Kaposi's Sarcoma and Discussion of the Differential Diagnosis.

Rare Tumors 2016 Mar 31;8(1):6123. Epub 2016 Mar 31.

Department of Pathology and Molecular Medicine, St. Joseph's Healthcare Hamilton, ON, Canada.

A 55 year old HIV positive male had a skin lesion biopsy which showed atypical vascular proliferation within the superficial and deep dermis with mild atypia of lining endothelial cells. A sparse lymphoplasmacytic infiltrate surrounding the irregular vascular channels was noted. Immunohistochemistry highlighted the atypical blood vessels with the vascular markers CD31, CD34 and Factor VIII. Read More

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http://dx.doi.org/10.4081/rt.2016.6123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827646PMC
March 2016
21 Reads

Dermatological Complaints of the Elderly Attending a Dermatology Outpatient Clinic in Turkey: A Prospective Study over a One-year Period.

Acta Dermatovenerol Croat 2015 ;23(4):277-81

Assoc. Prof. Muhterem Polat, MD, Gazi University School of Medicine, Department of Dermatology, Ankara, Turkey;

The geriatric population is continuously growing, which leads to more aged patients being admitted to dermatology clinics. The aim of this study is to determine the dermatological complaints of the elderly attending a dermatology outpatient clinic. All of the patients aged 65 years and older admitted to our dermatology outpatient clinic over a 1-year period were included. Read More

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February 2017
31 Reads

Ruocco's immunocompromised cutaneous district.

Int J Dermatol 2016 Feb 16;55(2):135-41. Epub 2015 Oct 16.

Dermatology and Pathology, Rutgers New Jersey Medical School, Newark, NJ, USA.

The concept of 'locus minoris resistentiae' (lmr) is an old but still effective way of thinking in Medicine. In Dermatology, there are many reports of privileged localization of cutaneous diseases on injured skin, which therefore represents a typical condition of lmr. Lately the innovative concept of immunocompromised cutaneous district (ICD) has been introduced to explain why a previously injured cutaneous site may become in time a privileged location for the outbreak of opportunistic infections, tumors, and immune reactions. Read More

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http://dx.doi.org/10.1111/ijd.13086DOI Listing
February 2016
15 Reads

Bilateral cellulitis.

BMJ Case Rep 2015 Sep 21;2015. Epub 2015 Sep 21.

Department of Pathology, Johns Hopkins, Baltimore, Maryland, USA.

We present a case of bilateral lesions in a 50-year-old man, which were on first impression mistaken for and initially treated as bilateral cellulitis. We propose that bilateral cellulitis, as opposed to unilateral, is rare and that other aetiologies should be considered in evaluating a patient with bilateral lesions. The differential diagnosis includes stasis-dermatitis, lipodermatosclerosis, lymphoedema and vascular lesions such as Kaposi sarcoma, as was identified in this case. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2015-21111
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http://dx.doi.org/10.1136/bcr-2015-211117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577663PMC
September 2015
15 Reads

Physiological and lifestyle factors contributing to risk and severity of peri-orbital dark circles in the Brazilian population.

An Bras Dermatol 2015 Jul-Aug;90(4):494-503

Medcin Instituto da Pele, Osasco, SP, BR.

Background: Peri-orbital dark circles are a cosmetic concern worldwide, and have been attributed to hyperpigmentation from allergy or atopic dermatitis, blood stasis, structural shadowing effects, and a thin epidermis/dermis under the eye. It is of interest to better understand lifestyle and demographic risk factors and the relative impact of melanin, blood and epidermal/dermal factors on the severity of Peri-orbital dark circles.

Objective: To compare by non-invasive imaging the impact of biological factors to a visual grading scale for Peri-orbital dark circles, and test the correlation of various demographic factors with Peri-orbital dark circles. Read More

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http://www.scielo.br/pdf/abd/v90n4/0365-0596-abd-90-04-0494.
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20153520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560538PMC
March 2016
20 Reads

[Contact allergies in the elderly].

Authors:
V Mahler

Hautarzt 2015 Sep;66(9):665-73

Hautklinik Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland.

The percentage of seniors (> 65 years of age) in the general population continues to rise. Their sensitization profile may be influenced by lifelong work-related and nonwork-related exposures and comorbidities requiring local or systemic treatment. Recent analysis of the IVDK (Information Network of Departments of Dermatology) cohort concerning the most frequently recognized contact allergens in the age group above 65 (2009-2013: N = 14,841) revealed significant differences compared to the age group up to 65 years of age. Read More

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http://link.springer.com/10.1007/s00105-015-3668-z
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http://dx.doi.org/10.1007/s00105-015-3668-zDOI Listing
September 2015
25 Reads

Lipodermatosclerosis: a clinicopathologic correlation.

Int J Dermatol 2016 Mar 14;55(3):303-8. Epub 2015 Aug 14.

Division of Dermatology, Department of Medicine, Srinagarind Hospital Medical School, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Lipodermatosclerosis (LDS) is a chronic fibrosing panniculitis associated with venous insufficiency. Although LDS is often a clinical diagnosis, it can be confused with other panniculitides. Microscopic examination is therefore essential to support the diagnosis in this condition. Read More

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http://dx.doi.org/10.1111/ijd.12856DOI Listing
March 2016
10 Reads

Clinical and microbiological characteristics of purulent and non-purulent cellulitis in hospitalized Taiwanese adults in the era of community-associated methicillin-resistant Staphylococcus aureus.

BMC Infect Dis 2015 Aug 5;15:311. Epub 2015 Aug 5.

Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Background: The risk factors, microbial etiology, differentiation, and clinical features of purulent and non-purulent cellulitis are not well defined in Taiwan.

Methods: We conducted a retrospective cohort study of hospitalized adults with cellulitis in Taiwan in 2013. The demographic characteristics, underlying diseases, clinical manifestations, laboratory and microbiological findings, treatments, and outcomes were compared for patients with purulent and non-purulent cellulitis. Read More

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http://dx.doi.org/10.1186/s12879-015-1064-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526200PMC
August 2015
16 Reads

Stasis papillomatosis with cardiac complications and vein insufficiency.

Acta Dermatovenerol Croat 2015 ;23(2):138-43

Aldona Pietrzak MD, PhD, Chair and Department of Dermatology, Venereology and Pediatric Dermatology , Medical University of Lublin . Lublin. Poland;

We report the case of a 73-year-old man with massive swelling of the lower extremities, with a chronic and rather uncommon form of stasis dermatitis - stasis papillomatosis. The patient was also diagnosed with severe heart failure, including dilated cardiomyopathy, hypothyroidism that required a substantial dose of exogenous tyrosine, microcytic and megaloblastic anemia, iron deficiency, and type 2 diabetes. The cause of stasis dermatitis lesions is not completely understood. Read More

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January 2017
17 Reads

Non-HIV-related Kaposi sarcoma in 2 Hispanic patients arising in the setting of chronic venous insufficiency.

Cutis 2015 Jun;95(6):E30-3

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 530 1st Ave, Ste 7J, New York, NY 10016, USA.

Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus 8 (HHV-8) infection that can be confused with the clinical and histological findings of chronic venous insufficiency. Definitive diagnosis of KS can only be achieved by performing a polymerase chain reaction for HHV-8 or by immunostaining for the HHV-8 antigen. We describe 2 unusual clinical presentations of KS in the setting of chronic venous insufficiency with clinical and histologic features consistent with stasis dermatitis but positive HHV-8 immunostaining. Read More

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June 2015
10 Reads

Inpatient dermatology consultation aids diagnosis of cellulitis among hospitalized patients: A multi-institutional analysis.

J Am Acad Dermatol 2015 Jul;73(1):70-5

Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Given its nonspecific physical examination findings, accurately distinguishing cellulitis from a cellulitis mimicker (pseudocellulitis) is challenging.

Objective: We sought to investigate the national incidence of cellulitis misdiagnosis among inpatients.

Methods: We conducted a retrospective review of inpatient dermatology consultations at Massachusetts General Hospital, University of Alabama at Birmingham Medical Center, University of California Los Angeles Medical Center, and University of California San Francisco Medical Center in 2008. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622140216
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http://dx.doi.org/10.1016/j.jaad.2014.11.012DOI Listing
July 2015
35 Reads

Venous status ulcers due to congenital agenesis of the inferior vena cava in a 16-year-old male.

Vascular 2016 Feb 13;24(1):106-8. Epub 2015 May 13.

Division of Vascular and Endovascular Surgery, Department of Cardiovascular and Thoracic Surgery, Montefiore Medical Center, Bronx, New York, USA.

We report a case of agenesis of the infrarenal inferior vena cava in a 16-year-old male presenting with venous stasis dermatitis and ulceration in the gaiter region bilaterally. Duplex imaging was performed revealing absence of infrarenal inferior vena cava and iliofemoral venous system. Magnetic resonance venography then confirmed the above findings along with revealing extensive lumbar and pelvic collateralization. Read More

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http://dx.doi.org/10.1177/1708538115587453DOI Listing
February 2016
4 Reads

Keratinocyte Migration and a Hypothetical New Role for Extracellular Heat Shock Protein 90 Alpha in Orchestrating Skin Wound Healing.

Adv Wound Care (New Rochelle) 2015 Apr;4(4):203-212

Department of Dermatology, USC Laboratories for Investigative Dermatology, USC/Norris Cancer Center, The Keck Medical Center and the Los Angeles Greater VA Healthcare System, University of Southern California , Los Angeles, California.

The treatment and care of patients with skin wounds are a major healthcare expenditure. Burn wounds, iatrogenic surgical wounds, venous stasis dermatitis ulcers, diabetic lower limb ulcers, pressure ulcers, and skin wounds from peripheral neuropathies are largely treated with only supportive care. Despite a great deal of research into using growth factors as therapeutic agents, to date, the field has been disappointing. Read More

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http://dx.doi.org/10.1089/wound.2014.0566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397998PMC
April 2015
18 Reads

New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report.

Iran Red Crescent Med J 2014 Dec 15;16(12):e19500. Epub 2014 Dec 15.

Department of Radiology, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.

Introduction: In daily practice, it is common to experience difficulty in treating decubitus ulcers (pressure ulcers, also known as decubitus ulcers) and stasis dermatitis of the lower limbs. We hereby report that omega-3-acid ethyl esters were remarkably effective when administered to cases of refractory pressure ulcers and stasis dermatitis for the purpose of improving the blood flow and promoting blood circulation.

Case Presentation: Case 1: A 21-year-old Japanese female with lower-body paralysis. Read More

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http://ircmj.com/36551.pdf
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http://www.ircmj.com/?page=article&article_id=19500
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http://dx.doi.org/10.5812/ircmj.19500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341250PMC
December 2014
7 Reads