172,595 results match your criteria Staphylococcal Scalded Skin Syndrome
ACS Infect Dis 2018 Dec 12. Epub 2018 Dec 12.
The antimicrobial peptide bactofencin A is an unmodified non-pediocin-like bacteriocin that inhibits several clinically relevant pathogens including Listeria monocytogenes and Staphylococcus aureus. Here we report the synthesis and structure-activity relationship studies of bactofencin A and novel analogs thereof. Synthetic bactofencin A was a potent inhibitor of L. Read More
PLoS One 2018 12;13(12):e0207161. Epub 2018 Dec 12.
School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.
The success of Staphylococcus aureus as a pathogen is due in part to its ability to adapt to changing environmental conditions using signal transduction pathways, such as metabolite- responsive regulators and two-component systems. S. aureus has a two-component system encoded by the gene pair sav0224 (hptS) and sav0223 (hptR) that regulate the hexose phosphate transport (uhpT) system in response to extracellular glucose-6-phosphate. Read More
J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.
Department of Biotechnology, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.
Background And Objectives: Breast milk contains several bioactive factors including human milk oligosaccharides (HMOs) and microbes that shape the infant gut microbiota. HMO profile is determined by secretor status; however, their influence on milk microbiota is still uncovered. This study is aimed to determine the impact of the FUT2 genotype on the milk microbiota during the first month of lactation and the association with HMO. Read More
ACS Synth Biol 2018 Dec 12. Epub 2018 Dec 12.
The availability of complete genome sequences and the definition of essential gene sets were fundamental in the start of the genome engineering era. In a recent study, redundant and unnecessary genes were systematically deleted from the Gram-positive bacterium Bacillus subtilis, an industrial production host of high-value secreted proteins. This culminated in strain PG10, which lacks about 36% of the genome, thus representing the most minimal Bacillus chassis currently available. Read More
JAMA Surg 2018 Dec 12. Epub 2018 Dec 12.
Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.
Importance: Limited data suggest that screening for asymptomatic bacteriuria (ASB) prior to nonurologic procedures is not useful. However, high-quality evidence to support consensus recommendations and influence clinical practice is lacking.
Objective: To characterize the association between detection and treatment of preoperative ASB and postoperative outcomes. Read More
J Water Health 2018 Dec;16(6):1029-1032
Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, UK E-mail: School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK and Centre for Experimental Medicine, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
The frequency of seasonal snowfall results in the transient covering of gardens/amenity sites/open public spaces, which encourages recreational interaction mainly with children. No data is available demonstrating the microbiological composition of such fallen snow and therefore a study was undertaken to examine the microbiology of snow from 37 sites, estimating (i) total viable count (TVC), (ii) identification of bacteria, and (iii) the presence of Pseudomonas aeruginosa. Mean TVC count of 8. Read More
J Med Microbiol 2018 Dec 12. Epub 2018 Dec 12.
4Department of Medicine, Campus Biomedico University, Via Alvaro del Portillo 200, 00128 Rome, Italy.
Purpose: Staphylococcus aureus isolates, collected from various clinical samples, were analysed to evaluate the contribution of the genetic background of both erythromycin-resistant (ERSA) and -susceptible (ESSA) S. aureus strains to biofilm formation.
Methods: A total of 66 ESSA and 43 ERSA clinical isolates were studied for adhesiveness and biofilm formation under different atmospheres. Read More
Drugs Today (Barc) 2018 Nov;54(11):657-666
Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Delafloxacin meglumine (Baxdela, WQ-3034, ABT-492, RX-3341; Melinta Therapeutics) was approved by the U.S. Food and Drug Administration (FDA) in June 2017 for the treatment of acute bacterial skin and skin structure infections on the basis of data from two phase III trials. Read More
Open Forum Infect Dis 2018 Nov 20;5(11):ofy265. Epub 2018 Oct 20.
Division of Infectious Diseases, Atlanta, Georgia.
Background: The use of valve surgery for infective endocarditis (IE) in end-stage renal disease (ESRD) patients may be different than in the general population. We assessed predictors of early surgery in ESRD patients with IE.
Methods: We conducted a retrospective cohort study among dialysis patients with left-sided IE between 2005 and 2015. Read More
Biomed Res Int 2018 13;2018:3069595. Epub 2018 Nov 13.
Laboratory of Blue Biotechnology and Aquatic Bioproduction (B3 Aqua), National Institute of Marine Sciences and Technologies (INSTM), 28, 2 march street 1934 -2035 Salammbô, Tunisia.
This study deals with the antimicrobial potential assessment of in regard to collection period and sampling site. Besides, we assess the chemical composition of bioactive compounds. For this purpose, was seasonally collected from two northern sites in Tunisia, Cap Zebib rocky shore (CZ) and Ghar El Melh lagoon (GEM). Read More
Front Pediatr 2018 27;6:359. Epub 2018 Nov 27.
Center for Pediatrics, Department of Neonatology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Human milk (HM) for preterm infants will often be pasteurized for cytomegalovirus (CMV) inactivation and reduction of its bacterial count. High-temperature short-time (HTST) treatment compared to standard Holder pasteurization (HoP) reduces the impact of heat treatment on bioactive HM proteins while effectively inactivating CMV. No data are available for the efficacy of bacterial count reduction using HTST treatments that are available for clinical use. Read More
Evid Based Complement Alternat Med 2018 12;2018:9759240. Epub 2018 Nov 12.
Department of Chemistry and Pharmacy, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, MeditBio, 8005-139 Faro, Portugal.
This study was performed to evaluate the total phenols, flavonoids, and antioxidant activities of twenty-four propolis samples from different regions of Morocco. In addition, two samples were screened regarding the antibacterial effect against four strains. Gas chromatography coupled to mass spectra (GC-MS) analysis was done for propolis samples used in antibacterial tests. Read More
Evid Based Complement Alternat Med 2018 13;2018:4918090. Epub 2018 Nov 13.
Laboratorio de Farmacognosia, UBIPRO Facultad de Estudios Superiores-Iztacala UNAM, Tlalnepantla, Edo. Mex., Mexico.
In the Valley of Tehuacan-Cuicatlan, and are located and are used in traditional medicine. In this research, several biological properties were evaluated. The methanol extracts of (MeCp) and (MeBm) were obtained by maceration. Read More
Curr Zool 2018 Dec 16;64(6):721-726. Epub 2017 Nov 16.
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Contact with environmental microbes are arguably the most common species interaction in which any animal participates. Studies have noted diverse relationships between hosts and resident microbes, which can have strong consequences for host development, physiology, and behavior. Many of these studies focus specifically on pathogens or beneficial microbes, while the benign microbes, of which the majority of bacteria could be described, are often ignored. Read More
Front Microbiol 2018 27;9:2927. Epub 2018 Nov 27.
Laboratory of Food Microbiology, Institute of Food, Nutrition and Health, ETH Zürich, Zürich, Switzerland.
The increasing number of multidrug-resistant bacteria intensifies the need to develop new antimicrobial agents. Endolysins are bacteriophage-derived enzymes that degrade the bacterial cell wall and hold promise as a new class of highly specific and versatile antimicrobials. One major limitation to the therapeutic use of endolysins is their often short serum circulation half-life, mostly due to kidney excretion and lysosomal degradation. Read More
Front Microbiol 2018 27;9:2925. Epub 2018 Nov 27.
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
We investigated -positive and -negative MRSA strains isolated from animals and humans in different geographical areas of China, from 2011 to 2016. Twenty -positive strains (15.6%) were identified from 128 MRSA strains including 17 from food animals and three from humans. Read More
Front Microbiol 2018 27;9:2865. Epub 2018 Nov 27.
EA 4691 Biomaterials and Inflammation in Bone Site (BIOS), SFR Cap Santé (FED 4231), University of Reims-Champagne-Ardenne, Reims, France.
Prosthesis and joint infections are an important threat in public health, especially due to the development of bacterial biofilms and their high resistance to antimicrobials. Biofilm-associated infections increase mortality and morbidity rates as well as hospitalization costs. Prevention is the best strategy for this serious issue, so there is an urgent need to understand the signals that could induce irreversible bacterial adhesion on a prosthesis. Read More
Front Microbiol 2018 27;9:2749. Epub 2018 Nov 27.
Amity Institute of Microbial Technology, Amity University, Noida, India.
S, a notorious human pathogen, is a major cause of the community as well as healthcare associated infections. It can cause a diversity of recalcitrant infections mainly due to the acquisition of resistance to multiple drugs, its diverse range of virulence factors, and the ability to produce biofilm in indwelling medical devices. Such biofilm associated chronic infections often lead to increase in morbidity and mortality posing a high socio-economic burden, especially in developing countries. Read More
Infect Drug Resist 2018 20;11:2363-2375. Epub 2018 Nov 20.
Laboratory of Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China,
Background: Methicillin-resistant (MRSA) causes a wide variety of serious infections worldwide. There are few studies on the prevalence, antimicrobial susceptibility, and molecular characteristics of MRSA contamination in the environment of airports.
Materials And Methods: A cross-sectional survey was conducted in Guangzhou Baiyun Airport. Read More
Infect Drug Resist 2018 21;11:2335-2344. Epub 2018 Nov 21.
Department of Medical Sciences, Clinical Microbiology, Uppsala University, Uppsala, Sweden,
Purpose: To further analyze a clinical isolate originally identified as methicillin-resistant (MRSA) using whole-genome sequencing and comparative genomics.
Materials And Methods: Classical diagnostic methods such as cultivation, biochemical tests, and PCR were supplemented with whole-genome sequencing and comparative genomics, to identify the isolate.
Results: The isolate was phenotypically similar to MRSA. Read More
Int J Nanomedicine 2018 21;13:7789-7799. Epub 2018 Nov 21.
Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Dasauli, Lucknow, India,
Background: Biological synthesis of nanomaterials possesses unprecedented potential in the production of nanomaterials due to their ability to produce nanomaterials with improved biocompatibility in addition to eco-friendly synthetic procedures.
Methods: This article reports the isolation of an air-borne fungus from the campus of Integral University, Lucknow, with an exceptional ability to withstand very high concentrations of silver salt. The fungus was found to produce pentagonal silver nanoparticles (AgPgNps) when silver ions were reduced from silver nitrate. Read More
MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.
Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
The epidemiology of methicillin-resistant has changed considerably over the last 3 decades, including the recognition of lineages associated with the community and with livestock exposure, in addition to nosocomial strains. A recent study by R. N. Read More
MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.
School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia
The World Health Organization reports that antibiotic-resistant pathogens represent an imminent global health disaster for the 21st century. Gram-positive superbugs threaten to breach last-line antibiotic treatment, and the pharmaceutical industry antibiotic development pipeline is waning. Here we report the synergy between ionophore-induced physiological stress in Gram-positive bacteria and antibiotic treatment. Read More
J Biol Chem 2018 Dec 11. Epub 2018 Dec 11.
Chemistry, Pennsylvania State University, United States.
The lipoyl cofactor plays an integral role in several essential biological processes. The last step in its biosynthetic pathway, the attachment of two sulfur atoms at C6 and C8 of an -octanoyl-lysyl chain, is catalyzed by lipoyl synthase (LipA), a member of the radical SAM superfamily. In addition to the [4Fe-4S] cluster common to all radical SAM enzymes, LipA contains a second [4Fe-4S] auxiliary cluster, which is sacrificed during catalysis to supply the requisite sulfur atoms, rendering the protein inactive for further turnovers. Read More
Biol Res Nurs 2018 Dec 11:1099800418818387. Epub 2018 Dec 11.
2 Faculty of Nursing, Catholic University of Murcia (UCAM), Murcia, Spain.
Introduction And Objectives:: Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen causing nosocomial infections in hospitals and health centers. This work is an effort to understand the epidemiology of MRSA and other multidrug-resistant pathogens in an intensive care unit (ICU) and to analyze characteristics that might determine the risk of MRSA colonization/infection in this unit.
Method:: An observational, 1-year prospective longitudinal study was conducted to obtain information about MRSA and other multidrug-resistant colonizations/infections. Read More
J Cardiol Cases 2013 Jan 5;7(1):e15-e17. Epub 2012 Oct 5.
Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey.
Infective endocarditis (IE) remains a serious and deadly disease despite recent advances in diagnosis and treatment. In all IE cases, the rate of healthcare-associated IE has been reported as 23%. Aortic valve endocarditis may extend to mitral-aortic intervalvular fibrosa (MAIVF), which may cause pseudoaneurysm formation and subsequent perforation. Read More
Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.
Canadian Wildlife Health Cooperative, Abbotsford, British Columbia, Canada.
Urban Norway rat (Rattus norvegicus) populations can carry the bacteria methicillin-resistant Staphylococcus aureus (MRSA). There are numerous knowledge gaps in the epidemiology of MRSA in these populations that limit understanding of its ecology in urban environments. For example, fecal shedding of MRSA, which may increase environmental contamination, has been reported in other species; however, it is unknown whether Norway rats carry the bacteria rectally. Read More
Plant Biotechnol J 2018 Dec 10. Epub 2018 Dec 10.
Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
The CRISPR- Streptococcus pyogenes Cas9 (SpCas9) system offers a rapid, simple and flexible genome editing approach. However, the targeting scope of the SpCas9 system is limited by the canonical NGG PAM. To broaden the editing range of the CRISPR system, several Cas orthologs recognized different PAM were isolated from diverse microbes and were engineered as powerful genome editing tools in eukaryotic cells (Murovec et al. Read More
J Food Sci 2018 Dec;83(12):2970-2975
Dept. of Biological Sciences and Health, Federal Univ. of Amapa, Rod. Juscelino Kubitschek, Km-02 - Jardim Marco Zero, Macapá-AP, 68903-419, Brazil.
Ellagic acid (EA) has demonstrated several biological properties, such as antioxidant, antimicrobial, and enzymatic inhibition. Zein and chitosan (CHI) are natural polymers whose biological potential has also gained attention. Therefore, this paper aimed to evaluate the antimicrobial, antioxidant, anticollagenase, and antielastase properties of EA, zein, and chitosan isolated or in combination. Read More
Probiotics Antimicrob Proteins 2018 Dec 7. Epub 2018 Dec 7.
Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Galeazzi 4, 20164, Milan, Italy.
Changes in bacterial composition of nasal microbiota may alter the host's susceptibility to several infectious and allergic diseases such as chronic rhinosinusitis and allergic rhinitis. The aim of this study was to evaluate the effects of 1-week administration of a probiotic product, composed by a combination of Streptococcus salivarius 24SMBc and Streptococcus oralis 89a, on the nostril microbiota. Differences in the nasal microbiota composition were investigated by using a next-generation sequencing approach. Read More
Clin Infect Dis 2018 Dec 9. Epub 2018 Dec 9.
Pediatric Emergency Medicine, Chief of Critical Care Services, Children's Minnesota, Minneapolis, MN, USA.
Background: Bloodstream infections (BSIs) cause significant morbidity and mortality in children. Recent pediatric epidemiological data may inform prevention strategies and empiric antimicrobial therapy selection.
Methods: We conducted a retrospective cohort study from 2009-2016 utilizing demographic and microbiology data on inpatients <19 years using the Premier Healthcare Database. Read More
Rev Chilena Infectol 2018 ;35(3):225-232
Escuela Superior de Medicina, Instituto Politécnico Nacional, Instituto Mexicano del Seguro Social, México, D.F, México.
Background: Peritonitis is the most important and frequent complication of peritoneal dialysis (PD). Bacterial infections are responsible in most cases, with characteristic symptoms.
Aim: To determine the most frequent pathogens in peritonitis associated with PD in patients with chronic renal failure (CRF). Read More
Commun Biol 2018 7;1:220. Epub 2018 Dec 7.
Robert Frederick Smith School of Chemical and Biomolecular Engineering, 120 Olin Hall, Cornell University, Ithaca, NY 14853 USA.
Cationic charge and hydrophobicity have long been understood to drive the potency and selectivity of antimicrobial peptides (AMPs). However, these properties alone struggle to guide broad success in vivo, where AMPs must differentiate bacterial and mammalian cells, while avoiding complex barriers. New parameters describing the biophysical processes of membrane disruption could provide new opportunities for antimicrobial optimization. Read More
mSystems 2018 Nov-Dec;3(6). Epub 2018 Dec 4.
The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.
The expanded Human Oral Microbiome Database (eHOMD) is a comprehensive microbiome database for sites along the human aerodigestive tract that revealed new insights into the nostril microbiome. The eHOMD provides well-curated 16S rRNA gene reference sequences linked to available genomes and enables assignment of species-level taxonomy to most next-generation sequences derived from diverse aerodigestive tract sites, including the nasal passages, sinuses, throat, esophagus, and mouth. Using minimum entropy decomposition coupled with the RDP Classifier and our eHOMD V1-V3 training set, we reanalyzed 16S rRNA V1-V3 sequences from the nostrils of 210 Human Microbiome Project participants at the species level, revealing four key insights. Read More
J Vet Med 2018 11;2018:3801479. Epub 2018 Nov 11.
Department of Animal Sciences, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000-00200, Nairobi, Kenya.
A cross-sectional study was carried out to determine the prevalence and risk factors of subclinical mastitis in dairy goats in Thika East Subcounty, Kenya. Further the bacterial pathogens and their antibiogram were investigated. Farm level data on risk factors were obtained from 41 farmers using questionnaires. Read More
New Microbes New Infect 2019 Jan 16;27:29-35. Epub 2018 Nov 16.
Department of Pathobiology, School of Public Health and Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Health-care workers may serve as a reservoir for dissemination of methicillin-resistant (MRSA) to patients in hospital settings. The present study aimed to screen MRSA in nasal swabs of health-care workers and clinical specimens from patients and investigate the possible relationship between these isolates at a university hospital in Tehran, Iran. Additionally, we aimed to identify potential risk factors for MRSA colonization in health-care workers. Read More
Int J Microbiol 2018 11;2018:3912326. Epub 2018 Nov 11.
Department of Microbiology, Kazan Federal University, Kremlevskaya Str. 18, Kazan 420008, Russia.
colonizing gastrointestinal and urogenital tracts of humans and animals is widely used in manufacturing of fermented products and as probiotics. These bacteria may function as vehicles of antibiotic resistance genes, which can be transferred to pathogenic bacteria. Therefore, monitoring and control of transmissible antibiotic resistance determinants in these microorganisms is necessary to approve their safety status. Read More
Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):3-7
Virginia Commonwealth University, School of Pharmacy, Richmond, Virginia.
Objective: Cellulitis is a commonly encountered medical illness and is most frequently caused by Group A β-hemolytic species and . The purpose of this study was to compare clinical outcomes of patients with lower extremity cellulitis treated with broad-spectrum and narrow-spectrum antibiotics.
Methods: This was a retrospective cohort study conducted in a community tertiary hospital between January 2016 and May 2016. Read More
Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.
Centre for Antimicrobial Resistance, Alberta Health Services/Calgary Laboratory Services/University of Calgary, Calgary, Alberta, Canada.
Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 8 (CC8) sequence type 239 (ST239) represents a predominant hospital-associated MRSA sublineage present worldwide. The Canadian epidemic MRSA strains CMRSA3 and CMRSA6 are moderately virulent members of this group but are closely related to the highly virulent strain TW20. Whole-genome sequencing of CMRSA3 and CMRSA6 was conducted to identify genetic determinants associated with their virulence. Read More
Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.
Animal & Bioscience Department, Teagasc, Grange, Dunsany, Co. Meath, Ireland.
This is the announcement of draft genome sequences for Staphylococcus aureus strains belonging to sequence type 97 (ST97) and ST71. These sequence types are commonly associated with bovine mastitis, and the strains were isolated in Ireland in 2010 from the milk of cows with clinical mastitis. Read More
Microbiol Resour Announc 2018 Aug 2;7(4). Epub 2018 Aug 2.
Curtin Health Innovation Research Institute and School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.
Staphylococcus aureus is a serious pathogen of humans and animals. Multilocus sequence type 612 is dominant and highly virulent in South African hospitals but relatively uncommon elsewhere. We present the complete genome sequence of methicillin-resistant Staphylococcus aureus strain SVH7513, isolated from a horse at a veterinary clinic in New South Wales, Australia. Read More
Microbiol Resour Announc 2018 Nov 8;7(18). Epub 2018 Nov 8.
Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Staphylococcus aureus reference strain ATCC 25923 has been maintained for more than a decade in our laboratory. Genomic study revealed that the resulting strain AFIPCBER_B_8.4 has lost a 37-kb genomic fragment of the ATCC 25923 parental strain. Read More
Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.
Department of Genetics and Molecular Biology of Bacteria, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow, Russia.
We present here draft genome sequences of five Staphylococcus aureus strains obtained from children suffering from atopic dermatitis. The strains were determined to be of five different sequence types (sequence type 1 [ST1], ST7, ST8, ST15, and ST101) and carried a unique combination of superantigen-like protein (SSL) and serine protease genes. Read More
Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, Bari, Italy.
The genome sequences of three new strains of Staphylococcus arlettae named Bari1, Bari2, and Bari3 are presented. The strains exhibited tolerance to hexavalent chromium ions. An gene encoding a putative chromium transporter was present in each of the three draft genome sequences. Read More
Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA.
Staphylococcus aureus is the causative agent of multiple infections, including bacteremia, infective endocarditis, osteomyelitis, septic arthritis, and prosthetic device infections. We report here the first whole-genome sequence for four S. aureus sequence type 398 isolates from clinical cases of osteomyelitis in four goats with a history of orthopedic surgery. Read More
JB JS Open Access 2018 Sep 12;3(3):e0060. Epub 2018 Jul 12.
Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
Background: Culture-negative periprosthetic joint infection (PJI) is a challenging condition to treat. The most appropriate management of culture-negative PJI is not known, and there is immense variability in the treatment outcome of this condition. The purpose of this study was to elucidate the characteristics, outcomes, and risk factors for failure of treatment of culture-negative PJI. Read More
ACS Omega 2018 Nov 8;3(11):15125-15133. Epub 2018 Nov 8.
Department of Molecular Microbiology and Immunology, The Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.
Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and α-hydroxytropolones (α-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against , , and . Read More
Bioact Mater 2019 Mar 23;4(1):17-21. Epub 2018 Nov 23.
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.
Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment . Thus, the development of novel implant materials is quite urgent. Read More
J Bone Jt Infect 2018 24;3(5):255-257. Epub 2018 Nov 24.
Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, Nantes, France.
After rifampin and levofloxacin treatment for a bone infection, a pyogenic granuloma due to a newly described species, developed on the tibia former external fixator. This rifampin resistant bacterium, selected during treatment, harbored a mutation in the gene. This case illustrates the possible selection of resistant mutant most likely due to the bacterial burden and therefore the importance of adequate bone infection treatment. Read More
J Bone Jt Infect 2018 31;3(5):241-244. Epub 2018 Oct 31.
Bone-and-Joint Infections Referral Center, Hôpital Croix Saint-Simon, 125, rue d'Avron 75020 Paris, France.
Prosthetic joint infections (PJIs) can be acquired hematogenously from a distant site or device. Notably, 30%-40% of patients with PJIs have bacteremia. No case reports or series of PJIs acquired from totally implantable venous-access device (TIVAD) infection or colonization have been published. Read More