607 results match your criteria Staphylococcal Scalded Skin Syndrome

50 Years Ago in TheJournalofPediatrics: The Baptism of Staphylococcal Scalded Skin Syndrome: Old is Gold.

J Pediatr 2021 Jun;233:81

Department of Pediatrics, University College of Medical Sciences, Delhi, India.

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Demographic characteristics, clinical features, and optimal management of hospitalized patients with staphylococcal scalded skin syndrome.

Pediatr Dermatol 2021 May 18. Epub 2021 May 18.

Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.

Background/objectives: Optimal management of staphylococcal scalded skin syndrome (SSSS) has not been established. Clindamycin may benefit patients via inhibition of ribosomal toxin production, but resistance patterns suggest penicillinase-resistant penicillins or cephalosporins should be the first line. Our goal was to describe demographic and clinical characteristics of SSSS patients at our institution, delineate bacterial resistance patterns, and examine outcomes of varying therapeutic strategies in SSSS. Read More

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Antibiotic Regimens and Associated Outcomes in Children Hospitalized With Staphylococcal Scalded Skin Syndrome.

J Hosp Med 2021 Mar;16(3):149-155

Section of Pediatric Hospital Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: Controversy exists regarding the optimal antibiotic regimen for use in hospitalized children with staphylococcal scalded skin syndrome (SSSS). Various regimens may confer toxin suppression and/or additional coverage for methicillin-susceptible Staphylococcus aureus (MSSA) or methicillin-resistant S aureus (MRSA).

Objectives: To describe antibiotic regimens in hospitalized children with SSSS and examine the association between antistaphylococcal antibiotic regimens and patient outcomes. Read More

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Complete Genome Sequence of Exfoliative Toxin-Producing Staphylococcus aureus Strain MSSA_SSSS_01, Obtained from a Case of Staphylococcal Scalded-Skin Syndrome.

Microbiol Resour Announc 2021 Feb 11;10(6). Epub 2021 Feb 11.

Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA

Here, we announce the complete genome sequence of an exfoliative toxin-producing strain of sequence type 582 (ST582), isolated from a case of staphylococcal scalded-skin syndrome. The genome consists of a single circularized unitig with a total length of 2,792,190 bp carrying 2,699 genes. The genome is the basis for future epidemiological and genomic studies. Read More

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February 2021

Antimicrobial Resistance and Molecular Analysis of in Staphylococcal Scalded Skin Syndrome among Children in Korea.

J Korean Med Sci 2021 Jan 18;36(3):e22. Epub 2021 Jan 18.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Background: Staphylococcal scalded skin syndrome (SSSS) is a skin disease characterized by blistering and desquamation caused by exfoliative toxins (ETs) of (). Although many countries show predominance of methicillin-susceptible (MSSA), cases of methicillin-resistant (MRSA) have been reported.

Methods: Twenty-six children aged <15 years diagnosed with SSSS from January 2010 to December 2017 from three hospitals were included. Read More

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January 2021

Staphylococcal scalded skin syndrome: An epidemiological and clinical review of 84 cases.

Pediatr Dermatol 2021 Jan 1;38(1):149-153. Epub 2020 Dec 1.

Division of Pediatric Medicine, Section of Dermatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Background: Staphylococcal scalded skin syndrome (SSSS) is a toxin-mediated, blistering skin disorder that mainly affects infants and children. There is limited literature regarding pediatric SSSS. The purpose of this study was to describe the epidemiology, clinical features, and management of pediatric SSSS. Read More

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January 2021

Kawasaki disease mimickers.

Pediatr Int 2020 Nov 29. Epub 2020 Nov 29.

Clinical Immunology Department, Instituto Nacional de Pediatría, Mexico City.

Background: Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects patients younger than five years. In the absence of an available affordable diagnostic test, detailed clinical history and physical examination are still fundamental to make a diagnosis.

Methods: We present five representative cases with KD-like presentation; Systemic onset juvenile idiopathic arthritis, Mycoplasma-induced rash and mucositis, Staphylococcal scalded skin syndrome, BCGosis and the recently described Multisystemic inflammatory syndrome in children (MIS-C) associated with SARS-CoV2. Read More

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November 2020

Comparison of adult vs. paediatric inpatients with staphylococcal scalded skin syndrome: a retrospective database analysis.

Br J Dermatol 2021 04 1;184(4):767-769. Epub 2021 Feb 1.

Department of Dermatology, Rutgers New Jersey Medical School, Newark, NJ, USA.

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Perinatal chikungunya induced scalded skin syndrome.

IDCases 2020 25;22:e00969. Epub 2020 Sep 25.

Center for Clinical Studies, Webster, TX, United States.

Chikungunya is a rapidly emerging infectious disease worldwide caused by a virus that belongs to the Togaviridae family. It can have varied presentations, but vesiculobullous lesions are commonly described. A widespread dissemination of such lesions, however, is extremely rare. Read More

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September 2020

Staphylococcal scalded-skin syndrome in preterm infants: A case report.

Australas J Dermatol 2021 Feb 13;62(1):e129-e130. Epub 2020 Jul 13.

Division of Neonatology, Department of Pediatrics, Fondazione Policlinico "A. Gemelli" IRCCS, Catholic University of the Sacred Heart, Rome, Italy.

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February 2021

Vancomycin for severe staphylococcal scalded skin syndrome.

J Paediatr Child Health 2021 May 28;57(5):747-748. Epub 2020 Jun 28.

Department of Paediatrics, Asahi General Hospital, Chiba, Japan.

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Synergistic antimicrobial activity of melittin with clindamycin on the expression of encoding exfoliative toxin in Staphylococcus aureus.

Toxicon 2020 Aug 22;183:11-19. Epub 2020 May 22.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus is an opportunistic human pathogens, with the ability to produce a series of virulence factors that contribute to the severity of infections. Exfoliative toxins (ETs) are one of the important virulence factors that participating in staphylococcal scalded skin syndrome. Melittin has different biological activities, comprising of antiviral, broad spectrum antibacterial, antiprotozoal, antifungal and anti-inflammatory effects. Read More

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The Role of Gram Staining in Staphylococcal Scalded Skin Syndrome.

Cureus 2020 Apr 10;12(4):e7624. Epub 2020 Apr 10.

Medicine, Universidad Anáhuac Mexico, Mexico City, MEX.

Staphylococcal scalded skin syndrome (SSSS) is a severe blistering disease common in children. The diagnosis of SSSS is often difficult to distinguish from other blistering diseases in children. Here, we report a case of SSSS with a particular diagnostic step to elucidate the disease, which is the Gram stain. Read More

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Clindamycin induced toxic epidermal necrolysis versus Staphylococcal scalded skin syndrome: a case report.

Oxf Med Case Reports 2020 Mar 6;2020(3):omaa020. Epub 2020 May 6.

National University of Ireland, Galway, Ireland.

Toxic epidermal necrolysis and Staphylococcal scalded skin syndrome (SSSS) are potentially life-threatening dermatological emergencies that present in a similar clinical fashion. Toxic epidermal necrolysis is typically triggered by anticonvulsant and other neurological medications and reports clindamycin inducing the disease is exceedingly rare. SSSS seldomly occurs in adult patients. Read More

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Pediatric dermatology emergencies.

Cutis 2020 03;105(3):132-136

Division of Dermatology, Loyola University Medical Center, Maywood, Illinois, USA.

Many pediatric skin conditions can be safely monitored with minimal intervention, but certain skin conditions are emergent and require immediate attention and proper assessment of the neonate, infant, or child. We review the following pediatric dermatology emergencies so that clinicians can detect and accurately diagnose these conditions to avoid delayed treatment and considerable morbidity and mortality if missed: staphylococcal scalded skin syndrome (SSSS), impetigo, eczema herpeticum (EH), Langerhans cell histiocytosis (LCH), infantile hemangioma (IH), and IgA vasculitis. Read More

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Impetigo/Staphylococcal Scalded Skin Disease.

Pediatr Rev 2020 Apr;41(4):210-212

Children's National Medical Center, Washington, DC.

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Dermatoscopy in life-threatening and severe acute rashes.

Clin Dermatol 2020 Jan - Feb;38(1):113-121. Epub 2019 Nov 11.

Institute of Dermatology, Santa Maria della Misericordia University Hospital, Udine, Italy.

A prompt recognition of life-threatening and severe acute rashes is of utmost importance to start an appropriate therapy as soon as possible. Consequently, clinicians often must rely only on clinical data to make a diagnosis because some diagnostic procedures may take a relatively long time to be performed (eg, histologic examination, microbiologic tests). In this scenario, dermatoscopy may be useful as an auxiliary tool to support the diagnosis by highlighting subclinical features. Read More

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[Staphylococcal scalded skin syndrome in a pediatric patient with atopic dermatitis].

Arch Argent Pediatr 2020 02;118(1):e30-e33

Servicio de Pediatría, Hospital General Universitario de Ciudad Real, España.

The staphylococcal scalded skin syndrome is a rare dermatological entity that in early stages may be confused with a flare-up of a rush of atopic dermatitis. We present the case of an 8-year-old boy with a history of atopic dermatitis and egg allergy that went to the Emergency Department for erythematous-bullous lesions on the skin. Symptoms began as an erythema in areas of flexures, which associated conjunctivitis and bilateral eyelid erythema. Read More

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February 2020

Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells.

Infect Immun 2020 01 22;88(2). Epub 2020 Jan 22.

Department of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

While investigating the virulence traits of adhering to the skin of atopic-dermatitis (AD) patients, we identified a novel open reading frame (ORF) with structural similarity to a superantigen from genome sequence data of an isolate from AD skin. Concurrently, the same ORF was identified in a bovine isolate of and designated SElY (H. K. Read More

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January 2020

Increasing Numbers of Staphylococcal Scalded Skin Syndrome Cases Caused by ST121 in Houston, Texas.

Pediatr Infect Dis J 2020 01;39(1):30-34

From the Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine.

Background: The molecular epidemiology of Staphylococcus aureus strains causing staphylococcal scalded skin syndrome (SSSS) in the United States has not been described. We analyzed patient and S. aureus isolate characteristics associated with SSSS in children at Texas Children's Hospital. Read More

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January 2020

Presentation and Management of Staphylococcal Scalded Skin Syndrome in a Child After a Burn Injury: A Case Report.

J Burn Care Res 2020 Jan;41(1):220-223

Department of Plastic Surgery and Burns, Birmingham Children's Hospital, UK.

This case report describes the clinical course of a child who developed staphylococcal scalded skin syndrome (SSSS) after a burn injury. The intent is to aid other units in recognizing the presentation of SSSS after a pediatric burn and to optimize subsequent management. The main clinical finding was of rapid, progressive, superficial epidermal loss at sites separate from the original burn, involving 55% of the total body surface area, 13 days after a 6% scald burn to the face, neck, and chest. Read More

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January 2020

Antibiotic sensitivity and clinical outcomes in staphylococcal scalded skin syndrome.

Pediatr Dermatol 2020 Jan 18;37(1):222-223. Epub 2019 Oct 18.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Staphylococcal scalded skin syndrome causes widespread skin denudation primarily in infants < 1 year old. Selection of empiric therapy is complicated by rising rates of antibiotic resistance in community-acquired staphylococcal infections. Consistent with a previous study, this retrospective review found that SSSS-associated isolates were more likely to be clindamycin-resistant and less likely to be methicillin-resistant compared to overall staphylococcal infections. Read More

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January 2020

The spectrum of staphylococcal scalded skin syndrome: a case series in children.

Clin Exp Dermatol 2020 Apr 22;45(3):333-336. Epub 2019 Nov 22.

Department of Dermatology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by certain toxigenic strains of Staphylococcus aureus. While the classic severe phenotype is widely recognized in children, SSSS in fact exists on a spectrum with mild and moderate variants. Misunderstanding the phenotypic spectrum of SSSS may result in misdiagnosis of an otherwise treatable condition. Read More

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Neonatal staphylococcal scalded skin syndrome in a breastfed neonate.

J Eur Acad Dermatol Venereol 2020 Jan 5;34(1):e36-e38. Epub 2019 Sep 5.

Department of Dermatology and Reference Center for Genodermatoses and Rare Skin Diseases (MAGEC), Université de Paris AP-HP-5, Hôpital Universitaire Necker-Enfants Malades, Paris, France.

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January 2020

Desquamative Dermatitis: A Dermatopathologic Emergency with Poorly Understood Etiopathogenesis.

Skinmed 2019;17(2):111-113. Epub 2019 May 29.

Department of Dermatology, Rutgers - New Jersey Medical School, Newark, NJ;

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December 2019

A Desquamating Skin Rash in a Pediatric Patient.

Clin Pract Cases Emerg Med 2019 May 26;3(2):112-114. Epub 2019 Feb 26.

Naval Medical Center San Diego, Department of Emergency Medicine, San Diego, California.

Prompt identification and treatment of true dermatologic emergencies is essential in emergency medicine, especially in vulnerable populations such as pediatric patients. This is a case of a three-year-old female who presented with significant dehydration in the setting of a desquamating skin rash diagnosed in our emergency department as staphylococcal scalded skin syndrome. Read More

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Newborn with desquamating rash.

J Fam Pract 2019 Apr;68(3):175-177

Paniolo Family Medicine, Kamuela, Hawaii, USA.

A 9-day-old boy was brought to the emergency department by his mother. The infant had been doing well until his most recent diaper change when his mother noticed a rash around the umbilicus, genitalia, and anus. The infant was born at term via spontaneous vaginal delivery. Read More

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Staphylococcal Scalded Skin Syndrome: A Pediatric Dermatological Emergency.

Adv Emerg Nurs J 2019 Apr/Jun;41(2):129-134

The University of North Carolina at Charlotte; and Mid-Atlantic Emergency Medicine Associates, Charlotte, North Carolina.

Staphylococcal scalded skin syndrome (SSSS) is a major exfoliating skin infection primarily seen in neonates and young children that can lead to serious morbidity. Although this condition is not commonly encountered, evidence indicates that the incidence and prevalence of this infection is increasing. It is essential that emergency care providers are knowledgeable regarding the differential diagnosis and clinical-decision making process for accurate and timely diagnosis and treatment. Read More

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Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019

A young girl with a painful rash.

J Fam Pract 2019 Jan/Feb;68(1):E25-E27

Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA. Email:

The speed with which this rash spread and the fact that the patient's skin sloughed off when pressure was applied made the diagnosis clear. Read More

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October 2019