622 results match your criteria Staphylococcal Scalded Skin Syndrome

The Molting Man: Anasarca-Induced Full-Body Desquamation.

Cutis 2022 Apr;109(4):221-223

Dr. Kou is from Des Moines University College of Osteopathic Medicine, Iowa. Dr. Kolb is from Olmsted Medical Center, Rochester, Minnesota. Dr. Kelada is from Roseville Family Healthcare, California. Dr. Schmieder is from the Department of Dermatology, Orange Park Medical Center, Florida.

Blisters and subsequent desquamation of the skin in the presence of acute edema is a well-known clinical phenomenon. In this case report, we describe a new variant that we have termed anasarca-induced desquamation in a 50-year-old man with molting of the entire cutaneous surface after acute edema, in a setting of 40-lb weight gain over 5 days. Laboratory workup for infectious causes and punch biopsies of skin lesions ruled out Stevens-Johnson syndrome and staphylococcal scalded skin syndrome, which have a similar clinical presentation to anasarca-induced desquamation. Read More

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Predominance of community-associated, methicillin-susceptible infections among hospitalized children and adolescents.

J Med Microbiol 2022 Mar;71(3)

Department of Paediatrics, School of Medicine, University of Crete, Heraklion, Greece.

infections cause significant morbidity and mortality in children and adolescents. There is limited data on the characteristics of infections requiring hospitalization in childhood.To investigate the molecular epidemiology and antibiotic resistance of clinical isolates from children and adolescents. Read More

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Three-Dimensional Structure Characterization and Inhibition Study of Exfoliative Toxin D From .

Front Pharmacol 2022 18;13:800970. Epub 2022 Feb 18.

Department of Biosciences COMSATS University Islamabad, Islamabad, Pakistan.

The exfoliative toxins (ETs) are the main toxins that produce staphylococcal scalded skin syndrome (SSSS), an abscess skin disorder. The victims of the disease are usually newborns and kids, as well as grown-up people. Five ETs namely, exfoliative toxins A, B, C, D, and E have been identified in . Read More

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February 2022

Feeling the burn: Sunburn recall in staphylococcal scalded skin syndrome.

Pediatr Dermatol 2022 Mar 17;39(2):330-332. Epub 2022 Feb 17.

George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

Staphylococcal scalded skin syndrome (SSSS) occurs primarily in infants and young children due to hematogenous dissemination of Staphylococcus aureus (S. aureus) exfoliative toxin resulting in painful erythema and superficial desquamation of the skin. Herein, we discuss a 7-year-old patient with SSSS in classic locations who additionally presented with photodistributed erythema without desquamation on the chest, arms, and back in locations of a recently healed sunburn. Read More

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Rapidly Progressive Erythroderma.

Am Fam Physician 2022 01;105(1):75-76

Largo Medical Center, Largo, FL, USA.

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January 2022

A Case Report of an Infant with Autosomal Recessive Dystrophic Epidermolysis Bullosa: COL7A1 Gene Mutations at C2005T and G7922A.

Jing Liu Lin Wang

Acta Dermatovenerol Croat 2021 Dec;29(3):164-166

Jing Liu, MD, Huaibei People's Hospital (The Huaibei Clinical College of Xuzhou Medical University), Huaibei City, China;

A male infant was born by spontaneous delivery on February 7, 2020, with a gestational age of 40 weeks and a birth weight of 4.1 kg. After birth, the infant presented with appearance of skin loss on the bilateral lower limbs, feet, left wrist, face, and lips. Read More

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December 2021

MSI-1 combats drug-resistant S. aureus by affecting bacterial viability and inhibiting carotenoid pigment production.

Microbiol Res 2021 Oct 27;255:126909. Epub 2021 Oct 27.

School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing, Jiangsu, 211198, China. Electronic address:

Development of novel therapeutic strategies and antibacterial agents against antibiotic-resistant Staphylococcus aureus (S. aureus) is urgent. In this study, antibacterial activities and possible mechanisms of peptide MSI-1 against multiple drug-resistant S. Read More

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October 2021

Staphylococcal Scalded Skin Syndrome and Bullous Impetigo.

Medicina (Kaunas) 2021 Oct 24;57(11). Epub 2021 Oct 24.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL 32610, USA.

Staphylococcal scalded skin syndrome (SSSS) and bullous impetigo are infections caused by . The pathogenesis of both conditions centers around exotoxin mediated cleavage of desmoglein-1, which results in intraepidermal desquamation. Bullous impetigo is due to the local release of these toxins and thus, often presents with localized skin findings, whereas SSSS is from the systemic spread of these toxins, resulting in a more generalized rash and severe presentation. Read More

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October 2021

Recognizing and Managing Staphylococcal Scalded Skin Syndrome in the Emergency Department.

Pediatr Emerg Care 2022 Mar;38(3):133-135

UTMB School of Medicine, Galveston, TX.

Abstract: Staphylococcal scalded skin syndrome is a superficial blistering disorder caused by exfoliative toxin-releasing strains of Staphylococcus aureus. Bacterial toxins are released hematogenously, and after a prodromal fever and exquisite tenderness of skin, patients present with tender erythroderma and flaccid bullae with subsequent superficial generalized exfoliation. The head-to-toe directed exfoliation lasts up to 10 to 14 days without scarring after proper treatment. Read More

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Management of Infectious Emergencies for the Inpatient Dermatologist.

Curr Dermatol Rep 2021 6;10(4):232-242. Epub 2021 Oct 6.

Department of Dermatology, Duke University, Durham, NC 27710 USA.

Purpose Of Review: There are various dermatologic emergencies stemming from bacterial, viral, and fungal etiologies that can present in the inpatient setting. This review summarizes the pathogenesis and diagnosis of infections with cutaneous involvement and highlights new therapies.

Recent Findings: Clindamycin inhibits toxin formation and can be used as an adjunct therapy for the staphylococcal scalded syndrome. Read More

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October 2021

[Staphylococcal scalded skin syndrom: a case report].

Pan Afr Med J 2021 6;39:177. Epub 2021 Jul 6.

Service de Gastro-Entérologie, Université Mohammed VI des Sciences de la Santé (UM6SS), Hôpital Cheikh Khalifa Bin Zayd Al Nahyan, Casablanca, Royaume du Maroc.

Staphylococcal scalded skin syndrom is a bullous dermatosis induced by exfoliating staphylococcal exotoxins. Children are most often affected. We report the case of a 6-month-old infant who had angina in the few days before leading up to bullous erythroderma and whose skin biopsy showed characteristic appearance of staphylococcal scalded skin syndrom. Read More

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October 2021

Peeling Skin Syndrome: An Easily Missed Rare Entity.

Skinmed 2021 1;19(4):305-307. Epub 2021 Aug 1.

Department of Dermatology and Venereology, All India Institute of Medical Science, Bhubaneswar, Odisha, India.

A 6-year-old boy with Down's syndrome presented with recurrent episodes of asymptomatic peeling of the skin from the trunk, palms, soles, and face since he was 2 years old. He was the first child of a non-consanguineous marriage. There was no history of any seasonal aggravation or variation. Read More

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January 2022

Genomic Epidemiology and Global Population Structure of Exfoliative Toxin A-Producing Strains Associated With Staphylococcal Scalded Skin Syndrome.

Front Microbiol 2021 18;12:663831. Epub 2021 Aug 18.

Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, United States.

Staphylococci producing exfoliative toxins are the causative agents of staphylococcal scalded skin syndrome (SSSS). Exfoliative toxin A (ETA) is encoded by , which is harbored on a temperate bacteriophage ΦETA. A recent increase in the incidence of SSSS in North America has been observed; yet it is largely unknown whether this is the result of host range expansion of ΦETA or migration and emergence of established lineages. Read More

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Antibiotic-resistant profile and the factors affecting the intravenous antibiotic treatment course of generalized Staphylococcal Scalded Skin Syndrome: a retrospective study.

Ital J Pediatr 2021 Aug 6;47(1):169. Epub 2021 Aug 6.

Department of Dermatology and Venereology, Candidate Branch of National Clinical Research Centre for Skin and Immune Diseases, The First Affiliated Hospital of Gannan Medical University, No. 23 Qingnian Road, Zhanggong District, Ganzhou, 341000, China.

Background: Staphylococcal Scalded Skin Syndrome (SSSS) is caused by a special type of Staphylococcus aureus (S.aureus) which can produce exfoliative toxins. The generalized SSSS is recommended to be admitted and treated with intravenous antibiotics. Read More

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A Case of Annular Epidermolytic Ichthyosis Resulting from a de Novo Mutation, p.I479T, in Gene.

Indian J Dermatol 2021 Mar-Apr;66(2):224

Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

We report a case of annular epidermolytic ichthyosis (AEI) resulting from gene mutation. AEI is a rare autosomal dominantly inherited cornification disorder and is a distinct phenotypic variant of bullous congenital ichthyosiform erythroderma. Blisters and erosions in AEI are widespread; hence, initially, it is sometimes mistaken with epidermolysis bullosa, acrodermatitis enteropathica, and staphylococcal scalded skin syndrome. Read More

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50 Years Ago in TheJournalofPediatrics: The Baptism of Staphylococcal Scalded Skin Syndrome: Old is Gold.

J Pediatr 2021 06;233:81

Department of Pediatrics, University College of Medical Sciences, Delhi, India.

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Demographic characteristics, clinical features, and optimal management of hospitalized patients with staphylococcal scalded skin syndrome.

Pediatr Dermatol 2021 Jul 18;38(4):825-830. Epub 2021 May 18.

Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.

Background/objectives: Optimal management of staphylococcal scalded skin syndrome (SSSS) has not been established. Clindamycin may benefit patients via inhibition of ribosomal toxin production, but resistance patterns suggest penicillinase-resistant penicillins or cephalosporins should be the first line. Our goal was to describe demographic and clinical characteristics of SSSS patients at our institution, delineate bacterial resistance patterns, and examine outcomes of varying therapeutic strategies in SSSS. Read More

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Antibiotic Regimens and Associated Outcomes in Children Hospitalized With Staphylococcal Scalded Skin Syndrome.

J Hosp Med 2021 03;16(3):149-155

Section of Pediatric Hospital Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: Controversy exists regarding the optimal antibiotic regimen for use in hospitalized children with staphylococcal scalded skin syndrome (SSSS). Various regimens may confer toxin suppression and/or additional coverage for methicillin-susceptible Staphylococcus aureus (MSSA) or methicillin-resistant S aureus (MRSA).

Objectives: To describe antibiotic regimens in hospitalized children with SSSS and examine the association between antistaphylococcal antibiotic regimens and patient outcomes. Read More

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Complete Genome Sequence of Exfoliative Toxin-Producing Staphylococcus aureus Strain MSSA_SSSS_01, Obtained from a Case of Staphylococcal Scalded-Skin Syndrome.

Microbiol Resour Announc 2021 Feb 11;10(6). Epub 2021 Feb 11.

Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA

Here, we announce the complete genome sequence of an exfoliative toxin-producing strain of sequence type 582 (ST582), isolated from a case of staphylococcal scalded-skin syndrome. The genome consists of a single circularized unitig with a total length of 2,792,190 bp carrying 2,699 genes. The genome is the basis for future epidemiological and genomic studies. Read More

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February 2021

Antimicrobial Resistance and Molecular Analysis of in Staphylococcal Scalded Skin Syndrome among Children in Korea.

J Korean Med Sci 2021 Jan 18;36(3):e22. Epub 2021 Jan 18.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Background: Staphylococcal scalded skin syndrome (SSSS) is a skin disease characterized by blistering and desquamation caused by exfoliative toxins (ETs) of (). Although many countries show predominance of methicillin-susceptible (MSSA), cases of methicillin-resistant (MRSA) have been reported.

Methods: Twenty-six children aged <15 years diagnosed with SSSS from January 2010 to December 2017 from three hospitals were included. Read More

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January 2021

Staphylococcal scalded skin syndrome: An epidemiological and clinical review of 84 cases.

Pediatr Dermatol 2021 Jan 1;38(1):149-153. Epub 2020 Dec 1.

Division of Pediatric Medicine, Section of Dermatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Background: Staphylococcal scalded skin syndrome (SSSS) is a toxin-mediated, blistering skin disorder that mainly affects infants and children. There is limited literature regarding pediatric SSSS. The purpose of this study was to describe the epidemiology, clinical features, and management of pediatric SSSS. Read More

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January 2021

Kawasaki disease mimickers.

Pediatr Int 2021 Aug 16;63(8):880-888. Epub 2021 Jul 16.

Clinical Immunology Department, Instituto Nacional de Pediatría, Mexico City, Mexico.

Background: Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects patients younger than 5 years. In the absence of an available, affordable diagnostic test, detailed clinical history and physical examination are still fundamental to make a diagnosis.

Methods: We present five representative cases with KD-like presentations: systemic onset juvenile idiopathic arthritis, mycoplasma-induced rash and mucositis, staphylococcal scalded skin syndrome, BCGosis, and the recently described multisystemic inflammatory syndrome in children (MIS-C) associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus. Read More

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Comparison of adult vs. paediatric inpatients with staphylococcal scalded skin syndrome: a retrospective database analysis.

Br J Dermatol 2021 04 1;184(4):767-769. Epub 2021 Feb 1.

Department of Dermatology, Rutgers New Jersey Medical School, Newark, NJ, USA.

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Perinatal chikungunya induced scalded skin syndrome.

IDCases 2020 25;22:e00969. Epub 2020 Sep 25.

Center for Clinical Studies, Webster, TX, United States.

Chikungunya is a rapidly emerging infectious disease worldwide caused by a virus that belongs to the Togaviridae family. It can have varied presentations, but vesiculobullous lesions are commonly described. A widespread dissemination of such lesions, however, is extremely rare. Read More

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September 2020

Staphylococcal scalded-skin syndrome in preterm infants: A case report.

Australas J Dermatol 2021 Feb 13;62(1):e129-e130. Epub 2020 Jul 13.

Division of Neonatology, Department of Pediatrics, Fondazione Policlinico "A. Gemelli" IRCCS, Catholic University of the Sacred Heart, Rome, Italy.

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February 2021

Vancomycin for severe staphylococcal scalded skin syndrome.

J Paediatr Child Health 2021 May 28;57(5):747-748. Epub 2020 Jun 28.

Department of Paediatrics, Asahi General Hospital, Chiba, Japan.

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Synergistic antimicrobial activity of melittin with clindamycin on the expression of encoding exfoliative toxin in Staphylococcus aureus.

Toxicon 2020 Aug 22;183:11-19. Epub 2020 May 22.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus is an opportunistic human pathogens, with the ability to produce a series of virulence factors that contribute to the severity of infections. Exfoliative toxins (ETs) are one of the important virulence factors that participating in staphylococcal scalded skin syndrome. Melittin has different biological activities, comprising of antiviral, broad spectrum antibacterial, antiprotozoal, antifungal and anti-inflammatory effects. Read More

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The Role of Gram Staining in Staphylococcal Scalded Skin Syndrome.

Cureus 2020 Apr 10;12(4):e7624. Epub 2020 Apr 10.

Medicine, Universidad Anáhuac Mexico, Mexico City, MEX.

Staphylococcal scalded skin syndrome (SSSS) is a severe blistering disease common in children. The diagnosis of SSSS is often difficult to distinguish from other blistering diseases in children. Here, we report a case of SSSS with a particular diagnostic step to elucidate the disease, which is the Gram stain. Read More

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Clindamycin induced toxic epidermal necrolysis versus Staphylococcal scalded skin syndrome: a case report.

Oxf Med Case Reports 2020 Mar 6;2020(3):omaa020. Epub 2020 May 6.

National University of Ireland, Galway, Ireland.

Toxic epidermal necrolysis and Staphylococcal scalded skin syndrome (SSSS) are potentially life-threatening dermatological emergencies that present in a similar clinical fashion. Toxic epidermal necrolysis is typically triggered by anticonvulsant and other neurological medications and reports clindamycin inducing the disease is exceedingly rare. SSSS seldomly occurs in adult patients. Read More

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Pediatric dermatology emergencies.

Cutis 2020 03;105(3):132-136

Division of Dermatology, Loyola University Medical Center, Maywood, Illinois, USA.

Many pediatric skin conditions can be safely monitored with minimal intervention, but certain skin conditions are emergent and require immediate attention and proper assessment of the neonate, infant, or child. We review the following pediatric dermatology emergencies so that clinicians can detect and accurately diagnose these conditions to avoid delayed treatment and considerable morbidity and mortality if missed: staphylococcal scalded skin syndrome (SSSS), impetigo, eczema herpeticum (EH), Langerhans cell histiocytosis (LCH), infantile hemangioma (IH), and IgA vasculitis. Read More

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