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    553 results match your criteria Staphylococcal Scalded Skin Syndrome

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    Rapid containment of nosocomial transmission of a rare community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone, responsible for the Staphylococcal Scalded Skin Syndrome (SSSS).
    Ital J Pediatr 2017 Jan 6;43(1). Epub 2017 Jan 6.
    MMARLab - Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Via Santa Sofia 97, 95123, Catania, Italy.
    Background: The aims of this study were to identify the source and the transmission pathway for a Staphylococcal Scalded Skin Syndrome (SSSS) outbreak in a maternity setting in Italy over 2 months, during 2014; to implement appropriate control measures in order to prevent the epidemic spread within the maternity ward; and to identify the Methicillin-Resistant Staphylococcus aureus (MRSA) epidemic clone.

    Methods: Epidemiological and microbiological investigations, based on phenotyping and genotyping methods, were performed. All neonates involved in the outbreak underwent clinical and microbiological investigations to detect the cause of illness. Read More

    A Systemic Review on Staphylococcal Scalded Skin Syndrome (SSSS): A Rare and Critical Disease of Neonates.
    Open Microbiol J 2016 31;10:150-9. Epub 2016 Aug 31.
    Central Facility of Instrumentation, Faculty of Pharmacy, IFTM University, Moradabad, UP, 244102, India.
    The symptoms of Staphylococcal scalded skin syndrome (SSSS) include blistering of skin on superficial layers due to the exfoliative toxins released from Staphylococcus aureus. After the acute exfoliation of skin surface, erythematous cellulitis occurs. The SSSS may be confined to few blisters localized to the infection site and spread to severe exfoliation affecting complete body. Read More

    Demographic and clinical characteristics and risk factors for Staphylococcal scalded skin syndrome in Hunan.
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2016 Apr;41(4):417-21
    Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To realize the risk factors, clinical features, and treatments of Staphylococcal scalded skin syndrome (SSSS).

    Methods: The clinical features, laboratory findings, and treatment were retrospectively analyzed in 290 patients from Hunan Children's Hospital.

    Results: Of the 290 patients, less than 3 years old children were 76. Read More

    Severe case of staphylococcal scalded skin syndrome in a 5-year-old child - case report.
    Clin Case Rep 2016 Apr 12;4(4):416-9. Epub 2016 Mar 12.
    Department of Plastic Surgery, Breast Surgery and Burns Treatment Rigshospitalet, University of Copenhagen Copenhagen Denmark.
    Benign impetigo can progress into a potential fatal staphylococcal scalded skin syndrome (SSSS) if prompt diagnosis and correct therapy is not established rapidly. Local and systematic antibiotics as well as Lactulose are crucial in order to stop SSSS from progressing. Burns units should be involved when skin lesions are extensive. Read More

    Use of the frozen section 'jelly-roll' technique to aid in the diagnosis of bullous congenital ichthyosiform erythroderma (epidermolytic hyperkeratosis).
    J Cutan Pathol 2016 May 4;43(5):434-7. Epub 2016 Apr 4.
    Department of Dermatology, Wilford Hall Ambulatory Surgical Center, Lackland AFB, TX, USA.
    Frozen section is a valuable tool that is often underutilized in the setting of in-patient dermatology. Traditionally, frozen section has been used in dermatology to diagnose toxic epidermal necrolysis, with some additional utility in staphylococcal scalded skin syndrome in the new born period. We report a newborn female with ruptured bullae on the face, chest, back and extremities with a clinical differential diagnosis that included staphylococcal scalded skin, bullous congenital ichthyosiform erythroderma/epidermolytic hyperkeratosis and epidermolysis bullosa. Read More

    Draft Genome Sequences of Exfoliative Toxin A-Producing Staphylococcus aureus Strains B-7772 and B-7777 (CC8/ST2993) and B-7774 (CC15/ST2126), Isolated in a Maternity Hospital in the Central Federal District of Russia.
    Genome Announc 2016 Mar 3;4(2). Epub 2016 Mar 3.
    State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia.
    Staphylococcus aureus clonal complex 8 (CC8) has not been associated with staphylococcal scalded-skin syndrome (SSSS) in newborns and exfoliative toxin genes. Here, we report the draft genome sequences of exfoliative toxin A-producing B-7772, B-7777 (both CC8), and B-7774 (CC15) strains associated with SSSS in newborns. Read More

    Variation among Staphylococcus aureus membrane vesicle proteomes affects cytotoxicity of host cells.
    Microb Pathog 2016 Apr 27;93:185-93. Epub 2016 Feb 27.
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Republic of Korea. Electronic address:
    Staphylococcus aureus secretes membrane-derived vesicles (MVs), which can deliver virulence factors to host cells and induce cytopathology. However, the cytopathology of host cells induced by MVs derived from different S. aureus strains has not yet been characterized. Read More

    [Staphylococcal Scalded Skin Syndrome in a Very Low Birth Weight Premature Infant].
    Z Geburtshilfe Neonatol 2016 Feb 11;220(1):35-8. Epub 2016 Feb 11.
    Neonatologie, Kinderklinik und Poliklinik, Würzburg.
    Introduction: Staphylococcal scalded skin syndrome (SSSS) was often endemic in the past but is nowadays rare. The hematogeneous spread of exfoliative toxins A (ETA) or B (ETB) produced by specific Staphylococcus aureus strains causes a scald-like eruption with disseminated bullous lesions.

    Case Report: A perioral impetigo lesion occurred on day 14 of life in a preterm male infant (1,065 g, 30 weeks of gestational age). Read More

    Epidermal exfoliation of over 95% after a burn in an 18-month-old boy: Case report and review of the literature.
    Burns 2016 Mar 20;42(2):e18-23. Epub 2016 Jan 20.
    Burn Center, Department of Plastic- and Maxillofacial Surgery, Uppsala University Hospital, 751 85 Uppsala, Sweden; Department of Surgical Sciences, Plastic Surgery, Uppsala University, 751 85 Uppsala, Sweden. Electronic address:
    This report concerns an 18-month-old boy who presented with a 6% total body surface area scald. The subject of this report is unique in that he developed the largest exfoliation described in literature. After 3 days an epidermal exfoliation with the appearance of a deliberately inflicted scald developed. Read More

    Skin biopsy: Biopsy issues in specific diseases.
    J Am Acad Dermatol 2016 Jan;74(1):1-16; quiz 17-8
    Department of Dermatology, Johns Hopkins Hospital, Baltimore, Maryland.
    Misdiagnosis may result from biopsy site selection, technique, or choice of transport media. Important potential sources of error include false-negative direct immunofluorescence results based on poor site selection, uninformative biopsy specimens based on both site selection and technique, and spurious interpretations of pigmented lesions and nonmelanoma skin cancer based on biopsy technique. Part I of this 2-part continuing medical education article addresses common pitfalls involving site selection and biopsy technique in the diagnosis of bullous diseases, vasculitis, panniculitis, connective tissue diseases, drug eruptions, graft-versus-host disease, staphylococcal scalded skin syndrome, hair disorders, and neoplastic disorders. Read More

    Staphylococcal scalded skin syndrome in a premature newborn caused by methicillin-resistant Staphylococcus aureus: case report.
    Sao Paulo Med J 2015 Sep-Oct;133(5):450-3. Epub 2015 Mar 17.
    Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brasil.
    Context: Staphylococcal scalded skin syndrome is an exfoliative skin disease. Reports of this syndrome in newborns caused by methicillin-resistant Staphylococcus aureus are rare but, when present, rapid diagnosis and treatment is required in order to decrease morbidity and mortality.

    Case Report: A premature newly born girl weighing 1,520 g, born with a gestational age of 29 weeks and 4 days, developed staphylococcal scalded skin syndrome on the fifth day of life. Read More

    Staphylococcal Scalded Skin Syndrome in Neonate.
    Case Rep Dermatol Med 2015 8;2015:901968. Epub 2015 Jun 8.
    Department of Dermatology and Infectiology, Training and Research Unit of Medical Sciences, Felix Houphouët Boigny University of Abidjan, BP 5151, Abidjan 21, Côte d'Ivoire.
    We described a case of Staphylococcal Scalded Skin Syndrome in infant age of 21 days by discussing clinical and management issues. This newborn presented large erythematous, eroded, and oozing areas covered by epidermal skin flap. The average surface of cutaneous unsticking on admission was 31. Read More

    Effective Treatment of Staphylococcal Scalded Skin Syndrome with Platelet Microbicidal Protein in CBRB-Rb(8.17)1Iem Mice Model.
    Probiotics Antimicrob Proteins 2015 Sep;7(3):203-6
    All-Russian Institute of Meat Cattle Breeding, Russian Academy of Agricultural Sciences, Orenburg, Russia.
    Skin and soft-tissue infections are among the most common infections. Staphylococcus aureus may cause a number of toxin-mediated diseases, including staphylococcal scalded skin syndrome (SSSS). The therapeutic efficacy of some antimicrobial peptides was recently evaluated in a mouse model of SSSS. Read More

    Recent developments in the management of common childhood skin infections.
    J Infect 2015 Jun 29;71 Suppl 1:S76-9. Epub 2015 Apr 29.
    Sint Franciscus Vlietland Group, Vlietland Hospital, Schiedam, The Netherlands.
    A literature review and clinical commentary on diagnosis and treatment of common childhood bacterial, fungal and viral skin infections is presented including impetigo, folliculitis, staphylococcal scalded skin syndrome, tinea capitis, warts and molluscum contagiosum. Read More

    Staphylococcal scalded skin syndrome in a premature newborn caused by methicillin-resistant Staphylococcus aureus: case report.
    Sao Paulo Med J 2015 Mar 17. Epub 2015 Mar 17.
    Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
    Context: Staphylococcal scalded skin syndrome is an exfoliative skin disease. Reports of this syndrome in newborns caused by methicillin-resistant Staphylococcus aureus are rare but, when present, rapid diagnosis and treatment is required in order to decrease morbidity and mortality.

    Case Report: A premature newly born girl weighing 1,520 g, born with a gestational age of 29 weeks and 4 days, developed staphylococcal scalded skin syndrome on the fifth day of life. Read More

    A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography.
    Skin Res Technol 2015 Aug 12;21(3):363-5. Epub 2015 Jan 12.
    Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark.
    Background: Staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) both present with acute onset, high morbidity and significant mortality. Rapid diagnosis is therefore of importance. The aim of this study was to investigate and compare the presentation of these diseases using optical coherence tomography (OCT). Read More

    [Clindamycin as adjuvant therapy in Staphilococcal skin scalded syndrome].
    An Sist Sanit Navar 2014 Sep-Dec;37(3):449-53
    Servicio de Pediatría, Hospital García Orcoyen, Estella, 31200, Spain.
    Staphylococcal scalded skin syndrome (SSSS) is a dermatologic disease caused by exotoxins produced by Staphylococcus aureus. The disease presents as a painful cutaneous rash that culminates with the detachment of the superficial dermis. The usual treatment is antibiotics with beta-lactamase resistant penicillin. Read More

    Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants.
    Eur J Pediatr 2015 Apr 7;174(4):551-5. Epub 2014 Sep 7.
    Department of Pediatrics Shinshu, University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan,
    Unlabelled: Staphylococcal scalded skin syndrome (SSSS) demonstrates dermal symptoms due to exfoliative toxin (ET) A or ETB produced by Staphylococcus aureus. We examined the association between anti-ETA antibodies and SSSS onset in neonates. Three preterm infants carried an ETA-producing strain of S. Read More

    Nosocomial outbreak of staphyloccocal scalded skin syndrome in neonates in England, December 2012 to March 2013.
    Euro Surveill 2014 Aug 21;19(33). Epub 2014 Aug 21.
    Public Health England, East Midlands Public Health England Centre, Leicester, United Kingdom.
    Staphylococcal scalded skin syndrome (SSSS) is a blistering skin condition caused by exfoliative toxin-producing strains of Staphylococcus aureus. Outbreaks of SSSS in maternity settings are rarely reported. We describe an outbreak of SSSS that occurred among neonates born at a maternity unit in England during December 2012 to March 2013. Read More

    A review of important skin disorders occurring in the posttransplantation patient.
    Adv Anat Pathol 2014 Sep;21(5):321-9
    Departments of *Pathology †Dermatology, Stanford University Medical Center, Stanford, CA.
    Hematopoietic stem cell transplantation continues to be the mainstay of treatment for many hematologic dyscrasias and malignancies, including acute leukemias, lymphomas, and aplastic anemia. There can be significant complications, however, and often these complications are manifested in the skin as an eruption. Common among these are acute and chronic graft-versus-host disease, erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis, eruption of lymphocyte recovery, staphylococcal scalded skin syndrome, morbiliform drug eruptions, infections, and toxic erythema of chemotherapy. Read More

    Staphylococcal Scalded Skin Syndrome in an Adult on Chemotherapy.
    Dermatopathology (Basel) 2014 Aug-Dec;1(2):75-80. Epub 2014 Oct 31.
    Program in Dermatopathology, Department of Pathology, Boston, Mass., USA.
    Staphylococcal scalded skin syndrome is a toxin-mediated, epidermolytic condition that uncommonly affects adults. A 51-year-old man receiving chemotherapy for leukemia presented with a large geographic erosion with superficial sloughing and multiple smaller lesions elsewhere. Biopsy revealed complete subcorneal splitting with multiple detached fragments of normal-appearing stratum corneum with fragments of attached acantholytic granular keratinocytes. Read More

    Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
    J Eur Acad Dermatol Venereol 2014 Nov 20;28(11):1418-23. Epub 2014 May 20.
    Department of Dermatology, Rutgers University New Jersey Medical School, Newark, USA.
    Staphylococcal scalded skin syndrome is a potentially life-threatening disorder caused most often by a phage group II Staphylococcus aureus infection. Staphylococcal scalded skin syndrome is more common in newborns than in adults. Staphylococcal scalded skin syndrome tends to appear abruptly with diffuse erythema and fever. Read More

    From erythema multiforme to toxic epidermal necrolysis. Same spectrum or different diseases?
    G Ital Dermatol Venereol 2014 Apr;149(2):243-61
    Dermatopathology Section, Department of Medical Sciences University of Turin, Turin, Italy -
    Erythema multiforme (EM), Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute bullous disorders associated to different prognosis, mainly due to infections and drugs. More in particular EM in more than 90% is caused by infections (especially Herpes virus infection), while, on the other hand SJS and TEN are referable in more than 95% of cases to drugs. Distinction among these three forms is often controversal and still debated. Read More

    Keratinocytes produce IL-6 in response to desmoglein 1 cleavage by Staphylococcus aureus exfoliative toxin A.
    Immunol Res 2013 Dec;57(1-3):258-67
    Department of Microbiology and Immunology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
    Many skin infections are caused by Staphylococcus aureus, a bacterial pathogen that produces virulence factors associated with these conditions such as exfoliative toxins A and B (ETA, ETB) and the leukotoxin Panton-Valentine leukocidin (PVL). Herein, we examine the potential of skin-infecting S. aureus to produce virulence factors and their impact on the local immune response. Read More

    Emergence of Staphylococcus aureus carrying multiple drug resistance genes on a plasmid encoding exfoliative toxin B.
    Antimicrob Agents Chemother 2013 Dec 30;57(12):6131-40. Epub 2013 Sep 30.
    Department of Bacteriology, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima City, Hiroshima, Japan.
    We report the complete nucleotide sequence and analysis of pETBTY825, a Staphylococcus aureus TY825 plasmid encoding exfoliative toxin B (ETB). S. aureus TY825 is a clinical isolate obtained from an impetigo patient in 2002. Read More

    Antibiotic sensitivity and resistance patterns in pediatric staphylococcal scalded skin syndrome.
    Pediatr Dermatol 2014 May-Jun;31(3):305-8. Epub 2013 Aug 23.
    Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
    Historical resistance patterns often guide empiric antibiotic choices in staphylococcal scalded skin syndrome (SSSS), but little is known about the difference in susceptibility between SSSS and other childhood staphylococcal infections. A retrospective chart review of culture-confirmed cases of SSSS seen in the inpatient dermatology consultation service at the Children's Hospital of Philadelphia between 2005 and 2011 was performed. Most cases of SSSS at our institution are due to oxacillin-susceptible Staphylococcus aureus, and approximately half of the cases are due to clindamycin-resistant strains. Read More

    Toxic epidermal necrolysis: Part II. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment.
    J Am Acad Dermatol 2013 Aug;69(2):187.e1-16; quiz 203-4
    Dermatology, Preventive Medicine, and Pathology, Rutgers University New Jersey Medical School, Newark, New Jersey 07103-2714, USA.
    Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced, mucocutaneous disease. TEN has a high mortality rate, making early diagnosis and treatment of paramount importance. New but experimental diagnostic tools that measure serum granulysin and high-mobility group protein B1 (HMGB1) offer the potential to differentiate early TEN from other, less serious drug reactions, but these tests have not been validated and are not readily available. Read More

    [Staphylococcal scalded skin syndrome associated with long-term catherter related infection in an adult].
    Kansenshogaku Zasshi 2013 May;87(3):380-4
    Disease Control Prevention Center, National Center for Global Health and Medicine.
    Staphylococcal scalded skin syndrome (SSSS) is an extensive desquamative erythmatous condition caused by the Staphylococcus aureus exfoliative toxin. Although adult cases of SSSS are rare, the mortality rate is high. We report herein on a case of SSSS due to long-term catheter-related bloodstream infection caused by exfoliative toxin B, which produced methicillin-resistant Staphylococcus aureus. Read More

    Staphylococcal scalded skin syndrome in neonates: an 8-year retrospective study in a single institution.
    Pediatr Dermatol 2014 Jan-Feb;31(1):43-7. Epub 2013 Apr 5.
    Children's Hospital of Chongqing Medical University, Chongqing, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
    Staphylococcal scalded skin syndrome (SSSS) is a rare disorder in children. Complications may occur without timely treatment. Mortality in children with SSSS is approximately 4%. Read More

    Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities.
    PLoS One 2013 7;8(3):e58155. Epub 2013 Mar 7.
    Robert Koch Institute, Wernigerode, Germany.
    We investigated the population structure of Staphylococcus aureus clonal complex CC121 by mutation discovery at 115 genetic housekeeping loci from each of 154 isolates, sampled on five continents between 1953 and 2009. In addition, we pyro-sequenced the genomes from ten representative isolates. The genome-wide SNPs that were ascertained revealed the evolutionary history of CC121, indicating at least six major clades (A to F) within the clonal complex and dating its most recent common ancestor to the pre-antibiotic era. Read More

    [Acute skin detachment in a newborn].
    Ned Tijdschr Geneeskd 2013 ;157(11):A5272
    UMC Groningen, afd. Dermatologie, Centrum voor blaarziekten, Groningen, the Netherlands.
    Acute blistering and erosion in a newborn is one of the few emergency cases seen in dermatology. It is important to differentiate between infectious causes, congenital abnormalities, autoimmune bullous dermatitis, immunological skin diseases and skin burns within 24 hours. In this clinical lesson, we present a case of acute skin detachment in a newborn caused by staphylococcal scalded skin syndrome (SSSS). Read More

    Staphylococcal scalded skin syndrome due to burn wound infection.
    Ann Burns Fire Disasters 2012 Sep;25(3):140-2
    St Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, United Kingdom.
    Unlabelled: Introduction. The staphylococcal scalded skin syndrome is an acute exfoliation of the skin caused by exfoliative toxins A and B. Although Staphylococcus aureus is a common cause of burn wound infection, SSSS following burn wound infection is rare. Read More

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