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Foodborne Pathog Dis 2019 Apr 19. Epub 2019 Apr 19.

2 Bacterial Epidemiology and Antimicrobial Resistance Research Unit, USDA-ARS, U.S. National Poultry Research Center, Athens, Georgia.

Eggs are a healthy and nutritious food source, but may be contaminated by bacteria. Previous studies have reported the presence of staphylococci in eggs of farmed chickens, but no study has evaluated the staphylococcal population of eggs from household chickens. In this study, staphylococci from eggs ( = 275) of household chickens collected from November 2016 to March 2017 from different villages of Khyber Pakhtunkhwa province, Pakistan, were characterized. Read More

Front Microbiol 2019 2;10:641. Epub 2019 Apr 2.

Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou, China.

is one of the most important food-borne pathogens globally. It produces various toxins and invasive enzymes and can be found in numerous food products. Milk is an important source of staphylococcal food poisoning. Read More

Sci Rep 2019 Apr 17;9(1):6203. Epub 2019 Apr 17.

Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States.

Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease burden areas. However, diagnosing bacteremia is challenging for clinicians, especially in children presenting with co-infections such as malaria and HIV. Read More

Dermatology 2019 Apr 17:1-11. Epub 2019 Apr 17.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The most frequent S. aureus infections include impetigo, folliculitis, furuncles, furunculosis, abscesses, hidradenitis suppurativa, and mastitis. Read More

Ren Fail 2019 Nov;41(1):303-313

b Inkosi Albert Luthuli Central Hospital , Durban , South Africa.

Introduction: Staphylococcal infections can cause significant morbidity in patients undergoing dialysis. This study evaluated the effects of HIV infection on nasal carriage of Staphylococcus aureus, staphylococcal peritonitis, and catheter infection rates in patients with end-stage renal failure managed with continuous ambulatory peritoneal dialysis (CAPD).

Methods: Sixty HIV-positive and 59 HIV-negative CAPD patients were enrolled and followed up for up to 18 months. Read More

J Infus Nurs 2019 May/Jun;42(3):125-131

Nebraska Antimicrobial Stewardship Assessment and Promotion Program, Nebraska Infection Control Assessment and Promotion Program, and Nebraska Medicine, Omaha, Nebraska (Dr Nailon); Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska (Dr Rupp); and College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska (Ms Lyden). Regina E. Nailon, PhD, RN, facilitates interprofessional research and meaningful use of data in clinical decision making at Nebraska Medicine. Her primary research focus is aimed at improving health outcomes and the infrastructure necessary for the delivery of safe and appropriate care across the care continuum. Mark E. Rupp, MD, is professor and chief of the Division of Infectious Diseases at the University of Nebraska Medical Center. He is also the medical director of the Department of Infection Control and Epidemiology. Dr Rupp studies device-associated infections, staphylococcal disease, and antimicrobial stewardship. Elizabeth Lyden, MS, is associate director of the Center for Collaboration on Research, Design and Analysis, and an instructor in the Department of Biostatistics at the University of Nebraska Medical Center. She provides consultation, data analysis, and manuscript preparation in multiple departments including infectious diseases.

Patients are increasingly receiving therapy at home via central vascular access devices (CVADs). Limited data exist regarding patients' experiences with outpatient CVADs. This study characterized outpatient CVAD care via 14-day patient diaries. Read More

Infect Dis (Lond) 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Department of Infectious Diseases , Singapore General Hospital , Singapore.

Background: Left ventricular assist device (LVAD) associated infections (LVADIs) have substantial morbidity and mortality. We aim to describe the incidence and epidemiology of LVADIs in an Asian cohort. This is currently not well studied. Read More

Biotechnol Bioeng 2019 Apr 14. Epub 2019 Apr 14.

CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.

Detection and capture methods using antibodies have been developed to ensure identification of pathogens in biological samples. Though antibodies have many attractive properties, they also have limitations and there are needs to expand the panel of available affinity proteins with different properties. Affitins, that we developed from the Sul7d proteins, are a solid class of affinity proteins which can be used as substitutes to antibodies or to complement them. Read More

Clin Infect Dis 2019 Apr 13. Epub 2019 Apr 13.

Division of Infectious Diseases, Henry Ford Health System, Detroit, Michigan.

Background: The impact of healthcare personnel hand contamination in multidrug-resistant organism (MDRO) transmission is important and well studied; however, the role of patient hand contamination needs to be characterized further.

Methods: Patients from 2 hospitals in southeast Michigan were recruited within 24 hours of arrival to their room and followed prospectively using microbial surveillance of nares, dominant hand, and 6 high-touch environmental surfaces. Sampling was performed on admission, days 3 and 7, and weekly until discharge. Read More

Am J Transl Res 2019 15;11(3):1270-1281. Epub 2019 Mar 15.

Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University Nanning, China.

It is important to improve the existing techniques and develop new strategies to prevent bacterial biofilm formation. In this in vitro study, biofilms were established by a clinically isolated strain of 17546 (t037). Different concentrations of baicalin were added to 3- and 7-day biofilms. Read More

Front Immunol 2019 26;10:595. Epub 2019 Mar 26.

University of Colorado Denver Anschutz Medical Center, Aurora, CO, United States.

HIV-exposed uninfected infants (HEU) are at higher risk of severe infections, hospitalizations and death compared with HIV-unexposed uninfected infants (HUU), but the immune deficit underlying it is not known. To address this gap, we investigated T cell functionality and its relationship to phenotypic profiles of T cells and antigen presenting cells (APC) in HEU and HUU. Blood mononuclear cells from 55 HEU and 16 HUU were stimulated with Staphylococcal Enterotoxin B (SEB) or mock for 72 h, and tested by flow cytometry for proliferation and expression of Th1, Th2, and regulatory (Treg) markers. Read More

Asian Spine J 2019 Apr 2. Epub 2019 Apr 2.

Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, India.

Study Design: Prospective clinical study.

Purpose: We evaluated the challenges faced during diagnosis and management of patients with subacute pyogenic discitis and discussed various clues in clinical history, radiologic and hematologic parameters of these patients that helped in establishing their diagnosis.

Overview Of Literature: Present literature available shows that in patients with subacute spondylodiscitis and infection with less virulent organisms, the clinical picture often is confusing and the initial radiologic and hematologic studies do not contribute much toward establishing the diagnosis. Read More

Chemotherapy 2019 Apr 9;63(6):345-351. Epub 2019 Apr 9.

University of Minnesota College of Pharmacy, Minneapolis, Minnesota, USA,

Background: Antistaphylococcal penicillins have historically been regarded as the drugs of choice for methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSI). However, recent outcomes data compared to cefazolin treatment are conflicting.

Objective: This study compared treatment failure and adverse effects associated with nafcillin and cefazolin for MSSA BSI. Read More

Heart Lung Circ 2019 Feb 1. Epub 2019 Feb 1.

Department of Infectious Diseases, Alfred Hospital, Melbourne, Vic, Australia.

Background Infective endocarditis has been associated with underlying cardiac pathology and streptococci infections. Intravenous drug use (IVDU) is increasingly implicated as a contributing factor, resulting in a shift to a younger patient demographic, tricuspid valve involvement, severe staphylococcal infection, and unique management challenges. The objective of this study was to describe the clinical features, management and outcomes of patients with IVDU-associated infective endocarditis in the Australian context. Read More

Int J Antimicrob Agents 2019 Apr 4. Epub 2019 Apr 4.

Division of Microbiology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Janakipuram Extension, Lucknow-226031, Uttar Pradesh, India. Electronic address:

Background: Antimicrobial resistance is an urgent threat affecting healthcare systems worldwide. Identification of novel molecules capable of escaping current resistance mechanism and exhibiting potent activity against highly drug-resistant strains is the unmet need of the hour.

Methods: Whole cell growth inhibition assays were used to screen and identify novel inhibitors. Read More

Arch Pediatr 2019 Apr 3. Epub 2019 Apr 3.

Équipe « Pathogénèse des infections à Staphylocoques », Inserm U1111, centre international de recherche en infectiologie, 46, allée d'Italie, 69364 Lyon cedex 07, France; Centre national de référence des staphylocoques, groupement hospitalier est, hospices civils de Lyon, Institut des agents infectieux, 59, boulevard Pinel, 69677 Bron cedex, France.

Heteroresistance to vancomycin (HRV) represents a decreased susceptibility to vancomycin and is frequently observed in multidrug-resistant coagulase-negative staphylococci. The clinical significance of such heteroresistance is controversial, but several failures of vancomycin therapy have been related to HRV, especially in the neonatal population. Here we report the case of a preterm neonate, born at 26 weeks of gestation, who developed sepsis due to a multidrug-resistant HRV Staphylococcuscapitis isolate. Read More

Open Forum Infect Dis 2019 Apr 21;6(4):ofz062. Epub 2019 Mar 21.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Hospitalized neonates are at high risk for invasive infections. nasal colonization often precedes infection. The nasal microbiota may preclude or support colonization. Read More

J Vet Sci 2019 Mar 8;20(2):e6. Epub 2019 Mar 8.

Department of Animal Science and Technology, School of Bioresources and Bioscience, Chung-Ang University, Anseong 17546, Korea.

The recent emergence of in dogs with otitis externa or skin and soft tissue infections has become a significant zoonotic issues. In the current study, we investigated 1) the carriage rates of among major staphylococci in healthy dogs and dogs with otitis externa, 2) antibiotic susceptibility profiles of particularly methicillin resistance (MR), and 3) virulence factors associated with skin and soft tissue infections such as ability to form biofilm, resistance to cationic antimicrobial peptides (CAMPs), and carriage of staphylococcal enterotoxin genes. Among the 21 isolates, 5 isolates (24%) were determined to be methicillin-resistant (MRSS). Read More

BMC Infect Dis 2019 Apr 3;19(1):302. Epub 2019 Apr 3.

Department of Infection, Immunity and Inflammation, Institut Cochin, INSERM U1016, Paris, EU, France.

Background: Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphylococcal illness may be a consequence of both microbial factors and variability of the host immune response.

Case Presentation: A 14-years old child developed limb ischemia with gangrene following S. Read More

Euro Surveill 2019 Mar;24(13)

Authors contributed equally to the work and share last authorship.

Background: In 2015, Bristol (South West England) experienced a large increase in cases of meticillin-resistant (MRSA) infection in people who inject drugs (PWID).

Aim: We aimed to characterise and estimate the prevalence of MRSA colonisation among PWID in Bristol and test evidence of a clonal outbreak.

Methods: PWID recruited through an unlinked-anonymous community survey during 2016 completed behavioural questionnaires and were screened for MRSA. Read More

Prev Vet Med 2019 May 6;166:78-85. Epub 2019 Mar 6.

Epidemiology Group, National Veterinary Institute, Technical University of Denmark, Kgs. Lyngby, Denmark; Section of Animal Welfare and Disease Control, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, Copenhagen University, Frederiksberg, Denmark.

The objective of this study was to evaluate and compare different combinations of intervention strategies for contagious or opportunistic subclinical and clinical intramammary infections (IMI). We simulated two different Danish dairy cattle herds with ten different intervention strategies focusing on cow-specific treatment or culling, including three baseline strategies without subclinical interventions. In one herd, the main causative pathogen of IMI was Staphylococcus (S. Read More

Cent Eur J Public Health 2019 Mar;27(1):58-63

Clinic for Nephrology, University Clinical Centre of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Objectives: Staphylococcus aureus (SA) represents one of the most important microorganism that is part of the normal microflora of humans, but in certain conditions can cause very serious infections. Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for a wide spectrum of nosocomial and community associated infections worldwide. The aim of this study was to determine community acquired MRSA (CA-MRSA), as well as the frequency of Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome mec (SCCmec) types in isolates obtained from outpatients in the region of 700,000 people (Canton Sarajevo, Bosnia and Herzegovina) Methods: Our investigation included phenotypic and genotypic markers such as antimicrobial resistance, pulsed-field gel electrophoresis (PFGE), SCC typing, and PVL detection. Read More

Microbiol Spectr 2019 03;7(2)

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

has become a serious threat to human health. In addition to having increased antibiotic resistance, the bacterium is a master at adapting to its host by evading almost every facet of the immune system, the so-called immune evasion proteins. Many of these immune evasion proteins target neutrophils, the most important immune cells in clearing infections. Read More

mSphere 2019 03 27;4(2). Epub 2019 Mar 27.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA

is an important canine pathogen implicated in an increasing number of human infections. Along with rising levels of methicillin and multidrug resistance, staphylococcal biofilms are a complicating factor for treatment and contribute to device, implant, and surgical infections. Staphylococcal virulence, including biofilm formation, is regulated in part by the quorum sensing accessory gene regulator system (). Read More

Front Microbiol 2019 12;10:478. Epub 2019 Mar 12.

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

The slow-growing, anaerobic, coagulase-negative species is found on human skin and in clinical specimens but its pathogenic potential is unclear. Here, we investigated clinical isolates and sequenced the genomes of seven strains of . Phylogenomic analyses showed that the closest relative of is with an average nucleotide identity of 80%. Read More

Antimicrob Agents Chemother 2019 Mar 25. Epub 2019 Mar 25.

Department of Pediatrics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Rifampin is active against methicillin-resistant staphylococcal species and tuberculosis (TB). We performed a multicenter, prospective pharmacokinetic (PK) and safety study of intravenous rifampin in infants <121 days postnatal age (PNA). We enrolled 27 infants; the median (range) gestational age was 26 weeks (23-41), and PNA was 10 days (0-84). Read More

Molecules 2019 Mar 22;24(6). Epub 2019 Mar 22.

Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.

The justification for the use of herbal supplements with L. extract (POE) in the case of staphylococcal lung colonization/infections characteristic for cystic fibrosis (CF), was examined in vitro. The impact of POE phenolic-rich fraction on the virulence attributes of CF-associated () clinical strains has been assessed, including pathogen adhesion, biofilm formation on native and protein-conditioned surfaces (mucin, elastin), mature biofilm eradication, staphylococcal protein A expression, α-toxin release, and adhesion to A549 cells. Read More

APMIS 2019 Apr;127(4):181-186

Department of Infection Control and Hygiene, Linköping University Hospital, Linköping, Sweden.

The objective of this study was to investigate a sudden increase in methicillin-resistant Staphylococcus aureus (MRSA) cases primarily in one maternity ward at the Center for Children's and Women's Health at Linköping University Hospital, Sweden. Approximately 300 individuals including patients, their family members, and healthcare workers were screened for MRSA. The antibiotic susceptibility was tested and isolates polymerase chain reaction (PCR)-positive for the mecA gene were spa typed. Read More

Colloids Surf B Biointerfaces 2019 Mar 15;178:377-384. Epub 2019 Mar 15.

Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, 682041, India. Electronic address:

Staphylococcus aureus is a major pathogen causing skin infections and currently treated with topical antibiotic preparations like bacitracin, triple antibiotic ointment (neomycin, polymixin B, and bacitracin), gentamicin or mupirocin. However, their efficacies are restricted when the infections are caused by drug resistant strains. There is an imperative need for new antibacterial compounds for the management of S. Read More

Microbiol Spectr 2019 03;7(2)

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

is capable of becoming resistant to all classes of antibiotics clinically available and resistance can develop through mutations in chromosomal genes or through acquisition of horizontally transferred resistance determinants. This review covers the most important antibiotics available for treatment of infections and a special emphasis is dedicated to the current knowledge of the wide variety of resistance mechanisms that employ to withstand antibiotics. Since resistance development has been inevitable for all currently available antibiotics, new therapies are continuously under development. Read More

World J Microbiol Biotechnol 2019 Mar 21;35(4):57. Epub 2019 Mar 21.

Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Haliç University, 34445, Istanbul, Turkey.

Methicillin-resistant Staphylococcus aureus (MRSA) infections treatment of which is hard and failed, due to being resistant to all types of β-lactams, have been emerged in hospitals and community. Long-term usage of antibiotics and over doses of antibiotics used in the treatment of infections cause bacteria to develop resistance to antibiotics. β-lactams combined with tannic acid can be a good alternative to sensitize the resistance of β-lactams used in the treatment of MRSA, due to their synergistic activities. Read More

Microb Drug Resist 2019 Mar 21. Epub 2019 Mar 21.

2 Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

We investigated the prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among 356 residents of nine long-term care facilities (LTCFs) in Japan during 2015 and 2017. In total, 800 specimens were tested and 39 MRSA isolates were recovered from 31 (8.71%) residents. Read More

MBio 2019 03 19;10(2). Epub 2019 Mar 19.

Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.

Mucosal and skin tissues form barriers to infection by most bacterial pathogens. causes diseases across these barriers in part dependent on the proinflammatory properties of superantigens. We showed, through use of a CRISPR-Cas9 CD40 knockout, that the superantigens toxic shock syndrome toxin 1 (TSST-1) and staphylococcal enterotoxins (SEs) B and C stimulated chemokine production from human vaginal epithelial cells (HVECs) through human CD40. Read More

BMC Complement Altern Med 2019 Mar 19;19(1):70. Epub 2019 Mar 19.

Department of Microbial Biotechnology, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth (Deemed to be) University, Katraj, Pune, 411046, India.

Background: Multi-drug resistance in microorganisms is a serious problem at national as well as at a global level. Many researches have suggested alternatives to antibiotics with minimal or no major side effects. LAB is one of the most human-friendly probiotic strains known to mankind from times immemorial. Read More

Folia Microbiol (Praha) 2019 Mar 19. Epub 2019 Mar 19.

Institute of Food Quality and Food Safety, Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, 30559, Hannover, Germany.

Staphylococcus aureus (S. aureus) is an important causative agent of contagious intermammary infections in dairy cattle. S. Read More

Glob Pediatr Health 2019 7;6:2333794X19833736. Epub 2019 Mar 7.

University of Arkansas for Medical Sciences, Little Rock, AR, USA.

This case report describes an unusual invasive infection with , in a child with a history of repaired congenital heart disease and an acute presentation of osteomyelitis. Coagulase-negative staphylococci are rare causes of osteomyelitis without an implanted device in the bone and, as such, should prompt evaluation for associated infections that may be contributing to the unusual presentation. Additionally, this case highlights the importance of considering methicillin heteroresistance in staphylococcal infections when the clinical course is not proceeding as expected. Read More

Clin Optom (Auckl) 2019 12;11:15-26. Epub 2019 Mar 12.

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: The Antibiotic Resistance Monitoring in Ocular micRoorganisms study is an ongoing surveillance study that tracks antibiotic resistance among bacterial isolates from ocular infections across the United States. We report antibiotic resistance rates and trends from 2009 through 2016.

Materials And Methods: , coagulase-negative staphylococci (CoNS), , , and from various ocular infections were obtained from participating United States centers. Read More

Int J Antimicrob Agents 2019 Mar 14. Epub 2019 Mar 14.

Institute of Translational Research; Laboratory of Infectious Disease Research, Ochsner Clinic Foundation, New Orleans, LA, USA. Electronic address:

Acinetobacter baumannii is an opportunistic pathogen predominantly associated with nosocomial infections. The World Health Organization's data on antibiotic-resistant 'priority pathogens' reports carbapenem-resistant A. baumannii as a pathogen which is in critical need of research and development of new antimicrobials. Read More

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Neonatal Intensive Care Unit, St Mary's Hospital, Manchester, UK.

An ex-30-week gestation, preterm male baby was admitted to a tertiary neonatal unit and noted to have increased ventilator requirements and diagnosed with sepsis. The baby also developed an abscess over the left elbow and over the xiphisternum along with a decrease in movement of the left hand and the right leg. Panton-Valentine leukocidin (PVL)-producing (SA) was isolated from the blood culture. Read More

Arch Orthop Trauma Surg 2019 Mar 15. Epub 2019 Mar 15.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Introduction: This study aimed to (1) report the rates of resistance against a variety of antibiotics for pure Staphylococcal infections, and (2) examine the impact of ALBC use at primary surgery has on resistance patterns for patients undergoing first-time revision of primary hip and knee arthroplasty for indication of infection.

Materials And Methods: Data from the National Joint Registry database for England and Wales were linked to microbiology data held by Public Health England to identify a consecutive series of 258 primary hip and knee arthroplasties performed between April 2003 and January 2014 that went on to have a revision for Staphylococcal deep periprosthetic infection. Multivariate binary logistic regression was used to study predictors of microorganism resistance to a range of antimicrobials. Read More

Clin Microbiol Infect 2019 Mar 11. Epub 2019 Mar 11.

Department of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Denmark.

Background: Staphylococcus argenteus and Staphylococcus schweitzeri, previously known as divergent Staphylococcus aureus clonal lineages, have been recently established as novel, difficult-to-delimit, coagulase-positive species within the S. aureus complex. Methicillin-resistant strains of S. Read More

PLoS Pathog 2019 03 14;15(3):e1007618. Epub 2019 Mar 14.

University of Würzburg, Institute of Molecular Infection Biology, Würzburg, Germany.

RsaE is a conserved small regulatory RNA (sRNA) which was previously reported to represent a riboregulator of central carbon flow and other metabolic pathways in Staphylococcus aureus and Bacillus subtilis. Here we show that RsaE contributes to extracellular (e)DNA release and biofilm-matrix switching towards polysaccharide intercellular adhesin (PIA) production in a hypervariable Staphylococcus epidermidis isolate. Transcriptome analysis through differential RNA sequencing (dRNA-seq) in combination with confocal laser scanning microscopy (CLSM) and reporter gene fusions demonstrate that S. Read More

Methods Mol Biol 2019 ;1954:297-308

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

The world is heading toward a dangerous post-antibiotic era where antibiotics fail to treat infections. Staphylococcus aureus is the leading cause of healthcare-associated infections worldwide, and an ever-increasing percentage of them are methicillin-resistant (MRSA). New strategies are urgently needed to combat this pathogen. Read More

Sci Rep 2019 Mar 12;9(1):4211. Epub 2019 Mar 12.

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.

Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen, which causes superficial to lethal clinical infections. Neutrophils are the most abundant leukocytes in the blood and are the first defense mechanism against S. aureus infections. Read More

Curr Infect Dis Rep 2019 Mar 11;21(4):12. Epub 2019 Mar 11.

Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, 660 S. Euclid Avenue, CB 8116, St. Louis, MO, 63110, USA.

Purpose Of Review: Staphylococcus aureus skin and soft tissue infections (SSTI) are a major source of morbidity. More than half of patients experiencing SSTI will have at least one recurrent infection. These infections frequently cluster in households. Read More

Nat Commun 2019 03 8;10(1):1149. Epub 2019 Mar 8.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8091, Zurich, Switzerland.

Treatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. Read More

Osong Public Health Res Perspect 2019 Feb;10(1):20-24

Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Objectives: The emergence of resistant bacteria is being increasingly reported around the world, potentially threatening millions of lives. Amongst resistant bacteria, methicillin-resistant (MRSA) is the most challenging to treat. This is due to emergent MRSA strains and less effective traditional antibiotic therapies to Staphylococcal infections. Read More

MMWR Morb Mortal Wkly Rep 2019 Mar 8;68(9):214-219. Epub 2019 Mar 8.

Introduction: Staphylococcus aureus is one of the most common pathogens in health care facilities and in the community, and can cause invasive infections, sepsis, and death. Despite progress in preventing methicillin-resistant S. aureus (MRSA) infections in health care settings, assessment of the problem in both health care and community settings is needed. Read More

MMWR Morb Mortal Wkly Rep 2019 Mar 8;68(9):220-224. Epub 2019 Mar 8.

Introduction: By 2007, all Department of Veterans Affairs medical centers (VAMCs) had initiated a multifaceted methicillin-resistant Staphylococcus aureus (MRSA) prevention program. MRSA and methicillin-susceptible S. aureus (MSSA) infection rates among VAMC inpatients from 2005 to 2017 were assessed. Read More

Plasmid 2019 Mar 4;102:71-82. Epub 2019 Mar 4.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America. Electronic address:

Genetic transfer among bacteria propels rapid resistance to antibiotics and decreased susceptibility to antiseptics. Staphylococcus aureus is a common culprit of hospital and community acquired infections, and S. aureus plasmids have been shown to carry a multitude of antimicrobial resistance genes. Read More