65,612 results match your criteria Staphylococcal Infections


Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis.

Br J Haematol 2019 Feb 15. Epub 2019 Feb 15.

Hannover Medical School, Hannover, Germany.

Eculizumab is the first and only medication approved for paroxysmal nocturnal haemoglobinuria (PNH) and atypical haemolytic uraemic syndrome (aHUS) treatment. However, eculizumab safety based on long-term pharmacovigilance is unknown. This analysis summarises safety data collected from spontaneous and solicited sources from 16 March 2007 through 1 October 2016. Read More

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http://dx.doi.org/10.1111/bjh.15790DOI Listing
February 2019
1 Read

Characterization of the clonal profile of methicillin resistant Staphylococcus aureus isolated from patients with early post-operative orthopedic implant based infections.

Ann Clin Microbiol Antimicrob 2019 Feb 13;18(1). Epub 2019 Feb 13.

Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata, India.

Background: To analyze the molecular epidemiology and to compare between the major methicillin resistant Staphylococcus aureus biotypes for association with patient characteristics who had an implant for closed fracture and developed early post-operative wound infections (POWI) in a tertiary care hospital of India.

Methods: Pulsed-field gel electrophoresis (PFGE), antimicrobial resistance, accessory gene regulator (agr) and staphylococcal cassette chromosome mec (SCCmec) types, Paton-Valentine leukocidin (PVL) gene, toxin gene profiling, biofilm formation and patient demographics were correlated with MLST clonal complexes (CC).

Findings: Overall eight different sequence types (STs) were detected with a predominance of ST239 (66%), ST22 (18%) and some minor types ST772, ST30 (4% each) ST1, ST642, ST6, ST107 (2% each). Read More

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http://dx.doi.org/10.1186/s12941-019-0307-zDOI Listing
February 2019

Same Organism, Different Phenotype - Are Phenotypic Criteria Adequate In Coagulase-Negative Staphylococcal Orthopaedic Implant-Associated Infections?

J Bone Jt Infect 2019 1;4(1):16-19. Epub 2019 Jan 1.

School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

In current diagnostic criteria for implant-associated bone- and joint infections, phenotypically identical low-virulence bacteria in two intraoperative cultures are usually required. Using whole-genome sequencing, we have further characterized three phenotypically different isolated from one prosthetic joint infection, highlighting the challenges in defining microbiological criteria for low-virulence prosthetic joint infections. Read More

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http://dx.doi.org/10.7150/jbji.30256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367199PMC
January 2019

Metabolic Adaptation Supports Persistent Methicillin-Resistant Staphylococcus aureus Pulmonary Infection.

Am J Respir Cell Mol Biol 2019 Feb 11. Epub 2019 Feb 11.

Columbia University, Pediatrics, New York, New York, United States ;

Rationale: Methicillin-resistant Staphylococcus aureus (MRSA) is a versatile human pathogen associated with diverse types of infections, ranging from benign colonization to sepsis. We postulated that MRSA must undergo specific genotypic and phenotypic changes to cause chronic pulmonary disease.

Objectives: We investigated how MRSA adapts to the human airway to establish chronic infection, as occurs during cystic fibrosis (CF). Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2018-0389OC
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http://dx.doi.org/10.1165/rcmb.2018-0389OCDOI Listing
February 2019
3 Reads

Geographic distribution of staphylococcus spp. infections and antimicrobial resistance among dogs from Gauteng Province presented at a veterinary teaching hospital in South Africa.

Spat Spatiotemporal Epidemiol 2019 Feb 22;28:14-23. Epub 2018 Nov 22.

Department of Paraclinical Sciences, Faculty of Veterinary Science, Section Veterinary Public Health, University of Pretoria, Pretoria, Gauteng, South Africa; Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, United States. Electronic address:

The objective of this study was to investigate spatial patterns of staphylococcal infections and resistance patterns of clinical isolates among dogs from Gauteng province in South Africa. Data from records of 1497 dog clinical samples submitted to a veterinary teaching hospital between 2007 and 2012 were used in the study. Spatial empirical Bayesian smoothed risk maps were used to investigate spatial patterns of staphylococcal infections, antimicrobial resistance (AMR), and multidrug resistance (MDR). Read More

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http://dx.doi.org/10.1016/j.sste.2018.11.004DOI Listing
February 2019

An Inhibitory Effect of Dryocrassin ABBA on vWbp That Protects Mice From Pneumonia.

Front Microbiol 2019 23;10. Epub 2019 Jan 23.

College of Animal Sciences, Jilin University, Changchun, China.

Von Willebrand factor-binding protein (vWbp), secreted by (), can activate host prothrombin, convert fibrinogen to fibrin clots, induce blood clotting, and contribute to pathophysiology of -related diseases, including infective endocarditis, staphylococcal sepsis and pneumonia. Therefore, vWbp is an promising drug target in the treatment of related infections. Here, we report that dryocrassin ABBA (ABBA), a natural compound derived from , can significantly inhibit the coagulase activity of vWbp by directly interacting with vWbp without killing the bacteria or inhibiting the expression of the vWbp. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00007
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http://dx.doi.org/10.3389/fmicb.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351477PMC
January 2019
2 Reads

Multimodal imaging guides surgical management in a preclinical spinal implant infection model.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Department of Orthopedic Surgery, David Geffen School of Medicine at UCLA, Santa Monica, California, USA.

Spine implant infections portend disastrous outcomes, as diagnosis is challenging and surgical eradication is at odds with mechanical spinal stability. Current imaging modalities can detect anatomical alterations and anomalies but cannot differentiate between infection and aseptic loosening, diagnose specific pathogens, or delineate the extent of an infection. Herein, a fully human monoclonal antibody 1D9, recognizing the immunodominant staphylococcal antigen A on the surface of Staphylococcus aureus, was assessed as a nuclear and fluorescent imaging probe in a preclinical model of S. Read More

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http://dx.doi.org/10.1172/jci.insight.124813DOI Listing
February 2019

Peritoneal dialysis related infections in a tertiary care hospital in Riyadh, Saudi Arabia.

Saudi Med J 2019 Feb;40(2):147-151

College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To detect the incidence of and risk factors for infections among patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD).

Methods: A retrospective cohort study was conducted at the PD unit of King Fahad Medical City. End-stage renal disease patients above the age of 12 years who were undergoing PD management between January 2006 and March 2016 were included. Read More

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http://dx.doi.org/10.15537/smj.2019.2.23898DOI Listing
February 2019

A FASII inhibitor prevents staphylococcal evasion of daptomycin by inhibiting phospholipid decoy production.

Antimicrob Agents Chemother 2019 Feb 4. Epub 2019 Feb 4.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Rd, London, SW7 2AZ, UK.

Daptomycin is a treatment of last resort for serious infections caused by drug-resistant Gram-positive pathogens such as methicillin-resistant We have shown recently that can evade daptomycin by releasing phospholipid decoys that sequester and inactivate the antibiotic, leading to treatment failure. Since phospholipid release occurs via an active process, we hypothesised that it could be inhibited, thereby increasing daptomycin efficacy. To identify opportunities for therapeutic interventions that block phospholipid release, we first determined how the host environment influenced the release of phospholipids and inactivation of daptomycin by The addition of certain host-associated fatty acids to the growth medium enhanced phospholipid release. Read More

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http://dx.doi.org/10.1128/AAC.02105-18DOI Listing
February 2019

A novel copper (II) PAmPiCaT complex (cPAmPiCaTc) as a biologically potent candidate: A contraption evidence against methicillin-resistant Staphylococcus aureus (MRSA) and a molecular docking proof.

Bioorg Med Chem 2019 Mar 28;27(5):841-850. Epub 2019 Jan 28.

Department of Chemistry, Sri Jayachamarajendra College of Engineering, JSS Science and Technology University, Mysuru 570 006, Karnataka, India. Electronic address:

Increasing in the alarm against the resistant bacteria due to the failure of antibiotics, thereby the need of more efficiency/potent molecule to treat infections. In the present investigation, series of piperazine derivatives 5(a-l) compounds were synthesized and they were characterised by different spectral techniques such as H NMR, C NMR, IR and LCMS. A novel copper complex (cPAmPiCaTc) was developed for the first time by using potent analog 5e and characterized by IR and LCMS. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.01.026DOI Listing
March 2019
1 Read

Analysis of synergy between beta-lactams and anti-methicillin-resistant Staphylococcus aureus agents from the standpoint of strain characteristics and binding action.

J Infect Chemother 2019 Jan 31. Epub 2019 Jan 31.

Department of Microbiology and Infectious Disease, Toho University School of Medicine, Tokyo, Japan. Electronic address:

In light of the increasing number of clinical cases resistant to traditional monotherapies and the lack of novel antimicrobial agents, combination therapy is an appealing solution for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we evaluated the efficacy of anti-MRSA agents, such as vancomycin (VAN), daptomycin (DAP), and linezolid (LZD), in conjunction with 13 beta-lactams and non-beta-lactams. We assessed the in vitro activities of the various combinations against 40 MRSA strains based on the maximum synergistic effect (MSE), an index calculated from the MIC change with a combination agent. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.007DOI Listing
January 2019
1 Read

A ten year study of prevalence, antimicrobial susceptibility pattern, and genotypic characterization of Methicillin resistant Staphylococcus aureus causing ocular infections in a tertiary eye care hospital in South India.

Infect Genet Evol 2019 Jan 30;69:203-210. Epub 2019 Jan 30.

Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, India. Electronic address:

Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of vision threatening ocular infections. This study aimed to determine the prevalence and antimicrobial susceptibility pattern of MRSA and their genotypic characterization in ocular infections. The study period was from January 2007 to December 2017 in Aravind Eye Hospital, Madurai. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.01.031DOI Listing
January 2019

Reliability and accuracy of smartphones for paediatric infectious disease consultations for children with rash in the paediatric emergency department.

BMC Pediatr 2019 Jan 31;19(1):40. Epub 2019 Jan 31.

Department of Pediatric Emergency Department, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Objective: Smartphones and associated messaging applications have become the most common means of communication among health care workers and the general population. The aim of this study was to evaluate the reliability and accuracy of smartphones for the diagnosis of rash in children admitted to emergency departments during the night shift.

Methods: The images of the children who were admitted to the paediatric emergency department with rash were included in this study, and at least two images taken with smartphones by residents or paediatric infectious disease fellows were re-directed to the chief consultant of the Paediatric-Infectious Department via smartphone. Read More

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http://dx.doi.org/10.1186/s12887-019-1416-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354364PMC
January 2019
1 Read

Ceftaroline Plus Daptomycin for Refractory Methicillin- Resistant Staphylococcus aureus Bacteremia in a Child.

J Pediatr Pharmacol Ther 2018 Nov-Dec;23(6):490-493

Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can be difficult to treat, with growing adult literature supporting the combination of ceftaroline and daptomycin for these patients. Here, we report a pediatric patient with persistent MRSA bacteremia with associated cellulitis, fasciitis, myositis, and a deep venous thrombosis causing septic pulmonary emboli. After being unable to clear the bacteremia on vancomycin and then daptomycin monotherapy, the bacteremia cleared quickly with rapid clinical improvement after the addition of ceftaroline to daptomycin. Read More

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http://dx.doi.org/10.5863/1551-6776-23.6.490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336175PMC
January 2019
1 Read

Efficacy of silver nanoparticles against multidrug resistant clinical Staphylococcus aureus isolates from Nigeria.

J Immunoassay Immunochem 2019 Jan 29:1-23. Epub 2019 Jan 29.

d Department of Microbiology , Lagos State University , Lagos , Nigeria.

Multidrug resistant (MDR) S. aureus infections continue to account for excess mortality in hospital and community settings and constitute a rising global health problem. However, data on the efficacy and mechanism of actions of alternative solutions like silver nanoparticles in developing countries are lacking. Read More

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http://dx.doi.org/10.1080/15321819.2018.1555765DOI Listing
January 2019
1 Read

Staphylococcus pseudintermedius septicemia in puppies after elective cesarean section: confirmed transmission via dam's milk.

BMC Vet Res 2019 Jan 28;15(1):41. Epub 2019 Jan 28.

Clinic for Reproduction and Large Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000, Ljubljana, Slovenia.

Background: In humans, transmission of bacteria causing fatal sepsis in the neonates through mother's milk has been reported. In dogs, it is believed that bacteria from canine milk are not the primary cause of neonatal infections. Staphylococcus pseudintermedius is colonizing the skin and mucocutaneous junctions in adult dogs and can act as an opportunistic pathogen. Read More

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http://dx.doi.org/10.1186/s12917-019-1795-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348621PMC
January 2019
2 Reads

Metagenomic quorum quenching enzymes affect biofilm formation of Candida albicans and Staphylococcus epidermidis.

PLoS One 2019 28;14(1):e0211366. Epub 2019 Jan 28.

Kiel University, Institute for General Microbiology, Kiel, Germany.

Biofilm formation in the clinical environment is of increasing concern since a significant part of human infections is associated, and caused by biofilm establishment of (opportunistic) pathogens, for instance Candida albicans and Staphylococcus epidermidis. The rapidly increasing number of antibiotic-resistant biofilms urgently requires the development of novel and effective strategies to prevent biofilm formation ideally targeting a wide range of infectious microorganisms. Both, synthesis of extracellular polymeric substances and quorum sensing are crucial for biofilm formation, and thus potential attractive targets to combat undesirable biofilms. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211366PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349329PMC
January 2019
1 Read

Distribution of virulence genes in bacteremic methicillin-resistant Staphylococcus aureus isolates from various sources.

J Microbiol Immunol Infect 2019 Jan 10. Epub 2019 Jan 10.

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.

Background/purpose: Methicillin-resistant Staphylococcus aureus (MRSA) can encode proteins which directly bind bacteria to many tissues and medical devices or catheters to trigger pathogenesis. However, the relationship between genetic backgrounds and virulent factors in MRSA isolates remained incompletely understood yet.

Methods: MRSA isolates were collected from blood cultures of patients with infective endocarditis, bone/joint infection, skin/soft tissue infection, or catheter-related bacteremia in hemodialysis at a tertiary medical center between 2005 and 2011. Read More

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http://dx.doi.org/10.1016/j.jmii.2019.01.001DOI Listing
January 2019
1 Read

Eradicating MRSA carriage: the impact of throat carriage and Panton-Valentine leukocidin genes on success rates.

Eur J Clin Microbiol Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Department of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.

In Denmark, eradication treatment is recommended for methicillin-resistant Staphylococcus aureus (MRSA) carriers. Here, we analyze factors associated with eradication outcome. MRSA carriers referred to the MRSA Knowledge Center at Hvidovre Hospital in 2013 were included. Read More

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http://dx.doi.org/10.1007/s10096-019-03474-6DOI Listing
January 2019
1 Read

The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.

J Med Microbiol 2019 Jan 24. Epub 2019 Jan 24.

2​Veterans Affairs Medical Center, Boise, ID, USA.

Purpose: Extracellular protein toxins contribute to the pathogenesis of Staphylococcus aureus infections. The present study compared the effects of iclaprim and trimethoprim - two folic acid synthesis inhibitors - with nafcillin and vancomycin on production of Panton-Valentine leukocidin (PVL), alpha haemolysin (AH) and toxic-shock syndrome toxin I (TSST-1) in methicillin-resistant and vancomycin-intermediate S. aureus (MRSA and VISA, respectively). Read More

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http://dx.doi.org/10.1099/jmm.0.000929DOI Listing
January 2019

Nasopharingeal bacterial and fungal colonization in HIV-positive versus HIV-negative adults.

New Microbiol 2019 Jan 23;42(1). Epub 2019 Jan 23.

Infectious Diseases Unit, Azienda Ospedaliera Universitaria Senese, Siena Italy.

To compare mucosal flora in HIV-positive and HIV-negative subjects, to assess chemosusceptibility patterns of carriage isolates and to evaluate possible predisposing factors within the two groups. We analyzed microbes isolated from nasopharyngeal swabs in virologically suppressed and immunologically stable HIV-positive adult outpatients (n=105) at baseline and after 12 months and in an age-matched cohort of HIV-negative outpatients (n=100) at baseline. Bacteria and Candida spp strains were isolated and identified through standard biochemical assays and chemosusceptibility tests were performed. Read More

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January 2019

Redundant and Distinct Roles of Secreted Protein Eap and Cell Wall-Anchored Protein SasG in Biofilm Formation and Pathogenicity of .

Infect Immun 2019 Jan 22. Epub 2019 Jan 22.

Department of Bacteriology, The Jikei University School of Medicine, Tokyo, Japan.

Chronic and fatal infections caused by are sometimes associated with biofilm formation. Secreted proteins and cell wall-anchored proteins (CWAPs) are important for the development of polysaccharide-independent biofilms, but functional relationships between these proteins are unclear. In the current study, we report the roles of the extracellular adherence protein Eap and surface CWAP SasG in MR23, a clinical methicillin-resistant isolate that forms a robust protein-dependent biofilm and accumulates a large amount of Eap in the extracellular matrix. Read More

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http://dx.doi.org/10.1128/IAI.00894-18DOI Listing
January 2019

The Anti-Staphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood to Potentiate MRSA Bacteriolysis.

Antimicrob Agents Chemother 2019 Jan 22. Epub 2019 Jan 22.

ContraFect Corporation, Yonkers, NY

Bacteriophage-derived lysins are cell wall hydrolytic enzymes which represent a potential new class of antibacterial therapeutics in development to address burgeoning antimicrobial resistance. CF-301, the lead compound in this class, is in clinical development as an adjunctive treatment to potentially improve clinical cure rates of bacteremia and infective endocarditis (IE) when used in addition to antibiotics. In order to profile CF-301's activity in a clinically relevant milieu, we assessed its activity in human blood vs. Read More

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http://dx.doi.org/10.1128/AAC.02291-18DOI Listing
January 2019
1 Read

Neonatal Skin Emergencies.

Pediatr Ann 2019 Jan;48(1):e36-e42

Although the majority of neonatal skin rashes can be safely monitored without intervention, there are a significant few that are dermatologic emergencies. When called to assess a neonate, it is important to distinguish what requires immediate diagnosis and treatment from those that represent benign etiologies. The skin may be the first clue to certain infections such as herpes simplex virus, syphilis, varicella, cytomegalovirus, fungal infections, and staphylococcal scalded skin syndrome, all of which require immediate testing and some of which may lead to severe sequelae. Read More

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http://dx.doi.org/10.3928/19382359-20181210-03DOI Listing
January 2019
4 Reads

Improved Performance of a Rapid Immunochromatographic Assay for the Detection of PBP2a in non- Staphylococcal Species.

J Clin Microbiol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

Non- staphylococcal species (non-SASS) are important pathogens in both animal and human populations. The development of β-lactam resistance in non-SASS through acquisition and expression of penicillin-binding protein 2a (PBP2a) represents a significant clinical and public health threat. Here, we evaluated the diagnostic performance of two versions of a PBP2a immunochromatographic assay with non-SASS. Read More

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http://dx.doi.org/10.1128/JCM.01417-18DOI Listing
January 2019

Identification of biologic agents to neutralize the bicomponent leukocidins of .

Sci Transl Med 2019 Jan;11(475)

Department of Microbiology, New York University School of Medicine, Alexandria Center for Life Science, 430 East 29th Street, New York, NY 10016, USA.

A key aspect underlying the severity of infections caused by is the abundance of virulence factors that the pathogen uses to thwart critical components of the human immune response. One such mechanism involves the destruction of host immune cells by cytolytic toxins secreted by , including five bicomponent leukocidins: PVL, HlgAB, HlgCB, LukED, and LukAB. Purified leukocidins can lyse immune cells ex vivo, and systemic injections of purified LukED or HlgAB can acutely kill mice. Read More

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aat0882DOI Listing
January 2019
7 Reads
15.843 Impact Factor

Copper Bead Therapy in Severe Bone Infection: A Rabbit Tibial Model.

Vet Comp Orthop Traumatol 2019 Jan 15;32(1):41-50. Epub 2019 Jan 15.

Unit of Animal Experimentation "Cantacuzino" National Institute for Medico-Military Research and Development, Bucharest, Romania.

Objective:  We investigated the benefits of a local preventive therapy based on copper beads against severe bone infection using a rabbit open tibial fracture model.

Materials And Methods:  Cotton mesh balls soaked in a very high concentration of ATCC 6538 culture were inoculated in drilled holes of the tibiae of treated and control groups. The treated group was also implanted with small copper beads simultaneously, as prevention therapy. Read More

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http://dx.doi.org/10.1055/s-0038-1676292DOI Listing
January 2019
2 Reads
0.894 Impact Factor

Preventive effect of the phage VB-SavM-JYL01 on rabbit necrotizing pneumonia caused by Staphylococcus aureus.

Vet Microbiol 2019 Feb 18;229:72-80. Epub 2018 Dec 18.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, PR China. Electronic address:

Staphylococcus aureus is one of the most important pathogens causing rabbit necrotizing pneumonia and brings huge economic losses to rabbit production. This study investigated the preventive effect of a phage on rabbit necrotizing pneumonia caused by S. aureus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781135183132
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http://dx.doi.org/10.1016/j.vetmic.2018.12.021DOI Listing
February 2019
12 Reads
2.511 Impact Factor

Use of a modified bacterial ghost lysis system for the construction of an inactivated avian pathogenic Escherichia coli vaccine candidate.

Vet Microbiol 2019 Feb 17;229:48-58. Epub 2018 Dec 17.

Shanghai Veterinary Research Institute, the Chinese Academy of Agricultural Sciences (CAAS), 518 Ziyue Road, Shanghai, 200241, PR China. Electronic address:

Vaccination is an effective strategy to prevent avian colibacillosis. Bacterial ghosts (BGs) are prepared by the controlled expression of the phiX174 gene E, which mediates the lysis of Gram-negative bacteria. Staphylococcal nuclease A may be used to produce BGs for further inactivation of host bacteria and elimination of residual genetic material. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.12.020DOI Listing
February 2019
2 Reads

[The role of emollients in atopic dermatitis in children].

Authors:
Ewa Kamińska

Dev Period Med 2018 ;22(4):396-403

Zakład Farmakologii, Instytut Matki i Dziecka, Warszawa, Polska.

Atopic dermatitis is a chronic inflammatory disease characterized by recurrent flares, intense itching, erythema, dry skin resulting from skin barrier defects, and staphylococcal infections. Multiple factors may affect the skin`s normal barrier function, including filaggrin gene mutations, immune dysregulation, altered skin microbiome, altered lipids in stratum corneum, or deficiency of antimicrobial peptides AMPs. The disease mainly affects children, causing a considerable impact on the quality of their life; its first manifestations occur with up to 90% of cases before the age of 5. Read More

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January 2018
5 Reads

Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant .

Proc Natl Acad Sci U S A 2019 Jan 11;116(5):1745-1754. Epub 2019 Jan 11.

Division of Infectious Diseases and Immunology, Department of Medicine, New York University School of Medicine, New York, NY 10016;

The past two decades have witnessed an alarming expansion of staphylococcal disease caused by community-acquired methicillin-resistant (CA-MRSA). The factors underlying the epidemic expansion of CA-MRSA lineages such as USA300, the predominant CA-MRSA clone in the United States, are largely unknown. Previously described virulence and antimicrobial resistance genes that promote the dissemination of CA-MRSA are carried by mobile genetic elements, including phages and plasmids. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814265116
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http://dx.doi.org/10.1073/pnas.1814265116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358666PMC
January 2019
8 Reads

Grisel syndrome presenting as hemiplegia in a patient with multifocal sepsis.

Malawi Med J 2018 06;30(2):127-131

Consultant Trauma and Orthopaedic Surgeon; Dean of Faculty of Medicine, College of Medicine, University of Malawi.

Introduction: Grisel syndrome is a non-traumatic rotary subluxation of C1 on C2 (atlantoaxial subluxation). It is a rare condition predominantly described in paediatric population with previous history of upper respiratory infections orotolaryngeal procedures. The diagnosis is established by the association of clinical and radiologic findings4,6. Read More

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http://dx.doi.org/10.4314/mmj.v30i2.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307069PMC
June 2018
2 Reads

Effect of mazEF, higBA and relBE toxin-antitoxin systems on antibiotic resistance in Pseudomonas aeruginosa and Staphylococcus isolates.

Malawi Med J 2018 06;30(2):67-72

Recep Tayyip Erdoğan University Faculty of Medicine, Department of Medical Microbiology, Turkey.

Background: A toxin-antitoxin (TA) system is a set of two or more closely linked genes that are encoded as a poison and a corresponding antidote on a protein. In typical bacterial physiology, an antitoxin binds to a toxin and neutralizes it, which prevents the bacterium from killing itself. We aimed to determine whether and isolates have TA genes and to investigate whether there is a relationship between the expression levels of TA genes and resistance to antibiotics. Read More

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http://dx.doi.org/10.4314/mmj.v30i2.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307074PMC

Regional outbreak of community-associated methicillin-resistant Staphylococcus aureus ST834 in Japanese children.

BMC Infect Dis 2019 Jan 9;19(1):35. Epub 2019 Jan 9.

Department of Infection Control Science, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection has recently become a challenging problem worldwide and in Japan. We experienced 10 pediatric patients infected with CA-MRSA and hospitalized from 2011 to 2014 in a tertiary care hospital in Saitama, Japan, and assessed the characteristic of the strains using a whole genome sequencing (WGS)-based approach.

Methods: CA-MRSA strains isolated from infected patients who required hospitalization for treatment were evaluated in this study. Read More

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http://dx.doi.org/10.1186/s12879-018-3646-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327381PMC
January 2019
1 Read

Staphylococcus aureus: setting its sights on the human innate immune system.

Microbiology 2019 Jan 9. Epub 2019 Jan 9.

1​The Bateson Centre and Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Staphylococcus aureus has colonized humans for at least 10 000 years, and today inhabits roughly a third of the population. In addition, S. aureus is a major pathogen that is responsible for a significant disease burden, ranging in severity from mild skin and soft-tissue infections to life-threatening endocarditis and necrotizing pneumonia, with treatment often hampered by resistance to commonly available antibiotics. Read More

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http://www.microbiologyresearch.org/content/journal/micro/10
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http://dx.doi.org/10.1099/mic.0.000759DOI Listing
January 2019
5 Reads

Evolution of daptomycin resistance in coagulase negative staphylococci involves mutations of the essential two component regulator WalKR.

Antimicrob Agents Chemother 2019 Jan 7. Epub 2019 Jan 7.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia

Coagulase-negative staphylococci (CoNS) represent one of the major causes of healthcare- and medical device-associated infections. Emerging antimicrobial resistance has complicated treatment of systemic infections caused by CoNS. Here, we describe the prevalence of antimicrobial resistance in clinical CoNS strains from a tertiary care hospital over a four-year period, and observed a significant increase in resistance to daptomycin. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01926-18
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http://dx.doi.org/10.1128/AAC.01926-18DOI Listing
January 2019
7 Reads

Immunization of young heifers with staphylococcal immune evasion proteins before natural exposure to Staphylococcus aureus induces a humoral immune response in serum and milk.

BMC Vet Res 2019 Jan 7;15(1):15. Epub 2019 Jan 7.

Department of Large Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Staphylococcus aureus, a leading cause of mastitis in dairy cattle, causes severe mastitis and/or chronic persistent infections with detrimental effects on the cows' wellbeing, lifespan and milk production. Despite years of research there is no effective vaccine against S. aureus mastitis. Read More

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http://dx.doi.org/10.1186/s12917-018-1765-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323680PMC
January 2019
2 Reads

Case report: Staphylococcus aureus endocarditis in 2 premature newborns.

Medicine (Baltimore) 2019 Jan;98(1):e13549

Neonatal Intensive Care Unit, Department of Pediatric Medicine, CHU de Saint-Etienne.

Rationale: Neonatal infectious endocarditis (IE) in a healthy heart is rare. The infectious agents most frequently found in newborns are Staphylococcus aureus and fungi. Infection at the site of central intravenous catheter is generally thought to be the cause of this pathology. Read More

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http://dx.doi.org/10.1097/MD.0000000000013549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344129PMC
January 2019
5 Reads

Transcriptional regulation of by both IcaR and TcaR in .

J Bacteriol 2019 Jan 2. Epub 2019 Jan 2.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE. USA.

is a primary cause of biofilm-mediated infections in humans due to adherence to foreign bodies. A major staphylococcal biofilm accumulation molecule is polysaccharide intracellular adhesin (PIA), which is synthesized by enzymes encoded by the operon. Expression of PIA is highly variable amongst clinical isolates suggesting that PIA expression levels are selected in certain niches of the host. Read More

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http://dx.doi.org/10.1128/JB.00524-18DOI Listing
January 2019

AAOS Systematic Literature Review: Summary on the Management of Surgical Site Infections.

J Am Acad Orthop Surg 2018 Dec 28. Epub 2018 Dec 28.

From Orthopaedic Surgery, University of Arizona, College of Medicine-Phoenix, Phoenix, AZ (Dr. McLaren), and Resurgens Orthopaedics, Atlanta, GA (Dr. Lundy).

The purpose of this systematic review is to improve outcomes for the care of surgical site infections by presenting the current best evidence on important diagnostic and care issues. The findings led to ten recommendations and five consensus statements that address diagnosis and treatment of orthopaedic surgical site infections. There is strong evidence to supports anemia, obesity, HIV/AIDS, depression, dementia, immunosuppressive medications, duration of hospital stay, history of alcohol abuse, and history of congestive heart failure as factors that increased the risk of infection, some of which are modifiable before surgical intervention. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00653DOI Listing
December 2018
1 Read

Partial prediction of the duration and the clinical status of Staphylococcus aureus bovine intramammary infections based on the phenotypic and genotypic analysis of isolates.

Vet Microbiol 2019 Jan 24;228:188-195. Epub 2018 Nov 24.

Département de Pathologie et Microbiologie and Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC, J2S 2M2, Canada. Electronic address:

Staphylococcus aureus is a bacterial pathogen causing bovine intramammary infections (IMIs) often leading to chronic clinical or subclinical mastitis. Predicting the outcome of S. aureus IMIs (duration and clinical vs subclinical) based on the characterization of isolates would help to make better case management decisions. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.11.024DOI Listing
January 2019
1 Read

Use of geographical information system and ecological niche modelling for predicting potential space distribution of subclinical mastitis in ewes.

Vet Microbiol 2019 Jan 20;228:119-128. Epub 2018 Nov 20.

Veterinary Faculty, University of Thessaly, 43100, Karditsa, Greece. Electronic address:

Objective was to recognise areas potentially of high risk for increased frequency of subclinical mastitis in ewes. Milk samples were collected, for bacteriological and cytological examination, from 2198 clinically healthy ewes in 111 farms in all administrative regions of Greece. Data on farms were located in the field using hand-held Global Positioning System Garmin units. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.11.021DOI Listing
January 2019

Intravenously administered cloxacillin-induced neutropenia with eosinophilia in a patient with infective endocarditis: a case report.

J Med Case Rep 2018 Dec 29;12(1):384. Epub 2018 Dec 29.

Teaching Hospital Kurunegala, Kurunegala, Sri Lanka.

Background: Bacteremia following Staphylococcus aureus is a serious clinical condition which is often associated with distant metastatic infections. One of the most dreaded complications of Staphylococcus aureus bacteremia is infective endocarditis. Cloxacillin is a common antibiotic prescribed for suspected staphylococcal infections and confirmed methicillin-sensitive Staphylococcus aureus infections. Read More

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http://dx.doi.org/10.1186/s13256-018-1933-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310943PMC
December 2018
1 Read

In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis.

Ann Clin Microbiol Antimicrob 2018 Dec 28;17(1):46. Epub 2018 Dec 28.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia.

Background: Osteomyelitis is an acute or chronic inflammatory process of the bone following infection with pyogenic organisms like Staphylococcus aureus. Tobramycin (TOB) is a promising aminoglycoside antibiotic used to treat various bacterial infections, including S. aureus. Read More

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https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12941-018-0296-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309062PMC
December 2018
8 Reads
1.514 Impact Factor

Community-acquired methicillin-resistant from ST1 lineage harboring a new SCC IV subtype (SCC IVm) containing the gene.

Infect Drug Resist 2018 14;11:2583-2592. Epub 2018 Dec 14.

Laboratory of Molecular Biology of Bateria, Department of Medical Microbiology, Paulo de Goes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil,

A pivotal event in the evolutionary path of methicillin-resistant (MRSA) is the acquisition of the staphylococcal cassette chromosome (SCC) element carrying the gene, the determinant of methicillin resistance. Community-acquired (CA) MRSA is commonly associated with skin/soft tissue infections, and doxycycline is one of the drug choices for this purpose. Doxycycline resistance is associated with the acquisition of the gene carried by the plasmid pT181, which may also be integrated into SCC III and V. Read More

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http://dx.doi.org/10.2147/IDR.S175079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299468PMC
December 2018

Chitosan disrupts biofilm formation and promotes biofilm eradication in Staphylococcus species isolated from bovine mastitis.

Int J Biol Macromol 2019 Apr 23;126:60-67. Epub 2018 Dec 23.

Instituto Académico Pedagógico de Ciencias Básicas y Aplicadas (IAPCByA), Universidad Nacional Villa María (UNVM), Villa María, Argentina; Centro de Investigaciones y Transferencia de Villa María (CIT-VM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad Nacional Villa María (UNVM), Villa María, Argentina. Electronic address:

Staphylococci are the main pathogens associated with hard-to-control intramammary infections in dairy cattle, and bacterial biofilms are suspected to be responsible for the antimicrobial resistance and persistence of this disease. Biofilms have the ability to resist to higher levels of antibiotics and reduce their efficacy. It is thus necessary to develop strategies targeted to bacterial biofilm infections. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.12.159DOI Listing
April 2019
4 Reads

Aggregating resistant Staphylococcus aureus induces hypocoagulability, hyperfibrinolysis, phagocytosis, and neutrophil, monocyte, and lymphocyte binding in canine whole blood.

Vet Clin Pathol 2018 Dec;47(4):560-574

Department of Veterinary Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark.

Background: Staphylococcus aureus is an opportunistic pathogen with the ability to form mobile planktonic aggregates during growth, in vitro. The in vivo pathophysiologic effects of S aureus aggregates on host responses are unknown. Knowledge of these could aid in combating infections. Read More

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http://dx.doi.org/10.1111/vcp.12679DOI Listing
December 2018
2 Reads

Molecular Characteristics of Methicillin-Resistant Staphylococci Clinical Isolates from a Tertiary Hospital in Northern Thailand.

Can J Infect Dis Med Microbiol 2018 19;2018:8457012. Epub 2018 Nov 19.

Department of Microbiology and Parasitology, Faculty of Medical Sciences, Naresuan University, Phitsanulok, Thailand.

Methicillin-resistant staphylococci are now recognized as a major cause of infectious diseases, particularly in hospitals. Molecular epidemiology is important for prevention and control of infection, but little information is available regarding staphylococcal infections in Northern Thailand. In the present study, we examined antimicrobial susceptibility patterns, detection of antimicrobial resistance genes, and SCC types of methicillin-resistant (MRSA) and methicillin-resistant coagulase-negative staphylococci (MR-CoNS) isolated from patients in a hospital in Northern Thailand. Read More

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http://dx.doi.org/10.1155/2018/8457012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276523PMC
November 2018