Search Our Scientific Publications & Authors

J Appl Microbiol 2018 Dec 16. Epub 2018 Dec 16.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.

Aims: Hydrogen peroxide (H O ) disinfection applications are limited by its rapid inactivation. The aims of this study were to 1) microencapsulate H O in silica hydrogels to obtain controlled release up to 72 hours, 2) test hydrogel antimicrobial activity against four common pathogens, and 3) assess H O release kinetics and antimicrobial activity in 35 - 65% relative humidity and 37°C to approximate bandaged wound conditions.

Methods And Results: Hydrogels were characterized using scanning electron microscopy, nitrogen sorption porosimetry, Brunauer Emmet Teller analysis, and the Barret - Joyner - Halenda method. Read More

Ann Ig 2019 Jan-Feb;31(1):52-61

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: As a great opportunistic pathogen, Staphylococcus epidermidis participates in a wide spectrum of infections by residing in the medical devices. Regardless of the clinical importance of S. epidermidis, there are a few data about typing of clinical and non-clinical isolates at the subspecies level in Iran. Read More

J Neurosurg 2018 Dec 14:1-8. Epub 2018 Dec 14.

OBJECTIVEPostoperative surgical site infections (SSIs) in neurosurgical patients carry a significant risk of increased morbidity and mortality. With SSIs accounting for approximately 20% of nosocomial infections and costing approximately $1.6 billion USD annually, there is a need for additional prophylaxis to improve current standards of care. Read More

Microb Pathog 2018 Dec 13. Epub 2018 Dec 13.

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Bacterial superantigens are potent T cell activators that can have acute or chronic effects on the central nervous system.

Objectives: In this study, the role of enterotoxins, exfoliative toxins and toxic shock syndrome toxin of Staphylococcus aureus was investigated in MS patients and healthy nasal carriers.

Methods: Three-hundred fifty nasal swabs were collected from healthy nasal carriers (n = 210) and MS (n = 140) patients. Read More

Carbohydr Polym 2019 Feb 13;206:548-556. Epub 2018 Nov 13.

Biotechnology Program, Department of Environmental Sciences, COMSATS University Islamabad, Abbottabad Campus 22060, Pakistan. Electronic address:

Bacterial cellulose (BC) is a promising biopolymer with wound healing and tissue regenerative properties but lack of antimicrobial property limits its biomedical applications. Therefore, current study was proposed to combine wound healing property of BC with antimicrobial activity of montmorillonite (MMT) and modified montmorillonites (Cu-MMT, Na-MMT and Ca-MMT) to design novel artificial substitute for burns. Designed nanocomposites were characterized through Fe-SEM, FTIR and XRD. Read More

Carbohydr Polym 2019 Feb 12;206:362-370. Epub 2018 Nov 12.

Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, 88701-000, Tubarão, SC, Brazil.

A smart wound dressing based on carrageenan (κC), locust bean gum (LBG), and cranberry extract (CB) for monitoring bacterial wound infections was developed and characterized using UV-vis spectroscopy, FT-IR, and SEM. The mechanical, swelling, cytotoxic and pH sensor properties were also investigated. UV-vis spectra demonstrated that the obtained κC:LBG:CB hydrogel film exhibited a visible change of colors as it was immersed in PBS solution pH 5. Read More

BMC Pediatr 2018 Dec 15;18(1):388. Epub 2018 Dec 15.

Children's Hospital of Michigan, Detroit, MI, USA.

Background: There have been few studies focused on the prevalence, bacterial etiology, antibiotic resistance, and genetic background of Staphylococcus aureus (S. aureus) in children with acute otitis media (AOM) in China.

Methods: A retrospective study was conducted in Liuzhou Maternity and Child Healthcare Hospital. Read More

J Crit Care 2018 Dec 12;50:169-176. Epub 2018 Dec 12.

Dipartimento di Scienza dell'Emergenza, Anestesiologiche e della Rianimazione - UOC di Anestesia, Rianimazione, Terapia Intensiva e Tossicologia Clinica - Istituto di Anestesia e Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma - Università Cattolica del Sacro Cuore, Italy. Electronic address:

Purpose: To assess risk factors for 28-day mortality and cost implications in intensive care unit (ICU) patients with complicated intra-abdominal infections (cIAIs).

Methods: Single-center retrospective cohort study of prospectively collected data analysing ICU patients with a microbiologically confirmed complicated intra-abdominal infections.

Results: 137 complicated intra-abdominal infections were included and stratified according to the adequacy of antimicrobial therapy (initial inadequate antimicrobial therapy [IIAT], n = 44; initial adequate antimicrobial therapy [IAAT], n = 93). Read More

Int J Food Microbiol 2018 Nov 22;292:8-12. Epub 2018 Nov 22.

German Federal Institute for Risk Assessment (BfR), Department Biological Safety, Berlin, Germany. Electronic address:

The aim of this study was to detect, to quantify and to characterize MRSA in broiler meat samples with skin. Furthermore, we compared an isolation method using a second selective enrichment step (method A) with a simpler method omitting this step (method B). For quantification we used a direct plating method on selective agar plates and a "Most probable number" (MPN) technique for estimation of low numbers of MRSA. Read More

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

First Department of Medicine, "Laikon" General Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece. Electronic address:

Objectives: We aimed to assess the MRSA Bloodstream Infection (BSI) rates and the population structure of the MRSA isolates recovered between 2000 and 2015 in a tertiary care hospital in Athens, Greece.

Methods: Non-repetitive MRSA blood isolates recovered during the study period were examined. Antimicrobial susceptibility testing was performed by Kirby-Bauer and the gradient strip methods Carriage of the PVL and mecA genes were examined by PCR. Read More

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Clinical Pathology, Helwan Faculty of Medicine, Egypt.

Objective: The goals of the present study were to i.determine the prevalence of qac and smr genes in clinical isolates of S.aureus from hospital acquired infections ii. Read More

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Bacterial Epidemiology and Antimicrobial Resistance Research Unit, USDA-ARS, Athens, Georgia, USA. Electronic address:

Objectives: Staphylococcus aureus is one of the leading causes of nosocomial and community-acquired infections. Treatment of those infections with macrolide-lincosamide-streptogramin (MLS) antibiotics has led to resistance to those antibiotics through various mechanisms. S. Read More

Arch Biochem Biophys 2018 Dec 12. Epub 2018 Dec 12.

Laboratório de Biotecnologia Marinha - BioMar-Lab, Departamento de Engenharia de Pesca, Universidade Federal do Ceará, Campus do Pici s/n, bloco 871, 60440-970, Fortaleza, Ceará, Brazil. Electronic address:

A new mucin-binding lectin (AFL) was isolated from the marine sponge Aplysina fulva. AFL was purified by affinity chromatography on Sepharose™ matrix. Its hemagglutinating activity was independent of divalent ions, and it was weakly inhibited by simple sugars. Read More

J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Dalhousie University and the IWK Health Centre, Halifax, NS, Canada.

Objective: To identify the temporal trends, risk factors and outcomes of cystic white matter injury (WMI) detected by ultrasound in a population-based cohort of very preterm infants (VPI) with a minimal risk of selection bias.

Study Design: All live-born VPIs between 22 and < 31 weeks gestational age born in Nova Scotia, Canada from 1993 to 2013.

Results: Cystic WMI was identified in 87 (7%) out of 1184 eligible infants. Read More

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Dept of Internal Medicine & Radboud Center for Infectious Diseases, Radboud university medical ctr.

Current guidelines recommend intravenous antibiotic therapy for at least 4 weeks in patients with high-risk Staphylococcus aureus bacteremia (SAB), because of the risk for metastatic infection. We evaluated the safety of shorter duration of treatment in patients with high-risk SAB without signs of metastatic infection at presentation, using standard F-FDG PET/CT and echocardiography. Retrospective analyses were performed of patients with SAB admitted between 2013 and 2017 in two medical centers. Read More

Bioorg Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Bioorganic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road Jammu, 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IIIM Campus, Jammu 180001, India. Electronic address:

Inhibitors for NorA efflux pump of Staphylococcus aureus have attracted the attention of many researchers towards the discovery and development of novel efflux pump inhibitors (EPIs). In an attempt to find specific potent inhibitors of NorA efflux pump of S. aureus, a total of 15 amino acid conjugates of 3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid (4-18) were synthesized using a simple convenient synthetic approach and bioevaluated against NorA efflux pump. Read More

Molecules 2018 Dec 13;23(12). Epub 2018 Dec 13.

Servico de Biotecnologia Vegetal, Fundacao Ezequiel Dias (FUNED), Belo Horizonte 30510-010, MG, Brazil.

This paper reports the in silico prediction of biological activities of lignans from and combined with an in vitro bioassays. The extracts from the leaves, roots and rhizomes of both species were evaluated for their antibacterial, anticholinesterasic, antioxidant and cytotoxic activities. A group of 27 lignans was selected for biological activities prediction using the Active-IT system with 1987 ligand-based bioactivity models. Read More

Mar Drugs 2018 Dec 13;16(12). Epub 2018 Dec 13.

GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany.

The metabolism of seaweeds depends on environmental parameters, the availability of nutrients, and biotic/abiotic stresses; therefore, their chemical composition fluctuates throughout the year. This study investigated seasonal variations in the metabolome of the Baltic Sea brown alga and its potential relation to the bioactivity profile. By using a definitive screening design (DSD) combined with pressurised liquid extraction (PLE), an optimised protocol was developed to extract algal biomass monthly for a full calendar year. Read More

Biomed Pharmacother 2019 Jan 26;109:1940-1950. Epub 2018 Nov 26.

College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang 330045, China.

Azalomycin F was a polyhydroxy macrolide produced by streptomycete strains. Our preliminary researches indicated that it could kill methicillin-resistant Staphylococcus aureus (MRSA) likely by increasing the permeability of cell membrane, and that cell-membrane phospholipids were likely important targets. To confirm this, membrane permeability assay was performed and visualized by fluorescence staining, and then the detailed interactions between azalomycin F and model membranes prepared with 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DPPG) were determined using attenuated total reflectance fourier transform infrared spectroscopy and P nuclear magnetic resonance techniques. Read More

Biomed Pharmacother 2019 Jan 26;109:1809-1818. Epub 2018 Nov 26.

Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mupirocin (MUP), bactroban, or pseudomonic acid is a natural crotonic acid derivative drug extracted from Pseudomonas fluorescens which is produced by modular polyketide synthases. This antibiotic has a unique chemical structure and mechanism of action. It is a mixture of A-D pseudomonic acids and inhibits protein synthesis through binding to bacterial isoleucyl-tRNA synthetase. Read More

Colloids Surf B Biointerfaces 2019 Jan 28;173:876-883. Epub 2018 Oct 28.

Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, UAM. Av. Reyes Católicos 2, 28040 Madrid, Spain. Electronic address:

Objective: Implant-related infection is a devastating complication in orthopedic surgery. Aiming to minimize this problem, many material modifications have been developed. Here we report a study of a surface modification of Ti-6 Al-4 V alloy using a methodology that enables the study of interactions between bacteria and the material in the presence of eukaryotic cells. Read More

Colloids Surf B Biointerfaces 2019 Jan 23;173:833-841. Epub 2018 Oct 23.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China. Electronic address:

Titanium and its alloys are widely used in many clinical applications, but implant-associated infection may lead to implant failure. Because of the increasing concern about antibiotic resistant pathogen, photothermal therapy (PTT) as a new treatment strategy has received considerable attention. In this work, gold nanorods (GNRs) photoexcited by the near-infrared (NIR) light were immobilized on Ti surface by electrostatic surface self-assembly technique. Read More

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, New York University School of Medicine, New York, New York.

Objective:  We sought to examine pathogen distribution and clinical presentation of late-onset sepsis (LOS) at an urban tertiary care center.

Study Design:  We performed a retrospective review of all culture-confirmed cases of LOS presenting to our institution from 2013 to 2017. Medical records were evaluated for demographic information, sepsis risk factors, encounter location, and clinical outcome. Read More

J Infect Dis 2018 Dec 15. Epub 2018 Dec 15.

Department of Microbiology, University of Chicago, Illinois.

Staphylococcusaureus persistently colonizes the nasopharynx of about one-third of the human population, a key risk factor for community- and hospital-acquired invasive infections. Current strategies for S. aureus decolonization include topical and systemic administration of antibiotics, which is associated with selection for antibiotic resistance and posttreatment recolonization. Read More

Nucleic Acids Res 2018 Dec 15. Epub 2018 Dec 15.

Université de Rennes 1, Inserm, BRM (Bacterial Regulatory RNAs and Medicine) UMR_S 1230, 35000 Rennes, France.

Toxin-antitoxin (TA) systems are ubiquitous among bacteria, frequently expressed in multiple copies, and important for functions such as antibiotic resistance and persistence. Type I TA systems are composed of a stable toxic peptide whose expression is repressed by an unstable RNA antitoxin. Here, we investigated the functionalities, regulation, and possible cross-talk between three core genome copies of the pathogenicity island-encoded 'sprG1/sprF1' type I TA system in the human pathogen Staphylococcus aureus. Read More

Colloids Surf B Biointerfaces 2018 Dec 4;175:281-290. Epub 2018 Dec 4.

Department of Materials Science and Engineering, Indian Institute of Technology, Delhi, 110016, India. Electronic address:

Biodegradable polymer based 'controlled release packaging' technology has ability to release packaging actives in controlled manner to prolong the food shelf-life. Currently available systems are not sufficiently capable of releasing multiple actives in sustainable fashion. Hence, the purpose of this study was to develop dual actives (antioxidant and antibacterial) loaded multilayered microparticles in one step and to release them at rates suitable for long-term inhibition of bacterial growth as well as lipid oxidation in food. Read More

J Infect 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China. Electronic address:

Objectives: Bacterial meningitis remains one of the major challenges in infectious diseases, leading to sequel in many cases. A prompt diagnosis of the causative microorganism is critical to significantly improve outcome of bacterial meningitis. Although various targeted tests for cerebrospinal fluid (CSF) samples are available, it is a big problem for the identification of etiology of bacterial meningitis. Read More

J Chem Theory Comput 2018 Dec 14. Epub 2018 Dec 14.

Correlations between the nonequilibrium solvation dynamics upon the photon excitation of the chromophore and system's equilibrium fluctuations are deeply studied. As linear response of the solvent has been linked with Gaussian statistics of the energy fluctuations in literatures, we specifically explore the cases beyond the regime of the linear response theory due to deviation from Gaussian fluctuations. As a continuation of our previous work, an analytical formalism is presented to project the energy shift with various order moments, where the non-Gaussian statistics arise from the overlap of the energy basins on the perturbed potential energy surface. Read More

Klin Lab Diagn 2018 ;63(1):60-64

The Federal budget institution of science "The state scientifc center of applied microbiology and biotechnology" of the Rospotrebnadzor, 142279, Obolensk, Moscow oblast, Russia.

The article presents the results of studying molecular genetic mechanisms of development of resistance to antiseptic Triclosan in strain Staphylococcus aureus АТСС25923. The modifcations of strain S. aureus АТСС25923 (Tr1, Tr2, Tr1С и Tr2С) are obtained resistant to 64 mg/l of Triclosan and stably preserving the given characteristic under cultivation in absence of selective pressure. Read More

Trop Med Int Health 2018 Dec 14. Epub 2018 Dec 14.

Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu, Univ Estadual Paulista, Botucatu, Brazil.

Objective: To evaluate the molecular epidemiology and to georeference Staphylococcus aureus isolated from wounds and nares of patients seen at Basic Health Units (BHUs) of a Brazilian city.

Methods: Observational, cross-sectional study conducted from 2010 to 2013. A total of 119 S. Read More

J Biomed Mater Res B Appl Biomater 2018 Dec 13. Epub 2018 Dec 13.

Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics (CMPG), KU Leuven, Kasteelpark Arenberg 20 Box 2460, 3001 Leuven, Belgium.

Biofilms, especially those formed by Staphylococcus aureus, play a key role in the development of orthopedic implant infections. Eradication of these infections is challenging due to the elevated tolerance of biofilm cells against antimicrobial agents. In this study, we developed an antibiofilm coating consisting of 5-(4-bromophenyl)-N-cyclopentyl-1-octyl-1H-imidazol-2-amine, designated as LC0024, covalently bound to a titanium implant surface (LC0024-Ti). Read More

J Leukoc Biol 2018 Dec 13. Epub 2018 Dec 13.

Inflammation Program and Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA, 52240, USA.

Microbial infection elicits robust immune responses that initially depend on polymorphonuclear neutrophils (PMN), which ingest and kill invading bacteria. However, community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) remain viable within PMN and prompt their lysis with concomitant release of damage-associated molecular patterns and proinflammatory cytokines that promote additional inflammation. Here, we show that ultrapure human PMN (>99. Read More

J Cosmet Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Beijing Key Lab of Plant Resources Research and Development, College of Science, Beijing Technology and Business University, Beijing, China.

Background/aims: Healthy skin harbors numerous microbes known to maintain its health and prevent attacks from external pathogens. The influence of chemical preservatives commonly used in cosmetic products on facial resident flora remains poorly characterized. In this study, we aimed to investigate the antibacterial activity of five such preservatives on in vitro cultivated skin-resident bacteria. Read More

Vet Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, 5371, Australia.

Background: An antibiotic adjuvant is a chemical substance used to modify or augment the effectiveness of primary antimicrobial agents against drug-resistant micro-organisms. Its use provides an alternative approach to address the global issue of antimicrobial resistance and enhance antimicrobial stewardship.

Hypothesis/objectives: To determine the antimicrobial activity of a panel of potential antimicrobial adjuvants against common pathogens associated with canine otitis externa (OE). Read More

Pediatr Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University of California, San Diego School of Medicine, San Diego, California.

Most guidelines on neonatal skin care emphasize issues pertaining to healthy, term infants. Few address the complex task of skin barrier maintenance in preterm, very preterm, and extremely preterm infants. Here, we provide an evidence-based review of the literature on skin care of preterm neonates. Read More

Chem Biodivers 2018 Dec 12. Epub 2018 Dec 12.

University of Toyama, Institute of Natural Medicine, 2330-Sugitani, Not Available, 930-0194, Toyama, JAPAN.

A new tribromoiododiphenyl ether (1) and eight known brominated diphenyl ethers (2-9) were isolated from the MeOH extract of the sponge Arenosclera sp. collected in Vietnam, using repeated open column chromatography and preparative thin layer chromatography. The chemical structure of the new compound was determined by analyses of spectroscopic (1D- and 2D-NMR, and MS) data and by comparison of our data with those reported in the literature. Read More

J Food Sci 2018 Dec 12. Epub 2018 Dec 12.

Authors Elahi and Fujikawa are with The United Graduate School of Veterinary Sciences, Gifu Univ.,, Fuchu, Tokyo, 183-8509, Japan.

Staphylococcus aureus food poisoning, which is still a serious health problem worldwide, is caused by the intoxication of staphylococcal enterotoxin (SE). Among many types of SE, staphylococcal enterotoxin type A (SEA) is known to be the most responsible for S. aureus food poisoning worldwide. Read More

Microbiol Spectr 2018 Nov;6(6)

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.

is one of the most important human pathogens that is responsible for a variety of diseases ranging from skin and soft tissue infections to endocarditis and sepsis. In recent decades, the treatment of staphylococcal infections has become increasingly difficult as the prevalence of multi-drug resistant strains continues to rise. With increasing mortality rates and medical costs associated with drug resistant strains, there is an urgent need for alternative therapeutic options. Read More

Microbiol Spectr 2018 Nov;6(6)

School of Pharmacy and Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia.

Strains of , and to a lesser extent other staphylococcal species, are a significant cause of morbidity and mortality. An important factor in the notoriety of these organisms stems from their frequent resistance to many antimicrobial agents used for chemotherapy. This review catalogues the variety of mobile genetic elements that have been identified in staphylococci, with a primary focus on those associated with the recruitment and spread of antimicrobial resistance genes. Read More

Methods Mol Biol 2019 ;1894:271-280

Department of Chemistry, University of Ioannina, Ioannina, Greece.

Nanomaterials are examined more and more for their antibacterial properties. Herein, we propose a method for assessing the bactericidal properties of nanomaterials against Escherichia coli and Staphylococcus aureus, as well as a method to investigate the metabolic alterations occurring to bacteria, induced by their exposure to nanomaterials. Bacterial metabolome is extracted and metabolic fingerprint is recorded by H-NMR. Read More

Front Pediatr 2018 28;6:360. Epub 2018 Nov 28.

Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Centre de Biologie et de Pathologie Nord, Hospices Civils de Lyon, Lyon, France.

Toxic shock syndromes (TSS) are severe shocks due to staphylococcal or streptococcal infection that require specific treatments. The early recognition of these shocks is crucial to improve their outcomes. The primary objective of this study was to compare characteristics and outcomes of staphylococcal and streptococcal TSS in children, in order to identify putative early clinical diagnostic criteria. Read More

Front Microbiol 2018 28;9:2955. Epub 2018 Nov 28.

Department of Microbiology, College of Basic Medical Sciences, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Army Medical University (Third Military Medical University), Chongqing, China.

The emergence of vancomycin-intermediate (VISA) has raised healthcare concerns worldwide. VISA is often associated with multiple genetic changes. However, the relative contributions of these changes to VISA phenotypes are incompletely defined. Read More

Front Physiol 2018 28;9:1658. Epub 2018 Nov 28.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.

Antimicrobial blue light (aBL) has attracted increasing interest for its antimicrobial properties. However, the underlying bactericidal mechanism has not yet been verified. One hypothesis is that aBL causes the excitation of intracellular chromophores; leading to the generation of reactive oxygen species (ROS) and the resultant oxidization of various biomolecules. Read More

J Conserv Dent 2018 Nov-Dec;21(6):642-645

Department of Conservative Dentistry and Endodontics, Nair Hospital Dental College, Mumbai, Maharashtra, India.

Aim: The aim is to test the antimicrobial activity of , (neem), and (curcumin) as a root canal irrigant, against and using agar diffusion test. Sodium hypochlorite (NaOCl) served as a standard control for comparisons.

Materials And Methods: The bacterial strains of and culture were grown overnight (18-20 h) in the brain heart infusion broth at 37°C and inoculated in Mueller-Hinton agar plates. Read More

Leukemia 2018 Dec 13. Epub 2018 Dec 13.

Department of Haematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Patients with chronic lymphocytic leukemia (CLL) have a high risk of bloodstream infections (BSI). BSI cause significant morbidity and mortality among CLL patients; approximately one-third of fatalities in CLL list infections as cause of death. All CLL patients in Denmark diagnosed between 2008 and 2016 were followed through registries for the event of a BSI. Read More

Am J Infect Control 2018 Dec 11. Epub 2018 Dec 11.

Virginia Commonwealth University Health System, Richmond, VA.

Background: Staphylococcal decolonization decreases the risk of Staphylococcus aureus surgical site infection. This study evaluates patient perceptions and barriers to a universal Staphylococcal decolonization (USD) protocol.

Methods: In October 2013, a protocol for the decolonization of Staphylococcal aureus in elective orthopedic, neurosurgical, and cardiac surgeries was implemented in an effort to further decrease post-operative infections rates. Read More

BMC Microbiol 2018 Dec 13;18(1):211. Epub 2018 Dec 13.

Department of Infectious Diseases and Quality Control Center of Hospital Infection Management of Shenzhen, Shenzhen Nanshan People's Hospital, Guang Dong Medical University, No 89, Taoyuan Road, Nanshan District, Shenzhen, 518052, China.

Background: Mortality rates for patients with Staphylococcus aureus (S. aureus) infections have improved only modestly in recent decades and S. aureus infections remain a major clinical challenge This study investigated the in vitro antimicrobial activity of erevacycline (erava) against clinical S. Read More

J Org Chem 2018 Dec 14. Epub 2018 Dec 14.

To gain a better understanding of the conjugation chemistry taking place at the interface of the capsular polysaccharide repeating units described herein is the synthesis of two disaccharides. These disaccharides correspond to the connection point of the repeating units of S. aureus CP5 and CP8. Read More

Antibiotics (Basel) 2018 Dec 12;7(4). Epub 2018 Dec 12.

Division of Nephrology, Department of Internal Medicine, BronxCare Hospital Center, New York, NY 10457, USA.

(1) Background: The use of intravenous antibiotics for severe infections is a common practice, either as inpatient or outpatient treatment. In the case of methicillin-susceptible (MSSA), nafcillin is a commonly prescribed intravenous antibiotic, given its known efficacy to treat infections related to this organism effectively. However, it is not without side effects. Read More

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza 12613, Egypt.

The paper describes the synthesis and biological evaluation of some new benzimidazole derivatives as potent clinical drugs that are useful in the treatment of some microbial infections and tumor inhibition. The starting compound 2-(bromomethyl)-1-benzimidazole () was prepared, and hence underwent interesting functionalization reactions to afford several series of benzimidazole-5-(aryldiazenyl)thiazole derivatives: ⁻, ⁻, and ⁻. The antibacterial activities of the synthesized compounds were evaluated by calculation of the inhibition zone diameter (mm) and the determination of minimum inhibitory concentration (µg/mL) against selected pathogenic bacteria (Gram-positive bacteria) and (Gram-negative bacteria). Read More