796,483 results match your criteria Standards in genomic sciences[Journal]


CytoML for cross-platform cytometry data sharing.

Cytometry A 2018 Dec;93(12):1189-1196

Program in Biostatistics Bioinformatics and Epidemiology, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Western Australia.

CytoML is an R/Bioconductor package that enables cross-platform import, export, and sharing of gated cytometry data. It currently supports Cytobank, FlowJo, Diva, and R, allowing users to import gated cytometry data from commercial platforms into R. Once data are available in R, the data can be further manipulated. Read More

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December 2018
1 Read

National survey: Developing a common approach to grading of practice in pre-registration midwifery.

Nurse Educ Pract 2018 Nov 26;34:150-160. Epub 2018 Nov 26.

University College London, Gower St, Bloomsbury, London, WC1E 6BT, United Kingdom. Electronic address:

This paper presents the final phase of a national project exploring grading of practice in programmes leading to registration as a midwife in the United Kingdom. The aim was to develop a generic framework for grading practice, enhancing standardisation while enabling flexibility in application of current and new educational standards. A mixed method on-line survey considered existing practice assessment tools, factors contributing to robust and reliable assessment and perceptions of two assessment tools developed by the research team: a 'Lexicon Framework' and 'Rubric', which were tested through scenarios. Read More

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November 2018

Design and methodology of a cluster-randomized trial in early care and education centers to meet physical activity guidelines: Sustainability via Active Garden Education (SAGE).

Contemp Clin Trials 2018 Dec 11. Epub 2018 Dec 11.

Center for Health Promotion and Disease Prevention, College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, United States.

Strategies are needed to help early care and education centers (ECEC) comply with policies to meet daily physical activity and fruit and vegetable guidelines for young children. This manuscript describes the design and methodology of Sustainability via Active Garden Education (SAGE), a 12-session cluster-randomized controlled crossover design trial using community-based participatory research (CBPR) to test a garden-based ECEC physical activity and fruit and vegetables promotion intervention for young children aged 3-5 years in 20 sites. The SAGE curriculum uses the plant lifecycle as a metaphor for human development. Read More

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December 2018

Unbiased Measurement of Phosphate and Phosphorus Speciation in Surface Waters.

Environ Sci Technol 2018 Dec 14. Epub 2018 Dec 14.

Trace-level phosphate analysis and phosphorus speciation in surface water remained challenging due to adsorption and phosphate uptake by microorganisms. In this study a two-dimensional ion chromatography separation coupled to electrospray ionization high-resolution mass spectrometry (2D-IC-ESI-MS) allowed isotope dilution quantitation of phosphate with simultaneous analysis of eleven phosphate-containing metabolites and two inorganic condensed phosphates. Samples were collected from Lake St. Read More

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December 2018

Interdependences between finger movement direction and haptic perception of oriented textures.

PLoS One 2018 14;13(12):e0208988. Epub 2018 Dec 14.

Department of General Psychology, Justus-Liebig University, Giessen, Germany.

Although the natural haptic perception of textures includes active finger movements, it is unclear how closely perception and movements are linked. Here we investigated this question using oriented textures. Textures that are composed of periodically repeating grooves have a clear orientation defined by the grooves. Read More

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December 2018

Psychometric Evaluation of an Instrument to Measure Prospective Pregnancy Preferences: The Desire to Avoid Pregnancy Scale.

Med Care 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, Bixby Center for Global Reproductive Health, Advancing New Standards in Reproductive Health (ANSIRH), University of California, San Francisco, School of Medicine, San Francisco.

Background: Existing approaches to measuring women's pregnancy intentions suffer important limitations, including retrospective assessment, overly simple categories, and a presumption that all women plan pregnancies. No psychometrically valid scales exist to prospectively measure the ranges of women's pregnancy preferences.

Materials And Methods: Using a rigorous construct modeling approach, we developed a scale to measure desire to avoid pregnancy. Read More

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December 2018
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Cost implications for automaker compliance of Zero Emissions Vehicle requirements.

Environ Sci Technol 2018 Dec 14. Epub 2018 Dec 14.

While there are many automotive regulations in the United States, few studies in the literature examine the interaction between different rules. We investigate the cost implications of enforcing the national Corporate Average Fuel Economy (CAFE) and greenhouse gas (GHG) emissions standards and the Zero Emissions Vehicle (ZEV) requirements simultaneously. We construct a new "Cost Optimization Modeling for Efficiency Technologies" (COMET) to understand how vehicle manufacturers implement fuel economy technologies to comply with multiple regulations. Read More

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December 2018

Blood Lithium Monitoring Practices in a Population-Based Sample of Older Adults.

J Clin Psychiatry 2018 Nov 20;79(6). Epub 2018 Nov 20.

Institute for Clinical Evaluative Sciences, London, Ontario, Canada.

Objective: Lithium is an effective treatment for mood disorders, but lithium level and renal monitoring every 3 months is recommended in older patients treated with lithium to prevent serious adverse events. This study examined lithium monitoring practices in a large geriatric cohort.

Methods: This population-based cohort study (N = 11,006) used linked health care administrative databases. Read More

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November 2018
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Several Polyphosphate Kinase 2 Enzymes Produce Adenosine 5'-Polyphosphates.

Chembiochem 2018 Dec 14. Epub 2018 Dec 14.

GERMANY.

Polyphosphate kinases (PPK) are involved in many metabolic processes; enzymes of the second family (PPK2) are responsible for nucleotide synthesis under the consumption of inorganic polyphosphate. They phosphorylate nucleotides with a varying number of phosphate residues, such as monophosphates or diphosphates. Hence, these enzymes are promising candidates for cofactor regeneration systems. Read More

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December 2018

Reimbursement pricing for new medical devices in Japan: Is the evaluation of innovation appropriate?

Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.

Department of Economics, Hosei University, Tokyo, Japan.

Objectives: In Japan, strong reimbursement pricing control measures for existing medical device products have rendered new medical device reimbursement pricing critical for manufacturers. Few studies have been conducted on this aspect; therefore, this paper (1) clarifies whether evaluation of innovation is appropriate or not and (2), if not, investigates its background.

Methods: In this research, 319 C1/C2 government decisions for new medical devices in the 10 years from April 2008 to March 2018 were analyzed. Read More

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December 2018

A Systematic Review of Ayres Sensory Integration Intervention for Children with Autism.

Autism Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Occupational Therapy Jefferson, College of Health Professions Faculty, Farber Institute for Neurosciences Thomas Jefferson University Philadelphia, Pennsylvania.

Sensory integration is one of the most highly utilized interventions in autism, however, a lack of consensus exists regarding its evidence base. An increasing number of studies are investigating the effectiveness of this approach. This study used the Council for Exceptional Children (CEC) Standards for Evidence-based Practices in Special Education to evaluate the effectiveness research from 2006 to 2017 on Ayres Sensory Integration (ASI) intervention for children with autism. Read More

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December 2018
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Integrated internal standards: A sample prep-free method for better precision in microchip CE.

Electrophoresis 2018 Dec 13. Epub 2018 Dec 13.

BIOS-Lab on a Chip Group, MESA+ Institute of Nanotechnology, TechMed Centre and Max Planck Center for Complex Fluid Dynamics, University of Twente, Enschede, Overijssel, The Netherlands.

Point-of-care systems based on microchip capillary electrophoresis require single-use, disposable microchips pre-filled with all necessary solutions so an untrained operator only needs to apply the sample and perform the analysis. While microchip fabrication can be (and has been) standardized, some manufacturing differences between microchips are unavoidable. To improve analyte precision without increasing device costs or introducing additional error sources, we recently proposed the use of integrated internal standards (ISTDs): ions added to the BGE in small concentrations which form system peaks in the electropherogram that can be used as a measurement reference. Read More

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December 2018

Foetal growth standards: Description, prescription, or prediction?

Authors:
Michael S Kramer

Paediatr Perinat Epidemiol 2018 Dec 12. Epub 2018 Dec 12.

Departments of Pediatrics and of Epidemiology, Biostatistics and Occupation Health, McGill University Faculty of Medicine, Montreal, Quebec, Canada.

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December 2018

Periprocedural pulmonary aspiration: An analysis of medical malpractice cases and alleged causative factors.

J Eval Clin Pract 2018 Dec 12. Epub 2018 Dec 12.

Department of Anesthesiology, Cardiac Division, Yale University School of Medicine, New Haven, Connecticut.

Rationale Aims And Objectives: Pulmonary aspiration is a feared complication of anaesthesia that is associated with significant morbidity and mortality. Within the small existing body of literature on medical malpractice claims related to periprocedural aspiration, very little information is available regarding the case-specific factors that were alleged to contribute to each aspiration event.

Methods: This study searched an extensive nationwide database of medical malpractice claims and identified 43 relating to periprocedural pulmonary aspiration. Read More

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December 2018

Discovery and characterisation of lycorine-type alkaloids in Lycoris spp. (Amaryllidaceae) using UHPLC-QTOS-MS.

Phytochem Anal 2018 Dec 11. Epub 2018 Dec 11.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, P.R. China.

Introduction: Lycorine, one of the most common alkaloids in Lycoris spp., is believed to possess pharmacological activity.

Objective: To discover and identify lycorine-type alkaloids in the crude extracts of bulbs from six Lycoris spp. Read More

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December 2018

Analysis of condensed tannins in Populus spp. using reversed phase UPLC-PDA-(-)esi-MS following thiolytic depolymerisation.

Phytochem Anal 2018 Dec 11. Epub 2018 Dec 11.

Department of Entomology, University of Wisconsin-Madison, Madison, WI, USA.

Introduction: Condensed tannins (CTs) are proanthocyanidin heteropolymers that are widely distributed among plants. Their biochemical properties are determined by molecular structure (e.g. Read More

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December 2018

Influence of canine donor plasma hemostatic protein concentration on quality of cryoprecipitate.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Cryoprecipitate (CRYO) is a plasma component containing high concentrations of factor VIII (FVIII), von Willebrand factor (VWF), and fibrinogen. Because Greyhounds are reported to have lower plasma VWF and fibrinogen concentrations, their plasma may not yield high potency CRYO.

Objectives: To determine if plasma hemostatic protein concentration is a good predictor of CRYO potency and if a difference exists in quality of CRYO prepared from Greyhounds versus non-Greyhounds. Read More

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December 2018

New graduate occupational therapists' narratives of ethical tensions encountered in practice.

Aust Occup Ther J 2018 Dec 11. Epub 2018 Dec 11.

School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Background/aim: Professionals in health and social care have high workloads and are working with diverse populations in hierarchical and complicated service delivery systems. There is increasing pressure on new graduates because they are expected to be immediately work ready and may not receive adequate support or supervision. It is well known that there can be issues with satisfaction and retention rates of new graduates due to the challenges they experience. Read More

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December 2018

Synthesis of C-labelled sulfated N-acetyl-d-lactosamines to aid in the diagnosis of mucopolysaccharidosis diseases.

J Labelled Comp Radiopharm 2018 Nov 22. Epub 2018 Nov 22.

Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.

Morquio A syndrome is an autosomal mucopolysaccharide storage disorder that leads to accumulation of keratan sulfate. Diagnosis of this disease can be aided by measuring the levels of keratan sulfate in the urine. This requires the liquid chromatography tandem mass spectrometry (LCMS/MS) measurement of sulfated N-acetyl-d-lactosamines in the urine after cleavage of the keratan sulfate with keratanase II. Read More

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November 2018

Mass Defect Filtering for Suspect Screening of Halogenated Environmental Chemicals: A Case Study of Chlorinated Organophosphate Flame Retardants.

Rapid Commun Mass Spectrom 2018 Dec 11. Epub 2018 Dec 11.

Exposure Biology, Senator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Rationale: Organophosphate flame retardants (OPFRs) are a class of flame retardants widely found in environmental and biological matrices that have been extensively studied due to their adverse health effects in humans. OPFRs are loosely bound chemicals that can detach from treated products and be released into indoor and outdoor environments, where they have the potential to further undergo transformation and degradation processes, in particular the chlorinated OPFRs (Cl-PFRs). Their detection remains a moving target for analysts, and traditional targeted mass spectrometry methods are suitable only for those compounds with authentic standards. Read More

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December 2018

Self-Efficacy for Management of Symptoms and Symptom Distress in Adults With Cancer: An Integrative Review.

Oncol Nurs Forum 2019 Jan;46(1):113-128

University of Nebraska Medical Center.

Problem Identification: Self-efficacy for symptom management plays a key role in outcomes, such as quality of life (QOL), functional status, and symptom distress, for adults with cancer. This integrative review identified and assessed evidence regarding self-efficacy for management of symptoms and symptom distress in adults with cancer.

Literature Search: The authors performed a search of literature published from 2006-2018, and articles that examined the relationship among self-reported self-efficacy, symptom management, symptom distress or frequency, and severity in adults with cancer were selected for inclusion. Read More

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January 2019

Update on the diagnosis and management of acute heart failure.

Curr Opin Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiology, Canadian VIGOUR Centre, University of Alberta, Edmonton.

Purpose Of Review: To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies.

Recent Findings: We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Read More

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December 2018

Posterior cord syndrome associated with postoperative seroma: The case to perform a complete neurologic exam.

J Spinal Cord Med 2018 Dec 14:1-3. Epub 2018 Dec 14.

b Physical Medicine and Rehabilitation Department , Tufts Medical Center , Boston , Massachusetts , USA.

Context: Posterior cord syndrome (PCS) is the least common incomplete spinal cord injury. Findings of posterior cord syndrome include loss of proprioception and vibration, which are not routinely tested with the American Spinal Cord Injury Association's International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) exam and can easily be missed. Seromas may develop after spinal instrumentation and can cause cord compression. Read More

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December 2018

National Survey Of The Aetiological Assessment Service Of Permanent Childhood Hearing Loss In Ireland

Ir Med J 2018 09 10;111(8):804. Epub 2018 Sep 10.

Department of Paediatrics, St Luke’s General Hospital, Kilkenny

Aim The Universal Neonatal Hearing Screening Programme (UNHS) was implemented nationally in 2014. All infants identified with permanent childhood hearing loss (PCHL) should have a paediatric assessment performed. This survey aimed to assess available paediatric services and to inform service development. Read More

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September 2018

Compendium of the Health and Wellness Coaching Literature.

Am J Lifestyle Med 2018 Nov-Dec;12(6):436-447. Epub 2017 May 19.

Department of Exercise & Sport Sciences, Ithaca College, Ithaca, New York (GAS, SH, KC, LC).

Health and wellness coaching (HWC) for lifestyle behavior change is emerging as a practice, role, and profession, in diverse health care, employee wellness, and community settings. Health care professionals apply HWC as a behavior change methodology for the prevention and treatment of diabetes, hypertension, hyperlipidemia, heart disease, cancer, and other chronic disorders. The purpose of this systematic review was to provide a comprehensive and organized compendium of HWC literature. Read More

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A Market Basket Survey of Horticultural Fruits for Arsenic and Trace Metal Contamination in Southeast Nigeria and Potential Health Risk Implications.

J Health Pollut 2017 Sep 7;7(15):40-50. Epub 2017 Sep 7.

School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.

Background: Elevated arsenic and trace metal contamination of the terrestrial food chain represents one of the most significant environmental risk exposures for human populations in developing countries. Metalloid and metal contamination in horticultural crop produce such as fruit is a public health concern in Nigeria. Local fruits are cheap sources of vitamins and minerals for the resident population and pose an important dietary threat of metal(loid) toxicity through consumption. Read More

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September 2017

Heavy Metal Contamination of Ground Water from an Unlined Landfill in Bulawayo, Zimbabwe.

J Health Pollut 2017 Sep 7;7(15):18-27. Epub 2017 Sep 7.

Department of Environmental Science and Health, National University of Science and Technology, Bulawayo, Zimbabwe.

Background: Developing countries such as Zimbabwe deal with challenges in solid waste management such as insufficient waste recycling, hazardous wastes that are not separated for safe disposal, and landfills that are not properly engineered to prevent groundwater pollution. For these reasons, landfills in developing countries pose serious environmental and public health hazards.

Objectives: The objective of this study was to assess heavy metal release and groundwater pollution from an unlined landfill in Bulawayo, Zimbabwe. Read More

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September 2017

Assessment of Heavy Metal Concentrations in Pawpaw (Carica papaya Linn.) around Automobile Workshops in Port Harcourt Metropolis, Rivers State, Nigeria.

J Health Pollut 2017 Jun 22;7(14):48-61. Epub 2017 Jun 22.

Department of Geography and Environmental Management, University of Port Harcourt, Port Harcourt, Nigeria.

Background: Consumption of plants such as Carica papaya grown around automobile workshops is common in big cities in Nigeria. However, little is known about the heavy metals contamination of these consumables due to the influence of automobile emissions during maintenance activities.

Objectives: This study aimed to assess heavy metal concentrations in C. Read More

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Environmental Working Conditions, Lung Function and Total Serum Bile Acids of Spray Painters Exposed to Organic Solvents in Ile-Ife, Nigeria.

J Health Pollut 2017 Mar 29;7(13):2-10. Epub 2017 Mar 29.

Department of Chemical Engineering, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

Background: Nigeria has a growing spray painting industry, however, the burden of occupational health problems related to organic solvent exposure among spray painters in Nigeria is under-studied.

Objectives: This study aimed to assess workshop characteristics and ambient concentration of total volatile organic compounds (VOCs) in spray painting workshops and to compare lung function status and total serum bile acid levels of spray painters and controls.

Methods: A cross-sectional study design was employed to survey 120 spray painters and 120 controls (electronic technicians). Read More

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Examination of Lead and Cadmium in Water-based Paints Marketed in Nigeria.

J Health Pollut 2016 Dec 22;6(12):43-49. Epub 2016 Dec 22.

CSIR-National Environmental Engineering and Research Institute, Nagpur, India.

Background: In spite of the availability of substitutes for lead and cadmium compounds in paints, manufacturers continue to produce paints with high levels of these metals. As the population continues to grow and there is a continued shift from oil-based to water-based paints, the sales and use of these paints will increase the exposure of humans and the environment to these metals.

Objectives: We measured the levels of lead (Pb) and cadmium (Cd) in 174 paint samples marketed in Lagos and Ibadan, Nigeria. Read More

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December 2016

Review of Particulate Matter and Elemental Composition of Aerosols at Selected Locations in Nigeria from 1985-2015.

J Health Pollut 2016 Jun 17;6(10):1-18. Epub 2016 Jun 17.

Department of Environmental Health, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Over the past 30 years, various studies in Nigeria have monitored atmospheric particulate matter loads and elemental composition of ambient air around diverse receptor sites.

Objectives: A comparative discussion of the different sampling techniques, pre-treatment and analytical methods employed between 1985 and 2015.

Methods: Air pollution indices from studies covered in this review were compared to relevant guideline standards such as the World Health Organization (WHO) 24-hr guideline and the United States Environmental Protection Agency (USEPA)'s National Ambient Air Quality Standard (NAAQS) daily permissible limits for fine particles of less than 2. Read More

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June 2016
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Public Health Risk Assessment of Heavy Metal Uptake by Vegetables Grown at a Waste-water-Irrigated Site in Dhaka, Bangladesh.

J Health Pollut 2015 Dec 21;5(9):78-85. Epub 2015 Dec 21.

Analytical Research Division, Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh.

Background: Wastewater is often used in developing countries for irrigation of crops. This wastewater often contains a number of heavy metals which are harmful to human health due to their non-biodegradable nature, long biological half-lives and their potential to accumulate in different body parts. There are many potential risks to human health from heavy metal contamination of vegetables grown at waste-water-irrigated sites. Read More

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December 2015

Soil Contamination with Heavy Metals around Jinja Steel Rolling Mills in Jinja Municipality, Uganda.

J Health Pollut 2015 Dec 21;5(9):61-67. Epub 2015 Dec 21.

Quality Control Department, Abacus Pharmaceutical, Mukono, Uganda.

Background: Soil contamination with heavy metals has severely increased over the last few decades, mainly from industrial wastes and human activities. Soil pollution is a source of danger to the health of people globally.

Objectives: To assess the level of soil contamination with heavy metals around steel rolling mills in Jinja municipality, Uganda. Read More

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December 2015
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Mercury and Lead Contamination in Three Fish Species and Sediments from Lake Rukwa and Catchment Areas in Tanzania.

J Health Pollut 2015 Jun 2;5(8):7-18. Epub 2015 Jul 2.

Department of Animal Science and Production, Sokoine University of Agriculture, P.O Box 3004, Morogoro, Tanzania.

Background: Mining activity in the catchment area of Tanzania's Lake Rukwa is suspected of adding to the lake and connected rivers' heavy metal load. There has been no study done, however, on the levels of mercury (Hg) and lead (Pb) in lake sediment and fish muscle, and what the results could mean for human health.

Objectives: This study investigated the concentration of Hg and Pb in lake sediment and in the muscles of African sharptooth catfish (Clarias gariepinus), Lake Rukwa tilapia (Oreochromis rukwaensis) and Singida tilapia (Oreochromis esculentus) from Tanzania's Lake Rukwa and connected rivers. Read More

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Chemical compositional standards for non-lead hunting ammunition and fishing weights.

Authors:
Vernon G Thomas

Ambio 2018 Dec 13. Epub 2018 Dec 13.

Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, ON, N1G 2W1, Canada.

The chemical composition of non-lead, non-toxic, gunshot used for hunting waterfowl is regulated only in Canada and the USA. No nation regulates the composition of non-lead fishing weights, rifle bullets, and gunshot used for upland game hunting. Compositional criteria for these non-lead products are proposed here, based on established experimental toxicity protocols. Read More

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December 2018

Functional significance of channelopathy gene variants in unexplained death.

Forensic Sci Med Pathol 2018 Dec 13. Epub 2018 Dec 13.

Pediatrics, NYU School of Medicine, 450 E 29th Street, ACLS 824, New York, NY, 10016, USA.

Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple risk model proposed for sudden infant death syndrome involves the intersection of three risks: (1) a critical developmental period in homeostatic control (2), exogenous stressors, and (3) a vulnerable infant. Even though sex and age factor into some forms of inherited arrhythmogenic deaths in young individuals and adults, more appropriate a dual-risk disease model for adults involves exogenous stressors and a vulnerable individual. Read More

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December 2018
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Data in support for the measurement of heparan sulfate and dermatan sulfate by LC-MS/MS analysis.

Data Brief 2018 Dec 26;21:2398-2404. Epub 2018 Nov 26.

Newborn Screening, Biochemistry and Pharmacology Laboratory, Pediatric Neurology Unit and Laboratories, Meyer Children׳s University Hospital, Florence, Italy.

This article provides supplementary data for the paper "LC-MS/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization" (Forni et al., 2018). Several parameters were tested to optimize sample preparation by butanolysis in order to carry out simultaneous quantifications of HS and DS by tandem mass spectrometry. Read More

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December 2018

Lentiviral Vector Purification Using Genetically Encoded Biotin Mimic in Packaging Cell.

Mol Ther Methods Clin Dev 2018 Dec 23;11:155-165. Epub 2018 Oct 23.

UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.

Lentiviral vectors (LVs) have recently witnessed an increasing demand in research and clinical applications. Their current purification processes represent the main bottleneck in their widespread use, as the methods used are cumbersome and yield low recoveries. We aimed to develop a one-step method to specifically purify LVs, with high yields and reduced levels of impurities, using the biotin-streptavidin system. Read More

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December 2018

Durian Fruits Discovered as Superior Folate Sources.

Front Nutr 2018 28;5:114. Epub 2018 Nov 28.

Chair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.

Durian () is a tropical fruit grown in Southeast Asia and highly appreciated by consumers throughout Asia. Folates are a group of vitamins and are essential nutrients for humans. Here we present the folate analysis of different durian cultivars as well as diverse durian products. Read More

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November 2018

Hysterectomy for the Management of Menstrual Hygiene in Women With Intellectual Disability. A Systematic Review Focusing on Standards and Ethical Considerations for Developing Countries.

Front Public Health 2018 28;6:338. Epub 2018 Nov 28.

Policy Studies Center of the College of Public Policy, University of Texas at San Antonio, San Antonio, TX, United States.

Menstruation poses particular challenges for women with intellectual disability (ID). In low-and middle-income countries, where these women do not have access to facilities and resources for adequate menstrual care, hysterectomy could be considered as an ethically acceptable procedure. We conducted the first systematic review to identify what constitutes best practice for menstrual hygiene in women with ID and explored the perspectives of actors involved in the hysterectomy decision. Read More

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November 2018

Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers.

Front Oncol 2018 28;8:563. Epub 2018 Nov 28.

Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Head and neck cancer is the 6th most common malignancy worldwide and urgently requires novel therapy methods to change the situation of low 5-years survival rate and poor prognosis. Targeted therapy provides more precision, higher efficiency while lower adverse effects than traditional treatments like surgery, radiotherapy, and chemotherapy. Blockade of PD-1 pathway with antibodies against PD-1 or PD-L1 is such a typical targeted therapy which reconstitutes anti-tumor activity of T cell in treatments of cancers, especially those highly expressing PD-L1, including head and neck cancers. Read More

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November 2018

Small Esophageal Varices in Patients with Cirrhosis-Should We Treat Them?

Curr Hepatol Rep 2018 7;17(4):301-315. Epub 2018 Nov 7.

1Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The natural history and classification systems of small varices (≤ 5 mm in diameter) in cirrhotic patients with portal hypertension are summarized. Studies that assessed the course of and therapeutic intervention for small varices are discussed.

Recent Findings: Current non-invasive methods show suboptimal sensitivity to detect small varices in patients with cirrhosis. Read More

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November 2018

Regional working in the East of England: using the UK National Standards for Public Involvement.

Res Involv Engagem 2018 6;4:48. Epub 2018 Dec 6.

1Centre for Research in Public Health and Community Care (CRIPACC), University of Hertfordshire, Hatfield, AL10 9AB UK.

Plain English Summary: Involving patients and members of the public to help shape and carry out research is recommended in health research in the United Kingdom (UK). There are a number of regional networks of Patient and Public Involvement (PPI) groups, which support the collaboration between researchers, patients and public members. We are a group of researchers, patients and public members who came together via a PPI regional network in the East of England to collaborate on a research study about the extent of feedback from researchers to PPI contributors. Read More

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December 2018
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Community Violence and Associated Psychological Problems Among Adolescents in the General Population.

J Child Adolesc Trauma 2018 2;11(4):411-420. Epub 2018 Jun 2.

4School of Social Work, Université de Montréal, Montréal, Canada.

Based on a populational survey conducted among 1400 adolescents aged between 12 and 17 years old, the aim of this study is to assess the relationships between their community violence experiences and their psychological health (anger, depressive symptoms, and post-traumatic stress disorder symptoms). One MANOVA confirms that both boys and girls who report at least one incident of physical community violence present more psychological difficulties, especially anger. Subsequent MANOVAs show that anger intensity varies depending on whether the youth was a direct victim or a witness only, as well as on the diversity of the types of violent manifestations and on acquaintance with the perpetrator, whereas the presence of injuries has no significant effect. Read More

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Overweight and obesity in preschool aged children and risk of mental health service utilization.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Objective: To determine if overweight or obesity in preschool-age children is associated with mental health service utilization in later childhood.

Subjects: Overall, 10,522 children 2 to <5 years, with no previous history of mental health service utilization, were identified from primary care electronic medical records (EMRs) across Ontario, Canada.

Methods: This was a retrospective longitudinal cohort study. Read More

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December 2018
2 Reads

A public health framework for the regulation of marketing.

J Public Health Policy 2018 Dec 13. Epub 2018 Dec 13.

Oregon Research Institute, 1776 Millrace, Eugene, OR, 97403, USA.

Cross-sectional, longitudinal, and experimental studies have found a link between youth exposure to cigarette marketing and youth initiation of smoking. These decisive research findings led to regulations of cigarette marketing to youth-including no television or radio ads, prohibitions on the use of cartoons, bans on transit and billboard advertisements, and disallowing tobacco brand sponsorships of sporting events or concerts. Similar products that may cause more harm than benefits include alcohol, electronic cigarettes, and opioids. Read More

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December 2018

New Cancer Drug Approvals From the Perspective of a Universal Healthcare System: Analyses of the Pan-Canadian Oncology Drug Review Recommendations.

J Natl Compr Canc Netw 2018 Dec;16(12):1460-1466

CancerCare Manitoba, and University of Manitoba, Winnipeg, Manitoba, Canada.

FDA approvals do not consider cost, but they set the tone for regulatory approvals worldwide, including in countries with universal healthcare where cost-effectiveness, utility, and adoption feasibility are considered rigorously. Data from the pan-Canadian Oncology Drug Review (pCODR), a national drug review system that makes evidence-based funding recommendations to Canada's provinces and territories, were collected. Our objectives were to assess (1) temporal trends in cost and efficacy of drugs reviewed, (2) correlations among magnitude of benefits, cost, and pCODR decisions, and (3) predictors of approvals. Read More

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December 2018

The Sommerfeld ground-wave limit for a molecule adsorbed at a surface.

Science 2018 Dec 13. Epub 2018 Dec 13.

Department of Dynamics at Surfaces, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.

Using a mid-infrared emission spectrometer based on a superconducting nanowire single-photon detector (SNSPD), we observe the dynamics of vibrational energy pooling of CO adsorbed at the surface of a NaCl crystal. After exciting a majority of the CO molecules to their first vibrationally excited state (v = 1), we observe infrared emission from states up to v = 27. Kinetic Monte Carlo simulations show that vibrational energy collects in a few CO molecules at the expense of those up to eight lattice sites away by selective excitation of NaCl's transverse phonons. Read More

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December 2018
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