1,367,612 results match your criteria St. Louis Encephalitis


A retrospective audit of an elderly rehabilitation service. How effective are we?

Ir Med J 2018 09 10;111(8):810. Epub 2018 Sep 10.

Medicine for the Elderly Department, St Mary’s Hospital, Phoenix Park, Dublin, Ireland.

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September 2018

Ovarian Cancer Screening Editorial

Ir Med J 2018 09 10;111(8):798. Epub 2018 Sep 10.

Mater Misericordiae Hospital, Eccles St., Dublin 7

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September 2018

Chemical compositional standards for non-lead hunting ammunition and fishing weights.

Authors:
Vernon G Thomas

Ambio 2018 Dec 13. Epub 2018 Dec 13.

Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, ON, N1G 2W1, Canada.

The chemical composition of non-lead, non-toxic, gunshot used for hunting waterfowl is regulated only in Canada and the USA. No nation regulates the composition of non-lead fishing weights, rifle bullets, and gunshot used for upland game hunting. Compositional criteria for these non-lead products are proposed here, based on established experimental toxicity protocols. Read More

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December 2018

TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1.

J Mol Neurosci 2018 Dec 13. Epub 2018 Dec 13.

Department of Biochemistry, Western University, Medical Sciences Building, Rm 342, 1151 Richmond St. North, London, ON, N6A 5C1, Canada.

Brain-derived neurotrophic factor (BDNF) facilitates multiple aspects of neuronal differentiation and cellular physiology by activating the high-affinity receptor tyrosine kinase, TrkB. While it is known that both BDNF and TrkB modulate cellular processes involved in learning and memory, exactly how TrkB cross-talks and modulates signaling downstream of excitatory ionotropic receptors, such as the NMDA receptor (NMDAR), are not well understood. A model that we have investigated involves the signaling molecule RasGrf1, a guanine nucleotide exchange factor for both Ras and Rac. Read More

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December 2018

Use, timing and outcome of coronary angiography in patients with high-risk non-ST-segment elevation acute coronary syndrome in daily clinical practice: insights from a 'real world' prospective registry.

Neth Heart J 2018 Dec 13. Epub 2018 Dec 13.

Isala Heart Centre, Zwolle, The Netherlands.

Background: An early invasive strategy (EIS) is recommended in high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), defined as coronary angiography (CAG), within 24 h of admission. The aim of the present study is to investigate guideline adherence, patient characteristics associated with timing of the intervention and clinical outcome.

Methods: In a prospective registry, the use and timing of CAG and the characteristics and clinical outcome associated with timing were evaluated in high-risk ACS patients. Read More

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December 2018

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More

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December 2018
2 Reads

"Approximate number system" training: A perceptual learning approach.

Atten Percept Psychophys 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Wisconsin-Madison, 1202 W. Johnson St., Madison, WI, 53706, USA.

Recent research suggests that humans perceive quantity using a non-symbolic "number sense." This sense is then thought to provide a foundation for understanding symbolic numbers in formal education. Given this link, there has been interest in the extent to which the approximate number system (ANS) can be improved via dedicated training, as this could provide a route to improving performance in symbolic mathematics. Read More

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December 2018

Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice.

Neurochem Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiovasology, Tianjin Union Medical Center, 190 Jieyuan St., Hongqiao District, Tianjin, 300121, China.

Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Read More

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December 2018

Functional significance of channelopathy gene variants in unexplained death.

Forensic Sci Med Pathol 2018 Dec 13. Epub 2018 Dec 13.

Pediatrics, NYU School of Medicine, 450 E 29th Street, ACLS 824, New York, NY, 10016, USA.

Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple risk model proposed for sudden infant death syndrome involves the intersection of three risks: (1) a critical developmental period in homeostatic control (2), exogenous stressors, and (3) a vulnerable infant. Even though sex and age factor into some forms of inherited arrhythmogenic deaths in young individuals and adults, more appropriate a dual-risk disease model for adults involves exogenous stressors and a vulnerable individual. Read More

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December 2018
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Effect of interplay between age and low-flow duration on neurologic outcomes of extracorporeal cardiopulmonary resuscitation.

Intensive Care Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, National Taiwan University Hospital, and College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan.

Purpose: Caseloads of extracorporeal cardiopulmonary resuscitation (ECPR) have increased considerably, and hospital mortality rates remain high and unpredictable. The present study evaluated the effects of the interplay between age and prolonged low-flow duration (LFD) on hospital survival rates in elderly patients to identify subgroups that can benefit from ECPR.

Methods: Adult patients who received ECPR in our institution (2006-2016) were classified into groups 1, 2, and 3 (18-65, 65-75, and > 75 years, respectively). Read More

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December 2018

Fulfillment of expectations influence patient satisfaction 5 years after total knee arthroplasty.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 13. Epub 2018 Dec 13.

Department for Orthopaedic and Trauma Surgery, University Medicine Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Germany.

Purpose: Constant efforts have been made to improve prosthesis design in total knee arthroplasty (TKA), but a significant number of patients remain dissatisfied postoperatively. Besides poor improvement in pain or function, poor fulfillment of patients expectations were identified as contributing factors. Purpose of the study was to assess fulfillment of patients' expectations and satisfaction with TKA 5 years after surgery. Read More

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December 2018

Fetal Echocardiographic Measures to Improve the Prenatal Diagnosis of Coarctation of the Aorta.

Pediatr Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Pediatric Cardiology, Yale School of Medicine, 333 Cedar St, LLCI 302, New Haven, CT, 06510, USA.

The objective of this study is to identify fetal echocardiographic measures that predict postnatal coarctation of the aorta (CoA). A retrospective review of patients from 2013 to 2017 identified 13 cases of prenatal diagnosis of CoA confirmed postnatally and 14 cases of prenatal diagnosis of CoA with normal arches postnatally. There were 30 controls. Read More

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December 2018
1 Read

Statistical learning of anomalous regions in complex faux X-ray images does not transfer between detection and discrimination.

Cogn Res Princ Implic 2018 Dec 13;3(1):48. Epub 2018 Dec 13.

Department of Psychology, University of Minnesota, 75 East River Road, S506 Elliott Hall, Minneapolis, MN, 55455, USA.

The visual environment contains predictable information - "statistical regularities" - that can be used to aid perception and attentional allocation. Here we investigate the role of statistical learning in facilitating search tasks that resemble medical-image perception. Using faux X-ray images, we employed two tasks that mimicked two problems in medical-image perception: detecting a target signal that is poorly segmented from the background; and discriminating a candidate anomaly from benign signals. Read More

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December 2018

Mining the natural genetic variation in Arabidopsis thaliana for adaptation to sequential abiotic and biotic stresses.

Planta 2018 Dec 14. Epub 2018 Dec 14.

Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, PO Box 80056, 3508 TB, Utrecht, The Netherlands.

Main Conclusion: In this genome-wide association study, we obtained novel insights into the genetic basis of the effect of herbivory or drought stress on the level of resistance against the fungus Botrytis cinerea. In nature, plants function in complex environments where they encounter different biotic and abiotic stresses individually, sequentially or simultaneously. The adaptive response to a single stress does not always reflect how plants respond to such a stress in combination with other stresses. Read More

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December 2018

Race/ethnicity, nativity, and lifetime risk of mental disorders in US adults.

Soc Psychiatry Psychiatr Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Disparities Research Unit, Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 830, Boston, MA, 02114, USA.

Purpose: There has been no comprehensive examination of how race/ethnicity and nativity intersect in explaining differences in lifetime prevalence of mental disorders among Asian, Black, Latino, and White adults. This study aims to estimate racial/ethnic differences in lifetime risk of mental disorders and examine how group differences vary by nativity.

Methods: Survival models were used to estimate racial/ethnic and nativity differences in lifetime risk of DSM-IV anxiety, mood, and substance use disorders in a nationally representative sample of over 20,000 respondents to four US surveys. Read More

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December 2018

Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.

Objectives: Cardiac magnetic resonance (CMR) is the gold-standard modality for the assessment of left ventricular (LV) remodeling in ST-elevation myocardial infarction (STEMI) patients. However, the commonly used remodeling criteria have never been validated for hard clinical events. We therefore aimed to define clear CMR criteria of LV remodeling following STEMI with proven prognostic impact. Read More

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December 2018

Palladium-catalyzed trisallylation of benzoxazoles and 2-aryl-1,3,4-oxadiazoles with alkyne.

Chem Commun (Camb) 2018 Dec 14. Epub 2018 Dec 14.

Institut für Organische Chemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburgim Breisgau, Germany.

A Pd-catalyzed direct C-H trisallylation of azoles with alkyne has been described. A consecutive C(sp2)-H allylation/olefin isomerization/double C(sp3)-H allylation of azoles and alkyne via a palladium catalysis system proceeds efficiently to afford the corresponding C2-alkenylated azoles containing an all quaternary carbon center. Read More

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December 2018

Development of a Medicare Health Outcomes Survey Deficit-Accumulation Frailty Index and Its Application to Older Patients With Newly Diagnosed Multiple Myeloma.

JCO Clin Cancer Inform 2018 25;2018. Epub 2018 Jul 25.

Hira S. Mian, McMaster University, Hamilton, Ontario, Canada; and Tanya M. Wildes and Mark A. Fiala, Washington University School of Medicine, St. Louis, MO.

Purpose: To develop a frailty index using the Rockwood Accumulation of Deficits approach for the Medicare Health Outcomes Survey (MHOS) and apply it in a subset of older patients with newly diagnosed multiple myeloma.

Methods: Data from 2,692,361 patients without cancer, > 66 years of age, in SEER-MHOS linked databases between 1998 and 2009 were analyzed. A frailty index was constructed, resulting in a 25-item scale; cutoff values were created for individuals classified as frail. Read More

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July 2018
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Inadvertent Intravitreous Ink Injection from Subconjunctival Tattooing Causing Intraocular Inflammation and Retinal Trauma.

Ophthalmol Retina 2018 Oct 7;2(10):1080-1082. Epub 2018 Jun 7.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO (USA).

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October 2018

Dataset of single bacteria cells with different antibiotic susceptibility obtained by Raman spectroscopy.

Data Brief 2018 Dec 23;21:2430-2434. Epub 2018 Nov 23.

Immanuel Kant Baltic Federal University, A. Nevskogo St. 14, 236016 Kaliningrad, Russia.

This data article contains Raman experimental data, obtained with Horiba Jobin-Yvon LabRam HR800 spectrometer (Japan), which can be used for rapid identification of () bacteria (Beijing clade) . Data present analyzed Raman spectra of bacterial cells with various drug resistances obtained from pulmonary and extra pulmonary samples. Data can provide information about characteristic maxima of different structures in biological cell. Read More

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December 2018

Data in support for the measurement of heparan sulfate and dermatan sulfate by LC-MS/MS analysis.

Data Brief 2018 Dec 26;21:2398-2404. Epub 2018 Nov 26.

Newborn Screening, Biochemistry and Pharmacology Laboratory, Pediatric Neurology Unit and Laboratories, Meyer Children׳s University Hospital, Florence, Italy.

This article provides supplementary data for the paper "LC-MS/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization" (Forni et al., 2018). Several parameters were tested to optimize sample preparation by butanolysis in order to carry out simultaneous quantifications of HS and DS by tandem mass spectrometry. Read More

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December 2018

Lentiviral Vector Purification Using Genetically Encoded Biotin Mimic in Packaging Cell.

Mol Ther Methods Clin Dev 2018 Dec 23;11:155-165. Epub 2018 Oct 23.

UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.

Lentiviral vectors (LVs) have recently witnessed an increasing demand in research and clinical applications. Their current purification processes represent the main bottleneck in their widespread use, as the methods used are cumbersome and yield low recoveries. We aimed to develop a one-step method to specifically purify LVs, with high yields and reduced levels of impurities, using the biotin-streptavidin system. Read More

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December 2018

Foreign Body Reaction Associated With Artificial LARS Ligaments: A Retrieval Study.

Orthop J Sports Med 2018 Dec 4;6(12):2325967118811604. Epub 2018 Dec 4.

St John of God Hospital, Subiaco, Perth, Australia.

Background: Artificial ligaments have been developed and used in the treatment of ligamentous injuries since the 1970s. The early generation of artificial ligaments showed promising short-term results but resulted in high rates of rupture and inflammatory reaction in the surrounding tissues.

Purpose: To determine whether the use of Ligament Augmentation and Reconstruction System (LARS) ligaments is associated with the development of intra-articular foreign body reaction. Read More

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December 2018

Cartilage Tissue Engineering Using Stem Cells and Bioprinting Technology-Barriers to Clinical Translation.

Front Surg 2018 27;5:70. Epub 2018 Nov 27.

Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.

There is no long-term treatment strategy for young and active patients with cartilage defects. Early and effective joint preserving treatments in these patients are crucial in preventing the development of osteoarthritis. Tissue engineering over the past few decades has presented hope in overcoming the issues involved with current treatment strategies. Read More

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November 2018

Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review.

Front Nutr 2018 28;5:115. Epub 2018 Nov 28.

Exercise and Performance Nutrition Laboratory, Department of Exercise Science, Lindenwood University, St. Charles, MO, United States.

Creatine has been extensively researched and is well-supported as one of the most effective dietary supplements available. There is overwhelming support within the literature regarding the ability of creatine to augment performance following short term (5-7 days) and long-duration supplementation periods. There is also strong support for creatine regarding its safety profile and minimal risk for adverse events or any negative influence on markers of clinical health and safety. Read More

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November 2018

Durian Fruits Discovered as Superior Folate Sources.

Front Nutr 2018 28;5:114. Epub 2018 Nov 28.

Chair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.

Durian () is a tropical fruit grown in Southeast Asia and highly appreciated by consumers throughout Asia. Folates are a group of vitamins and are essential nutrients for humans. Here we present the folate analysis of different durian cultivars as well as diverse durian products. Read More

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November 2018

Hysterectomy for the Management of Menstrual Hygiene in Women With Intellectual Disability. A Systematic Review Focusing on Standards and Ethical Considerations for Developing Countries.

Front Public Health 2018 28;6:338. Epub 2018 Nov 28.

Policy Studies Center of the College of Public Policy, University of Texas at San Antonio, San Antonio, TX, United States.

Menstruation poses particular challenges for women with intellectual disability (ID). In low-and middle-income countries, where these women do not have access to facilities and resources for adequate menstrual care, hysterectomy could be considered as an ethically acceptable procedure. We conducted the first systematic review to identify what constitutes best practice for menstrual hygiene in women with ID and explored the perspectives of actors involved in the hysterectomy decision. Read More

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November 2018

Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers.

Front Oncol 2018 28;8:563. Epub 2018 Nov 28.

Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Head and neck cancer is the 6th most common malignancy worldwide and urgently requires novel therapy methods to change the situation of low 5-years survival rate and poor prognosis. Targeted therapy provides more precision, higher efficiency while lower adverse effects than traditional treatments like surgery, radiotherapy, and chemotherapy. Blockade of PD-1 pathway with antibodies against PD-1 or PD-L1 is such a typical targeted therapy which reconstitutes anti-tumor activity of T cell in treatments of cancers, especially those highly expressing PD-L1, including head and neck cancers. Read More

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November 2018

Small Esophageal Varices in Patients with Cirrhosis-Should We Treat Them?

Curr Hepatol Rep 2018 7;17(4):301-315. Epub 2018 Nov 7.

1Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The natural history and classification systems of small varices (≤ 5 mm in diameter) in cirrhotic patients with portal hypertension are summarized. Studies that assessed the course of and therapeutic intervention for small varices are discussed.

Recent Findings: Current non-invasive methods show suboptimal sensitivity to detect small varices in patients with cirrhosis. Read More

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November 2018

Ternary nanocomposites of reduced graphene oxide, polyaniline and hexaniobate: hierarchical architecture and high polaron formation.

Beilstein J Nanotechnol 2018 26;9:2936-2946. Epub 2018 Nov 26.

School of Materials and National Graphene Institute, The University of Manchester, Booth St E, Manchester M13 9PL, United Kingdom.

Nanostructured systems, such as nanocomposites, are potential materials for usage in different fields since synergistic effects of their components at the nanoscale domain may improve physical/chemical properties when compared to individual phases. We report here the preparation and characterisation of a new nanocomposite composed of polyaniline (PANI), reduced graphene oxide (rGO) and hexaniobate (hexNb) nanoscrolls. Atomic force microscopy images show an interesting architecture of rGO flakes coated with PANI and decorated by hexNb. Read More

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November 2018

Regional working in the East of England: using the UK National Standards for Public Involvement.

Res Involv Engagem 2018 6;4:48. Epub 2018 Dec 6.

1Centre for Research in Public Health and Community Care (CRIPACC), University of Hertfordshire, Hatfield, AL10 9AB UK.

Plain English Summary: Involving patients and members of the public to help shape and carry out research is recommended in health research in the United Kingdom (UK). There are a number of regional networks of Patient and Public Involvement (PPI) groups, which support the collaboration between researchers, patients and public members. We are a group of researchers, patients and public members who came together via a PPI regional network in the East of England to collaborate on a research study about the extent of feedback from researchers to PPI contributors. Read More

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December 2018

Community Violence and Associated Psychological Problems Among Adolescents in the General Population.

J Child Adolesc Trauma 2018 2;11(4):411-420. Epub 2018 Jun 2.

4School of Social Work, Université de Montréal, Montréal, Canada.

Based on a populational survey conducted among 1400 adolescents aged between 12 and 17 years old, the aim of this study is to assess the relationships between their community violence experiences and their psychological health (anger, depressive symptoms, and post-traumatic stress disorder symptoms). One MANOVA confirms that both boys and girls who report at least one incident of physical community violence present more psychological difficulties, especially anger. Subsequent MANOVAs show that anger intensity varies depending on whether the youth was a direct victim or a witness only, as well as on the diversity of the types of violent manifestations and on acquaintance with the perpetrator, whereas the presence of injuries has no significant effect. Read More

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Dynamic instability of the acromioclavicular joint: A new classification for acute AC joint separation.

Obere Extrem 2018 28;13(4):279-285. Epub 2018 Jun 28.

2Center for Musculoskeletal Surgery, Campus Virchow, Charité-Universitaetsmedizin, Berlin, Germany.

Background: Acute acromioclavicular (AC) dislocation is classified according to Rockwood (RW). Although of clinical relevance, dynamic horizontal translation (DHT) is not listed in this classification or in frequently used clinical evaluation tools. The aim of this study was (a) to evaluate vertical and horizontal AC joint instabilities and assess their combined occurrence and clinical appearance in a consecutive group of patients, as well as (b) to develop a new classification of acute AC joint dislocation. Read More

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Tracking of sport and exercise types from midlife to old age: a 20-year cohort study of British men.

Eur Rev Aging Phys Act 2018 7;15:16. Epub 2018 Dec 7.

1UCL Department of Primary Care & Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF UK.

Background: Previous physical activity (PA) tracking studies have examined the stability of overall PA and/or PA types, but few have investigated how specific types of sport/exercise track over the life course. The aim of this study was to determine how specific sports/exercises in midlife track and predict future sport/exercise and PA in men transitioning to old age.

Methods: Seven thousand seven hundred thirty-five men (aged 40-59 years) recruited in 1978-80 were followed up after 12, 16 and 20 years. Read More

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December 2018

1,8-Bis(dimethylamino)naphthyl-2-ketimines: Inside vs outside protonation.

Beilstein J Org Chem 2018 28;14:2940-2948. Epub 2018 Nov 28.

Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, 198504 St. Petersburg, Russian Federation.

The structure and protonation behaviour of four -arylketimines of 1,8-bis(dimethylamonio)naphthalene with a different number of methoxy groups in an aromatic substituent were investigated in solution by NMR (acetone, DMSO, MeCN), in solid state by X-ray analysis and in the gas phase by DFT calculations. Both mono- and diprotonated species were considered. It has been shown that -isomers of neutral imines can be stabilised by an intramolecular C=N-H···OMe hydrogen bond with a neighbouring methoxy group. Read More

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November 2018

Generation of 1,2-oxathiolium ions from (arysulfonyl)- and (arylsulfinyl)allenes in Brønsted acids. NMR and DFT study of these cations and their reactions.

Beilstein J Org Chem 2018 22;14:2897-2906. Epub 2018 Nov 22.

Department of Organic Chemistry, Institute of Chemistry, Saint Petersburg State University, Universitetskaya nab., 7/9, Saint Petersburg, 199034, Russia.

In strong Brønsted acids (CFSOH, FSOH, DSO), (arysulfonyl)allenes (ArSO-CR=C=CRR) and (arylsulfinyl)allenes (ArSO-CR=C=CRR) undergo cyclization into the corresponding stable 1,2-oxathiolium ions, which were studied by means of NMR and DFT calculations. Quenching of solutions of these cations with low nucleophilic media, aqueous HCl, leads to their deprotonation with a stereoselective formation of (arysulfonyl)butadienes (for instance, ArSO-CR=C-C(Me)=CH, for R = R = Me, yields of 87-98%). Reactions of (arysulfonyl)allenes in the system TfOH (0. Read More

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November 2018

The possible different roles of denosumab in prevention and cure breast cancer bone metastases: A 'hypothesis-generator' study from clinical practice.

Oncol Lett 2018 Dec 10;16(6):7195-7203. Epub 2018 Oct 10.

Medical Oncology, St. Salvatore Hospital, I-67100 L'Aquila, Italy.

The most frequent site of recurrence in breast cancer (BC) is the bone, particularly in patients with 'luminal-like' disease. Denosumab has been shown to prevent aromatase inhibitors (AIs) induced bone resorption in postmenopausal early BC patients and reduce skeletal-related events (SREs) in bone metastatic breast cancer (BMBC). A 'real life' analysis of 90 BMBC patients treated with denosumab was performed. Read More

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December 2018

Morbidity in open versus minimally invasive hybrid esophagectomy (MIOMIE): Long-term results of a randomized controlled clinical study.

Eur Surg 2018 7;50(6):249-255. Epub 2018 Aug 7.

1Department of Surgery, Upper-GI-Service Comprehensive Cancer Center, GET-Unit Medical, University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.

Background: The minimally invasive esophagectomy (MIE) for esophageal cancer was introduced assuming a reduction of morbidity and operation time. After implementation of MIE at our institution, a randomized controlled trial was designed.

Methods: This is a prospective randomized controlled study comparing open (OE) and laparoscopic gastric tube (MIE) formation in Ivor Lewis esophagectomy. Read More

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A Pipeline for Classifying Deleterious Coding Mutations in Agricultural Plants.

Front Plant Sci 2018 28;9:1734. Epub 2018 Nov 28.

Department of Applied Mathematics, Peter the Great St.Petersburg Polytechnic University, St. Petersburg, Russia.

The impact of deleterious variation on both plant fitness and crop productivity is not completely understood and is a hot topic of debates. The deleterious mutations in plants have been solely predicted using sequence conservation methods rather than function-based classifiers due to lack of well-annotated mutational datasets in these organisms. Here, we developed a machine learning classifier based on a dataset of deleterious and neutral mutations in by extracting 18 informative features that discriminate deleterious mutations from neutral, including 9 novel features not used in previous studies. Read More

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November 2018
1 Read

Extreme Geochemical Conditions and Dispersal Limitation Retard Primary Succession of Microbial Communities in Gold Tailings.

Front Microbiol 2018 28;9:2785. Epub 2018 Nov 28.

School of Earth and Environmental Sciences, The University of Queensland, St Lucia, QLD, Australia.

Microbial community succession in tailings materials is poorly understood at present, and likely to be substantially different from similar processes in natural primary successional environments due to the unusual geochemical properties of tailings and the isolated design of tailings storage facilities. This is the first study to evaluate processes of primary succession in microbial communities colonizing unamended tailings, and compare the relative importance of stochastic (predominantly dust-borne dispersal) and deterministic (strong selection pressures from extreme geochemical properties) processes in governing community assembly rates and trajectories to those observed in natural environments. Dispersal-based recruitment required > 6 months to shift microbial community composition in unamended, field-weathered gold tailings; and in the absence of targeted inoculants, recruitment was dominated by salt- and alkali-tolerant species. Read More

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November 2018

Efficacy of First-Line Targeted Therapy in Real-World Korean Patients with Metastatic Renal Cell Carcinoma: Focus on Sunitinib and Pazopanib.

J Korean Med Sci 2018 Dec 22;33(51):e325. Epub 2018 Nov 22.

Department of Urology, National Cancer Center, Goyang, Korea.

Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice.

Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. Read More

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December 2018

A Review of Treatments for Young Black Males Experiencing Depression.

Res Soc Work Pract 2018 Mar 7;28(3):320-329. Epub 2017 May 7.

George Warren Brown School of Social Work, Washington University in St. Louis, St. Louis, MO, USA.

The objective was to qualitatively examine the treatment effects of depression interventions on young, Black males (YBM) across treatment providers and settings via a review. Randomized controlled trials (RCTs) seeking to ameliorate depressive symptomology in Black males ages 12-29 were eligible for inclusion. After review of 627 abstracts and 212 full-text articles, 12 studies were selected. Read More

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Study of stress-induced temporomandibular disorders among dental students: An institutional study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):147-154

Department of Oral Medicine and Radiology, D J College of Dental Sciences and Research, Ghaziabad, Uttar Pradesh, India.

Aim And Objectives: The aim and objectives of this study are to investigate the various types of stress-inducing factors, most prevalent etiological factor and to determine the correlation between stress and temporomandibular disorders (TMDs) in Dental students in Modinagar, Ghaziabad, Uttar Pradesh.

Materials And Methods: A sample of 450 students were selected for the study divided into two groups of undergraduate (UG) and postgraduate (PG) students further subdivided into UG (1, 2, 3, and 4, interns) and PG (1, 2, 3 year). Study includes clinical evaluation of temporomandibular joint (TMJ) system (TMJ sounds, muscles of mastications, mouth opening, and range of mandibular motion) and questionnaire which covers demographic data (i. Read More

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December 2018

Comparative study on alveolar bone healing in postextraction socket versus healing aided with autologous platelet-rich fibrin following surgical removal of bilateral mandibular impacted third molar tooth: A radiographic evaluation.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):140-146

Department of Oral and Maxillofacial Surgery, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamil Nadu, India.

Aim: This study was to evaluate and compare the bone regeneration potential of autologous platelet-rich fibrin (PRF) placed in one of the extracted sockets after the surgical removal of bilateral impacted mandibular third molars.

Patients And Methods: Twenty-five patients (10 females and 15 males; 18-35 years old) were taken for surgical removal of bilateral impacted mandibular third molar, performed in the same session. The autologous PRF was placed in one of the extracted sockets whereas the opposite side was taken as control side, and primary closure was done. Read More

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December 2018

A comparative evaluation of antimicrobial efficacy and flow characteristics of two epoxy resin-based sealers-AH plus and Perma Evolution: An study.

J Conserv Dent 2018 Nov-Dec;21(6):676-680

Department of Conservative Dentistry and Endodontics, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India.

Aim Of The Study: Bacteria that persist at the time of obturation increase the possibility of persistent apical periodontitis. An ideal sealer should be able to kill these remaining bacteria that are present on the dentinal walls as well as inside the dentinal tubules. This could be possible if a sealer has antimicrobial properties with optimum flow characteristics. Read More

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December 2018

Kazin's Trilling: A Cold War Portrait.

Authors:
Richard M Cook

Society 2018 5;55(6):506-511. Epub 2018 Nov 5.

College of Arts and Sciences, Department of English, University of Missouri-St. Louis, 461 Lucas Hall, 1 University Blvd, St. Louis, MO 63121-4400 USA.

This essay describes the eminent Americanist, critic, and New York intellectual, Alfred Kazin's creation of a Lionel Trilling "character" in his 1978 autobiography, , and his use of that character to critique significant features of the country's Cold War literary culture. Among these are: the narrowing and hardening of intellectual discourse in a cultural-political climate dominated by the "liberal consensus," the discrediting of the progressive impulse in American writing, the subordination of "class" to "culture" in evaluations of American writers, and the changing status of Jews and Jewish writers in post-war America. Tapping into strong personal feelings, Kazin creates in Trilling a harsh, thoughtful and compelling portrait of an era. Read More

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November 2018

Exploring the use of adjusted body mass index thresholds based on equivalent insulin resistance for defining overweight and obesity in UK South Asian children.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Population Health Research Institute, St George's, University of London, London, UK.

Background: Body mass index (BMI) overweight/obesity thresholds in South Asian (SA) adults, at equivalent type-2 diabetes risk are lower than for white Europeans (WE). We aimed to define adjusted overweight/obesity thresholds for UK-SA children based on equivalent insulin resistance (HOMA-IR) to WE children.

Methods: In 1138 WE and 1292 SA children aged 9. Read More

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December 2018

Overweight and obesity in preschool aged children and risk of mental health service utilization.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Objective: To determine if overweight or obesity in preschool-age children is associated with mental health service utilization in later childhood.

Subjects: Overall, 10,522 children 2 to <5 years, with no previous history of mental health service utilization, were identified from primary care electronic medical records (EMRs) across Ontario, Canada.

Methods: This was a retrospective longitudinal cohort study. Read More

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December 2018
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A public health framework for the regulation of marketing.

J Public Health Policy 2018 Dec 13. Epub 2018 Dec 13.

Oregon Research Institute, 1776 Millrace, Eugene, OR, 97403, USA.

Cross-sectional, longitudinal, and experimental studies have found a link between youth exposure to cigarette marketing and youth initiation of smoking. These decisive research findings led to regulations of cigarette marketing to youth-including no television or radio ads, prohibitions on the use of cartoons, bans on transit and billboard advertisements, and disallowing tobacco brand sponsorships of sporting events or concerts. Similar products that may cause more harm than benefits include alcohol, electronic cigarettes, and opioids. Read More

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December 2018
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