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Pathol Res Pract 2022 Jun 26;234:153916. Epub 2022 Apr 26.

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Pathology, Veterans Affairs Medical Center, Decatur, GA 30033, USA. Electronic address:

Blue light cystoscopy is utilized to assist Urologists highlight potentially malignant -bladder lesions that might otherwise be undetected by standard cystoscopic techniques. There is a paucity of published studies in the literature regarding the histopathologic findings in this setting, especially regarding false positive lesions. A search was performed for patients who underwent blue light cystoscopy at our institution from 2017 to 2021. Read More

Urol Case Rep 2022 Jul 4;43:102074. Epub 2022 Apr 4.

Department of Urology, Hamad Medical Corporation, Doha, Qatar.

Bladder noninvasive squamous lesions are usually rare; here, we are presenting a case of 39 years old male patient with a benign squamous cell papilloma. The tumor grossly presented as cauliflower mass mimicking squamous cell carcinoma, while histologically, the tumor showed extensive keratinization at its surface and showed no nuclear atypia or stromal invasion. This tumor is benign and extremely rare. Read More

Cureus 2022 Feb 9;14(2):e22046. Epub 2022 Feb 9.

Pathology, Faculty of Medicine, Al-Azhar University, Cairo, EGY.

Urothelial papilloma is a rare benign neoplasm composed of a delicate fibrovascular core covered by normal urothelium. In this report, we present a case of an incidentally detected endovesical papillary growth in ultrasound scan (USS) during a routine check-up, suggestive of bladder tumor which was also suggested by CT urography. The tumor was initially managed with transurethral resection and immediate intravesical instillation of mitomycine C 40 mg. Read More

Andes Pediatr 2021 Oct;92(5):777-780

Departamento de Cirugía Infantil, Hospital Exequiel González Cortes, Santiago, Chile.

Introduction: Inverted urothelial papilloma is a very rare neoplasm in the pediatric population. Because of the low incidence of cases and the reports of atypical components, the management and follow-up plan is not standardized.

Objective: To report a case of inverted papilloma in a female adolescent and to review the diagnostic approach, management, and follow-up plan for this entity. Read More

BMC Urol 2021 Dec 17;21(1):177. Epub 2021 Dec 17.

Department of Urology, Helios University Clinic Wuppertal, Heusnerstrasse 40, 42283, Wuppertal, Germany.

Background: Ichthyosis is a rare skin disorder, in which the shedding of squamous cells is altered. Intravesical ichthyosis is an extremely rare condition. There is evidence for an association with intravesical condylomata accuminata, caused by urogenital infections of the human papilloma virus. Read More

Comput Math Methods Med 2021 16;2021:3781028. Epub 2021 Nov 16.

Department of Urology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, China.

Objective: To study computed tomography (CT) imaging characteristics of bladder tumors, to explore the value of CT in tumor diagnosis, and to identify the relevant factors of CT missed diagnosis so that medical staff can be more accurate in the diagnosis of bladder tumors.

Methods: To retrospectively analyze the CT manifestations of 153 bladder tumor cases confirmed by paraffin pathology in our hospital and to study the difference between the benign and CT imaging features. CT indicators mainly include the number, location, morphology, calcification, bladder wall smoothness, CT value, degree of enhancement, and invasion of surrounding tissues and organs. Read More

Urol Case Rep 2022 Jan 2;40:101926. Epub 2021 Nov 2.

Citrus Memorial Hospital, Inverness, FL, USA.

Inverted urothelial papilloma (IUP) is an unusual tumor that typically presents as a non-invasive, endophytic urothelial neoplasm. Though fairly well described in the bladder, IUP of the upper urinary tract is fairly rare, with only 68 cases documented in English language literature. Our patient presented with an IUP of the distal left ureter and was treated with a distal ureterectomy and reimplant of the ureter with a psoas hitch. Read More

Vet Pathol 2022 01 20;59(1):138-142. Epub 2021 Oct 20.

University of Messina, Messina, Italy.

A 12-year-old neutered female cat was referred with clinical signs referable to lower urinary tract disease. Clinical examination revealed a tense, painful urinary bladder, and proximal urethral thickening. Endoscopic studies showed a pedunculated mass with polypoid projections. Read More

Int J Surg Pathol 2022 May 19;30(3):260-264. Epub 2021 Oct 19.

University of Miami Miller School of Medicine, Miami, FL, USA.

Condyloma acuminatum is a squamous epithelial lesion which uncommonly involves the urinary tract. In this location, non-invasive papillary urothelial carcinoma constitutes one of the main differential diagnoses with significant prognostic and therapeutic implications. To date, no ancillary immunohistochemical stain has been described to differentiate these two entities. Read More

Georgian Med News 2021 Jul-Aug(316-317):178-184

Tbilisi State Medical University, Georgia.

Urothelial carcinoma represents the most common type of bladder cancer (>90%) and is the most frequent malignancy of the urinary tract. Most of the urothelial carcinomas are non-invasive at the time of diagnosis, however they are characterised with the risk of recurrence after surgical treatment. The aim of our study was to investigate the characteristics of tumor heterogeneity and markers of its progression in urothelial papillary carcinomas. Read More

Front Vet Sci 2021 9;8:630089. Epub 2021 Jun 9.

Dipartimento di Medicina Veterinaria e delle Produzioni Animali, Università degli Studi di Napoli Federico II, Naples, Italy.

Blood samples from 260 unrelated cattle (132 animals affected by papillomavirus-associated bladder tumors and 128 healthy) were genotyped using the classic polymerase chain reaction/restriction fragment length polymorphism method to screen MHC class II bovine leukocyte antigen-DRB3. 2 polymorphism. The DRB322 allele was significantly ( ≤ 0. Read More

Clin Nucl Med 2022 Jan;47(1):e11-e13

Department of Pathology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Abstract: A 64-year-old man was referred because of the right ureteral obstruction. CT urography showed an intraluminal enhancing mass in the right midureter and an enhancing nodule in the bladder wall. FDG PET/CT showed increased FDG uptake of the ureteral mass and an unexpected hypermetabolic lesion in the jejunum. Read More

Urol Case Rep 2021 Jul 13;37:101638. Epub 2021 Mar 13.

Department of Surgery, RG KAR Medical College and Hospital, Kolkata, India.

Periurethral lesions are common in post-menopausal women. The differential diagnosis includes urethral caruncle, urethral prolapse, urethral diverticulum and the notorious urethral malignancy. Non-invasive squamous lesion of the urethra is rare with limited data on clinical significance. Read More

Aktuelle Urol 2021 Feb 1;52(1):43-46. Epub 2021 Feb 1.

University Hospital Schleswig-Holstein, Campus Luebeck, Department of Urology, Luebeck.

Intravesical chemotherapy instillation is a unique method of treatment confined to urothelial neoplasia. Within the last decades, the substances Bacillus Calmette-Guerin (BCG) and mitomycin C (MMC) have evolved as the standard regimens for intravesical therapy. However, there are other chemotherapeutic substances, which are used less frequently, such as gemcitabine. Read More

Urol Case Rep 2021 Mar 19;35:101543. Epub 2020 Dec 19.

Department of Urology, Prince Muhammed Bin Nasser Hospital, Jazan, Saudi Arabia.

Bladder cancer is relatively common in the general population but is considered a rare entity in children. Rhabdomyosarcoma is the most frequently encountered bladder tumor in children. Inverted papilloma of the urinary bladder is a rare presentation in adults and is considered extremely rare in the pediatric age group. Read More

J Postgrad Med 2021 Jul-Sep;67(3):182-183

Department of Pathology, Seth G.S. Medical College, Mumbai, Maharashtra, India.

Hum Pathol 2021 03 8;109:53-58. Epub 2020 Dec 8.

Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. Electronic address:

The spectrum of neuroendocrine (NE) tumors in the genitourinary tract ranges from the aggressive large and small cell carcinomas to the often benign paraganglioma and well-differentiated neuroendocrine tumor (WD-NET). At least 15 pure lower urinary tract (LUT) WD-NETs have been described. Owing to the rarity of WD-NET in the LUT and the limited number of reported cases, a better definition of their biologic long-term behavior is warranted. Read More

Hinyokika Kiyo 2020 Nov;66(11):403-406

The Department of Pathology, Seirei Hamamatsu General Hospital.

We report a case of squamous cell papilloma of the urinary bladder, which is an extremely rare disease with only 15 cases reported in the Japanese and English literature. The case was in a 76-year-old woman. She was referred to the department of urology because multifocal tumors of the urinary bladder were found by computed tomographic scan during an examination for acute enteritis. Read More

Infect Agent Cancer 2020 28;15:52. Epub 2020 Aug 28.

Uro-Oncology Research Center, Tehran University of Medical Sciences, Keshavarz Blvd, Tehran, 1419733141 Iran.

Background: Bladder cancer is one of the leading causes of cancer death in adults worldwide. There are various risk factors described for the bladder cancer development including genetic background as well as environmental exposure. Currently, infectious agents such as human papilloma virus (HPV) has also been linked to bladder cancer risk. Read More

Urology 2020 10 16;144:158-163. Epub 2020 Jul 16.

Department of Urology, University of Alabama at Birmingham, Birmingham, AL; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL; O'Neal Comprehensive Cancer Center at UAB, University of Alabama at Birmingham, Birmingham, AL.

Objective: To evaluate the clinical features, pathologic features, and prevalence of human papilloma virus (HPV) in squamous cell carcinoma (SCC) of the bladder. SCC of the bladder is known to be associated with conditions that cause chronic inflammation/irritation. The literature is inconsistent regarding the association of HPV with pure SCC of the bladder. Read More

European J Pediatr Surg Rep 2020 Jan 23;8(1):e23-e26. Epub 2020 Apr 23.

Department of Pediatrics, University of Pecs, Pecs, Hungary.

Urothelial neoplasms of the bladder (UNB) are considerably rare throughout the pediatric population. UNB develops from the urothelial tissue in the form of a benign disease, generally favoring a successful prognosis in the majority of cases. The authors present the diagnosis and treatment regarding two medical case reports in which urothelial papilloma was diagnosed and effectively treated. Read More

Photodiagnosis Photodyn Ther 2020 Jun 18;30:101766. Epub 2020 Apr 18.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Photodynamic diagnosis (PDD) of non-muscle invasive bladder cancer using 5-aminolevulinic acid (5-ALA) has recently attracted attention as a diagnostic method for observing cancer lesions based on fluorescence emission using a fluorescent endoscope. However, there are few reports of false positives associated with benign bladder neoplasms. Here, we provide report of two cases of inverted papillomas of the bladder that were fluorescent on PDD using 5-ALA. Read More

Urol Case Rep 2020 Jul 3;31:101169. Epub 2020 Apr 3.

Medical College of Georgia, USA.

There are three major recognized histological types for primary urethral carcinoma (PUC). These include transitional cell carcinoma (55%), squamous cell carcinoma (21.5%), and adenocarcinoma (16. Read More

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):96-97

Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Inverted papilloma of urothelium is a rare benign tumour accounting for 1-2% of all the urothelial lesions. Morphologically, these are of two main subtypes - trabecular and glandular, of which the former subtype is most frequently encountered compared to the latter. The glandular subtype closely mimics cystitis glandularis and urothelial carcinoma with inverted growth pattern. Read More

J Pathol 2020 04 28;250(4):464-465. Epub 2020 Feb 28.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Aktuelle Urol 2022 06 7;53(3):275-278. Epub 2022 Jun 7.

MVZ OptiPath, Pathologie, Frankfurt am Main.

Background: The occurrence of intravesical condylomata acuminata has been described as a fairly uncommon, benign epithelial lesion. Reports on progression into a muscle-invasive carcinoma of the bladder are rare.

Case: We present the case of a 68-year-old man who had a history of intravesical condylomata acuminata over several years and developed a muscle-invasive squamous cell carcinoma of the bladder. Read More

Hinyokika Kiyo 2019 Nov;65(11):463-467

The Department of Molecular Pathology, Shinshu University School of Medicine.

A 69-year-old male complained of gross hematuria. Cystoscopy revealed a papillary pedunculated tumor. The tumor was approximately 4 cm in length, and mimicked an inverted papilloma with a small stalk and smooth surface, located on the bladder trigone. Read More

Ann Diagn Pathol 2020 Feb 22;44:151433. Epub 2019 Nov 22.

Department of Pathology and Genomic Medicine, The Methodist Hospital and Weill Medical College of Cornell University, Houston, TX 77030, USA. Electronic address:

Background: Most urothelial neoplasms of the bladder show an exophytic papillary pattern, but some show an inverted growth pattern. In 2004, the World Health Organization (WHO) released a detailed histologic classification system for papillary urothelial neoplasms, but not for inverted forms. The International Consultation on Urologic Disease (ICUD) recommendations of 2012 are applicable to inverted/endophytic papillary lesions as follows: 1) inverted papilloma (IP), 2) inverted papillary urothelial neoplasm of low malignant potential (IPUNLMP), 3) inverted papillary urothelial carcinoma, low grade, non-invasive (IPUCLG-NI), 4) inverted papillary urothelial carcinoma, high grade, non-invasive (IPUCHG-NI), 5) inverted papillary urothelial carcinoma, high grade, invasive (IPUCHG-I). Read More

Future Oncol 2019 Nov 18;15(33):3797-3807. Epub 2019 Sep 18.

Department of Urology, Qilu Hospital of Shandong University, Jinan, China.

To evaluate the role of preoperative platelet distribution width (PDW) as a potential biomarker for distinguishing malignancy and tumor advantage of bladder neoplasm. The study included 210 subjects with bladder cancer, 76 subjects with urothelial papilloma and 132 healthy control subjects. Preoperative PDW along with other blood indices was evaluated. Read More

Rapid Commun Mass Spectrom 2020 Apr 8;34 Suppl 1:e8578. Epub 2020 Feb 8.

Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Rationale: Accumulating evidence has linked prolonged exposure to heavy metals to cancer occurrence in the urinary system. However, the specific biological mechanisms responsible for the association of heavy metals with the unusually high incidence of upper tract urothelial carcinoma in Taiwan are complex and incompletely understood.

Methods: To elucidate the specific biological mechanism and identify molecular indicators of the unusually high association of upper tract urothelial carcinoma with heavy metal exposure, protein expression following the treatment of T24 human bladder carcinoma and RT4 human bladder papilloma cell line models with arsenic (As) and cadmium (Cd) was studied. Read More