1,406 results match your criteria Squamous Papilloma of the Urinary Bladder


Benign inverted papilloma at bladder neck causing acute urinary retention.

J Surg Case Rep 2018 Jun 15;2018(6):rjy125. Epub 2018 Jun 15.

Department of Urological Sciences, University of British Columbia, Vancouver, BC, Canada.

Inverted papilloma of the urinary tract is a rare benign lesion. A 59-year-old male who presented with the chief complaint of gross hematuria and acute urinary retention is described. Cystoscopy revealed a solitary, papillary tumor at the bladder neck. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjy12
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http://dx.doi.org/10.1093/jscr/rjy125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007691PMC
June 2018
15 Reads

Pelvic dystopia of right rudimentary multicystic dysplastic kidney as a rare cause of bedwetting in a patient with a single pelvic ectopic left kidney, and agenesis of the uterus and vagina (Mayer-Rokitansky-Küster-Hauser syndrome): a case report.

J Med Case Rep 2018 May 7;12(1):121. Epub 2018 May 7.

AkhmetYassawi International Kazakh-Turkish University, Clinical Diagnostic Center, Turkestan, Kazakhstan.

Background: Pelvic dystopia of rudimentary multicystic dysplastic kidney as a rare cause of bedwetting in children.

Case Presentation: We report the case of a 14-year-old Kazakh girl who presented with difficulty in starting the stream of urine and intermittent interruption of the urinary stream while voiding as well as bedwetting, caused by a rare congenital disease (pelvic dystopia of rudimentary multicystic dysplastic kidney). The diagnostic workup, differential diagnosis, and management, and a review of the literature are presented. Read More

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http://dx.doi.org/10.1186/s13256-018-1644-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937041PMC
May 2018
3 Reads

Urothelial carcinoma in children: A case series.

Bull Cancer 2018 Jun 1;105(6):556-561. Epub 2018 May 1.

Ospedale dei Bambini V. Buzzi, Pediatric Surgery Department, Via Castelvetro 32, 20154 Milano, Italy.

Objective: To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria.

Materials And Methods: After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. Read More

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http://dx.doi.org/10.1016/j.bulcan.2018.03.002DOI Listing
June 2018
6 Reads

Management of Inverted Papilloma During Holmium Laser Enucleation of the Prostate.

Urology 2018 Jun 12;116:e5-e6. Epub 2018 Mar 12.

Department of Urology, University of California, San Francisco, San Francisco, CA.

Inverted papilloma of the prostatic urethra is an especially rare finding. A 75-year-old man with urinary retention wished to proceed with a holmium laser enucleation of the prostate (HoLEP) and was found to have a mass arising from his prostate vs bladder on preoperative imaging. Cystourethroscopy revealed the mass arising from the median lobe of the prostate. Read More

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http://dx.doi.org/10.1016/j.urology.2018.01.009DOI Listing
June 2018
4 Reads

Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.

Ann Diagn Pathol 2017 Dec 17. Epub 2017 Dec 17.

Department of Oncologic Pathology and Prophylactics, Poznan University of Medical Sciences, Department of Oncologic Pathology, Greater Poland Cancer Center, Poland.

Tumours of the urinary tract are the fifth most frequent type of cancer. The most common types are urothelial tumours, among which, non-invasive urothelial neoplasms represent 45% of all cases. The 2016 WHO classification of urinary tract tumours introduced new classifications of non-invasive lesions. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2017.12.007DOI Listing
December 2017
20 Reads

Urothelial neoplasms in pediatric and young adult patients: A large single-center series.

J Pediatr Surg 2018 Feb 14;53(2):306-309. Epub 2017 Nov 14.

Pediatric Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Purpose: Bladder cancer is the sixth most common cancer in the United States, but is exceedingly rare in young patients, leading to a lack of accepted standards for diagnosis, treatment, and surveillance. We review our institutional experience with bladder urothelial neoplasms in pediatric and young adult patients summarizing presentation, treatment, and outcomes.

Methods: Surgical pathology records at our institution were searched for cases of urothelial neoplasms among patients ≤25 years of age treated between January 1997 and September 2016. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828877PMC
February 2018
5 Reads

Biological significance of TERT promoter mutation in papillary urothelial neoplasm of low malignant potential.

Histopathology 2018 Apr 4;72(5):795-803. Epub 2018 Jan 4.

Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.

Aims: Mutations in FGFR3 and the promoter region of the telomerase reverse transcriptase (TERT) gene have been found frequently in urothelial carcinoma of the urinary bladder. However, related data for papillary urothelial neoplasm of low malignant potential (PUNLMP) are limited. In this study, we investigated the mutation status of the TERT promoter, FGFR3 and HRAS in low-grade papillary urothelial neoplasms and evaluated their prognostic significance. Read More

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http://dx.doi.org/10.1111/his.13441DOI Listing
April 2018
15 Reads

Association Between Human Papillomavirus and Transitional Cell Carcinoma of the Bladder.

Urol J 2017 Nov 4;14(6):5047-5050. Epub 2017 Nov 4.

Kermanshah University of Medical Sciences, Kermanshah, Iran.

Purpose: Bladder carcinoma is one of the most common malignancies in worldwide. Among several risk factors, Human Papilloma Virus (HPV) have been presumed to play a causative role in the etiology of bladder cell carcinoma. The aim of this study was to evaluate the involvement of HPV infection in biopsy specimens of patients with transitional cell carcinoma at the west of Iran. Read More

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http://dx.doi.org/10.22037/uj.v14i6.3748DOI Listing
November 2017
4 Reads

Histopathology of Cervical Cancer and Arsenic Concentration in Well Water: An Ecological Analysis.

Int J Environ Res Public Health 2017 10 6;14(10). Epub 2017 Oct 6.

Department of Medicine, University of Alberta, Edmonton T6G 2R3, AB, Canada.

Arsenic in drinking water is causally linked with cancer of the skin, lung, and urinary bladder, but there is very little data on a possible role for arsenic in the etiology of cervical cancer, a disease in which human papilloma virus is held to be a necessary but not sufficient cause. All histopathology results from cervical specimens from the National Institute of Cancer Research and Hospital (NICRH), Dhaka (1997-2015), and the Anowara Medical Services (2003-2015), both serving the whole of Bangladesh, were classified by cell type. Arsenic concentrations in well water in the thana of residence were estimated from systematic sampling carried out by the British Geological Survey. Read More

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http://dx.doi.org/10.3390/ijerph14101185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664686PMC
October 2017
5 Reads

[High oncogenic risk human papillomavirus and urinary bladder cancer].

Urologiia 2017 Jul(3):60-66

Department of Urology and Surgical Andrology RMACPE, Moscow, Russia.

Aim: To determine the role of human papillomavirus (HPV) of high oncogenic risk in the development of urinary bladder cancer.

Materials And Methods: 100 patients (72 men and 28 women) aged 38 to 90 years (mean age 65+/-10 years) diagnosed with bladder cancer were examined and underwent treatment. Clinical assessment was complemented by enzyme-linked immunosorbent assays for the presence of antiviral antibodies to herpes simplex virus (HSV) type 1 and type 2, cytomegalovirus (CMV), Epstein-Barr virus (EBV), urethra scraping for detecting high oncogenic risk HPV. Read More

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July 2017
21 Reads

Conservative treatment of upper urinary tract carcinoma: Long-term results.

Can Urol Assoc J 2017 Jul 11;11(7):E291-E296. Epub 2017 Jul 11.

Department of Urology, Ramón y Cajal University Hospital, Madrid, Spain.

Introduction: We sought to assess the long-term results of conservative treatment for upper urinary tract carcinoma (UUTC) with regard to tumour recurrence and preservation of renal unit.

Methods: From October 1987 to January 2014, 65 patients (median age 68 years) were diagnosed with UUTC and underwent endoscopic and open surgical techniques. Thirteen patients had bilateral disease and one had a single kidney. Read More

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http://www.cuaj.ca/index.php/journal/article/view/4173
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http://dx.doi.org/10.5489/cuaj.4173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519388PMC
July 2017
11 Reads

Evaluation and management of vaginoplasty complications.

Curr Opin Obstet Gynecol 2017 Oct;29(5):316-321

aDepartment of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington bDepartment of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Purpose Of Review: Indications for vaginoplasty include congenital conditions such as adrenal hyperplasia, cloacal malformations, and Müllerian agenesis, acquired conditions including stenosis from radiation or surgical resection for malignancy, and gender affirmation. All vaginoplasty techniques carry significant risk of both immediate and long-term complications.

Recent Findings: The purpose of this study is to provide a review of the evaluation and management of the neovagina, addressing management of human papilloma virus infections and complications including stenosis, fistula, prolapse, and neovaginal colitis. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000391DOI Listing
October 2017
29 Reads

[Inverted papilloma of the bladder: a rare benign tumor: a case report].

Pan Afr Med J 2017;26:204. Epub 2017 Apr 13.

Service d'Urologie, Centre hospitalier de Soissons, Soissons, France.

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http://www.panafrican-med-journal.com/content/article/26/204
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http://dx.doi.org/10.11604/pamj.2017.26.204.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491722PMC
February 2018
9 Reads

Urothelial papilloma: a rare cause of gross haematuria in childhood.

BMJ Case Rep 2017 May 13;2017. Epub 2017 May 13.

Department of Paediatrics, Hospital Center of Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Bladder urothelial papilloma is extremely rare in the paediatric population. It usually presents as painless gross haematuria and its diagnosis implies a high index of suspicion as other causes of haematuria predominate in this age range. We describe a 9-year-old boy with two episodes of gross haematuria occurring 1 year apart with spontaneous resolution after 2 days. Read More

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http://dx.doi.org/10.1136/bcr-2017-219341DOI Listing
May 2017
9 Reads

[Vesical urothelial papilloma].

Cir Pediatr 2016 Jul 10;29(3):131-133. Epub 2016 Jul 10.

Servicio de Cirugía Pediátrica. Hospital Universitario Materno-Infantil. Badajoz.

Introduction: Vesical tumors of infancy are of a low incidence and isolated clinical cases exist, and therefore there are no protocols regarding treatment and monitoring. In addition, the histological criteria used until now are the ones in the WHO 2004 guidelines.

Clinical Case: A 11 year old boy with non-specific abdominal pain. Read More

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July 2016
2 Reads

SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors.

Clin Transl Oncol 2017 Aug 3;19(8):1035-1044. Epub 2017 Mar 3.

Department of Urology, Peking University People's Hospital, The Second Clinical Medical College of Peking University, No. 11, Xi Zhi Men Nan Street, Beijing, 100044, China.

Purpose: To detect the expression level and significance of SOX10 in human bladder cancer.

Methods: Immunohistochemical analyses were performed to assess SOX10 protein level using a bladder cancer tissue microarray (including 59 spots of cancer tissues and 46 spots of paired normal tissues) and 31 specimens and to define the relationship between SOX10 and clinicopathological bladder cancer characteristics in patients. SOX10 protein and mRNA levels in bladder cancer cell lines (T24, 5637, BIU87, EJ) and transitional cell papilloma cell line (RT4) were tested by western blotting and quantitative real-time PCR (q-PCR), respectively. Read More

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http://dx.doi.org/10.1007/s12094-017-1641-2DOI Listing
August 2017
2 Reads

Horseradish extract promotes urinary bladder carcinogenesis when administered to F344 rats in drinking water.

J Appl Toxicol 2017 07 6;37(7):853-862. Epub 2017 Feb 6.

Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-Ku, Tokyo, 158-8501, Japan.

Horseradish extract (HRE), consisting mainly of a mixture of allyl isothiocyanate and other isothiocyanates, has been used as a food additive. To evaluate the potential hazards of HRE, a 104-week chronic study, a 2-week analysis of cell proliferation in the urinary bladder and a medium-term promotion bioassay of HRE were conducted with administration at concentrations of up to 0.04% HRE in the drinking water to male F344 rats. Read More

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http://dx.doi.org/10.1002/jat.3434DOI Listing
July 2017
21 Reads

HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient.

Transpl Infect Dis 2017 Apr 16;19(2). Epub 2017 Mar 16.

Transplantation Unit, Medical Park Hospital, Antalya, Turkey.

Condyloma acuminata (CA) are warty lesions caused by human papilloma virus (HPV) that generally affect the external genitalia and mucocutaneous junctions. Involvement of the urinary tract is rare, and involvement of the urinary bladder is thought to be due to immunosuppression. A 30-year-old woman was diagnosed with urethral CA 12 months after renal transplantation. Read More

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http://doi.wiley.com/10.1111/tid.12667
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http://dx.doi.org/10.1111/tid.12667DOI Listing
April 2017
8 Reads

Condyloma Acuminatum of Urinary Bladder in a Male Renal Transplant Recipient - A Diagnostic and Therapeutic Challenge.

Clin Genitourin Cancer 2017 08 4;15(4):e739-e742. Epub 2017 Jan 4.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2016.12.007DOI Listing
August 2017
11 Reads

TERT Promoter Mutations Occur Frequently in Urothelial Papilloma and Papillary Urothelial Neoplasm of Low Malignant Potential.

Eur Urol 2017 03 28;71(3):497-498. Epub 2016 Dec 28.

Unit of Anatomical Pathology, Faculty of Medicine, Cordoba, Spain; Champalimaud Clinical Center, Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.eururo.2016.12.008DOI Listing
March 2017
6 Reads

Elevated preoperative plasma fibrinogen level is an independent predictor of malignancy and advanced stage disease in patients with bladder urothelial tumors.

Int J Surg 2016 Dec 5;36(Pt A):249-254. Epub 2016 Nov 5.

Department of Urology, Jinshan Hospital of Fudan University, Shanghai City, 201508, PR China. Electronic address:

Purpose: To investigate the association between preoperative plasma fibrinogen levels and clinicopathological features in patients with bladder urothelial tumors.

Methods: In this retrospective single-center study, we evaluated preoperative plasma fibrinogen levels in 503 patients newly diagnosed with bladder urothelial tumors between January 2009 and October 2014. All patients received surgical intervention as the primary treatment method. Read More

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http://dx.doi.org/10.1016/j.ijsu.2016.11.010DOI Listing
December 2016
25 Reads

Squamous cell carcinoma of the urinary bladder: Systematic review of clinical characteristics and therapeutic approaches.

Arab J Urol 2016 Sep 1;14(3):183-91. Epub 2016 Aug 1.

Department of Urology, University of California - Irvine, Orange, CA, USA.

Objective: To highlight the current understanding of the epidemiology, clinicopathological characteristics, and management of squamous cell carcinoma (SCC) of the bladder, as it accounts for 2-5% of bladder tumours, with a focus on non-bilharzial-associated SCC (NB-SCC). The standard treatment for bladder SCC remains radical cystectomy (RC). We present an updated clinical profile of bladder SCC and a review of NB-SCC therapeutic approaches, including RC, neoadjuvant and adjuvant treatments, radiotherapy, chemotherapy, and immunotherapy. Read More

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http://dx.doi.org/10.1016/j.aju.2016.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983161PMC
September 2016
19 Reads

Inverted Papilloma of the Bladder Coexisting with Urothelial Carcinoma. A Case Report.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):52-6

Background: Inverted papilloma (IP) is an unusual benign neoplasm, most commonly found in the bladder. Cases of malignant transformation have been reported in the past, although most of them are now considered to be urothelial carcinomas with an inverted growth pattern.

Case: A 54-year-old man was diagnosed with urothelial carcinoma in situ (UCIS), high-grade papillary urothelial carcinoma (HGPUC), and IP by transurethral resection specimen of the bladder. Read More

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February 2016
25 Reads

Loss of Cell Differentiation in HPV-Associated Bladder Cancer.

Bull Exp Biol Med 2016 May 6;161(1):96-8. Epub 2016 Jun 6.

N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.

Medical histories of 101 urothelial bladder cancer patients were compared with the results of morphological analysis and biomolecular detection of human papilloma viruses (HPV) in the tumor specimens. DNA of HPV16 (the major type of virus responsible for appearance of cervical carcinoma) was detected in 38 specimens, while mRNA of E6 and E7 oncogenes and E7 oncoprotein of HPV16 were observed in 13 specimens. HPV-positive bladder cancer was characterized by higher degree of cell anaplasia than HPV-negative cancer; in the primary bladder tumor, HPV was detected more often than in recurrent bladder cancer. Read More

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http://dx.doi.org/10.1007/s10517-016-3354-xDOI Listing
May 2016
4 Reads

Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.

Int Braz J Urol 2016 Mar-Apr;42(2):242-6

Dicle University, Faculty of Medicine, Department of Medical Pathology, Diyarbakir, Turkey.

Purpose: Bladder tumors are rare in children and adolescents. For this reason, the diagnosis is sometimes delayed in pediatric patients. We aimed to describe the diagnosis, treatment, and follow-up methods of bladder urothelial neoplasms in children and adolescents. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871383PMC
http://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0200DOI Listing
March 2017
10 Reads

Immunohistochemical Differentiation between Urothelial Papillomas and Papillary Neoplasms of Low Malignant Potential of the Urinary Bladder.

Asian Pac J Cancer Prev 2016 ;17(4):1769-72

Department of Pathology, Faculty of Medicine, University of Tanta, Tanta, Egypt E-mail :

Background: Urothelial papilloma and non-invasive papillary carcinoma are common neoplasms of the urinary bladder. Distinguishing papillomas and papillary carcinomas, especially the low grade type, is often debatable on the basis of histological features alone.

Materials And Methods: We investigated immunohistochemical expression of cytokeratin 20 (CK20), p53, and Ki-67 in a group of 20 urothelial papilloma cases and 30 noninvasive papillary neoplasms of low malignant potential (PNLMP) of the urinary bladder. Read More

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January 2017
17 Reads

The pathology of urinary bladder lesions with an inverted growth pattern.

Chin J Cancer Res 2016 Feb;28(1):107-21

1 Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China ; 2 Department of Pathology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Inverted lesions in the urinary bladder have been the source of some difficulty in urological pathology. The two common ones are von Brunn's nests and cystitis cystic/cystitis glandularis, which are considered normal variants of urothelium. Apart from them, a number of other rare urothelial lesions with inverted growth pattern occur in the urinary bladder. Read More

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http://dx.doi.org/10.3978/j.issn.1000-9604.2016.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779755PMC
February 2016
47 Reads

Recurrent TERT promoter mutations in urothelial carcinoma and potential clinical applications.

Ann Diagn Pathol 2016 Apr 17;21:7-11. Epub 2015 Dec 17.

Department of Pathology, Westchester Medical Center/New York Medical College, Valhalla, NY; Department of Pathology, Mount Sinai Medical Center, New York, NY. Electronic address:

Increased telomerase activity is associated with almost all types of advanced human cancers with unknown molecular mechanism(s). Two recurrent point mutations in the promoter region of telomerase reverse transcriptase (TERT)--the key subunit of telomerase--have recently been identified in melanoma as well as a small sample of bladder cancer cell lines. However, the incidence and clinical-pathological significance of these mutations in urothelial carcinoma have not been well established yet. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134150015
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http://dx.doi.org/10.1016/j.anndiagpath.2015.12.002DOI Listing
April 2016
21 Reads

[NARROWED SPECTRUM DIAGNOSTICS AND COMPUTER CHROMOENDOSCOPY IN THE DIAGNOSIS OF EPITHELIAL NEOPLASMS OF THE LOWER AND UPPER URINARY TRACT].

Urologiia 2015 Sep-Oct(5):55-9

Unlabelled: Tumors of epithelial origin occupy the first place in the structure of oncological diseases. This study was aimed to the evaluation of the possibilities of narrowed spectrum endoscopy and computer chromoendoscopy in the diagnosis of epithelial structures of the bladder and upper urinary tract.

Materials And Methods: Additional diagnostic endoscopic examination of the lower urinary tract was performed in 76 patients (132 urethrocystoscopies). Read More

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February 2016
4 Reads

Telomerase reverse transcriptase (TERT) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of inverted papilloma with immortalizing genetic change.

Histopathology 2016 Jul 11;69(1):107-13. Epub 2016 Feb 11.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Aims: To understand more clearly the genetic ontogeny of inverted papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases).

Methods And Results: TERT promoter mutations in inverted papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. Read More

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http://dx.doi.org/10.1111/his.12920DOI Listing
July 2016
39 Reads

Altered expression of CKs 14/20 is an early event in a rat model of multistep bladder carcinogenesis.

Int J Exp Pathol 2015 Oct 30;96(5):319-25. Epub 2015 Oct 30.

Grupo de Patologia e Terapêutica Experimental, CI-IPOP, Instituto Português de Oncologia, Porto, Portugal.

Cytokeratins (CKs) 14 and 20 are promising markers for diagnosing urothelial lesions and for studying their prognosis and histogenesis. This work aimed to study the immunohistochemical staining patterns of CK14/20 during multistep carcinogenesis leading to papillary bladder cancer in a rat model. Thirty female Fischer 344 rats were divided into three groups: group 1 (control); group 2, which received N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 20 weeks plus 1 week without treatment; and group 3, which received BBN for 20 weeks plus 8 weeks without treatment. Read More

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http://dx.doi.org/10.1111/iep.12145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693561PMC
October 2015
10 Reads

An interesting finding in the uterine cervix: Schistosoma hematobium calcified eggs.

Autops Case Rep 2015 Apr-Jun;5(2):41-4. Epub 2015 Jun 30.

Gynecology Department - Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo/SP - Brazil .

Schistosoma hematobium infection is an endemic parasitic disease in Africa, which is frequently associated with urinary schistosomiasis. The parasite infection causes epithelial changes and disruption, facilitating the infection by the human papilloma virus and human immunodeficiency virus (HIV). The authors report the case of a 44-year-old African HIV-positive woman who presented an abnormal routine Pap smear. Read More

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http://dx.doi.org/10.4322/acr.2015.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584668PMC
October 2015
8 Reads

Transurethral Resection of the Bladder Tumour as a Treatment Method in Children with Transitional Cell Carcinoma of the Bladder--Analysis of Our Material and Literature Review.

Adv Clin Exp Med 2015 May-Jun;24(3):505-9

Department of Palliative Care Nursing, Wroclaw Medical University, Poland; Department of Urology, 4th Military Clinical Hospital with Polyclinic, Wrocław, Poland.

Background: Bladder cancer occurs mainly in adults. In children, younger than 10 years in particular, it is very rare.

Objectives: The aim of the study is to retrospectively evaluate the efficacy of transurethral resection of the bladder tumour (TUR-BT) of transitional cell carcinoma (TCC) of the bladder in children. Read More

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http://dx.doi.org/10.17219/acem/36600DOI Listing
November 2015
19 Reads

A clinical and molecular review of inverted papilloma of the urinary tract: how to handle?

APMIS 2015 Nov 11;123(11):920-9. Epub 2015 Sep 11.

Department of Urology, Bispebjerg and Frederiksberg Hospitals, University of Copenhagen, Copenhagen, Denmark.

Inverted papilloma (IP) of the urinary tract is classified by the World Health Organisation as a non-invasive urothelial tumour with normal to minimal cytological atypia of the neoplastic cells. During the 1980s, it came under suspicion of having a premalignant or malignant potential and of being concurrent with urothelial cell carcinoma (UCC). This quandary has been proven difficult to solve, due to the fact that IP is very rare and literature mostly consists of case reports with varying levels of information, making strong meta-analyses problematic. Read More

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http://doi.wiley.com/10.1111/apm.12456
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http://dx.doi.org/10.1111/apm.12456DOI Listing
November 2015
33 Reads

Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats.

Vet Pathol 2016 May 28;53(3):682-90. Epub 2015 Aug 28.

Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA

o-Nitroanisole is an intermediate in the manufacture of azo dyes. In a National Toxicology Program stop-exposure study,o-nitroanisole induced hyperplasia, papillomas, and papillary carcinomas in the urinary bladder of Fischer 344/N rats.o-Nitroanisole was investigated since occupational or environmental exposure to aniline and azo dyes is a risk factor for urinary bladder cancer in humans. Read More

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http://journals.sagepub.com/doi/10.1177/0300985815603432
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http://dx.doi.org/10.1177/0300985815603432DOI Listing
May 2016
10 Reads

Inverted urothelial carcinoma: a series of 12 cases with a wide morphologic spectrum overlapping with the large nested variant.

Hum Pathol 2015 Oct 26;46(10):1506-13. Epub 2015 Jun 26.

Department of Pathology, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec H4J1C5, Canada.

The current series presents 12 cases of invasive urothelial carcinoma (UC) with inverted growth pattern that fulfill the architectural criteria of the recently described "large nested" variant of UC, but which display a wider spectrum of morphologic and cytologic changes. All cases had an associated component of usual invasive UC, and 10 had an associated surface papillary component. Although many areas within the tumors were indistinguishable from a noninvasive endophytic growth pattern, at least some had an irregular ragged contour, and all showed haphazard arrangement with variable amount of intervening stroma at least focally. Read More

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http://dx.doi.org/10.1016/j.humpath.2015.06.010DOI Listing
October 2015
12 Reads

Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion, and tumorigenesis in bladder carcinoma cells.

Sci Rep 2015 Aug 7;5:12870. Epub 2015 Aug 7.

Department of Anatomy, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, ROC.

Growth differentiation factor-15 (GDF15), a member of the TGF-β superfamily, affects tumor biology of certain cancers, but remains poorly understood in bladder cancer cells. This study determined the expression, regulation, function, and potential downstream target genes of GDF15 in bladder carcinoma cells. The transitional papilloma carcionoma cells (RT4) expressed higher levels of GDF15 as compared with the bladder carcinoma cells (HT1376 and T24). Read More

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http://dx.doi.org/10.1038/srep12870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528199PMC
August 2015
6 Reads

MRI Findings of Inverted Urothelial Papilloma of the Bladder.

AJR Am J Roentgenol 2015 Aug;205(2):311-6

1 Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical School, 1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.

Objective: The objective of this study was to characterize MRI findings of inverted urothelial papilloma of the bladder.

Materials And Methods: Data pertaining to 16 patients with 18 pathologically proven inverted urothelial papillomas of the bladder who had undergone MRI were retrospectively collected from seven institutions. The shape and surface characteristics of the tumors were evaluated using T2-weighted MR images. Read More

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http://dx.doi.org/10.2214/AJR.14.13879DOI Listing
August 2015
21 Reads

EFFICACY OF DIFFERENT RESECTIONS ON NON-MUSCLE-INVASIVE BLADDER CANCER AND ANALYSIS OF THE OPTIMAL SURGICAL METHOD.

J Biol Regul Homeost Agents 2015 Apr-Jun;29(2):465-70

Department of Urology, the General Hospital of the Chinese People’s Liberation Army, Haidian, Beijing, China.

This study aimed to analyze the clinical efficacy of different resections in treating non-muscle-invasive bladder cancer (NMIBC), including partial cystectomy, transurethral resection of bladder tumor (TURBT) and holmium laser resection of bladder tumor. Two hundred and sixteen patients were recruited with NMIBC who were available for follow-up visits in hospital, including 62 cases treated with partial cystectomy, 90 cases treated with TURBT and 64 cases with holmium laser resection. Analysis was made on the cases with tumor relapse in the two years, on operation time, blood loss, time for indwelling urinary catheter, hospital stay and complications after operation. Read More

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August 2015
8 Reads

Detection and quantification of bovine papillomavirus type 2 in urinary bladders and lymph nodes in cases of Bovine Enzootic Hematuria from the endemic region of Azores.

Vet Microbiol 2015 Jul 16;178(1-2):138-43. Epub 2015 Apr 16.

Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA), Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.

Bovine Enzootic Hematuria (BEH) is a disease with a severe impact on production indexes and characterized by the development of bovine urinary bladder tumors, particularly in the Azores archipelago. The purpose of this study was to investigate and quantify BPV2 tissue distribution in bovine urinary bladder tumors, normal bladders, and iliac lymph nodes of cattle from the Azores. A real-time PCR system targeting the L1 gene was developed and allowed for the specific detection of the virus. Read More

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http://dx.doi.org/10.1016/j.vetmic.2015.03.026DOI Listing
July 2015
8 Reads

Cantharidin Induces Apoptosis Through the Calcium/PKC-Regulated Endoplasmic Reticulum Stress Pathway in Human Bladder Cancer Cells.

Am J Chin Med 2015 ;43(3):581-600

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan , Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua County, Taiwan.

Bladder cancer is a common malignancy worldwide. However, there is still no effective therapy for bladder cancer. In this study, we investigated the cytotoxic effects of cantharidin [a natural toxin produced (pure compound) from Chinese blister beetles (Mylabrisphalerata or Mylabriscichorii) and Spanish flies (Cantharis vesicatoria)] in human bladder cancer cell lines (including: T24 and RT4 cells). Read More

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http://dx.doi.org/10.1142/S0192415X15500366DOI Listing
February 2016
56 Reads

Long-term outcome of primary Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) including PUNLMP with inverted growth.

Diagn Pathol 2015 Mar 13;10. Epub 2015 Mar 13.

Department of Pathology and Laboratory Medicine, Calgary Laboratory Service and University of Calgary, Rockyview General Hospital, 7007 14 Street, Calgary, AB, Canada.

Background: Few larger studies have evaluated the long-term outcome after a diagnosis of papillary urothelial neoplasm of low malignant potential (PUNLMP), demonstrating a broad range of recurrence and progression rates. Additionally, no study has addressed the outcome of PUNLMP exhibiting inverted growth. We evaluated the long term clinical outcome of primary papillary urothelial neoplasm of low malignant potential (PUNLMP), including PUNLMP with inverted growth in a large single center study. Read More

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http://dx.doi.org/10.1186/s13000-015-0234-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415259PMC
March 2015
35 Reads
4 Citations
2.411 Impact Factor

OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.

Epigenetics 2014 Dec;9(12):1626-40

a Molecular Oncology Group; Institute of Pathology ; RWTH Aachen University ; Aachen , Germany.

CREB3L1 has been recently proposed as a novel metastasis suppressor gene in breast cancer. Our current study highlights CREB3L1 expression, regulation, and function in bladder cancer. We demonstrate a significant downregulation of CREB3L1 mRNA expression (n = 64) in primary bladder cancer tissues caused by tumor-specific CREB3L1 promoter hypermethylation (n = 51). Read More

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http://dx.doi.org/10.4161/15592294.2014.988052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623247PMC
December 2014
12 Reads

Urinary bladder xanthoma: a multi-institutional series of 17 cases.

Histopathology 2015 Aug 19;67(2):255-61. Epub 2015 Feb 19.

Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada.

Aims: To present a series of urinary bladder xanthomas and characterize their clinical features and associated pathology.

Methods And Results: We retrieved the clinicopathological data of bladder xanthomas, with and without associated urothelial neoplasms. We identified six isolated bladder xanthomas and 11 arising within or adjacent to urothelial neoplasms. Read More

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http://dx.doi.org/10.1111/his.12647DOI Listing
August 2015
21 Reads
1 Citation
3.453 Impact Factor

Bladder urothelial neoplasms in pediatric age: experience at three tertiary centers.

J Pediatr Urol 2015 Feb 28;11(1):26.e1-5. Epub 2014 Sep 28.

Department Nephrology-Urology, Division of Pediatric Urology, 'Bambino Gesù' Children's Hospital Rome, IRCCS, Piazza S. Onofrio, 4, 00165 Roma, Italy. Electronic address:

Introduction: Urothelial bladder neoplasms (UBN) typically occur in patients in their sixth or seventh decade of life while they are infrequent in children and young adults. They occur in 0.1-0. Read More

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http://dx.doi.org/10.1016/j.jpurol.2014.08.008DOI Listing
February 2015
27 Reads

Targeting of alpha-v integrins reduces malignancy of bladder carcinoma.

PLoS One 2014 23;9(9):e108464. Epub 2014 Sep 23.

Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands.

Low survival rates of metastatic cancers emphasize the need for a drug that can prevent and/or treat metastatic cancer. αv integrins are involved in essential processes for tumor growth and metastasis and targeting of αv integrins has been shown to decrease angiogenesis, tumor growth and metastasis. In this study, the role of αv integrin and its potential as a drug target in bladder cancer was investigated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108464PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172769PMC
January 2016
6 Reads

Nested and microcystic variants of urothelial carcinoma displaying immunohistochemical features of basal-like urothelial cells: an immunohistochemical and histopathogenetic study.

Pathol Int 2014 Aug;64(8):375-81

Pathology and Laboratory Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

Nested/microcystic (NV/MV) urothelial carcinoma (UC) variants are associated with mild cytologic atypia and commonly present at high-stage disease. The histopathogenesis is investigated using urothelial basal cell markers. Archival 14 NV/MV and three inverted papilloma (IP) were immunostained for CD44, cytokeratin 5 (CK5), CK34bE12 and p63. Read More

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http://dx.doi.org/10.1111/pin.12187DOI Listing
August 2014
15 Reads

Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases.

Am J Surg Pathol 2014 Nov;38(11):1516-21

*The Department of Pathology ‡Urology and Oncology, The Johns Hopkins Hospital, Baltimore, MD †Department of Pathology, Queen Elizabeth Hospital, Hong Kong, PR China.

Metastatic renal cell carcinoma (RCC) to the urinary bladder is rarely seen. Herein, we report the histologic subtypes, immunohistochemical characteristics, and prognosis of 11 patients with metastatic RCC to the urinary bladder. The mean age at the time of diagnosis of metastatic RCC to the bladder was 66 years (range, 58 to 79 y). Read More

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http://dx.doi.org/10.1097/PAS.0000000000000257DOI Listing
November 2014
7 Reads

HRAS mutations are frequent in inverted urothelial neoplasms.

Hum Pathol 2014 Sep 18;45(9):1957-65. Epub 2014 Jun 18.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations present in IUP or other urothelial neoplasms, which might demonstrate inverted growth pattern like low-grade or high-grade urothelial carcinoma (UCA). Read More

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http://dx.doi.org/10.1016/j.humpath.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241848PMC
September 2014
16 Reads