2,929 results match your criteria Squamous Cell Carcinoma of the Urinary Bladder

Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma.

Urol Oncol 2021 May 31. Epub 2021 May 31.

Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.

Objective: Carbonic anhydrase IX (CA9) is important in the regulation of intra- and extracellular pH in solid tumors, contributing to cell growth and invasion. In urothelial carcinoma (UC), CA9 has been identified as a urinary marker for disease detection, but its biologic role is unknown. To date, differential gene expression patterns of CA9 in various molecular subtypes and potential effects of CA9 inhibition in UC cells are unknown. Read More

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[A Case of Bladder Squamous Cell Carcinoma with Neurogenic Bladder Caused by Myelomeningocele].

Hinyokika Kiyo 2021 Mar;67(3):103-107

The Department of Urology, enpan Community Health-Care Organization Hoshigaoka Medical Center.

A 38-year-old woman with neurogenic bladder caused by myelomeningocele,who had been on clean intermittent self-catheterization for years,complained of gross hematuria. Computerized tomography, urinary cytology and cystoscopy failed to reveal causative lesions and the hematuria ceased spontaneously. Because gross hematuria recurred 2 years later,we examined the patient again and detected calcification of the urinary bladder. Read More

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Primary squamous cell carcinoma of the urinary bladder presenting as an inguinal mass.

SA J Radiol 2021 29;25(1):2048. Epub 2021 Mar 29.

Department of Radiology, St. Vincent's Medical Center, Bridgeport, CT, The United States of America.

This report involves a rare case of a 74-year-old man who presented with a progressively increasing swelling in the right groin, which represented a squamous cell bladder carcinoma herniating into the right inguinal canal. The manuscript discusses the role of multimodality imaging in bladder carcinoma presenting as an inguinoscrotal hernia. The patient subsequently underwent treatment with a chemotherapy regimen consisting of 5-fluorouracil and mitomycin, which was extrapolated from squamous cell carcinoma of the anal canal, and responded well. Read More

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Urinary bladder cancer as a late sequela of traumatic spinal cord injury.

Mil Med Res 2021 04 29;8(1):29. Epub 2021 Apr 29.

Clinical Occupational Medicine, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), 44139, Dortmund, Germany.

Background: Traumatic spinal cord injury (SCI) is also a combat-related injury that is increasing in modern warfare. The aim of this work is to inform medical experts regarding the different course of bladder cancer in able-bodied patients compared with SCI patients based on the latest medical scientific knowledge, and to present decision-making aids for the assessment of bladder cancer as a late sequela of traumatic SCI.

Methods: A study conducted between January 1998 and December 2019 in the BG Trauma Hospital Hamburg formed the basis for the decision-making aids. Read More

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Combined use of immunohistochemical markers of basal and luminal subtypes in urothelial carcinoma of the bladder: Association with clinicopathological features and outcomes.

Clinics (Sao Paulo) 2021 26;76:e2587. Epub 2021 Apr 26.

Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Whole genome expression profiles allow the stratification of bladder urothelial carcinoma into basal and luminal subtypes which differ in histological patterns and clinical behavior. Morpho-molecular studies have resulted in the discovery of immunohistochemical markers that might enable discrimination between these two major phenotypes of urothelial carcinoma.

Methods: We used two combinations of immunohistochemical markers, i. Read More

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Sarcomatoid Urothelial Carcinoma With Myxoid Stroma: A Case Report and Diagnostic Approach.

Cureus 2021 Mar 20;13(3):e14007. Epub 2021 Mar 20.

Pathology, Obeid Specialized Hospital, Riyadh, SAU.

Bladder cancer is the seventh most common cancer in the world. Urothelial carcinoma is the most common type of bladder cancer. Other subtypes like squamous cell carcinoma and adenocarcinoma are less common. Read More

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J Zoo Wildl Med 2021 Apr;52(1):145-156

Wildlife Conservation Society, Zoological Health Program, Bronx Zoo, Bronx, NY 10460, USA,

The objective of this 20-yr retrospective study was to review and summarize causes of mortality in the North American (NA) snow leopard population to inform and enhance animal health and husbandry practices. Pathology reports were requested from all NA zoological institutions housing snow leopards that died between 01 January 1999 and 31 December 2019. Data were reviewed and cause of death (COD) and concurrent diseases were summarized and compared by age group, organ system, and disease process. Read More

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Schistosomiasis Morbidity Hotspots: Roles of the Human Host, the Parasite and Their Interface in the Development of Severe Morbidity.

Front Immunol 2021 12;12:635869. Epub 2021 Mar 12.

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

Schistosomiasis is the second most important human parasitic disease in terms of socioeconomic impact, causing great morbidity and mortality, predominantly across the African continent. For intestinal schistosomiasis, severe morbidity manifests as periportal fibrosis (PPF) in which large tracts of macro-fibrosis of the liver, visible by ultrasound, can occlude the main portal vein leading to portal hypertension (PHT), sequelae such as ascites and collateral vasculature, and ultimately fatalities. For urogenital schistosomiasis, severe morbidity manifests as pathology throughout the urinary system and genitals, and is a definitive cause of squamous cell bladder carcinoma. Read More

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Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.

Oncology 2021 18;99(6):345-358. Epub 2021 Mar 18.

Urology Unit, University of Foggia, Bonomo Teaching Hospital, Foggia, Italy.

Background: The most common bladder cancer (BC) histotype is pure urothelial carcinoma (UC), which may undergo divergent differentiation in some cases. Variant histology (VH) presents along variable morphologies, either single or combined between them or with pure UC. From a clinical standpoint, the vast majority of BC is diagnosed at non-invasive or minimally invasive stages, namely as non-muscle invasive BC (NMIBC). Read More

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Large distal ureteric stone with high burden urothelial cancer of the entire ureter and renal pelvis: a dual pathology.

Ann R Coll Surg Engl 2021 Apr 5;103(4):e136-e139. Epub 2021 Mar 5.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Upper-tract urothelial cancer comprises only 3% of all urothelial cancers. Risk factors include tobacco smoking, recurrent urinary infection, urolithiasis and analgesic abuse. Urolithiasis-induced chronic inflammation leads to urothelial proliferation and eventual malignant transformation. Read More

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Prospective assessment of urinary and bowel symptoms, and sexual function between laparoscopic assisted vaginal radical trachelectomy and radical hysterectomy.

Int J Gynecol Cancer 2021 Mar;31(3):484-489

Department of Gynecology, Asklepios Clinic Lich, Hessen, Germany.

Objective: Radical trachelectomy is a valid alternative to radical hysterectomy in women with a desire to retain their fertility. Data regarding the oncological outcomes of radical trachelectomy are comparable with those of radical hysterectomy but information regarding urinary and sexual function is limited. The aim of this study was to prospectively evaluate and compare quality of life, urinary and bowel symptoms, and sexual dysfunction between patients who underwent laparoscopic assisted vaginal radical trachelectomy versus radical hysterectomy for early-stage cervical cancer. Read More

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Results of image guided brachytherapy for stage IB cervical cancer in the RetroEMBRACE study.

Radiother Oncol 2021 04 19;157:24-31. Epub 2021 Jan 19.

Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.

Objective: Multiple treatment options are used in early local-stage cervical cancer, including combinations of surgery with neoadjuvant/adjuvant radiotherapy and chemotherapy. Our aim was to determine the outcome for definitive chemoradiation with image guided brachytherapy (IGBT).

Methods: FIGO staging system was used in our study. Read More

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Urogenital Schistosomiasis-History, Pathogenesis, and Bladder Cancer.

J Clin Med 2021 Jan 8;10(2). Epub 2021 Jan 8.

Center for the Study in Animal Science (CECA/ICETA), University of Porto, Rua de D. Manuel II, Apt 55142, 4051-401 Porto, Portugal.

Schistosomiasis is the most important helminthiasis worldwide in terms of morbidity and mortality. Most of the infections occurs in Africa, which about two thirds are caused by . The infection with is considered carcinogenic leading to squamous cell carcinoma (SCC) and urothelial carcinoma of the urinary bladder. Read More

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January 2021

[Squamous cell carcinoma of the bladder: a retrospective study conducted in a Moroccan University Hospital and literature review].

Pan Afr Med J 2020 8;37:143. Epub 2020 Oct 8.

Service d'Urologie A, CHU Ibn Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Maroc.

Squamous cell carcinoma of the bladder is a rare form of bladder tumor, accounting for less than 5% of bladder cancers. Sex ratio is balanced and the black population is more affected by this disease. It manifests with non-specific clinical symptoms and it is dominated by haematuria. Read More

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January 2021

Identification of a novel immune microenvironment signature predicting survival and therapeutic options for bladder cancer.

Aging (Albany NY) 2020 12 19;13(2):2780-2802. Epub 2020 Dec 19.

Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.

Few studies have investigated the potential of tumor immune microenvironment genes as indicators of urinary bladder cancer. Here, we sought to establish an immune-related gene signature for determining prognosis and treatment options. We developed a ten-gene tumor immune microenvironment signature and evaluated its prognostic capacity on internal and external cohorts. Read More

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December 2020

Bladder squamous cell carcinoma in a pregnant woman: case report and review of the literature.

BMC Urol 2021 Jan 6;21(1). Epub 2021 Jan 6.

Departamento de Urología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile.

Background: Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described.

Case Presentation: We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. Read More

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January 2021

Prostate squamous cell carcinoma developing 11 years after external radiotherapy for prostate adenocarcinoma.

IJU Case Rep 2020 Jul 20;3(4):121-124. Epub 2020 Apr 20.

Department of Urology Kyoto Prefectural University of Medicine Kyoto Japan.

Introduction: Secondary bladder, colon, and rectal cancers are relatively common after prostate radiotherapy. However, secondary squamous cell carcinoma of the prostate is rare.

Case Presentation: An 85-year-old man presented with dysuria and low-serum prostate-specific antigen levels. Read More

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Five-Year Survival Rate of Bladder Cancer in Iran during 2001-2007.

Iran J Pathol 2021 10;16(1):69-74. Epub 2020 Oct 10.

Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background & Objective: Bladder cancer is the fourth most common cancer in men and the most common cancer in women, comprising 8% of all males and 3% of female tumors. The present study aimed to estimate the five-year survival rates of bladder cancer in Iran.

Methods: Information on 3,337 registered cases of bladder cancer was obtained from the Office of National Cancer Registry in the Ministry of Health and Medical Education (MOH & ME). Read More

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October 2020

PD-L1 Expression in Muscle-Invasive Urinary Bladder Urothelial Carcinoma According to Basal/Squamous-Like Phenotype.

Front Oncol 2020 7;10:527385. Epub 2020 Dec 7.

Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.

Urothelial carcinoma (UC) is the most common histologic type of urinary bladder cancer, and muscle-invasive UC shows aggressive behaviors. Programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) blockades have been approved as standard treatments for patients with advanced stage UC. A total of 166 muscle-invasive urinary bladder cancer (MIBC) patients, who underwent transurethral resection of the bladder or cystectomy from 2004 to 2010 were included. Read More

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December 2020

An interesting presentation of invasive bladder carcinoma as pseudo renal failure.

J Bras Nefrol 2020 Dec 18. Epub 2020 Dec 18.

Sri Sathya Sai Institute of Higher Medical Sciences, Department of Urology, Prashantigram, Puttaparthi, Andhra Pradesh 515134, India.

Ascites and oliguria with an increasing serum creatinine level are often observed in patients with acute renal failure. However, these symptoms are also noted in individuals with intraperitoneal urinary leakage and can be mistaken for acute renal failure. This rise in creatinine in such patients is called pseudo renal failure and it happens by a process of reverse peritoneal dialysis. Read More

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December 2020

Diagnostic value of urine cytology in detecting histologic variants of urothelial carcinomas in the urinary bladder: Cytopathologic correlation of 72 cases.

Diagn Cytopathol 2021 Mar 16;49(3):367-373. Epub 2020 Dec 16.

Department of Pathology, Ewha Womans University College of Medicine, Seoul, South Korea.

Background: Precise identification of histologic variants in urothelial carcinoma (UC) is important because some histologic types have a poor prognosis and clinical management varies. Urine cytology is used for bladder cancer screening, but the cytomorphologic features of histologic variants have not been well described. In the current study, we evaluate the effectiveness of urine cytology in detecting histologic variants of UC in the urinary bladder. Read More

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Chloride Intracellular Channel Protein 1 (CLIC1) Ιs Over-expressed in Muscle Invasive Urinary Bladder Cancer.

Anticancer Res 2020 Dec;40(12):6879-6884

Department of Microscopic Morphology/Histology, Angiogenesis Research Center Timisoara, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania

Background/aim: Invasive bladder cancer mortality remains high despite progresses made in early diagnosis and surgical procedures. Thus, there is a need to define new markers for bladder cancer. CLIC1 has not been previously studied in bladder cancer and thus, we aimed to assess its immunohistochemical expression in relation to different stages of bladder cancer development. Read More

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December 2020

Urinary schistosomiasis and the associated bladder cancer: update.

J Egypt Natl Canc Inst 2020 Nov 30;32(1):44. Epub 2020 Nov 30.

Department of Radiation Oncology, Washington University in St. Louis, St. Louis, USA.

Background: Urinary schistosomiasis and its severe complications, mainly bladder cancer, are scarce in non-endemic areas. The deficiency in knowledge and clinical experience of schistosomiasis may lead to inadequate management. Highlighting these topics may be of value, especially with the increased immigration from endemic low-/middle-income countries (LMIC) to non-endemic high-income countries (HIC). Read More

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November 2020

Stratification of urinary bladder carcinoma based on immunohistochemical expression of CK5, CK14 and CK20.

J Immunoassay Immunochem 2021 May 19;42(3):236-251. Epub 2020 Nov 19.

Pathology Department, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt.

Molecular subtyping of urothelial carcinoma (UC) is similar to that of breast cancer and is based on the developmental biology approach. The aim of the present study is to assess the prognostic impact of CK5, CK14, and CK20 expression in urinary bladder cancer (UBC) with the potential to stratify them into different subtypes. The current study examined the immunohistochemical expression of CK5, CK14, and CK20 in 90 specimens of UBC. Read More

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The discovery of bacterial biofilm in patients with muscle invasive bladder cancer.

APMIS 2021 May 26;129(5):265-270. Epub 2021 Feb 26.

Department of Urology, Zealand University Hospital, Roskilde, Denmark.

The carcinogenic effects of microorganisms have been discovered in multiple cancer types. In urology, the development of squamous cell carcinoma of the bladder due to the parasitic infection with Schistosoma Mansoni is widely accepted. The oncogenic potential of biofilms has been studied in colorectal cancer and experimental studies have shown that bacteria such as Escherichia coli drive the development of colorectal cancer. Read More

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Nested Variant of Urothelial Carcinoma Is a Luminal Bladder Tumor With Distinct Coexpression of the Basal Marker Cytokeratin 5/6.

Am J Clin Pathol 2021 03;155(4):588-596

Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill.

Objectives: The nested variant of urothelial carcinoma (NVUC) is a rare bladder tumor that may possess a luminal molecular phenotype. We sought to determine whether a small immunohistochemical (IHC) panel using common surrogates for molecular phenotypes would reliably classify a cohort of pure NVUC cases.

Methods: IHC staining with a panel composed of markers for basal subtypes (CK5/6, CK14) and luminal subtypes (FOXA1, GATA3) was performed on pure small NVUC cases (n = 23) and 5 large NVUC cases (n = 5). Read More

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Tumour-like lesions of the urinary bladder.

Pathology 2021 Jan 15;53(1):44-55. Epub 2020 Oct 15.

Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

There are a number of benign epithelial proliferations in the bladder that may be difficult to distinguish from carcinomas, including urothelial carcinoma and its variants, squamous cell carcinoma and adenocarcinoma. If misdiagnosed, there is the potential for over treatment, with its attendant risk of complications, as well as errors relating to prognostic assessment. In the case of the misdiagnosis of high grade proliferative lesions that mimic invasive carcinoma, unnecessary radical surgery, chemotherapy and radiotherapy may result. Read More

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January 2021

Increased PD-L1 expression in high-grade bladder cancer with squamous cell differentiation in Bulgarian and French patients' samples.

Ann Diagn Pathol 2020 Dec 8;49:151640. Epub 2020 Oct 8.

Department of General and Clinical Pathology, Medical University/University Hospital "St.George", Plovdiv, Bulgaria.

Urothelial carcinomas (UC) of the bladder are biologically and clinically heterogeneous and the most common malignancy of the urinary tract in developed countries worldwide, where several checkpoint targets as programmed death ligand-1 (PD-L1) and programmed cell death protein (PD-1) have received the most attention in the treatment of bladder cancer. However, the clinicopathological impact of this biomarker has not yet been established enough.

Objective: To evaluate programmed death ligand-1 (PD-L1) expression in UCs of the bladder in Bulgarian and French patients' samples. Read More

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December 2020

Morphological correlation of urinary bladder cancer molecular subtypes in radical cystectomies.

Hum Pathol 2020 12 26;106:54-61. Epub 2020 Sep 26.

Department of Pathology, University of Chicago, Chicago, IL, USA; Department of Surgery (Urology), University of Chicago, Chicago, IL, USA. Electronic address:

Several molecular subtypes of bladder cancer were identified with differing clinical behavior and responses to platinum-based chemotherapy. But so far, their urothelial histomorphologic features, besides association with some variant histologies, have remained fully undefined. We sought to characterize the histological features of genomically classified bladder cancers more extensively to tumor in radical cystectomy (RC) specimens. Read More

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December 2020

EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer.

Oncogene 2020 10 25;39(44):6856-6870. Epub 2020 Sep 25.

Institute of Pathology, RWTH Aachen University, Aachen, Germany.

Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle-invasive bladder cancer (MIBC). However, the impact on bladder cancer with substantial squamous differentiation (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n = 125) on genetic and protein expression level, and performed functional pathway and drug-response analyses with cell line models and isolated primary SCC (p-SCC) cells of the human urinary bladder. Read More

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October 2020