2,764 results match your criteria Squamous Cell Carcinoma of the Urinary Bladder


[Clinical experiences of laparoscopic radical cystectomy and urinary diversion in the elderly patients with bladder cancer].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(14):1101-1105

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To optimize the surgical procedures of laparoscopic radical cystectomy and urinary diversion for the elderly patients with bladder cancer, generalize operating technique, summarize clinical experiences. From July 2004 to October 2016, laparoscopic radical cystectomy (LRC) and urinary diversion was performed in 68 elderly patients (≥75 years old) diagnosed with bladder cancer in urology department of Beijing Chaoyang Hospital, Capital Medical University, and the relevant clinical and follow-up data were retrospectively reviewed. All the patients were pathologically diagnosed and their perioperative data, postoperative pathological results, postoperative complications and follow-up outcomes were recorded and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.14.013DOI Listing
April 2019
3 Reads

Multiple primary malignancies of six organs in a Japanese male patient: A case report.

Mol Clin Oncol 2019 May 4;10(5):511-515. Epub 2019 Mar 4.

Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya-ku, Saitama 330-8503, Japan.

As a result of recent advances in diagnostic techniques and treatment modalities, the number of patients diagnosed with multiple primary malignancies has been increasing. We report the case of a 79-year-old male with multiple primary malignancies of three histological types in six different organs: Stomach, prostate, colon, urinary bladder, facial skin and pancreas, in chronological order. The first malignancy was upper gastric cancer diagnosed in 1998. Read More

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http://dx.doi.org/10.3892/mco.2019.1819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449908PMC
May 2019
2 Reads

Spectrum of urogenital tumors in males in Sub-Himalayan region: An institutional experience.

J Cancer Res Ther 2019 Mar;15(Supplement):S82-S86

Department of Urology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of the world. This study was undertaken to analyze the frequency, clinical presentation, and the histopathological spectrum of the various male urogenital tumors diagnosed over a period of 3 years in a tertiary care institute.

Materials And Methods: Three-year data were collected from the histopathology laboratory, which included all the cases of male urogenital tumors which were diagnosed histopathologically between November 2012 and October 2015. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_565_17DOI Listing
March 2019
2 Reads

The impact of variant histological differentiation on extranodal extension and survival in node positive bladder cancer treated with radical cystectomy.

Surg Oncol 2019 Mar 30;28:208-213. Epub 2019 Jan 30.

University Medical Center Hamburg-Eppendorf, Department of Urology, Hamburg, Germany. Electronic address:

Objective: To investigate the impact of variant urothelial carcinoma of the bladder (UCB) histologies on extra nodal extension (ENE) and survival in lymph node (LN) positive bladder cancer patients undergoing radical cystectomy (RC).

Material And Methods: We meticulously reviewed all bladder specimens for presence of variant UCB histologies and LN specimen for presence and extent of ENE in 517 UCB patients treated with RC. Descriptive statistics, the Kaplan Meier method and multivariable Cox regression models evaluated the association between variant UCB histology, ENE and survival metrics including disease recurrence-free, cancer-specific, and overall survival, respectively. Read More

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http://dx.doi.org/10.1016/j.suronc.2019.01.008DOI Listing
March 2019
1 Read

Biomarkers in Non-Schistosomiasis-related squamous cell carcinoma of the urinary bladder: A review.

Crit Rev Oncol Hematol 2019 Mar 25;135:76-84. Epub 2019 Jan 25.

Medical Oncology Department, King Hussein Cancer Center, Amman, Jordan.

Non-urothelial (NU) histologies represent less than 10% of bladder cancers, with squamous cell carcinoma (SCC) being the most common subtype (approximately 5%). Bladder SCCs are subdivided into Schistosoma-related or non-Schistosoma-related tumors, with the latter being the most frequent subtype in the western world. Typically, these patients have been excluded or under-represented in clinical trials and thus little is known about treatment efficacy in bladder SCC. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.01.008DOI Listing
March 2019
1 Read

Metastatic breast carcinoma to the urinary bladder-a report of 11 cases including a tumor to tumor metastasis.

Virchows Arch 2019 Mar 4;474(3):333-339. Epub 2019 Jan 4.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Metastatic breast carcinoma to the urinary bladder is rare. Eleven cases of metastatic breast carcinoma to the bladder are described in this report, including one case with a tumor to tumor metastasis. The patients ranged from 51 to 83 years of age. Read More

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http://dx.doi.org/10.1007/s00428-018-02515-3DOI Listing
March 2019
5 Reads

Treatment of cervical cancer metastatic to the abdominal wall with reconstruction using a composite myocutaneous flap: A case report.

Gynecol Oncol Rep 2019 Feb 12;27:38-41. Epub 2018 Dec 12.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon.

A 43-year-old woman treated with radical hysterectomy 1 year ago for cervical cancer presented with a suprapubic abdominal mass. A 15 cm necrotic mass from the abdominal wall along with 2 small bowel loops and the dome of the bladder were resected. The peritoneal defect was reconstructed with a pedicled anterolateral thigh and Vastus Lateralis muscle composite flap. Read More

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http://dx.doi.org/10.1016/j.gore.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302027PMC
February 2019
7 Reads

Non-urothelial carcinomas of the bladder.

Histopathology 2019 Jan;74(1):97-111

Department of Pathology, University of California at San Diego, La Jolla, CA, USA.

Non-urothelial carcinomas involving the bladder are uncommon and often diagnostically challenging. These carcinomas may show squamous, adenocarcinomatous or neuroendocrine features, with immunohistochemical stains aiding the diagnosis in only a subset of cases. The clinical history in non-urothelial bladder carcinomas is important, given that the differential diagnosis often includes secondary involvement of the bladder by direct extension or metastasis from carcinomas at other sites. Read More

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http://dx.doi.org/10.1111/his.13719DOI Listing
January 2019
2 Reads

Precursor lesions of the urinary bladder.

Authors:
Jesse K McKenney

Histopathology 2019 Jan;74(1):68-76

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.

The classification of neoplastic precursor lesions in the urinary tract has evolved slowly with the gradual accumulation of clinicopathological data. Current nomenclature was codified most recently by the 2016 WHO classification, which is based on primary data with clinical outcome, consensus group statements and considerations of practical utility in routine diagnosis. This review discusses precursor lesions of urothelial, squamous and glandular lineage. Read More

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http://dx.doi.org/10.1111/his.13762DOI Listing
January 2019
5 Reads

Variants and new entities of bladder cancer.

Histopathology 2019 Jan;74(1):77-96

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Pathological evaluation of bladder cancer typically reveals great tumour heterogeneity, and therefore the common observation of urothelial carcinoma exhibiting a wide variety of histopathological patterns is not surprising. Some of these patterns are so distinctive that they have been recognised as specific variants of urothelial carcinoma. Classifications have recently been revised in the 2016 World Health Organisation (WHO) classification of tumours of the urinary system and male genital organs. Read More

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http://dx.doi.org/10.1111/his.13752DOI Listing
January 2019
5 Reads

Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study.

Scand J Urol 2018 Oct - Dec;52(5-6):371-376. Epub 2018 Dec 11.

a Department of Urology , Aarhus University Hospital , Denmark.

Objective: To evaluate a potential association between Human Papillomavirus (H.P.V. Read More

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http://dx.doi.org/10.1080/21681805.2018.1531920DOI Listing
December 2018
6 Reads

Updates on the Genetics and Molecular Subtypes of Urothelial Carcinoma and Select Variants.

Surg Pathol Clin 2018 Dec 17;11(4):713-723. Epub 2018 Oct 17.

Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Urothelial carcinoma is a morphologically and genomically heterogeneous disease that exhibits a wide spectrum of morphologic features and molecular alterations and subtypes. Classic urothelial carcinoma (not otherwise specified) is the most common tumor type that develops in the urinary bladder but many, well-documented, variant histologies are commonly encountered in approximately one-third of invasive urothelial carcinoma, including squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. In this review, we provide an update on the molecular advances in urothelial carcinoma and some of its variant histologies. Read More

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http://dx.doi.org/10.1016/j.path.2018.07.011DOI Listing
December 2018
3 Reads

Pathological Profile, Early Complications, Functional and Oncological Outcome after Radical Cystectomy - Ileal Conduit for Bladder Cancer Patients in Sanglah General Hospital between January 2013 and December 2016.

Open Access Maced J Med Sci 2018 Sep 23;6(9):1647-1651. Epub 2018 Sep 23.

Department of Neurology, Medical Faculty, Udayana University-Sanglah General Hospital, Bali, Indonesia.

Background: Radical cystectomy is the standard treatment for nonmetastatic bladder cancer (muscle-invasive and selective superficial bladder cancer). There are many types of urinary diversion after this procedure; the ileal conduit is the most and simplest one.

Aim: To asses clinical, pathological profile, early complication, functional and oncological outcome after radical cystectomy and ileal conduit for muscle-invasive bladder cancer patients. Read More

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http://dx.doi.org/10.3889/oamjms.2018.384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182542PMC
September 2018
4 Reads

Bladder Tumors with Mixed Histology: What Is the Basis for the Heterogeneity?

Eur Urol 2018 12 28;74(6):754-755. Epub 2018 Sep 28.

Department of Medical Oncology, School of Medicine, University of Nevada, Las Vegas, NV, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183071
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http://dx.doi.org/10.1016/j.eururo.2018.09.031DOI Listing
December 2018
4 Reads

Surgical and oncological outcomes of an improved nerve-sparing radical hysterectomy technique: 6 years of experience at two centres.

Surg Oncol 2018 Sep 25;27(3):380-386. Epub 2018 May 25.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, China. Electronic address:

Objective: An improved nerve-sparing radical hysterectomy (NSRH), which is based on the paravesico-vaginal space, has been recently introduced in a phase II, prospective clinical trial by our team. This study aims to report the surgical and oncological outcomes of this improved NSRH.

Methods: One hundred seventy-seven consecutive patients were enrolled in our study and underwent the improved NSRH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09607404183011
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http://dx.doi.org/10.1016/j.suronc.2018.05.015DOI Listing
September 2018
17 Reads

Clinical Significance of Squamous Differentiation in Urothelial Carcinoma of the Bladder.

Cancer Control 2018 Jan-Dec;25(1):1073274818800269

1 Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.

The prognostic value of squamous differentiation (SD) in urothelial carcinoma (UC) of the bladder is unclear. The aim of this study was to identify the clinical significance of SD in UC in terms of oncological outcomes in patients undergoing radical cystectomy (RC). We evaluated consecutive patients with muscle-invasive bladder cancer (MIBC; clinical T2-4aN0M0) treated with RC at our institution from March 2003 to March 2017. Read More

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http://dx.doi.org/10.1177/1073274818800269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144505PMC
April 2019
3 Reads

Update of the International Consultation on Urological Diseases on bladder cancer 2018: non-urothelial cancers of the urinary bladder.

World J Urol 2019 Jan 1;37(1):107-114. Epub 2018 Aug 1.

Department of Urologic Surgery, University of Minnesota, Minneapolis, MN, USA.

Purpose: To provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder.

Methods: A detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diagnosis, treatment and outcomes of non-urothelial cancer of the urinary bladder. An international, multidisciplinary expert committee evaluated and graded the evidence according to the Oxford System of Evidence-based Medicine modified by the ICUD. Read More

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http://link.springer.com/10.1007/s00345-018-2421-5
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http://dx.doi.org/10.1007/s00345-018-2421-5DOI Listing
January 2019
38 Reads

[Bladder exstrophy with adenocarcinoma in an adult patient: a case report].

Pan Afr Med J 2018 3;29:197. Epub 2018 Apr 3.

Service d'Urologie, CHU Hassan II de Fès, Maroc.

Bladder exstrophy is rare malformation pathology with an incidence of about 1 in 50,000 newborns. Not treated in time exposes to two main complications: kidney failure and bladder plaque cancer with a risk up to 200 times normal, which usually occurs around the fourth and fifth decade. In 95% it is adenocarcinoma and 5% squamous cell carcinoma. Read More

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http://www.panafrican-med-journal.com/content/article/29/197
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http://dx.doi.org/10.11604/pamj.2018.29.197.15291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061861PMC
August 2018
15 Reads

Targeted DNA and RNA Sequencing of Paired Urothelial and Squamous Bladder Cancers Reveals Discordant Genomic and Transcriptomic Events and Unique Therapeutic Implications.

Eur Urol 2018 12 20;74(6):741-753. Epub 2018 Jul 20.

Michigan Center for Translational Pathology, Michigan Medicine, Ann Arbor, MI, USA; Department of Pathology, Michigan Medicine, Ann Arbor, MI, USA; Rogel Cancer Center, Michigan Medicine, Ann Arbor, MI, USA; Department of Urology, Michigan Medicine, Ann Arbor, MI, USA. Electronic address:

Background: Integrated molecular profiling has identified intrinsic expression-based bladder cancer molecular subtypes. Despite frequent histological diversity, robustness of subtypes in paired conventional (urothelial) and squamous components of the same bladder tumor has not been reported.

Objective: To assess the impact of histological heterogeneity on expression-based bladder cancer subtypes. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.06.047DOI Listing
December 2018
18 Reads

What is your diagnosis? Bladder mass in a mare.

Vet Clin Pathol 2018 Dec 16;47(4):665-666. Epub 2018 Jul 16.

Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA.

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http://dx.doi.org/10.1111/vcp.12637DOI Listing
December 2018
2 Reads

The dog as an animal model for bladder and urethral urothelial carcinoma: Comparative epidemiology and histology.

Oncol Lett 2018 Aug 30;16(2):1641-1649. Epub 2018 May 30.

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre-clinical development of novel treatments requires an animal model that accurately simulates the disease in humans. Read More

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http://dx.doi.org/10.3892/ol.2018.8837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036476PMC
August 2018
11 Reads

Psoriasis and cancer. An Australian/New Zealand narrative.

Australas J Dermatol 2019 Feb 10;60(1):12-18. Epub 2018 Jul 10.

Kingsway Dermatology, Miranda, New South Wales, Australia.

Patients with psoriasis have an increased risk of cancer, which may be due to impaired immune surveillance, immune modulatory treatments, chronic inflammation and/or co-risk factors such as obesity. The increase in treatment-independent solid cancers, including urinary/bladder cancers, oropharynx/larynx, liver/gallbladder and colon/rectal cancers, seem to be linked to alcohol and smoking. Lung cancer and nonmelanoma skin cancer are also increased in patients with psoriasis. Read More

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http://dx.doi.org/10.1111/ajd.12889DOI Listing
February 2019
25 Reads

Frequent PD-L1 Protein Expression and Molecular Correlates in Urinary Bladder Squamous Cell Carcinoma.

Eur Urol 2018 10 3;74(4):529-531. Epub 2018 Jul 3.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Rogel Cancer Center, Michigan Medicine, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183044
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http://dx.doi.org/10.1016/j.eururo.2018.06.019DOI Listing
October 2018
20 Reads

Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy."

Urol Oncol 2018 07 5;36(7):347-348. Epub 2018 Jun 5.

Objectives: To investigate for the presence of circulating tumor cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes.

Patients And Methods: We, prospectively, collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.05.013DOI Listing
July 2018
8 Reads

Risk of second primary Cancer among bladder Cancer patients: a population-based cohort study in Korea.

BMC Cancer 2018 May 31;18(1):617. Epub 2018 May 31.

Cancer Registration and Statistics Branch, National Cancer Center, Goyang, Korea.

Background: For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer.

Methods: Using population-based data from the Korea Central Cancer Registry from 1993 to 2013, we studied the standardized incidence ratios among 48,875 individuals with an initial diagnosis of bladder cancer. Read More

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http://dx.doi.org/10.1186/s12885-018-4530-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984459PMC
May 2018
22 Reads

Keratinising squamous cell metaplasia: when is it safe to stop looking?

BMJ Case Rep 2018 May 29;2018. Epub 2018 May 29.

Urology, Barts Health NHS Trust, London, UK.

Keratinising squamous cell metaplasia (KSCM) is an uncommon diagnosis in the West. Patients typically present with lower urinary tract symptoms: haematuria (visible and non-visible), dysuria, urgency and frequency. Investigation is rigid cystoscopy. Read More

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http://dx.doi.org/10.1136/bcr-2017-223822DOI Listing
May 2018
5 Reads

[Spinal cord injury with neurogenic lower urinary tract dysfunction as a potential risk factor for bladder carcinoma].

Aktuelle Urol 2018 May 29. Epub 2018 May 29.

Leibniz-Institut für Arbeitsforschung an der TU Dortmund (IfADo), Dortmund.

Introduction And Objectives:  Life expectancy for people with spinal cord injury/disease (SCI/D) is increasing, due to modern advances in treatment methods and in neuro-urology. However, with the increased life expectancy the risk of developing urinary bladder cancer is gaining importance. How is this patient group different from the general population?

Methods:  Single-centre retrospective evaluation of consecutive patient data with spinal cord injury and proven urinary bladder cancer. Read More

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http://dx.doi.org/10.1055/a-0620-7757DOI Listing
May 2018
8 Reads

Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.

Hum Pathol 2018 Sep 12;79:57-65. Epub 2018 May 12.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:

Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68 years. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133751PMC
September 2018
36 Reads

Pathological characteristics and prognostic indicators of different histopathological types of urinary bladder cancer following radical cystectomy in a large single-center Egyptian cohort.

World J Urol 2018 Nov 14;36(11):1835-1843. Epub 2018 May 14.

Department of Urology, University of California, Irvine, Orange, CA, USA.

Objective: To evaluate differences in pathological features and prognostics across four bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients.

Methods: A retrospective analysis of patients who underwent RC at a single institution in Egypt between 1997 and 2004 was performed. Kaplan-Meier and multivariable analyses were performed to evaluate the prognostic significance of pathological features including tumor stage, grade, lymphovascular invasion (LVI), and lymph node (LN) involvement in the different subtypes on disease-free survival (DFS). Read More

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http://dx.doi.org/10.1007/s00345-018-2331-6DOI Listing
November 2018
6 Reads

Bacillus Calmette-Guérin may have clinical benefit for glandular or squamous differentiation in non-muscle invasive bladder cancer patients: retrospective multicenter study.

Jpn J Clin Oncol 2018 Jul;48(7):661-666

Department of Urology, Sapporo Medical University School of Medicine.

Objectives: To clarify the efficacy of intravesical Bacillus Calmette-Guérin (BCG) instillation for non-muscle invasive bladder (NMIBC) cancer with variant histology, especially glandular differentiation or squamous differentiation.

Materials And Methods: From May 1991 through June 2016, 53 patients were diagnosed retrospectively as having NMIBC with variant histology. Among these patients, 47 NMIBC patients with squamous differentiation or glandular differentiation were analyzed for this study. Read More

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http://dx.doi.org/10.1093/jjco/hyy066DOI Listing
July 2018
12 Reads

Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation?

Adv Urol 2018 13;2018:3453808. Epub 2018 Mar 13.

University of Maryland School of Medicine, Baltimore, MD, USA.

We investigated gender differences in the histopathologic presentation of bladder cancer cases in Egypt, where both urothelial cell carcinoma (UC) and squamous cell carcinoma (SCC) types are highly prevalent. We used logistic regression to estimate the unadjusted (OR) and adjusted odds ratio (AOR) and 95% confidence interval (CI) of the associations between gender and different histopathologic and sociodemographic parameters of 2,186 confirmed cases of primary bladder cancer (1,775 males and 411 females; 784 SCC and 1,402 UC). There were no statistically significant gender differences in tumor grade, stage, mucosal ulcer, or inflammatory cystitis, regardless of the cancer type, but men were less likely than women to have undergone cystectomy with pelvic lymphadenectomy. Read More

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http://dx.doi.org/10.1155/2018/3453808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872673PMC
March 2018
8 Reads

Helminths and Cancers From the Evolutionary Perspective.

Front Med (Lausanne) 2018 16;5:90. Epub 2018 Apr 16.

Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Belo Horizonte, Brazil.

Helminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes (, and ) and liver flukes ( and ) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Read More

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http://dx.doi.org/10.3389/fmed.2018.00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911458PMC
April 2018
3 Reads

Interest of next-generation sequencing in BCG-treated high-risk bladder cancer.

Prog Urol 2018 May 17;28(6):344-350. Epub 2018 Apr 17.

Department of urology, Erasme hospital, université Libre-de-Bruxelles, Brussels, Belgium. Electronic address:

Objectives: There are only few predictive factors for response of non-musculo-invasive bladder cancer (NMIBC) to Bacillus Calmette-Guérin (BCG) therapy. Our study analyzed the results of the sequencing of new generation (NGS) targeted on 50 genes of oncological interest obtained on bladder resection parts in high-risk NMIBC patients treated with BCG, to describe this population from a molecular point of view and try to correlate these results in patients who present or not recurrence after BCG.

Methods: We reviewed 63 patients with high grade NMIBC treated between 2014 and 2016 with BCG after endoscopic resection. Read More

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http://dx.doi.org/10.1016/j.purol.2018.03.008DOI Listing
May 2018
4 Reads

Outcome of Mainz II Pouch Urinary Diversion after Radical Cystectomy in Patients with Muscle-invasive Bladder Cancer: Our Experience.

Niger J Surg 2018 Jan-Jun;24(1):12-15

Department of Surgery, Urology Division, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.

Introduction: Mainz II pouch urinary diversion in patients with muscle-invasive bladder cancer is one of the options of continent urinary diversion following radical cystectomy (RC). We aim to report our experience and the outcome of our patients who had this procedure.

Patients And Methods: Patients who had RC and Mainz II pouch urinary diversion for muscle-invasive bladder cancer in our institution from 2007 to 2016 were evaluated. Read More

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http://dx.doi.org/10.4103/njs.NJS_25_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883843PMC
April 2018
8 Reads

Significance of Perioperative Chemotherapy in Squamous Cell Carcinoma of the Upper and Lower Urinary Tract.

Anticancer Res 2018 04;38(4):2241-2245

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Background/aim: To evaluate the clinicopathological characteristics and prognosis of squamous cell carcinoma (SCC) of the urinary tract (UT) urothelium, and investigate the utility of perioperative chemotherapy.

Patients And Methods: Thirty-three patients diagnosed with SCC in renal pelvis, ureter and bladder at the Kanazawa University between 2007 and 2017 were included in this retrospective study. Cancer-specific survival (CSS) rates according to cancer stage and neoadjuvant chemotherapy (NAC) were determined. Read More

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http://dx.doi.org/10.21873/anticanres.12467DOI Listing
April 2018
8 Reads

Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness.

Cancer Immunol Res 2018 05 27;6(5):528-538. Epub 2018 Mar 27.

Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.

Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of Tregs on certain malignancies, including urinary bladder cancer (UBC). This discrepancy has partly been attributed to the shear misidentification of Tregs, but also to the inflammatory profile of the tumor. Read More

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0466DOI Listing
May 2018
5 Reads

Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.

BMC Res Notes 2018 Mar 27;11(1):207. Epub 2018 Mar 27.

Kandahar University, Kandahar, Afghanistan.

Objectives: Well differentiated keratinized squamous component as a part of urothelial carcinoma can be easily appreciated; however non-keratinizing squamous differentiation closely resembles urothelial differentiation. In addition prognostic significance of CK 5/6 expression in the absence of apparent squamous differentiation is still unclear. Therefore, in the present study we aimed to evaluate the frequency of CK 5/6 expression in 127 cases of urothelial carcinoma and its prognostic significance in loco-regional population. Read More

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http://dx.doi.org/10.1186/s13104-018-3319-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870198PMC
March 2018
10 Reads
1 Citation

The evolution of bladder cancer genomics: What have we learned and how can we use it?

Urol Oncol 2018 Jul 21;36(7):313-320. Epub 2018 Mar 21.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Background: With advancements in molecular biology techniques, great progress has been made in the understanding of urothelial carcinoma pathogenesis.

Objective: To examine the historic description of molecular alterations in bladder cancer and their evolution towards our current comprehension of the biology of the disease.

Results: Historically, a two-pathway model was described from histological and cytogenetic studies: low-grade papillary non-muscle invasive bladder cancers (NMIBC) were described to arise from epithelial hyperplasia with loss of chromosome 9 as an early event, whereas muscle-invasive bladder cancers (MIBC) were considered to develop from dysplasia, associated with genetic instability. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.02.017DOI Listing
July 2018
6 Reads

Focal immune-related pancreatitis occurring after treatment with programmed cell death 1 inhibitors: a distinct form of autoimmune pancreatitis?

Eur J Cancer 2018 05 9;95:123-126. Epub 2018 Mar 9.

Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute IRCCS, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1016/j.ejca.2018.02.006DOI Listing
May 2018
5 Reads

T4 urothelial carcinoma in undiagnosed closed bladder exstrophy in a post-menopausal female.

Can J Urol 2018 02;25(1):9214-9216

Division of Urology, Department of Surgery, Cook County Health and Hospitals System, Chicago, Illinois, USA.

It is rare to see an adult presenting with exstrophy of the bladder. Malignant conversion in exstrophy occurs in 4%, with adenocarcinoma as the most common histopathology. We report the first case of metastatic high grade urothelial carcinoma with squamous and sarcomatoid differentiation arising from undiagnosed, closed bladder exstrophy in a female at advanced age with associated bilateral deep vein thrombosis and clot retention. Read More

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February 2018
5 Reads

Sociodemographic and survival disparities for histologic variants of bladder cancer.

Can J Urol 2018 02;25(1):9179-9185

Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Introduction: To investigate the impact of perioperative factors on overall survival among patients with histologic variants of bladder cancer treated with radical cystectomy.

Materials And Methods: The National Cancer Data Base was utilized to identify patients diagnosed with muscle-invasive bladder cancer (cT2-4, N0, M0) from 2004-2013. Variant histology bladder cancers (non-mucinous adenocarcinoma, mucinous/signet ring adenocarcinoma, micropapillary urothelial carcinoma, small cell carcinoma, and squamous cell carcinoma) were compared to urothelial carcinoma with respect to overall survival. Read More

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February 2018
7 Reads

Analysis of bladder cancer subtypes in neurogenic bladder tumors.

Can J Urol 2018 02;25(1):9161-9167

Sorbonne Université, GRC n°5, ONCOTYPE-URO, AP-HP, Hôpital Pitié-Salpêtrière, F-75013, Paris, France.

Introduction: To establish if the validated tumor biomarkers of luminal and basal bladder cancers in non neuro-urological patients are applicable to a neuro-urological population.

Materials And Methods: We retrieved bladder cancer samples from neuro-urological patients (n = 20) and non-neurological controls (n = 40). The expression of GATA3 and CK5/6 was analyzed using immunohistochemistry of microarray tissue sections. Read More

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February 2018
9 Reads

A case report of squamous cell carcinoma in a suprapubic urinary catheter tract: surgical excision and simultaneous colostomy formation.

J Surg Case Rep 2018 Feb 23;2018(2):rjy030. Epub 2018 Feb 23.

Department of Urology, Royal Devon & Exeter Hospital, Exeter EX2 5DW, UK.

Squamous cell carcinoma (SCC) arising from a suprapubic cystostomy tract is a rare complication of long-term suprapubic catheterization (SPC). A 53-year-old man with paraplegia secondary to spina bifida presented with a painful granulomatous lesion around his SPC site that was being treated with silver nitrate cauterization in the community. Consequently, he developed a sacral pressure sore due to reduced mobility from the pain. Read More

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http://dx.doi.org/10.1093/jscr/rjy030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824828PMC
February 2018
7 Reads

Impact of Cyclin D1 and Heterogeneous Nuclear Ribonucleoprotein-K (HnRNP-K) on Urinary Bladder Carcinogenesis

Asian Pac J Cancer Prev 2018 Feb 26;19(2):513-519. Epub 2018 Feb 26.

Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt. Email:

Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathological findings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studied the immunoexpression; as regard the percentage, intensity and score of both cyclin D1 and hnRNP-K in different bladder lesions including 10 cases of cystitis; 10 cases of carcinoma insitu (CIS), 20 cases of Squamous cell carcinoma (SCC) and 66 cases of urothelial carcinoma (UC). Results: High expression of cyclin D1 was found in UC compared to other groups (p<0. Read More

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http://dx.doi.org/10.22034/APJCP.2018.19.2.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980943PMC
February 2018
4 Reads
1.500 Impact Factor

Alternative transcription of a shorter, non-anti-angiogenic thrombospondin-2 variant in cancer-associated blood vessels.

Oncogene 2018 05 22;37(19):2573-2585. Epub 2018 Feb 22.

Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.

Thrombospondin-2 (TSP2) is an anti-angiogenic matricellular protein that inhibits tumor growth and angiogenesis. Tumor-associated blood vascular endothelial cells (BECs) were isolated from human invasive bladder cancers and from matched normal bladder tissue by immuno-laser capture microdissection. Exon expression profiling analyses revealed a particularly high expression of a short TSP2 transcript containing only the last 9 (3') exons of the full-length TSP2 transcript. Read More

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http://dx.doi.org/10.1038/s41388-018-0129-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945577PMC
May 2018
5 Reads

Chronic urinary tract infection and bladder carcinoma risk: a meta-analysis of case-control and cohort studies.

World J Urol 2018 Jun 5;36(6):839-848. Epub 2018 Feb 5.

Department of Surgery, Farwaniya Hospital, PO Box 33978, Al Rawdha, 7346, Kuwait.

Objective: This meta-analysis of published case-control and cohort studies sought to quantify the magnitude and direction of association between chronic UTI (defined as the infection of the urinary tract that either does not respond to treatment or keeps recurring) and risk of bladder carcinoma (BCa) (i.e., including mainly urothelial carcinoma, squamous cell carcinoma or adenocarcinoma). Read More

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http://dx.doi.org/10.1007/s00345-018-2206-xDOI Listing
June 2018
4 Reads
2.670 Impact Factor

Intermediate-term results of trans-abdominal ultrasound (TAUS)-guided brachytherapy in cervical cancer.

Gynecol Oncol 2018 03 3;148(3):468-473. Epub 2018 Feb 3.

The division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objectives: To report the intermediate-term results of trans-abdominal ultrasound (TAUS)-guided brachytherapy in cervical cancer.

Materials And Methods: Ninety-two patients with cervical cancer (stage IB-IVA, according to FIGO staging), were treated by curative radiotherapy from February 2012 to June 2015. All patients were treated with whole pelvic radiotherapy to 50 Gy in 25 fractions and central shielding after 44 Gy, in combination with TAUS-guided brachytherapy, in order to escalate the total dose (EQD2) to the minimal dose at cervical points (in EQD2 concepts) defined by TAUS, while maintaining low doses to ICRU bladder and rectal points. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.01.015DOI Listing
March 2018
14 Reads
3.774 Impact Factor

Primary vaginal squamous cell carcinoma with bladder involvement in uterine prolapsed patient: Case report.

Medicine (Baltimore) 2017 Dec;96(50):e8993

Institute of Obstetrics and Emergency Medicine, Medical Faculty, University of Rzeszow, Rzeszow, Poland.

Rationale: Primary vaginal squamous cell carcinoma (SCC) is a rare disease. Primary SCC in prolapsed vagina is extremely rare. In the presented case additional bladder involvement was found. Read More

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http://dx.doi.org/10.1097/MD.0000000000008993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815706PMC
December 2017
16 Reads

Squamous Cell Carcinoma of Suprapubic Cystostomy Site in a Patient with Long-Term Suprapubic Urinary Catheter.

Case Rep Urol 2017 12;2017:7940101. Epub 2017 Nov 12.

Department of Urology, Colombo North Teaching Hospital, Ragama, Sri Lanka.

Patients with long-term suprapubic cystostomy can rarely develop squamous cell carcinoma (SCC) of the suprapubic cystostomy tract. In addition to the few reported cases in the literature, this paper reports a case of suprapubic cystostomy SCC in an 88-year-old man without bladder involvement. Vigilance about any abnormal lesion at the site of suprapubic cystostomy is important among health providers and patients for early detection of SCC. Read More

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http://dx.doi.org/10.1155/2017/7940101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702393PMC
November 2017
4 Reads