Search Our Scientific Publications & Authors

Mol Clin Oncol 2018 Aug 4;9(2):197-200. Epub 2018 Jun 4.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.

The incidence of prostatic cancer (PCa) has increased significantly, and the measurement of prostate-specific antigen (PSA) is an effective screening tool for its diagnosis. PCa includes a number of specific clinicopathological types, including squamous cell, urothelial, adenoid cystic and small-cell carcinoma, among which small-cell carcinoma of the prostate (SCCP) is extremely rare, accounting for <0.5% of all PCa cases. Read More

Cancer Epidemiol Biomarkers Prev 2018 Oct 7;27(10):1168-1175. Epub 2018 Aug 7.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.

Several studies have examined association between human papillomaviruses (HPV) and esophageal cancer, but results have been inconsistent. This is the first prospective study to investigate associations between α, β and γ HPV detection in the oral cavity and risk of esophageal cancer. We conducted a nested case-control study among 96,650 cancer-free participants in the American Cancer Society Cancer Prevention Cohort and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Read More

Oncol Lett 2018 Jun 11;15(6):9151-9161. Epub 2018 Apr 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

The aetiology of oral squamous cell carcinoma (OSCC) remains unclear. Numerous single nucleotide polymorphisms (SNPs) associated with cancer have been identified using genome-wide association studies (GWAS). The present study was designed to identify common SNPs associated with cancer susceptibility and to evaluate their involvement in OSCC. Read More

Arch Pathol Lab Med 2018 Jun 12;142(6):730-734. Epub 2018 Mar 12.

From the Department of Pathology and Laboratory Medicine, University of Vermont, Burlington (Dr Butnor); and the Department of Pathology, Duke University, Durham, North Carolina (Drs Pavlisko, Sporn, and Roggli).

Context: - Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed.

Objective: - To assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM. Read More

Eur Rev Med Pharmacol Sci 2017 Oct;21(19):4283-4291

Department of Urology, Tianjin Union Medical Center, Hongqiao District, Tianjin, China.

Objective:   SCCRO/DCUN1D1/DCN1 (squamous cell carcinoma-related oncogene/defective in cullin neddylation 1 domain containing 1/defective in cullin neddylation) is considered as an oncogene, but its role in the prostate cancer (PC) is still not clear. The current study aims to investigate the expression of SCCRO in PC tumor tissues, further its clinical significance, and proliferation inhibiting effect on PC cells in vitro.

Patients And Methods: RT-PCR was used to detect the expression of SCCRO in PC tissue and corresponding adjacent normal tissues from 160 cases, and its relationship with clinical pathological characteristics was analyzed. Read More

Prostate 2017 Nov 6;77(15):1452-1467. Epub 2017 Sep 6.

Center for Cell Signaling, University of Virginia, Charlottesville, Virginia.

Background: Phosphoinositide-3 (PI-3) kinase signaling has a pervasive role in cancer. One of the key effectors of PI-3 kinase signaling is AKT, a kinase that promotes growth and survival in a variety of cancers. Genetically engineered mouse models of prostate cancer have shown that AKT signaling is sufficient to induce prostatic epithelial neoplasia (PIN), but insufficient for progression to adenocarcinoma. Read More

J Immunother Cancer 2017 07 18;5(1):60. Epub 2017 Jul 18.

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut Street, 6th Floor, Philadelphia, PA, 19107, USA.

Background: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function of M2 macrophages is to facilitate wound healing. As such, they are capable of providing metabolic support to a growing tumor, neovascularization, as well as protection from cytotoxic T cells. Read More

Oncogene 2017 08 3;36(31):4381-4392. Epub 2017 Apr 3.

Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene to drive tumor formation and cancer stem cell properties in squamous cell carcinoma. However, with regards to the prostate, while ΔNp63α is expressed in the basal stem cells of the mature gland, during adenocarcinoma development, its expression is lost and its absence is used to clinically diagnose the malignant state. Surprisingly, here we identify a sub-population of bone metastatic prostate cancer cells in the PC3 cell line that express ΔNp63α. Read More

Asian Pac J Cancer Prev 2017 02 1;18(2):491-494. Epub 2017 Feb 1.

Department of Pathology, the University Teaching Hospital of Lomé, Togo.

Background: Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo. Materials and methods: A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). Read More

Clin Nucl Med 2017 Apr;42(4):e218-e220

From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA.

We present a case of an incidentally detected squamous cell carcinoma of the oropharynx on Ga-PSMA-11 PET. A 71-year-old man's condition was diagnosed as prostate carcinoma after a year of rising serum prostate-specific antigen. The staging Ga-PSMA PET/CT demonstrated focal radiotracer uptake in the prostate corresponding to his known primary prostate cancer. Read More

Can Urol Assoc J 2016 Nov-Dec;10(11-12):E392-E394. Epub 2016 Nov 10.

Division of Urology, Memorial University of Newfoundland, St. John's, NL, Canada.

Metastatic involvement of the penis is relatively infrequent. Metastasis of transitional cell carcinoma (TCC) is extremely rare. We report a case of bladder TCC with metastases to the penis that spares the urethra - a finding that, to the best of our knowledge, has not been previously reported. Read More

JCO Precis Oncol 2017 2;2017. Epub 2017 Nov 2.

Foundation Medicine, Inc., Cambridge, MA.

Background: TMPRSS2-ERG gene fusions are frequently found in prostate cancer and are pathognomomic for prostatic origin. In a series of cancer cases assayed with comprehensive genomic profiling (CGP) in the course of clinical care, we reviewed the frequency of TMPRSS2-ERG fusions in patient tumors of various histologic subtypes.

Methods: Frequency of TMPRSS2-ERG fusions was determined in comprehensive genomic profiles from 64,263 cancer cases submitted to Foundation Medicine to assess genomic alterations suggesting benefit from targeted therapy. Read More

Future Sci OA 2015 Nov 1;1(3):FSO18. Epub 2015 Nov 1.

Leo Jenkins Cancer Center, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA; Leo Jenkins Cancer Center, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.

Primary squamous cell carcinoma of the prostate is a unique and rare clinicopathological entity with fewer than 100 cases reported in the literature. Because of its rarity, the optimal management is not well known. Here, we report a case of primary squamous cell carcinoma of the prostate which was treated with definitive concurrent chemo-radiotherapy with excellent outcome along with a brief review of the literature. Read More

N Engl J Med 2016 12;375(25):2481-2488

From the Departments of Radiation Oncology (T.S.H., P.J.G.), Hematology (J.N.A.), Surgery (P.C.S.), Radiology (K.P.L.), and Pathology (L.R.Z.), Massachusetts General Hospital, and the Departments of Radiation Oncology (T.S.H., P.J.G.), Hematology (J.N.A.), Surgery (P.C.S.), Radiology (K.P.L.), and Pathology (L.R.Z.), Harvard Medical School - both in Boston.

Oncol Rep 2016 Nov 7;36(5):3058-3064. Epub 2016 Sep 7.

Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR)/ErbB2, has antiproliferative effects and is used to treat patients with ErbB2-positive metastatic breast cancer. In the present study, we examined the effects of lapatinib on growth of oral and prostate cancer cells. Oral squamous cell carcinoma (OSCC) cell lines HSC3, HSC4 and Ca9-22 were sensitive to the antiproliferative effects of lapatinib in anchorage-dependent culture, but the OSCC cell lines KB and SAS and the prostate cancer cell line DU145 were resistant to lapatinib. Read More

Appl Immunohistochem Mol Morphol 2017 09;25(8):e71-e73

Department of Pathology, University of Illinois at Chicago, Chicago, IL.

Radiographics 2016 Sep-Oct;36(5):1339-53

From the Department of Radiology, University of Texas Health Science Center, 6431 Fannin St, MSB 2.130, Houston, TX 77030 (V.R.S.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M., A.K.H.); Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (A.M.A., M.E., K.M.E.); Department of Radiology, University of Texas Health Science Center, San Antonio, Tex (V.S.K.); Department of Radiology, MetroHealth Medical Center, Cleveland, Ohio (W.C.B.); Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada (A.K.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (C.L.S.).

Tumors and tumorlike conditions of the anus and perianal region originate from the anal canal and anal margin or result from direct extension of tumors from adjacent organs. The anatomy of the anal canal is complex, and its different histologic characteristics can lead to diverse pathologic conditions. The anal canal extends from the anorectal junction to the anal verge. Read More

Hinyokika Kiyo 2016 May;62(5):259-64

The Department of Pathology, JA Onomichi General Hospital.

The patient was a 73-year-old man who visited our hospital with asymptomatic gross hematuria. Cystoscopy revealed a bladder tumor in two places. Serum prostatic specific antigen was normal (2. Read More

BMJ Case Rep 2016 Jun 15;2016. Epub 2016 Jun 15.

Department of Pathology, Shifa International Hospital Islamabad, Islamabad, Pakistan.

Verrucous carcinoma (VC) is a locally invasive, non-metastasising well differentiated variant of squamous cell carcinoma. It is very rare in the urinary bladder and mostly associated with schistosomiasis. It has a characteristic multilobular appearance with small surface projections on contrast cystogram. Read More

J Oral Maxillofac Surg 2016 Dec 20;74(12):2515-2520. Epub 2016 May 20.

Professor and Kelly L. Krahwinkel Chairman, Director of Oral and Maxillofacial Surgery Residency Program, Department of Oral and Maxillofacial Surgery, University of Tennessee Medical Center, and Director of Oral/Head and Neck Oncologic Surgery Fellowship Program, University of Tennessee Cancer Institute, Knoxville, TN. Electronic address:

Purpose: The purpose of the present study was to determine the rate of second primary head and neck cancer development among patients with a primary cancer diagnosed outside the head and neck region, to present the clinical characteristics of this population, and to determine whether any variables are associated with survival.

Patients And Methods: We designed a case series based on a sample of patients diagnosed with head and neck cancer who had previously been diagnosed with cancer located outside the head and neck region. The primary predictor variable was a diagnosis of cancer outside the head and neck region. Read More

APMIS 2016 Aug 20;124(8):719-22. Epub 2016 May 20.

Department of Pathology, John H. Stroger Jr Hospital of Cook County (CCHS), Chicago, IL.

Clin Nucl Med 2016 Aug;41(8):629-31

From the *Department of Radiology, UNC-Chapel Hill Memorial Hospital, Chapel Hill, NC; and †Department of Radiology, Duke University Medical Center, Durham, NC.

We present a case of carcinosarcoma of the prostate. Workup of urinary retention after a previously treated squamous cell carcinoma of the prostate led to a transurethral prostate resection revealing carcinosarcoma of the prostate, which on F-FDG PET/CT demonstrated moderate to high avidity of this atypical prostate cancer, with partial obstruction of the urinary system and lung metastases. While FDG PET is not avid for typical prostatic adenocarcinomas, it should be considered for evaluation of atypical prostate cancers. Read More

Medicine (Baltimore) 2016 May;95(19):e3642

From the Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari (GLucarelli, MS, AV, SP, CM, MM, SF, MC, OC, FSchiralli, FSebastiani, FD, CBettocchi, PD, MB); Division of General Surgery, Polyclinic Hospital (LV), Bari; Department of Clinical Medicine, Medical Oncology Unit, Federico II University, Naples (GD, CBuonerba); and Department of Urology, Minimally Invasive and Robotic Surgery Center "F. Miulli", Acquaviva della Fonti (GLudovico), Italy.

Primary urethral carcinoma (PUC) is a rare and aggressive cancer, often underdetected and consequently unsatisfactorily treated. We report a case of advanced PUC, surgically treated with combined approaches.A 47-year-old man underwent transurethral resection of a urethral lesion with histological evidence of a poorly differentiated squamous cancer of the bulbomembranous urethra. Read More

ORL J Otorhinolaryngol Relat Spec 2016 25;78(2):61-9. Epub 2016 Feb 25.

Department of Otolaryngology - Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Mich., USA.

Background/aims: Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for second primary malignancies (SPMs). The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC. Read More

JAMA Oncol 2016 Jan 21. Epub 2016 Jan 21.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York3Department of Pediatrics (Genetics), Albert Einstein College of Medicine, Bronx, New York6Departments of Microbiology and Immunology and Obstetrics, Gyn.

Importance: Prospective studies are needed to examine the temporal relationship between oral human papillomavirus (HPV) detection and risk of head and neck squamous cell carcinoma (HNSCC). Moreover, the oral cavity contains a wide spectrum of α-, β-, and γ-HPV types, but their association with risk of HNSCC is unknown.

Objective: To prospectively examine associations between α-, β-, and γ-HPV detection in the oral cavity and incident HNSCC. Read More

Nihon Hinyokika Gakkai Zasshi 2016 ;107(4):266-270

Department of Urology, Jikei University School of Medicine.

Carcinosarcoma of the prostate is a rare but aggressive tumor characterized by combination of malignant epithelial and mesenchymal cells. We encountered a case of carcinosarcoma of the prostate. A 78-year-old man with urinary retention was diagnosed with benign prostatic hyperplasia on the basis of the ultrasonography and rectal examination findings, negative result of prostate biopsy. Read More

Expert Rev Mol Diagn 2016 18;16(2):165-72. Epub 2016 Jan 18.

a The School of Biomedical Sciences, Institute of Health and Biomedical Innovation , Queensland University of Technology , Kelvin Grove , Australia.

Head and neck cancer patients often present with advanced metastatic disease resulting in a poor 5-year survival. Therefore, there is a need for non-invasive diagnostic tools that could complement conventional imaging to inform clinicians of patient outcomes and treatment responses. A liquid biopsy addresses this unmet clinical need; a simple peripheral blood draw could provide information about the disseminated disease in terms of circulating tumor cells and circulating tumor DNA. Read More

Radiother Oncol 2015 Sep 10;116(3):346-51. Epub 2015 Jul 10.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

Background And Purpose: A 15-gene hypoxia profile has previously demonstrated to have both prognostic and predictive impact for hypoxic modification in squamous cell carcinoma of the head and neck. This gene expression profile may also have a prognostic value in other histological cancer types, and could potentially have a function as a universal hypoxia profile. The hypoxia induced upregulation of the included genes, and the validity of the previously used reference genes was established in this study, in a range of different cell lines representing carcinomas of the prostate, colon, and esophagus. Read More

Am J Surg Pathol 2015 Oct;39(10):1305-12

*Laboratory of Pathology †Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD.

Brachyury is a transcription factor of the T-box family typically expressed in notochord and chordoma. Some studies report brachyury as highly specific for chordoma, whereas others have concluded that brachyury is expressed in many types of common carcinomas by reverse transcription polymerase chain reaction and immunohistochemistry and could be involved in the epithelial-mesenchymal transition and metastatic process. In this study, we immunohistochemically evaluated 5229 different tumors for nuclear brachyury expression using a new rabbit monoclonal antibody and automated immunostaining (Leica Bond Max). Read More

Pan Afr Med J 2015 16;20:46. Epub 2015 Jan 16.

National Hospital Abuja, Nigeria.

Introduction: Diagnosis of prostatic diseases with Immunohistochemistry still faces challenges because of the peculiar histology of the prostate and difference(s) in reactivity of Monoclonal antibodies (MoAb) to benign and malignant changes.

Methods: Thirty (30) archived paraffin embedded tissue samples from primary prostate tumors (15 Benign Prostatic Hyperplasia (BPH) and 15 Cancer of the prostate (CaP)) were sectioned at thickness of 5 µm and confirmed as BPH or CaP. Sections from each sample were stained by Immunohistochemistry using the Streptavidin-biotin method and using CK5/6, CK7, CK8,CK20 and Ki67 antibodies (Zymed Antibody products). Read More

Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47

Apart from the typical acinar morphology observed in more than 90% of prostatic adenocarcinomas, a spectrum of morphological variants and prostate cancer subtypes exists. Two nosologically different groups can be distinguished: the variants of conventional acinar cancer and cancers with histological pattern, which are unusual for the prostate. Variants of conventional prostate cancer (pseudohyperplastic, foamy gland, hypernephroid, atrophic, microcystic, with Paneth cell-like changes, with collagenous micronodules, with glomeruloid formations, oncocytic) do not have any known prognostic significance and are graded according to the Gleason system. Read More

Nephrol Ther 2015 Apr 21;11(2):122-4. Epub 2015 Feb 21.

Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. Electronic address:

Tumour markers are high molecular weight glycoproteins whose interpretation in the presence of chronic renal disease may be disturbed. Apart from the prostate specific antigen, human chorionic gonadotropin and α-fetoprotein, their levels rise with chronic renal failure. For some markers, such as carcinoembryonic antigen, carcinogen antigen (CA) 15-3, cytokeratin fragment 21-1 or calcitonin, a threshold may be defined in a population with chronic renal failure, which may allow their use in cancer surveillance. Read More

BMC Res Notes 2014 Dec 15;7:909. Epub 2014 Dec 15.

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Background: Human papillomavirus is associated with urogenital carcinogenesis such as penile and uterine cervix cancer. On the other hand, association between human papillomavirus infection and risk of bladder and prostatic cancer remains controversial.

Case Presentation: We report a rare case of a 67-year-old Japanese man with synchronous triple urogenital cancer including bladder small cell carcinoma, prostatic ductal adenocarcinoma, and penile squamous cell carcinoma, who presented with a history of asymptomatic gross hematuria. Read More

Eur J Cancer Prev 2015 Mar;24(2):150-4

aVaud Cancer Registry and Cancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne bNeuchâtel Cancer Registry, Department of Health and Social Affairs, Neuchâtel, Switzerland cDepartment of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri' dDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.

An increasing proportion of new cancers is registered in patients who have received a previous cancer diagnosis. As data are inconsistent across studies, we provided information for populations long covered by valid cancer registration. Data were derived from the Swiss cancer Registries of Vaud and Neuchâtel (885,000 inhabitants). Read More

World J Surg Oncol 2014 Sep 22;12:294. Epub 2014 Sep 22.

Department of Urology, Tokyo Teishin Hospital, 2-14-23 Fujimi, Chiyoda-ku, Tokyo 102-8798, Japan.

Owing to recent advances in diagnostic and surgical techniques for cancer, a patient diagnosed with two or more neoplasms is not rare. We report on the case of a 58-year-old male with multiple primary malignant neoplasms, who suffered from three histological types of malignant neoplasm in six organs, namely the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in chronological order. The first neoplasm was a squamous cell carcinoma of the glottis diagnosed in 2006. Read More

Am J Surg Pathol 2015 Jan;39(1):67-74

*Department of Pathology and Laboratory Medicine, Emory University Hospital and School of Medicine, Atlanta, GA †The Johns Hopkins Hospital and School of Medicine, Baltimore, MD.

Twenty-nine men with metastatic prostate adenocarcinoma to the penis were identified at our institution between 1993 and 2013. Of the 29 patients, 19 had a prior history of adenocarcinoma of the prostate, and 8 of those had ductal features in the primary lesion. Sixteen of 29 revealed ductal features in the metastasis. Read More

Cent European J Urol 2014 17;67(1):26-8. Epub 2014 Apr 17.

Urology Department, Kettering General Hospital, Northamptonshire, United Kingdom.

Squamous cell carcinoma (SCC) is a rare variant of prostate cancer. We report a case of a patient who was diagnosed with metastatic adenocarcinoma of the prostate, treated with leuprorelin and subsequently found to have SCC 18 months later. We have found one case in the literature with a similar scenario of possible transformation of adenocarcinoma to SCC secondary to luteinizing hormone-releasing hormone (LHRH) treatment. Read More

Case Rep Med 2014 24;2014:860570. Epub 2014 Mar 24.

Department of Nuclear Medicine, Faculty of Medicine, Selcuk University, Selcuklu, Konya, Turkey.

Primary squamous cell carcinoma is an uncommon tumor of the prostate gland. We report a 77-year-old male patient with urinary frequency and constipation. Fine needle biopsy from prostate was suspicious of squamous cell carcinoma of the prostate. Read More

Clin Nucl Med 2015 Jan;40(1):93-5

From the *Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; †Institute of Pathology, Locarno, Switzerland; and ‡Chair of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Italy.

We report a case of squamous cell carcinoma of the tonsil incidentally detected by F-choline PET/CT. A 55-year-old male patient with a history of prostate cancer underwent F-choline PET/CT for restaging. PET/CT revealed a focal area of increased F-choline uptake corresponding to the left tonsil. Read More

Clin Nucl Med 2014 Oct;39(10):e442-4

From the *Department of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Italy; †Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; and ‡Second Division of Pathological Anatomy, University of Brescia and Spedali Civili di Brescia, Italy.

A 75-years-old patient with a history of prostate cancer, previously treated with radical prostatectomy, underwent C-choline PET/CT for restaging due to a rise in the prostate-specific antigen level. The study revealed a focal uptake of C-choline in the esophagus. A subsequent endoscopic examination showed the presence of an esophageal lesion, and after surgery, the histologic diagnosis was mildly differentiated squamous cell carcinoma. Read More

Arch Pathol Lab Med 2014 Oct 14;138(10):1358-64. Epub 2014 Feb 14.

From the Department of Research and Development, Biocare Medical, LLC, Concord, California (Drs Tacha, Bremer, and Qi); and the Department of Pathology, Mercy General Hospital, Janesville, Wisconsin (Dr Haas).

Context: Immunohistochemistry is important to the pathologist for accurate diagnosis of lung cancer. In recent studies, a rabbit polyclonal p40 (RPp40) antibody demonstrated equivalent staining versus anti-p63 in lung squamous cell carcinoma, and superior specificity because it stains a lesser percentage of lung adenocarcinoma.

Objectives: To develop an anti-p40 mouse monoclonal antibody (MMp40) for immunohistochemistry, and to evaluate its sensitivity and specificity in normal and neoplastic tissues, with emphasis on lung cancer. Read More

Am J Surg Pathol 2014 Jul;38(7):941-5

Departments of *Pathology †Urology ‡Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD.

High-grade prostate adenocarcinoma can have overlapping morphologic features with high-grade urothelial carcinoma, a critical distinction as treatments differ substantially. Pseudopapillary features have not previously been described in high-grade acinar prostate adenocarcinoma. We reviewed our consult cases (2006 to 2013) for cases of high-grade prostate adenocarcinoma, in which the Gleason score was equal to 5+4=9 or 5+5=10, and the differential diagnosis included high-grade urothelial carcinoma. Read More

Clin Nucl Med 2014 Jul;39(7):650-2

From the Departments of *Nuclear Medicine, †Radiology, and ‡Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Primary squamous cell carcinoma (SCC) of the prostate is a rare aggressive neoplasm with a poor prognosis. A 60-year-old man presented with urinary frequency and interrupted urination for 4 months. Serum prostate-specific antigen and SCC antigen were elevated. Read More

Proc Natl Acad Sci U S A 2013 May 25;110(20):8105-10. Epub 2013 Apr 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

The tumor protein p63 (p63), and more specifically the NH2-terminal truncated (ΔN) p63 isoform, is a marker of basal epithelial cells and is required for normal development of several epithelial tissues, including the bladder and prostate glands. Although p63-expressing cells are proposed to be the stem cells of the developing prostate epithelium and bladder urothelium, cell lineages in these endoderm-derived epithelia remain highly controversial, and rigorous lineage tracing studies are warranted. Here, we generated knock-in mice expressing Cre recombinase (Cre) under the control of the endogenous ΔNp63 promoter. Read More

Int J Clin Exp Pathol 2013 15;6(4):669-77. Epub 2013 Mar 15.

Department of Hematology and Hematological Laboratory Science, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China.

URI, or RMP, is a RNA polymerase II subunit RPB5-associated protein known to play essential roles in ubiquitination and transcription. Recently, we and others have shown that URI/RMP is also important for progression of hepatocellular carcinoma, ovarian, and prostate cancers. To identify the mechanistic basis of URI/RMP during multiple cellular processes, we investigated URI/RMP expression in a tissue microarray (TMA) containing multiple normal human tissues. Read More

Quant Imaging Med Surg 2012 Dec;2(4):294-5

Department of Radiology, Nanjing 210008, China;

Squamous cell carcinoma of the prostate is very rare, making less than 1% of all prostatic malignancies. We report a case of primary squamous cell carcinoma involving the prostate in an 80-year-old man with a history of benign prostatic hyperplasia, the patient underwent a transurethral resection prostate (TURP) procedure for progressive urinary obstruction. Biopsy proved the tumor to be squamous cell carcinoma. Read More

Hinyokika Kiyo 2012 Aug;58(8):457-60

The Department of Urology, Nagahama City Kohoku Hospital.

We report a case of squamous differentiated prostate carcinoma that developed after combination endocrine therapy for adenocarcinoma of the prostate. The patient was a 68-year-old man who visited our hospital with microscopic hematuria. His serum prostate-specific antigen (PSA) level was 7. Read More

Radiographics 2012 Jul-Aug;32(4):1031-46

Department of Radiology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Genitourinary schistosomiasis is produced by Schistosoma haematobium, a species of fluke that is endemic to Africa and the Middle East, and causes substantial morbidity and mortality in those regions. It also may be seen elsewhere, as a result of travel or immigration. S haematobium, one of the five fluke species that account for most human cases of schistosomiasis, is the only species that infects the genitourinary system, where it may lead to a wide spectrum of clinical symptoms and signs. Read More

PLoS One 2012 18;7(5):e37446. Epub 2012 May 18.

Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, China.

PARP-1 is a nuclear enzyme that plays an important role in DNA repair, recombination, proliferation and the genome stability. The PARP-1 Val762Ala polymorphism has been associated with increased risk of developing cancers of the prostate, esophagus and lung. The aim of this study was to determine whether the PARP-1 Val762Ala polymorphism is associated with the risk of cervical carcinoma. Read More

Cancer Epidemiol 2012 Oct 14;36(5):470-5. Epub 2012 Apr 14.

Medical College of Shandong University, Department of Radiation Oncology, Shandong Cancer Hospital, 44# Wenhua Xi Road, Jinan 250012, Shandong, China.

Objective: To investigate the clinical value in detecting occult primary tumors with (18)F-FDG PET-CT whole body imaging.

Methods: 120 patients with unknown primary origin were referred for (18)F-FDG PET-CT whole body imaging. All patients were performed (18)F-FDG PET-CT whole body scan. Read More