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Arch Pathol Lab Med 2021 May 13. Epub 2021 May 13.

the Department of Laboratory Medicine, University of Washington, Seattle (Greene).

Context.—: Transgender women experience health disparities in all areas of medicine. Within surgical pathology, knowledge gaps relating to the concepts of transgender care exist. Read More

Pol Arch Intern Med 2021 Apr 24;131(4):379-380. Epub 2021 Feb 24.

IJU Case Rep 2020 Jul 20;3(4):121-124. Epub 2020 Apr 20.

Department of Urology Kyoto Prefectural University of Medicine Kyoto Japan.

Introduction: Secondary bladder, colon, and rectal cancers are relatively common after prostate radiotherapy. However, secondary squamous cell carcinoma of the prostate is rare.

Case Presentation: An 85-year-old man presented with dysuria and low-serum prostate-specific antigen levels. Read More

EMBO Mol Med 2021 Feb 29;13(2):e11902. Epub 2020 Dec 29.

Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tuebingen, German Cancer Consortium (DKTK), Partner Site Tuebingen, Tuebingen, Germany.

The prostate-specific membrane antigen (PSMA) has been demonstrated in numerous studies to be expressed specifically on prostate carcinoma cells and on the neovasculature of several other cancer entities. However, the simultaneous expression of PSMA on both, tumor cells as well as tumor vessels remains unclear, even if such "dual" expression would constitute an important asset to facilitate sufficient influx of effector cells to a given tumor site. We report here on the generation of a PSMA antibody, termed 10B3, which exerts superior dual reactivity on sections of prostate carcinoma and squamous cell carcinoma of the lung. Read More

Arch Pathol Lab Med 2020 Oct 22. Epub 2020 Oct 22.

From the Department of Pathology, University of Michigan Medical School, Ann Arbor.

Context.—: While the vast majority of cervical tumors consist of human papillomavirus (HPV)-related squamous cell carcinoma or adenocarcinoma, a subset of rare tumor types, frequently unrelated to HPV, does occur in this location. These tumors vary widely in prognostic and therapeutic implications, and accurate recognition is crucial to providing appropriate treatment. Read More

Ann Diagn Pathol 2020 Oct 14;48:151593. Epub 2020 Aug 14.

University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

The urinary bladder may be involved by a variety of secondary tumors that originate from other organs. Bladder secondary tumors are rare and may be mistaken as bladder primary tumors because of their overlapping morphologic features. To avoid the diagnostic pitfalls, we analyzed the clinicopathologic features of bladder secondary tumors in a large cohort of patients. Read More

Clin Nucl Med 2021 Feb;46(2):e86-e87

From the Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology.

Abstract: A 71-year-old man underwent 18F-FDG and 68Ga-FAPI-46 PET/CT for initial staging prior to surgery of a squamous cell carcinoma of the lower esophagus under the prospective study NCT04147494. Both scans showed increased uptake in the mid and distal esophagus without evidence of metastatic disease. A soft tissue right infrascapular mass with mild 18F-FDG and moderate 68Ga-FAPI-46 uptake was incidentally found. Read More

Transl Lung Cancer Res 2020 Jun;9(3):575-586

Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.

Background: Both antibody-dependent cellular cytotoxicity and phagocytosis activate innate immunity, and the Fc gamma receptor (FCGR)-mediated phagocytosis is an integral part of the process. We assessed associations between single-nucleotide polymorphisms (SNPs) in FCGR-related genes and survival of patients with non-small cell lung cancer (NSCLC).

Methods: We evaluated associations between 24,734 (SNPs) in 97 FCGR-related genes and survival of 1,185 patients with NSCLC using a published genome-wide association study (GWAS) dataset from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and validated the results in another independent dataset of 894 NSCLC patients. Read More

Surg Today 2021 Jan 7;51(1):153-158. Epub 2020 Jul 7.

Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: We evaluated the efficacy of the long-term follow-up of patients who underwent radical esophagectomy for esophageal squamous cell carcinoma (ESCC) to screen for recurrence and new primary malignancies.

Methods: We retrospectively collected 448 ESCC patients who underwent radical esophagectomy. Esophagogastroduodenoscopy, computed tomography, a stool test and the assessment of the serum concentration of squamous cell carcinoma antigen and carcinoembryonic antigen were performed annually, even over 5 years after esophagectomy. Read More

Diagn Cytopathol 2020 Dec 6;48(12):E14-E17. Epub 2020 Jul 6.

VA Palo Alto Health Care System, Pathology and Laboratory Service, Palo Alto, California, USA.

Squamous cell carcinoma (SCC) of the prostate is a rare and clinically aggressive entity that may arise de novo or through transformation of prostatic adenocarcinoma, typically following hormonal or radiation therapy. Confirmation of prostatic origin, especially when evaluating a metastatic focus, often requires correlation with clinical and imaging findings, as the morphologic and immunohistochemical features of SCC are not organ-specific. Comprehensive genomic profiling (CGP) may provide additional information useful for confirming the primary site and for identifying potential targeted therapy options. Read More

Eur Urol Oncol 2020 08 27;3(4):424-432. Epub 2020 Jun 27.

Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

Context: Primary urethral carcinoma (PUC) is a rare cancer accounting for <1% of all genitourinary malignancies.

Objective: To provide updated practical recommendations for the diagnosis and management of PUC.

Evidence Acquisition: A systematic search interrogating Ovid (Medline), EMBASE, and the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews was performed. Read More

Clin Nucl Med 2020 Jun;45(6):465-467

From the Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou.

A 51-year-old man with 30-year neurofibromatosis and 2-month elevated prostate-specific antigen and back pain underwent a Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for possible prostate cancer. Prostate-specific membrane antigen PET/CT imaging showed no abnormal uptake of the prostate. However, in addition to PSMA uptake in his left lung, thorax, and right ilium, which was confirmed being a lung squamous cell carcinoma by a lung biopsy, widespread uptake was also observed in his skin fibroma lesions. Read More

Br J Biomed Sci 2020 Jul 29;77(3):135-141. Epub 2020 Apr 29.

Life Sciences, University of Westminster , London, UK.

Background: MicroRNAs (miRNAs) regulate the translation of mRNA during gene expression and investigations have highlighted their importance in pathophysiology. qRT-PCR is currently the gold standard method for detecting changes in miRNA expression. However, when used on heterogeneous samples, it cannot identify individual cell types harbouring miRNAs. Read More

Exp Mol Pathol 2020 06 24;114:104429. Epub 2020 Mar 24.

Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

The critical roles of long non-coding RNAs (lncRNAs) in the regulation of diverse biological functions has potentiated them as cancer biomarkers. Among these transcripts is the prostate cancer associated transcript 1 (PCAT1) which has been initially shown to exert oncogenic roles in prostate cancer. Further studies revealed its similar roles in various kinds of human malignancies including both solid tumors and hematological malignancies. Read More

Cureus 2019 Nov 18;11(11):e6184. Epub 2019 Nov 18.

Pathology, University of Central Florida College of Medicine, Orlando, USA.

Prostatic squamous cell carcinoma comprises less than 1% of reported prostate cancers. This form of cancer has a poor prognosis with a low survival time following diagnosis and no definitive form of treatment. A Caucasian male cadaver presented with primary pure squamous cell carcinoma of the prostate with metastasis to the liver and local invasion of the bladder, ureter, and rectum. Read More

Pan Afr Med J 2019 1;34:125. Epub 2019 Nov 1.

Université de Tunis El Manar, Faculté de Médecine de Tunis, 1007, Tunis, Tunisie.

Squamous cell carcinoma of the prostate is rare and represents 0.5% to 1% of prostatic carcinomas. Transformation of prostatic adenocarcinoma into squamous cell carcinoma after LH-RH agonist intake has been reported in only 8 cases in the literature. Read More

Prostate 2019 08 18;79(11):1316-1325. Epub 2019 Jun 18.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Urogenital infection with Schistosoma haematobium is a risk factor for the development of squamous cell carcinoma of the urinary bladder. The pathophysiology is thought to be mediated in part by inflammation, cellular damage, and bladder regeneration induced by the parasitic infection. Herein, we report an unusual case of schistosomiasis of the prostate that was found concurrent with prostate adenocarcinoma in a radical prostatectomy specimen from a man in the United States. Read More

J Endourol Case Rep 2019 30;5(2):68-70. Epub 2019 May 30.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Localized prostate cancer rarely undergoes a shift in metabolism towards aerobic glycolysis, a process known as the Warburg Effect. Because of this, positron emission tomography (PET)/CT imaging using 2-deoxy-2-[F]fluoro-d-glucose (F-FDG) is uncommonly used to evaluate patients with early-stage prostate cancer. However, men undergoing an F-FDG PET/CT for unrelated reasons will on occasion be found to have radiotracer uptake within the prostate gland. Read More

Mol Clin Oncol 2019 May 4;10(5):511-515. Epub 2019 Mar 4.

Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya-ku, Saitama 330-8503, Japan.

As a result of recent advances in diagnostic techniques and treatment modalities, the number of patients diagnosed with multiple primary malignancies has been increasing. We report the case of a 79-year-old male with multiple primary malignancies of three histological types in six different organs: Stomach, prostate, colon, urinary bladder, facial skin and pancreas, in chronological order. The first malignancy was upper gastric cancer diagnosed in 1998. Read More

Clin Nucl Med 2019 May;44(5):e367-e369

From the Division of Nuclear Medicine, Department of Radiology and Biomedical Imaging.

We present a case of oropharyngeal squamous cell carcinoma (SCC) of the tongue base incidentally detected on F-fluciclovine PET/CT. A 79-year-old man with history of locally advanced prostate cancer (Gleason score 4 + 5 = 9; cT2cN1M0) previously treated with androgen deprivation therapy (luprolide + bicalutamide) presented with a slowly rising serum prostate-specific antigen over 3 years, concerning for recurrent disease. F-fluciclovine PET/CT, obtained to identify potential sites of recurrence, demonstrated prostate bed uptake with possible left seminal vesicle involvement. Read More

Radiol Case Rep 2019 Apr 11;14(4):483-489. Epub 2019 Feb 11.

Department of Radiology, Donnam Institute of Radiological and Medical Science, 40, Jwadong-gil, Jangan-eup, Gijang-gun, Busan 46033, Republic of Korea.

Squamous cell carcinoma (SCC) of the prostate is a rare tumor with aggressive nature. This type of tumor has a poor response to conventional treatment and results in poor prognosis. Squamous differentiation or metaplasia may arise subsequent to endocrine or radiation treatment, but it is very rare. Read More

Nihon Hinyokika Gakkai Zasshi 2019 ;110(2):129-133

Department of Clinical Laboratory, Takarazuka City Hospital.

SQUAMOUS CELL CARCINOMA, prostate carcinoma, The patient was a 67-year-old man who visited our hospital with urge incontinence. His serum prostatic specific antigen level was normal (1.191 ng/mL). Read More

Mol Clin Oncol 2018 Aug 4;9(2):197-200. Epub 2018 Jun 4.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.

The incidence of prostatic cancer (PCa) has increased significantly, and the measurement of prostate-specific antigen (PSA) is an effective screening tool for its diagnosis. PCa includes a number of specific clinicopathological types, including squamous cell, urothelial, adenoid cystic and small-cell carcinoma, among which small-cell carcinoma of the prostate (SCCP) is extremely rare, accounting for <0.5% of all PCa cases. Read More

Cancer Epidemiol Biomarkers Prev 2018 10 7;27(10):1168-1175. Epub 2018 Aug 7.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.

Several studies have examined association between human papillomaviruses (HPV) and esophageal cancer, but results have been inconsistent. This is the first prospective study to investigate associations between α, β and γ HPV detection in the oral cavity and risk of esophageal cancer. We conducted a nested case-control study among 96,650 cancer-free participants in the American Cancer Society Cancer Prevention Cohort and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Read More

Oncol Lett 2018 Jun 11;15(6):9151-9161. Epub 2018 Apr 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

The aetiology of oral squamous cell carcinoma (OSCC) remains unclear. Numerous single nucleotide polymorphisms (SNPs) associated with cancer have been identified using genome-wide association studies (GWAS). The present study was designed to identify common SNPs associated with cancer susceptibility and to evaluate their involvement in OSCC. Read More

Arch Pathol Lab Med 2018 06 12;142(6):730-734. Epub 2018 Mar 12.

From the Department of Pathology and Laboratory Medicine, University of Vermont, Burlington (Dr Butnor); and the Department of Pathology, Duke University, Durham, North Carolina (Drs Pavlisko, Sporn, and Roggli).

Context: - Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed.

Objective: - To assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM. Read More

JAMA Oncol 2018 Mar;4(3):358-365

NYU Perlmutter Cancer Center, New York University School of Medicine, New York.

Importance: Case-control studies show a possible relationship between oral bacteria and head and neck squamous cell cancer (HNSCC). Prospective studies are needed to examine the temporal relationship between oral microbiome and subsequent risk of HNSCC.

Objective: To prospectively examine associations between the oral microbiome and incident HNSCC. Read More

Eur Rev Med Pharmacol Sci 2017 Oct;21(19):4283-4291

Department of Urology, Tianjin Union Medical Center, Hongqiao District, Tianjin, China.

Objective:   SCCRO/DCUN1D1/DCN1 (squamous cell carcinoma-related oncogene/defective in cullin neddylation 1 domain containing 1/defective in cullin neddylation) is considered as an oncogene, but its role in the prostate cancer (PC) is still not clear. The current study aims to investigate the expression of SCCRO in PC tumor tissues, further its clinical significance, and proliferation inhibiting effect on PC cells in vitro.

Patients And Methods: RT-PCR was used to detect the expression of SCCRO in PC tissue and corresponding adjacent normal tissues from 160 cases, and its relationship with clinical pathological characteristics was analyzed. Read More

Prostate 2017 Nov 6;77(15):1452-1467. Epub 2017 Sep 6.

Center for Cell Signaling, University of Virginia, Charlottesville, Virginia.

Background: Phosphoinositide-3 (PI-3) kinase signaling has a pervasive role in cancer. One of the key effectors of PI-3 kinase signaling is AKT, a kinase that promotes growth and survival in a variety of cancers. Genetically engineered mouse models of prostate cancer have shown that AKT signaling is sufficient to induce prostatic epithelial neoplasia (PIN), but insufficient for progression to adenocarcinoma. Read More

Int J Clin Exp Pathol 2017 1;10(8):8585-8591. Epub 2017 Aug 1.

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University Shenyang, China.

DCAF16 is a DDB1-CUL4 associated factor. The expression pattern of DCAF16 in human carcinomas is largely unknown. Here, we investigated DCAF16 expression in a series of human normal epithelial tissues and carcinomas using immunohistochemistry. Read More