1,160 results match your criteria Squamous Cell Carcinoma Eyelid


National incidence of eyelid cancer in Ireland (2005-2015).

Eye (Lond) 2019 Apr 11. Epub 2019 Apr 11.

Sligo University Hospital, Sligo, Ireland.

Aims: We report on the incidence of cutaneous eyelid tumours in Ireland over the 11-year-period from 2005 to 2015, we identify associations between demographic factors and cutaneous eyelid tumour risk.

Methods: Skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and other cancers, located on the eyelid or canthus according to ICD-10 coding, as registered by the National Cancer Registry of Ireland (NCRI), were captured from the period 2005 to 2015. Age standardised rates (ASR) were calculated according to the European Standard Population (2013). Read More

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http://www.nature.com/articles/s41433-019-0437-8
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http://dx.doi.org/10.1038/s41433-019-0437-8DOI Listing
April 2019
5 Reads

A missense mutation in damage-specific DNA binding protein 2 is a genetic risk factor for ocular squamous cell carcinoma in Belgian horses.

Equine Vet J 2019 Mar 23. Epub 2019 Mar 23.

Veterinary Medical Teaching Hospital, University of California-Davis, Davis, California, USA.

Background: Belgian horses are commonly affected with ocular squamous cell carcinoma (SCC), the most common cancer of the equine eye. A missense mutation in damage-specific DNA binding protein 2 (DDB2 c.1013C>T, p. Read More

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http://dx.doi.org/10.1111/evj.13116DOI Listing
March 2019
1 Read

Clinicopathologic Characteristics and Predictors Affecting Survival Outcome of Eyelid Malignancy.

J Craniofac Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

The aim of this study was to determine the clinicopathologic characteristics and evaluate the prognostic factors in eyelid malignancies. This was a retrospective, comparative, case series of 70 patients with eyelid malignancies. The mean age at diagnosis was 72. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005341DOI Listing
March 2019
1 Read

Validation Study of the AJCC Cancer Staging Manual, Eighth Edition, Staging System for Eyelid and Periocular Squamous Cell Carcinoma.

JAMA Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston.

Importance: To our knowledge, there are no validation studies to date of the prognostic value of the AJCC Cancer Staging Manual, eighth edition (AJCC 8), criteria for eyelid and periocular squamous cell carcinoma.

Objective: To determine the association of tumor (T) category in AJCC 8 with local recurrence, nodal metastasis, distant metastasis, and disease-specific survival (DSS) for eyelid and periocular squamous cell carcinoma.

Design, Setting, And Participants: In this retrospective, single-center cohort study, 109 consecutive patients with eyelid and periocular squamous cell carcinoma treated from January 1999 to April 2018 were included. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0238DOI Listing
March 2019
3 Reads

Treatment of squamous cell carcinoma of the eyelid with imiquimod 5% cream.

Can J Ophthalmol 2019 Feb 21;54(1):e24-e27. Epub 2018 May 21.

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1016/j.jcjo.2018.03.010DOI Listing
February 2019
1 Read

Dermoscopy for the diagnosis of eyelid margin tumours.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France.

There are only case reports concerning dermoscopy of eyelid margin tumours. We evaluated the clinical and dermoscopic features of 165 eyelid margin tumours of 145 consecutive patients (77 females, 68 males, mean age 64·3 years, standard deviation - SD 17·94, range 10 - 95 years) recruited at the Dermatology Department of the University Hospital of Saint-Etienne, France, between September 1st, 2013 and January 30th, 2017 to exclude malignant tumours. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17743
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http://dx.doi.org/10.1111/bjd.17743DOI Listing
February 2019
6 Reads

Facial distribution of squamous cell carcinoma in Japanese.

Exp Dermatol 2019 Feb;28 Suppl 1:72-74

Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Squamous cell carcinoma (SCC) is a malignant tumor of the skin. SCC is frequently distributed on highly exposed areas such as the face and dorsal surface of the hands because it is closely related to ultraviolet damage. We retrospectively analyzed 106 cases of SCC treated at Nagoya City University Hospital from April 2004 to October 2015 and examined regional features based on modified facial aesthetic units. Read More

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http://dx.doi.org/10.1111/exd.13830DOI Listing
February 2019
11 Reads

The Amazon Ocular Oncology Center: The first three years.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

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http://dx.doi.org/10.5935/0004-2749.20190024DOI Listing
January 2019
1 Read

HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 21;257(4):785-790. Epub 2019 Jan 21.

Save Sight Institute, University of Sydney, Sydney Eye Hospital Campus, 8 Macquarie Street, Sydney, NSW, 2000, Australia.

Purpose: 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of cholesterol production, has been found to contribute to lipid secretion from skin sebaceous glands and hair follicles. We assessed for HMGCR expression in human eyelid tissue and in immortalized human meibomian gland epithelial cells (HMGECs) using immunohistochemistry.

Methods: Full thickness human eyelid specimens in archival paraffin blocks were obtained. Read More

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http://dx.doi.org/10.1007/s00417-019-04247-9DOI Listing
April 2019
15 Reads

Squamous cell carcinoma with clear cell differentiation in an equine eyelid.

J Vet Diagn Invest 2019 Mar 19;31(2):259-262. Epub 2019 Jan 19.

Michigan State University Veterinary Diagnostic Laboratory.

A 15-y-old Miniature horse mare had a 6-mo history of an ulcerated mass on the right lower eyelid. An incisional biopsy and a subsequent excisional biopsy were submitted to the Michigan State University Veterinary Diagnostic Laboratory for microscopic evaluation. Histologically, the incisional biopsy was composed of sheets of large neoplastic vacuolated polygonal cells. Read More

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http://dx.doi.org/10.1177/1040638718824377DOI Listing

Rhomboid blepharoplasty and cryotherapy for the treatment of a squamous cell carcinoma on the lower eyelid in a horse.

Clin Case Rep 2019 Jan 11;7(1):40-46. Epub 2018 Nov 11.

Queen Mother Hospital for Animals Royal Veterinary College North Mymms, Hertfordshire UK.

A rhomboid blepharoplasty can be used to achieve functional and cosmetic eyelid reconstruction at the medial canthus in the horse. Combination of a rhomboid blepharoplasty with cryotherapy is a treatment option for eyelid ocular squamous cell carcinomas. Read More

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http://dx.doi.org/10.1002/ccr3.1907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333075PMC
January 2019

Conjuctival lesions - the relationship of papillomas and squamous cell carcinoma to HPV infection.

Cesk Slov Oftalmol Winter 2018;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

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http://www.cs-ophthalmology.cz/en/journal/2018/3/2
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http://dx.doi.org/10.31348/2018/1/2-3-2018DOI Listing
January 2019
9 Reads

Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature.

World J Clin Cases 2018 Dec;6(16):1194-1198

Departments of Radiation Oncology, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, South Korea.

Background: Primary sebaceous carcinoma of lacrimal gland (SCLG) is extremely rare. Due to its clinical characteristics, it is often misdiagnosed. It is known to be aggressive so delay in diagnosis can increase the chance of local recurrence and metastasis. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i16.1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306633PMC
December 2018
3 Reads

[Metastases of cervical cancer to the nasal cavity and paranasal sinus with maxillofacial symptoms: a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1832-1833

A 41 year old female complained of left eyelid, cheek and face erythema, swelling with pain for 7 days. She was diagnosed with cervical squamous cell carcinoma, stage ⅢA a year ago. The anterior rhinoscopy examination showed that the dry scab adheres to the left nasal cavity, and a small amount of reddish mass were found, and the touch was brittle. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.23.016DOI Listing
December 2018
1 Read

Recurrence of periocular basal cell carcinoma and squamous cell carcinoma after Mohs micrographic surgery: a retrospective cohort study.

Br J Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Erasmus MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.

Background: Despite the widespread use of Mohs micrographic surgery (MMS) for periocular basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) - together called keratinocyte carcinoma (KC) - follow-up data regarding recurrences are limited.

Objectives: To investigate the recurrence rate for periocular KCs after MMS and to describe our experience with interdisciplinary collaborations.

Methods: Patients with periocular KCs treated with MMS between 2006 and 2016 in a tertiary MMS referral hospital were included in this retrospective cohort study. Read More

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http://dx.doi.org/10.1111/bjd.17516DOI Listing
December 2018
1 Read

Malignant eyelid tumors: Are intra-operative rapid frozen section and permanent section diagnoses of surgical margins concordant?

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Ophthalmic Pathology Laboratory (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors.

Methods: This is a retrospective study of 120 cases and 429 frozen section slides.

Results: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. Read More

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http://dx.doi.org/10.1007/s10792-018-1058-0DOI Listing
December 2018
4 Reads

[Use of the autologous dorsal dermis in reconstruction of the posterior palpebral lamella in blepharopoiesis].

Ann Chir Plast Esthet 2019 Feb 30;64(1):44-53. Epub 2018 Nov 30.

Département de chirurgie plastique, reconstructrice, brûlés, plaies et cicatrisation, CHU Lapeyronie, 371, avenue de Doyen Gaston Giraud, 34295 Montpellier, France. Electronic address:

Objectives: Blepharopoiesis represents a double aesthetic and functional challenge. If anterior lamellar reconstruction is less discussed, the variety of posterior lamellar substitutes testifies that none is ideal. We report here our experience of the use of autologous dermal dermis as posterior lamellar substitutes in bilamellar blepharopoiesis. Read More

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http://dx.doi.org/10.1016/j.anplas.2018.07.006DOI Listing
February 2019
4 Reads

A retrospective study of 2228 cases with eyelid tumors.

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.11.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232338PMC
November 2018
17 Reads

Isolated Horner syndrome as a rare initial presentation of nasopharyngeal carcinoma: a case report.

Int Med Case Rep J 2018 18;11:271-276. Epub 2018 Oct 18.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand,

Background: Horner syndrome refers to a set of clinical presentations resulting from disruption of sympathetic innervation to the eye and adnexa. Classically, the clinical triad consists of ipsilateral blepharoptosis, pupillary miosis, and facial anhidrosis. Ocular sympathetic denervation may signify life-threatening causes. Read More

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https://www.dovepress.com/isolated-horner-syndrome-as-a-rare
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http://dx.doi.org/10.2147/IMCRJ.S177337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202048PMC
October 2018
11 Reads

[Tarsal conjunctiva: an exceptional localization of squamous cell carcinoma of the conjunctiva].

Pan Afr Med J 2018 19;30:139. Epub 2018 Jun 19.

Faculté de Médecine et de Pharmacie de Fès, CHU Hassan II, Fès, Maroc.

We here report the case of a 48-year old patient with a family history of five deaths due to cancers with different localizations, presenting with ulcero-budding nodular swelling of the lower palpebral conjunctiva measuring 2cm long its longer axis, gradually increasing volume over one year. It involved the inner half of the lower tarsal conjunctiva closely with the lower lacrimal punctum (A). Tumor biopsy showed well differentiated squamous carcinoma of the conjunctiva. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.139.11216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201600PMC
November 2018
1 Read

Primary limbal stem cell transplantation in the surgical management of extensive ocular surface squamous neoplasia involving the limbus.

Indian J Ophthalmol 2018 Nov;66(11):1569-1573

Oculoplasty, Orbit and Ocular Oncology Services, Centre for Sight, Hyderabad, Telangana, India.

Purpose: To determine the role of primary limbal stem cell transplantation (LSCT) in managing extensive ocular surface squamous neoplasia (OSSN) with more than 3 quadrants of limbal involvement to prevent manifestations of limbal stem cell deficiency.

Methods: A multi-center, comparative, and interventional clinical study of cases and historical controls was done. Patients with a limbal mass suggestive of OSSN involving more than 3 quadrants of limbus (> 9 clock hours) and no local, regional or systemic metastasis, who underwent primary surgical excision with or without adjuvant chemotherapy and had a minimum follow-up of 12 months were included in this study. Read More

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http://www.ijo.in/text.asp?2018/66/11/1569/244052
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http://dx.doi.org/10.4103/ijo.IJO_348_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213701PMC
November 2018
1 Read

Ocular and Periocular Tumors in Xeroderma Pigmentosum: A Study of 120 Asian Indian Patients.

Am J Ophthalmol 2019 Feb 16;198:146-153. Epub 2018 Oct 16.

Ophthalmic Pathology Laboratory, L. V. Prasad Eye Institute, Hyderabad, India.

Purpose: We studied the incidence, treatment, and outcome of ocular and periocular tumors in patients with xeroderma pigmentosum (XP).

Design: Retrospective case series.

Methods: This single-institution study included 120 patients with XP who underwent intervention with excisional biopsy, enucleation, or orbital exenteration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183059
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http://dx.doi.org/10.1016/j.ajo.2018.10.011DOI Listing
February 2019
25 Reads

Clinical-pathological characteristics of patients treated for cancers of the eyelid skin and periocular areas.

Adv Clin Exp Med 2019 Mar;28(3):325-330

Department of Maxillofacial Surgery, Frederic Chopin Clinical Hospital No. 1 in Rzeszów, Poland.

Background: Malignant cancers of the eyelid skin and the periocular area comprise 5-10% of facial skin malignant cancers. Basal cell carcinomas (BCCs) dominate, comprising approx. 80-90% of cancers of this area of the face. Read More

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http://dx.doi.org/10.17219/acem/78023DOI Listing
March 2019
3 Reads

Review of outcomes of 500 consecutive cases of non-melanoma skin cancer of the head and neck managed in an oral and maxillofacial surgical unit in a District General Hospital.

Br J Oral Maxillofac Surg 2018 11 13;56(9):805-809. Epub 2018 Sep 13.

Oral & Maxillofacial Surgery department at Mugrove Park Hospital, Taunton and Somerset NHSFT, Parkfield drive, Taunton, TA15DA. Electronic address:

We provide a non-melanoma skin cancer (NMSC) service for skin cancers of the head and neck in the south-west of England. We hypothesised that certain anatomical sites such as the nose and eyelid would have a higher incidence of close or involved margins than others, and that the choice of repair might influence the excised margins. We therefore retrospectively analysed the data of 500 consecutive NMSC that were operated on in the oral and maxillofacial surgery unit of Taunton and Somerset NHS Trust. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02664356183028
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http://dx.doi.org/10.1016/j.bjoms.2018.08.015DOI Listing
November 2018
7 Reads

Cancers of the eye.

Cancer Metastasis Rev 2018 12;37(4):677-690

The New York Eye Cancer Center, Suite 5B, 115 East 61st Street, New York, NY, 10065, USA.

Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Read More

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http://link.springer.com/10.1007/s10555-018-9762-9
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http://dx.doi.org/10.1007/s10555-018-9762-9DOI Listing
December 2018
24 Reads

Characteristics, management, and outcome of squamous carcinoma of the conjunctiva in a single tertiary cancer center in Jordan.

Int J Ophthalmol 2018 18;11(7):1132-1138. Epub 2018 Jul 18.

Department of Surgery (Ophthalmology), King Hussein Cancer Centre (KHCC), Amman 11941, Jordan.

Aim: To evaluate the features and outcome of management of malignant conjunctival squamous tumors in King Hussein Cancer Center (a referral tertiary cancer center in the Middle East).

Methods: Retrospective case series of 31 eyes for 31 patients with conjunctival squamous neoplasia. Main outcome measures included: age, gender, laterality, tumor location, pathological features, tumor stage, treatment modality, and outcome. Read More

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http://dx.doi.org/10.18240/ijo.2018.07.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048346PMC
July 2018
7 Reads

Genetic risk for squamous cell carcinoma of the nictitating membrane parallels that of the limbus in Haflinger horses.

Anim Genet 2018 Oct 12;49(5):457-460. Epub 2018 Jul 12.

Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.

Squamous cell carcinoma (SCC) is the most common cancer affecting the equine eye, with a higher incidence documented in Haflinger horses. Recently, a missense variant in the gene damage specific DNA binding protein 2 (DDB2, p.Thr338Met) on ECA12 was identified as a risk factor for the development of limbal SCC in Haflinger horses. Read More

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http://dx.doi.org/10.1111/age.12695DOI Listing
October 2018
6 Reads

Management of a Lower Eyelid Defect.

Dermatol Surg 2018 12;44(12):1627-1630

Division of Dermatology, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1097/DSS.0000000000001596DOI Listing
December 2018

Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling.

Br J Ophthalmol 2018 Jun 28. Epub 2018 Jun 28.

Department of Histopathology, National Specialist Ophthalmic Pathology Service (NSOPS), Royal Hallamshire Hospital, Sheffield, UK.

Purpose: To present the clinical and histological features of squamous cell carcinoma (SCC) in the anophthalmic socket in four adult patients, and to determine the presence of human papillomavirus infection (HPV).

Methods: Retrospective case series of four adult patients with SCC of the anophthalmic socket. P16 immunohistochemistry and HPV testing was carried out in all cases. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-311916DOI Listing
June 2018
12 Reads

The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, U.K.

Br J Dermatol 2018 Oct 5;179(4):824-828. Epub 2018 Sep 5.

Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, U.K.

The 8th edition of TNM (tumour, node and metastasis) has numerous and important changes compared with the 7th edition. Public Health England and the Royal College of Pathologists, U.K. Read More

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http://dx.doi.org/10.1111/bjd.16892DOI Listing
October 2018
2 Reads

Stable Upper Eyelid after 2 Successive Tarsoconjunctival Flaps.

Plast Reconstr Surg Glob Open 2018 May 14;6(5):e1724. Epub 2018 May 14.

Department of Ophthalmology, University of Illinois at Chicago, Chicago, Ill.

A 70-year-old male with history of multiple cutaneous squamous cell carcinoma throughout the body presented with a left lower lid margin squamous cell carcinoma. The lesion was excised via Mohs surgery elsewhere, and the defect was reconstructed with a tarsoconjunctival flap (Hughes flap). The lesion recurred, and the patient had a second Mohs surgery for excision. Read More

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http://dx.doi.org/10.1097/GOX.0000000000001724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999439PMC
May 2018
3 Reads

Change in Eyelid Carcinoma T Category With Use of the 8th Versus 7th Edition of the American Joint Committee on Cancer: Cancer Staging Manual.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):38-41

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery.

Purpose: To evaluate the frequency and nature of changes in T category when eyelid carcinomas are staged using the criteria in the 8th edition instead of the 7th edition of the American Joint Committee on Cancer staging manual.

Methods: Following Institutional Review Board approval, a retrospective review was conducted for all consecutive patients with the diagnosis of eyelid carcinoma treated by the senior author from January 2012 through December 2016. After a review of the clinical and pathologic data, each patient's disease was staged using both the 7th-edition and 8th-edition American Joint Committee on Cancer criteria for eyelid carcinomas. Read More

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http://Insights.ovid.com/crossref?an=00002341-900000000-9849
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http://dx.doi.org/10.1097/IOP.0000000000001133DOI Listing
June 2018
9 Reads

Outcomes after surgical resection of lower eyelid tumors and reconstruction using a nasal chondromucosal graft and an upper eyelid myocutaneous flap.

J Fr Ophtalmol 2018 May 16;41(5):412-420. Epub 2018 May 16.

Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.

Introduction: Surgical excision of large malignant lower eyelid tumors may cause important full-thickness eyelid defects. The reconstruction of such defects must restore the physiologic function of the eyelid and also re-establish an acceptable aesthetic result.

Materials And Methods: We report the outcomes of full-thickness excision of tumors extending over half of the horizontal lid length, followed by reconstruction using a nasal chondromucosal graft (coming from the ipsilateral ala of the nose) and an upper eyelid myocutaneous flap. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.10.008DOI Listing
May 2018
5 Reads

MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma.

Sci Rep 2018 May 14;8(1):7531. Epub 2018 May 14.

Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK.

Sebaceous gland carcinoma (SGC) is a rare, but life-threatening condition with a predilection for the periocular region. Eyelid SGC can be broadly categorised into two subtypes, namely either nodular or pagetoid with the latter being more aggressive and requiring radical excision to save life. We have identified key altered microRNAs (miRNA) involved in SGC shared by both subtypes, hsa-miR-34a-5p and hsa-miR-16-5p. Read More

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http://dx.doi.org/10.1038/s41598-018-25900-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951834PMC
May 2018
11 Reads

Posterior Lamellar Reconstruction of the Lower Eyelid With a Gingivoalveolar Mucosal Graft.

Authors:
Yahya Baltu

J Craniofac Surg 2018 Jun;29(4):1017-1019

Department of Plastic Reconstructive and Aesthetic Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

The anterior and posterior lamellae should be simultaneously reconstructed to repair the upper and lower eyelid's full thickness defects after resection of a malignant tumor. The author described a gingivoalveolar mucosal graft for posterior lamellar reconstruction of the lower eyelid. Between November 2014 and September 2017, 11 patients (6 women, 5 men; mean age 62. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004432DOI Listing
June 2018
13 Reads

Ocular sebaceous gland carcinoma: an update of the literature.

Int Ophthalmol 2018 Apr 25. Epub 2018 Apr 25.

The Operation Eyesight, Universal Institute for Eye Cancer (MVC, SK), L V Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment.

Methods: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. Read More

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http://dx.doi.org/10.1007/s10792-018-0925-zDOI Listing
April 2018
3 Reads

Primary basosquamous carcinoma of the lower eyelid with ocular invasion A case report.

Ann Ital Chir 2018 Mar 26;7. Epub 2018 Mar 26.

Introduction: Ocular invasion is extremely rare for a primary eyelid Basosquamous Carcinoma (BSC). It can however occur in neglected cases if the clinical signs are overseen and the BSC is misdiagnosed for a less aggressive skin carcinoma.

Materials And Methods: A 58-year-old man suffering from an inferior eyelid BSC that had been neglected for 7 years was referred to our clinic. Read More

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March 2018
15 Reads

Largest case series of Latin American eyelid tumors over 13-Years from a single center in Sao Paulo, Brazil.

Arq Bras Oftalmol 2018 Jan-Feb;81(1):7-11

Department of Ophthalmology and Visual Sciences, Ocular Oncology Service, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: Malignant lesions of the eyelid are the most common eye cancers. Although rarely lethal, late diagnosis can lead to serious visual morbidity. Definitive diagnosis of neoplastic lesions is pathological. Read More

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http://dx.doi.org/10.5935/0004-2749.20180004DOI Listing
October 2018
8 Reads

Peri - and Intraocular Mutilating Advanced Squamous Cell Carcinoma: "Monsters Inside Your Body"?

Open Access Maced J Med Sci 2018 Jan 13;6(1):132-133. Epub 2018 Jan 13.

Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen, Germany.

Periocular malignancies represent between 5% and 10% of all types of skin cancers. The incidence of eyelid (but also the periocular located) malignancies seems to differ in distribution across the continents. The incidence of eyelid tumours (but also the periocular located tumours) in a predominantly white population determined that BCC is the most common malignant periocular eyelid tumour in whites. Read More

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http://dx.doi.org/10.3889/oamjms.2018.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816283PMC
January 2018
2 Reads

Primary squamous cell carcinoma arising from palpebral conjunctiva: A rare presentation.

Indian J Ophthalmol 2018 Feb;66(2):304-306

Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Squamous cell carcinoma (SCC) of the conjunctiva usually arises from the limbal conjunctiva. Rarely, it can arise from the palpebral conjunctiva. We report a case of primary conjunctival SCC of the palpebral conjunctiva which was treated successfully. Read More

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http://dx.doi.org/10.4103/ijo.IJO_754_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819124PMC
February 2018
2 Reads

Monocle tumor as tonsillar squamous cell carcinoma metastasis: resolution after chemotherapy treatment.

Int J Dermatol 2018 04 25;57(4):498-500. Epub 2018 Jan 25.

Department of Oncology, Hospital Universitari General de Catalunya, Sant Cugat del Vàlles, Barcelona, Spain.

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http://doi.wiley.com/10.1111/ijd.13917
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http://dx.doi.org/10.1111/ijd.13917DOI Listing
April 2018
6 Reads

Report on the incidence of squamous cell carcinomas affecting the eyelids in England over a 15-year period (2000-2014).

Br J Ophthalmol 2018 10 23;102(10):1358-1361. Epub 2018 Jan 23.

NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, Moorfields Eye Hospital, London, UK.

Aims: The authors report on trends in the incidence of squamous cell carcinoma (SCC) affecting the eyelids in England over a 15-year period and identify associations between demographic factors and SCC risk.

Methods: The National Cancer Registration and Analysis Service identified all cases of eyelid SCC in England between 2000 and 2014. The crude and age-standardised rates of eyelid SCCs in England were calculated. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2017-310956DOI Listing
October 2018
9 Reads

Reversible cicatricial ectropion associated with EGFR inhibitors.

Orbit 2018 Oct 16;37(5):364-367. Epub 2018 Jan 16.

a Department of Ophthalmology , Columbia University Medical Center , New York , New York , USA.

The management of cicatricial ectropion resulting from epidermal growth factor receptor (EGFR) inhibitors is unclear. We describe two cases of bilateral cicatricial ectropion following the use of an EGFR inhibitor who were treated with oral doxycycline, topical ophthalmic steroid and antibiotic ointment to the eyelids, and topical facial steroid cream with lubrication. The first case resolved with discontinuation of panitumumab infusions along with institution of the aforementioned regimen. Read More

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https://www.tandfonline.com/doi/full/10.1080/01676830.2017.1
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http://dx.doi.org/10.1080/01676830.2017.1423342DOI Listing
October 2018
2 Reads

Reconstruction of extensive medial canthal defects using a single V-Y, island pedicle flap.

Orbit 2018 Oct 15;37(5):331-334. Epub 2018 Jan 15.

a Oxford Eye Hospital , John Radcliffe Hospital , Headington , UK.

The medial canthus represents one of the most challenging regions of the face to reconstruct due to the anatomical structures present, the concavity of the area, and the differences in skin texture. We present a case series of 11 patients whose defects were reconstructed with a single V-Y island pedicle flap running along the nasofacial sulcus. Our single-stage flap which modified and simplified a previously described technique achieves similar cosmetic and postoperative outcomes along with a high level of patient satisfaction in an area which can be reconstructed in a variety of ways, often with suboptimal results. Read More

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http://dx.doi.org/10.1080/01676830.2017.1423344DOI Listing
October 2018
3 Reads

Modified second stage Hughes tarsoconjunctival reconstruction for lower eyelid defects.

Orbit 2018 Oct 15;37(5):335-340. Epub 2018 Jan 15.

a Department of Ophthalmology , University of Virginia , Charlottesville , Virginia , USA.

To describe a novel technique utilizing an amniotic membrane graft (AMT) to create the mucocutaneous portion of the lower eyelid margin in a modified Hughes eyelid reconstruction for secondary revision or prevention of a hyperemic, hypertrophic conjunctival margin with excessive discharge. This was a retrospective, non-comparative interventional study. Thirty consecutive patients who underwent a modified Hughes reconstruction were included. Read More

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http://dx.doi.org/10.1080/01676830.2017.1423351DOI Listing
October 2018
9 Reads

Superiorly based nasolabial island flap for reconstruction of the lateral lower eyelid

Turk J Med Sci 2017 Dec 19;47(6):1673-1680. Epub 2017 Dec 19.

Background/aim: Various flap procedures have been described and used for the lower eyelids; however, the nasolabial flap is rarely employed. We herein aimed to present the clinical results of using the superiorly based nasolabial island flap for repair of surgical defects extending to the lateral lower eyelid. Materials and methods: Nine patients with a mean age of 62 +- 6 years underwent surgery for reconstruction of the lower eyelid. Read More

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http://dx.doi.org/10.3906/sag-1701-160DOI Listing
December 2017
7 Reads

Intratarsal keratinous eyelid cysts in Gorlin syndrome: A review and reappraisal.

Surv Ophthalmol 2018 Sep - Oct;63(5):711-718. Epub 2017 Dec 27.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

A 38-year-old woman presented with multiple bilateral recurrent eyelid cysts. Her medical history was notable for Gorlin (nevoid basal cell carcinoma) syndrome. Histopathologic and immunohistochemical examinations revealed that the lesions were intratarsal keratinous cysts. Read More

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http://dx.doi.org/10.1016/j.survophthal.2017.12.007DOI Listing
September 2018
11 Reads

Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?

Indian J Ophthalmol 2018 01;66(1):55-60

Department of Ocular Tumor and Orbital Disease, The New York Eye Cancer Center; Department of Ophthalmology, The New York Eye and Ear Infirmary of Mt. Sinai, New York, NY, USA.

Purpose: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN).

Methods: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications. Read More

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http://dx.doi.org/10.4103/ijo.IJO_590_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778583PMC
January 2018
18 Reads

Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam™ of expert clinicians.

J Eur Acad Dermatol Venereol 2018 Mar 15;32(3):339-346. Epub 2018 Jan 15.

Department of Dermato cancerology, University Hospital Hotel Dieu, Nantes, France.

Actinic keratoses (AK) arise on sun-exposed regions of the skin. If left untreated, AK may progress to invasive squamous cell carcinoma (SCC), although the rate of progression is low. A practical treatment algorithm for the treatment of AK in standard situations has been published by the AKTeam expert panel. Read More

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http://doi.wiley.com/10.1111/jdv.14753
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http://dx.doi.org/10.1111/jdv.14753DOI Listing
March 2018
16 Reads