1,265 results match your criteria Squamous Cell Carcinoma Eyelid

Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy.

Ocul Oncol Pathol 2021 Mar 2;7(2):149-158. Epub 2020 Dec 2.

The MUHC, McGill University Ocular Pathology and Translational Research Laboratory, McGill University, Montreal, Québec, Canada.

Introduction: Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. Read More

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Clinical and pathological risk factors for worse stage and mortality of eyelid and periocular squamous cell carcinoma.

Br J Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

Background: The clinical and pathological risk factors for worse T stage and prognosis in eyelid and periocular squamous cell carcinomas (SCCs) remain unclear. P63 was reported to predict a worse prognosis in other SCCs; however, this correlation was not validated in eyelid and periocular SCCs.

Methods: We reported on a retrospective case series of 85 consecutive patients with eyelid and periocular SCCs from 1995 to 2019. Read More

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Epidemiological Profile and Clinical Stage at Presentation of Eyelid Malignancies in a Multi-Ethnic Country.

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Ophthalmology and Visual Sciences, Division of Ophthalmic Plastic and Reconstructive Surgery, Paulista School of Medicine - EPM, Federal University of S. Paulo - UNIFESP, Sao Paulo, Brazil.

Abstract: Eyelid malignancies are frequently seen in clinical practice. There is a lack of studies that have assessed the features of these lesions in mixed population countries. The epidemiologic profile, clinical stage at presentation, management, and outcomes of patients with eyelid malignancies were assessed, in order to better understand the features of these lesions in a multi-ethnic country. Read More

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Cytological Evaluation of Palpebral Lesions: An Insight into its Limitations Aided with Histopathological Corroboration.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):12-17. Epub 2020 Nov 9.

Department of Pathology, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.

Context: Eyelids by virtue of its unique histomorphology give rise to multitudes of different pathological conditions. Appropriate preoperative cytological diagnoses of these cases are necessary to determine their optimal therapy.

Aims: The aims of this study were to evaluate the utility of various cytological techniques in diagnosing the definite pathology for palpebral lesions and thereby to highlight the drawbacks associated with cytology in this context. Read More

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November 2020

Successful treatment of upper-left eyelid squamous cell carcinoma in an epidermodysplasia verruciformis patient by ALA-PDT / holmium laser combination therapy.

Photodiagnosis Photodyn Ther 2021 Apr 2:102277. Epub 2021 Apr 2.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disorder. Individuals with EV are more susceptible to the development of cutaneous neoplasia in sun-exposed regions. This disease should be closely observed for cutaneous squamous cell carcinoma (cSCC) or pre-cancerous lesions - if neoplasia is found, it should be removed. Read More

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Osseointegrated Implants for Orbito-Facial Prostheses: Common Complications and Solutions.

J Craniofac Surg 2021 Mar 12. Epub 2021 Mar 12.

Sisli Hamidiye Etfal Training and Research Hospital, Istanbul Bursa Retina Eye Hospital Medicabil Hospital, Bursa, Turkey.

Purpose: To evaluate anatomical and functional results of osseointegration with magnetic coupling for oculofacial prosthetic rehabilitation after exenteration.

Methods: This retrospective study included 11 consecutive patients who received orbital reconstruction and oculofacial prosthetic rehabilitation between September 2015 and October 2019. Patient demographics, surgical indications, previous treatment procedures, histopathologic features, and reconstructive procedures were recorded. Read More

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Total orbital exenteration with temporalis muscle transfer and secondary healing.

Can J Ophthalmol 2021 Mar 11. Epub 2021 Mar 11.

Institut Curie, Service d'oncologie oculaire, Paris, France.

Objective: To evaluate the outcomes of orbital exenteration with temporalis muscle flap repair of the socket and secondary healing of the anterior surface of the flap in ocular, conjunctival, and eyelid malignancies.

Design: Retrospective single-centre study.

Participants: Consecutive patients who underwent total exenteration for malignancy with temporal muscle flap repair of the socket between December 2009 and January 2016. Read More

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Epidemiological characteristics and clinical course of eyelid squamous cell carcinoma patients from a large tertiary centre between 2009 and 2020.

Br J Ophthalmol 2021 Mar 12. Epub 2021 Mar 12.

Department of Ophthalmology, Ludwig-Maximilians-University Munich, Munich, Bavaria, Germany.

Background/aims: To assess epidemiological tumour features, risk factors, clinical management and outcome of eyelid squamous cell carcinoma (SCC) and changes thereof. Furthermore, we searched for validating predictors of the American Joint Committee on Cancer (AJCC) 8 classification system.

Methods: We evaluated data of 117 patients with histologically proven eyelid SCC at a large tertiary German university centre between January 2009 and March 2020. Read More

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Management of periocular cutaneous squamous cell carcinoma with perineural invasion: a case series and literature review.

Orbit 2021 Mar 4:1-10. Epub 2021 Mar 4.

Orbital and Oculofacial Plastic Surgery, Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

: To review and elucidate the complex, multimodal management of periocular cutaneous squamous cell carcinoma (SCC) with perineural invasion (PNI), and offer practical, evidence-based patient care recommendations. Three exemplary cases of high-risk periocular cutaneous SCC with PNI were selected from a single surgeon's experience. The clinical courses, management, and clinical outcomes, with follow-up intervals of 19, 19, and 24 months after presentation, were reviewed. Read More

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Adenocarcinoma NOS arising from accessory lacrimal glands: A case report and a review of the literature.

Eur J Ophthalmol 2021 Mar 4:1120672121999993. Epub 2021 Mar 4.

Istituto di Patologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Primary malignant epithelial tumours arising from accessory lacrimal glands (ALGs) are extremely rare, with only few cases reported in literature. They generally appear as gradually increasing masses of the upper or the lower eyelid. Only one case of primary adenocarcinoma or adenocarcinoma not otherwise specified (ACNOS) from ALGs has been reported in literature. Read More

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Combination of squamous cell carcinoma and basal cell carcinoma arising from a giant verruca vulgaris involving the eyelid.

Am J Ophthalmol Case Rep 2021 Mar 5;21:100858. Epub 2020 Aug 5.

Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong.

Purpose: Verruca Vulgaris is a common benign cutaneous lesion which only reported occasionally to have malignant potential. Our purpose is to report a rare case of verruca vulgaris involving the eyelid and subsequently transformed into the combination of squamous cell carcinoma and basal cell carcinoma.

Observations: We reported a case of a 97-year-old female with a chronic biopsy proven verruca vulgaris involving the left lateral canthus. Read More

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An Unusual Case of Perineural Infiltration and Orbital Invasion of Squamous Cell Carcinoma Associated with Actinic Keratosis.

Case Rep Ophthalmol Med 2020 30;2020:8831668. Epub 2020 Dec 30.

Fondation Ophtalmologique Adolphe de Rotschild, 29 Rue Manin, 75019 Paris, France.

Actinic keratosis is considered a precancerous lesion, constituting a precursor to squamous cell carcinoma (SCC) formation. Perineural invasion has been observed in patients with cutaneous carcinoma due to local subcutaneous tissue destruction and primarily involves the trigeminal nerve due to rich innervation provided by the supraorbital nerve in addition to the facial nerve. An unusual case of perineural infiltration and orbital invasion of squamous cell carcinoma associated with actinic keratosis is presented. Read More

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December 2020

Exenteration and Adjuvant Radiotherapy for Primary Carcinosarcoma of the Anterior Orbit: A Case Report.

Ophthalmic Plast Reconstr Surg 2021 Jan 19. Epub 2021 Jan 19.

Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Oculoplastics, Wills Eye Hospital, Philadelphia, Pennsylvania Department of Ocular Pathology, Wills Eye Hospital, Philadelphia, Pennsylvania.

Carcinosarcoma is a malignant mixed tumor composed of epithelial and mesenchymal components which arises in a variety of tissues, including, in rare cases, the orbit. A 75-year-old male with a history of basal cell carcinoma of the left medial canthus, previously treated with surgical resection and adjuvant radiation therapy, presented with a recurrent 3 cm nodule of the left medial canthus. He underwent surgical resection of the left superior and inferior eyelid with pathology revealing invasive squamous cell carcinoma of upper and lower eyelids with deep orbital tissue involvement and undifferentiated pleomorphic sarcoma involving the dermis and periosteum, consistent with carcinosarcoma. Read More

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January 2021

Eyelid carcinoma: An experience from a tertiary cancer center.

J Cancer Res Ther 2020 Dec;16(Supplement):S48-S52

Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.

Context: Eyelid carcinoma is rare tumors of the head and neck. They are rarely lethal but can be associated with significant morbidity if not treated early and appropriately. There are limited data available from world over and in particular the Indian subcontinent regarding eyelid carcinoma and its prognostic factors influencing treatment outcomes. Read More

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December 2020

Cervicofacial flap for reconstruction of squamous cell carcinoma on the right cheek: A case report.

Shogo Ebisudani

Clin Case Rep 2020 Dec 30;8(12):3204-3207. Epub 2020 Sep 30.

Department of Plastic and Reconstructive Surgery Kawasaki Medical School Kurashiki Japan.

Reconstruction of the cheek to the lower eyelid can be performed with the use of a cervicofacial flap in patients that may not otherwise be able to sustain a long surgical procedure. In addition, the cervicofacial flap is superior in terms of color and texture match. Read More

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December 2020

Vertical Lid Split to Aid Excision and Reconstruction of Conjunctival Tumors Involving the Fornices.

Ophthalmic Plast Reconstr Surg 2020 Dec 9. Epub 2020 Dec 9.

Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.

Purpose: To describe how a vertical lid split helps excision and reconstruction of conjunctival tumors.

Methods: All patients with a limited view of conjunctival tumors involving the fornices underwent a vertical lid split procedure to improve access during resection and reconstruction.

Results: There were 11 cases where vertical lid splits were performed to assist excision and reconstruction of conjunctival tumors on patients between 2015 and 2019. Read More

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December 2020

Analysis of Tumour Related Data and Clinical Features of Eyelid Carcinomas.

Curr Health Sci J 2020 Jul-Sep;46(3):222-229. Epub 2020 Sep 30.

Department of Plastic Surgery, University of Medicine and Pharmacy of Craiova, Romania.

Almost 10% of worldwide skin cancers are located at the eyelid level. In European countries, malign eyelid tumours are mostly represented by basal and squamous cell carcinomas, and usually affect elderly patients. In order to study the clinical features of eyelid tumours, and potential correlations between tumour parameters, we have enrolled a cohort of 98 subjects from a south-western region of Romania. Read More

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September 2020

A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma.

DNA Repair (Amst) 2021 Jan 12;97:103022. Epub 2020 Nov 12.

Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.

Squamous cell carcinoma (SCC) occurs frequently in the human Xeroderma Pigmentosum (XP) syndrome and is characterized by deficient UV-damage repair. SCC is the most common equine ocular cancer and the only associated genetic risk factor is a UV-damage repair protein. Specifically, a missense mutation in horse DDB2 (T338M) was strongly associated with both limbal SCC and third eyelid SCC in three breeds of horses (Halflinger, Belgian, and Rocky Mountain Horses) and was hypothesized to impair binding to UV-damaged DNA. Read More

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January 2021

A Case of Giant Proliferative Periocular Pyogenic Granuloma.

Orbit 2020 Nov 12:1-2. Epub 2020 Nov 12.

Department of Plastic Surgery, Queen Elizabeth Hospital, Birmingham, UK.

Pyogenic granuloma (PG) is a common vascular anomaly affecting the skin with occasional involvement of mucosa. Ophthalmic surgeons typically encounter these lesions as solitary, bright red, rapidly growing papules following surgery or trauma to the conjunctiva, e.g. Read More

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November 2020

Malignant tumors of the eyelid in India: A multicenter, multizone study on clinicopathologic features and outcomes.

Indian J Ophthalmol 2020 Nov;68(11):2466-2470

Department of Orbit, Oculoplasty and Ocular Oncology, Center for Sight, New Delhi, India.

Purpose: To analyze data on eyelid malignancy in India, clinical and pathologic features, and outcomes.

Methods: A multicentre study, from oculoplastic practices in four geographic zones in India. The centers perform similar documentation and protocol-based management for eyelid tumors. Read More

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November 2020

Malignant tumors of the eyelid - To err is human, to learn divine.

Indian J Ophthalmol 2020 11;68(11):2333-2334

Editor, Indian Journal of Ophthalmology, Editorial Office: Centre for Sight, Road No 2, Banjara Hills, Hyderabad, Telangana, India.

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November 2020

Transcriptomic analysis of eyelid pigmentation in Hereford cattle.

Anim Genet 2020 Dec 15;51(6):935-939. Epub 2020 Oct 15.

Departamento de Genética y Mejora Animal, Facultad de Veterinaria, Universidad de la República, Montevideo, 11600, Uruguay.

The study of skin color in cattle holds both economic and scientific interest. Several ocular diseases of cattle have been associated with low pigmentation of the eyelids, including ocular squamous cell carcinoma and infectious keratoconjunctivitis, the two most common ocular diseases affecting cattle production. Although low eyelid pigmentation is a well-known risk factor for various ocular diseases, the genetic and biological basis of this relationship is largely unknown. Read More

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December 2020

Efficacy of BCG vaccine and Mitomycin C for the treatment of ocular squamous cell carcinoma in bovines.

Res Vet Sci 2020 Dec 29;133:48-52. Epub 2020 Aug 29.

Sri Venkateswara Veterinary University|College of Veterinary Science, Tirupati, AP, India.

Bovine ocular squamous cell carcinoma (BOSCC) also called cancer eye, represents the most economically important neoplasm in large animals. Hereditary factors, environmental factors, lack of eyelid pigmentation, age and dietary habits have all been reported to play a role in the etiopathogenesis of bovine ocular squamous cell carcinoma. In group I, six animals with small, localized eye cancer where vision was not affected were included and subjected to intralesional injection of Bacillus Calmette- Guerin (BCG) vaccine at 0, 14, 35, and 56 days interval. Read More

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December 2020

Conjunctival Squamous-Cell Carcinoma.

N Engl J Med 2020 Sep;383(10):e65

Azienda Ospedaliero Universitaria Careggi, Florence, Italy

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September 2020

Demographic features and histopathological diagnosis in primary eyelid tumors: results over 19 years from a tertiary center in Ankara, Turkey.

Int J Ophthalmol 2020 18;13(8):1287-1293. Epub 2020 Aug 18.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara 06620, Turkey.

Aim: To evaluate the demographic features, location, and histopathologic results in primary eyelid tumors.

Methods: We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our service.

Results: Nine hundred and eleven lesions from 874 patients were included in this study. Read More

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Prevalence of Papillomavirus Type-2 Infection and Seropositivity in Asymptomatic Western Canadian Horses.

Vet Pathol 2020 09 19;57(5):632-641. Epub 2020 Aug 19.

7235University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

papillomavirus type 2 (EcPV-2) has been recognized as a potential cause of a subset of genital squamous cell carcinomas (SCCs) in horses. In the current study, we measured EcPV-2 seropositivity in 50 healthy horses from Western Canada, and these were compared to a herd of horses with known EcPV-2 exposure. Second, the presence of EcPV-2 DNA was measured using EcPV-2-specific PCR (polymerase chain reaction), performed on a variety of tissues collected at necropsy from 70 horses that lacked any history, gross, or histologic evidence of neoplasia or papillomavirus-associated disease. Read More

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September 2020

Double primary malignant tumor in a centenarian female: Case report and review of literature.

Nepal J Ophthalmol 2019 Jul;11(22):223-226

Department of Radiation Oncology, All India Institute of Medical Sciences, Raipur, C.G.

A hundred and three year old female patient was evaluated for ulcer over the nasion area and a mass arising from the right upper eyelid, appearing two months apart. Histopathology revealed nasion ulcer as basal cell carcinoma while right eyelid mass was diagnosed as poorly differentiated squamous cell carcinoma. Based on these findings and the time gap between two lesions a diagnosis of synchronous double primary malignant tumor was made. Read More

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Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion.

Am J Case Rep 2020 Aug 13;21:e925134. Epub 2020 Aug 13.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

BACKGROUND Sebaceous gland carcinoma (SGC) is a rare malignant lesion that occurs on the eyelids. It is known to mimic other benign or malignant lesions in clinical presentation, such as a chalazion, basal cell carcinoma, and squamous cell carcinoma. The histopathological diagnosis is the mainstay for diagnosis and is often challenging. Read More

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Frequency of conjunctival epithelial dysplasia in patients with pterygium.

Arq Bras Oftalmol 2020 08 29;83(4):323-328. Epub 2020 Jul 29.

Ophthalmic Pathology Department, Instituto Mexicano de Oftalmología IAP, Querétaro, Mexico.

Purpose: To determine the frequency of ocular squamous surface neoplasia associated with pterygium in an ophthalmology reference center in Central Mexico.

Methods: We reviewed histopathological reports and slides of all patients who underwent pterygium surgery from 2014 to 2016 at the Instituto Mexicano de Oftalmologia in Queretaro (Mexico).

Results: We studied 177 biopsy samples; 66% were from women, and the median age was 52 years. Read More

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Evaluation of the effect of surgical treatment on quality of life with the Dermatology Life Quality Index in patients with facial nonmelanoma skin cancer.

Dermatol Ther 2020 11 14;33(6):e14094. Epub 2020 Aug 14.

Department of Dermatology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.

Skin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Read More

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November 2020