175,807 results match your criteria Squamous Cell Carcinoma Conjunctival


Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas-Reply.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

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December 2018

Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

INSERM UMR-1137, IAME, University of Paris Diderot, Sorbonne Paris Cité, Laboratoire de Virologie, Hôpital Bichat.

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December 2018

New method of sentinel lymph node biopsy in transoral robotic surgery for oropharyngeal squamous cell carcinoma.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e550s. Epub 2018 Dec 10.

Cirurgia de Cabeca e Pescoco, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, BR.

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December 2018
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Squamous cell carcinoma of the tongue in patients older than 45 years.

Braz Oral Res 2018 Dec 6;32:e123. Epub 2018 Dec 6.

Hospital General de México "Eduardo Liceaga", Department of Pathology, México City, México.

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Read More

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December 2018

PATHOLOGIC COMPLETE RESPONSE (YPT0 YPN0) AFTER CHEMOTHERAPY AND RADIOTHERAPY NEOADJUVANT FOLLOWED BY ESOPHAGECTOMY IN THE SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1405. Epub 2018 Dec 6.

Digestive Diseases Surgical Unit and Gastrocenter, Department of Surgery, School of Medical Sciences, State University of Campinas - UNICAMP , Campinas, SP, Brazil.

Background: Esophageal squamous cell carcinoma is an aggressive neoplasia that requires a multidisciplinary treatment in which survival and prognosis are still not satisfactory. The complete pathologic response to neoadjuvant chemotherapy and radiotherapy is considered a good prognosis factor, and esophagectomy is indicated.

Aim: Survival analysis of cases with pathologic complete response (ypT0 ypN0) to neoadjuvant chemotherapy and/or radiotherapy, submmitted to esophagectomy. Read More

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December 2018

Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules.

J Cancer Res Ther 2018 Dec;14(Supplement):S1135-S1140

Department of General Surgery, Peking University International Hospital, Beijing 100026, China.

Background: The exact molecular mechanism of esophageal squamous cell carcinoma (ESCC) is still unknown, and the prognosis of ESCC has not been significantly improved.

Objective: To understand the molecular mechanism of ESCC, differential modules (DMs) and key genes were identified through conducting analysis on the differential co-expression network (DCN) based on the gene expression profiles of ESCC and protein-protein interaction (PPI) data.

Materials And Methods: First, gene expression profiles of ESCC and PPI data recruiting and preprocessing were conducted; then, a DCN was constructed based on the gene co-expression and gene differential expression in ESCC; in the following, candidate DMs were mined from DCN through a systemic module searching strategy, and significance analysis was performed on candidate DMs to identify DMs; moreover, significant genes contained in the DMs were analyzed to identify the underlying biomarkers for ESCC. Read More

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December 2018

Determination of core pathways for oral squamous cell carcinoma via the method of attract.

J Cancer Res Ther 2018 Dec;14(Supplement):S1029-S1034

Department of Dentistry, The Fourth Hospital of Jinan, Jinan, P.R. China.

Objective: We expected to demonstrate a practical framework for oral squamous cell carcinoma (OSCC) candidate biomarker analysis at the pathway level based on the attract method, so as to give great insights to reveal the pathological mechanism underlying this disease at its early stage.

Methods: First, gene expression profile of OSCC was recruited and preprocessed. Then, Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis was conducted. Read More

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December 2018

Eruptive squamous cell carcinomas associated with programmed cell death protein-1 inhibitor therapy.

Indian J Dermatol Venereol Leprol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.

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December 2018

Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.

Objective: To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML).

Subjects And Methods: Whole unstimulated saliva samples were collected from age-, sex-, and race-matched patients who had a lesion in the oral cavity and for whom open biopsies were performed. The patients included OSCC (n = 6), OED (n = 10), and PSOML (n = 32). Read More

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December 2018

A report of human papilloma virus-16 associated vaginal carcinoma after thirty-two years of successful radiation therapy for cervical cancer.

Virusdisease 2018 Dec 3;29(4):537-539. Epub 2018 Aug 3.

1Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104 Karnataka India.

Once the recommended 5-year recurrence-free follow-up is achieved for cervical cancers regular annual pelvic examination is mandatory. The main aim of presenting this short report is to emphasize the difficulties in the collection and interpretation of cytology samples from stenosed cervix or vault after pelvic irradiation. Radiotherapy can induce changes in the cellular morphology which may persist for many years. Read More

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December 2018

Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma.

J Immunol Res 2018 12;2018:1061780. Epub 2018 Nov 12.

"Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.

Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Read More

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November 2018

Yes-Associated Protein 1 as a Novel Prognostic Biomarker for Gastrointestinal Cancer: A Meta-Analysis.

Biomed Res Int 2018 14;2018:4039173. Epub 2018 Nov 14.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Background: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of YAP1 in patients with gastrointestinal cancer. Read More

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November 2018

Mandibular reconstruction with a ready-made type and a custom-made type titanium mesh after mandibular resection in patients with oral cancer.

Maxillofac Plast Reconstr Surg 2018 Dec 25;40(1):35. Epub 2018 Nov 25.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, 20, Geumo-ro, Mulgeum-eup, Yangsan, Gyeongsangnam-do South Korea.

Background: After the resection at the mandibular site involving oral cancer, free vascularized fibular graft, a type of vascularized autograft, is often used for the mandibular reconstruction. Titanium mesh (T-mesh) and particulate cancellous bone and marrow (PCBM), however, a type of non-vascularized autograft, can also be used for the reconstruction. With the T-mesh applied even in the chin and angle areas, an aesthetic contour with adequate strength and stable fixation can be achieved, and the pores of the mesh will allow the rapid revascularization of the bone graft site. Read More

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December 2018

Significant Neutrophilic Emperipolesis in Squamous Cell Carcinoma.

Case Rep Oncol Med 2018 13;2018:1301562. Epub 2018 Nov 13.

Department of Ear, Nose, and Throat Disease, Bakırköy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

A 53-year-old man was admitted for tooth mobility. A mass was identified at the tooth base by CT. Histopathology of the excisional biopsy revealed a moderately differentiated squamous cell carcinoma. Read More

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November 2018

The clinical use of pretreatment NLR, PLR, and LMR in patients with esophageal squamous cell carcinoma: evidence from a meta-analysis.

Cancer Manag Res 2018 22;10:6167-6179. Epub 2018 Nov 22.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541199, China,

Background And Purpose: The relationship between neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) and the prognostic and clinicopathological significance in patients with esophageal squamous cell carcinoma (ESCC) has been reported by many studies. However, inconsistent results have been presented. The current study aimed to investigate the prognostic and clinicopathological role of NLR, PLR, and LMR in patients with ESCC by meta-analysis. Read More

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November 2018

Cytoskeleton-associated protein 4 is a novel serodiagnostic marker for esophageal squamous-cell carcinoma.

Onco Targets Ther 2018 20;11:8221-8226. Epub 2018 Nov 20.

Department of Oncology, Suqian People's Hospital, Nanjing Drum Tower Hospital Group, Suqian, China,

Background: Recent years have witnessed significant progress in the treatment of esophageal squamous-cell carcinoma (ESCC); however, the prognosis of ESCC is still unsatisfactory. Bio-markers are required to improve identification of high-risk populations and help management of ESCC. This study was to evaluate the role of serum CKAP4 in ESCC. Read More

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November 2018

Impact of COPD on prognosis of lung cancer: from a perspective on disease heterogeneity.

Int J Chron Obstruct Pulmon Dis 2018 20;13:3767-3776. Epub 2018 Nov 20.

Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, People's Republic of China,

Background: COPD is an important comorbidity of lung cancer, but the impact of COPD on the outcomes of lung cancer remains uncertain. Because both COPD and lung cancer are heterogeneous diseases, we evaluated the link between COPD phenotypes and the prognosis of different histological subtypes of lung cancer.

Methods: In this retrospective study, subjects with a newly and pathologically confirmed diagnosis of lung cancer were enrolled from patients preparing for lung cancer surgery. Read More

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November 2018

Carcinosarcoma of Tongue with Predominant Osteosarcomatous Component.

Indian J Surg Oncol 2018 Dec 3;9(4):609-612. Epub 2018 Aug 3.

2Department of Head and Neck Oncology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, India.

Carcinosarcoma is exceedingly rare in the oral cavity and shows presence of both carcinomatous and sarcomatous components. We report a case of carcinosarcoma of tongue in a 51-year-old male with predominant osteosarcomatous and squamous cell carcinoma components. There was no evidence of regional or systemic metastatic disease. Read More

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December 2018

Margin Status and Duration of Surgery in Resection of Tongue Carcinoma with Ultrasound Coagulation Device: a Comparative Study.

Indian J Surg Oncol 2018 Dec 20;9(4):501-504. Epub 2018 Jul 20.

Department of Otolaryngology and Head Neck Surgery, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India.

Tongue is one of the most common subsites involved by oral cancer. Improved surgical care and adjuvant therapy, along with better rehabilitation has significantly improved long-term survival and quality of life in patients with oral cancer. Primary surgical treatment is the preferred modality of treatment in cancers of the oral tongue. Read More

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December 2018

Transthoracic Needle Biopsy (TNB) under Different Guiding Methods - the Experience of the Thoracic Surgery Clinic of Craiova after the First 235 Cases.

Curr Health Sci J 2015 Jul-Sep;41(3):239-245. Epub 2015 Mar 15.

Radiology and Imaging Department, University of Medicine and Pharmacy of Craiova, Romania.

Transthoracic needle biopsy (TNB) is a fast and safe method used to establish definitive diagnosis for most thoracic lesions, whether the lesion is located in the pleura, the lung parenchyma, or the mediastinum. Diffuse disease and solitary lesions are equally approachable.TNB can avoid (when technically possible) more complex diagnostic interventions such asmediastinoscopy, thoracoscopy and exploratory thoracotomy. Read More

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Cardiac metastasis of uterine cervical squamous cell carcinoma: A case report and review of the literature.

J Cardiol Cases 2014 Dec 2;10(6):221-225. Epub 2014 Sep 2.

Department of Cardiology, Osaka Medical College, Osaka, Japan.

A 48-year-old woman was referred to the cardiology department due to a large mobile mass in the right ventricle. The patient had undergone radical hysterectomy and bilateral salpingo-oophorectomy for a uterine squamous cell carcinoma approximately 3.5 years before. Read More

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December 2014

A case of atrial tachycardia originating from pulmonary vein invaded by lung cancer.

J Cardiol Cases 2012 Apr 1;5(2):e118-e121. Epub 2012 Feb 1.

Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

A 59-year-old man during chemotherapy for squamous cell carcinoma of the lung, underwent catheter ablation of drug-refractory atrial tachycardia. Pulmonary venography and chest computed tomography revealed presence of stenotic, carcinomatous lesion of the left superior pulmonary vein. Excellent pace map and elimination of inducibility of atrial tachyarrhythmias after left pulmonary isolation suggested that the atrial tachycardia originated from the metastatic region. Read More

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Acute myocardial infarction due to malignant neoplastic coronary embolus.

J Cardiol Cases 2010 Dec 11;2(3):e123-e127. Epub 2010 Jun 11.

Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

A 54-year old man was diagnosed with right lung carcinoma (squamous cell carcinoma, SCC), stage IIIB (c-T2N3M0). Transthoracic echocardiography (TTE) showed a huge 8.9 cm × 1. Read More

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December 2010

Three-gene immunohistochemical panel predicts progression and unfavorable prognosis in esophageal squamous cell carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi 832002, China. Electronic address:

Esophageal squamous cell carcinoma (ESCC) is a highly invasive disease with a poor long-term survival rate. Although there has been progress in understanding the pathogenesis of ESCC, there are currently no molecular biomarkers that are used in routine clinical practices to determine prognosis. Therefore, the aim of this study was to determine a small immunohistochemical (IHC) panel that could predict the prognosis of patients with ESCC. Read More

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December 2018
2.769 Impact Factor

The value of immunotherapy in head and neck cancer.

Expert Opin Biol Ther 2018 Dec 11. Epub 2018 Dec 11.

d Marlene and Stewart Greenebaum Comprehensive Cancer Center , University of Maryland School of Medicine , Baltimore , Maryland.

Introduction: Head and neck squamous cell carcinomas (HNSCC) previously had limited treatment options once patients had progressed on systemic chemotherapy. With recent advances, immunotherapy now plays an important role in the treatment of advanced disease with improved outcomes as compared to cytotoxic chemotherapy. Areas covered: This article reviews the effects of the immune system and how it influences the development and response to HNSCC therapy. Read More

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December 2018
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Prognostic performance of the American Joint Committee on Cancer 8th edition of the TNM staging system in patients with early oral tongue cancer.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Departments of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Background: The 8th edition of the American Joint Committee on Cancer's (AJCC) staging system for oral cavity cancer incorporates pathological features. We aimed to assess whether these changes results in better risk stratification of patients with early oral tongue squamous cell carcinoma (OTSCC).

Methods: Overall survival (OS) and disease-specific survival (DSS) of 244 patients were calculated using the Kaplan-Meier method. Read More

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December 2018

Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival.

Methods: A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. Read More

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December 2018

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain.

Background: Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC).

Objective: To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. Read More

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December 2018
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Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.

Background: Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient.

Methods: Homemade AgNP solution is manufactured using online instructions by a 78-year old male. Read More

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December 2018

Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

School of Dentistry, National Defense Medical Center, Taipei, Taiwan.

Background: Aberrant expression of decoy receptor 3 (DcR3) is considered to be a diagnostic and therapeutic target for human cancers. The aim of this study was to assess DcR3 as a target of the anticancer effects of triptolide (TPL) in preclinical patient-derived tumor xenograft (PDTX) models of oral squamous cell carcinoma (OSCC).

Methods: The expression of DcR3 was evaluated through immunohistochemistry, and correlations were examined using clinical variables. Read More

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December 2018
1 Read

Long noncoding RNA CASC9 promotes LIN7A expression via miR-758-3p to facilitate the malignancy of ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck and Genito-Urinary Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

The long noncoding RNA cancer susceptibility 9 (CASC9) has been reported to be a pivot modulator in growth and metastasis of breast cancer, liver cancer, esophageal squamous cell carcinoma, lung adenocarcinoma, gastric cancer, and nasopharyngeal cancer. However, its potential roles in ovarian cancer remain unclear. In this study, we aimed at its functions and molecular mechanism in ovarian cancer progression. Read More

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December 2018

Post-diagnosis aspirin use and survival in veterans with head and neck cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia.

Background: Our objective was to determine the effect of post-diagnosis aspirin use on survival in veterans with head and neck squamous cell carcinoma.

Methods: Retrospective cohort study of 584 veterans with head and neck squamous cell carcinoma treated at the Washington DC VA Medical Center between 1995 and 2015. Charts were queried for clinical-pathologic data, aspirin prescriptions, and outcome. Read More

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December 2018
2 Reads

Cutaneous malignant melanoma of the oral cavity following skin graft reconstruction: Case report.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.

Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.

Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More

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December 2018
2 Reads

miR-133a-3p suppresses cell proliferation, migration, and invasion and promotes apoptosis in esophageal squamous cell carcinoma.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Oncology, Linyi People's Hospital, Linyi, Shandong, China.

Objective: This study aimed to investigate the expression levels of miR-133a-3p and collagen type I α 1 (COL1A1) in esophageal squamous cell carcinoma (ESCC) to find out the relationship between miR-133a-3p and COL1A1 and their influence on ESCC propagation, migration, invasion, and apoptosis.

Methods: The messenger RNA expression levels of miR-133a-3p and COL1A1 in ESCC were detected by quantitative reverse-transcription polymerase chain reaction. The expression of COL1A1 protein was examined via western blot analysis and immunohistochemistry assay. Read More

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December 2018

Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

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December 2018
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Long noncoding RNA HOXC13-AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR-383-3p/HMGA2 axis.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University No. 1, Zhengzhou, Henan, China.

Long noncoding RNAs have been reported to be important regulators in numerous cancers. In this study, we found that HOXC13 antisense RNA (HOXC13-AS) was highly expressed in head and neck squamous carcinoma (HNSC) tissues in The Cancer Genome Atlas database. Nasopharyngeal carcinoma (NPC) belongs to HNSC. Read More

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December 2018
2 Reads

Is the positive predictive value of high-grade cytology in predicting high-grade cervical disease falling due to HPV vaccination?

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

VCS Population Health, VCS Foundation, Level 6, 176 Wellington Parade, East Melbourne, VIC, 3002, Australia.

A fall in the positive predictive value (PPV) of cytological predictions of high-grade squamous intraepithelial lesions (HSIL) or adenocarcinoma-in-situ (AIS) has been predicted in the post HPV vaccination era due to the decrease in underlying prevalence of cervical lesions. Data was extracted from the Victorian Cervical Screening Registry including cervical cytology tests taken between 2000 and 2016 and any subsequent histology performed within six months of the cytology. PPV was calculated for each age group (<20, 20-24, 25-29, 30-34, 35-39, 40-49, 50-59, 60-69, 70+ years) and calendar year. Read More

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December 2018

Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A.

Objectives/hypothesis: The authors used the Surveillance, Epidemiology, and End Results (SEER) database to analyze epidemiological features of patients presenting with supraglottic squamous cell carcinoma (SCCa) and to evaluate treatment trends and outcomes.

Methods: The SEER database was queried for patients with supraglottic SCCa from 1973 to 2013. Information on demographics; tumor size; histologic grade; American Joint Committee on Cancer (AJCC) stage; SEER local, regional, distant stage; and treatment modality were analyzed. Read More

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December 2018
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Detection of extracellular vesicles in the mouse vaginal fluid: Their delivery of sperm proteins that stimulate capacitation and modulate fertility.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Biological Sciences, University of Delaware, Newark, Delaware.

Extracellular vesicles (EVs) were isolated by ultracentrifugation of vaginal luminal fluid (VLF) from superovulated mice and identified for the first time using transmission electron microscopy. Characterized by size and biochemical markers (CD9 and HSC70), EVs were shown to be both microvesicular and exosomal and were dubbed as "Vaginosomes" (VGS). Vaginal cross-sections were analyzed to visualize EVs in situ: EVs were present in the lumen and also embedded between squamous epithelial and keratinized cells, consistent with their endogenous origin. Read More

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December 2018

Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy.

Background: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. "Compartmental" hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by "en bloc" removal of tumor and its pathways of spread.

Methods: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Read More

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December 2018
2 Reads

A clinical trial with protracted infusion 5-fluorouracil and mitomycin C for localized squamous cell carcinoma of the anus.

Asia Pac J Clin Oncol 2018 Dec 9. Epub 2018 Dec 9.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Purpose: Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcomes of patient-initiated treatment interruption for severe acute toxicity.

Materials And Methods: This was a prospective, nonrandomized study for patients with T1-4N0-3M0 anal squamous carcinoma. Read More

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December 2018
2 Reads

Astragaloside IV inhibits cell proliferation in vulvar squamous cell carcinoma through the TGF-β/Smad signaling pathway.

Dermatol Ther 2018 Dec 7:e12802. Epub 2018 Dec 7.

From the Department of Gynecology, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, P.R. China.

Objective: To explore the inhibition of the proliferation of vulvar squamous cell carcinoma (VSCC) by astragaloside IV.

Methods: MTT examined the cell proliferation of VSCC. Flow cytometry analyzed cell cycle and apoptosis. Read More

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December 2018

Outcomes of relapsed human papillomavirus-related oropharyngeal squamous cell carcinoma treated with curative intent.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Washington University, Saint Louis, Missouri.

Background: With most centers reporting excellent disease control following transoral surgery for human papillomavirus (HPV)-related oropharyngeal cancer, data are still lacking regarding management and outcomes in patients who relapse. We describe the treatment outcomes after curative intent therapy for locoregional and distant relapse following transoral surgery for HPV-related oropharyngeal squamous cell carcinoma (OPSCC).

Methods: A single institution retrospective study in which patients were identified with curatively treated loco-regional or single site distant relapse of HPV-related OPSCC treated initially with transoral surgery (TOS) between 1996 and 2014. Read More

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December 2018

Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.

Background: The purpose of this study was to comprehensively characterize head and neck squamous cell carcinoma (HNSCC) arising in young patients (<45 years old).

Methods: We performed immunohistochemistry, silver, and fluorescence in situ hybridization using samples obtained from 396 radically resected cases among 1787 HNSCCs.

Results: Young age HNSCCs occurred in 10. Read More

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December 2018

Elective neck dissection in metastatic cutaneous squamous cell carcinoma to the parotid gland: A systematic review and meta-analysis.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Otolaryngology, Head & Neck Surgery, Monash Health, Melbourne, Australia.

Current management of metastatic cutaneous squamous cell carcinoma (CSCC) to the parotid is surgical excision and postoperative radiotherapy. In the node-negative neck, there is debate about the role of elective neck dissection (END), irradiation or observation. This systematic review assesses the prevalence of occult cervical disease and the evidence for END. Read More

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December 2018

Sclerosis of the arytenoid cartilage and glottic carcinoma: A clinical-pathological study.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Otolaryngology Unit, Vittorio Veneto Hospital, Treviso, Italy.

Background: Given the relevance of any tumor invasion of the arytenoid cartilage or crico-arytenoid unit to the planning open partial horizontal laryngectomy (OPHL) for laryngeal squamous cell carcinoma (LSCC), it is important to have a reliable radiological test to assess impairments of these structures.

Methods: We retrospectively compared the endoscopic, radiological, and pathological findings in patients with glottic LSCC who underwent OPHL.

Results: The endoscopic finding of a reduced (impaired or absent) vocal cord motility proved more sensitive, with better positive and negative predictive values, but less specific than the radiological finding of complete arytenoid sclerosis in detecting histologically assessable infiltration of the arytenoid cartilage. Read More

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December 2018
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Recurrence of periocular basal and squamous cell carcinoma after Mohs Micrographic Surgery: a retrospective cohort study.

Br J Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Despite the widespread use of Mohs Micrographic Surgery (MMS) for periocular basal and squamous cell carcinoma (together called keratinocyte carcinoma (KC)), follow-up data regarding recurrences are limited.

Objectives: To investigate the recurrence rate for periocular KCs after MMS and describe experience with interdisciplinary collaborations.

Methods: Patients with periocular KCs treated with MMS between 2006 and 2016 in a tertiary MMS referral hospital were included in this retrospective cohort study. Read More

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December 2018

Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta-analysis.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine, Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland.

Background: The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous-like lesions with high risk of malignancy, and its biomarkers.

Methods: A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta-analysis was possible for human papillomavirus (HPV), aneuploidy, Ki-67, and p53. Read More

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December 2018
5 Reads