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Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Diagnostic Pathology, Shizuoka Cancer Center Hospital, Sunto, Japan.

Abstract: This study sought to reveal the clinicopathologic characteristics of large cell neuroendocrine carcinoma (LCNEC) of the skin/conjunctiva. The retrieved patients included 3 men and 3 women with a median age of 85 (63-95) years. All lesions occurred on the face, including the ears, with a median tumor size of 11. Read More

Orbit 2022 May 26:1-4. Epub 2022 May 26.

Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology Massachusetts Eye and Ear, Harvard Medical SchoolDavid G. , Boston, Massachusetts, USA.

A 71-year-old female with invasive squamous cell carcinoma of the lower eyelid involving the ocular surface underwent surgical excision with negative margins and a subsequent reconstruction. The posterior lamellar defect was reconstructed with a Hughes tarsoconjunctival flap, and the anterior lamellar defect was reconstructed by advancing the lower eyelid skin. Three years later, the patient presented with signs suspicious for recurrence involving the tarsoconjunctival graft: a nodule along the mucocutaneus junction, symblepharon, and forniceal shortening. Read More

Am J Ophthalmol Case Rep 2022 Jun 11;26:101580. Epub 2022 May 11.

Ophthalmology and Visual Sciences Department, Universidade Federal de São Paulo (Unifesp - EPM), R. Botucatu, 822 - Vila Clementino, São Paulo, SP, 04023-062, Brazil.

Purpose: Leiomyosarcoma (LMS) is a mesenchymal neoplasm with smooth muscle differentiation, being considered one of the most common soft tissue sarcomas. However, it rarely affects the eye, and when it does, it is usually located in the orbit, being extremely rare in the conjunctiva.

Observations: We report a case of a 45 years old male patient, with a recurrent rapid growing conjunctival mass on the temporal limbus of his left eye, which was excised, and the anatomopathological report was suggestive of a grade 1 leiomyosarcoma. Read More

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Rotterdam Eye Hospital, Schiedamse Vest 180, 3011 BH Rotterdam, The Netherlands.

An Ocular Sebaceous Carcinoma (OSC) is a rare malignant tumor for which initial clinical and pathological diagnosis is often incorrect. OSCs can mimic Squamous Cell Carcinomas of the Conjunctiva (SCCC). The aim of this study was to find microRNA biomarkers to distinguish OSCs and SCCCs from normal tissue and from each other. Read More

Int Ophthalmol 2022 May 7. Epub 2022 May 7.

Operation Eyesight, Universal Institute for Eye Cancer (VSV, SK), L V Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To describe the risk factors, clinical features, management, and outcomes in patients with metastatic conjunctival squamous cell carcinoma (mcSCC).

Methods: Retrospective comparative study.

Results: Of the 1192 cases with ocular surface squamous neoplasia during the study period, 654 (55%) patients were biopsied and 223 (19%) had invasive squamous cell carcinoma (cSCC). Read More

Front Oncol 2022 14;12:864066. Epub 2022 Apr 14.

Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States.

Background: The etiopathogenesis of ocular surface squamous neoplasia (OSSN) is not fully understood. We assessed the frequency of oncogenic viruses in OSSN by immunohistochemistry (IHC) and polymerase chain reaction (PCR) for human papillomavirus (HPV), Epstein-Barr virus (EBV), Merkel cell polyomavirus (MCPyV), Kaposi sarcoma virus, and adenovirus. Cases from Zambia were prospectively enrolled using a cross-sectional study design between November 2017 and March 2020. Read More

Can J Ophthalmol 2022 Apr 28. Epub 2022 Apr 28.

Faculty of Medicine, McGill University, Montreal, Que.. Electronic address:

Salud Publica Mex 2022 Apr 8;64(2):209-217. Epub 2022 Apr 8.

Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra. Mexico City, Mexico.

Objective: To investigate the association of high-risk hu-man papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN).

Materials And Methods: We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consump-tion information. Read More

Arq Bras Oftalmol 2022 Mar 7. Epub 2022 Mar 7.

Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the impact of social isolation due to the COVID-19 pandemic on the number of new cases and therapeutic approaches at the Ocular Oncology division from the Universidade Federal de São Paulo (UNIFESP).

Methods: A retrospective study was conducted by medical records review of new patients treated before the pandemic from March 2019 to September 2019 (pre-pandemic group) and during the pandemic from March 2020 to September 2020 (pandemic group). Data regarding age, sex, ethnicity, place of origin, clinical diagnosis, time since referral, and proposed therapy were analyzed. Read More

BMJ Open Ophthalmol 2022 23;7(1):e000977. Epub 2022 Mar 23.

Department of Public Health, University of Livingstonia, Mzuzu, Malawi.

Objective: Orbito-ocular cancers are a common cause of morbidity and mortality in our population, yet these cancers have not been adequately described in Malawi. This study sought to describe the burden and histopathological profile of orbito-ocular cancers in Northern Malawi.

Methods And Analysis: A retrospective review of pathology reports was done. Read More

PLoS One 2022 31;17(3):e0263895. Epub 2022 Mar 31.

Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.

Conjunctival squamous cell carcinoma (SCC) is the most common ocular surface neoplasia. The purpose of this retrospective study was to examine the role of regulatory T cell (Treg) activity in tumor immunity and investigate the tumor microenvironment as a new treatment focus in conjunctival SCC. Cancer progression gene array and immunohistochemical analyses of FOXP3 as a Treg marker, CD8 as a tumor-infiltrating lymphocyte marker, and CXCR4 expression on activated Tregs were conducted in a series of 31 conjunctival SCC cases. Read More

Case Rep Ophthalmol 2022 Jan-Apr;13(1):89-95. Epub 2022 Feb 14.

Olmsted Medical Center, Department of Ophthalmology, Rochester, Minnesota, USA.

Topical erythropoietin has been recently introduced for the treatment of avascular conjunctival and scleral lesions. Before this treatment can be routinely used, however, its safety profile and contraindications should be determined. Herein, we report a case of recurrent conjunctival squamous cell carcinoma (SCC) and intraocular tumor extension after treatment with topical erythropoietin for excisional biopsy-induced scleral necrosis. Read More

Arq Bras Oftalmol 2022 Mar 21. Epub 2022 Mar 21.

Department of Ophthalmology, Fundação Altino Ventura, Recife, PE, Brazil.

Purpose: To evaluate the impact of corneal and conjunctival tumors on the ocular surface and quality of life of patients before and after surgical treatment.

Methods: This prospective study conducted a preoperative and 30- and 90-day postoperative assessment of patients diagnosed with conjunctival and corneal tumors. Demographic data were collected preoperatively. Read More

J Interferon Cytokine Res 2022 03;42(3):137-139

Department of Vitreo-Retina and Uveitis, Eye Life, Mumbai, Maharashtra, India.

We describe a rare case of a 58-year-old female with ocular surface squamous neoplasia (OSSN) in her left eye. She was treated for 12 months with topical interferon alpha-2b (IFNα-2b) eye drops and OSSN resolved completely. She presented with a whitish elevated lesion involving the cornea, limbus, and conjunctival surface after discontinuation of topical IFNα-2b. Read More

BMC Ophthalmol 2022 Mar 12;22(1):121. Epub 2022 Mar 12.

Department of Pathology, Faculty of Medicine, Chiang Mai University, 110 Intavaroros Road, Chiang Mai, 50200, Thailand.

Purpose: To evaluate clinical characteristics, treatments, and outcomes in patients with ocular surface squamous neoplasia (OSSN) at a tertiary center in Northern Thailand.

Methods: Patients diagnosed with either corneal-conjunctival intraepithelial neoplasia (CIN) or squamous cell carcinoma (SCC) from May 2000 to December 2015, were recruited. The patients' demographics, symptoms, clinical characteristics, cytopathology, treatments, and outcomes were reviewed. Read More

Indian J Ophthalmol 2022 Mar;70(3):971-975

Oculo Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Mutations in human telomerase reverse transcriptase (TERT) are associated with increased telomerase activity in cutaneous melanomas. Conjunctival squamous cell carcinoma, also referred to as ocular surface squamous cell carcinoma, is cancer on the surface of the eye. Recent studies have identified UV signat`ure mutations in TERT promoters in ocular melanoma and ocular surface squamous neoplasia. Read More

J Skin Cancer 2022 18;2022:4075668. Epub 2022 Feb 18.

Department of Pathology, Northern International Medical College, Dhaka, Bangladesh.

Background: Eyelid tumours are common in our ophthalmic practice. Malignancy cases account only for one-fourth of all eyelid tumours. The most aggressive eyelid malignancy is sebaceous gland carcinoma, but its occurrences are rare in western countries. Read More

Eye (Lond) 2022 Feb 3. Epub 2022 Feb 3.

Ophthalmic Biophysics (AM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the risk factors, clinical features, histopathology, treatment, and outcomes of patients with orbital tumour extension of ocular surface squamous neoplasia (OSSN).

Methods: Retrospective study of 51 patients with orbital tumour extension (cases) and 360 patients without orbital extension (controls).

Results: Of 1,653 patients with OSSN, orbital tumour extension was noted in 51 (3%) cases. Read More

Int Ophthalmol 2022 Jun 30;42(6):1915-1926. Epub 2022 Jan 30.

Ophthalmic Pathology Services, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the clinical features, histopathology, treatment, and outcomes of patients with ocular surface squamous neoplasia (OSSN) presenting to a referral centre in India.

Methods: Retrospective interventional study.

Results: Of 438 patients, the mean age at presentation was 49 years. Read More

Int J Surg Case Rep 2022 Feb 24;91:106785. Epub 2022 Jan 24.

San Jose Hospital, Professor at Fundación Universitaria de Ciencias de la Salud (University Foundation of Health Sciences), Colombia.

Introduction: The prevalence of squamous cell carcinoma of the eyeball is low, and this is a rare condition. There are multiple therapeutic strategies for the treatment and depend on the degree of local involvement and extension of the tumor which, in turn, will have an impact on the patient's prognosis.

Presentation Of Case: We present a case of a patient with a mass of progressive growth on the left eyeball whit vision damage. Read More

Medicine (Baltimore) 2022 Jan;101(4):e28698

Department of Ophthalmology, Fudan Eye & ENT Hospital, Shanghai, China.

Abstract: The conventional procedure of anterior orbital exenteration is unfavorable for eye socket reconstruction, whereas a modified procedure enables socket reconstruction and prosthesis fitting. Our study aims to compare the cosmetic outcomes between these 2 surgical techniques.We retrospectively recruited patients treated with modified or conventional exenteration during January 2015 to May 2021 in our hospital. Read More

Indian J Pathol Microbiol 2022 Jan-Mar;65(1):3-7

The Operation Eyesight Universal Institute for Eye Cancer, Hyderabad, Telangana, India.

Background: Ocular surface squamous neoplasia (OSSN) comprises neoplasm arising from the ocular surface, which includes conjunctiva, cornea, and limbus and ranges from mild dysplasia to invasive squamous cell carcinoma.

Purpose: The aim of this work was to study the spectrum of OSSN based on histopathological analysis. Materials and. Read More

Ophthalmology 2022 02;129(2):146

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.

Am J Surg Pathol 2022 Jul 5;46(7):977-987. Epub 2022 Jan 5.

Departments of Anatomic Pathology.

High-risk human papillomavirus (HPV) infection in conjunctival and lacrimal sac squamous cell carcinomas (SCCs) has been sporadically reported; however, its prevalence, clinicopathologic significance and surrogate markers have not been fully elucidated. Here, we attempted to clarify these questions in Japanese patients with conjunctiva and lacrimal sac SCCs. We retrospectively collected 51 conjunctival SCC and 7 lacrimal sac SCC samples and analyzed them for (1) transcriptionally active high-risk HPV infection using messenger RNA in situ hybridization and (2) protein expressions of p16 and Rb using immunohistochemistry (IHC). Read More

Ophthalmologe 2022 Mar 3;119(3):234-239. Epub 2021 Dec 3.

Poliklinik und Klinik, Universitätsmedizin Mainz, Langenbeckstr 1, 55131, Mainz, Deutschland.

Background: By identifying diseases of the anterior segment of the eye associated with exposure to UV light, recommendations for action can be derived.

Aim: After reading this review, the reader should be familiar with UV light-associated diseases of the anterior segment of the eye.

Method: Using a selective literature search, UV light-associated diseases of the anterior segment of the eye were identified and protective mechanisms are described. Read More

J Epidemiol Glob Health 2022 03 30;12(1):25-39. Epub 2021 Nov 30.

King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Background: Conjunctival lesions are common with a wide spectrum of benign, premalignant, and malignant lesions. Few histopathological studies have been conducted on conjunctival lesions with variable designs and results. Our aim in this study is to provide information on common conjunctival lesions seen in an ophthalmology tertiary care center in Saudi Arabia. Read More

Br J Ophthalmol 2021 Nov 29. Epub 2021 Nov 29.

Ocular Oncology Service, Centre for Sight, Hyderabad, Telangana, India.

Background/aim: To evaluate the safety and efficacy of ruthenium-106 (Ru-106) plaque brachytherapy in managing invasive ocular surface squamous neoplasia (OSSN).

Methods: This is a retrospective, non-comparative, interventional case series of 42 eyes with OSSN with histopathologically-proven corneal stromal and/or scleral invasion that underwent Ru-106 plaque brachytherapy. Main outcome measures were tumour regression, eye salvage, final visual acuity, treatment complications and metastasis. Read More

Int J Biol Macromol 2022 Jan 24;195:93-101. Epub 2021 Nov 24.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th St, Miami, FL 33136, USA.

Mutations in the titin (TTN) gene are among the most common genomic aberrations in ocular surface squamous neoplasia (OSSN), the most common cancer of the external eye. Further, TTN mutations are associated with resistance to standard therapy with topical interferon alpha-2b (IFN-α2b). However, it remains unclear how TTN mutations drive OSSN pathogenesis and treatment resistance. Read More

Indian J Ophthalmol 2021 Dec;69(12):3776-3777

Department of Cornea Services, Shri Ganapati Netralaya, Jalna, Maharashtra, India.