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Clin Ter 2019 Mar-Apr;170(2):e81-e83

Ophthalmology Department. Hospital General. Granollers, España.

Purpose: We report a rare case of rapid transformation of a conjunctival keratoacanthoma (KA) into a highly aggressive squamous cell carcinoma requiring enucleation. To our knowledge, this is the second such case reported in the literature.

Methods: Case report. Read More

J Interferon Cytokine Res 2019 Apr 5. Epub 2019 Apr 5.

1 Department and Clinic of Ophthalmology, University of Wrocław Medical College, Wrocław, Poland.

Interferon alpha (IFN-α) is a glycoprotein with antitumor, antiviral, and immunomodulatory activity, used widely in the treatment of viral infections (hepatitis B and C, condylomata acuminata, herpes zoster, etc.), hematological disorders (leukemia, multiple myeloma, T cell lymphoma, and essential thrombocythemia), and solid tumors (clear cell carcinoma in the metastatic stage, melanoma, hepatocellular carcinoma, and cervical neoplasia). Studies have proven the effectiveness of IFN-α in the treatment of ophthalmic disorders involving the anterior segment of the eye (conjunctival papilloma, squamous neoplasia, conjunctival mucosa-associated lymphoid tissue, Mooren's ulcer, and vernal keratoconjunctivitis) and the posterior segment of the eye (serpiginous choroidopathy, posterior uveitis, pseudophakic and diabetic cystoid macular edema, and proliferative diabetic retinopathy). Read More

J Fr Ophtalmol 2019 Apr 21;42(4):387-390. Epub 2019 Mar 21.

Service d'ophtalmologie, hôpital militaire régional Oran, Oran, Algérie.

Squamous cell carcinoma is the most common malignant tumor of the bulbar conjunctiva. However, it often remains under-diagnosed and exposed to therapeutic delay. The aim of this work is to elucidate the diagnostic and therapeutic difficulties posed by this tumor and to appreciate its prognosis. Read More

Equine Vet J 2019 Mar 23. Epub 2019 Mar 23.

Veterinary Medical Teaching Hospital, University of California-Davis, Davis, California, USA.

Background: Belgian horses are commonly affected with ocular squamous cell carcinoma (SCC), the most common cancer of the equine eye. A missense mutation in damage-specific DNA binding protein 2 (DDB2 c.1013C>T, p. Read More

Health Sci Rep 2019 Feb 10;2(2):e108. Epub 2019 Jan 10.

Department of Internal Medicine, Rogel Cancer Center Michigan Medicine Ann Arbor Michigan USA.

Background And Aims: Conjunctival squamous cell carcinoma (CSCC) varies in incidence geographically from 0 to 1 case per 100 000 per year globally. Additionally, the incidence of CSCC is known to increase 49% for every 10° decrease in latitude. Since the onset of the AIDS epidemic, there has been a trend of increasing incidence of CSCC in Africa, and despite relatively stable levels of ultraviolet (UV) exposure, there is an observed 12 times greater risk of developing CSCC when individuals are infected with HIV. Read More

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):150-155

Department of Ophthalmology, Mbarara University of Science and Technology and Ruharo Eye Centre, Mbarara, Uganda.

Aim: The aim of the study was to assess the predictors of ocular surface squamous neoplasia (OSSN) and conjunctival squamous cell carcinoma (SCC) among Ugandan patients.

Materials And Methods: Patients presenting for removal of ocular surface lesions received human immunodeficiency virus (HIV) testing, completed questionnaires about demographic, behavioral, and historical potential risk factors for conjunctival neoplasia, and had lesions examined for interpalpebral versus other locations, rough versus smooth texture, and number of feeder vessels. Biopsies were classified pathologically using standard definitions classified OSSN and SCC. Read More

Ophthalmic Plast Reconstr Surg 2019 Jan 25. Epub 2019 Jan 25.

Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York.

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Aims: To systematically describe the clinical and histopathological features of a case series of conjunctival carcinomatous lesions underlying as-and also masquerading-pyogenic granuloma.

Methods: Nine cases of conjunctival carcinomatous lesions underlying a pyogenic granuloma (which were clinically predominant) were retrospectively identified. Patients' records were analysed for demographic data, clinical appearance and the postoperative course. Read More

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

Ocul Oncol Pathol 2019 Jan 29;5(1):60-65. Epub 2018 Jun 29.

Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Squamous cell carcinoma (SCC) of the orbit is almost uniformly the result of local invasion from a cutaneous primary, extension by perineural invasion, or the result of metastasis. This is owed to the lack of native squamous epithelium in the orbit. After review of the literature, to date, only 6 reports of 8 patients with primary orbital SCC exist. Read More

Cesk Slov Oftalmol Winter 2018;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

Ocul Oncol Pathol 2018 Jun 19;4(4):240-249. Epub 2018 Jan 19.

Department of Pathology and Laboratory Medicine, Atlanta, GA, USA.

Aim: To describe 4 cases of conjunctival squamous cell carcinoma (SCC) with corneal stromal invasion.

Methods: Retrospective, clinicopathologic case series.

Results: All patients had prior resections of presumed pterygia. Read More

Am J Ophthalmol 2019 Apr 8;200:226-241. Epub 2019 Jan 8.

Division of Head and Neck Pathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Purpose: Novel cancer immunotherapies, called immune checkpoint inhibitors, have demonstrated clinical efficacy in the treatment of squamous cell carcinomas of the head and neck. Tissue expression of programmed cell death 1 ligand 1 (PD-L1) and programmed cell death 1 ligand 2 (PD-L2) has been shown to predict tumor response to these drugs. We examine the expression of prognostic immune biomarkers, PD-L1 and PD-L2, in invasive ocular surface squamous neoplasia. Read More

World J Clin Cases 2018 Dec;6(16):1194-1198

Departments of Radiation Oncology, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, South Korea.

Background: Primary sebaceous carcinoma of lacrimal gland (SCLG) is extremely rare. Due to its clinical characteristics, it is often misdiagnosed. It is known to be aggressive so delay in diagnosis can increase the chance of local recurrence and metastasis. Read More

Eye (Lond) 2019 02 28;33(2):283-294. Epub 2018 Dec 28.

School of Clinical Sciences, University of Edinburgh, Edinburgh, UK.

Purpose: To describe the incidence, associations and outcomes of ocular surface squamous neoplasia (OSSN) in the United Kingdom.

Methods: Prospective, observational study of every new case of OSSN reported via the British Ophthalmological Surveillance Unit reporting scheme over a 12-month period. Cases were followed up for 12 months. Read More

Respir Med Case Rep 2019 8;26:101-104. Epub 2018 Dec 8.

Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, 430-0906 2-12-12, Sumiyoshi Naka-ku, Hamamatsu-city, Shizuoka, Japan.

A 61-year-old woman with a history of palpebral conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma, treated with rituximab, was referred to the authors' hospital after follow-up positron emission tomography/computed tomography revealed F-fluoro-2-deoxy-d-glucose uptake in a tumor located in the left main bronchus. The diagnosis of MALT lymphoma was made by pathological and immunohistochemical findings homologous to previous palpebral conjunctival lesion via bronchoscopic biopsy. The disease was controlled with rituximab, cyclophosphamide, oncovin, and prednisolone (i. Read More

Am J Ophthalmol 2019 Apr 12;200:1-9. Epub 2018 Dec 12.

Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.

Purpose: Ocular surface squamous neoplasia includes a spectrum of diseases from dysplasia to invasive squamous cell carcinoma (SCC) of the conjunctiva. Whether the degree of invasion influences outcomes is debated. We evaluated the outcomes and management of conjunctival carcinomas defined as ≤0. Read More

Ann Chir Plast Esthet 2019 Feb 30;64(1):44-53. Epub 2018 Nov 30.

Département de chirurgie plastique, reconstructrice, brûlés, plaies et cicatrisation, CHU Lapeyronie, 371, avenue de Doyen Gaston Giraud, 34295 Montpellier, France. Electronic address:

Objectives: Blepharopoiesis represents a double aesthetic and functional challenge. If anterior lamellar reconstruction is less discussed, the variety of posterior lamellar substitutes testifies that none is ideal. We report here our experience of the use of autologous dermal dermis as posterior lamellar substitutes in bilamellar blepharopoiesis. Read More

Transplantation 2019 Mar;103(3):e59-e60

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Pan Afr Med J 2018 19;30:139. Epub 2018 Jun 19.

Faculté de Médecine et de Pharmacie de Fès, CHU Hassan II, Fès, Maroc.

We here report the case of a 48-year old patient with a family history of five deaths due to cancers with different localizations, presenting with ulcero-budding nodular swelling of the lower palpebral conjunctiva measuring 2cm long its longer axis, gradually increasing volume over one year. It involved the inner half of the lower tarsal conjunctiva closely with the lower lacrimal punctum (A). Tumor biopsy showed well differentiated squamous carcinoma of the conjunctiva. Read More

Med Dosim 2018 Oct 23. Epub 2018 Oct 23.

Department of Radiation Oncology, University of Oklahoma Health Sciences Center, and Stephenson Cancer Center, Oklahoma City, OK 73104, USA. Electronic address:

The primary occurrence of mucoepidermoid carcinoma (MEC) of the conjunctiva is extremely rare, aggressive, and easily mistaken for squamous cell carcinoma. With fewer than 50 cases reported in the literature, there is no consensus on the most effective treatment. Radiation is an alternative to enucleation or orbital exenteration with the potential of eye preservation. Read More

Indian J Ophthalmol 2018 Nov;66(11):1569-1573

Oculoplasty, Orbit and Ocular Oncology Services, Centre for Sight, Hyderabad, Telangana, India.

Purpose: To determine the role of primary limbal stem cell transplantation (LSCT) in managing extensive ocular surface squamous neoplasia (OSSN) with more than 3 quadrants of limbal involvement to prevent manifestations of limbal stem cell deficiency.

Methods: A multi-center, comparative, and interventional clinical study of cases and historical controls was done. Patients with a limbal mass suggestive of OSSN involving more than 3 quadrants of limbus (> 9 clock hours) and no local, regional or systemic metastasis, who underwent primary surgical excision with or without adjuvant chemotherapy and had a minimum follow-up of 12 months were included in this study. Read More

Eye (Lond) 2019 02;33(2):332-333

Oculoplasty and Ocular Oncology Services, Dr R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.

Eye (Lond) 2019 02 18;33(2):331-332. Epub 2018 Oct 18.

Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.

Ocul Oncol Pathol 2018 Sep 13;4(5):298-303. Epub 2018 Feb 13.

Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone.

Cases: Two patients with 360 degrees of limbal involvement.

Results: Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Read More

Clin Ophthalmol 2018 1;12:1901-1904. Epub 2018 Oct 1.

Department of Ophthalmology, The Ohio State University Havener Eye Institute, Columbus, OH, USA,

Objective: To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia.

Materials And Methods: This is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric -test. Read More

Am J Ophthalmol 2019 Feb 9;198:45-53. Epub 2018 Oct 9.

The New York Eye Cancer Center, New York, New York, USA.

Purpose: The purpose of this study was to evaluate super-thick amniotic membrane grafts (ST-AMGs) for ocular surface reconstruction.

Design: Retrospective, interventional case series.

Methods: This was a single-center study of clinical practice that included select patients with typically large ocular surface abnormalities that required reconstruction. Read More

J Formos Med Assoc 2019 Apr 25;118(4):776-782. Epub 2018 Sep 25.

Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan; Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan; Department of Ophthalmology, College of Medicine, Fu Jen Catholic University, Taiwan. Electronic address:

Background/purpose: To describe the clinical and histologic characteristics of ocular surface squamous neoplasia (OSSN) and evaluate factors significant in recurrence at a university hospital in North Taiwan.

Methods: Patient charts, clinical features, and pathology records were retrospectively reviewed in patients with pathology-proved OSSN from January, 1994 to December, 2014. Clinicopathologic correlation was analyzed. Read More

Zhonghua Yan Ke Za Zhi 2018 Sep;54(9):652-660

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100005, China.

To study the histopathology manifestation and imaging characteristics of confocal microscopy (IVCM) for diagnosis of ocular surface squamous neoplasia (OSSN) and analyze the reliability of IVCM in differential diagnosis from OSSN cases. A prospective study. Twenty-three patients (23 eyes) with OSSN were collected from September 2015 to November 2017 in Beijing Tongren Eye center. Read More

Cancer Metastasis Rev 2018 12;37(4):677-690

The New York Eye Cancer Center, Suite 5B, 115 East 61st Street, New York, NY, 10065, USA.

Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Read More

Dermatol Clin 2018 Oct 16;36(4):439-449. Epub 2018 Aug 16.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria Alle Scotte Hospital, Viale Bracci 16, Siena 53100, Italy.

This article describes the present literature on dermoscopy of conjunctiva and shows the results of a dermoscopy study of 147 conjunctival tumors. Melanomas were characterized by a heavy pigmentation, irregular dots, and a higher prevalence of gray color compared with nevi. Squamous cell carcinomas had peculiar hairpin and glomerular vessels. Read More

Eye Contact Lens 2018 09;44 Suppl 1:S374-S375

Ocuoplasty and Ocular Oncology Services, Dr. R.P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Plast Reconstr Surg 2018 11;142(5):818e-819e

Royal Prince Alfred Hospital Westmead Clinical School, Westmead and, Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney and Department of Head and Neck Surgery, Chris O'Brien Lifehouse Cancer Centre Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney, Department of Head and Neck Surgery, Chris O'Brien Lifehouse Cancer Centre, and Department of Plastic Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Int J Ophthalmol 2018 18;11(7):1132-1138. Epub 2018 Jul 18.

Department of Surgery (Ophthalmology), King Hussein Cancer Centre (KHCC), Amman 11941, Jordan.

Aim: To evaluate the features and outcome of management of malignant conjunctival squamous tumors in King Hussein Cancer Center (a referral tertiary cancer center in the Middle East).

Methods: Retrospective case series of 31 eyes for 31 patients with conjunctival squamous neoplasia. Main outcome measures included: age, gender, laterality, tumor location, pathological features, tumor stage, treatment modality, and outcome. Read More

Cornea 2018 Oct;37(10):1292-1298

Ophthalmic Plastics, Orbit and Ocular Oncology Services, Operation Eye Sight Universal Institute for Eye cancer, L V Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, India.

Purpose: To evaluate the imaging characteristics of intraepithelial and invasive ocular surface squamous neoplasia (OSSN) on high-resolution anterior segment optical coherence tomography (ASOCT).

Methods: In this prospective cross-sectional study, 17 consecutive patients (10 intraepithelial and 7 invasive) with histopathologically proven OSSN were included. All patients underwent slit-lamp imaging and time-domain ASOCT at premarked sites. Read More

Br J Ophthalmol 2018 Jun 28. Epub 2018 Jun 28.

Department of Histopathology, National Specialist Ophthalmic Pathology Service (NSOPS), Royal Hallamshire Hospital, Sheffield, UK.

Purpose: To present the clinical and histological features of squamous cell carcinoma (SCC) in the anophthalmic socket in four adult patients, and to determine the presence of human papillomavirus infection (HPV).

Methods: Retrospective case series of four adult patients with SCC of the anophthalmic socket. P16 immunohistochemistry and HPV testing was carried out in all cases. Read More

Rom J Morphol Embryol 2018 ;59(1):375-380

Department of Surgery (Dental and Oro-Maxillo-Facial Surgery), "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;

The invasive conjunctival squamous cell carcinoma (SCC) of the eyeball is a malignant tumor that invades only the conjunctiva and rarely the eyeball and the tissue of the orbit. We presented the clinical case of a 91-year-old patient, hospitalized at the 2nd Ophthalmology Clinic of the "Prof. Dr. Read More

Ecancermedicalscience 2018 15;12:835. Epub 2018 May 15.

Ophthalmic Oncology Department, National Institute of Neoplastic Diseases (INEN), Lima 15038, Peru.

Introduction: In ocular conjunctival carcinoma after surgery, adjuvant treatment has a role and kilovoltage surface brachytherapy opens a new door for the range of therapeutic options.

Materials And Methods: Between October 2014 and June 2017, at the National Institute of Neoplastic Diseases (INEN) from Peru, 39 patients with squamous cell carcinoma of ocular conjunctiva, T1-T3, resected, were selected to receive adjuvant treatment. The portable accelerator of 50-kV INTRABEAM (Carl Zeiss Meditec) was used, after local anaesthesia and blocking of ocular muscles movement. Read More

Rev Fac Cien Med Univ Nac Cordoba 2017 12 14;74(4):402-404. Epub 2017 Dec 14.

Instituto de Oftalmología Conde de Valenciana.

The squamous cell carcinoma of the conjunctiva is a neoplasia of the ocular surface that may present with different macroscopic patterns. We present the case of a 75-year-old man that comes presenting this tumor for a long time, involving in an important way its vision. Read More

J Dermatol 2018 Dec 4;45(12):e346-e347. Epub 2018 Jun 4.

Department of Dermatology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

Cornea 2018 Oct;37(10):1287-1291

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH.

Purpose: To evaluate the clinical relevance of the American Joint Committee on Cancer (AJCC) classification in the initial management of squamous neoplasia of the conjunctiva.

Methods: This retrospective study enrolled 95 histopathologically proven cases of treatment-naive conjunctival squamous neoplasia. Tumors were classified into 4 histological groups: conjunctival intraepithelial neoplasia (CIN) with mild dysplasia (grade 1/3), moderate dysplasia (grade 2/3), severe dysplasia (grade 3/3 or carcinoma in situ), and invasive squamous cell carcinoma (SCC). Read More

Arch Pathol Lab Med 2018 Jun;142(6):706-710

From the Department of Pathology, West Virginia University School of Medicine, Morgantown.

Context: - Human papillomavirus (HPV) has a well-known role in the pathogenesis of squamous cell carcinoma and precursor lesions of the cervix, anogenital region, and head and neck, but its role in the development of squamous neoplasms of the eye, particularly the conjunctiva, remains unclear.

Objective: - To review recent evidence implicating HPV in the pathophysiology of ocular lesions.

Data Sources: - Published articles obtained from a PubMed search of the English literature were the primary sources for this review. Read More

J Contemp Brachytherapy 2018 Apr 30;10(2):174-177. Epub 2018 Apr 30.

Chair and Department of Cancer Pathology and Prophylaxis, Poznan University of Medical Sciences and Greater Poland Cancer Center, Poznan, Poland.

The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctival squamous cell carcinoma (SCC). In 2013, a 73-year-old man presented with a tumor blocking the angle and infiltrating corneal endothelium. The patient was treated with iridectomy, and after one month, ruthenium brachytherapy was applied. Read More

J Fr Ophtalmol 2018 May 16;41(5):412-420. Epub 2018 May 16.

Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.

Introduction: Surgical excision of large malignant lower eyelid tumors may cause important full-thickness eyelid defects. The reconstruction of such defects must restore the physiologic function of the eyelid and also re-establish an acceptable aesthetic result.

Materials And Methods: We report the outcomes of full-thickness excision of tumors extending over half of the horizontal lid length, followed by reconstruction using a nasal chondromucosal graft (coming from the ipsilateral ala of the nose) and an upper eyelid myocutaneous flap. Read More

J Craniofac Surg 2018 Jun;29(4):1017-1019

Department of Plastic Reconstructive and Aesthetic Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

The anterior and posterior lamellae should be simultaneously reconstructed to repair the upper and lower eyelid's full thickness defects after resection of a malignant tumor. The author described a gingivoalveolar mucosal graft for posterior lamellar reconstruction of the lower eyelid. Between November 2014 and September 2017, 11 patients (6 women, 5 men; mean age 62. Read More

Nepal J Ophthalmol 2017 07;9(18):160-169

Introduction: The conjunctiva is a thin and flexible mucus membrane that provides a protective barrier for the eye. Very few histopathologic studies have been conducted on biopsies from conjunctival lesions (CL) in central India.

Objective: To study the spectrum of CL and define those lesions that need attention with regard to need of biopsy in order to prevent grave sequelae and ocular morbidity. Read More

J Med Radiat Sci 2018 Sep 25;65(3):240-244. Epub 2018 Mar 25.

Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

This case study discusses the use of superficial radiotherapy (SXRT) in the treatment of recurrent conjunctival squamous cell carcinoma (SCC). Conjunctival SCC is often an aggressive cancer, with surgery the current standard of care. There is currently limited literature on alternative treatment options to treat conjunctival SCC recurrences that enable ocular function preservation. Read More

J Transl Med 2018 03 21;16(1):77. Epub 2018 Mar 21.

Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", via Mariano Semmola, 80131, Naples, Italy.

Background: Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HIV on the occurrence of telomerase reverse transcriptase (TERT) promoter mutations among a cohort of conjunctiva neoplasia Ugandan patients.

Methods: Telomerase reverse transcriptase promoter mutations were searched in 72 conjunctiva neoplasia cases, comprising SCC and intraepithelial neoplasia grade 1-3 (CIN1-3), as well as in 53 conjunctiva normal tissues and in 24 HIV-related Kaposi sarcoma. Read More

Am J Dermatopathol 2018 Jul;40(7):486-490

Departments of Pathology and Genomic Medicine, and.

Background: Human papillomavirus (HPV) is a causative agent for intraepithelial squamous neoplasms, particularly on mucosal surfaces. HPV has a well-established association with squamous cell carcinoma (SCC) of the oropharynx and genital tract, and recent studies suggest a potential role in ocular and periocular squamous neoplasms. Multiple high-risk HPV genotypes are associated with histologically similar squamous neoplasms, and some HPV genotypes have been differentially associated with high- or low-grade lesions. Read More

Appl Immunohistochem Mol Morphol 2018 07;26(6):e70-e76

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Conjunctival squamous cell carcinoma (SCC) is the most common tumor of conjunctival epithelium. It is associated with risk of permanent visual impairment and has the capability to recur, metastasize, and cause death. Deregulation of cell cycle control has been reported in a number of malignancies. Read More