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Graefes Arch Clin Exp Ophthalmol 2021 May 29. Epub 2021 May 29.

Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, Osaka, 545-8585, Japan.

Purpose: Conjunctival squamous cell carcinoma (SCC) is primarily treated with surgical resection. SCC has various stages, and local recurrence is common. The purpose of this study was to investigate thrombospondin-1 expression and its association with prognosis. Read More

Ocul Oncol Pathol 2021 Mar 11;7(2):77-84. Epub 2021 Jan 11.

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Background: Separately, cryotherapy and brachytherapy have shown promising results when adjuvating the excision of squamous cell carcinoma of the conjunctiva (SCCC). The aim of this paper is to assess the combined effect in terms of complications and recurrence rate.

Summary: We describe 2 patients suffering from SCCC, and we review the current literature on adjuvant cryotherapy and brachytherapy. Read More

Am J Ophthalmol 2021 Apr 22;229:120-126. Epub 2021 Apr 22.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Purpose: To characterize the clinical and histopathologic features of actinic granuloma of the conjunctiva.

Design: Retrospective observational case series METHODS: Institutional pathology records between 2014 and 2020 were searched for all cases of conjunctival actinic granuloma. Information collected included age, sex, ocular and medical history, clinical findings, laboratory workup, treatment, follow-up, pathologic diagnosis, and histopathologic inflammation pattern. Read More

Ocul Oncol Pathol 2021 Mar 21;7(2):108-120. Epub 2021 Jan 21.

Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

Aim: This study aimed to characterize the clinical and pathologic presentation of ocular surface tumors (OSTs) and to more precisely differentiate the grades of ocular surface squamous neoplasia (OSSN) and benign lesions among Zambians.

Methods: Two-hundred sixty-five Zambian patients presenting with ocular surface growths, suspicious for OSSN, were recruited between November 2017 and November 2019 to a cross-sectional study to investigate their lesions. Sociodemographic data were collected, HIV infection status and vision tests were performed, and lesions were measured and documented. Read More

Acta Ophthalmol 2021 Mar 26. Epub 2021 Mar 26.

Ophthalmoplasty Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Sunlight-induced p53 mutations are known to contribute towards increased risk of ocular surface squamous neoplasia (OSSN). Stratifin (14-3-3σ)/HEM (human epithelial marker) is a p53-mediated inhibitor of cell cycle progression and has been shown to be a target of epigenetic deregulation in various carcinomas. In the present study, Stratifin expression, its promoter methylation status as well as expression of mutant p53 in early and advanced AJCC stages (8th edition) of OSSN, was evaluated. Read More

Can J Ophthalmol 2021 Mar 11. Epub 2021 Mar 11.

Institut Curie, Service d'oncologie oculaire, Paris, France.

Objective: To evaluate the outcomes of orbital exenteration with temporalis muscle flap repair of the socket and secondary healing of the anterior surface of the flap in ocular, conjunctival, and eyelid malignancies.

Design: Retrospective single-centre study.

Participants: Consecutive patients who underwent total exenteration for malignancy with temporal muscle flap repair of the socket between December 2009 and January 2016. Read More

J Craniofac Surg 2021 Mar-Apr 01;32(2):e114-e116

Department of Neuroscience, and Reproductive Sciences and Odontostomatology, Maxillofacial Surgery, Section.

Purpose: The aim of this study was to report management and outcomes of patients in which conjunctival carcinomas arose in the anophthalmic socket.

Methods: The authors retrospectively analyzed the data of patients which presented the anophthalmic socket after surgery. The clinical records of 4 patients with histological diagnosis of conjunctival carcinoma in the anophthalmic socket, referred to our Department, between January 2014 and December 2019 was collected. Read More

Eur J Ophthalmol 2021 Mar 4:1120672121999993. Epub 2021 Mar 4.

Istituto di Patologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Primary malignant epithelial tumours arising from accessory lacrimal glands (ALGs) are extremely rare, with only few cases reported in literature. They generally appear as gradually increasing masses of the upper or the lower eyelid. Only one case of primary adenocarcinoma or adenocarcinoma not otherwise specified (ACNOS) from ALGs has been reported in literature. Read More

J Clin Pathol 2021 Feb 22. Epub 2021 Feb 22.

Pathology and Cell Biology, and Ophthalmology, Morsani College of Medicine, Tampa, Florida, USA

Conjunctival squamous intraepithelial neoplasia (CSIN) represents the in situ precursor of squamous cell carcinoma. The graded severity of intraepithelial dysplasia is considered a measure of risk for progression to invasive carcinoma. The range of cytoarchitectural changes in CSIN overlaps those of reactive atypia, squamous epithelial papilloma and in situ sebaceous carcinoma. Read More

BMJ Case Rep 2021 Feb 19;14(2). Epub 2021 Feb 19.

Ophthalmology, Universidad Autonoma de Bucaramanga, Bucaramanga, Santander, Colombia.

A man with a history of blind eye due to trauma 22 years earlier consulted at 53 years of age with a large conjunctival neoplastic lesion, compromising almost the entire temporal limbus, and reaching a size of approximately 16 mm on its larger diameter, in the conjunctiva. Management was started with topical and subconjunctival chemotherapy (interferon alpha-2b) in order to perform immunoreduction, but a dramatic response with total disappearance of the lesion was observed. In the follow-up time period of more than 7 years, there were no signs of recurrence. Read More

Indian J Ophthalmol 2021 03;69(3):563-567

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: The aim of this study was to evaluate tumor control of OSSN with topical IFNα2b alone based on tumor configuration (flat versus (vs.) dome-shaped).

Methods: Retrospective, nonrandomized, interventional cohort study on 64 consecutive tumors in 63 patients with OSSN treated with topical IFNα2b. Read More

BMC Res Notes 2021 Feb 9;14(1):56. Epub 2021 Feb 9.

Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.

Objective: Human papillomavirus (HPV) gained momentum as a potential etiological factor for many types of cancers. Therefore, the aim of this study was to assess the prevalence of HPV-16 infection among Sudanese patients diagnosed with Squamous Cell Carcinoma (SCC) and Salivary Gland Carcinoma. A descriptive, hospital-based study was conducted. Read More

Cancers (Basel) 2021 Jan 26;13(3). Epub 2021 Jan 26.

Department of Radiotherapy, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Peru.

A retrospective study was performed to assess the outcomes of a single-fraction adjuvant electronic brachytherapy (e-BT) approach for patients with squamous cell conjunctival carcinoma (SCCC). Forty-seven patients with T1-T3 SCCC were included. All patients underwent surgery followed by a single-fraction adjuvant e-BT with a porTable 50-kV device. Read More

Asia Pac J Ophthalmol (Phila) 2021 Jan-Feb 01;10(1):130-131

Department of Ophthalmology, Garcia de Orta Hospital, Almada, Portugal.

Arq Bras Oftalmol 2020 Nov-Dec;83(6):505-510

Ophthalmology and Visual Sciences Department, Universidade Federal de São Paulo, Brazil.

Purpose: To evaluate the safety and 12-month effect of treatment with pattern scanning laser photocoagulation for ocular surface squamous neoplasia in a low-resource setting with extremely limited access to an operating room.

Methods: Adult patients with a clinical diagnosis of ocular surface squamous neoplasia underwent a complete ophthalmologic examination. After topical anesthesia and instillation of toluidine blue 1%, the lesion was treated using pattern scanning photocoagulation for a duration time that varied from 20 to 100 ms and power from 600 to 1,800 mW. Read More

Eye (Lond) 2021 Jan 19. Epub 2021 Jan 19.

Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Purpose: To assess margins and the rate of local recurrence of ocular surface squamous neoplasia after excision with a 2 mm margin and cryotherapy at a single ophthalmic oncology center.

Outcome Measures: (1) Conjunctival margin were assessed as positive, negative, or indeterminate margins. (2) Feasibility of repair without a graft. Read More

MMW Fortschr Med 2021 01;163(1):28-29

FA f. Innere Medizin, München, Deutschland.

Ophthalmic Plast Reconstr Surg 2021 Jan-Feb 01;37(1):95-96

Ophthalmic Plast Reconstr Surg 2021 Jan-Feb 01;37(1):95

Int Ophthalmol 2021 Apr 4;41(4):1301-1307. Epub 2021 Jan 4.

Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To identify morphological parameters aiding clinical differentiation of conjunctival intraepithelial neoplasia (CIN) and invasive squamous cell carcinoma (iSCC) and to demonstrate the utility of image processing software to objectively assess ocular surface squamous neoplasia (OSSN).

Methods: This retrospective case series included all biopsy-proven cases of OSSN presenting as an ocular surface nodule. Based on histopathology, lesions were classified as CIN and iSCC. Read More

Curr Opin Infect Dis 2021 Feb;34(1):1-7

National Cancer Registry, National Health Laboratory Service.

Purpose Of Review: Historically, conjunctival cancer has been associated with HIV particularly in sub-Saharan Africa. The human papilloma virus (HPV) has been implicated as a potential causative agent without conclusive evidence. This review covers recent evidence of the epidemiology, diagnosis and treatment of conjunctival cancer in people living with HIV (PLWH). Read More

Ophthalmic Plast Reconstr Surg 2020 Dec 9. Epub 2020 Dec 9.

Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.

Purpose: To describe how a vertical lid split helps excision and reconstruction of conjunctival tumors.

Methods: All patients with a limited view of conjunctival tumors involving the fornices underwent a vertical lid split procedure to improve access during resection and reconstruction.

Results: There were 11 cases where vertical lid splits were performed to assist excision and reconstruction of conjunctival tumors on patients between 2015 and 2019. Read More

Sci Rep 2020 12 4;10(1):21292. Epub 2020 Dec 4.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.

Recent advances in the field of biomedical research allow for elucidation of the transcriptional signature of rare tumors such as conjunctival squamous cell carcinoma (SCC). In this study we compare its expression profile to conjunctival papilloma (Pap) and healthy conjunctival tissue (Ctrl) and develop a classification tool to differentiate these entities. Seven conjunctival SCC, seven Pap and ten Ctrl were formalin-fixed and paraffin-embedded (FFPE) and analyzed using Massive Analysis of cDNA Ends (MACE) RNA sequencing. Read More

Acta Ophthalmol 2020 Nov 16. Epub 2020 Nov 16.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Purpose: We aimed to study the prevalence of human papillomavirus (HPV) in conjunctival intraepithelial neoplasia and carcinoma. Furthermore, we aimed to explore whether geographical differences or different detection modalities are associated with the conflicting information regarding HPV and the development of the disease.

Methods: We searched the MEDLINE, EMBASE and Scopus databases for studies reporting on HPV and conjunctival intraepithelial neoplasia or carcinoma. Read More

Orbit 2020 Nov 12:1-2. Epub 2020 Nov 12.

Department of Plastic Surgery, Queen Elizabeth Hospital, Birmingham, UK.

Pyogenic granuloma (PG) is a common vascular anomaly affecting the skin with occasional involvement of mucosa. Ophthalmic surgeons typically encounter these lesions as solitary, bright red, rapidly growing papules following surgery or trauma to the conjunctiva, e.g. Read More

BMJ Case Rep 2020 Nov 9;13(11). Epub 2020 Nov 9.

Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Primary corneal neoplasia (PCN) is a rare cancerous lesion of cornea usually encountered in elderly. The clinical symptoms are generally non-specific, with ocular irritation, redness, cosmetic disfigurement and varying degrees of visual disturbances depending on visual axis involvement. Corneal neoplasia is usually associated with surrounding conjunctival lesions and incidentally detected PCN is rarely encountered in clinical practice. Read More

Indian J Ophthalmol 2020 Nov;68(11):2491-2492

Kanupriya Dalmia Ophthalmic Pathology Laboratory, MTC Campus, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

J Coll Physicians Surg Pak 2020 Sep;30(9):970-973

Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan.

Objectives: To find out the demography, clinical behaviour and outcome of ocular surface squamous neoplasia (OSSN) in North-west Pakistan.

Study Design: Case series.

Place And Duration Of Study: Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan, from March 2011 to December 2017. Read More

Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):262-268

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: Information regarding risk of metastasis and disease-related death (DD) from conjunctival squamous cell carcinoma (SCC) is relatively scarce. We explored prognostic factors for orbital exenteration, local recurrence, nodal metastasis, and DD in patients with conjunctival SCC.

Design: Retrospective cross-sectional study. Read More

Ophthalmology 2021 Jun 29;128(6):947-950. Epub 2020 Sep 29.

Université Côte d'Azur, Hôpital Pasteur 2, Centre Hospitalier Universitaire de Nice, Service d'Ophtalmologie, Nice, France.