8,554 results match your criteria Squamous Cell Carcinoma* Dermatology

TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1.

Dis Markers 2022 15;2022:3771711. Epub 2022 Jun 15.

Clinical Medical College, Guizhou Medical University, Guiyang 550004, China.

Objective: To explore the effect and potential mechanism of T-LAK cell-originated protein kinase (TOPK) on autophagy in cutaneous squamous cell carcinoma (cSCC).

Methods: Human cSCC cancer tissue and paracancerous tissue samples were collected clinically; immunohistochemistry was used to detect the expression of TOPK, nuclear factor B p65 (NF-B p65), phosphorylated nuclear factor B inhibitor (p-IB), Beclin-1, and microtubule-associated protein 1 light chain 3 (LC3) in cSCC tissue; and immunofluorescence was adopted to detect the coexpression of NF-B p65, p-IB, and TOPK in cSCC tissue. After TOPK silencing or overexpression, SCL-1 and A431 cells were treated with PDTC and 3-MA, respectively. Read More

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A Case Report of a Cutaneous Mucinous Reaction Associated with Erlotinib Therapy Used in the Treatment of Metastatic Tonsillar Sinus Squamous Cell Carcinoma.

J Immunother Precis Oncol 2020 Feb 13;3(1):31-33. Epub 2019 Dec 13.

Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cutaneous mucinoses are a diverse group of diseases that are occasionally seen in the context of an adverse drug reaction. We report the case of a 59-year-old male who presented with an asymptomatic, acneiform rash on his forehead, scalp, nose, upper chest, and upper back that had developed after treatment with erlotinib therapy used in the treatment of metastatic tonsillar sinus squamous cell carcinoma. Biopsy of these lesions demonstrated atypical histology that had features of both follicular mucinosis and myxedema. Read More

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February 2020

Value of Permanent Pathology for Debulk and Mohs Specimens during Mohs Micrographic Surgery for Cutaneous Squamous Cell Carcinoma: A Retrospective Cohort Study.

J Am Acad Dermatol 2022 Jun 23. Epub 2022 Jun 23.

Department of Dermatology, University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd, 4th Floor, Suite 100, Dallas, 75390-9191.

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Real-time, In Vivo Skin Cancer Triage by Laser-Induced Plasma Spectroscopy Combined with Deep Learning-based Diagnostic Algorithm.

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Human-Computer Interaction, Hanyang University, Seoul, South Korea.

Background: Although various skin cancer detection devices have been proposed, most of them are not used owing to their insufficient diagnostic accuracies. Laser-induced plasma spectroscopy (LIPS) can noninvasively extract biochemical information of skin lesions using an ultrashort pulsed laser.

Objective: To investigate the diagnostic accuracy and safety of a real-time noninvasive in vivo skin cancer diagnostics utilizing non-discrete molecular LIPS combined with a deep neural network (DNN)-based diagnostic algorithm. Read More

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The landscape of genetic alterations of UVB-induced skin tumors in DNA repair-deficient mice.

Exp Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe, Japan.

Non-melanoma skin cancer (NMSC) is mainly caused by ultraviolet (UV)-induced somatic mutations and is characterized by UV signature modifications. Xeroderma pigmentosum group A (Xpa) knockout mice exhibit extreme UV-induced photo-skin carcinogenesis, along with a photosensitive phenotype. We performed whole-exome sequencing (WES) of squamous cell carcinoma (SCC) samples after repetitive ultraviolet B (UVB) exposure to investigate the differences in the landscape of somatic mutations between Xpa knockout and wild-type mice. Read More

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In-transit metastasis of cutaneous squamous cell carcinoma: report of two cases.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):75-77

Department of Dermatology and Venereology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Transit metastases include metastatic foci of the skin and subcutaneous tissue located between the tumor and the nearest regional lymph node. Although transit metastases have been described for malignant melanoma, some cases of transit metastases have also been reported among primary cutaneous non-melanoma cancers. Treatment of patients with in-transit squamous cell carcinoma (SCC) is a multimodal approach for advanced staging imaging and therapy, including Mohs micrographic surgery, adjuvant radiation, and possibly sentinel lymph node biopsy and immunotherapy or chemotherapy. Read More

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Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis.

J Pers Med 2022 Jun 16;12(6). Epub 2022 Jun 16.

State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.

Psoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of the exact pathogenesis of these diseases, and Yes-associated protein (YAP), a member of the Hippo signaling pathway, is believed to play an important role. Psoriasis and skin tumors are characterized by excessive cell proliferation, abnormal differentiation, vasodilation, and proliferation. Read More

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Assessment of Serum Urea, Creatinine and Uric Acid in Oral Cancer.

J Clin Med 2022 Jun 16;11(12). Epub 2022 Jun 16.

Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Background: Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide, leading to significant disease-associated social and financial burdens. The investigation of underlying mechanisms involved in carcinogenesis and tumor progression in OSCC might provide new therapeutic perspectives with an impact on disease control and patient survival. Our study aims to investigate the interrelation between metabolic processes, expressed through final catabolism products and clinicopathological characteristics in OSCC. Read More

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Identifying Candidates for Immunotherapy among Patients with Non-Melanoma Skin Cancer: A Review of the Potential Predictors of Response.

J Clin Med 2022 Jun 11;11(12). Epub 2022 Jun 11.

Dermatology Clinic, Maggiore Hospital, University of Trieste, 34125 Trieste, Italy.

Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together with rarer cutaneous cancers, such as Merkel cell carcinoma (MCC) and other forms of adnexal cancers. The majority of NMSCs can be successfully treated with surgery or radiotherapy, but advanced and metastatic stages may require systemic approaches such as immunotherapy with immune checkpoint inhibitors (ICIs).

Summary: Since immunotherapy is not effective in all patients and can potentially lead to severe adverse effects, an important clinical question is how to properly identify those who could be suitable candidates for this therapeutic choice. Read More

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Non-Melanoma Skin Cancer Clearance after Medical Treatment Detected with Noninvasive Skin Imaging: A Systematic Review and Meta-Analysis.

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Dermatologic Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Background/objectives: Non-melanoma skin cancer (NMSC) treated with nonsurgical therapies can be monitored with noninvasive skin imaging. The precision of dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in detecting clearance is unclear. We aim to report the proportion of persisting tumors identified with noninvasive technologies available in the literature. Read More

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Construction of a four-mRNA prognostic signature with its ceRNA network in CESC.

Sci Rep 2022 Jun 23;12(1):10691. Epub 2022 Jun 23.

Department of Oncology, Quzhou Kecheng Hospital, 172 Shuanggang Road, Quzhou, 324000, China.

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) tumorigenesis involves a combination of multiple genetic alteration processes. Constructing a survival-associated competing endogenous RNA (ceRNA) network and a multi-mRNA-based prognostic signature model can help us better understand the complexity and genetic characteristics of CESC. In this study, the RNA-seq data and clinical information of CESC patients were downloaded from The Cancer Genome Atlas. Read More

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New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application.

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:38-50

Dermatology Unit, University of Campania, Naples, Italy.

The incidence of non-melanoma skin cancer is on the rise and melanoma is among the most common cancers in the United States. Establishing an early diagnosis is essential for improving the prognosis of patients with skin cancer. High-resolution non-invasive imaging techniques may represent key tools for helping to identify and monitor early signs of skin cancer in seemingly healthy skin. Read More

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A Distinctive Histological Form of Squamous Cell Carcinoma With Perineural Invasion.

Cureus 2022 May 18;14(5):e25111. Epub 2022 May 18.

Dermatology, Eastern Virginia Medical School, Norfolk, USA.

A modest proportion of individuals diagnosed with squamous cell carcinoma (SCC) display perineural invasion (PNI), the neoplastic invasion of one or more nerves. It is associated with a marked increase in mortality in patients with SCC and is oftentimes only diagnosed after a significant invasion occurs. An 84-year-old male, otherwise in good health, presented to us with a fast-growing, 3-cm nodule on his right malar region associated with paresthesia and radiating pain. Read More

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Tuberous sclerosis and risk of skin cancer: a nationwide cohort study in the United States.

J Am Acad Dermatol 2022 Jun 18. Epub 2022 Jun 18.

Department of Dermatology, Stanford University School of Medicine, Stanford, California. Electronic address:

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Melanoma survivors are at increased risk for second primary keratinocyte carcinoma.

Int J Dermatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Background: Recent large cohorts have reported that melanoma survivors are at risk of developing second keratinocyte carcinoma (KC). However, the detailed proportion and risk are still unknown. We aimed to comprehensively analyze the risk of developing keratinocyte carcinoma after primary melanoma. Read More

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EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.

Nat Commun 2022 Jun 20;13(1):3535. Epub 2022 Jun 20.

Department of Radiation Oncology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.

Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squamous cell carcinoma (HNSCC) and within its microenvironment using genetically engineered mice, recombinant constructs, pharmacologic agonists and antagonists. We observe that manipulating the EphB4 intracellular domain on cancer cells accelerates tumor growth and angiogenesis. Read More

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Comment on "Guidelines of care for the management of actinic keratosis".

J Am Acad Dermatol 2022 Jun 17. Epub 2022 Jun 17.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322. Electronic address:

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Characteristics and management of skin cancers in very elderly patients: A real-world challenge for clinicians.

Exp Dermatol 2022 Jun 20. Epub 2022 Jun 20.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

The increase life expectancy led to an expected increase in skin cancer incidence in older patients. Their treatment can require a complex decision-making process. Limited data are available on characteristics, management and outcome of skin tumours in nonagenarian and centenarian patients. Read More

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A Case of Smooth Muscle Actin-Positive Cutaneous Spindle Cell Squamous Cell Carcinoma.

Ann Dermatol 2022 Jun 20;34(3):230-232. Epub 2022 May 20.

Department of Dermatology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.

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Surgery combined with photodynamic therapy vs. surgery alone for the treatment of non-melanoma skin cancer and actinic keratosis: a retrospective cohort study.

Dermatol Ther 2022 Jun 18:e15652. Epub 2022 Jun 18.

Department of Pathology, Panzhihua Central Hospital, Panzhihua, Sichuan Province, China.

Background: Photodynamic therapy (PDT) is an effective treatment for some non-melanoma skin cancers (NMSC) and actinic keratosis.

Objectives: To compare recurrence-free survival (RFS) rates between surgery alone and surgery with postoperative PDT in patients with NMSC in China.

Methods & Materials: This retrospective cohort study included patients with pathologically confirmed NMSC or actinic keratosis treated by surgical excision with/without PDT. Read More

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Mammalian Target of Rapamycin Inhibitors for prolonged secondary prevention of non-melanoma skin cancer in solid organ transplant recipients.

Dermatol Ther 2022 Jun 18:e15649. Epub 2022 Jun 18.

Devision of Dermatology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Background: Immunosuppressive agents are essential for graft survival in solid-organ transplant recipients (SOTRs), but they have substantial durable side effects, including a higher incidence of aggressive non-melanoma skin cancers (NMSCs). Hitherto, only one class of immunosuppressants, mammalian target of rapamycin inhibitors (mTORi), may inhibit skin tumor formation, however their durable effectiveness is controversial.

Objective: To evaluate the sustained effectiveness of mTORi in reducing NMSCs' incidence in SOTRs. Read More

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Acitretin Enhances the Cytotoxic Effect of 5-aminolevulinic Acid Photodynamic Therapy on Squamous Cell Carcinoma Cells.

Photodiagnosis Photodyn Ther 2022 Jun 14:102969. Epub 2022 Jun 14.

Department of Dermatology, Institute of Dermatology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China, 518036. Electronic address:

The efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) on invasive cutaneous squamous cell carcinoma (cSCC) remains to be improved due to the limited penetration of this treatment. Previous study showed that acitretin and ALA-PDT had synergistic effect on cSCC, but whether acitretin can enhance the cytotoxic effect of ALA-PDT on cSCC is unclear.

Objective: To investigate whether acitretin can enhance the cytotoxic effect of ALA-PDT on SCL-1 cells, as well as the possible mechanism involved. Read More

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Invasive squamous-cell carcinoma in Jorge Lobo's disease: Report of two cases and review of the literature.

Med Mycol Case Rep 2022 Sep 20;37:13-16. Epub 2022 May 20.

Service of Dermatology, Department of Dermatopathology, Federal University of Para (UFPA), Av. Generalíssimo Deodoro, 805 APT-302, CEP: 66050-160, Nazaré, Belem, Para, Brazil.

Jorge Lobo's disease is a chronic granulomatous cutaneous-subcutaneous mycosis caused by the fungus , seen mainly in tropical and subtropical regions. Malignant transformation rarely occurs in this infection. In the present manuscript, we report two cases of Jorge Lobo's disease complicated by invasive squamous cell carcinoma: a 67-year-old man with a 26 -year history of Jorge Lobo's disease. Read More

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September 2022

Skin cancers under Janus kinase inhibitors: A World Health Organization drug safety database analysis.

Therapie 2022 May 7. Epub 2022 May 7.

Dermatology Department, Grenoble Alpes University Hospital, Hôpital Michallon Site Nord BD de la Chantourne, 38700 La Tronche, France.

Background: Janus kinase (JAK) inhibitors are targeted therapies with a potential imunomodulatory and anti-inflammatory effect, indicated in various dysimmune pathologies. Skin cancers have been reported to occur in patients treated with JAK inhibitors. However, drug safety in clinical trials did not confirm that risk, but these studies are performed on controlled population and in a limited time of follow up. Read More

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The Effect of Tumor Characteristics and Location on the Extent of Lymph Node Metastases of Head and Neck Cutaneous Squamous Cell Carcinoma.

Front Oncol 2022 30;12:874295. Epub 2022 May 30.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Background: The extent of a neck dissection for patients with metastasis of cutaneous squamous cell carcinoma of the head and neck (HNcSCC) is still subject to debate and clear guidelines are lacking. Tumor characteristics like size, differentiation and tumor location are known risk factors for lymph node metastasis (LNM). There is some evidence that, depending on tumor location, LNM follows a specific pattern. Read More

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RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer.

J Virol 2022 Jun 15:e0056622. Epub 2022 Jun 15.

Department of Pathology, Johns Hopkins Universitygrid.21107.35, Baltimore, Maryland, USA.

The family of human papillomaviruses (HPV) includes over 400 genotypes. Genus α genotypes generally infect the anogenital mucosa, and a subset of these HPV are a necessary, but not sufficient, cause of cervical cancer. Of the 13 high-risk (HR) and 11 intermediate-risk (IR) HPV associated with cervical cancer, genotypes 16 and 18 cause 50% and 20% of cases, respectively, whereas HPV16 dominates in other anogenital and oropharyngeal cancers. Read More

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Discoid Lupus Erythematosus-Associated Cutaneous Squamous Cell Carcinoma in Systemic Lupus Erythematosus.

Eurasian J Med 2022 Jun;54(2):204-205

Ataturk University School of Medicine, Aesthetic, Plastic and Reconstructive Surgery, Erzurum, Turkey.

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Finding the right help in the tumor microenvironment.

J Clin Invest 2022 Jun;132(12)

Department of Immunology.

Tumor-infiltrating lymphocytes (TILs) contain substantial numbers of CD4+ T cells mediating pro- and antitumor functions. While CD4+ Tregs are well characterized and known to promote tumor immune evasion, the fingerprint of CD4+ Th cells that recognizes tumor antigens and serves to restrict disease progression has remained poorly discriminated. In this issue of the JCI, Duhen et al. Read More

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