6,411 results match your criteria Squamous Cell Carcinoma* Dermatology


Squamous cell carcinoma-related antigen 2 level is a reliable indicator of severe psoriasis involving the face.

G Ital Dermatol Venereol 2019 Jun;154(3):374-375

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China -

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http://dx.doi.org/10.23736/S0392-0488.17.05738-8DOI Listing

lncRNA TINCR participates in ALA-PDT-induced apoptosis and autophagy in cutaneous squamous cell carcinoma.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, People's Hospital of Henan Province, Zhengzhou, Henan, China.

This study aims to investigate whether terminal differentiation-induced ncRNA (TINCR) has an effect on apoptosis and autophagy induced by ALA-PDT in cutaneous squamous cell carcinoma (CSCC). A431 cells were treated with 5-aminolevulinic acid (ALA) solution at different concentrations and for different duration time. A431 cell viability was detected by Cell Counting Kit-8 (CCK-8) assay, relative TINCR messenger RNA expression was detected by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1002/jcb.28662DOI Listing

Prevalence, Discontinuation Rate, and Risk Factors for Severe Local Site Reactions with Topical Field Treatment Options for Actinic Keratosis of the Face and Scalp.

Medicina (Kaunas) 2019 Apr 4;55(4). Epub 2019 Apr 4.

Department of Infectiology and Dermatology, Riga Stradiņš University, Riga, LV-1006, Latvia.

Actinic keratoses (AKs) are common lesions on chronically sun damaged skin, which are morphologically characterized by lower third to full thickness atypia of epidermal keratinocytes. These lesions carry a risk of progression towards invasive squamous cell carcinoma (SCC); therefore, treatment of visible lesions and the field in case of field cancerization is recommended. Treatment of AK includes the destruction of atypical keratinocytes that clinically presents with various degrees of erythema, scaling, crusting, erosion, and other visible and subjective symptoms. Read More

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http://dx.doi.org/10.3390/medicina55040092DOI Listing
April 2019
1 Read

Dermatomyositis associated with adenocarcinoma of the lung: A case report.

J Family Med Prim Care 2019 Feb;8(2):754-756

Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.

The association of dermatomyositis and underlying malignancies, especially small cell and squamous cell carcinoma of the lung, has been recognized a long time ago. We report the case of a 63-year-old male chronic smoker with adenocarcinoma lung associated with dermatomyositis. The occurrence of dermatomyositis should be considered as a potential presentation of paraneoplastic syndromes and physicians encountering similar clinical situations should perform extensive diagnostic work-up to exclude underlying neoplastic lesions. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_467_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436299PMC
February 2019
1 Read

Well-differentiated Squamous Cell Carcinoma Arising in Syringocystadenoma Papilliferum.

Indian Dermatol Online J 2019 Mar-Apr;10(2):168-170

Department of Pathology, AIIMS, Bhopal, Madhya Pradesh, India.

Syringocystadenoma papilliferum (SCAP) is a hamartoma of apocrine sweat gland origin, occurring predominantly in children, in the head and neck region. SCAP can arise or coexist with both benign and malignant tumors. We report herein an extremely rare case of squamous cell carcinoma (SCC) arising in SCAP growth located in unusual supragluteal region in an elderly Indian male. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_43_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434754PMC
April 2019
2 Reads

Chronic Arsenicosis: Cases from a Nonendemic Area of South Rajasthan.

Indian J Dermatol 2019 Mar-Apr;64(2):164

Department of Dermatology, Rajmata Vijaya Raje Scindia Government Medical College, Bhilwara, Rajasthan, India.

Two adult patients from a village of district Bhilwara, Rajasthan, consulted Skin Department of R. N. T. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/164/254170
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http://dx.doi.org/10.4103/ijd.IJD_704_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440183PMC
April 2019
3 Reads

Revised Mohs surgery care guidelines for squamous cell carcinoma in-situ are overdue.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

University of California Irvine, Department of Dermatology, Irvine, California.

The treatment of cutaneous squamous cell carcinoma in situ by Mohs micrographic surgery is currently deemed as appropriate by the Mohs Appropriate Use Criteria. However, squamous cell carcinoma in situ is a very superficial, indolent, low-risk tumor amenable to destructive and non-surgical treatments. It is uncommon for squamous cell carcinoma in situ to have progressed to invasive malignancy subsequent to definitive management. Read More

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March 2019
1 Read

CD100-Plexin-B1 induces Epithelial-Mesenchymal Transition of head and neck squamous cell carcinoma and promotes metastasis.

Cancer Lett 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD100) is highly increased in serum of HNSCC patients, and sCD100 markedly induces the epithelial-mesenchymal transition (EMT) of HNSCC through its receptor, Plexin-B1 (PlxnB1), and promotes the metastasis in a xenograft mouse model. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.04.013DOI Listing
April 2019
1 Read

Integrating the concept of field cancerization in the classification and risk assessment of cutaneous squamous cell carcinoma: proposal for a new classification and terminology of keratinocyte skin cancer.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

The term keratinocyte skin cancer (KC) stands as an umbrella for different stages within the progression of cutaneous squamous cell carcinoma (cSCC). Its earliest form is named actinic keratosis (AK), while for the in-situ form different synonyms, namely intraepidermal carcinoma (IEC), Bowen's Diseases (BD) and cutaneous squamous cell carcinoma in situ [cSCC(Tis)] or intraepithelial squamous cell carcinoma (iSCC) are used. Instead, cSCC is histopathologically classified into well, moderately and poorly differentiated subtypes. Read More

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http://dx.doi.org/10.1111/jdv.15624DOI Listing
April 2019
1 Read

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

CentroDerm GmbH, Heinz-Fangman-Straße 57, Wuppertal, Germany.

Background: Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).

Objective: To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive SCCs.

Methods: All samples were histologically evaluated. Read More

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http://dx.doi.org/10.1111/jdv.15615DOI Listing
April 2019
2 Reads

Performance of the American Joint Committee on Cancer Staging Manual, 8th Edition vs the Brigham and Women's Hospital Tumor Classification System for Cutaneous Squamous Cell Carcinoma.

JAMA Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Brigham and Women's tumor classification (BWH) better predicts poor outcomes than American Joint Committee on Cancer (AJCC) 7th edition (AJCC 7). AJCC 8th edition (AJCC 8) has not been evaluated.

Objectives: To compare BWH and AJCC 8 tumor classifications for head and neck cutaneous squamous cell carcinoma (HNCSCC). Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.0032DOI Listing
April 2019
2 Reads

Upregulated circular RNA circ_0070934 facilitates cutaneous squamous cell carcinoma cell growth and invasion by sponging miR-1238 and miR-1247-5p.

Biochem Biophys Res Commun 2019 Apr 6. Epub 2019 Apr 6.

Department of Dermatology, Heilongjiang Provincial Hospital, Harbin, 150000, China. Electronic address:

Accumulating studies have appreciated circular RNAs (circRNAs) as novel prognostic biomarkers and therapeutic targets in malignant carcinomas. Here, we aim to investigate the expression of a novel circRNA, circ_0070934. The biological roles and mechanisms of circ_0070934 in cutaneous squamous cell carcinoma (CSCC) were explored. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.017DOI Listing

Case-Control Study of Tumor Stage-Dependent Outcomes for Cutaneous Squamous Cell Carcinoma in Immunosuppressed and Immunocompetent Patients.

Dermatol Surg 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, Tufts Medical Center, Boston, Massachusetts.

Background: Immunosuppressed patients have worse outcomes from cutaneous squamous cell carcinomas (cSCCs), although unclear whether it is due to the development of more high-stage tumors or worse outcomes for a given stage.

Objective: Analyze the impact of immunosuppression on the development of cSCCs and tumor stage-dependent outcomes.

Materials And Methods: Single-institution 1:2 case-control study of primary invasive cSCCs from 2005 to 2015 in 106 mixed-cause immunosuppressed patients and 212 control subjects matched to age, gender, and race. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001930DOI Listing

Advanced Ulcerated Squamous Cell Carcinoma of the Hand with Locoregional Axillary Lymph Node Metastasis - Case Report and Literature Review.

Open Access Maced J Med Sci 2019 Mar 14;7(5):791-793. Epub 2019 Mar 14.

Center for Physical and Rehabilitative Medicine, Städtisches Klinikum Dresden, Dresden, Germany.

Background: Cutaneous squamous cell carcinoma (SCC) of the hand is the most common soft-tissue malignancy in this particular region. A literature survey suggested a higher rate of metastases in advanced SCC of the hand compared to head-and-neck cutaneous SCC.

Case Report: An 84-year-old man presented with an ulcerated firm tumour on the dorsum of his right hand. Read More

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http://dx.doi.org/10.3889/oamjms.2019.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447345PMC
March 2019
1 Read

Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

Arch Dermatol Res 2019 Apr 6. Epub 2019 Apr 6.

Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.

The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there are little data about LLT1 expression in human solid tumors. Read More

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http://dx.doi.org/10.1007/s00403-019-01916-xDOI Listing

Reflectance Confocal Microscopy made easy: the four must-know key features for the diagnosis of melanoma and non-melanoma skin cancers.

J Am Acad Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia, Reggio Emilia, Italy.

Background: Reflectance confocal microscopy (RCM)-based skin cancer diagnosis requires proficiency.

Aims: To identify a shortlist of key RCM features of skin cancers and test their diagnostic utility.

Methods: We identified key RCM features through consensus among six experts using a modified-Delphi method. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.085DOI Listing

Overexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma.

Anticancer Res 2019 Apr;39(4):1849-1857

Department of Dermatology, Yanbian University Hospital, Yanji, P.R. China

Background/aim: Melanoma-associated antigen A12 (MAGEA12) has recently been reported as a repressor of tumor-suppressor genes. This study aimed to investigate the implications of MAGEA12 expression in the pathogenesis of cutaneous squamous cell carcinoma (cSCC).

Materials And Methods: MAGEA12 and p21 expression were investigated in 15 samples of normal skin and 111 of cSCC tissues by immunohistochemistry. Read More

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http://dx.doi.org/10.21873/anticanres.13292DOI Listing

Combined the simple shaving with photodynamic therapy for refractory Bowen disease.

Photodiagnosis Photodyn Ther 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Xiangya <-- -->Hospital, Central South University, 87, Xiangya Road, Changsha, 41008, Hunan, China. Electronic address:

Bowen Disease (BD), also known as squamous cell carcinoma in situ, requires actively treatments. Photodynamic therapy (PDT) has been widely recommended to treat for BD. However, there are still a few BD patients with poor efficacy and recurrence after PDT treatment. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.001DOI Listing

SOX-10 Staining in Dermal Scars.

J Cutan Pathol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX.

Background: Positive staining of SOX10 and the S100 protein are often used in the evaluation of challenging melanocytic neoplasms including melanoma in patient samples. SOX-10 positivity of non-melanocytes in re-excsion specimen could complicate the evaluation of invasive melanoma, with an invasive desmoplastic component. Therefore, quantifiable data regarding the positivity of SOX-10 in scars will help dermatopathologists better identify false positive staining. Read More

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http://dx.doi.org/10.1111/cup.13468DOI Listing
April 2019
1.560 Impact Factor

Photodynamic therapy: A hot topic in dermato-oncology.

Oncol Lett 2019 May 16;17(5):4085-4093. Epub 2019 Jan 16.

Department of Dermatology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Photodynamic therapy (PDT) is a modern, non-invasive therapeutic method used for the destruction of various cells and tissues. It requires the simultaneous presence of three components: a photosensitizer (PS), a light source and oxygen. Precancerous skin lesions are conditions associated with a high likelihood of malignant transformation to squamous cell carcinoma. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.9939
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http://dx.doi.org/10.3892/ol.2019.9939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444307PMC
May 2019
3 Reads

Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate.

JCI Insight 2019 Apr 4;4(7). Epub 2019 Apr 4.

Department of Medical Microbiology and Immunology and.

Actinic keratosis (AK) is a precancerous skin lesion that is common in HIV-positive patients. Without effective treatment, AKs can progress to squamous cell carcinoma. Ingenol mebutate, a PKC agonist, is a US Food and Drug Administration-approved (FDA-approved) topical treatment for AKs. Read More

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http://dx.doi.org/10.1172/jci.insight.126027DOI Listing
April 2019
2 Reads

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study.

Dermatology 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.

Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.

Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Read More

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http://dx.doi.org/10.1159/000496539DOI Listing
April 2019
4 Reads

Aberrant expression and high-frequency mutations of in nonmelanoma skin cancer.

Exp Ther Med 2019 Apr 12;17(4):2746-2756. Epub 2019 Feb 12.

Department of Dermatology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518100, P.R. China.

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) have exhibited a marked increase in incidence in previous decades and are the most common malignancies in Caucasian populations. Src homology 3 and multiple ankyrin repeat domains protein-associated RH domain-interacting protein (SHARPIN) has been identified as a commonly overexpressed proto-oncogene in several types of visceral cancer. However, to the best of our knowledge, the functions of SHARPIN in nonmelanoma skin cancer (NMSC) have not been described. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7261
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http://dx.doi.org/10.3892/etm.2019.7261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434243PMC
April 2019
7 Reads

Immunotherapy in non-melanoma skin cancer: updates and new perspectives.

Drugs Context 2019 25;8:212583. Epub 2019 Mar 25.

Department for Dermatology, Venerology and Allergology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.7573/dic.212583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434981PMC
March 2019
5 Reads

Cell Type-Specific p38δ Targeting Reveals a Context-, Stage-, and Sex-Dependent Regulation of Skin Carcinogenesis.

Int J Mol Sci 2019 Mar 27;20(7). Epub 2019 Mar 27.

Department of Anatomy & Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Ross Hall 550, Washington, DC 20037, USA.

Activation and/or upregulated expression of p38δ are demonstrated in human skin malignancies including cutaneous squamous cell carcinoma, suggesting a role for p38δ in skin carcinogenesis. We previously reported that mice with germline deletion of the p38δ gene are significantly protected from chemical skin carcinogenesis. Here, we investigated the effects of cell-selective targeted ablation of p38δ in keratinocytes and in immune (myeloid) cells on skin tumor development in a two-stage 7,12-dimethylbenz()anthracene (DMBA)/12--tetradecanoylphorbol-13-acetate (TPA) chemical mouse skin carcinogenesis model. Read More

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http://dx.doi.org/10.3390/ijms20071532DOI Listing

Apigenin restores impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B radiation.

J Photochem Photobiol B 2019 Mar 21;194:84-95. Epub 2019 Mar 21.

Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China. Electronic address:

Ultraviolet (UV)-B radiation is a major environmental risk factor that is responsible for the development and progression of many skin cancers. Apigenin, a type of bioflavonoid, has been reported to inhibit UVB-induced skin cancer. However, how apigenin functions in keratinocytes with UV damage remains unclear. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.010DOI Listing
March 2019
2 Reads
2.960 Impact Factor

From actinic keratosis to squamous cell carcinoma - answers to some open questions.

Authors:
J Welzel

Br J Dermatol 2019 Apr;180(4):699-700

Department of Dermatology, University Hospital Augsburg, Sauerbruchstrasse 6, 86179, Augsburg, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17637
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http://dx.doi.org/10.1111/bjd.17637DOI Listing
April 2019
4 Reads

USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1.

Cell Death Dis 2019 Apr 1;10(4):296. Epub 2019 Apr 1.

Guangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, No.56 Hengfu Road, Guangzhou, 510095, Guangdong, China.

Previous studies have revealed that dysregulation of long non-coding RNAs (lncRNAs) can facilitate carcinogenesis. This study aims to investigate the biological role of a certain lncRNA in cutaneous squamous cell carcinoma (CSCC). According to the data of TCGA database, high expression of long intergenic non-protein coding RNA 1048 (LINC01048) is an unfavorable prognostic factor for patients with CSCC. Read More

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http://dx.doi.org/10.1038/s41419-019-1516-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443651PMC
April 2019
1 Read
5.014 Impact Factor

Nail Squamous Cell Carcinoma: A Hidden High-risk HPV Reservoir for Sexually Transmitted Infections.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer and oropharyngeal cancer. SCC in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia (PIN) and vulvar intraepithelial neoplasia (VIN), respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.070DOI Listing
March 2019
2 Reads

Non-Melanoma Skin Cancer Tumor's Characteristics and Histologic Subtype as a Predictor for Subclinical Spread and Number of Mohs Stages required to Achieve Tumor-Free Margins.

P R Health Sci J 2019 Mar;38(1):40-45

Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

Objective: To describe the behavior of non-melanoma skin cancer (NMSC) based on tumor's characteristics.

Methods: A total of 219 of NMSC were analyzed via a retrospective medical chart review. The data obtained from each record included but was not limited to: number of Mohs micrographic surgery (MMS) stages required for tumor clearance, defect size, repair type and size according to the neoplasm's histopathologic subtype. Read More

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March 2019
4 Reads

Giant squamous cell carcinoma of the cheek.

Pan Afr Med J 2018;31:59. Epub 2018 Sep 27.

Department of Dermatology, Military Hospital Mohamed V, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2018.31.59.15850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431420PMC

Daylight PDT: patient willingness to undertake home treatment.

Br J Dermatol 2019 Mar 28. Epub 2019 Mar 28.

The Scottish Photodynamic Therapy Centre, Ninewells Hospital, Dundee, U.K.

In the UK, almost one in four individuals over 60 are affected by actinic keratoses (AK), and this is a cause of significant morbidity in an ageing population, with risk of progression to squamous cell carcinoma. Daylight photodynamic therapy (dPDT) is an effective and simple treatment for field change AK, with similar efficacy to conventional PDT. Commonly, skin surface preparation is performed in a Dermatology clinic prior to dPDT. Read More

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http://dx.doi.org/10.1111/bjd.17920DOI Listing

Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling.

Mol Cancer Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado.

TP63 is frequently amplified or overexpressed in primary head and neck squamous cell carcinomas (HNSCC). Nevertheless, the role of TP63 in the initiation and progression of HNSCCs is not known. Using archival HNSCC tissue sections, we found that TP63 expression is often downregulated in late-stage human HNSCCs. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1355DOI Listing

Genome-wide association studies and polygenic risk scores for skin cancer: clinically useful yet?

Br J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Cancer Biology and Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH.

Background: Genome-wide association studies (GWAS) have identified thousands of susceptibility variants, though most have been associated with small individual risk estimates that offer little predictive value. However, combining multiple variants into polygenic risk scores (PRS) may be more informative. Multiple studies have developed PRS composed of GWAS-identified variants for cutaneous cancers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17917
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http://dx.doi.org/10.1111/bjd.17917DOI Listing
March 2019
5 Reads

A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy.

Exp Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa-shi, 272-8513, Chiba, Japan.

Desmoglein (DSG) 3 is overexpressed in oral squamous cell carcinoma (OSCC). Epidermal growth factor receptor (EGFR) inhibitor cetuximab is widely used for OSCC treatment. Several evidences suggest a correlation between DSG3 and EGFR in epidermal keratinocytes. Read More

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http://dx.doi.org/10.1111/exd.13920DOI Listing
March 2019
1 Read

Serum SCCA levels in patients suffering cancers or other diseases.

Prog Mol Biol Transl Sci 2019 9;162:165-175. Epub 2019 Mar 9.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Increased serum squamous cell carcinoma antigen (SCCA) levels are clinically used diagnostic or prognostic biomarker for squamous cell carcinomas. According to recently published studies, increased serum SCCA levels are also observed in adenocarcinomas, hepatocarcinomas, kidney, and other inflammatory diseases, indicating squamous cell carcinoma is not the production source of serum SCCA in these diseases. However, serum SCCA levels in patients suffering different types of diseases have not been systematically measured and compared. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18771173183015
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http://dx.doi.org/10.1016/bs.pmbts.2018.12.004DOI Listing
March 2019
7 Reads

Liposomal Avicequinone-B formulations: Aqueous solubility, physicochemical properties and apoptotic effects on cutaneous squamous cell carcinoma cells.

Phytomedicine 2019 Feb 18;58:152870. Epub 2019 Feb 18.

Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:

Background: Avicequinone-B (Naphtho[2,3-b]furan-4,9-dione) is a furanonaphthoquinone derivative. It is a hydrophobic compound with poor aqueous solubility, which may restrict its potential pharmaceutical and biomedical applications.

Purpose: We synthesized different liposomal formulations of Avicequinone-B, and measured their particle size, aqueous solubility, and physicochemical properties. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113193004
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http://dx.doi.org/10.1016/j.phymed.2019.152870DOI Listing
February 2019
4 Reads

The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2019 Mar 21;11(3). Epub 2019 Mar 21.

Department of Otolaryngology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Head and neck squamous cell carcinoma (HNSCC) affects 650,000 people worldwide and has a dismal 50% 5-year survival rate. Recurrence and metastasis are believed the two most important factors causing this high mortality. Understanding the biological process and the underlying mechanisms of recurrence and metastasis is critical to develop novel and effective treatment, which is expected to improve patients' survival of HNSCC. Read More

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http://dx.doi.org/10.3390/cancers11030395DOI Listing

Skin cancer precursor immunotherapy for squamous cell carcinoma prevention.

JCI Insight 2019 Mar 21;4(6). Epub 2019 Mar 21.

Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown.

Methods: We performed a blinded prospective cohort study on participants of a randomized double-blind clinical trial in which a 4-day course of topical calcipotriol plus 5-FU combination was compared to Vaseline plus 5-FU (control) for AK treatment. Read More

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http://dx.doi.org/10.1172/jci.insight.125476DOI Listing
March 2019
2 Reads

Cutaneous Bowen's Disease: an Analysis of 182 Cases according To Age, Sex, and Anatomical Site from an Italian Center.

Open Access Maced J Med Sci 2019 Feb 20;7(4):696-697. Epub 2019 Feb 20.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Bowen's disease (BD), also known as squamous cell carcinoma in situ, is a type of non-melanocytic intraepidermal malignancy characterised by a slowly enlarging erythematous to pink, scaly patch or plaque with irregular and well-demarcated borders. These lesions are usually persistent and progressive; it has been estimated that in general population around 3% to 5% of Bowen's disease transform into invasive squamous cell carcinoma. This report describes our experience with cutaneous BD and assesses the differences found about age, sex and anatomical site. Read More

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http://dx.doi.org/10.3889/oamjms.2019.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420931PMC
February 2019

Giant Bowen's Disease on the Face: Case Report and Review of the Literature.

Open Access Maced J Med Sci 2019 Feb 22;7(4):606-609. Epub 2019 Feb 22.

University Clinic of Dermatology, Ss. Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Giant Bowen's disease is a rare and unusual clinical manifestation. Presenting as extensive scaly erythematous patch or plaque, it gives rise to a wide spectrum of dermatological differential diagnoses.

Case Presentation: We report a patient with giant Bowen's disease on the face that was successfully treated with topical 5 % imiquimod. Read More

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http://dx.doi.org/10.3889/oamjms.2019.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420943PMC
February 2019
2 Reads

Outcomes of Adjuvant Radiotherapy Following Negative Surgical Margins for Cutaneous Squamous Cell Carcinoma.

Dermatol Surg 2019 Mar 15. Epub 2019 Mar 15.

Departments of Dermatology.

Background: The role of adjuvant radiotherapy (ART) for cutaneous squamous cell carcinoma (cSCC) following negative surgical margins is unclear.

Objective: To retrospectively examine the clinical outcomes in a cohort of patients with cSCC who completed ART after Mohs micrographic surgery or wide local excision with negative margins.

Methods And Materials: After the institutional review board approval, a retrospective review was conducted of all patients with cSCC treated in the Mayo Clinic Department of Radiation Oncology from March 10, 1998, through April 26, 2013. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001827DOI Listing

Squamous Cell Carcinoma In Situ With Occult Invasion: A Tertiary Care Institutional Experience.

Dermatol Surg 2019 Mar 15. Epub 2019 Mar 15.

Memorial Sloan Kettering Cancer Center Dermatology Service, New York, New York.

Background: The rate of occult invasive disease within biopsy-proven squamous cell carcinoma in situ (SCCIS) is not well defined.

Objective: To examine the rate of occult invasion in SCCIS.

Methods: An institutional-wide pathology database was retrospectively searched for "squamous cell carcinoma in situ" over a 6-year period, and the treatment modality and final pathology results were analyzed for evidence of invasion. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001841DOI Listing
March 2019
2 Reads

Long-term experience with radiotherapy for the treatment of non-melanoma skin cancer.

J Dermatolog Treat 2019 Mar 20:1-6. Epub 2019 Mar 20.

c Department of Dermatology , Radboud University Medical Center , Nijmegen , Netherlands.

Purpose: In the Netherlands, the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin is increasing dramatically. Radiotherapy is one of the treatment options, especially for the high risk and the irradical excised tumours.

Methods: Retrospectively, the treatment outcome of all patients with BCC or SCC treated with radiotherapy in the period 2000-2013, were reviewed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592099DOI Listing
March 2019
3 Reads

Multiple self-healing palmoplantar carcinoma: An aberrance of the inflammasome.

JAAD Case Rep 2019 Mar 1;5(3):261-263. Epub 2019 Mar 1.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403110PMC
March 2019
1 Read

Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.

Drug Saf 2019 Mar 19. Epub 2019 Mar 19.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Photosensitive drug eruptions are cutaneous adverse events due to exposure to a medication and either ultraviolet or visible radiation. In this review, the diagnosis, prevention and management of drug-induced photosensitivity is discussed. Diagnosis is based largely on the history of drug intake and the appearance of the eruption primarily affecting sun-exposed areas of the skin. Read More

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http://dx.doi.org/10.1007/s40264-019-00806-5DOI Listing
March 2019
8 Reads

Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy.

The role of telomere biology and telomerase activation in skin cancers has been investigated in melanoma and basal cell carcinoma but limited evidence is available for cutaneous squamous cell carcinoma (cSCC). We will review the current knowledge on the role of telomere and telomerase pathway in cSCC pathogenesis. At the somatic level, both long and short telomere lengths have been described in cSCC. Read More

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http://dx.doi.org/10.3390/ijms20061333DOI Listing
March 2019
1 Read

Consensus Guidelines on the Use of Superficial Radiation Therapy for Treating Nonmelanoma Skin Cancers and Keloids.

J Clin Aesthet Dermatol 2019 Feb 1;12(2):12-18. Epub 2019 Feb 1.

Drs. Nestor and Berman are with the Center for Clinical and Cosmetic Research in A ventura, Florida and the Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine in Miami, Florida.

The use of superficial radiation therapy (SRT) has experienced a renaissance for treating nonmelanoma skin cancers (NMSCs) and recurrent keloids; however, published treatment guidelines are lacking. The objective of this work was to provide consensus guidelines on the use of SRT for treating NMSC and recurrent keloids based on a review of the literature and expert opinion. A search of the medical literature was performed to obtain published information on the use of SRT for review. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415702PMC
February 2019

Systemic Immunotherapy for Advanced Cutaneous Squamous Cell Carcinoma.

Curr Treat Options Oncol 2019 Mar 14;20(4):30. Epub 2019 Mar 14.

Department of Dermatology, Saitama Medical University, Morohongo 38, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Opinion Statement: Advanced (i.e., unresectable) cutaneous squamous cell carcinoma (cSCC) is a rare condition with a dismal prognosis. Read More

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http://dx.doi.org/10.1007/s11864-019-0629-2DOI Listing
March 2019
4 Reads

MicroRNA-186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1.

Exp Ther Med 2019 Mar 7;17(3):1930-1938. Epub 2019 Jan 7.

Hanpu Science and Teaching Park, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.

MicroRNAs (miRs), a class of small non-coding RNAs, have been demonstrated to be involved in the development and progression of human malignancies, including cutaneous squamous cell carcinoma (CSCC). miR-186 serves a suppressive role in certain common types of human cancer; however, its exact function in CSCC has not been reported previously. In the present study, the expression of miR-186 was significantly increased in CSCC tissues compared with adjacent non-tumour tissues. Read More

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http://dx.doi.org/10.3892/etm.2019.7154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396005PMC