6,311 results match your criteria Squamous Cell Carcinoma* Dermatology


Inclusion complex of saikosaponin-d with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-skin cancer activity.

Phytomedicine 2018 Nov 8;57:174-182. Epub 2018 Nov 8.

Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:

Background: Saikosaponin-d (SSD) is a triterpene saponin isolated from Bupleurum plants. It has been shown to exhibit antioxidant, anti-inflammatory, and anticancer activities. However, its biomedical applications are limited by its poor water solubility. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.012DOI Listing
November 2018

Dermoscopic Features of Chondrodermatitis Nodularis Chronica Helicis: A Case Series.

Dermatol Pract Concept 2019 Jan 31;9(1):52-53. Epub 2019 Jan 31.

Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Spain.

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http://dx.doi.org/10.5826/dpc.0901a12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368084PMC
January 2019

Keratoacanthomas: A Review of Excised Specimens.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Assistant Professor, Saint Louis University Department of Dermatology, 1755 S Grand Blvd, St. Louis, MO 63104.

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http://dx.doi.org/10.1016/j.jaad.2019.02.011DOI Listing
February 2019
1 Read

Algorithms for ascertaining keratinocyte carcinomas using health insurance claims and prescription records.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Skin Science, University of British Columbia.

Skin cancer is the most common human malignancy with an ongoing continual increase in global incidence. Despite their high prevalence, keratinocyte carcinomas (KCs), namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are often excluded from population-based cancer registries. As there are over 3000 defined skin disease varieties that can be diagnosed, robust ascertainment methods are needed to capture KC cases for epidemiologic purposes. Read More

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http://dx.doi.org/10.1111/jdv.15490DOI Listing
February 2019

Topical kinase inhibitors induce regression of cutaneous squamous cell carcinoma.

Exp Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104.

Actinic keratoses (AKs) and squamous cell carcinoma in situ (SCCIS) are precursor lesions for cutaneous squamous cell carcinoma (cSCC), the second most common form of cancer. Current topical therapies for AKs and SCCIS promote skin inflammation to eradicate lesions and do not directly target the biological mechanisms driving growth. We hypothesized that topical small molecule inhibitors targeting kinases promoting keratinocyte growth in AKs and SCCIS could induce regression of these lesions with less inflammation. Read More

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http://doi.wiley.com/10.1111/exd.13902
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http://dx.doi.org/10.1111/exd.13902DOI Listing
February 2019
4 Reads

[Progress in roles and mechanisms of deacetylase SIRT7].

Sheng Wu Gong Cheng Xue Bao 2019 Jan;35(1):13-26

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways. In addition, SIRT7 is also closely related with aging, heart disease and fatty liver. Read More

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http://dx.doi.org/10.13345/j.cjb.180139DOI Listing
January 2019
1 Read

Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599819829741DOI Listing
February 2019

The NLRP1 inflammasome pathway is silenced in cutaneous squamous cell carcinoma.

J Invest Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, 8006 Zurich, Switzerland. Electronic address:

The inflammasome protein NLRP1 is an important innate immune sensor in human keratinocytes and mediates, together with the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1, the activation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. These cytokines and inflammasomes can have in part opposing roles during tumorigenesis in mice. In contrast, ASC expression is impaired in different types of cancer in humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193010
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http://dx.doi.org/10.1016/j.jid.2019.01.025DOI Listing
February 2019
3 Reads

Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma.

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancers. Several previous studies have shown that Fibulin-3 participates in the occurrence and development of various tumors; however, its role in cSCC remains unknown. In the present study, we observed that the expression of Fibulin-3 was down-regulated in cSCC tissues compared with normal skin tissues, which was due to Fibulin-3 promoter methylation. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.022DOI Listing
February 2019
1 Read

Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma.

Am J Clin Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Stanford University School of Medicine, 450 Broadway Street, Mail Code 5334, Redwood City, CA, 94063, USA.

Cutaneous squamous cell carcinoma (CSCC) is one of the most common human malignancies, and the incidence is increasing with time. High mutational loads, known infiltration with lymphocytes, and programmed death (PD)-ligand 1 (PD-L1) expression suggest that immune checkpoint inhibitors, such as PD-1 inhibitors, may show utility in treating CSCC, similar to response see in other solid tumor types. Recently, the robust responsiveness of CSCCs to the PD-1 inhibitor cemiplimab was revealed in the results of a combined phase I/II clinical trial, with an overall response rate of 50% and a durable response exceeding 6 months in 57% of responders. Read More

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http://link.springer.com/10.1007/s40257-019-00426-w
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http://dx.doi.org/10.1007/s40257-019-00426-wDOI Listing
February 2019
2 Reads

Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

University of Minnesota, Department of Dermatology, 516 Delaware Street S.E., Mail Code 98, Phillips-Wangensteen Bldg., Suite 4-240, Minneapolis, Minnesota 55455.

Pseudocarcinomatous (pseudoepitheliomatous) hyperplasia represents reactive epidermal change mimicking squamous cell carcinoma (SCC), owing to a variety of inflammatory and neoplastic phenomena, including deep fungal infections, CD30-positive lymphomas, and others. We report a case of Sweet syndrome (SS) arising in a patient with acute myelogenous leukemia, with persistent orolabial involvement which mimicked SCC both clinically and microscopically, but resolved entirely with adequate corticosteroid treatment. Clinicians should be aware that neutrophilic dermatoses such as SS and pyoderma gangrenosum may rarely exhibit pseudocarcinomatous epidermal changes similar to those seen in soft tissue infections and other inflammatory dermatoses. Read More

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http://dx.doi.org/10.1111/cup.13436DOI Listing
February 2019
1 Read

Coffee, tea, caffeine, and risk of non-melanoma skin cancer in a Chinese population: The Singapore Chinese Health Study.

J Am Acad Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Health Services and Systems Research, Duke-NUS Medical School, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

Background: While epidemiological studies in populations of European-descent suggest possible chemo-protective effect of caffeine against non-melanoma skin cancer (NMSC), data in Asian populations are lacking.

Objectives: We examined the relations between coffee, tea and caffeine consumption, and NMSC risk among Chinese in Singapore.

Methods: We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women aged 45-74 years at recruitment from 1993 to 1998. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.084DOI Listing
February 2019
1 Read

Cutaneous shrinkage after surgical resection of facial skin tumors: a prospective study on 100 surgical specimens.

Clin Exp Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Aix Marseille University, APHM, Hôpital Nord, Department of Oral and Maxillofacial Surgery, 13015, Marseille, France.

Histological reports of skin tumor excisions frequently describe a lesser margin than the clinical excision margin. This study was aimed to evaluate the degree of shrinkage occurring in facial cutaneous specimens after excision and formalin fixation, and to assess the role of potentially influential factors. Our prospective study on 100 surgical specimens from 06/01/2017 to 10/31/2017 showed a mean shrinkage from in vivo (before excision) to in vitro (after 24h formalin fixation) of 12. Read More

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http://dx.doi.org/10.1111/ced.13945DOI Listing
February 2019

Dermoscopy for the diagnosis of eyelid margin tumours.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France.

There are only case reports concerning dermoscopy of eyelid margin tumours. We evaluated the clinical and dermoscopic features of 165 eyelid margin tumours of 145 consecutive patients (77 females, 68 males, mean age 64·3 years, standard deviation - SD 17·94, range 10 - 95 years) recruited at the Dermatology Department of the University Hospital of Saint-Etienne, France, between September 1st, 2013 and January 30th, 2017 to exclude malignant tumours. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17743
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http://dx.doi.org/10.1111/bjd.17743DOI Listing
February 2019
2 Reads

Study of skin neoplasms in a university hospital: integration of anatomopathological records and its interface with the literature.

An Bras Dermatol 2019 Jan-Feb;94(1):42-46

Service of Dermatology, Hospital Escola Álvaro Alvim, Campos dos Goytacazes (RJ), Brazil.

Background: Skin cancer is a highly prevalent condition with a multifactorial etiology resulting from genetic alterations, environmental and lifestyle factors. In Brazil, among all malignant tumors, skin cancers have the highest incidences.

Objective: To retrospectively evaluate the incidence, prevalence and profile of basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma in Campos dos Goytacazes and region. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360975PMC
June 2017
1 Read

CD103 negative memory T cells may play important roles in making regulatory T cell-enriched environments in skin tumors.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Human skin contains resident memory T cells (T ) and central memory T cells (T ) . T are characterized by CD69 expression and can be divided into 2 subpopulations: CD103 T and CD103 T . Although both T and T showed antitumor efficacy in a mouse model , little is known about their role in human skin cancer. Read More

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http://dx.doi.org/10.1111/jdv.15478DOI Listing
February 2019

Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16.

J Cancer 2019 1;10(2):510-521. Epub 2019 Jan 1.

Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, China.

Lycopene, a kind of carotenoid, has been reported to have an inhibitory function on tumor cell migration. However, the potential role of lycopene in the treatment of cutaneous squamous cell carcinoma (cSCC) remains unclear. Therefore, we assessed the biological effects of lycopene in the human cSCC cell line COLO-16, human epidermal keratinocytes (HEKs) and the immortalized human keratinocyte cell line HaCaT. Read More

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http://dx.doi.org/10.7150/jca.26578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360289PMC
January 2019
2.639 Impact Factor

De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma.

Cell Stem Cell 2019 Jan 31. Epub 2019 Jan 31.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA; New York University School of Medicine, New York, NY, USA. Electronic address:

Basal tumor propagating cells (TPCs) control squamous cell carcinoma (SCC) growth by self-renewing and differentiating into supra-basal SCC cells, which lack proliferative potential. While transcription factors such as SOX2 and KLF4 can drive these behaviors, their molecular roles and regulatory interactions with each other have remained elusive. Here, we show that PITX1 is specifically expressed in TPCs, where it co-localizes with SOX2 and TRP63 and determines cell fate in mouse and human SCC. Read More

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http://dx.doi.org/10.1016/j.stem.2019.01.003DOI Listing
January 2019
1 Read

Understanding roofers' sun protection behaviour: A qualitative study.

J Eur Acad Dermatol Venereol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.

The incidence of keratinocyte carcinoma (KC), which includes squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and actinic keratosis (AK), has steadily increased in the last few decades; moreover, KC is the most common malignancy in Caucasians worldwide. As exposure to solar ultraviolet radiation (UVR) is the main risk factor for KC, outdoor workers bear a high risk for KC. Therefore, SCC and AK were officially recognised as occupational diseases in Germany in 2015. Read More

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http://dx.doi.org/10.1111/jdv.15460DOI Listing
February 2019
1 Read

Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma.

J Invest Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford CA, United States of America. Electronic address:

Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naïve tumors responsiveness to Smoothened inhibitors (Smo), resistance in advanced tumors remains frequent. While the resistant BCCs usually maintain HH pathway activation, squamous cell carcinomas with Ras/MAPK pathway activation also arise, with the molecular basis of tumor type and pathway selection still obscure. Read More

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http://dx.doi.org/10.1016/j.jid.2018.11.035DOI Listing
January 2019

Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFR.

Chin Med J (Engl) 2019 Feb;132(4):454-465

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: Long noncoding RNAs (lncRNAs) play pivotal roles in various malignant tumors. Epidermal growth factor receptor (EGFR) signaling is associated with the pathogenesis of cutaneous squamous cell carcinoma (cSCC). This study aimed to explore the role of LINC00520 in the development of cSCC via EGFR and phosphoinositide 3-kinase-protein kinase B (PI3K/Akt) signaling pathways. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000070DOI Listing
February 2019

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors.

Clin Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Centre of Evidence Based Dermatology, University of Nottingham, King's Meadow Campus, Lenton Lane, Nottingham, UK.

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It presents the key findings from 14 systematic reviews published in 2016, focusing on AE epidemiology, aetiology and risk factors. For systematic reviews on the treatment and prevention of AE and for nomenclature and outcome assessments, see Parts 1 and 3 of this update, respectively. Read More

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http://dx.doi.org/10.1111/ced.13853DOI Listing
January 2019
1 Read

Impressive oral lichen planus progression to invasive squamous cell carcinoma in a three months lapse.

Oral Oncol 2019 Jan 28. Epub 2019 Jan 28.

Dermatology Clinic - Department of Medical Sciences and Public Health, University of Cagliari, Via Ospedale 54, 09124 Cagliari, Italy.

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.029DOI Listing
January 2019

Risk Factors for Keratinocyte Carcinoma Skin Cancer In Nonwhite Individuals: A Retrospective Analysis.

J Am Acad Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA. Electronic address:

Background: As the majority of the U.S. population will consist of nonwhite individuals by the year 2043, it is essential that both physicians and patients are educated about skin cancer in nonwhite individuals. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.038DOI Listing
January 2019
1 Read

Facial distribution of squamous cell carcinoma in Japanese.

Exp Dermatol 2019 Feb;28 Suppl 1:72-74

Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Squamous cell carcinoma (SCC) is a malignant tumor of the skin. SCC is frequently distributed on highly exposed areas such as the face and dorsal surface of the hands because it is closely related to ultraviolet damage. We retrospectively analyzed 106 cases of SCC treated at Nagoya City University Hospital from April 2004 to October 2015 and examined regional features based on modified facial aesthetic units. Read More

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http://dx.doi.org/10.1111/exd.13830DOI Listing
February 2019
3 Reads

Secondary analysis of existing microarray data reveals potential gene drivers of cutaneous squamous cell carcinoma.

J Cell Physiol 2019 Jan 29. Epub 2019 Jan 29.

Division of Plastic and Reconstructive Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Cutaneous squamous-cell carcinoma (cSCC) is the second most common skin cancer, with an increasing incidence in recent years. To define the molecular basis that drive cSCC development and progression, this study aimed at identifying potential novel molecular targets for the diagnosis and therapy of patients with cSCC. Two data sets with the accession number GSE45164 and GSE66359 were downloaded from Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.1002/jcp.28172DOI Listing
January 2019
2 Reads

Vulvar squamous cell carcinoma: a clinico-dermoscopic correlation.

Clin Exp Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Policlinico Sant'Orsola-Malpighi, University of Bologna, Italy.

Squamous cell carcinoma (SCC) is the most common malignant vulvar tumor.1 It primarily affects post-menopausal women; its precursor lesions are vulvar intraepithelial neoplasia (VIN), in particular the "differentiated" subtype, and/or human papillomavirus (HPV) infection.1 The final diagnosis of vulvar SCC is made by histopathology, which is similar to that of SCC affecting other body areas, distinguishing between well differentiated forms and poorly differentiated tumors. Read More

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http://doi.wiley.com/10.1111/ced.13934
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http://dx.doi.org/10.1111/ced.13934DOI Listing
January 2019
4 Reads

Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas.

Cancer Invest 2019 Jan 28:1-12. Epub 2019 Jan 28.

a Department of Dermatology , Kuopio University Hospital, University of Eastern Finland , Kuopio , Finland.

By using immunohistochemistry and antibodies that identify complement C3c (in C3 and C3b) or CD11b receptor, we report that the proportion C3c mast cells and the number of CD11b cells are increased in basal cell carcinoma (BCC). Instead, only CD11b cells are increased in squamous cell carcinoma/Bowen's disease, and only slightly so in actinic keratosis. Only C3c mast cells are increased in psoriasis. Read More

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http://dx.doi.org/10.1080/07357907.2019.1565765DOI Listing
January 2019
1 Read

Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for -altered head and neck cancer.

J Exp Med 2019 Feb 25;216(2):419-427. Epub 2019 Jan 25.

Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA

is the most commonly altered oncogene in head and neck squamous cell carcinoma (HNSCC). We evaluated the impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on survival in a -characterized cohort of 266 HNSCC patients and explored the mechanism in relevant preclinical models including patient-derived xenografts. Among subjects with mutations or amplification, regular NSAID use (≥6 mo) conferred markedly prolonged disease-specific survival (DSS; hazard ratio 0. Read More

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http://www.jem.org/lookup/doi/10.1084/jem.20181936
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http://dx.doi.org/10.1084/jem.20181936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363423PMC
February 2019
21 Reads

Reaccion acneiforme noduloquistica secundaria a vemurafenib con buena respuesta a isotretinoina oralSevere acneiform eruption associated with vemurafenib with response to isotretinoin.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid.

Vemurafenib, a kinase inhibitor that targets tumors with the BRAF V600E mutation, is a promising option for unresectable or metastatic melanoma. Cutaneous side-effects have been reported including alopecia, photosensitivity, squamous cell carcinoma, keratoacanthomas, keratosis pilaris-like eruption, and palmoplantar hyperkeratosis. Acneiform eruptions have been reported in 3%-6% of the patients treated with BRAF inhibitors,and 5 cases are described in the literature. Read More

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August 2018
2 Reads

Dermatology on YouTube - an update and analysis of new trends.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado Dermatology Service, US Department of Veteran Affairs, Eastern Colorado Health Care System, Denver, Colorado.

Because YouTube is one of the most popular search engines, it is an instrumental tool to stay up to date on the most relevant dermatology trends and content in order to better direct patients and improve health outcomes. Twelve select terms (i.e. Read More

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December 2018
6 Reads

Expression of 3q oncogene in atypical fibroxanthoma-immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features.

Oncol Lett 2019 Feb 27;17(2):1768-1776. Epub 2018 Nov 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, D-66421 Homburg, Germany.

Atypical fibroxanthoma (AFX) is a rare mesenchymal tumor with predominance in older male patients located mainly in chronically UV-exposed skin. Differentiation from clinically more aggressive pleomorphic dermal sarcoma (PDS) is still under debate and immunohistochemical markers are not available yet. An immunohistochemical study, including 41 cases of AFX was conducted to investigate the expression of 3q encoded oncogene in AFX and determine the associations with histomorphologic, clinical and viral parameters. Read More

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http://dx.doi.org/10.3892/ol.2018.9767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341582PMC
February 2019
1 Read

Cell phone usefulness to improve the skin cancer screening: preliminary results and critical analysis of mobile app development.

Rural Remote Health 2019 Jan 24;19(1):4895. Epub 2019 Jan 24.

Barretos Cancer Hospital, Street Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos - SP, 14784-400, Brazil

Introduction: The high incidence of skin cancer in Brazil has resulted in an urgent need for more efficient methods of reducing the time between initial diagnosis and therapy. Such delays are significant in large countries like Brazil, where a considerable proportion of the population live in remote areas with limited access to specialized medical care. To address this problem the use of mobile phones as screening devices for suspicious skin lesions has been incorporated as long-distance teledermatology services. Read More

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https://www.rrh.org.au/journal/article/4895
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http://dx.doi.org/10.22605/RRH4895DOI Listing
January 2019
4 Reads

Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant.

JAMA Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology, University of California, San Francisco, San Francisco.

Importance: Risk factors for the development of skin cancer after solid-organ transplant can inform clinical care, but data on these risk factors are limited.

Objective: To study the association between HLA antigen mismatch and skin cancer incidence after solid-organ transplant.

Design, Setting, And Participants: This retrospective cohort study is a secondary analysis of the multicenter Transplant Skin Cancer Network study of 10 649 adults who underwent a primary solid-organ transplant between January 1, 2003, and December 31, 2003, or between January 1, 2008, and December 31, 2008. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4983DOI Listing
January 2019
6 Reads

Cetuximab as a Component of Multimodality Treatment of High-Risk Cutaneous Squamous Cell Carcinoma: A Retrospective Analysis From a Single Tertiary Academic Medical Center.

Dermatol Surg 2019 Feb;45(2):254-267

Departments of Dermatology.

Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and has potential for regional or distant metastasis. Despite the standardization of features associated with high-risk cSCC, an advanced subset of cSCC, there is no established consensus regarding proper management of this tumor.

Objective: To evaluate the efficacy of cetuximab, add to existing management options, and aid in the development of standardized treatment for this tumor. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001755DOI Listing
February 2019

Cutaneous Sarcomatoid Squamous Cell Carcinoma of the Ear and the Use of Immunohistochemical Staining as a Diagnostic Aid.

Dermatol Surg 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, Virginia Commonwealth University Health System, Richmond, Virginia Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia Department of Dermatology, Virginia Commonwealth University Health System, Richmond, Virginia.

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http://dx.doi.org/10.1097/DSS.0000000000001742DOI Listing
January 2019

A case of erosive pustular dermatosis of the scalp in a pediatric patient.

JAAD Case Rep 2019 Feb 11;5(2):118-120. Epub 2019 Jan 11.

Department of Dermatology, University of Texas Medical Branch, Galveston, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330372PMC
February 2019

Diagnostic impact of reflectance confocal microscopy as a second-level examination for facial skin lesions.

J Dtsch Dermatol Ges 2019 Jan 22. Epub 2019 Jan 22.

Department of Dermatology, Medical University of Graz, Graz, Austria.

Background And Objective: Benign and malignant facial skin lesions may be difficult to differentiate clinically and with dermoscopy. The present study aimed to evaluate the potential utility of in vivo reflectance confocal microscopy (RCM) as a second-level examination for facial skin neoplasms.

Patients And Methods: Retrospective and blinded evaluation of 160 consecutive facial lesions was carried out in two separate steps. Read More

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http://doi.wiley.com/10.1111/ddg.13748
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http://dx.doi.org/10.1111/ddg.13748DOI Listing
January 2019
4 Reads

Controlled release of methotrexate from functionalized silica-gelatin aerogel microparticles applied against tumor cell growth.

Int J Pharm 2019 Mar 18;558:396-403. Epub 2019 Jan 18.

Department of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen 4032, Hungary; MTA-DE Redox and Homogeneous Catalytic Reaction Mechanisms Research Group, Egyetem tér 1, H-4032 Hungary. Electronic address:

Methotrexate functionalized silica-gelatin hybrid aerogel (SGM) was synthesized by the sol-gel method and co-gelation. The drug methotrexate (MTX) is covalently linked to the collagen molecules of the hybrid aerogel backbone by amide-bond. The characteristic MTX content of the functionalized hybrid aerogel is ca. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193005
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.024DOI Listing
March 2019
4 Reads

Pembrolizumab resolves adult ashy dermatosis developing in patients with squamous cell carcinoma of the lung.

J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Ashy dermatosis is a rare cutaneous disorder of unknown etiology. We describe a case of adult ashy dermatosis developing in a patient with squamous cell carcinoma of the lung, which was resolved by the administration of pembrolizumab in parallel with multiple vitiligo. Interestingly, immunohistochemical staining revealed that lesional skin of the ashy dermatosis contained cytotoxic T cells and programmed death ligand 1 expressing cells. Read More

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http://dx.doi.org/10.1111/1346-8138.14775DOI Listing
January 2019
1 Read

Trends in the treatment and prevention of keratinocyte carcinoma (non-melanoma skin cancer).

Authors:
Alexander Zink

Curr Opin Pharmacol 2019 Jan 17;46:19-23. Epub 2019 Jan 17.

Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany; Clinical Unit Allergology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany. Electronic address:

Keratinocyte carcinoma (KC), previously also known as non-melanoma skin cancer, is the most common malignancy worldwide. It comprises basal cell carcinoma, squamous cell carcinoma (SCC), and actinic keratoses as carcinoma in situ or precursors of SCC. With solar ultraviolet radiation being the main risk factor, several countries have accepted KC as an occupational disease of outdoor professions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14714892183009
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http://dx.doi.org/10.1016/j.coph.2018.12.002DOI Listing
January 2019
4 Reads

Cytokeratin expression in epidermal stem cells in skin adnexal tumors.

Oncol Lett 2019 Jan 8;17(1):927-932. Epub 2018 Nov 8.

Department of Pathology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

The expression levels of seven types of cytokeratin (CK) in different kinds of skin adnexal tumors were evaluated. One hundred and thirty-two patients with different kinds of skin adnexal tumors admitted and treated in the Department of Dermatology of Dongying People's Hospital from May 2013 to May 2015 were selected and underwent tissue section staining. Another 20 cases of normal skin were enrolled as the control group. Read More

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http://dx.doi.org/10.3892/ol.2018.9679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312935PMC
January 2019
1 Read

Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner.

Mol Cancer Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Loss of the desmosomal cell-cell adhesion molecule, Desmoglein 1 (Dsg1), has been reported as an indicator of poor prognosis in head and neck squamous cell carcinomas (HNSCC) overexpressing epidermal growth factor receptor (EGFR). It has been well established that EGFR signaling promotes the formation of invadopodia, actin-based protrusions formed by cancer cells to facilitate invasion and metastasis, by activating pathways leading to actin polymerization and ultimately matrix degradation. We previously showed that Dsg1 downregulates EGFR/Erk signaling by interacting with the ErbB2-binding protein Erbin (B2 teracting Protein) to promote keratinocyte differentiation. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0048DOI Listing
January 2019
2 Reads

How to Improve Compliance With Dermatologic Screening in Liver Transplant Recipients: Experience in a (Spoke) Peripheral Center for Follow-up.

Transplant Proc 2019 Jan - Feb;51(1):184-186. Epub 2018 Jun 30.

Unit for Liver Transplant Management (SATTE), AORN Sant'Anna e San Sebastiano, Caserta, Italy.

Annual dermatologic examination is required in all transplant recipients because of the high risk of skin cancers. Nevertheless, if the transplant recipient is merely advised to have a dermatologic consultation, the adherence usually appears to be poor. We analyzed our population of liver transplant recipients in 2 periods: in 2014 (group 1) and in 2016 (group 2), when we had organized the presence of a dermatologist at scheduled intervals to annually examine the entire liver transplant population we actively follow-up. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.215DOI Listing
June 2018
1 Read

Non-invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenolmebutate gel 150 mcg/gby means of reflectance confocal microscopy and optical coherence tomography: new perspectives and comparison of diagnostic techniques.

J Biophotonics 2019 Jan 17:e201800391. Epub 2019 Jan 17.

Department of Dermatology and Allergy, University Hospital Munich, Munich, Germany.

Actinic keratosis (AKs) corresponds to the earliest stage of in-situ squamous cell carcinoma and arises on chronically sun-exposed skin. Around the clinically evident AKs, the apparently healthy epidermis may contain different grades of atypia that can be detected by non-invasive imaging techniques such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Subclinical actinic keratosis (sAKs) have captured increasing interest as a potential target of field therapies. Read More

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http://doi.wiley.com/10.1002/jbio.201800391
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http://dx.doi.org/10.1002/jbio.201800391DOI Listing
January 2019
3 Reads

A role for stromal autophagy in cancer-associated fibroblast activation.

Autophagy 2019 Jan 17:1-2. Epub 2019 Jan 17.

a Massachusetts General Hospital , Cutaneous Biology Research Center , Charlestown , MA , USA.

In the tumor stroma, cancer-associated fibroblasts (CAFs) affect all aspects of tumor evolution. Whereas several programs leading to CAF activation have been elucidated, little is known about the impact of the microenvironment on the turnover of key CAF regulators. RBPJ/CSL is a transcriptional repressor that mediates NOTCH signaling and its down-modulation activates the gene expression program(s) leading to stromal senescence and CAF activation. Read More

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http://dx.doi.org/10.1080/15548627.2019.1569936DOI Listing
January 2019
1 Read

Skin Cancer Associated Genodermatoses: A Literature Review.

Acta Derm Venereol 2019 01 17. Epub 2019 Jan 17.

Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense, Denmark.

Skin cancer has become the most common type of cancer worldwide as a result of environmental exposure and medical treatments. A small group of patients are genetically predisposed to skin cancer and this article is intended as a diagnostic tool when encountering patients with multiple skin cancer lesions. The disorders are described with clinical characteristics, genetics and management. Read More

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http://dx.doi.org/10.2340/00015555-3123DOI Listing
January 2019
7 Reads

Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort.

PLoS One 2019 16;14(1):e0210070. Epub 2019 Jan 16.

Cancer Epidemiology Research Program, IDIBELL, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.

Background: Human papillomavirus (HPV) is the cause of a fraction of head and neck squamous cell carcinoma. Although this relation is well-known, it is still not clear the role of HPV in premalignant oral lesions such as oral lichen planus (OLP) and dysplasia. We aimed to evaluate the HPV-DNA prevalence and type distribution in a set of oral biopsies obtained from patients diagnosed with OLP and dysplasia, as well as the role of HPV in these lesions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335078PMC
January 2019
5 Reads