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    Assessment of relationship of ABO blood groups among tobacco induced oral cancer patients of Kanpur Population, Uttar Pradesh.
    J Exp Ther Oncol 2017 Nov;12(2):129-135
    Department of Periodontics, Rama Dental College Hospital and Research Center, Kanpur, 208024, Uttar Pradesh, India.
    Background: The possibility of association between ABO blood groups and malignancy was first discussed by Anderson DE & Haas C. The association between blood group and oral cancer is least explored and hence this study was undertaken to evaluate relationship of ABO blood groups with an increased risk for oral cancer.

    Materials And Method: The present study was conducted at various cancer hospitals in Kanpur. Read More

    Micronuclei assay in exfoliated buccal cells of radiation treated oral cancer patients.
    J Exp Ther Oncol 2017 Nov;12(2):121-128
    Rama Dental College Hospital and Research Centre, Department of Oral and Maxillofacial Pathology, Kanpur 208024, Uttar Pradesh, India.
    Background: Micronuclei are suitable internal dosimeters for revealing tissue-specific genotoxic damage in individuals exposed to carcinogenic mixtures. Evaluation of radiation-induced cellular changes to predict radiosensitivity has invested many investigators since such changes were first found in biopsy material.

    Aim: The aim of the present study was to assess the relationship of with histopathological grade and number of radiation therapy sittings with the frequency of micronuclei and nuclear anomalies among oral cancer patients. Read More

    Highly efficient destruction of squamous carcinoma cells of the head and neck by photochemical internalization of Ranpirnase.
    J Exp Ther Oncol 2017 Nov;12(2):113-120
    Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
    Introduction: Photochemical Internalization is a novel drug delivery technology for cancer treatment based on the principle of Photodynamic Treatment. Using a photosensitizer that locates in endocytic vesicles membranes of tumor cells, Photochemical internalization enables cytosolic release of endocytosed antitumor agents in a site-specific manner. The purpose of the present in-vitro study was to explore whether Photochemical Internalization is able to enhance the efficacy of Ranpirnase, a cytotoxic amphibian ribonuclease, for eradication of squamous cell carcinoma of the head and neck. Read More

    Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis.
    Br J Cancer 2017 Nov 21. Epub 2017 Nov 21.
    Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden.
    Background: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods.

    Methods: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Read More

    Prognostic value of an immunohistochemical signature in patients with esophageal squamous cell carcinoma undergoing radical esophagectomy.
    Mol Oncol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
    Here, we aimed to identify an immunohistochemical (IHC)-based classifier as a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC). A cohort of 235 patients with ESCC undergoing radical esophagectomy (with complete clinical and pathological information) were enrolled in the study. Using the least absolute shrinkage and selection operator (LASSO) regression model, we extracted six IHC features associated with progression-free survival (PFS) and then built a classifier in the discovery cohort (n=141). Read More

    Smoking cessation leads to changes in survivin expression in oral mucosa.
    J Oral Pathol Med 2017 Nov 21. Epub 2017 Nov 21.
    São Paulo State University, Oral Biosciences and Diagnosis, Brazil.
    Background: Survivin is an inhibitor protein of apoptosis and play a role in oral carcinogenesis mechanism.

    Methods: This aim of this study was to evaluate the effect of smoking in survivin expression of oral mucosa of chronic smokers with and without oral squamous cell carcinoma (OSCC). The study was composed of three groups: Group 1 - 26 patients smoking more than 20 cigarettes/day/10 years without either history of oral malignant neoplasia or visible clinical signs in the examined site; Group 2 - 26 patients with OSCC; Group 3 - 22 patients surgically treated for OSCC for at least 1 month. Read More

    Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil.
    J Bras Pneumol 2017 Sep-Oct;43(5):363-367
    . Serviço de Cirurgia Torácica, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS - Porto Alegre (RS) Brasil.
    Objective: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countries.

    Methods: This was a retrospective study of 1,030 patients with NSCLC treated with lung resection between 1986 and 2015 at a university hospital in southern Brazil. Read More

    Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer.
    Otolaryngol Head Neck Surg 2017 Nov 1:194599817742615. Epub 2017 Nov 1.
    3 Department of Head and Neck Surgery, Kaiser Permanente Southern California Medical Group, San Diego, California, USA.
    Objective This study introduces a treatment algorithm based on staging neck dissection to identify patients with palatine tonsil squamous cell carcinoma who can be effectively treated with single-modality transoral robotic surgery while maintaining quality of life. Study Design Retrospective case series. Setting Kaiser Permanente Southern California Medical Group from 2012 to 2017. Read More

    Inhibition of metastasis and angiogenesis in Hep-2 cells by wheatgrass extract - an in vitro and in silico approach.
    Toxicol Mech Methods 2017 Nov 21:1-14. Epub 2017 Nov 21.
    a Department of Biochemistry and Molecular Biology, School of Life Sciences , Pondicherry University , Kalapet , Puducherry , India.
    Metastasis is the major hindrance in the treatment of all cancers, including laryngeal squamous cell carcinoma. Intensive researches are under way to identify the effective natural polyphenols with anti-metastatic ability for cancer treatment. Wheatgrass, an herbal plant has been reported to show anticancer effects. Read More

    Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells.
    J Periodontal Res 2017 Nov 20. Epub 2017 Nov 20.
    Department of Periodontology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
    Background And Objective: Dental calculus is a mineralized deposit attached to the tooth surface. We have shown that cellular uptake of dental calculus triggers nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation, leading to the processing of the interleukin-1β precursor into its mature form in mouse and human phagocytes. The activation of the NLRP3 inflammasome also induced a lytic form of programmed cell death, pyroptosis, in these cells. Read More

    Orbital invasive squamous cell carcinoma with adnexal involvement clinically mimicking feline restrictive orbital myofibroblastic sarcoma: 19 cases (1990-2016).
    Vet Ophthalmol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
    Objective: To describe the clinical presentations of patients diagnosed with ocular adnexal or orbital squamous cell carcinoma (SCC), which possess features similar to feline restrictive orbital myofibroblastic sarcoma (FROMS).

    Procedures: A retrospective review of adnexal and/or orbital SCC was performed. Cases were collected from the University of Georgia College of Veterinary Medicine and the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) (1990-2016). Read More

    Antibodies against human papillomaviruses as diagnostic and prognostic biomarker in patients with neck squamous cell carcinoma from unknown primary.
    Int J Cancer 2017 Nov 21. Epub 2017 Nov 21.
    Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Treatment of patients with neck lymph node metastasis of squamous cell carcinoma (SCC) from unknown primary tumor (NSCCUP) is challenging due to the risk of missing occult tumors or inducing toxicity to unaffected sites. Human papillomavirus (HPV) is a promising biomarker given its causal link to oropharyngeal SCC and superior survival of patients with HPV-driven oropharyngeal SCC and NSCCUP. Identification of HPV-driven NSCCUP could focus diagnostic work-up and treatment on the oropharynx. Read More

    General health-related quality of life scores from head and neck squamous cell carcinoma patients obtained throughout the first year following diagnosis predicted up to 10-year overall survival.
    Eur Arch Otorhinolaryngol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway.
    Objectives: To evaluate the 5- and 10-year survival prediction of health-related quality of life (HRQoL) scores obtained at diagnosis and at 6, 9 and 12 months after diagnosis in a cohort of curable head and neck squamous cell carcinoma (HNSCC) patients.

    Materials And Methods: HNSCC patients (n = 109) reported their HRQoL measured by the EORTC Quality of Life Questionnaire (QLQ) general (C30) questionnaire. At diagnosis, the included patients were below 78 years of age and at diagnosis planned treated with curative intent. Read More

    Comparison of positron emission tomography/computed tomography and magnetic resonance imaging for posttherapy evaluation in patients with advanced cervical cancer receiving definitive concurrent chemoradiotherapy.
    Eur J Nucl Med Mol Imaging 2017 Nov 20. Epub 2017 Nov 20.
    Gynecologic Cancer Research Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
    Purpose: Our purpose was to assess the diagnostic performance of positron emission tomography/computed tomography (PET/CT) and pelvic/abdominal magnetic resonance imaging (MRI) after concurrent chemoradiotherapy (CCRT) for posttherapy evaluation in patients with advanced cervical cancer.

    Methods: Patients with cervical squamous cell carcinoma, either with advanced FIGO stage or with positive pelvic or para-aortic lymph node (PALN), received PET/CT using [(18)F]fluorodeoxyglucose and MRI including diffusion-weighted imaging between 2 and 3 months after CCRT completion. PET/CT were interpreted independently by two nuclear medicine physicians and MRI by two radiologists using the same scoring system. Read More

    A case of pure-type ovarian squamous cell carcinoma producing granulocyte-colony stimulating factor.
    Gynecol Oncol Rep 2017 Nov 4;22:89-91. Epub 2017 Nov 4.
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
    •Pure-type ovarian squamous cell carcinoma (POSCC) is extremely rare.•This is the first report of G-CSF-producing POSCC.•This case was successfully treated with primary surgery and standard chemotherapy. Read More

    Linear Malignant Melanoma In Situ: Reports and Review of Cutaneous Malignancies Presenting as Linear Skin Cancer.
    Cureus 2017 Sep 18;9(9):e1696. Epub 2017 Sep 18.
    Department of Dermatology, University of California, San Diego.
    Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. Read More

    A 16-gene signature predicting prognosis of patients with oral tongue squamous cell carcinoma.
    PeerJ 2017 17;5:e4062. Epub 2017 Nov 17.
    Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
    Background: Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer. A predictive gene signature is necessary for prognosis of OTSCC.

    Methods: Five microarray data sets of OTSCC from the Gene Expression Omnibus (GEO) and one data set from The Cancer Genome Atlas (TCGA) were obtained. Read More

    Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging.
    Case Rep Otolaryngol 2017 12;2017:9647010. Epub 2017 Oct 12.
    Department of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, Japan.
    Background: The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinoma, and, in almost all those cases, carcinoma was detected using positron emission tomography/computed tomography and/or bilateral tonsillectomy. Read More

    Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer.
    Case Rep Oncol Med 2017 12;2017:4276435. Epub 2017 Oct 12.
    Department of Hematology Oncology, SUNY Upstate Medical University, Syracuse, NY 13205, USA.
    Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. Majority of the PTC carries an excellent prognosis. However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant. Read More

    Gastric and Rectal Metastases from Malignant Melanoma Presenting with Hypochromic Anemia and Treated with Immunotherapy.
    Case Rep Oncol Med 2017 12;2017:2079068. Epub 2017 Oct 12.
    Medical Oncology Unit, Dipartimento di Scienze Chirurgiche, Oncologiche e Stomatologiche, University of Palermo, Palermo, Italy.
    The authors present a case of an 80-year-old Caucasian male with multiple gastric and rectal metastases from malignant melanoma presenting with hypochromic anemia as the sole symptom of disease without evidence of cutaneous and ocular tumor localization. The patient had a medical history positive for malignant lentigo melanoma of the occipital region of the scalp and early stage laryngeal squamous cell carcinoma and prostatic carcinoma treated with radiation therapy. The authors make some considerations on intestinal involvement by metastatic melanoma and discuss the choice of not treating with endoscopic procedures the gastric metastatic lesions most likely responsible for the clinical sign present at diagnosis. Read More

    The Prognostic Value of Peripheral Benzodiazepine Receptor in Patients with Esophageal Squamous Cell Carcinoma.
    J Cancer 2017 20;8(16):3343-3355. Epub 2017 Sep 20.
    Department of Anesthesiology, Cancer Center, Sun Yat-Sen University, State Key Laboratory of Oncology in South China, Guangzhou510060, Guangdong, China.
    Background: The peripheral benzodiazepine receptor (PBR) has previously been reported as an oncogene in prostate, breast and colorectal cancers, but its prognostic value, biological behavior and function in esophageal squamous cell carcinoma (ESCC) has not been investigated. Methods: qRT-PCR, western blotting and immunohistochemistry (IHC) were used to detect PBR expression in ESCC and matched non-cancerous tissues. Based on all of the significantly independent factors, a nomogram was established to predict the prognosis of ESCC patients. Read More

    PD-L1 is a Prognostic Biomarker in Resected NSCLC Patients with Moderate/high Smoking History and Elevated Serum SCCA Level.
    J Cancer 2017 15;8(16):3251-3260. Epub 2017 Sep 15.
    Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer.
    Programmed cell death-1 (PD-1) -targeted immunotherapy has become a promising treatment paradigm for patients with advanced non-small cell lung cancer (NSCLC). Clinical responses to checkpoint inhibition therapy in NSCLC have been associated with programmed death-1 ligand 1 (PD-L1) expression. However, the association between the expression of PD-L1 and PD-L2 and the clinicopathological features and patient outcomes in NSCLC remain unclear. Read More

    Radiotherapy Alone or Concurrent Chemoradiation for Esophageal Squamous Cell Carcinoma in Elderly Patients.
    J Cancer 2017 15;8(16):3242-3250. Epub 2017 Sep 15.
    Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 710032 China.
    Purpose: The reported data of elderly ESCC are rather limited and there is a lack of information to guide treatment decisions for elderly patients with esophageal cancer. This study aims to identify the efficacy and factors for optimal treatment approaches for elderly esophageal squamous cell carcinoma (ESCC) treated with radiotherapy (RT) alone or concurrent chemoradiation (CCRT). Methods: This study included 184 I-III elderly ESCC patients aged ≥70 years treated by oral single agent CCRT (sCCRT) or double agents CCRT (dCCRT) or RT alone at a single institution in China. Read More

    Correlation of cancer stem cell markers and immune cell markers in resected non-small cell lung cancer.
    J Cancer 2017 15;8(16):3190-3197. Epub 2017 Sep 15.
    Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academic of Medical Science, Jinan, Shandong, China.
    Background: Recent studies confirmed that immunotherapy showed prominent efficacy in non-small cell lung cancer (NSCLC). Cancer stem cells/cancer initiating cells are resistant to anticancer treatment. The purpose of the study was to analyze the correlation of cancer stem cells/cancer initiating cells and tumor-infiltrating immune cells in NSCLC. Read More

    Mechanisms underlying the antiproliferative effects of a series of quinoxaline-derived chalcones.
    Sci Rep 2017 Nov 20;7(1):15850. Epub 2017 Nov 20.
    Postgraduate Program in Medicine and Health Sciences, PUCRS, Porto Alegre, RS, Brazil.
    The present study aimed to characterize the effects of quinoxaline-derived chalcones, designed on the basis of the selective PI3Kγ inhibitor AS605240, in oral cancer cells. Three lead compounds, namely N9, N17 and N23, were selected from a series of 20 quinoxaline-derived chalcones, based on an initial screening using human and rat squamous cell carcinoma lineages, representing compounds with at least one methoxy radical at the A-ring. The selected chalcones, mainly N9 and N17, displayed marked antiproliferative effects, via apoptosis and autophagy induction, with an increase of sub-G1 population and Akt inhibition. Read More

    Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis and Tumorigenesis in the Mouse Oral Cavity.
    Cancer Prev Res (Phila) 2017 Nov 20. Epub 2017 Nov 20.
    Biochemistry and Molecular Biology, Pennsylvania State University
    We previously showed that metabolic activation of the environmental and tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) to its active fjord region diol epoxide (DB[a,l]PDE) is required to induce DNA damage, mutagenesis and squamous cell carcinoma (SCC) in the mouse oral cavity. In contrast to procarcinogens which were employed previously to induce SCC, DB[a,l]PDE does not require metabolic activation to exert its biological effects and thus, this study was initiated to examine, for the first time, whether black raspberry powder (BRB) inhibits post-metabolic processes such as DNA damage, mutagenesis and tumorigenesis. Prior to long-term chemoprevention studies we initially examined the effect of BRB (5% added to AIN-93M diet) on DNA damage in B6C3F1 mice using LC-MS/MS and on mutagenesis in the lacI gene in the mouse oral cavity. Read More

    Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas.
    Matrix Biol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Dermatology, Faculty of Medicine, Medical Center -, University of Freiburg, University of Freiburg, Germany; Department of Dermatology, Royal Melbourne Hospital, Parkville and Box Hill Hospital - Monash University, Eastern Health Clinical School, Box Hill, Victoria, Australia.
    In this study we used a genetic extracellular matrix (ECM) disease to identify mechanisms associated with aggressive behavior of cutaneous squamous cell carcinoma (cSCC). cSCC is one of the most common malignancies and usually has a good prognosis. However, some cSCCs recur or metastasize and cause significant morbidity and mortality. Read More

    The potential role of leptin in tumor invasion and metastasis.
    Cytokine Growth Factor Rev 2017 Nov 11. Epub 2017 Nov 11.
    The Hormel Institute, University of Minnesota, Austin, MN 55912, United States. Electronic address:
    The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Read More

    Comparison of neoadjuvant chemoradiation with carboplatin/ paclitaxel or cisplatin/ 5-fluoruracil in patients with squamous cell carcinoma of the esophagus.
    Radiat Oncol 2017 Nov 21;12(1):182. Epub 2017 Nov 21.
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, D-81675, Munich, Germany.
    Purpose: Neoadjuvant chemoradiation (nCRT) is the treatment of choice for patients with locally advanced squamous cell carcinoma of the esophagus (SCC). Today radiation oncologists can choose between two different therapy regimes including chemoradiation with cisplatin and 5-fluoruracil (CDDP/5FU) and chemoradiation analogue to the CROSS-regime with carboplatin and paclitaxel (Carb/TAX). However, there is a lack of studies comparing these regimes, especially for the subgroup of patients with SCC. Read More

    Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts.
    J Exp Clin Cancer Res 2017 Nov 21;36(1):163. Epub 2017 Nov 21.
    Departmentof Anatomy, Basic Medical Science College, Harbin Medical University, 194 Xuefu Road, Nangang District, Harbin, 150081, China.
    Background: Oral squamous cell carcinoma (OSCC) invades surrounding tissues by upregulating matrix metalloproteinases (MMPs) -2 and -9, which causes over-expression of the Hedgehog signaling proteins Shh and Gli-1 and degradation of the extracellular matrix, thereby creating a "highway" for tumor invasion. We explored the potential of low intensity ultrasound (LIUS) and doxorubicin (DOX) to inhibit the formation of this "highway".

    Methods: MTT assays were used to examine OSCC cell viability after exposure to LIUS and DOX. Read More

    Separation of cell survival, growth, migration, and mesenchymal transdifferentiation effects of fibroblast secretome on tumor cells of head and neck squamous cell carcinoma.
    Tumour Biol 2017 Nov;39(11):1010428317705507
    Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
    Fibroblasts play a central role in tumor invasion, recurrence, and metastasis in head and neck squamous cell carcinoma. The aim of this study was to investigate the influence of tumor cell self-produced factors and paracrine fibroblast-secreted factors in comparison to indirect co-culture on cancer cell survival, growth, migration, and epithelial-mesenchymal transition using the cell lines SCC-25 and human gingival fibroblasts. Thereby, we particularly focused on the participation of the fibroblast-secreted transforming growth factor beta-1. Read More

    S100A14 rs11548103 G>A polymorphism is associated with a decreased risk of esophageal cancer in a Chinese population.
    Oncotarget 2017 Oct 14;8(49):86917-86923. Epub 2017 Sep 14.
    Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
    Objective: In China in 2009, esophageal cancer was the fifth most commonly diagnosed malignancy and the fourth leading cause of malignancy-related death. Accumulating evidence indicates that genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis.

    Materials And Methods: In total, we recruited 629 ESCC patients and 686 controls. Read More

    Metastatic to negative lymph node ratio demonstrates significant prognostic value in patients with esophageal squamous cell carcinoma after esophagectomy.
    Oncotarget 2017 Oct 28;8(49):86908-86916. Epub 2017 Jul 28.
    Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Clinical Research Center for Cancer of Tianjin City, Tianjin, China.
    Aims: The prognostic value of metastatic lymph node ratio (LNR) has been reported in some studies; however, there is no report on the prognostic significance of metastatic to negative lymph node ratio (MNLNR) in cancer patients. The aim of this study was to compare the prognostic value of pN, LNR and MNLNR on the survival of patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy.

    Methods: The data of 290 patients with ESCC after curative esophagectomy was retrospectively analyzed. Read More

    A three-microRNA signature for lung squamous cell carcinoma diagnosis in Chinese male patients.
    Oncotarget 2017 Oct 28;8(49):86897-86907. Epub 2017 Jul 28.
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China.
    Various studies have demonstrated the diagnostic value of microRNA (miRNA) for lung cancer, but miRNA signatures varied between different subtypes. Whether serum miRNAs could be used as biomarkers in lung squamous cell carcinoma (SCC) remains unknown. Using quantitative real-time polymerase chain reaction (qRT-PCR) based Exiqon panel, 38 differentially expressed miRNAs were identified from 3 male lung SCC pool samples and 1 normal control (NC) pool in the initial screening phase. Read More

    MDM4 genetic variants predict HPV16-positive tumors of patients with squamous cell carcinoma of the oropharynx.
    Oncotarget 2017 Oct 30;8(49):86710-86717. Epub 2017 Sep 30.
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
    The increasing incidence of squamous cell carcinoma of the oropharynx (SCCOP) is majorly attributed to the human papillomavirus (HPV) infection. Both HPV and MDM4 play a critical role in inhibition of p53 activity, thus affecting HPV tumor status of SCCOP. Three polymorphisms in MDM4 were genotyped from blood genomic DNA samples and HPV16 status in tumor specimens was examined. Read More

    HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression.
    Oncotarget 2017 Oct 23;8(49):86410-86422. Epub 2017 Sep 23.
    State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
    Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. Read More

    Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
    Oncotarget 2017 Oct 21;8(49):86369-86383. Epub 2017 Sep 21.
    Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Human cancer cell lines are the most frequently used preclinical models in the study of cancer biology and the development of therapeutics. Although anatomically diverse, human papillomavirus (HPV)-driven cancers have a common etiology and similar mutations that overlap with but are distinct from those found in HPV-negative cancers. Building on prior studies that have characterized subsets of head and neck squamous cell carcinoma (HNSCC) and cervical squamous cell carcinoma (CESC) cell lines separately, we performed genomic, viral gene expression, and viral integration analyses on 74 cell lines that include all readily-available HPV-positive (9 HNSCC, 8 CESC) and CESC (8 HPV-positive, 2 HPV-negative) cell lines and 55 HPV-negative HNSCC cell lines. Read More

    ELAS1 induces apoptotic death in adenocarcinoma DU145 and squamous-cell carcinoma SAS cancer cells, but not in normal KD cells.
    Oncotarget 2017 Oct 24;8(49):85868-85882. Epub 2017 Aug 24.
    Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
    We previously reported that an ELAS1 peptide containing 29 amino acids induces apoptotic death in U2OS human osteosarcoma cells following DNA double-strand break insults. Here, we show that ELAS1 also caused apoptosis in prostate adenocarcinoma DU145 cells and tongue squamous-cell carcinoma SAS cells. ELAS1 appears to be safe because it induced apoptosis only in cancer cells, not in normal KD cells. Read More

    Smoking and gender modify the effect of TWIST on patient survival in head and neck squamous carcinoma.
    Oncotarget 2017 Oct 6;8(49):85816-85827. Epub 2017 Sep 6.
    Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
    Purpose: TWIST is a critical factor for predicting prognosis in several human cancers. Here, we study the prognostic significance of TWIST1 and TWIST2 in Head and Neck squamous cell carcinoma (HNSCC) as well as interactions of TWISTs with both gender and smoking in patient survival.

    Methods: upper quartile normalized RNA-seq V2 RSEM values of TWIST1 and TWIST2 expressions were retrieved from a TCGA HNSCC dataset. Read More

    Telomerase reverse transcriptase mediates EMT through NF-κB signaling in tongue squamous cell carcinoma.
    Oncotarget 2017 Oct 14;8(49):85492-85503. Epub 2017 Sep 14.
    The Base of "111 Project" for Biomechanics and Tissue Repair Engineering, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering college, Life Science College, Chongqing University, Chongqing 400044, China.
    Locoregional lymph nodes metastasis in oral tongue squamous cell carcinoma represents one of important and common prognostic factors for poor clinical outcome. The human Telomerase Reverse Transcriptase (hTERT) is one of key players in cancer metastasis and stemness, but its exact function in tongue squamous cell carcinoma remains unknown. Here, we aim to understand the role of hTERT by utilizing the CRISPR/Cas9 gene editing system to deplete hTERT in the SCC-15 cell line. Read More

    Cancer-associated fibroblasts confer cisplatin resistance of tongue cancer via autophagy activation.
    Biomed Pharmacother 2017 Nov 14;97:1341-1348. Epub 2017 Nov 14.
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:
    Cancer-associated fibroblasts (CAFs) play important roles in carcinogenesis and progression of tongue squamous cell carcinoma (TSCC). However, effect of CAFs on chemotherapy resistance of TSCC remains largely obscure. Here, we cultured the matched primary CAFs and normal fibroblasts (NFs) pairs and detected their roles in cisplatin sensitivity of TSCC, as well as autophagy-related protein LC3 and Beclin1 expressions. Read More

    PD-1 blockade in advanced NSCLC: A focus on pembrolizumab.
    Cancer Treat Rev 2017 Oct 23;62:39-49. Epub 2017 Oct 23.
    Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland. Electronic address:
    Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers and is responsible for a large proportion of all cancer-related deaths. Current treatment options are inadequate, reflecting a substantial unmet clinical need. Increasing knowledge regarding the mechanisms and genetic aberrations underlying tumor development and growth has heralded a new era of therapy in oncology, moving away from indiscriminate cytotoxic chemotherapy toward more finely focused, targeted medicine. Read More

    European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers.
    Eur J Cancer 2017 Nov 16;87:172-181. Epub 2017 Nov 16.
    Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark. Electronic address:
    Aim: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours.

    Patient And Methods: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Read More

    Use of negative pressure wound therapy after infection and flap dehiscence in radical vulvectomy: A case report.
    Int J Surg Case Rep 2017 Nov 6;41:370-372. Epub 2017 Nov 6.
    Multidisciplinary Unit for Abdominal Pelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, Spain, Dept. of Medicine, University Jaume I (UJI), Castellon de la Plana, Spain.
    Introduction: Vulvar cancer has a lower incidence in high income countries, but is rising, in part, due to the high life expectancy in these societies. Radical vulvectomy is still the standard treatment in initial stages. Wound dehiscence contitututes one of the most common postoperative complications. Read More

    Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion.
    PLoS One 2017 20;12(11):e0188322. Epub 2017 Nov 20.
    Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
    Objective: To analyze the clinicopathologic characteristics and prognosis of patients with squamous cell carcinoma localized to different supraglottic subregions.

    Methods: Clinicopathologic data were reviewed retrospectively for 111 patients with supraglottic squamous cell carcinoma who were diagnosed between January 1, 1995 and December 31, 2005 and were initially treated with surgery. DNA from human papillomavirus (HPV) 16 and (or /and) HPV 18 were detected in all the 111 supraglottic carcinoma specimens using in situ hybridization. Read More

    Video Endoscopic Inguinal Lymphadenectomy Versus Open Inguinal Lymphadenectomy for Carcinoma Penis: Expanding Role and Comparison of Outcomes.
    Urology 2017 Nov 16. Epub 2017 Nov 16.
    Professor and unit head, Department of urology and Renal transplantation, SMS Medical college, Jaipur, Rajasthan, India.
    Objective: To compare differences of morbidity profile, oncological yield & efficacy between video endoscopic inguinal lymphadenectomy and open inguinal lymphadenectomy cases.

    Materials And Methods: A total of 29 patients with proven squamous cell carcinoma of penis were selected for inguinal lymphadenectomy from August 2013 to Jan 2017. Video endoscopic lymphadenectomy was performed on one limb and open inguinal lymphadenectomy was performed on the contralateral side. Read More

    Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas.
    Cancer Lett 2017 Nov 15. Epub 2017 Nov 15.
    Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea; Rare Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea; Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea. Electronic address:
    Despite expressing high levels of the epidermal growth factor receptor (EGFR), a majority of oral squamous cell carcinoma (OSCC) patients show limited response to cetuximab and ultimately develop drug resistance. However, mechanism underlying cetuximab resistance in OSCC is not clearly understood. Here, using a mouse orthotopic xenograft model of OSCC, we show that BMP7-p-Smad1/5/8 signaling contributes to cetuximab resistance. Read More

    Association between genetic polymorphisms in the promoters of let-7 and risk of cervical squamous cell carcinoma.
    Gene 2017 Nov 14. Epub 2017 Nov 14.
    Department of Gynecology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin 300100, PR China.
    Numerous reports showed low levels of let-7 family in cervical cancer, acting as tumor suppressors by regulating multiple target genes. Genetic variants in the promoter of miRNA have been reported to influence individuals' susceptibility to human diseases. We aimed to investigate the association of rs10877887 and rs13293512 polymorphisms in the promoters of let-7 with risk of cervical squamous cell carcinoma (CSCC). Read More

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