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    150026 results match your criteria Squamous Cell Carcinoma

    1 OF 3001

    Total FDG lesion number on PET/CT predicts survival of esophageal carcinoma patients with recurrence following curative surgery.
    Q J Nucl Med Mol Imaging 2018 Apr 24. Epub 2018 Apr 24.
    Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea - khnm.lee@
    Background: Total lesion number is a prognostic determinant in recurrent esophageal cancer, but this requires multiple tests. Here, we investigated the prognostic value of total FDG lesion number obtained from a single PET/CT study.

    Methods: Subjects were 153 esophageal squamous cell carcinoma patients with loco-regional or distant recurrence following curative surgery. Read More

    Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer.
    Int J Cancer 2018 Apr 26. Epub 2018 Apr 26.
    Department of Otolaryngology/Head and Neck Surgery, University of Washington School of Medicine, Saint Louis, MO, USA.
    Diets high in fruits and vegetables and low in red meat intake have been associated with decreased risk of head and neck cancer. Additionally, chronic inflammation pathways and their association with cancer have been widely described. We hypothesized a pro-inflammatory diet, as measured by the Dietary Inflammatory Index (DII®), is associated with increased risk of head and neck cancer. Read More

    Ocular sebaceous gland carcinoma: an update of the literature.
    Int Ophthalmol 2018 Apr 25. Epub 2018 Apr 25.
    The Operation Eyesight, Universal Institute for Eye Cancer (MVC, SK), L V Prasad Eye Institute, Hyderabad, 500034, India.
    Purpose: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment.

    Methods: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. Read More

    Effectiveness of Treatment with Endostatin in Combination with Emcitabine, Carboplatin, and Gemcitabine in Patients with Advanced Non-small Cell Lung Cancer: A Retrospective Study.
    Open Med (Wars) 2018 19;13:142-147. Epub 2018 Apr 19.
    Department of Thoracic Medicine, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, P.R. China.
    This study investigated the clinical efficacy, safety and tolerance of endostatin combined with gemcitabine and carboplatin for patients with advanced nonsmall cell lung cancer (NSCLC). From January 2010 to January 2014, 49 patients with advanced NSCLC were retrospectively evaluated; we defined 2 subgroups: a combination group (chemotherapy + anti-angiogenic therapy) and a chemotherapy group (chemotherapy only). The cases in the chemotherapy group received treatment with gemcitabine and carboplatin only, whereas the cases in the combination group received endostatin in combination with gemcitabine and carboplatin. Read More

    The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case-control study.
    Int J Chron Obstruct Pulmon Dis 2018 13;13:1167-1175. Epub 2018 Apr 13.
    Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China.
    Background: COPD is considered an independent risk factor for lung cancer. COPD and lung cancer are both very heterogeneous diseases, and the study herein investigates the link between COPD phenotypes and specific histological subtypes of lung cancer.

    Methods: This case-control study comprised 2,283 patients with newly diagnosed pathological lung cancer and 2,323 non-lung cancer controls. Read More

    Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo.
    Mol Cancer Ther 2018 Apr 25. Epub 2018 Apr 25.
    China-US (Henan) Hormel Cancer Institute
    Overexpression or activation of AKT is very well known to control cell growth, survival and gene expression in solid tumors. Oridonin, an inflammatory medical and diterpenoid compound isolated from Rabdosia rubescens, has exhibited various pharmacological and physiological properties, including anti-tumor, anti-bacterial and anti-inflammatory effects. In this study, we demonstrated that oridonin is an inhibitor of AKT and suppresses proliferation of esophageal squamous cell carcinoma (ESCC) in vitro and in vivo. Read More

    Antitumor Activity of Alkylaminoguaiazulenes.
    In Vivo 2018 May-Jun;32(3):541-547
    Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan
    Background/aim: Guaiazulene (1,4-dimethyl-7-isopropylazulene) is present in several essential oils of medicinal and aromatic plants. There exist few studies that investigated the anticancer activity of guaiazulenes. We investigated the relative cytotoxicity of 10 alkylaminoguaiazulene derivatives towards both cancer and normal cells. Read More

    Anti-tumor Activity of Azulene Amide Derivatives.
    In Vivo 2018 May-Jun;32(3):479-486
    Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan
    Background/aim: There exist few research articles regarding the anticancer activity of azulene-related compounds. We investigated here the relative cytotoxicity of 10 azulene amide derivatives against cancer and normal cells.

    Materials And Methods: Cytotoxicity against four human oral squamous cell carcinoma (OSCC) cell lines and three human oral normal cells (gingival fibroblasts, periodontal ligament fibroblasts and pulp cells) was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetra-zolium bromide method. Read More

    HIF-1α and mTOR - Possible Novel Strategies of Targeted Therapies in p16-positive and -negative HNSCC.
    Cancer Genomics Proteomics 2018 May-Jun;15(3):175-184
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
    Background/aim: Targeted therapy in head and neck squamous cell carcinoma (HNSCC) is limited. HIF-1α and mTOR are involved in the formation of local tumor progression and distant metastasis. The present study analyzed the influence of well-established tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on the expression of HIF-1α and mTOR in p16-positive and -negative squamous cancer cells (SCC) in vitro in order to develop novel strategies in the treatment of HNSCC. Read More

    Common mitochondrial haplogroups and cutaneous squamous cell carcinoma risk.
    Cancer Epidemiol Biomarkers Prev 2018 Apr 25. Epub 2018 Apr 25.
    Department of Dermatology, Massachusetts General Hospital and Harvard Medical School
    Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in America, and its incidence is substantially higher in men than women, but the reasons for the difference are unknown. We explored whether common mitochondrial DNA (mtDNA) haplogroups, which have been associated with cancer risk, and in particular squamous cell carcinoma risk arising in other organs, could explain this biological sex difference in cSCC susceptibility.

    Methods: We performed a retrospective cohort study using data from the Genetic Epidemiology Research in Adult Health and Aging cohort comprised of 67,868 non-Hispanic white subjects (7,701 cSCC cases and 60,167 controls). Read More

    MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus.
    J Transl Med 2018 Apr 25;16(1):109. Epub 2018 Apr 25.
    Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.
    Background: MicroRNAs (miRNAs) play an important role in cancer biology. Neoadjuvant radiochemotherapy followed by surgery is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, a subset of patients do not respond. Read More

    The economic burden of occupational non-melanoma skin cancer due to solar radiation.
    J Occup Environ Hyg 2018 Apr 25:1-11. Epub 2018 Apr 25.
    f Occupational Cancer Research Centre , Toronto , Ontario , Canada.
    Solar ultraviolet (UV) radiation is the second most prevalent carcinogenic exposure in Canada and is similarly important in other countries with large Caucasian populations. The objective of this article was to estimate the economic burden associated with newly diagnosed non-melanoma skin cancers (NMSCs) attributable to occupational solar radiation exposure. Key cost categories considered were direct costs (healthcare costs, out-of-pocket costs (OOPCs), and informal caregiver costs); indirect costs (productivity/output costs and home production costs); and intangible costs (monetary value of the loss of health-related quality of life (HRQoL)). Read More

    Lymphoepithelioma-like carcinoma of the uterine cervix: a case report.
    Eur J Gynaecol Oncol 2017 ;38(3):459-461
    Lymphoepithelioma-like carcinoma (LELC) is a rare variant of carcinoma of the uterine cervix, of which Epstein-Barr virus (EBV) and/or human papilloma virus (HPV) may play an important role in the pathogenesis. The authors report a case of a patient with cervical LELC who was also examined for the presence of EBV and HPV. A 31-year-old Japanese female presented with irregular genital bleeding. Read More

    Mucin expression profile of benign and malignant cervical tissues and correlation with clinical-pathologic parameters.
    Eur J Gynaecol Oncol 2017 ;38(3):350-355
    Purpose: To detect the expression of mucins in diverse benign and malignant cervical tissues of cervical disease.

    Materials And Methods: 158 cases of cervical tissues were collected. Sections were stained with monoclonal antibodies against MUC1, MUC2, MIUC4, MUC5AC, and MUC20 by immunohistochemistry. Read More

    Med Pregl 2016 Oct;69(5-6):167-169
    Introduction: Thymoma is a rare malignant tumor of the anterior mediastinum. Thymic squamous cell carcinoma has been recognized as an aggressive form of thymoma with different behavior. It is associated with paraneoplastic syndromes, variety of clinical presentations, different way of treatment and complex prognosis. Read More

    Exploration of gene functions for esophageal squamous cell carcinoma using network-based guilt by association principle.
    Braz J Med Biol Res 2018 19;51(6):e6801. Epub 2018 Apr 19.
    Department of Gastroenterology (40th Ward), Daqing Oilfield General Hospital, Daqing, China.
    Gene networks have been broadly used to predict gene functions based on guilt by association (GBA) principle. Thus, in order to better understand the molecular mechanisms of esophageal squamous cell carcinoma (ESCC), our study was designed to use a network-based GBA method to identify the optimal gene functions for ESCC. To identify genomic bio-signatures for ESCC, microarray data of GSE20347 were first downloaded from a public functional genomics data repository of Gene Expression Omnibus database. Read More

    Expression of CDK6 in Oral Squamous Cell Carcinomas
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1013-1016. Epub 2018 Apr 25.
    Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Email:
    Background: CDK6 is the key factor in regulation of the cell cycle and essential for passage into the G1 phase. It also plays an important role in the development of various tumors. In this cross-sectional study expression of the CDK6 protein in oral squamous cell carcinoma (OSCC) and healthy oral mucosa of controls was assessed to determine relations with malignant transformation and clinicopathologic factors. Read More

    PAI-1, CAIX and VEGFA expressions as prognosis markers in oral squamous cell carcinoma.
    J Oral Pathol Med 2018 Apr 25. Epub 2018 Apr 25.
    Programa de Pós-Graduação em Biotecnologia - RENORBIO Universidade Federal do Espírito Santo. Vitória, ES, Brazil.
    Background: In oral squamous cell carcinoma (OSCC), the HIF-1 complex promotes the expression of genes involved in specific mechanisms of cell survival under hypoxic conditions, such as plasminogen activator inhibitor-1 (PAI-1), carbonic anhydrase 9 (CAIX) and vascular endothelial growth factor A (VEGFA). The study aimed to investigate the presence and prognostic value of PAI-1, CAIX, and VEGFA in OSCC.

    Materials And Methods: Immunohistochemistry was used to analyze the expressions of these proteins in 52 tumoral tissue samples of patients with OSCC, surgically treated and followed by a minimum of 24 months after surgery. Read More

    Serum CXCL12, but not CXCR4, Is Associated with Head and Neck Squamous Cell Carcinomas
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):901-904. Epub 2018 Apr 25.
    Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Email:
    Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region. We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, with HNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28 healthy individuals in the control group. Read More

    Comparative study of β-catenin and CD44 immunoexpression in oral lichen planus and squamous cell carcinoma.
    Int J Dermatol 2018 Apr 24. Epub 2018 Apr 24.
    Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
    Background: Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC).

    Methods: β-Catenin and CD44 expression were evaluated in 15 patients with epithelial hyperplasia (group A), 20 OLP (group B), and 20 OSCC (group C) by immunohistochemistry. Read More

    Correction to: Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
    Gen Thorac Cardiovasc Surg 2018 Apr 24. Epub 2018 Apr 24.
    Department of Gastroenterology, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
    In the original publication of the article, Fig. 1 was published incorrectly. Read More

    miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10.
    Int J Mol Med 2018 Apr 24. Epub 2018 Apr 24.
    Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China.
    Esophageal squamous cell carcinoma (ESCC) is a life‑threatening cancer with increasing incidence worldwide. MicroRNAs (miRs) have been reported to be involved in the progression of various types of cancer. In previous studies, the expression of miR‑378a‑3p was shown to be reduced in ESCC tissues. Read More

    Epithelial-Mesenchymal Transition during Metastasis of HPV-Negative Pharyngeal Squamous Cell Carcinoma.
    Biomed Res Int 2018 6;2018:7929104. Epub 2018 Mar 6.
    Department of Otorhinolaryngology, University Medical Center Göttingen, Georg-August-University Göttingen, Robert-Koch-Strasse 40, 37099 Göttingen, Germany.
    In epithelial tumors, a shift towards a mesenchymal phenotype has been associated with increased invasiveness and metastasis. It is assumed that this phenomenon plays a major role in disease progression and ultimately prognosis. This study investigated epithelial-mesenchymal transition (EMT) in human papillomavirus- (HPV-) negative pharyngeal squamous cell carcinoma. Read More

    Decreased carbonyl reductase 1 expression promotes tumor growth via epithelial mesenchymal transition in uterine cervical squamous cell carcinomas.
    Reprod Med Biol 2018 Apr 25;17(2):173-181. Epub 2018 Jan 25.
    Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan.
    Purpose: Carbonyl reductase 1 (CBR1) is involved in cancer progression. Recently, the authors reported that the loss of CBR1 expression is associated with a poor prognosis in uterine cervical cancer. Here, we investigated whether the decreased CBR1 expression promotes cancer progression by inducing the epithelial mesenchymal transition (EMT). Read More

    The association of polymorphisms in miRNAs with nonsmall cell lung cancer in a Han Chinese population.
    Cancer Manag Res 2018 10;10:697-704. Epub 2018 Apr 10.
    Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People's Republic of China.
    Background: MicroRNAs (miRNAs) have been demonstrated to play important roles in cancer progression. Recently, studies have revealed that polymorphisms in miRNAs might be associated with cancer susceptibility.

    Materials And Methods: In the current study, we investigated the associations of single nucleotide polymorphisms (SNPs) in miRNAs (rs11134527 in , rs74693964 in , rs6062251 in , and rs4705343 in ) with nonsmall cell lung cancer (NSCLC) in a Han population from Yunnan Province, Southwest China using a binary logistic regression analysis. Read More

    A neglected reddish penile patch: A wolf in sheep's clothing.
    Indian J Urol 2018 Apr-Jun;34(2):155-157
    Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Microinvasive squamous cell carcinoma (SCC) is a known premalignant lesion of carcinoma cervix. It is also reported from other sites such as the oral cavity, larynx, and vulva. Microinvasive SCC is very rarely reported from the penis. Read More

    A defect in KCa3.1 channel activity limits the ability of CD8 T cells from cancer patients to infiltrate an adenosine-rich microenvironment.
    Sci Signal 2018 Apr 24;11(527). Epub 2018 Apr 24.
    Division of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
    The limited ability of cytotoxic T cells to infiltrate solid tumors hampers immune surveillance and the efficacy of immunotherapies in cancer. Adenosine accumulates in solid tumors and inhibits tumor-specific T cells. Adenosine inhibits T cell motility through the A receptor (AR) and suppression of KCa3. Read More

    Salvage Abdominoperineal Resection for Squamous Cell Anal Cancer: A 30-Year Single-Institution Experience.
    Ann Surg Oncol 2018 Apr 24. Epub 2018 Apr 24.
    Department of Surgical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    Background: Failure of chemoradiotherapy (CRT) for anal squamous cell carcinoma (SCC) results in persistent or recurrent anal SCC. Treatment with salvage abdominoperineal resection (APR) can potentially achieve cure. The aims of this study are to analyze oncological and surgical outcomes of our 30-year experience with salvage APR for anal SCC after failed CRT and identify prognostic factors for overall survival (OS). Read More

    [Expression and correlation of HPV16E6 and tumor suppressor gene p53 in oral squamous cell carcinoma].
    Shanghai Kou Qiang Yi Xue 2017 Dec;26(6):615-618
    Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University. Nanjing 210029, Jiangsu Province, China.
    Purpose: To exploring the expression of PV16E6 gene and p53 gene in patients with oral carcinoma and the correlation between pathological grade and clinical stage of oral cancer and expression of HPV16E6 gene and p53 gene.

    Methods: One hundred and seventy-three cases of oral cancer, 98 cases of oral precancerous lesions and 79 cases of peri-cancerous normal tissue were selected. The expression of HPV16E6 and p53 was detected by immunohistochemistry. Read More

    [Expression and potential clinical significance of cytidine triphosphate: phosphocholine cytidylyltransferase-α in oral squamous cell carcinoma].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Apr;53(4):254-258
    Dental Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.
    To examine the expression and potential clinical significance of CCT (cytidine triphosphate: phosphocholine cytidylyltransferase)-α in oral squamous cell carcinoma (OSCC). Fifty-eight OSCC and paired adjacent non-malignant epithelia samples (between May 2016 and July 2016) were obtained from dental center, Second Xiangya Hospital, Central South University. CCT-α expression was examined by immunohistochemistry. Read More

    [Comparative analysis of methylation profiles in tissues of oral leukoplakia and oral squamous cell carcinoma].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Apr;53(4):248-253
    Institute of Dental Research, Capital Medical University School of Stomatology, Beijing 100050, China.
    To compare the methylation profiles in tissues of oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC) with healthy tissues of oral mucosa, in order to identify the role of DNA methylation played in tumorigenesis. DNA samples extracted from tissues of 4 healthy oral mucosa, 4 OSCC and 4 OLK collected from patients of the Department of Oral Medicine, Capital Medical University School of Stomatology were examined and compared using Methylation 450 Bead Chip. The genes associated with differentially methylated CpG sites were selected for gene ontology (GO) analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment. Read More

    Pseudomesotheliomatous Type of Sarcomatoid Squamous Cell Lung Cancer Presenting With Hemothorax.
    Ann Thorac Surg 2018 Apr 21. Epub 2018 Apr 21.
    Department of Cardiothoracic Surgery, Ahalia Hospital-Mussafah, Abudhabi, United Arab Emirates.
    A 44 year old male presented with spontaneous massive hemothorax. Computed tomography (CT) scan revealed thickened and nodular pleura with no evidence of lung tumour. Patient underwent right open total pleurectomy. Read More

    Securing the Airway in Pretracheal Dermal Metastases From Oropharyngeal Carcinoma: A Case Report.
    A A Pract 2018 Apr 23. Epub 2018 Apr 23.
    From the Departments of Anesthesiology & Perioperative Medicine.
    Dermal metastases reflect the ominous and aggressive spread of oropharyngeal squamous cell carcinomas. The rampant proliferation of these metastatic tumors to the neck results in respiratory distress and impending airway obstruction. We report a case of a patient with massive neck dermal metastases requiring urgent airway control for intermittent stridor. Read More

    A tale of two clones: caldesmon staining in the differentiation of cutaneous spindle cell neoplasms.
    J Cutan Pathol 2018 Apr 17. Epub 2018 Apr 17.
    Division of Dermatology, Washington University School of Medicine, Saint Louis, MO.
    Background: We sought to compare the sensitivity and specificity of two different caldesmon antibodies in differentiating leiomyosarcoma from other cutaneous spindle cell neoplasms.

    Methods: Representative cutaneous spindle cell neoplasms were identified, including leiomyosarcoma, atypical fibroxanthoma, dermatomyofibroma, and spindle cell squamous cell carcinoma. Immunohistochemistry was performed with antibodies directed towards caldesmon, smooth-muscle actin (SMA), and desmin. Read More

    The relationship between esophageal cancer, chagasic megaesophagus and HPV: myths, tales or reality?
    Histol Histopathol 2018 Apr 24:11993. Epub 2018 Apr 24.
    Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
    A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cell-cycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development. Read More

    Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases.
    Dermatol Ther 2018 Apr 24:e12613. Epub 2018 Apr 24.
    Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
    Actinic cheilitis (AC) can precede the development of squamous cell carcinoma (SCC) of the lip, a location with higher risk of invasiveness and metastasis. Herein, we reported the use of ingenol mebutate (IngMeb) 0.015% gel on three consecutive days to treat three patients suffering from AC. Read More

    Case of probable spontaneous regression of Merkel cell carcinoma combined with squamous cell carcinoma without surgical intervention.
    J Dermatol 2018 Apr 23. Epub 2018 Apr 23.
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
    Merkel cell carcinoma (MCC) is a rare but more lethal cutaneous cancer than melanoma. However, spontaneous regression of a number of MCC has been reported, although the cause of this regression remains unclear. In most cases, MCC regresses after a surgical procedure, for example, biopsy. Read More

    Endorsing cellular competitiveness in aberrant epithelium of oral submucous fibrosis progression: neighbourhood analysis of immunohistochemical attributes.
    Histochem Cell Biol 2018 Apr 23. Epub 2018 Apr 23.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721 302, India.
    Epithelial abnormality during the transformation of oral submucous fibrosis (OSF) into oral squamous cell carcinoma has been well studied and documented. However, the differential contribution of atrophy and hyperplasia for malignant potentiality of OSF is yet to be resolved. Existing diagnostic conjectures lack precise diagnostic attributes which may be effectively resolved by substantiation of specific molecular pathology signatures. Read More

    Asymptomatic pancreatic body herniation complicated with periauricular squamous cell carcinoma.
    Eur J Radiol Open 2018 13;5:64-66. Epub 2018 Apr 13.
    Acibadem University- Atakent Hospital, Department Of Radiology, Turgut Ozal Street No:16, 34303, Kucukcekmece, Istanbul, Turkey.
    Hiatus hernia is defined as herniation of the abdominal elements through the esophageal hiatus into the madiastinum. Type IV hiatal herniation is the rarest of all paraoesaphagial hernias. Herniation of pancreas is extremely rare. Read More

    Grinspan's Syndrome: A Rare Case with Malignant Transformation.
    Case Rep Otolaryngol 2018 4;2018:9427650. Epub 2018 Mar 4.
    Department of Otolaryngology, Istanbul Medeniyet University Medical Faculty, Goztepe Training and Research Hospital, Istanbul, Turkey.
    Aim: Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan's syndrome in 1966. Read More

    Intraoral Potentially Malignant Disorders in a Brazilian Oral Pathology Service: Epidemiological, Clinical, and Histopathological Findings.
    J Oncol 2018 1;2018:2325808. Epub 2018 Mar 1.
    Department of Pathology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
    The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD) in an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia (ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports. Read More

    Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife.
    World J Gastroenterol 2018 Apr;24(15):1632-1640
    Department of Gastroenterology, DGH, SGU, WI, Birmingham City University, Birmingham B4 7BD, United Kingdom.
    Aim: To determine short- and long-term outcomes of endoscopic submucosal dissection (ESD) using the stag beetle (SB) knife, a scissor-shaped device.

    Methods: Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Read More

    Tonsillar Small Cell Carcinoma: Potential Contribution of Human Papillomavirus.
    Am J Case Rep 2018 Apr 24;19:482-485. Epub 2018 Apr 24.
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
    BACKGROUND Extrapulmonary small cell carcinoma (SmCC) is a relatively rare clinical entity constituting only 2.5-5% of SmCCs. Recently, evidence has emerged that high-risk types of human papillomavirus (HPV) might play an etiologic role in oropharyngeal SmCC, similar to squamous cell carcinoma. Read More

    Pearls & Oy-sters: The critical role of histopathology in diagnosing cancer-associated necrotizing CNS vasculitis.
    Neurology 2018 Apr;90(17):808-811
    From Wake Forest University School of Medicine (J.S.); and the Departments of Neurology (J.T., R.E.S., A.G.), Pathology (R.M.), Radiology (C.G.), and Rheumatology (R.W.), Wake Forest Baptist Medical Center, Winston-Salem, NC.
    Objective: To highlight the importance of a broad differential and histopathologic confirmation in patients with newly diagnosed cancer with brain lesions atypical for CNS metastasis.

    Methods: We report 2 cases of biopsy-proven CNS vasculitis in patients undergoing treatment for a newly diagnosed nonmetastatic cancer. Comprehensive medical record review was performed to identify the clinical presentation, representative neuroimaging, histopathologic features, and response to treatment. Read More

    Oral Lichen planus.
    J Biol Regul Homeost Agents 2018 Mar-Apr;32(2):391-395
    Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
    Oral Lichen planus (OLP) is the most frequent mucosal localization of Lichen planus, affecting about 1-2% of the population. It is associated with skin lesions in 60-70% of cases, while occurring as the only manifestations in 15-25% of patients. Six clinical forms of OLP are identified: reticular (the most common), plaque, papular, atrophic, vesicles/bullous and erosive. Read More

    [A Case of Sarcomatoid Squamous Cell Carcinoma of the Penis].
    Hinyokika Kiyo 2018 Feb;64(2):79-82
    The Department of Urology, Asahikawa Red Cross Hospital.
    A 74-year-old man presented to our hospital with the swelling of penis in May 2016. Physical examination revealed a goose egg-sized lump at the tip of the penis under foreskin. After dorsal skin incision we confirmed the 7 cm tumor on the inner preputial skin and then resected the tumor with circumcision. Read More

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