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    Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma.
    Oncotarget 2017 Jun 12. Epub 2017 Jun 12.
    Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    This study evaluated the predictive value of the preoperative albumin/globulin ratio (AGR) in laryngeal squamous cell carcinoma (LSCC) retrospectively, which has not been reported before. The current study enrolled 241 newly diagnosed LSCC patients in the Second Affiliated Hospital of Nanchang University between January 2005 and December 2010. The optimal AGR cut-off value for overall survival (OS) was determined to be 1. Read More

    Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: A systematic review.
    Eur J Cancer 2017 Jun 24;82:115-127. Epub 2017 Jun 24.
    Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center/Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands. Electronic address:
    Head and neck squamous cell carcinoma (HNSCC) is typically regarded as a disease of elderly people. However, increasing numbers of patients worldwide with HNSCC at younger age (defined as <45 years old) have been reported in recent years. To assess geographical variations and trends worldwide in incidence of oral and oropharyngeal cancer in young patients, a systematic review was conducted in PubMed and Google scholar databases from 1975 to June 2016. Read More

    Generation and characterization of a human oral squamous carcinoma cell line SCC-9 with CRISPR/Cas9-mediated deletion of the p75 neurotrophin receptor.
    Arch Oral Biol 2017 Jun 24;82:223-232. Epub 2017 Jun 24.
    Department of Oral and Maxillofacial Surgery, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Shandong University, Jinan, Shandong 250012, PR China. Electronic address:
    Objective: To investigate the importance of the p75 neurotrophin receptor (p75(NTR)) in human tongue squamous carcinoma cells, we exploited the CRISPR/Cas9 technology to establish a p75(NTR)-knockout SCC-9 cell line and to explore the effect on biological functions.

    Materials And Methods: The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated endonuclease (Cas9) system was used to generate genomic deletion mutants of p75(NTR) in the tongue squamous carcinoma cell lines SCC-9. Single-guide RNA (sgRNA) sequences were designed to target the p75(NTR) genomic sequence and were cloned into plasmid pGK1. Read More

    Detection of High-Risk Histologic Features and Tumor Upstaging of Nonmelanoma Skin Cancers on Debulk Analysis: A Quantitative Systematic Review.
    Dermatol Surg 2017 Jun 23. Epub 2017 Jun 23.
    *Department of Dermatology, Boston University Medical Center, Boston, Massachusetts; †Department of Economics, Arizona State University, Tempe, Arizona; ‡Department of Dermatology, VA Boston Healthcare System, Jamaica Plains Campus, Boston, Massachusetts; §Department of Dermatology, Tufts Medical Center, Boston, Massachusetts.
    Background: Histologic analysis of tumor debulks from Mohs micrographic surgery (MMS) or wide local excision may lead to the detection of adverse features missed on initial biopsy.

    Objective: Determine the incidence of (1) high-risk features on debulk analysis compared with initial biopsy and (2) upstaging of tumors on debulk analysis according to the American Joint Committee of Cancer-7th Edition (AJCC-7) and the Brigham and Women's Alternative (BWH) staging criteria.

    Materials And Methods: A comprehensive search strategy using PubMed/MEDLINE, Web of Science, and EMBASE was conducted to identify articles published from 1960 to present that detail histology of initial biopsy and debulked tumor. Read More

    Long-Lived Epidermal Cancer-Initiating Cells.
    Int J Mol Sci 2017 Jun 27;18(7). Epub 2017 Jun 27.
    Department of Medicine, Monash University Central Clinical School, Prahran, VIC 3004, Australia.
    Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population, as well as an economic load to the health care system; yet treatments of these preventable cancers remain ineffective. Studies estimate that there has been a 2-fold increase in the incidence of NMSCs between the 1960s and 1980s. The increase in cases of NMSCs, as well as the lack of effective treatments, makes the need for novel therapeutic approaches all the more necessary. Read More

    HIF-2α not HIF-1α overexpression confers poor prognosis in non-small cell lung cancer.
    Tumour Biol 2017 Jun;39(6):1010428317709637
    1 Division of Thoracic Surgery, Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China.
    HIF-α may play an important role in the process of tumorigenesis as well as tumor progression. Although a number of investigations have established the significance of HIF-1α in several human tumors, there is still little information available on the clinical significance of HIF-2α expression in non-small cell lung cancer (NSCLC). In present study, immunohistologic expression of HIF-1α/ HIF-2α was studied in a tissue microarray of 140 Stage I-III NSCLCs and correlated with clinicopathologic parameters and clinical outcome. Read More

    DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients.
    Tumour Biol 2017 Jun;39(6):1010428317714625
    1 Department of Clinical Laboratory, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
    DJ-1 is a novel oncogene that can transform NIH3T3 cells in cooperation with the activated ras gene. DJ-1 appears to have its greatest effect on tumourigenesis, and it may have a greater impact on early-stage lung cancers. In this study, we proposed to investigate the clinical value of DJ-1 protein in the early diagnosis of lung cancer and compared its diagnostic value with other biomarkers. Read More

    Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
    Tumour Biol 2017 Jun;39(6):1010428317708532
    1 Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
    Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1α and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression. However, its expression has recently been reported to be highly elevated in a series of tumors, including prostate cancer, breast cancer, and non-small cell lung cancer, indicating that sirtuin 6 plays dual roles in tumorigenicity in a cell/tumor type-specific manner. To our knowledge, the biological roles of sirtuin 6 in esophageal cancer cells have still been underestimated. Read More

    Massive tumor embolism in the abdominal aorta from pulmonary squamous cell carcinoma: Case report and review of the literature.
    Pathol Int 2017 Jun 27. Epub 2017 Jun 27.
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan.
    Acute arterial tumor embolism is a rare complication in cancer patients. Most of the previously reported cases of arterial tumor embolism have been associated with pulmonary malignancies and occurred during the intraoperative and postoperative periods. Very few cases occurred spontaneously. Read More

    MicroRNA-539 Inhibits the Epithelial-Mesenchymal Transition of Esophageal Cancer Cells By Twist-Related Protein 1-Mediated Modulation of Melanoma Associated Antigen A4 (MAGEA4).
    Oncol Res 2017 Jun 12. Epub 2017 Jun 12.
    Department of Thoracic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
    MicroRNAs (miR) play key roles in cancers, yet the potential molecular mechanisms of miR-539 on esophageal squamous cell carcinoma (ESCC) are not well understood. Screened by informatics method, Twist-related protein 1 (TWIST1) was hypothesized to be a possible target gene of miR-539. Since the melanoma associated antigen (MAGE) A4 is reported to be up-regulated by TWIST1, this study aimed to examine the biological functions and mechanism involving TWIST1 and MAGE4 of miR-539 in ESCC. Read More

    An amazing cause of false pet positivity: Diagnosed after a lung cancer surgery.
    Diagn Cytopathol 2017 Jun 26. Epub 2017 Jun 26.
    Department of Pathology, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
    Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has an effective role in both diagnosis and management of patients with lung cancer. There are many reasons could cause false positivity on PET/CT.A 60-year-old man was admitted a mass on thorax CT and diagnosed as squamous cell carcinoma. Read More

    Angiotensin 1-7 inhibits angiotensin II-stimulated head and neck cancer progression.
    Eur J Oral Sci 2017 Jun 27. Epub 2017 Jun 27.
    Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
    Angiotensin II (Ang II) is the product of the proteolytic action of angiotensin-converting enzyme (ACE) on the precursor peptide, angiotensin I (Ang I). In addition to its vasoactive properties, Ang II is able to stimulate angiogenesis and act as a mitogen, promoting cellular proliferation. Recently, evidence has emerged that Ang II is also able to promote tumour invasion, a key step in the metastatic cascade, although the mechanisms by which it does so remain largely obscure. Read More

    Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report.
    Cell Oncol (Dordr) 2017 Jun 26. Epub 2017 Jun 26.
    Department of Clinical Medicine, Clinicum, University of Helsinki, Helsinki, Finland.
    Purpose: Recent reports indicate that histamine and its novel, high-affinity histamine H4 receptor (H4R) play a role in carcinogenesis, and thus H4R signalling has become a focus of increasing interest in the pathogenesis of many cancers. The roles of H4R in oral epithelial dysplasia (OED) and oral tongue squamous cell carcinoma (OTSCC) are unknown. The purpose of this study was to assess H4R expression in OTSCC patients and in OTSCC-derived cell lines. Read More

    Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
    J Cancer Res Clin Oncol 2017 Jun 26. Epub 2017 Jun 26.
    Department of Otolaryngology, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    Purpose: Intracellular antioxidant enzymes are commonly upregulated in various cancer types and are associated with treatment outcomes. Because the relationship has rarely been examined in oral squamous cell carcinoma (OSCC), we aimed to evaluate the association between the levels of glutathione peroxidase (GPX)1, GPX4, and thioredoxin reductase (TrxR)1 expression and prognosis in patients with OSCC who underwent curative surgical resection.

    Methods: This study included 233 patients who underwent curative surgery for previously untreated OSCC between 2000 and 2012. Read More

    Accelerated or hyperfractionated radiotherapy for esophageal carcinoma: a meta-analysis of randomized controlled trials.
    Onco Targets Ther 2017 13;10:2971-2981. Epub 2017 Jun 13.
    Department of Radiotherapy, Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
    Objective: The goal of this study was to evaluate the efficacy and safety of modified (accelerated and/or hyperfractionated) radiotherapy in the treatment of esophageal carcinoma, compared with conventional radiotherapy.

    Methods: Studies published in the PubMed, Cochrane Library, EMBASE, CBM, VIP, CNKI and Wanfang databases in the most recent two decades were searched for use in this meta-analysis. Only randomized controlled trials were included. Read More

    Vasculogenic mimicry is associated with increased tumor-infiltrating neutrophil and poor outcome in esophageal squamous cell carcinoma.
    Onco Targets Ther 2017 9;10:2923-2930. Epub 2017 Jun 9.
    Department of Radiation Oncology, Qianfoshan Hospital Affiliated to Shandong University.
    Purpose: Vasculogenic mimicry (VM) is known to be a mechanism to nourish the tumor, but little is known about its prognostic significance in esophageal squamous cell carcinoma (ESCC). We characterized the predictive relevance of VM expression and tumor-infiltrating neutrophil (TIN) density in patients with resectable ESCC.

    Methods: We retrospectively collected clinicopathologic characteristics of 117 esophageal cancer (EC) patients undergoing complete resection and without preoperative therapy. Read More

    Role of matrix metalloproteinase-9 in transforming growth factor-β1-induced epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
    Onco Targets Ther 2017 2;10:2837-2847. Epub 2017 Jun 2.
    Department of Pathology, Basic Medical College of Zhengzhou University.
    Epithelial-mesenchymal transition (EMT) is thought to be a crucial event during the early metastasis of tumor cells. Transforming growth factor (TGF)-β1 is involved in the process of EMT in a variety of human malignancies. Matrix metalloproteinase (MMP)-9 plays an important role in tumor invasion and metastasis, and its expression is regulated by various growth factors, including TGF-β1, in different cell types. Read More

    GLI1 blockade potentiates the antitumor activity of PI3K antagonists in lung squamous cell carcinoma.
    Cancer Res 2017 Jun 26. Epub 2017 Jun 26.
    Department of Internal Medicine, University of Texas Southwestern
    Lung squamous cell carcinoma (SCC), strongly associated with smoking, is treated primarily with traditional cytotoxic chemotherapy due to a lack of FDA-approved targeted agents available. Here we identify the Hedgehog pathway transcription factor GLI1 as a critical driver of lung SCC. Analysis of human lung cancer datasets showed that GLI1 mRNA was highly expressed in human lung SCC and portended a poor prognosis. Read More

    Nivolumab versus standard, single-agent therapy of investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141): health-related quality-of-life results from a randomised, phase 3 trial.
    Lancet Oncol 2017 Jun 23. Epub 2017 Jun 23.
    Centre Antoine Lacassagne, FHU OncoAge, Université Côte d'Azur, Nice, France.
    Background: Patients with platinum-refractory recurrent or metastatic squamous cell carcinoma of the head and neck have few treatment options and poor prognosis. Nivolumab significantly improved survival of this patient population when compared with standard single-agent therapy of investigator's choice in Checkmate 141; here we report the effect of nivolumab on patient-reported outcomes (PROs).

    Methods: CheckMate 141 was a randomised, open-label, phase 3 trial in patients with recurrent or metastatic squamous cell carcinoma of the head and neck who progressed within 6 months after platinum-based chemotherapy. Read More

    SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers.
    Tumour Biol 2017 Jun;39(6):1010428317711406
    1 Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.
    Long non-coding RNAs are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that long non-coding RNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. Among numerous long non-coding RNAs, we focus on Sprouty4-Intron 1 (SPRY4-IT1), a well-known long non-coding RNA that is overexpressed in various kinds of tumor tissues and cell lines. Read More

    Manifestation of osteoblastic phenotypes in the sarcomatous component of epithelial carcinoma and sarcomatoid carcinoma.
    Tumour Biol 2017 Jun;39(6):1010428317704365
    1 Department of Pathology, Faculty of Medicine, Kindai University, Osaka, Japan.
    Epithelial carcinomas occasionally have sarcomatous components that consist primarily of spindle and cuboidal cells, which often resemble osteoblasts. Sarcomatoid carcinomas consist of similar cells. Recent studies have characterized these phenomena as a manifestation of epithelial-mesenchymal transition in carcinoma cells, but the mesenchymal phenotypes that manifest in sarcomatous cells of epithelial carcinomas are not well understood. Read More

    Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal squamous cell carcinoma.
    Tumour Biol 2017 Jun;39(6):1010428317705013
    1 Department of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
    PTOV1 has been demonstrated to play an extensive role in many types of cancers. This study takes the first step to clarify the potential relationship between esophageal squamous cell carcinoma and PTOV1 expression and highlight the link between PTOV1 and the tumorigenesis, progression, and prognosis of esophageal squamous cell carcinoma. PTOV1 expression was detected by quantitative reverse transcription polymerase chain reaction and western blotting or immunohistochemical staining in esophageal squamous cell carcinoma cell lines, esophageal squamous cell carcinoma tissues, and its paired adjacent non-cancerous tissues. Read More

    Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: A subset analysis of EORTC 24971 study.
    Ann Oncol 2017 Jun 23. Epub 2017 Jun 23.
    Medical Oncology, Antwerp University Hospital, Edegem, Belgium.
    Background: EORTC 24971 was a phase III trial demonstrating superiority of induction regimen TPF over PF, in terms of progression-free (PFS) and overall survival (OS) in locoregionally advanced unresectable HNSCC. We conducted a retrospective analysis of prospectively collected data aiming to evaluate whether only HPV(-) patients (pts) benefit from adding docetaxel to PF, in which case de-intensifying induction treatment in HPV(+) pts could be considered.

    Methods: Pre-therapy tumor biopsies (blocks or slides) were assessed for high-risk HPV by p16 immunohistochemistry, PCR and qPCR. Read More

    Fluorescent Nanoparticle Imaging Allows Noninvasive Evaluation of Immune Cell Modulation in Esophageal Dysplasia.
    Mol Imaging 2014 May;13(3):7290201400003
    From the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA; Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; and Division of Digestive and Liver Diseases, Department of Medicine, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY.
    Esophageal tumors provide unique challenges and opportunities for developing and testing surveillance imaging technology for different tumor microenvironment components, including assessment of immune cell modulation, with the ultimate goal of promoting early detection and response evaluation. In this context, accessibility through the lumen using a minimally invasive approach provides a means for repetitive evaluation longitudinally by combining fluorescent endoscopic imaging technology with novel fluorescent nanoparticles that are phagocytized by immune cells in the microenvironment. The agent we developed for imaging is synthesized from Feraheme (ferumoxytol), a Food and Drug Administration-approved monocrystaline dextran-coated iron oxide nanoparticle, which we conjugated to a near-infrared fluorochrome, CyAL5. Read More

    Uncovering the role of brain-derived neurotrophic factor (BDNF)/TrkB signaling in head and neck malignancies.
    J Oral Pathol Med 2017 Jun 26. Epub 2017 Jun 26.
    Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
    Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that was first known as responsible for sustain the growth, function and plasticity of neural cells. BDNF exerts its effects by binding to the tyrosine kinase receptor B (TrkB). The BDNF/TrkB axis has been reported to be overexpressed in several neurogenic and non-neurogenic tumors. Read More

    IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.
    J Clin Invest 2017 Jun 26. Epub 2017 Jun 26.
    Merck & Co. Inc., Kenilworth, New Jersey, USA.
    Programmed death-1-directed (PD-1-directed) immune checkpoint blockade results in durable antitumor activity in many advanced malignancies. Recent studies suggest that IFN-γ is a critical driver of programmed death ligand-1 (PD-L1) expression in cancer and host cells, and baseline intratumoral T cell infiltration may improve response likelihood to anti-PD-1 therapies, including pembrolizumab. However, whether quantifying T cell-inflamed microenvironment is a useful pan-tumor determinant of PD-1-directed therapy response has not been rigorously evaluated. Read More

    Distant metastases in head and neck cancer.
    Head Neck 2017 Jun 26. Epub 2017 Jun 26.
    Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
    Background: Most trials in head and neck cancer emphasize locoregional control, as this is the main pattern of therapy failure. However, up to 15% of patients develop distant metastases. The purpose of this study was to present the investigated factors associated with distant metastasis in a single-center patient cohort. Read More

    Circulating HMGA2 and PLAG1 in blood of patients with oral squamous cell carcinoma.
    J Oral Pathol Med 2017 Jun 26. Epub 2017 Jun 26.
    Department of Oral Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China.
    Background: High mobility group AT-hook 2 (HMGA2) and pleomorphic adenoma gene 1(PLAG1) have been demonstrated to be elevated in many malignant tumors. However, the aim of this study was to evaluate HMGA2 and PLAG1 levels in blood as a non-invasive biomarker for oral squamous cell carcinoma (OSCC) diagnosis.

    Methods: qRT-PCR was performed to measure circulating HMGA2 and PLAG1 levels in OSCC patients (n=43) and matched cancer-free blood control group (n=21). Read More

    Evaluation of cortical mandibular bone in patients with oral squamous cell carcinoma.
    Clin Oral Investig 2017 Jun 24. Epub 2017 Jun 24.
    Stomatology Department, A.C.Camargo Cancer Center, Professor Antônio Prudente St 211, São Paulo, SP, 01509-900, Brazil.
    Objectives: The aim of the study was to evaluate the mandible cortical bone changes in patients with oral squamous cell carcinoma (OSCC).

    Patients And Methods: Twenty patients who underwent some mandibular bone removal as part of the treatment of OSCC had bone samples collected in two parts: in the proximity of the tumor (BPT) and in the surgical margin (BEP). Cortical microarchitecture was analyzed trough micro-computed tomography, together with texture analysis, followed by microcrack evaluation in histological sections and gene expression of RANK, RANKL, OPG, and sclerostin by quantitative polymerase chain reaction. Read More

    Comparative miRNA Expression Profile Analysis of Squamous Cell Carcinoma and Peritumoral Mucosa from the Meso- and Hypopharynx.
    Cancer Genomics Proteomics 2017 Jul-Aug;14(4):285-292
    PTE KK Department of Otorhinolaryngology and Head and Neck Surgery, Pécs, Hungary.
    Background/aim: The role of microRNAs (miRNA) in carcinogenesis is related to their genome-regulatory function. The aim of the present study was to identify and compare miRNA expression signatures of meso- and hypopharynx squamous cell cancers in consideration of the cancer field hypothesis.

    Patients And Methods: Thirteen snap-frozen biopsy series of tumors and peritumoral tissues from the meso- and hypopharynx were analyzed regarding their miRNA expression with quantitative real-time polymerase chain reaction (qRT-PCR). Read More

    Human papillomavirus infection increases the chemoradiation response of esophageal squamous cell carcinoma based on P53 mutation.
    Radiother Oncol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, PR China. Electronic address:
    Background And Purpose: A retrospective study was carried out to analyze multiple prognostic predictors, including human papillomavirus (HPV) infection for chemoradiation treatment of esophageal squamous cell carcinoma (ESCC).

    Materials And Methods: DNA extracted from a total of 192 patients treated with chemoradiation for locally advanced ESCC was examined to determine HPV status by polymerase chain reaction (PCR) and P53 gene mutation by genetic sequencing. The relationships between the chemoradiation response (CRR) and overall survival (OS) rate with HPV status and P53 gene mutation were analyzed. Read More

    Risk factors for lymph node metastases of facial cutaneous squamous cell carcinoma.
    J Craniomaxillofac Surg 2017 May 22. Epub 2017 May 22.
    Department of Oral & Maxillofacial Surgery (Head: Prof. Dr. Dr. M. Ehrenfeld), University of Munich, LMU, Germany. Electronic address:
    Purpose: Determining the risk factors for lymph node metastases of facial cutaneous squamous cell carcinoma and identifying their value for predicting nodal spread.

    Material And Methods: Data on 99 patients were examined retrospectively. Conditions such as tumor staging, tumor thickness, location, histological grading, R1-resection, local recurrence, lymph node metastases, and neurovascular and lymphovascular invasion were evaluated. Read More

    Comorbidity Assessment in Patients With Oral Squamous Cell Carcinoma: Can Imaging Techniques (Fludeoxyglucose Positron-Emission Tomographic Computed Tomography and Contrast-Enhanced Computed tomography) Provide Additional Information?
    J Oral Maxillofac Surg 2017 May 31. Epub 2017 May 31.
    Associate Professor, Department of Oral and Maxillofacial Surgery, Ludwig Maximilians University of Munich, Munich, Germany.
    Purpose: This study evaluated the role of imaging staging examinations (positron-emission tomographic computed tomography [PET/CT] and contrast-enhanced computed tomography [ceCT]) for the assessment of the comorbidity status of patients with oral squamous cell carcinoma (OSCC). A binary null hypothesis was drafted: 1) imaging staging examinations do not augment knowledge about the comorbidity status of patients with OSCC and 2) there is no difference between PET/CT and ceCT in this regard.

    Materials And Methods: A retrospective cohort study design was selected to address the research question. Read More

    Vismodegib for Recurrent Locally Destructive Basal Cell Carcinoma in a Renal Transplant Patient.
    J Eur Acad Dermatol Venereol 2017 Jun 24. Epub 2017 Jun 24.
    Department of Dermatology, Paracelsus Medical University, Salzburg, Austria.
    Solid organ transplant patients are at an increased risk of developing cutaneous malignancies owing to long-lasting immunosuppression. The strongest increase in incidence (35-fold) has been reported for cutaneous squamous cell carcinoma [1]. Basal cell carcinoma (BCC) may occur even more frequently, especially during the first years after transplantation [2]. Read More

    Genetic variants in microRNA-binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx.
    Int J Cancer 2017 Jun 24. Epub 2017 Jun 24.
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    The incidence of squamous cell carcinoma of the oropharynx (SCCOP) continues to rise because of increasing rates of human papillomavirus (HPV) infection. Inherited polymorphisms in DNA repair pathways may influence the risk of SCCOP development and the prognosis of SCCOP. We sought to determine whether polymorphisms in microRNA (miRNA)-binding sites within 3'-untranslated regions (3'UTRs) of genes in DNA repair pathways modulate the risk of SCCOP recurrence. Read More

    Sinonasal malignancies: incidence and histological distribution in Jamaica, 1973-2007.
    Cancer Causes Control 2017 Jun 23. Epub 2017 Jun 23.
    Jamaica Cancer Registry, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica.
    Purpose: To determine the histological distribution and trends in incidence of sinonasal malignancies in Jamaica.

    Methods: Cases of all sinonasal malignancies diagnosed between 1973 and 2007 were extracted from the archives of the Jamaica Cancer Registry. Data recorded for each case included age at diagnosis, sex, year of diagnosis, topography, and histology. Read More

    Extent of Mediastinal Lymphadenectomy and Survival in Superficial Esophageal Squamous Cell Carcinoma.
    J Gastrointest Surg 2017 Jun 23. Epub 2017 Jun 23.
    Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
    Background: The aim of this study is to investigate the utility of total mediastinal lymphadenectomy (ML) in superficial esophageal squamous cell carcinoma (ESCC).

    Methods: The medical records of 129 patients who underwent esophagectomy and lymph node dissection for pathologically confirmed pT1 ESCC between July 2006 and December 2014 were retrospectively reviewed. Limited ML, such as traditional 2-field or transhiatal esophagectomy, was performed in 42 patients (group 1), and total ML, including the bilateral recurrent laryngeal nerve nodes, was performed in 87 patients (group 2). Read More

    A potential role of the unfolded protein response in post-transplant cancer.
    Clin Sci (Lond) 2017 Jul 22;131(13):1429-1436. Epub 2017 Jun 22.
    Service de Biochimie, Centre de Biologie Humaine (CBH), CHU Amiens Sud, Amiens, France
    Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically associated with skin cancers (both squamous cell carcinoma and melanoma) and renal cell carcinoma (RCC). Recent studies have shown that in addition to its immunosuppressive effects, accounted for by the inhibition of calcineurin and the modulation of the transcriptional programme of lymphocytes, CsA also directly stimulates the growth and aggressive behaviour of various cancer cells. Read More

    Prognostic implication of ERCC1 protein expression in resected oropharynx and oral cavity cancer.
    Pathol Res Pract 2017 May 31. Epub 2017 May 31.
    Division of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
    Background: Excision repair cross complement group 1 (ERCC1) expression is a predictive biomarker for platinum-containing treatment in squamous cell carcinoma of head and neck (SCCHN). However, the prognostic significance after surgical resection is not well understood.

    Methods: Oropharynx (n=143) or oral cavity (n=61) SCCHN patients undergoing surgery were included. Read More

    High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation.
    J Exp Clin Cancer Res 2017 Jun 23;36(1):84. Epub 2017 Jun 23.
    Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
    Background: Oesophageal cancer is one of the most common malignancies worldwide,and oesophageal squamous cell carcinoma (ESCC) is the predominant histological type both globally and in China. Collagen triple helix repeat containing 1 (CTHRC1) has been found to be upregulated in ESCC. However, its role in tumourigenesis and progression of ESCC remains unclear. Read More

    Alcohol Metabolism and Oesophageal Cancer: A Systematic Review of the Evidence.
    Carcinogenesis 2017 Jun 22. Epub 2017 Jun 22.
    International Agency for Research on Cancer (IARC-WHO), Lyon, France.
    Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review of current epidemiological evidence of the relationship between alcohol intake and OC risk, including the role of tobacco smoking and functional polymorphisms of dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs). Read More

    A three gene immunohistochemical panel serves as an adjunct to clinical staging of patients with head and neck cancer.
    Oncotarget 2017 Jun 19. Epub 2017 Jun 19.
    Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, S169857, Singapore.
    Background: Current management of head and neck squamous cell carcinoma (HNSCC) depends on tumor staging. Despite refinements in clinical staging algorithms, outcomes remain unchanged for the last two decades. In this study, we set out to identify a small, clinically applicable molecular panel to aid prognostication of patients with HNSCC. Read More

    Expression of p63 and CD44 in oral squamous cell carcinoma and correlation with clinicopathological parameters.
    Arch Oral Biol 2017 Jun 15;82:160-165. Epub 2017 Jun 15.
    Biostatistical Sciences Department, Mashhad University of Medical Sciences, Mashhad, Iran.
    Squamous cell carcinoma (SCC) is the sixth most frequent malignant tumor of the head and neck region. Despite advances in therapeutic options over the last decades, the rate of mortality and morbidity has not been improved markedly. A small subset of cells, cancer stem cells (CSCs), with self-renewal properties have become a major focus of current cancer research. Read More

    Current understanding of cancer stem cells: Review of their radiobiology and role in head and neck cancers.
    Head Neck 2017 Jun 23. Epub 2017 Jun 23.
    International Centre for Allied Health Evidence and Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
    Evidence of cancer cells that bear attributes analogous to those of normal stem cells has developed a hierarchical model of cancer's architecture and progression. This subset of cancer stem cells (CSCs) drives the progression and therapy resistance of cancers. Research to identify the phenotypes of these CSCs presents evidence of a subpopulation that is more resistant to therapy and may proliferate in response. Read More

    Cytokeratin 19 expression in early oral squamous cell carcinoma and their metastasis: Inadequate biomarker for one-step nucleic acid amplification implementation in sentinel lymph node biopsy procedure.
    Head Neck 2017 Jun 23. Epub 2017 Jun 23.
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step nucleic acid amplification rapidly detects cytokeratin 19 (CK19) RNA with high accuracy. Sensitivity and specificity of CK19 expression in OSCC was evaluated. Read More

    Effect of TET1 regulating MGMT on chemotherapy resistance of oral squamous cell carcinoma stem cells.
    J Cell Biochem 2017 Jun 23. Epub 2017 Jun 23.
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
    The study was to evaluate the effect of ten-eleven translocation 1 (TET1) regulating o6-methylguanine-DNA methyltransferase (MGMT) in chemotherapy resistance of oral squamous cell carcinoma (OSCC) stem cells. OSCC stem cells were divided into the blank, negative control (NC), TET1-siRNA, TET1-siRNA + MGMT-OE and MGMT-OE groups. Methylation-specific polymerase chain reaction (MSP), qRT-PCR and western blotting were conducted to detect the methylation status of MGMT, expressions of TET1, MGMT, ABCG2 and Oct-4. Read More

    Bowen's disease: Two case reports of a giant and dwarf lesions.
    J Cancer Res Ther 2017 Apr-Jun;13(2):371-373
    Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.
    Bowen's disease is a form of intraepidermal squamous cell carcinoma (SCC). It usually presents as a well-demarcated, slow growing erythematous patch, or plaque with a scaly or crusted surface. The size of the tumor varies from a few millimeters to several centimeters. Read More

    The significance of serum leptin level in patients with early stage nonsmall cell lung cancer.
    J Cancer Res Ther 2017 Apr-Jun;13(2):204-207
    Department of Medical Oncology, Faculty of Medicine, Ankara University, Ankara, Turkey.
    Backgrounds: The serum leptin level (SLL) has been shown to increase in patients with nonsmall cell lung cancer (NSCLC). However, available data regarding the relation between SLL and tumor subtypes, survival, cachexia, and tumor respectability in NSCLC are still under debate. The aim of this study is to evaluate SLL in NSCLC patients with and without cachexia. Read More

    [Progress of the application of optical coherence tomography in gastrointestinal tumor surgery].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Jun;20(6):716-720
    Department of General Surgery Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    Optical coherence tomography (OCT) is a real-time, cross-sectional optical imaging technology. It is analogous to ultrasonography, except that OCT uses light waves instead of sound waves, and can provide three-dimensional morphological images of living tissues with a micrometer resolution. Through the use of endoscopes, needles, catheters and laparoscopes, OCT has demonstrated tremendous imaging potential in tumor surgery. Read More

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