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Esophagus 2018 Dec 13. Epub 2018 Dec 13.

AI Medical Service Inc., Tokyo, Japan.

Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More

Cancer Chemother Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Respiratory and Critical Care, The First Affiliated Hospital of Soochow University, No.899, Pinghai Road, Suzhou, 215006, People's Republic of China.

Purpose: Platinum-based doublet chemotherapy and radiotherapy are the standard treatment option in advanced squamous cell carcinoma patients. However, few agents could be selected for subsequent post-second-line treatment. As a small molecule inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, apatinib had been proved in advanced gastric cancer. Read More

Acta Derm Venereol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Epidemiology and Applied Biostatistics, University Hospital Tübingen, DE-72076 Tübingen, Germany.

Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Read More

JAAD Case Rep 2019 Jan 4;5(1):7-11. Epub 2018 Dec 4.

Department of Dermatology, Oregon Health and Sciences University, Portland, Oregon.

Oncoimmunology 2019 21;8(1):e1515057. Epub 2018 Sep 21.

Cancer Research Institute, Seoul National University, Seoul, Korea.

Major histocompatibility complex (MHC) class I downregulation is the primary immune evasion mechanism associated with failure in anti-PD-1/PD-L1 blockade therapies for cancer. Here, we examined the role of MEK signaling pathway inhibition in head and neck squamous cell carcinoma (HNSCC) both and . We found that trametinib, a small molecule inhibitor of MEK, significantly enhanced MHC class I and PD-L1 expression in human HNSCC cell lines, and this occurred via STAT3 activation. Read More

Mol Clin Oncol 2018 Dec 5;9(6):666-672. Epub 2018 Oct 5.

Oncology Research Group, Santa Terezinha University Hospital, Joaçaba, SC 89600-000, Brazil.

Although the mortality rate of oropharyngeal squamous cell carcinoma (OPSCC) has been decreasing over the last 30 years, there has been a significant increase in the frequency of diagnosis of this type of cancer in several countries. Beyond the classic prognostic factors, such as TNM stage, there is a lack of predictive factors for recurrence and treatment response. A retrospective analysis of patients with OPSCC treated at the Oncology Department of the Santa Terezinha University Hospital between 2007 and 2012 was performed, with the aim of identifying new prognostic factors. Read More

Mol Clin Oncol 2018 Dec 25;9(6):640-646. Epub 2018 Sep 25.

Division of Chest Surgery, Department of Surgery, Showa University School of Medicine, Tokyo 142-8666, Japan.

The expression levels of thymidine phosphorylase (), dihydropyrimidine dehydrogenase (), thymidylate synthase () and orotate phosphoribosyltransferase () may predict the clinical efficacy of 5-fluorouracil-based chemotherapy in patients with cancer. We herein investigated the differences in the mRNA levels of these enzymes in non-small-cell lung cancer (NSCLC) and evaluated their prognostic value for NSCLC treated by surgical resection. The intratumoral mRNA levels of , and were quantified in 66 patients with pathological stage I and II NSCLC (adenocarcinoma or squamous cell carcinoma) following complete resection according to the Danenberg Tumor Profile method. Read More

Oncol Lett 2018 Dec 28;16(6):7256-7263. Epub 2018 Sep 28.

Division of Thoracic Surgery, Japan Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan.

Cytokeratin 5/6 (CK5/6), p63, and p40 are commonly used as immunohistochemical markers for squamous cell carcinoma (SqCC) of the lung. To elucidate their positivity in primary pulmonary choriocarcinoma (PPC), the present study examined 4 PPCs, including 1 surgically removed PPC and 3 postmortem PPCs. All PPCs consisted of nested cytotrophoblastic tumor cells and occasional syncytiotrophoblastic tumor cells although 1 surgically removed PPC was markedly affected by pre-operative therapy-associated necrosis and 3 postmortem PPCs coexisted with adenocarcinoma. Read More

Oncol Lett 2018 Dec 3;16(6):7245-7255. Epub 2018 Oct 3.

Department of Oncology, University of Zagreb School of Medicine, Sisters of Mercy University Hospital Center, University Hospital for Tumors, 10000 Zagreb, Croatia.

Cancer/testis antigens (CTAs) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues, with the exception of the testes and placenta. Numerous immunohistochemical studies have reported associations between CTA expression and a negative estrogen receptor (ER) status in breast tumors, and demonstrated that CTAs are frequently expressed in tumors with higher nuclear grade. The expression of CTAs has not been studied as extensively in ductal carcinoma (DCIS) as it has been in invasive breast cancer. Read More

Oncol Lett 2018 Dec 3;16(6):7204-7211. Epub 2018 Oct 3.

Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Retinoblastoma-binding protein 7 (RBBP7) is an important component of several complexes that regulate chromatin metabolism. It is overexpressed in certain cancer types and serves conflicting roles in tumor progression. In the present study, the expression and roles of RBBP7 were explored in esophageal squamous cell carcinoma (ESCC). Read More

Oncol Lett 2018 Dec 26;16(6):7166-7174. Epub 2018 Sep 26.

Department of Obstetrics and Gynecology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, SK-03601 Martin, Slovakia.

Cervical cancer (CC) is the second most common type of cancer affecting the female population. The development of CC takes several years, and involves a precancerous stage known as cervical intraepithelial neoplasia (CIN). A key factor in the development of disease is the human papillomavirus (HPV) infection, which initiates carcinogenesis. Read More

Oncol Lett 2018 Dec 25;16(6):7139-7145. Epub 2018 Sep 25.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62. Read More

Oncol Lett 2018 Dec 10;16(6):7131-7138. Epub 2018 Oct 10.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, Shanghai 200031, P.R. China.

Laryngeal squamous cell carcinoma (LSCC) is currently a serious public health problem in China; thus, it is urgent to identify effective treatment strategies for this disease. Previous studies demonstrated that reactive oxygen species (ROS) serve important roles in the apoptosis of LSCC cells. It has also been indicated that carboplatin (CBDCA), a second-generation platinum compound with broad antineoplastic properties, is able to induce oxidative stress to produce ROS, which in turn promotes apoptosis. Read More

Oncol Lett 2018 Dec 27;16(6):7097-7101. Epub 2018 Sep 27.

Department of Cardio-Thoracic Surgery, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China.

The present study investigated the association between the G(-248)A single nucleotide polymorphism (SNP) in the promoter region of B-cell lymphoma 2 (Bcl-2) associated X protein (Bax), which is a pro-apoptosis gene and the clinicopathological parameters and prognosis of patients with esophagus cancer. Three genotypes (AA, AG and GG) of Bax G(-248)A SNP were detected in 75 patients with esophageal squamous cell carcinoma (ESCC) via polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). The expression of Bax in tumor tissues from 75 patients with ESCC and 30 para-carcinoma normal tissues were detected via immunohistochemistry. Read More

Oncol Lett 2018 Dec 26;16(6):7035-7047. Epub 2018 Sep 26.

Department of Molecular Virology, Adam Mickiewicz University, 61-712 Poznan, Poland.

Cervical microbial communities serve a crucial role in the persistence and development of oncogenic human papilloma virus (HPV) infections. In the present study, the authors hypothesised that disturbed heterogeneity of microbial flora was associated with HPV-induced carcinogenesis. Swabs of the cervical microbiota were collected from 250 women and the 16S ribosomal DNA was sequenced using a high throughput assay. Read More

Oncol Lett 2018 Dec 1;16(6):6998-7007. Epub 2018 Oct 1.

Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen, Guangdong 518120, P.R. China.

This article presented a case of a human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered-T cells (TCR-T cells) targeting the cancer-testis antigen NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well-tolerated with this therapy in the clinical trial. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):225-228

Department of Prosthodontics, Christian Dental College, Ludhiana, Punjab, India.

Squamous cell carcinoma (SCC) of the oral cavity is relatively common in the Indian subcontinent with surgical resection and adjuvant radiotherapy/chemotherapy being the treatment modality of choice. Prosthetic rehabilitation with an obturator following resection is more economical and yields satisfactory results. Better patient acceptance and comfort necessitates hollowing the prosthesis to a great extent. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

Oncogene 2018 Dec 13. Epub 2018 Dec 13.

Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

γδ T cells are a unique lymphocyte population that have been reported to have either anti- or pro-tumoral functions in several cancer types, but the mechanisms are underinvestigated. Exosomes, initially considered to be cellular "garbage dumpsters," are now implicated in mediating interactions with the cellular environment. Hypoxia is a common feature of solid tumors and is believed to alter tumor-derived exosomes (TEXs), which mediate the hypoxic evolution of the tumor microenvironment in return. Read More

Auris Nasus Larynx 2018 Dec 10. Epub 2018 Dec 10.

Departments of Otorhinolaryngology, Nagoya City University, Japan.

We report a rare case of sinonasal inverted papilloma (IP) associated with small cell neuroendocrine carcinoma (SNEC). To our knowledge, this is the first report to describe SNEC found during the treatment of sinonasal IP. Surgery and five cycles of cisplatin plus etoposide with concurrent intensity modulated radiation therapy were performed. Read More

Clin Radiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiology, Shengjing Hospital of China Medical University, Sanhao Street No36, Heping District, Shenyang, Liaoning 110004, China.

Aim: To explore the relationship between positron-emission tomography (PET) and intravoxel incoherent motion (IVIM) histogram parameters and their correlations with the clinicopathological features of cervical squamous cell cancer (CSCC).

Materials And Methods: Forty-four patients with CSCC underwent pelvic combined PET/magnetic resonance imaging (MRI) including IVIM sequences. The maximum/mean standardized uptake value (SUV/SUV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of PET, histogram parameters of apparent diffusion coefficient (ADC), IVIM biomarkers of tissue diffusivity (D), and perfusion fraction (F) were calculated. Read More

Cell Transplant 2018 Dec 14:963689718817478. Epub 2018 Dec 14.

4 Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Cervical liquid-based cytology plays an important role in the diagnosis of cervical squamous intraepithelial lesion (SIL). However, cytological evaluation alone has a relatively low sensitive. To overcome this problem, HPV DNA testing or HPV DNA combined with cytology has been applied. Read More

Molecules 2018 Dec 12;23(12). Epub 2018 Dec 12.

Radiobiology Lab, The Greater Poland Cancer Centre, Garbary 15 Str., 61-866 Poznan, Poland.

Fucoidans have been reported to exert anticancer effects with simultaneous low toxicity against healthy tissue. That correlation was observed in several cancer models, however, it has never been investigated in head and neck cancer before. To magnify the efficacy of conventional therapy, the administration of agents like fucoidan could be beneficial. Read More

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150, Seongan-ro Gangdong-Gu, Seoul 134-701, Korea.

Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approach that leverages publicly available independent genome-wide expression datasets. CSMD1-related genes were found and analyzed to examine the clinical significance of CSMD1 inactivation in the HNSCC cohort of publicly available databases. Read More

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.

High-risk human papillomaviruses (HPVs) have been identified as the main contributors to cervical cancer. Despite various diagnostic tools available, including the predominant Papanicolaou test (Pap test), technical limitations affect the efficiency of cervical cancer screening. The aim of this study was to evaluate the diagnostic performance of spliced HPV16 E6/E7 mRNA viral loads (VL) for grade 2 or higher cervical intraepithelial neoplasia diagnosis. Read More

Medicina (Kaunas) 2018 Dec 10;54(6). Epub 2018 Dec 10.

Oncology Institute of Lithuanian University of Health Sciences, Eivenių g. 2, 50009 Kaunas, Lithuania.

Induction chemotherapy (ICT) before definitive chemoradiation (CRT) gives high response rates in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). However, pre-ICT gross tumor volume (GTV) for radiotherapy (RT) planning is still recommended. As F-FDG PET/CT has an advantage of biological tumor information comparing to standard imaging methods, we aimed to evaluate the feasibility of F-FDG PET/CT-based post-ICT GTV delineation for RT planning in LA-SCCHN and to assess the prognostic value of PET parameters: maximum standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). Read More

J Clin Med 2018 Dec 10;7(12). Epub 2018 Dec 10.

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.

Zinc finger AN1-type containing 4 (ZFAND4) has emerged as a promising prognostic marker and predictor of metastasis for patients with oral squamous cell carcinoma (OSCC). However, further validation is fundamental before clinical implementation. Hence, this study evaluated the expression pattern of ZFAND4 protein expression by immunohistochemistry using an independent cohort of 125 patients with OSCC, and correlations with the clinicopathologic parameters and disease outcome. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13470

Department of Obstetrics and Gynecology.

In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20. Read More

J Am Acad Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address:

Background: There have been no studies of the American Academy of Dermatology's SPOTme skin cancer screening program that have collectively analyzed the factors associated with suspected diagnoses of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), dysplastic nevus (DN), and cutaneous melanoma (CM).

Objective: Describe the demographics, risk factors, and access to care profile associated with suspected diagnoses of BCC, SCC, DN, and CM among first-time SPOTme screenees from 2009 to 2010.

Methods: We conducted a cross-sectional analysis of data from SPOTme skin cancer screenings conducted in 2009 and 2010. Read More

Hinyokika Kiyo 2018 Nov;64(11):455-458

The Department of Pathology, National Hospital Organization Osaka Minami Medical Center.

A 75-year-old man with a history of early gastric cancer, phimosis and bronchial asthma experienced pain and palpated a mass in the penis in March 2015. After 2 months, he noticed bleeding from the tumor and visited our hospital. Pelvic computed tomography and magnetic resonance imaging revealed a pelvic tumor, bilateral lymphadenopathy, and para-aortic lymphadenopathy. Read More

Hinyokika Kiyo 2018 Oct;64(10):403-407

The Department of Pathology, Osaka Rosai Hospital.

We report a case of renal pelvic cancer found after left renal trauma. A 63-year-old man was admitted to our hospital because of gross hematuria after he had fallen down the stairs two days earlier. He had asymptomatic severe anemia (Hb : 3. Read More

PLoS One 2018 13;13(12):e0207934. Epub 2018 Dec 13.

HPV Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom.

The incidence of Human Papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing rapidly in the UK. Patients with HPV-positive OPSCC generally show superior clinical responses relative to HPV-negative patients. We hypothesised that these superior responses could be associated with defective repair of DNA double strand breaks (DSB). Read More

N Z Med J 2018 Dec 14;131(1487):23-29. Epub 2018 Dec 14.

Department of General Surgery, Whangarei Hospital, Northland; Consultant General and Colorectal Surgeon, Whangarei Hospital, Northland; Honorary Senior Lecturer, Department of Surgery, University of Auckland, Auckland.

Background: Non-melanoma skin cancer (NMSC) is the most commonly diagnosed and costly cancer in Australasia. Cutaneous squamous cell carcinoma (cSCC) accounts for approximately 25% of NMSC. A better understanding of predictors of close and positive margins following surgical excision will help guide treatment. Read More

Clin Oral Investig 2018 Dec 12. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Surgery, University of Erlangen-Nürnberg, Glückstrasse 11, 91054, Erlangen, Germany.

The following note was inadvertently omitted from the published paper: This work was performed in (partial) fulfillment of the requirements for the first author's obtaining the degree Dr. med. dent. Read More

J Cancer Res Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Science, The Wheatley School, Old Westbury, NY, USA.

Purpose: Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers.

Methods: Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP53 Database were analyzed to determine the distribution of germline and somatic mutations in the TP53 gene. Read More

Oncol Rep 2018 Oct 8. Epub 2018 Oct 8.

Department of Oral and Maxillofacial‑Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P.R. China.

Several putative biomarkers have been reported to identify cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). Herein, we aimed to demonstrate the validity and the underlying relationship for these biomarkers in HNSCC. Bioinformatic analyses for the reported CSC biomarkers of HNSCC were performed based on the TCGA primary HNSCC cohort using the UCSC Xena browser. Read More

Oncotarget 2018 Nov 13;9(89):35997-36011. Epub 2018 Nov 13.

Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

MAGE-A4 antigen is a cancer-testis antigen that is frequently expressed in tumor tissues. Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received a CHP-MAGE-A4 vaccine. Read More

Exp Ther Med 2018 Dec 2;16(6):4959-4966. Epub 2018 Oct 2.

College of Acupuncture and Massage, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China.

The aim of the present study was to examine microRNA (miRNA or miR)-455-5p expression in esophageal squamous cell carcinoma (ESCC) at the tissue and cellular levels in order to elucidate its biological roles. A total of 60 patients with ESCC were enrolled in the present study and reverse transcription-quantitative polymerase chain reaction was used to measure the expression of miR-455-5p. ESCC Eca109 cells were transfected with miR-NC, miR-455-5p mimics or inhibitor and a Cell Counting Kit-8 assay was used to assess proliferation. Read More

Exp Ther Med 2018 Dec 19;16(6):4879-4885. Epub 2018 Sep 19.

Department of Gastroenterology, Shanghai East Hospital, Tongji University, Shanghai 200123, P.R. China.

Increasing evidence indicates that long non-coding RNAs (lncRNAs) are closely associated with the progression of human cancer, including colorectal cancer (CRC). A previous study suggested that lncRNA LINC01503 promotes squamous cell carcinoma progression. However, the function of LINC01503 in CRC has remained elusive. Read More

Oncogene 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou,Guangdong, China.

Tumor-associated lymphangiogenesis has attracted increasing attention because of its potential contribution to lymph node metastasis. However, the molecular mechanisms underlying lymphangiogenesis in cancer remains elusive. In the current study, we demonstrate that tripartite motif-containing 3 (TRIM3) directly interacts with and induces E3 ligase-dependent proteasomal turnover of importin α3 and α-Actinin-4 (ACTN4), which controls nuclear factor kappa B (NF-κB) activity at a well-ordered level. Read More

Nihon Ronen Igakkai Zasshi 2018 ;55(4):679-685

Department of Respiratory Medicine, Tokyo Metropolitan Geriatric Hospital.

Background: Whether or not immune checkpoint inhibitors are safe and effective for the elderly remains unclear, even though these drugs were approved two years ago for the treatment of advanced non-small cell lung cancer in Japan. Older cancer patients are vulnerable to chemotherapy, so their life function should be closely monitored before starting, continuing, or discontinuing cancer treatment.

Case: An 85-year-old man showed a wedge-shaped shadow in the apical portion of the left lung on chest computed tomography. Read More

Proc Natl Acad Sci U S A 2018 Dec 12. Epub 2018 Dec 12.

Department of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany

Molecular subtyping of cancer offers tremendous promise for the optimization of a precision oncology approach to anticancer therapy. Recent advances in pancreatic cancer research uncovered various molecular subtypes with tumors expressing a squamous/basal-like gene expression signature displaying a worse prognosis. Through unbiased epigenome mapping, we identified deltaNp63 as a major driver of a gene signature in pancreatic cancer cell lines, which we report to faithfully represent the highly aggressive pancreatic squamous subtype observed in vivo, and display the specific epigenetic marking of genes associated with decreased survival. Read More

J Immunother Cancer 2018 Dec 12;6(1):147. Epub 2018 Dec 12.

Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 330 Cedar Street, New Haven, CT, 06510, USA.

Novel approaches with checkpoint inhibitors in immunotherapy continue to be essential in the treatment of non-small cell lung cancer (NSCLC). However, the low rate of primary response and the development of acquired resistance during the immunotherapy limit their long-term effectiveness. The underlying cause of acquired resistance is poorly understood; potential management strategies for patients with acquired resistance are even less clear. Read More

BMC Cancer 2018 Dec 12;18(1):1244. Epub 2018 Dec 12.

Departments of Surgery, College of Medicine, Hanyang University222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.

Background: SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppressive role of SSBP2, which is silenced by promoter hypermethylation in several human malignancies, such as hematologic malignancies, prostate cancer, esophageal squamous cell carcinoma, ovarian cancer, and gallbladder cancer. However, an oncogenic role of SSBP2 has been suggested in glioblastoma patients. Read More

Klin Onkol 2018 ;31(4):296-300

Background: Primary branchiogenic carcinoma (BC) is an exceptional diagnostic entity. In most cases, suspicion of BC is confirmed to be a cystic lymph node metastasis of an occult primary tumor. Martin and Khafif therefore established diagnostic criteria, emphasizing above all the importance of a histologically assessed transformation of cystic lining epithelium into an invasive squamous cell carcinoma in one pathological lesion after the exclusion of a primary tumor. Read More

Curr Health Sci J 2015 Oct-Dec;41(4):401-405. Epub 2015 Dec 22.

Department of ENT, Emergency Hospital Grigore Alexandrescu, București, Romania.

The basaloid carcinoma is a rare and distinct type of squamous carcinoma. Of all the squamous carcinomas, the basaloid tumor is noted for its high aggressivity and fast replication rate. It is usually discovered within the upper levels of the larynx (supraglottis), the tongue base or the piriform sinuses in male patients ranging from sixty to eighty years old. Read More

Proteomics Clin Appl 2018 Dec 7:e1800158. Epub 2018 Dec 7.

Institute of Pathology, University of Heidelberg, Heidelberg, Germany.

Purpose: Identification of proteolytic peptides from matrix-assisted laser desorption/ionization (MALDI) imaging still remains a challenge. In-situ post source decay leads to low fragmentation yields, so identification is often impaired. Liquid chromatography tandem mass spectrometry (LC-MS/MS) is an alternative to in-situ MS/MS, but leads to multiple identification candidates for a given mass. Read More

Environ Toxicol Chem 2018 Dec 7. Epub 2018 Dec 7.

Department of Animal Science, Michigan State University, East Lansing, Michigan, USA.

A jaw lesion reported in mink exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD-like chemicals has been considered a potential indicator of exposure to these chemicals. TCDD-like chemicals induce many of their effects through interaction with the aryl hydrocarbon receptor. The present report indicates that mink dosed with β-naphthoflavone, which is an aryl hydrocarbon receptor ligand but not a TCDD-like chemical, also develop the lesion. Read More

FEBS Open Bio 2018 Dec 31;8(12):1953-1963. Epub 2018 Oct 31.

Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Changchun Jilin China.

Oral squamous cell carcinoma (OSCC) is one of the most common head and neck malignancies. Advanced stages of the disease are associated with poor survival, highlighting a need for new treatment modalities. We previously showed that the proinflammatory cytokine interleukin-18 (IL-18) has a tumor suppressive role in OSCC. Read More

Oncoimmunology 2018 21;7(12):e1496880. Epub 2018 Sep 21.

Univ Lyon, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Lyon, France.

Oral squamous cell carcinoma (OSCC) is a major cause of cancer-associated morbidity and mortality and may develop from oral premalignant lesions (OPL). An improved molecular classification of OPL may help refining prevention strategies. We identified two main OPL gene-expression subtypes, named immunological and classical, in 86 OPL (discovery dataset). Read More