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    The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer.
    Biomed Pharmacother 2017 Aug 18;95:55-61. Epub 2017 Aug 18.
    Department of Oncology, Chest Hospital of Hebei Province, Shijiazhuang 050041, PR China.
    Tumor-infiltrating immune cells are closely associated with clinical outcome. However, immunohistochemistry-based analysis of tumor infiltrates can be misleading as the representative marker of an immune subpopulation might be expressed in other cell types. In this study, based on a metagene approach (known as CIBERSORT) and an online databse, The Cancer Immunome Atlas (https://tcia. Read More

    LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression.
    Cancer Lett 2017 Aug 17. Epub 2017 Aug 17.
    Institute of Cancer Stem Cell& College of Stomatology, Dalian Medical University, Dalian 116044, China. Electronic address:
    Increasing evidence has revealed the aberrant expression of long non-coding RNAs (lncRNAs) in many cancer types, including oral squamous cell carcinoma (OSCC). However, limited investigations report metastasis-related lncRNAs in OSCC. Herein, we report the identification of dysregulated intergenic lncRNAs in the highly metastatic OSCC cell line, UM-SCC6H. Read More

    Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.
    Cancer Lett 2017 Aug 17. Epub 2017 Aug 17.
    Department of Molecular Oncology, School of Medicine, Chiba University, Japan. Electronic address:
    Oropharyngeal squamous cell carcinoma (OPSCC) incidence has increased dramatically due to human papillomavirus (HPV); however, associated epigenetic alterations are not well studied. We performed genome-wide DNA methylation analysis using an Infinium 450k BeadArray for clinical OPSCC and non-cancerous samples and cancer cell lines with/without 5-aza-2'-deoxycytidine and/or trichostatin A treatment. Frequent promoter hypermethylation and methylation-associated silencing were detected in 144 genes, which included those involved in cell-cell signaling and neuron differentiation. Read More

    AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.
    Cancer Lett 2017 Aug 17. Epub 2017 Aug 17.
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. Electronic address:
    In this study, we expanded our recent work showing that ASCT2, a Na+-dependent neutral amino acid transporter that is a major transporter of glutamine uptake in cancer cells, is physically associated with EGFR in human head and neck squamous cell carcinoma cells and in several other types of cancer cells. We found in our current study that ASCT2 can be downregulated by cetuximab, an approved anti-EGFR therapeutic antibody, via cetuximab-induced EGFR endocytosis independently of cetuximab-mediated inhibition of EGFR tyrosine kinase. We further found that ASCT2-EGFR association involves the adaptor-related protein complex 1 gamma 1 subunit (AP1G1), a subunit of clathrin-associated adaptor protein complex 1, which plays a role in membrane protein sorting in endosomes after receptor-mediated endocytosis. Read More

    Marginal or segmental mandibulectomy: treatment modality selection for oral cancer: a systematic review and meta-analysis.
    Int J Oral Maxillofac Surg 2017 Aug 17. Epub 2017 Aug 17.
    Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China. Electronic address:
    Surgery is the most well established mode of initial definitive treatment for the majority of oral cancers. The most important decision in terms of tumour ablation in oral cancers when the jaws are potentially involved is the management of the mandible. The aim of this study was to explore the differences in survival rate and disease control between patients undergoing marginal mandibulectomy and patients undergoing segmental mandibulectomy using a systematic review and meta-analysis approach. Read More

    Epidemiology of Esophageal Squamous Cell Carcinoma.
    Gastroenterology 2017 Aug 17. Epub 2017 Aug 17.
    Department of Epidemiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
    Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of the 456,000 incident esophageal cancers each year. Regions of high incidence include Eastern to Central Asia, along the Rift Valley in East Africa, and into South Africa. There are many causes of ESCC, which vary among regions. Read More

    Analysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma - Retrospective analysis of 517 patients.
    J Craniomaxillofac Surg 2017 Jul 27. Epub 2017 Jul 27.
    Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Cologne, Germany; Centre of Integrated Oncology (CIO) Cologne-Bonn, Germany.
    Introduction: Recurrence is one of the main reasons for poor prognosis of OSCC. The mortality rate is approximately 90% and the 5-year overall survival rate decreases from 90% to 30% when recurrence is diagnosed. Identification of clinicopathological risk factors predicting recurrence may be helpful for patient individualized management and improvement of therapy. Read More

    Antitumor activity of the dual PI3K/MTOR inhibitor, PF-04691502, in combination with radiation in head and neck cancer.
    Radiother Oncol 2017 Aug 16. Epub 2017 Aug 16.
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, United States. Electronic address:
    Background And Purpose: Head and neck squamous cell carcinoma (HNSCC) remains a clinical challenge where new treatments are required to supplement the current-standard-of care of concurrent chemoradiation. The PI3K/AKT/MTOR pathway has been identified from several next generation DNA sequencing studies to be commonly altered and activated in HNSCC.

    Material And Methods: In this study we investigated the activity of PF-04691502, an orally active ATP-competitive, dual inhibitor of PI3K and mTOR, in combination with a clinically relevant fractionated radiation treatment in two contrasting, well characterized, low passage HNSCC models. Read More

    Phloretin-loaded fast dissolving nanofibers for the locoregional therapy of oral squamous cell carcinoma.
    J Colloid Interface Sci 2017 Aug 12;508:112-120. Epub 2017 Aug 12.
    College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea. Electronic address:
    Fast dissolving nanofiber (NF) composed of poly(vinyl alcohol) (PVA) and d-α-tocopheryl polyethylene glycol succinate (TPGS) was developed for locoregional delivery of phloretin to oral cancers. PVA/TPGS/phloretin NF with 321nm mean diameter and >90% drug entrapment efficiency was fabricated by an electrospinning method. Transformation of drug from crystalline to amorphous state was identified by solid-state studies. Read More

    mTOR co-targeting strategies for head and neck cancer therapy.
    Cancer Metastasis Rev 2017 Aug 18. Epub 2017 Aug 18.
    Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. There is an urgent need to develop effective therapeutic approaches to prevent and treat HNSCC. Recent deep sequencing of the HNSCC genomic landscape revealed a multiplicity and diversity of genetic alterations in this malignancy. Read More

    Modifiable factors and esophageal cancer: a systematic review of published meta-analyses.
    J Gastroenterol 2017 Aug 18. Epub 2017 Aug 18.
    EPIUnit-Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-600, Porto, Portugal.
    There are marked differences in the etiology of the major histological types of esophageal cancer (EC)-squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). Read More

    The prognostic impact of combined pulmonary fibrosis and emphysema in patients with clinical stage IA non-small cell lung cancer.
    Surg Today 2017 Aug 18. Epub 2017 Aug 18.
    Department of Thoracic Surgery, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Jigyohama 1-chome, 8-1, Chuo-ku, Fukuoka, 810-8563, Japan.
    Purpose: We evaluated the long-term outcomes of clinical stage IA non-small cell lung cancer (NSCLC) patients with combined pulmonary fibrosis and emphysema (CPFE) who underwent lobectomy.

    Methods: We reviewed the chest computed tomography (CT) findings and divided the patients into normal, fibrosis, emphysema and CPFE groups. We evaluated the relationships among the CT findings, the clinicopathological findings and postoperative survival. Read More

    Identification of α-enolase as a prognostic and diagnostic precancer biomarker in oral submucous fibrosis.
    J Clin Pathol 2017 Aug 18. Epub 2017 Aug 18.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India.
    Aims: Diagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF.

    Methods: The high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistry (IHC), Western blot (WB) and real-time PCR (RT-PCR) analysis are considered for such biomarker identification and multilevel validations. Read More

    Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma.
    Cancer Prev Res (Phila) 2017 Aug 18. Epub 2017 Aug 18.
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, United Kingdom.
    Basal cells are stem/progenitor cells that maintain airway homeostasis, enact repair following epithelial injury, and are a candidate cell-of-origin for lung squamous cell carcinoma. Heterogeneity of basal cells is recognized in terms of gene expression and differentiation capacity. In this Issue, Pagano and colleagues isolate a subset of immortalized basal cells that are characterized by high motility, suggesting that they might also be heterogeneous in their biophysical properties. Read More

    Nrf2 regulates cellular behaviors and Notch signaling in oral squamous cell carcinoma cells.
    Biochem Biophys Res Commun 2017 Aug 15. Epub 2017 Aug 15.
    Cancer Research Program, JLC-BBRI, North Carolina Central University, Durham, NC 27707, USA. Electronic address:
    Oxidative stress is known to play a pivotal role in the development of oral squamous cell carcinoma (OSCC). We have demonstrated that activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway has chemopreventive effects against oxidative stress-associated OSCC. However, Nrf2 have dual roles in cancer development; while it prevents carcinogenesis of normal cells, hyperactive Nrf2 also promotes the survival of cancer cells. Read More

    Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia.
    Am J Clin Pathol 2017 Sep;148(3):264-273
    Departments of Pathology.
    Objectives: Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). K17, however, has not been previously evaluated in endocervical glandular neoplasia. Based on the similar pathogenesis of squamous and glandular lesions of the cervix, we hypothesized that K17 overexpression could also be a diagnostic and/or prognostic biomarker for endocervical neoplasia. Read More

    Comparison of PET and CT radiomics for prediction of local tumor control in head and neck squamous cell carcinoma.
    Acta Oncol 2017 Aug 18:1-6. Epub 2017 Aug 18.
    a Department of Radiation Oncology , University Hospital Zurich and University of Zurich , Zurich , Switzerland.
    Purpose: An association between radiomic features extracted from CT and local tumor control in the head and neck squamous cell carcinoma (HNSCC) has been shown. This study investigated the value of pretreatment functional imaging (18F-FDG PET) radiomics for modeling of local tumor control.

    Material And Methods: Data from HNSCC patients (n = 121) treated with definitive radiochemotherapy were used for model training. Read More

    Review of periorbital nerve enlargement and biopsy techniques.
    Orbit 2017 Aug 18:1-5. Epub 2017 Aug 18.
    a Department of Ophthalmology , Emory University , Atlanta , Georgia , USA.
    Periorbital nerve enlargement commonly indicates perineural invasion of malignancy or inflammatory conditions. This study reviews the role of supraorbital and infraorbital nerve biopsies in patients presenting with radiographic enlargement and to elucidate the surgical technique involved. A retrospective chart review (1997-2014) was performed at a single tertiary center. Read More

    Sympathetic ophthalmia related to conjunctival invasive squamous-cell carcinoma.
    Indian J Ophthalmol 2017 Aug;65(8):741-743
    Department of Ophthalmology, Hospital de Santa Maria; Visual Sciences Study Center, CECV, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
    Sympathetic ophthalmia (SO) is a rare, diffuse, bilateral, and granulomatous nonnecrotizing panuveitis that may follow intraocular penetrating trauma. Our aim is to report a rare case of SO following orbital exenteration. Orbital exenteration was performed on a 48-year-old african female due to conjunctival keratinizing squamous cell carcinoma with intraocular involvement of the left eye. Read More

    Targeting metabolic pathways for head and neck cancers therapeutics.
    Cancer Metastasis Rev 2017 Aug 17. Epub 2017 Aug 17.
    Department of Metabolism and Nutrition, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
    Cancer cells have distinctive energy metabolism pathways that support their rapid cell division. The preference for anaerobic glycolysis under the normal oxygen condition is known as the Warburg effect and has been observed in head and neck cancers. These metabolic changes are controlled by cancer-related transcription factors, such as tumor suppressor gene and hypoxia inducible factor 1α. Read More

    Flow Cytometric Detection of Circulating Tumor Cells Using a Candidate Stem Cell Marker, p75 Neurotrophin Receptor (p75NTR).
    Methods Mol Biol 2017 ;1634:211-217
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimo-Adachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
    The most widely studied detection for circulating tumor cells (CTCs) in peripheral blood of cancer patients has been based on immunomagnetic enrichment using antibodies against epithelial cell adhesion molecule (EpCAM), which is overexpressed in epithelial cells. A neurotrophin receptor p75 (p75NTR) is expressed in a candidate stem cell fraction in esophageal squamous cell carcinoma (ESCC), which shows significantly higher colony formation, enhanced tumor formation in mice, along with strong expression of epithelial mesenchymal transition-related genes. Here, we describe a method to detect CTCs in ESCC based on the combined expression of EpCAM and p75NTR using flow cytometry, demonstrating the feasibility of expression analysis of multiple cell surface markers in viable cells. Read More

    [Malignant teratoma: about a case and a review of the literature].
    Pan Afr Med J 2017 29;27:61. Epub 2017 May 29.
    Service d'Anatomopathologie du Centre Hospitalier National (CHN) de Nouakchott, Mauritanie.
    Dermoid cysts account for 10-20% of ovarian germ cell tumors. Malignant transformation within ovarian dermoid cyst has been reported in 1-2 per cent of the cases. The treatment remains controversial. Read More

    DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma.
    J Cancer 2017 22;8(12):2410-2416. Epub 2017 Jul 22.
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou.
    Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is known to function in several types of cancer. In this study, we investigated the expression and clinicopathologic significance of DNA-PKcs in laryngeal squamous cell carcinoma (LSCC). Methods: We conducted a retrospective study of 208 patients with advanced-stage LSCC treated at Sun Yat-sen University Cancer Center, Guangzhou, China. Read More

    Interferon-α Promotes the Expression of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma.
    J Cancer 2017 22;8(12):2384-2393. Epub 2017 Jul 22.
    Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
    Objectives: IFNα can stimulate an antitumor immune response and has a direct inhibition on cancer cells. This study is to test whether IFNα can activate dormant cancer stem cell (CSC) in oral squamous cell carcinoma (OSCC) to facilitate their elimination by chemotherapy. Materials and methods: Nude mouse transplantation tumor model was established and administrated with IFNα and saline. Read More

    MicroRNA-204-5p inhibits invasion and metastasis of laryngeal squamous cell carcinoma by suppressing forkhead box C1.
    J Cancer 2017 21;8(12):2356-2368. Epub 2017 Jul 21.
    Department of Otolaryngology, Head & Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
    Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box C1 (FOXC1), in human LSCC and explore their roles in the malignant behaviors of LSCC Hep-2 and TU-177 cells. Methods: The regulatory effects of miR-204-5p on the 3' untranslated region of FOXC1 predicted by bioinformatics were tested by dual-luciferase reporter assay. Read More

    Development and Validation of a Serum Biomarker Panel for the Detection of Esophageal Squamous Cell Carcinoma through RNA Transcriptome Sequencing.
    J Cancer 2017 21;8(12):2346-2355. Epub 2017 Jul 21.
    State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
    Serum tumor markers for the diagnosis of esophageal squamous cell carcinoma (ESCC) have low sensitivity. This study aims to identify new serum markers for ESCC diagnosis from RNA sequencing (RNA-seq) data. RNA-seq was performed using six pairs of ESCC and matched normal tissues. Read More

    Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance.
    J Cancer 2017 21;8(12):2336-2345. Epub 2017 Jul 21.
    Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China.
    Derlin-1 is over-expressed to function as an oncoprotein in breast, lung and colon cancers. However, the implications of Derlin-1 involved in squamous cell carcinoma of the head and neck (SCCHN) remain unknown. This study aims to investigate the effects of Derlin-1 expression on SCCHN tissues and cells. Read More

    Adjuvant Therapeutic Modalities Following Three-field Lymph Node Dissection for Stage II/III Esophageal Squamous Cell Carcinoma.
    J Cancer 2017 5;8(11):2051-2059. Epub 2017 Jul 5.
    Departments of Radiation Oncology and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 32500.
    Background: The rates of locoregional and distant recurrence for esophageal squamous cell carcinoma (ESCC) patients underwent radical esophagectomy remain high. The purpose of this study is to explore an optimal postoperative therapeutic modality by investigating the efficacy of various adjuvant therapies in the treatment of ESCC. Methods: We retrospectively reviewed 408 ESCC patients underwent thoracic esophagectomy and 3-field lymph node dissection from 2010 to 2015. Read More

    Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.
    J Cancer 2017 5;8(11):2033-2041. Epub 2017 Jul 5.
    Department of Oral Science, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
    Activin B, a homodimer of inhibin beta b (INHBB), is a multifunctional cytokine belonging to the transforming growth factor-β (TGF-β) family. However, the molecular functions and clinical relevance of activin B have not been determined in oral cancer. We investigated the critical roles of activin B in oral squamous cell carcinoma (OSCC). Read More

    Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration.
    J Cancer 2017 5;8(11):1943-1951. Epub 2017 Jul 5.
    Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
    Oral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastatic potential. However, no good biomarker has been identified to refine which subtype is of high metastatic potential to make decisions regarding the elective and therapeutic management of lymphatic metastases. In this study, we investigated the role of the metabolic enzyme phosphoglycerate mutase 1 (PGAM1) in OSCC. Read More

    Low Preoperative albumin-to-globulin ratio Predict Poor Survival and Negatively Correlated with Fibrinogen in Resectable Esophageal Squamous Cell Carcinoma.
    J Cancer 2017 2;8(10):1833-1842. Epub 2017 Jul 2.
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Clinical Laboratory Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
    Background: Although various inflammation-based indexes in esophageal carcinoma have been documented, but the prognostic value of the albumin-to-globulin ratio(AGR) and its correlation with fibrinogen in resectable ESCC remain unknown. Methods: The levels of pre-treatment serum common acute phase proteins (including CRP, albumin and fribrinogen) were retrospectively analyzed in 447 patients with ESCC who underwent surgical resection at our department. The prognostic value was explored by univariate and multivariate cox hazard analysis. Read More

    Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma.
    Sci Rep 2017 Aug 17;7(1):8649. Epub 2017 Aug 17.
    Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea.
    We examined the prognostic significance of Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3) expression and its correlations with mesenchymal phenotype and microvessel density in non-small cell lung carcinoma (NSCLC). A total of 268 NSCLC specimens were evaluated retrospectively by immunohistochemical staining for EDIL3, EMT markers (e-cadherin, β-catenin, and vimentin), and CD31 to measure microvessel density. EDIL3, e-cadherin, β-catenin, and vimentin were expressed in 16%, 22. Read More

    Clinical significance of SPARC in esophageal squamous cell carcinoma.
    Biochem Biophys Res Commun 2017 Aug 14. Epub 2017 Aug 14.
    Department of Orthopaedics, First Affiliated Hospital of Shantou University Medical College, No.57 Changping Road, Shantou, Guangdong 515041, China. Electronic address:
    Background: Secreted protein acidic and rich in cysteine (SPARC) is matricellular protein that modulates interactions between cells and the extracellular matrix. The role of SPARC in carcinogenesis is controversialin that SPARC can be a tumor suppressor, but overexpression of SPARC is associated with poorer prognosis.

    Methods: We collected 145 esophageal squamous cell carcinoma and adjacent normal tissues in Shantou, a high incidence region for esophageal cancer. Read More

    Glansectomy as Primary Management of Penile Squamous Cell Carcinoma: an International Study Collaboration.
    Urology 2017 Aug 14. Epub 2017 Aug 14.
    Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
    Objective: To analyze the recurrence and survival outcomes of glansectomy in patients with penile squamous cell carcinoma.

    Materials And Methods: We performed a retrospective review of 410 patients across 5 international tertiary referral centers between 1999 and 2016. All patients had tumors involving the glans penis and underwent glansectomy as primary treatment. Read More

    Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma.
    J Dermatol Sci 2017 Aug 5. Epub 2017 Aug 5.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Background: Dynamin-related protein 1 (Drp1) mediates mitochondrial fission. Recently, several studies have shown that Drp1 plays an important role in some cancers. However, little is known about Drp1 in cutaneous squamous cell carcinoma (SCC). Read More

    Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options.
    J Otolaryngol Head Neck Surg 2017 Aug 17;46(1):52. Epub 2017 Aug 17.
    Department of Otorhinolaryngology, Head and Neck Surgery at UT Health McGovern Medical School, Houston, TX, USA.
    Background: Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differentiation leading to tumorigenesis. Although surgical intervention can remove such tumors, the potential for an etiologic field effect with recurrent disease is real. Read More

    Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review.
    Chin J Cancer 2017 Aug 17;36(1):65. Epub 2017 Aug 17.
    Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Science Building, No.17 Panjiayuan Nanli, Chaoyang District, PO Box 2258, Beijing, 100021, P. R. China.
    Background: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy, with a high incidence and poor prognosis. In the past several decades, hundreds of proteins have been reported to be associated with the prognosis of ESCC, but none has been widely accepted to guide clinical care. This study aimed to identify proteins with great potential for predicting prognosis of ESCC. Read More

    Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48.
    Integr Cancer Ther 2017 Sep 10;16(3):414-425. Epub 2016 Nov 10.
    3 Department of Oro-maxillofacial Surgical & Medical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
    Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Read More

    GTSP1 expression in non-smoker and non-drinker patients with squamous cell carcinoma of the head and neck.
    PLoS One 2017 17;12(8):e0182600. Epub 2017 Aug 17.
    Department of Internal Medicine, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
    Introduction: The main risk factors for head and neck squamous cell carcinoma (HNSCC) are tobacco and alcohol consumption and human papillomavirus (HPV) infection. However, in a subset of patients, no risk factors can be identified. Glutathione S-transferase π (GTSP1) is a carcinogen-detoxifying enzyme that is activated by exposure to carcinogens, and it is associated with a reduction in response to toxic therapies. Read More

    Combined high-intensity local treatment and systemic therapy in metastatic head and neck squamous cell carcinoma: An analysis of the National Cancer Data Base.
    Cancer 2017 Aug 17. Epub 2017 Aug 17.
    Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
    Background: There is increasing evidence that primary tumor ablation can improve survival for some cancer patients with distant metastases. This may be particularly applicable to head and neck squamous cell carcinoma (HNSCC) because of its tropism for locoregional progression.

    Methods: This study included patients with metastatic HNSCC undergoing systemic therapy identified in the National Cancer Data Base. Read More

    Reflectance Confocal Microscopy Criteria of Pigmented Squamous Cell Carcinoma In Situ.
    Am J Dermatopathol 2017 Aug 9. Epub 2017 Aug 9.
    *Department of Dermatology, University of Connecticut Health Center, Farmington, CT; †Department of Dermatology, Miller School of Medicine, University of Miami, Miami, FL; and ‡Department of Dermatology, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Pigmented squamous cell carcinoma in situ (pSCCis) is difficult to diagnose based on clinical and dermoscopic examination. Reflectance confocal microscopy (RCM) allows noninvasive differentiation between malignant and benign pigmented skin lesions. We determined the frequency of key RCM features of pSCCis and correlated the RCM criteria with the corresponding dermoscopic and histopathologic criteria. Read More

    Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas.
    J Pathol 2017 Aug 17. Epub 2017 Aug 17.
    Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.
    Adenosquamous carcinoma of the pancreas (ASCP) is a mixed tumor type which contains squamous cell carcinoma and also ductal adenocarcinoma components. Due to the rarity of this malignancy, only very limited genomic profiling has been performed. A recent paper by Fang et al. Read More

    [Percutaneous biopsy of the renal masses under ultrasound: a single-center 14 years experience].
    Beijing Da Xue Xue Bao 2017 Aug;49(4):617-621
    Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center; Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center, Beijing 100034, China.
    Objective: To assess the diagnostic rate, safety and clinical application of percutaneous renal masses biopsy for advanced renal cell carcinoma patients.

    Methods: In this retrospective study, we collected the data of renal masses from the patients who underwent renal masses biopsy under ultrasound from April 2001 to December 2014 in Peking University First Hospital. A total of 75 patients who were undiagnosed or diagnosed with advanced renal cell carcinoma by the imageological method were enrolled in this study. Read More

    Lymphocyte Nadir and Esophageal Cancer Survival Outcomes After Chemoradiation Therapy.
    Int J Radiat Oncol Biol Phys 2017 Sep 1;99(1):128-135. Epub 2017 Jun 1.
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:
    Purpose: Host immunity may affect the outcome in patients with esophageal cancer. We sought to identify factors that influenced absolute lymphocyte count (ALC) nadir during chemoradiation therapy (CRT) for esophageal cancer (EC) and looked for clinically relevant associations with survival.

    Methods And Materials: 504 patients with stage I-III EC (2007-2013) treated with neoadjuvant or definitive CRT with weekly ALC determinations made during treatment were analyzed. Read More

    iTRAQ-Based Quantitative Proteomic Analyses of High Grade Esophageal Squamous Intraepithelial Neoplasia.
    Proteomics Clin Appl 2017 Aug 16. Epub 2017 Aug 16.
    Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao, China, 210009.
    Purpose: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and is the fourth most lethal cancer in China. Little is known about the proteome of high grade esophageal squamous intraepithelial neoplasia (HGN), which is a premalignant lesion of ESCC.

    Experimental Design: A quantitative proteomic analysis using an Isobaric Tags for Relative and Absolute Quantification (iTRAQ) approach was used to characterize the protein expression profiles in HGN. Read More

    Response assessment after induction chemotherapy for head and neck squamous cell carcinoma: From physical examination to modern imaging techniques and beyond.
    Head Neck 2017 Aug 17. Epub 2017 Aug 17.
    Coordinator of the International Head and Neck Scientific Group.
    Significant correlations between the response to induction chemotherapy and success of subsequent radiotherapy have been reported and suggest that the response to induction chemotherapy is able to predict a response to radiotherapy. Therefore, induction chemotherapy may be used to tailor the treatment plan to the individual patient with head and neck cancer: following the planned subsequent (chemo)radiation schedule, planning a radiation dose boost, or reassessing the modality of treatment (eg, upfront surgery). Findings from reported trials suggest room for improvement in clinical response assessment after induction chemotherapy, but an optimal method has yet to be identified. Read More

    Circulating tumor cells in patients with head and neck squamous cell carcinoma: Feasibility of detection and quantitation.
    Head Neck 2017 Aug 17. Epub 2017 Aug 17.
    Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
    Background: The purpose of this study was to present our findings that because circulating tumor cells (CTCs) exist in extremely low numbers, their detection and quantification are challenging.

    Methods: Peripheral blood samples were collected from 32 patients with head and neck squamous cell carcinoma (HNSCC), and were subjected to the CellSieve Microfiltration Assay using a low-pressure filtration system. The CTCs captured by the filter were stained with an antibody cocktail (anti-cytokeratin (CK) 8, 18, and 19, anti-epithelial cell adhesion molecule (EpCAM), and anti-CD45 antibodies). Read More

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