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    148707 results match your criteria Squamous Cell Carcinoma

    1 OF 2975

    Quantifying the polygenic contribution to cutaneous squamous cell carcinoma risk.
    J Invest Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA; Department of Dermatology, Massachusetts General Hospital, Boston MA. Electronic address:
    Genetic factors play an important role in cutaneous squamous cell carcinoma (cSCC) risk. Genome-wide association studies have identified 21 single nucleotide polymorphisms (SNPs) associated with cSCC risk. Yet no studies have attempted to quantify the contribution of heritability to cSCC risk by calculating the population attributable risk (PAR) using a combination of all discovered genetic variants. Read More

    Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer.
    Biochem Biophys Res Commun 2018 Feb 13. Epub 2018 Feb 13.
    Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China; Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China. Electronic address:
    Exosomes are membrane-bound, virus-size vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell Immunoglobulin- and Mucin-domain-containing molecule 3 (Tim-3) is one of the next generation immune checkpoints and can be activated by its ligand Galectin-9, negatively regulating anti-tumor immune response. Read More

    Patterns of care and outcomes of adjuvant therapy for high-risk head and neck cancer after surgery.
    Head Neck 2018 Feb 16. Epub 2018 Feb 16.
    Department of Veterans Affairs New York Harbor Healthcare System, New York, New York.
    Background: Postoperative chemoradiotherapy (CRT) is considered standard of care in patients with locally advanced head and neck cancer with positive margins and/or extracapsular extension (ECE).

    Methods: The National Cancer Data Base (NCDB) was queried to identify patients with squamous cell carcinoma of the head and neck with stages III to IVB disease or with positive margins and/or ECE diagnosed between 2004 and 2012 receiving postoperative radiotherapy (RT). Using univariable and multivariable logistic and Cox regression, we assessed for predictors of CRT use and covariables impacting overall survival (OS), including in a propensity-matched subset. Read More

    Association of an intact E2 gene with higher HPV viral load, higher viral oncogene expression, and improved clinical outcome in HPV16 positive head and neck squamous cell carcinoma.
    PLoS One 2018 16;13(2):e0191581. Epub 2018 Feb 16.
    Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, United States of America.
    To assess the relationship of E2 gene disruption with viral gene expression and clinical outcome in human papillomavirus (HPV) positive head and neck squamous cell carcinoma, we evaluated 31 oropharyngeal and 17 non-oropharyngeal HPV16 positive carcinomas using two PCR-based methods to test for disruption of E2, followed by Sanger sequencing. Expression of HPV16 E6, E7 and E2 transcripts, along with cellular ARF and INK4A, were also assessed by RT-qPCR. Associations between E2 disruption, E2/E6/E7 expression, and clinical outcome were evaluated by Kaplan-Meier analysis for loco-regional recurrence and disease-specific survival. Read More

    A rare case of ectopic papillary thyroid carcinoma transformed into squamous cell carcinoma.
    Pathol Int 2018 Feb 16. Epub 2018 Feb 16.
    Department of Diagnostic Pathology, Osaka Police Hospital.
    A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. Read More

    Radiomic signature as a diagnostic factor for histologic subtype classification of non-small cell lung cancer.
    Eur Radiol 2018 Feb 15. Epub 2018 Feb 15.
    School of Life Science and Technology, XIDIAN University, Xi'an, Shanxi, China.
    Objectives: To distinguish squamous cell carcinoma (SCC) from lung adenocarcinoma (ADC) based on a radiomic signature METHODS: This study involved 129 patients with non-small cell lung cancer (NSCLC) (81 in the training cohort and 48 in the independent validation cohort). Approximately 485 features were extracted from a manually outlined tumor region. The LASSO logistic regression model selected the key features of a radiomic signature. Read More

    Mixed malignant mullerian tumor with neuroendocrine features in an irradiated uterus for cervical carcinoma. A unique association? A morphological, immunohistochemisty and ultrastructural study.
    Pathologica 2017 Dec;109(4):392-397
    Pathology, Department of Surgical Science and Integrated Diagnostics, University of Genoa.
    Chemo-radiation represents an effective therapy for carcinoma of the uterine cervix. The endometrium may however receive a consistent dose of mutagenic radiations and patients may have an increased risk of secondary malignancies. Endometrial mixed malignant mullerian tumor (MMMT) is a rare, highly aggressive disease, and neuroendocrine features are even rarer. Read More

    MRI with DWI for the Detection of Posttreatment Head and Neck Squamous Cell Carcinoma: Why Morphologic MRI Criteria Matter.
    AJNR Am J Neuroradiol 2018 Feb 15. Epub 2018 Feb 15.
    From the Division of Radiology (A.A., P.M., T.D.P., P.-A.P., M.B.), Department of Imaging and Medical Informatics
    Background And Purpose: Although diffusion-weighted imaging combined with morphologic MRI (DWIMRI) is used to detect posttreatment recurrent and second primary head and neck squamous cell carcinoma, the diagnostic criteria used so far have not been clarified. We hypothesized that precise MRI criteria based on signal intensity patterns on T2 and contrast-enhanced T1 complement DWI and therefore improve the diagnostic performance of DWIMRI.

    Materials And Methods: We analyzed 1. Read More

    Prognostic Significance of Human Papilloma Virus and p16 Expression in Patients with Vulvar Squamous Cell Carcinoma who Received Radiotherapy.
    Clin Oncol (R Coll Radiol) 2018 Feb 12. Epub 2018 Feb 12.
    Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:
    Aims: Human papilloma virus (HPV) has been identified as an aetiological agent in a subset of patients with vulvar squamous cell carcinoma (VSCC). The prognostic role of HPV status in VSCC patients treated with radiotherapy has not yet been determined. We investigated the associations between HPV, p16 and clinical outcome in these women. Read More

    Genetic and epigenetic alterations in the tumour, tumour margins, and normal buccal mucosa of patients with oral cancer.
    Int J Oral Maxillofac Surg 2018 Feb 12. Epub 2018 Feb 12.
    Institute of Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia. Electronic address:
    Despite adequate surgical resection, oral squamous cell carcinoma (OSCC) shows a high rate of recurrence and metastasis, which could be explained by the presence of molecular alterations in seemingly normal tumour margins and the entire oral mucosa. The aims of this study were (1) to assess the presence of gene amplification (c-Myc and HER2) and promoter methylation (p14 and p16) in the tumours, tumour margins, and unaffected oral mucosa of 40 OSCC patients, and (2) to evaluate the possibility of using these alterations as prognostic markers. c-Myc and HER2 genes were quantified by means of real-time PCR (qPCR), and p14 and p16 methylation status was determined by methylation-specific PCR (MSP PCR). Read More

    Risk factors for positive margins after wide local excision of cutaneous squamous cell carcinoma.
    J Dermatolog Treat 2018 Feb 16:1-10. Epub 2018 Feb 16.
    b Caringbah medical and dental centre , Caringbah , New South Wales , Australia 2229.
    Background And Objectives: The standard treatment for cutaneous squamous cell carcinoma (cSCC) is wide local excision (WLE). Incomplete tumor excision is associated with increased recurrence rates and mortality risk. Risk factors for positive margins after WLE of cSCC has been examined in only a few studies. Read More

    Spontaneous alveolar bone loss after 4NQO exposure in Wistar rats.
    Arch Oral Biol 2018 Feb 7;89:44-48. Epub 2018 Feb 7.
    Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Rua Ramiro Barcelos, 2492, Porto Alegre, Rio Grande do Sul, Zip code: 90035-003, Brazil. Electronic address:
    Objective: This study evaluated the effect of an experimental carcinogenic, 4-Nitroquinoline 1-oxide (4NQO), in the spontaneous alveolar bone loss (ABL) in an animal model.

    Design: Twenty-two male Wistar rats were included in this study. They were randomly divided into two groups: the control group (n = 10) received food and water ad libitum, and the test group (n = 12) receive the same food; however, 25 ppm of 4NQO was diluted in the drinking water. Read More

    DNA demethylation of claudin-4 suppresses migration and invasion in laryngeal squamous carcinoma cells.
    Hum Pathol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Pathology, the First Bethune Hospital of Jilin University, No. 3302, Jilin Road, Changchun, Jilin 130021, China. Electronic address:
    Claudin-4 (CLDN4) is a member of the claudin transmembrane protein family, which consists of integral membrane proteins that are components of the epithelial cell tight junctions; these tight junctions regulate movement of solutes and ions through the paracellular space. CLDN4 is also a differentiation marker and is believed to indicate an epithelial phenotype. However, the role of CLDN4 in laryngeal squamous carcinoma is still unclear. Read More

    Pediatric head and neck squamous cell carcinoma: Patient demographics, treatment trends and outcomes.
    Int J Pediatr Otorhinolaryngol 2018 Mar 3;106:21-25. Epub 2018 Jan 3.
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI, USA. Electronic address:
    Objectives: To examine patient demographics, temporal and treatment trends, and survival outcomes of pediatric non-nasopharyngeal head and neck squamous cell carcinomas using the National Cancer Database.

    Methods: The National Cancer Database was queried for pediatric patients (age 0-19 years) diagnosed with squamous cell carcinoma of the head and neck (including oral cavity, oropharynx, nasal cavity, larynx, hypopharynx, and salivary glands) from 2004 to 2013.

    Results: Of 159 patients identified, the majority had oral cavity SCC (55%). Read More

    Is it just a psoriasiform dermatitis?
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Department of Dermatology, Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
    Bazex syndrome (BS) is a rare paraneoplastic syndrome most frequently associated with squamous cell carcinomas of the upper aerodigestive tractand other tumours. Characteristically, cutaneous lesions precede the diagnosis of malignancy. We report a 72-year-old patient with 1-year history of acral dermatitis. Read More

    A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas.
    Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer.

    Case Presentation: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses. Read More

    Squamous Cell Carcinoma of the Gingiva Mimicking Periodontal Disease: A Diagnostic Challenge and Therapeutic Dilemma.
    Int J Periodontics Restorative Dent 2018 Mar/Apr;38(2):253-259
    A case of squamous cell carcinoma of the gingiva (GSCC) in the left anterior maxilla in a 64-year-old woman that was treated for almost 5 years as suspected periodontal lesion prior to establishing the final diagnosis of oral cancer is presented in this case report. GSCCs have a variable clinical appearance, ranging from an exophytic mass to ulcerative lesions. They have been reported to pose a diagnostic challenge and are not infrequently initially misdiagnosed as periodontal disease. Read More

    Esophageal squamous cell carcinoma with low mitochondrial copy number has mesenchymal and stem-like characteristics, and contributes to poor prognosis.
    PLoS One 2018 15;13(2):e0193159. Epub 2018 Feb 15.
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
    Alterations in mitochondrial DNA (mtDNA) copy numbers in various human cancers have been studied, but any such changes in esophageal squamous cell carcinoma (ESCC) are not established. In the present study, we investigated the correlation of mtDNA copy number with clinicopathologic features, prognosis, and malignant potential of ESCC. MtDNA copy numbers of resected specimens from 80 patients treated with radical esophagectomy were measured by quantitative real-time PCR analyses. Read More

    The role of human papillomavirus in laryngeal cancer in Southern China.
    J Med Virol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Microbiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
    Objective Delineate the role of human papillomavirus (HPV) in laryngeal cancer in Southern Chinese. Study Design A retrospective cross-sectional study. Setting A major otorhinolaryngology referral center in Hong Kong. Read More

    Corrigendum to "Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma Identified Based on Gene Expression Data and MicroRNA-mRNA Network Analysis".
    Comput Math Methods Med 2017 28;2017:1284606. Epub 2017 Dec 28.
    Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Province Key Laboratory of Stomatology, Guangdong, China.
    [This corrects the article DOI: 10.1155/2017/9803018.]. Read More

    The clinical features of squamous cell lung carcinoma with sensitive EGFR mutations.
    Int J Clin Oncol 2018 Feb 14. Epub 2018 Feb 14.
    Division of Respirology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa, Tokyo, Japan.
    Background: The process of selecting patients on the basis of epidermal growth factor receptor (EGFR) mutations would likely result in a patient population with greater sensitivity to EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, EGFR mutation status is not routinely examined in patients with squamous cell lung cancer (Sq) because of the low incidence of EGFR mutations and the poor clinical response to EGFR-TKIs.

    Methods: We retrospectively reviewed the clinical features of patients at our hospital with Sq who carried EGFR-TKI-sensitive EGFR mutations and assessed their responses to EGFR-TKIs. Read More

    Characteristic findings of high-grade cervical intraepithelial neoplasia or more on magnifying endoscopy with narrow band imaging.
    Int J Clin Oncol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa, 761-0793, Japan.
    Background: Colposcopy, which is a standard modality for diagnosing cervical intraepithelial neoplasia (CIN), can have limited accuracy owing to poor visibility. Flexible magnifying endoscopy with narrow band imaging (ME-NBI) has excellent diagnostic accuracy for early gastrointestinal neoplasms and is expected to be highly useful for CIN diagnosis. This study aimed to determine the characteristic findings and evaluate the diagnostic ability of ME-NBI for lesions ≥ CIN 3. Read More

    Assessing Oral Cancer Awareness Among Dental Students.
    J Cancer Educ 2018 Feb 14. Epub 2018 Feb 14.
    Faculty of Dentistry, Department of Oral Diagnosis and Maxillofacial Radiology, Marmara University, Başıbüyük Sağlık Yerleşkesi Başıbüyük Yolu 9/3 Maltepe, 34854, Istanbul, Turkey.
    The aim of this study was to assess oral cancer awareness among undergraduate dental students in Marmara University Faculty of Dentistry. A validated questionnaire which tested oral cancer awareness was given to third- and fifth-year students of the dental faculty of Marmara University. A total of 198 students participated in this survey. Read More

    Predictors of unexpected nodal upstaging in patients with cT1-3N0 non-small cell lung cancer (NSCLC) submitted to thoracoscopic lobectomy.
    J Vis Surg 2018 17;4:15. Epub 2018 Jan 17.
    Thoracic Surgery Unit, Department of Cardiologic, Thoracic and Vascular Sciences, University Hospital, University of Padova, Padova, Italy.
    Background: In the last decades, the use of video-assisted thoracoscopic surgery (VATS) lobectomy for the treatment of early stage non-small cell lung cancer is continuously growing. This is mainly due to the development of more advanced surgical devices, to the rising incidence of peripheral lung tumors and is also favored by the increased reliability of preoperative staging techniques. Despite this progress, postoperative unexpected nodal upstaging is still a relevant issue. Read More

    Giant genital warts.
    Clin Case Rep 2018 Feb 5;6(2):444-445. Epub 2018 Jan 5.
    2nd Department of SurgerySchool of MedicineAretaieion University HospitalNational and Kapodistrian University of Athens University of Athens76 Vassilisis Sofia's AveAthens11528Greece.
    Genital warts are quite common and should be treated early with nonaggressive conservative or invasive methods. When they are severely neglected patients may be submitted to amputative surgical management. Preoperatively malignant transformation of the tumors cannot be excluded. Read More

    Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study.
    Onco Targets Ther 2018 8;11:743-749. Epub 2018 Feb 8.
    Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, China.
    Objective: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. Read More

    A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma.
    Endocr J 2018 Feb 15. Epub 2018 Feb 15.
    Kusatsu General Hospital, Otolaryngology Head and Neck Thyroid Surgery, Shiga, Japan.
    Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). Read More

    Tracheal replacement.
    Eur Respir J 2018 Feb 14;51(2). Epub 2018 Feb 14.
    Dept of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie-Lannelongue Hospital, Paris-Sud University, Le Plessis Robinson, France.
    Tracheal reconstruction is one of the greatest challenges in thoracic surgery when direct end-to-end anastomosis is impossible or after this procedure has failed. The main indications for tracheal reconstruction include malignant tumours (squamous cell carcinoma, adenoid cystic carcinoma), tracheoesophageal fistula, trauma, unsuccessful surgical results for benign diseases and congenital stenosis. Tracheal substitutes can be classified into five types: 1) synthetic prosthesis; 2) allografts; 3) tracheal transplantation; 4) tissue engineering; and 5) autologous tissue composite. Read More

    Knockdown of long noncoding RNA urothelial cancer-associated 1 enhances cisplatin chemosensitivity in tongue squamous cell carcinoma cells.
    Pharmazie 2016 Oct;71(10):598-602
    Cisplatin-based chemotherapy has been found to improve the prognosis of patients with tongue squamous cell carcinoma (TSCC), the most common oral cancer with a poor prognosis. Chemoresistance to cisplatin appears to be an important clinical problem for cisplatin-based TSCC chemotherapy. Long noncoding RNAs (lncRNAs) play important roles in regulating tumor cells' sensitivity to chemotherapeutic agents. Read More

    Leukemia inhibitory factor produced by fibroblasts within tumor stroma participates in invasion of oral squamous cell carcinoma.
    PLoS One 2018 14;13(2):e0191865. Epub 2018 Feb 14.
    Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    The interaction between cancer cells and the cancer stroma plays a crucial role in tumor progression and metastasis in diverse malignancies, including oral cancer. However, the mechanism underlying this interaction remains incompletely elucidated. Here, to investigate the interaction between oral cancer cells and fibroblasts, which are major cellular components of the tumor stroma, we conducted an in vitro study by using human oral squamous cell carcinoma (OSCC) cell lines and normal human dermal fibroblasts (NHDFs). Read More

    Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment.
    Medicine (Baltimore) 2018 Feb;97(7):e9932
    Department of Gynecology, Cancer Institute Hospital.
    Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known precursor of SCCTO, in patients with ovarian cancer and long-term PLD use.After approval of the institutional review board, medical record of 114 patients who were treated with PLD at our institution between January 2010 and December 2016 were retrospectively reviewed. Read More

    Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis.
    Medicine (Baltimore) 2018 Feb;97(7):e9738
    Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center.
    One of the most common head and neck cancers is laryngeal squamous cell carcinoma (LSCC). LSCC exhibits high mortality rates and has a poor prognosis. The molecular mechanisms leading to the development and progression of LSCC are not entirely clear despite genetic and therapeutic advances and increased survival rates. Read More

    Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2.
    J Dent Res 2018 Feb 1:22034518756071. Epub 2018 Feb 1.
    1 The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.
    High-risk human papillomavirus (HPV) is a major risk factor for oral and pharyngeal cancers (OPCs), yet the detailed mechanisms by which HPV promotes OPCs are not understood. Forkhead box M1B (FoxM1B) is an oncogene essential for cell cycle progression and tumorigenesis, and it is aberrantly overexpressed in many tumors. We previously showed that FoxM1B was the putative target of an epithelial-specific transcription factor, Grainyhead-like 2 (GRHL2). Read More

    Calprotectin and the Initiation and Progression of Head and Neck Cancer.
    J Dent Res 2018 Feb 1:22034518756330. Epub 2018 Feb 1.
    1 Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
    Calprotectin (S100A8/A9), a heterodimeric complex of calcium-binding proteins S100A8 and S100A9, is encoded by genes mapping to the chromosomal locus 1q21.3 of the epidermal differentiation complex. Whereas extracellular calprotectin shows proinflammatory and antimicrobial properties by signaling through RAGE and TLR4, intracytoplasmic S100A8/A9 appears to be important for cellular development, maintenance, and survival. Read More

    Perineural Invasion in Head and Neck Cancer.
    J Dent Res 2018 Feb 1:22034518756297. Epub 2018 Feb 1.
    1 Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
    Perineural invasion (PNI) is a mechanism of tumor dissemination that can provide a challenge to tumor eradication and that is correlated with poor survival. Squamous cell carcinoma, the most common type of head and neck cancer, has a high prevalence of PNI. This review provides an overview of clinical studies on the outcomes and factors associated with PNI in head and neck cancer and on findings on cancer-nerve crosstalk. Read More

    Protein phosphatase 2A (PP2A) inhibitor CIP2A indicates resistance to radiotherapy in rectal cancer.
    Cancer Med 2018 Feb 14. Epub 2018 Feb 14.
    Department of Pathology, University of Turku, Turku, Finland.
    Preoperative (chemo)radiotherapy, (C)RT, is an essential part of the treatment of rectal cancer patients, but tumor response to this therapy among patients is variable. Thus far, there are no clinical biomarkers that could be used to predict response to (C)RT or to stratify patients into different preoperative treatment groups according to their prognosis. Overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) has been demonstrated in several cancers and is frequently associated with reduced survival. Read More

    Epidemiologic associations of HPV-positive oropharyngeal cancer and (pre)cancerous cervical lesions.
    Int J Cancer 2018 Feb 14. Epub 2018 Feb 14.
    Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center/Academic Center for Dentistry Amsterdam (ACTA), Amsterdam.
    Purpose: Human papillomavirus (HPV)- induced oropharyngeal squamous cell carcinoma (OPSCC) is still increasing worldwide. We aimed to investigate if the HPV-prevalence of OPSCC in the Netherlands is rising as well, especially in female patients. In addition, we evaluated the association between HPV-positive OPSCC and suspicious Pap results of the cervix in these female patients. Read More

    Methods for multivariate recurrent event data with measurement error and informative censoring.
    Biometrics 2018 Feb 13. Epub 2018 Feb 13.
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, U.S.A.
    In multivariate recurrent event data regression, observation of recurrent events is usually terminated by other events that are associated with the recurrent event processes, resulting in informative censoring. Additionally, some covariates could be measured with errors. In some applications, an instrumental variable is observed in a subsample, namely a calibration sample, which can be applied for bias correction. Read More

    Immune Checkpoint Blockade: The New Frontier in Cancer Treatment.
    Target Oncol 2018 Feb 13. Epub 2018 Feb 13.
    Division of Medical Oncology, Duke University School of Medicine, Duke Cancer Institute, Duke Box 3198, Durham, NC, 27710, USA.
    Immune checkpoint blockers have revolutionized cancer treatment in recent years. These agents are now approved for the treatment of several malignancies, including melanoma, squamous and non-squamous non-small cell lung cancer, renal cell carcinoma, urothelial carcinoma, and head and neck squamous cell carcinoma. Studies have demonstrated the significant impact of immunotherapy versus standard of care on patient outcomes, including durable response and extended survival. Read More

    Influential factors on radiotherapy efficacy and prognosis in patients with secondary lymph node metastasis after esophagectomy of thoracic esophageal squamous cell carcinoma.
    Cancer Manag Res 2018 2;10:217-225. Epub 2018 Feb 2.
    Department of Radiotherapy and Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, People's Republic of China.
    Background: The purpose of this study was to clarify whether pretreatment tumor burden-related index, including the gross tumor volume (GTV) of metastatic lymph nodes (V) and maximum diameter of metastatic lymph nodes (D), and inflammatory markers, consisting of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), are useful for assessing the therapeutic effects and prognosis with secondary lymph node metastasis (LNM) receiving chemoradiotherapy (CRT) or radiotherapy (RT) alone after resection of esophageal squamous cell carcinoma (ESCC).

    Patients And Methods: A total of 119 patients with secondary LNM after resection of ESCC were recruited and received curative RT only or CRT. The enrolled patients were grouped according to the median values of NLR, PLR, V, and D. Read More

    Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC).
    Sci Rep 2018 Feb 13;8(1):2918. Epub 2018 Feb 13.
    Northwestern University Feinberg School of Medicine, Department of Medicine, Chicago, IL, USA.
    Epithelial-mesenchymal transition (EMT) is able to drive metastasis during progression of multiple cancer types, including non-small cell lung cancer (NSCLC). As resistance to immunotherapy has been associated with EMT and immune exclusion in melanoma, it is important to understand alterations to T-cell infiltration and the tumor microenvironment during EMT in lung adenocarcinoma and squamous cell carcinoma. We conducted an integrated analysis of the immune landscape in NSCLCs through EMT scores derived from a previously established 16 gene signature of canonical EMT markers. Read More

    A correlative analysis of PD-L1, PD-1, PD-L2, EGFR, HER2, and HER3 expression in oropharyngeal squamous cell carcinoma.
    Mol Cancer Ther 2018 Feb 13. Epub 2018 Feb 13.
    Hematology & Oncology, Emory University
    We explored potential associations of the PD-1/PD-L1/PD-L2 pathway with clinical characteristics, outcome, and expression of EGFR, HER2, HER3 in oropharyngeal squamous cell carcinoma (OPSCC) using an institutional database. Protein expression was assessed by immunohistochemistry on tissue microarray sections (EGFR, HER2, HER3) or whole tissue sections (PD-1/PD-L1/PD-L2). Expression of EGFR, HER2, HER3, PD-L1, and PD-L2 was quantified on tumor cells. Read More

    Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy.
    J Craniomaxillofac Surg 2018 Jan 12. Epub 2018 Jan 12.
    Department of Stomatology, (Head of the institution: Professor Yunping Fan), Fifth Affiliated Hospital of Sun Yat-sen University, 52 Meihua East Road, Guangdong, Zhuhai 519000, China. Electronic address:
    Purpose: The aim of this study is to investigate the expression of the autophagy protein p62 in oral squamous cell carcinoma (OSCC) cells before and after chemotherapy. We also detected cancer-associated fibroblasts (CAFs) in these OSCC samples to explore the roles of p62 and CAFs in chemotherapy.

    Materials And Methods: Immunohistochemistry was used to analyze the expression of p62 and α-SMA in 26 paired OSCC samples before and after chemotherapy. Read More

    Detection of HPV16 in Esophageal Cancer in a High-Incidence Region of Malawi.
    Int J Mol Sci 2018 Feb 12;19(2). Epub 2018 Feb 12.
    Department of Gynecology, Jena University Hospital-Friedrich-Schiller-University, 07747 Jena, Germany.
    This study was designed to explore the role of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC). Fifty-five patients receiving diagnostic upper gastrointestinal endoscopy at Zomba Central Hospital or Queen Elizabeth Hospital in Blantyre (Malawi) in 2010, were included in our study. Formalin-fixed paraffin-embedded biopsies were collected for histopathological diagnosis. Read More

    Exploring determinants of care-seeking behaviour of oral cancer patients in India: A qualitative content analysis.
    Cancer Epidemiol 2018 Feb 10;53:141-148. Epub 2018 Feb 10.
    Department of Oral Medicine & Radiology, S.C.B Dental College, Cuttack, India. Electronic address:
    Background: A major public health concern in India is the high morbidity and mortality rates of oral cancer because of late diagnosis. Among the several determinants of this late diagnosis, the most important is the healthcare-seeking behaviour of the oral cancer patients. The aim of this study was to explore the care-seeking behaviour and its determinants among oral cancer patients. Read More

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