156,740 results match your criteria Squamous Cell Carcinoma


Ovarian dermoid cyst complicated by small bowel obstruction, entero-ovarian fistula formation, and malignant degeneration.

Clin Imaging 2019 Mar 8;56:47-51. Epub 2019 Mar 8.

Department of Radiology, Northwell Health System, The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 300 Community Drive, Manhasset, NY 11030, USA. Electronic address:

Dermoid cysts, or mature cystic teratomas, are complicated by malignant degeneration in only 1-2% of cases. Rarely, dermoid cysts result in complications of small bowel obstruction or entero-ovarian fistula formation. In the current report we present the case of a 59-year-old female with a known dermoid cyst who presented with leukocytosis and was discovered to have a small bowel obstruction at the level of an ileo-ovarian fistula. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.03.005DOI Listing

Loss of epidermal hypoxia-inducible factor-1α blocks UVB-induced tumorigenesis by affecting DNA repair capacity and oxidative stress.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Univ. Bordeaux, Inserm, BMGIC, U1035, F-33000 Bordeaux, France; Centre de Référence pour les Maladies Rares de la Peau, CHU de Bordeaux, France. Electronic address:

Hypoxia-inducible factor-1α (HIF-1α) is constitutively expressed in mouse and human epidermis. It plays a crucial role in skin physiology including the response of keratinocytes to ultraviolet (UV) radiation. However, little information is available about its role in photocarcinogenesis. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.035DOI Listing

Intraoperative Depth of Invasion Is Accurate in Early-Stage Oral Cavity Squamous Cell Carcinoma.

J Oral Maxillofac Surg 2019 Feb 20. Epub 2019 Feb 20.

Chair, Section of Oral and Maxillofacial Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.

Purpose: Depth of invasion (DOI) is one predictor of nodal metastasis in oral cavity squamous cell carcinoma (OCSCC) and can facilitate the decision to complete an elective neck dissection (END) in early-stage disease with a clinically negative neck. The purpose of this study was to investigate the accuracy of DOI in intraoperative frozen specimens for T1N0 oral OCSCC.

Materials And Methods: To compare the accuracy of DOI in frozen versus permanent specimens, we completed a prospective, blinded study of 30 patients with cT1N0 OCSCC who presented between October 2016 and December 2017. Read More

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http://dx.doi.org/10.1016/j.joms.2019.02.016DOI Listing
February 2019

Delays in oral cavity cancer.

Int J Oral Maxillofac Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Oral and Maxillofacial Surgery, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

While the prognosis for early-stage oral cavity cancer is relatively good; the majority of patients are still diagnosed with advanced-stage disease on presentation with an associated poorer prognosis. The aims of this review are to summarize our current understanding of delays in oral cavity cancer and their impact on stage at diagnosis and survival. The delays pathway can be subdivided into three components: patient, professional, and treatment delays. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.02.015DOI Listing

[Diagnostic and treatment pitfalls and guidelines for variants of squamous cell carcinomas of the head and neck].

Bull Cancer 2019 Mar 13. Epub 2019 Mar 13.

Hôpital Bichat, département d'oto-rhino-laryngologie (ORL) et chirurgie cervico-faciale, 46 rue Henri-Huchard, 75018 Paris, France.

Among the 20,000 new cases of head and neck neoplasms in France each year, squamous cell carcinomas (HNSCC) represent about 90 % of the cases. Among these, variants of conventional squamous cell carcinomas represent between 5% and 10% of cases. Patient history and risk factors are often similar from those of conventional HSNCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00074551193011
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http://dx.doi.org/10.1016/j.bulcan.2019.01.015DOI Listing
March 2019
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Circulating microRNAs in head and neck cancer: a scoping review of methods.

Clin Exp Metastasis 2019 Mar 14. Epub 2019 Mar 14.

Discipline of Surgery, College of Medicine and Public Health, Flinders University, Bedford Park, Australia.

Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinical validation of candidate biomarkers is lacking. The various methods used to collect, store, process and interpret these microRNAs are likely introducing bias and contributing to the inconsistent results. Read More

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http://dx.doi.org/10.1007/s10585-019-09961-6DOI Listing
March 2019
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3.491 Impact Factor

Prognostic value of advanced lung cancer inflammation index in head and neck squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Purpose: The advanced lung cancer inflammation index (ALI) is a useful tool for prediction of outcome in several malignancies. However, to date, its significance in head and neck cancer patients has not been evaluated.

Methods: We retrospectively analyzed data from 93 patients who were diagnosed with head and neck squamous cell carcinoma (HNSCC) and treated with surgical resection and postoperative radiotherapy between 2002 and 2012. Read More

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http://dx.doi.org/10.1007/s00405-019-05381-0DOI Listing

The use of carbon nanoparticles to track occult lingual lymph nodes in early-stage tongue squamous cell carcinoma.

Int J Oral Maxillofac Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

The lingual lymph nodes (LLNs) can only be detected with difficulty in early-stage tongue squamous cell carcinomas owing to the small size. Recurrence or metastasis could occur in the floor of the mouth as a result of neglecting the LLNs. The injection of carbon nanoparticles to track occult LLNs in early-stage tongue squamous cell carcinoma is presented and discussed. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.02.010DOI Listing

Nuclear protein of the testis midline carcinoma in the oral cavity: retrospective review of those initially diagnosed as poorly differentiated squamous cell carcinoma using an anti-C52B1 antibody.

Int J Oral Maxillofac Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

Nuclear protein of the testis (NUT) midline carcinomas (NMC) are malignant epithelial tumours that have chromosomal rearrangements of the gene encoding NUT at 15q14. NMC is typically an aggressive fatal cancer, clinically overlaps with other carcinomas, and differential diagnosis is difficult. The purpose of this study was to investigate NMC in poorly differentiated oral squamous cell carcinoma (OSCC) with a retrospective analysis based on anti-C52B1 immunohistochemical staining. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.02.012DOI Listing

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma.

EBioMedicine 2019 Mar 12. Epub 2019 Mar 12.

Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address:

Background: Targeting PLK1 has recently been proven as a viable therapeutic strategy against oesophageal squamous cell carcinom (ESCC). Therefore, this study aimed to explore whether the PLK1 inhibitor BI2536 is able to sensitize ESCC cells to cisplatin (DDP) and determine the underlying mechanisms.

Methods: Viability, clonogenicity, cell cycle distribution and apoptosis were assessed in ESCC cells treated with BI2536 or DDP alone or in combination. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.012DOI Listing

Uptake of sentinel lymph node procedures in women with vulvar cancer over time in a population based study.

Gynecol Oncol 2019 Mar 12. Epub 2019 Mar 12.

University of Toronto, Department of Obstetrics and Gynecology, Toronto, Ontario, Canada; Division of Gynecologic Oncology, Odette Cancer Centre, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:

Objectives: To evaluate trends in uptake of sentinel lymph node (SLN) procedures over time and associated factors in women with vulvar cancer.

Methods: A retrospective population-based cohort study identified women with invasive squamous cell carcinoma (SCC) of the vulva using health administrative data for the province of Ontario, Canada, between 2008 and 2016. Patients who underwent SLN procedures were compared to those who had groin node dissection (GND). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193015
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http://dx.doi.org/10.1016/j.ygyno.2019.03.010DOI Listing
March 2019
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Facile fabrication of visible light photoelectrochemical immunosensor for SCCA detection based on BiOBr/BiS heterostructures via self-sacrificial synthesis method.

Talanta 2019 Jun 10;198:417-423. Epub 2019 Feb 10.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.

A novel visible light photoelectrochemical immunosensor based on BiOBr/BiS heterostructures was fabricated to detect squamous cell carcinoma antigen (SCCA). BiS nanoparticles formed on the BiOBr microflowers by the self-sacrificial synthesis method based on the facile reaction between BiOBr and S ions. The BiOBr/BiS composites exhibited excellent visible light photoelectrochemical activity, when ascorbic acid (AA) was employed as a perfect electron donor. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.02.043DOI Listing

Nomogram based on homogeneous and heterogeneous associated factors for predicting bone metastases in patients with different histological types of lung cancer.

BMC Cancer 2019 Mar 15;19(1):238. Epub 2019 Mar 15.

Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tiyuan Bei Road, Hexi District, Tianjin, China.

Background: The purpose of the present study was to characterize the prevalence, associated factors, and to construct a nomogram for predicting bone metastasis (BM) with different histological types of lung cancer.

Patients And Methods: This study was a descriptive study that basing on the invasive lung cancer patients diagnosed between 2010 and 2014 in Surveillance, Epidemiology, and End Results program. A total of 125,652 adult patients were retrieved. Read More

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http://dx.doi.org/10.1186/s12885-019-5445-3DOI Listing

A phase I/II radiation dose escalation trial using simultaneous integrated boost technique with elective nodal irradiation and concurrent chemotherapy for unresectable esophageal Cancer.

Radiat Oncol 2019 Mar 15;14(1):48. Epub 2019 Mar 15.

Department of Radiation Oncology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 Panjiayuan Nanli, Beijing, 100021, China.

Background: To investigate the safety and tolerability of simultaneous integrated boost (SIB) technique concurrent with elective nodal irradiation (ENI) and dual-drug chemotherapy for patients with unresectable esophageal cancer.

Methods: In phase I, the prophylactic PTV received a stable dose of 50.40Gy/1. Read More

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http://dx.doi.org/10.1186/s13014-019-1249-5DOI Listing

Cost differential of immuno-oncology therapy delivered at community versus hospital clinics.

Am J Manag Care 2019 Mar 1;25(3):e66-e70. Epub 2019 Mar 1.

Division of Quality and Informatics, Florida Cancer Specialists & Research Institute, 6420 W Newberry Rd, Ste 100, Gainesville, FL 32605. Email:

Objectives: The site of cancer care delivery has been shown to be associated with the total cost of care. The magnitude of this effect in patients receiving expensive immuno-oncology (I-O) therapies has not been evaluated. We evaluated cost differentials between community-based and hospital-based outpatient clinics among patients receiving I-O therapies. Read More

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Immunotherapy Approaches Beyond PD-1 Inhibition: the Future of Cellular Therapy for Head and Neck Squamous Cell Carcinoma.

Curr Treat Options Oncol 2019 Mar 14;20(4):31. Epub 2019 Mar 14.

Division of Medical Oncology, Department of Medicine, University of Washington, 825 Eastlake Ave East, Mail Stop K2-231, Seattle, WA, 98109, USA.

Opinion Statement: In a span of a few years, the surprising early successes of programmed cell death 1 (PD-1) inhibitors across a vast range of tumor types have transformed our understanding of cancer immunogenicity and provided proof of principle that T cells, if manipulated, can mediate meaningful tumor regression. In head and neck cancer, only a minority of patients respond to PD-1 therapy, but these small outcomes have fueled the enthusiasm for the next generation of immunotherapy-adoptive cell therapy-which employs recent advances in genetic engineering and cell culturing methods to generate T cells with enhanced anti-tumor efficacy for infusion back into the patient. Head and neck cancer is comprised of biologically distinct cancers, HPV-positive and HPV-negative, and the clinical responses to PD-1 inhibitors in both HPV-positive and HPV-negative head and neck patients have showcased better than any other cancer type that there are distinct pathways to immunogenicity that may lend themselves to different therapeutic approaches. Read More

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http://dx.doi.org/10.1007/s11864-019-0630-9DOI Listing

Contemporary Treatment of Locally Advanced Oral Cancer.

Authors:
David Kim Ryan Li

Curr Treat Options Oncol 2019 Mar 14;20(4):32. Epub 2019 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, PV01, Portland, OR, 97239, USA.

Opinion Statement: At our institution, locally advanced oral cancer is most commonly treated with surgical resection, immediate reconstruction, and adjuvant radiotherapy with or without concurrent systemic therapy depending on final surgical pathologic analysis. There are patients with markedly advanced local or regional disease who unfortunately will have a low probability of cure. We counsel these patients on induction chemotherapy, emphasizing that this is unlikely to result in a smaller volume of surgical resection. Read More

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http://dx.doi.org/10.1007/s11864-019-0631-8DOI Listing

Systemic Immunotherapy for Advanced Cutaneous Squamous Cell Carcinoma.

Curr Treat Options Oncol 2019 Mar 14;20(4):30. Epub 2019 Mar 14.

Department of Dermatology, Saitama Medical University, Morohongo 38, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Opinion Statement: Advanced (i.e., unresectable) cutaneous squamous cell carcinoma (cSCC) is a rare condition with a dismal prognosis. Read More

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http://dx.doi.org/10.1007/s11864-019-0629-2DOI Listing
March 2019
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Neurovascular and lymphatic vessels distribution in uterine ligaments based on a 3D reconstruction of histological study: to determine the optimal plane for nerve-sparing radical hysterectomy.

Arch Gynecol Obstet 2019 Mar 14. Epub 2019 Mar 14.

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China.

Objective: To present the distribution of neurovascular and lymphatic vessels in uterine ligaments using 3D models based on the pathological staining of serial 2D sections of postoperative specimens.

Methods: Serial transverse sections of fresh uterine ligaments from a patient with stage IB1 cervical squamous cell carcinoma were studied using the computer-assisted anatomic dissection (CAAD) technique. The sections were stained with hematoxylin and eosin, Weigert elastic fibers, D2-40 and immunostainings (sheep anti-tyrosine hydroxylase and rabbit anti-vasoactive intestinal peptide). Read More

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http://link.springer.com/10.1007/s00404-019-05108-w
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http://dx.doi.org/10.1007/s00404-019-05108-wDOI Listing
March 2019
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PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma.

Oncogene 2019 Mar 15. Epub 2019 Mar 15.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

Advanced and undifferentiated skin squamous cell carcinomas (SCCs) exhibit aggressive growth and enhanced metastasis capability, which is associated in mice with an expansion of the cancer stem-like cell (CSC) population and with changes in the regulatory mechanisms that control the proliferation and invasion of these cells. Indeed, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in advanced SCCs. However, the mechanisms involved in this process were unclear. Read More

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http://dx.doi.org/10.1038/s41388-019-0773-yDOI Listing
March 2019
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Temporal bone carcinoma: Treatment patterns and survival.

Laryngoscope 2019 Mar 15. Epub 2019 Mar 15.

Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa.

Objectives/hypothesis: Carcinomas of the temporal bone are rare, and appropriate treatment, staging, and survival data are limited. This study evaluates clinical characteristics and survival rates for patients with temporal bone carcinoma treated with resection at a single tertiary-care institution, with a focus on the outcomes of patients with locally advanced disease including skull base and/or dural invasion.

Study Design: Retrospective chart review. Read More

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http://dx.doi.org/10.1002/lary.27877DOI Listing

The biological function of long noncoding RNA FAL1 in oesophageal carcinoma cells.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):896-903

a Department of Oncology , Heze municipal hospital , Heze , Shandong , China.

Long non-coding RNAs (lncRNAs) have been reported to be involved in the pathogenesis of a variety of malignancies, including oesophageal cancer. Alterations of the lncRNA focally amplified lncRNA on chromosome 1 (FAL1) are present in epithelial tumours. However, its expression pattern and function in oesophageal cancer are poorly addressed. Read More

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https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1
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http://dx.doi.org/10.1080/21691401.2019.1573738DOI Listing
December 2019
4 Reads

Optimized bexarotene aerosol formulation inhibits major subtypes of lung cancer in mice.

Nano Lett 2019 Mar 15. Epub 2019 Mar 15.

Bexarotene has exhibited inhibitory effects in preclinical models of lung, mammary gland tumorigenesis and in phase I/II trials of non-small cell lung cancer. The major side effects of bexarotene when administered orally were hypertriglyceridemia and hypercholesterolemia. In our previous study we demonstrated that aerosolized bexarotene through nasal inhalation exhibited potent chemopreventive activity in a lung adenoma preclinical model without the hypertriglyceridemia. Read More

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http://dx.doi.org/10.1021/acs.nanolett.8b04309DOI Listing

Soft Tissue Mandibula and Tongue Reconstruction Using A Suprafascial, Folded, Deepithelialized Antero-Lateral Thigh Perforator Free Flap.

World J Plast Surg 2019 Jan;8(1):103-107

Department of Oral- Maxillo-Facial Surgery, Plastic Operations, Dietrich-Bonhoeffer-Klinikum Neubrandenburg, Germany.

Head and neck squamous cell carcinoma (HNSCC) is the most frequent carcinoma of the head and neck region. For coverage of an entire resected mandible with floor of the mouth, 3/4 of the tongue and soft tissue of cheeks and neck bony reconstruction of the mandible and soft tissue reconstruction of tongue, cheeks and a neck large flap are needed. A patient with a superinfected T4 HNSCC was presented to our outpatient clinic. Read More

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http://dx.doi.org/10.29252/wjps.8.1.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409148PMC
January 2019

MiR-106a directly targets LIMK1 to inhibit proliferation and EMT of oral carcinoma cells.

Cell Mol Biol Lett 2019 6;24. Epub 2019 Mar 6.

1Oral and Maxillofacial Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Hebei, 061000 People's Republic of China.

Background: LIM kinase 1 (LIMK1) expression levels are closely associated with microRNA (miRNA) processing. Higher levels of LIMK1 are reported during the progression of many cancers. Our study explored the interaction between LIMK1 and miR-106a in oral squamous cell carcinoma (OSCC). Read More

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https://cmbl.biomedcentral.com/articles/10.1186/s11658-018-0
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http://dx.doi.org/10.1186/s11658-018-0127-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402160PMC
March 2019
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Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer.

Sci Rep 2019 Mar 14;9(1):4520. Epub 2019 Mar 14.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

C6orf141 (Chromosome 6 open reading frame 141) is a novel gene, and its role in oral cancer progression remains unclear. C6orf141 expression in oral squamous cell carcinoma (OSCC) and adjacent normal tissues from 428 patients was examined through immunohistochemistry (IHC). Our results revealed that C6orf141 expression was significantly reduced in OSCC compared with adjacent normal tissues. Read More

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http://dx.doi.org/10.1038/s41598-019-41194-1DOI Listing

Depiction of Oral Tumor-Induced Trigeminal Afferent Responses Using Single-Fiber Electrophysiology.

Sci Rep 2019 Mar 14;9(1):4574. Epub 2019 Mar 14.

Department of Endodontics, University of Texas Health at San Antonio, San Antonio, TX, USA.

Considerable gap in knowledge exists about the mechanisms by which oral tumors regulate peripheral sensory fibers to produce pain and altered sensations. To address this gap, we used a murine model of oral squamous cell carcinoma (OSCC) of the tongue to investigate changes in response properties of trigeminal afferent neurons. Using this model, we developed an ex vivo method for single neuron recordings of the lingual nerve from isolated tongue tissue. Read More

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http://dx.doi.org/10.1038/s41598-019-39824-9DOI Listing

Hepatitis B virus infection is a prognostic biomarker for better survival in operable esophageal cancer: analysis of 2004 patients from an endemic area in China.

Cancer Epidemiol Biomarkers Prev 2019 Mar 14. Epub 2019 Mar 14.

Department of Thoracic Surgery, First Affiliated Hospital of Sun Yat-sen University

Background: Hepatitis B Virus (HBV) infection has been proved to be associated with the survival of many cancers. However, the prevalence and prognostic value of HBV infection in esophageal cancer has not been investigated yet Methods:A total of 2004 consecutive esophageal cancer patients who underwent esophagectomy between 2000 and 2008 were recruited in our study. Enzyme-linked immunosorbent assay was used to test serum HBV markers. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1095DOI Listing

Malignant Transformation of a Filum Terminale Dermoid Tumor into Adenocarcinoma.

World Neurosurg 2019 Mar 11. Epub 2019 Mar 11.

Departments of Neurosurgery.

Background: Intraspinal dermoid tumors are usually rare benign growths that occur as a result of defects during neural tube formation. They make up less than 1% of tumors in the spine and are associated with spinal dysraphisms or sinus tracts. Although rare, malignant transformation into squamous cell carcinoma has been previously reported. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.031DOI Listing

Kamikawa Double-Flap Reconstruction Following Minimally Invasive Ivor-Lewis Esophagectomy.

Ann Thorac Surg 2019 Mar 11. Epub 2019 Mar 11.

Division of General Surgery (Upper Gastrointestinal Surgery), National University Health System, Singapore. Electronic address:

Despite the high incidence of reflux esophagitis, there are few reports of anti-reflux modifications for minimally invasive Ivor-Lewis Esophagectomy. We present a 63 year-old male with mid-thoracic esophageal squamous cell carcinoma who underwent minimally invasive Ivor-Lewis Esophagectomy post neoadjuvant chemoradiotherapy. Laparoscopic dissection, gastric tube creation and mobilization was performed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.077DOI Listing

Drug repositioning in head and neck squamous cell carcinoma: An integrated pathway analysis based on connectivity map and differential gene expression.

Pathol Res Pract 2019 Mar 5. Epub 2019 Mar 5.

Department of Otolaryngology Head and Neck Surgery, NO.303 Hospital of PLA, Nanning, Guangxi Zhuang Autonomous Region, China. Electronic address:

The severe damage to health and social burden caused by head and neck squamous cell carcinoma (HNSCC) generated an urgent need to develop novel anti-cancer therapy. Currently, drug repositioning has risen in responses to the proper time as an efficient approach to invention of new anti-cancer therapies. In the present study, we aimed to screen candidate drugs for HNSCC by integrating HNSCC-related pathways from differentially expressed genes (DEGs) and drug-affected pathways from connectivity map (CMAP). Read More

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http://dx.doi.org/10.1016/j.prp.2019.03.007DOI Listing

Long-Term Exposure to Oroxylin A Inhibits Metastasis by Suppressing CCL2 in Oral Squamous Cell Carcinoma Cells.

Cancers (Basel) 2019 Mar 12;11(3). Epub 2019 Mar 12.

Department of Pharmacology, Tzu Chi University, Hualien 97004, Taiwan.

Oroxylin A (Oro-A), the main bioactive flavonoid extracted from , has been reported to inhibit migration in various human cancer cell models. In this study, we further explored the anti-migration effects of Oro-A on oral squamous cell carcinoma (OSCC) cells and investigated the underlying mechanisms. A 24-h (short-term) exposure of OSCC cells to non-cytotoxic concentrations (5⁻20 μM) of Oro-A significantly suppressed cell migration according to a wound-healing assay. Read More

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http://dx.doi.org/10.3390/cancers11030353DOI Listing

Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient.

Endocrinol Diabetes Metab Case Rep 2019 Mar 14;2019. Epub 2019 Mar 14.

Wolfson Diabetes Centre, Addenbrooke's Hospital Cambridge, Cambridge, UK.

Necrobiosis lipoidica diabeticorum (NLD) is a chronic granulomatous dermatitis generally involving the anterior aspect of the shin, that arises in 0.3-1.2% of patients with diabetes mellitus (1). Read More

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http://dx.doi.org/10.1530/EDM-19-0007DOI Listing
March 2019
2 Reads

Large single cutaneous metastasis of colon adenocarcinoma mimicking a squamous cell carcinoma of the skin: A case report.

Int J Surg Case Rep 2019 Mar 7;56:96-100. Epub 2019 Mar 7.

Multidisciplinary Department of Medical and Dental Specialties, Università degli Studi della Campania "Luigi Vanvitelli", Plastic Surgery Unit, Naples, Italy.

Introduction: Metastases represent one of the most outstanding characteristics of malignant neoplasms and are relatively rare in the skin, in spite of the great extension of the cutaneous organs. Development of cutaneous metastases from colon cancer is a rare event, usually occurring in widely disseminated disease and commonly leading to a poor prognosis. As to location, cutaneous metastases often favor areas close to the primary malignancy, such as lung cancer and skin metastases on the trunk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193010
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http://dx.doi.org/10.1016/j.ijscr.2019.02.043DOI Listing
March 2019
1 Read

For Whom the Bell's Toll: Recurrent Facial Nerve Paralysis, A Retrospective Study and Systematic Review of the Literature.

Otol Neurotol 2019 Apr;40(4):517-528

Department of Otorhinolaryngology.

Purpose: To examine the etiology, clinical course, and management of recurrent peripheral facial nerve paralysis.

Methods: Retrospective review at a single tertiary academic center and systematic review of the literature. Clinical presentation, laboratory and imaging findings, treatment and outcome for all cases of recurrent ipsilateral, recurrent contralateral, and bilateral simultaneous cases of facial paralysis are reviewed. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002167DOI Listing

C188-9, a small-molecule STAT3 inhibitor, exerts an antitumor effect on head and neck squamous cell carcinoma.

Anticancer Drugs 2019 Mar 11. Epub 2019 Mar 11.

Precision Medicine Center, Tianjin Medical University General Hospital, Tianjin, China.

Abnormal activation of signal transducer and activator of transcription 3 (STAT3) is complicated in the tumor progression of multiple cancers including human head and neck squamous cell carcinoma (HNSCC) and, therefore, serves as a potent therapeutic target. In this study, we identify that C188-9, a small-molecule STAT3 inhibitor, exhibits an antitumor effect on HNSCC in vitro. C188-9 significantly inhibits cell growth, arrests cell cycle at G0/G1 phase, and induces apoptosis in HNSCC. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000783DOI Listing

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups.

Inorg Chem 2019 Mar 14. Epub 2019 Mar 14.

The Centre for Molecular Imaging and Translational Research Laboratory , The Peter MacCallum Cancer Centre , Melbourne , Victoria 3000 , Australia.

The synthesis of new bis(thiosemicarbazonato)copper(II) complexes featuring polyamine substituents via selective transamination reactions is presented. Polyamines of different lengths, with different ionizable substituent groups, were used to modify and adjust the hydrophilic/lipophilic balance of the copper complexes. The new analogues were radiolabeled with copper-64 and their lipophilicities estimated using distribution coefficients. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00117DOI Listing

Intratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity.

Head Neck 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.

Background: We sought to evaluate intratumor heterogeneity in squamous cell carcinoma of the oral cavity (OCC) and specifically determine the effect of physical separation and histologic differentiation within the same tumor.

Methods: We performed whole exome sequencing on five biopsy sites-two from well-differentiated, two from poorly differentiated regions, and one from normal parenchyma-from five primary OCC specimens.

Results: We found high levels of intratumor heterogeneity and, in four primary tumors, identified only 0 to 2 identical mutations in all subsites. Read More

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http://dx.doi.org/10.1002/hed.25719DOI Listing

Validation Study of the AJCC Cancer Staging Manual, Eighth Edition, Staging System for Eyelid and Periocular Squamous Cell Carcinoma.

JAMA Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston.

Importance: To our knowledge, there are no validation studies to date of the prognostic value of the AJCC Cancer Staging Manual, eighth edition (AJCC 8), criteria for eyelid and periocular squamous cell carcinoma.

Objective: To determine the association of tumor (T) category in AJCC 8 with local recurrence, nodal metastasis, distant metastasis, and disease-specific survival (DSS) for eyelid and periocular squamous cell carcinoma.

Design, Setting, And Participants: In this retrospective, single-center cohort study, 109 consecutive patients with eyelid and periocular squamous cell carcinoma treated from January 1999 to April 2018 were included. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0238DOI Listing

Association between 18F-FDG uptake in PET/CT, Nrf2, and NQO1 expression and their prognostic significance in non-small cell lung cancer.

Neoplasma 2019 Mar 10;2019. Epub 2019 Mar 10.

Department of Pathology, Ajou University School of Medicine, Ajou University, Suwon, South Korea.

Two pentose phosphate pathway-related proteins, NF-E2-related factor 2 (Nrf2)/ NAD(P)H dehydrogenase (Quinone) 1 (NQO1) regulate the expression of glucose metabolism and antioxidant genes. We evaluated the prognostic significance of NRF2, NQO1 and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) parameter and their relationship with non-small cell lung cancer (NSCLC) histology. A total of 241 patients, who underwent surgical resection for NSCLC, were reviewed retrospectively. Read More

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http://dx.doi.org/10.4149/neo_2018_181007N742DOI Listing

MicroRNA-101 regulates autophagy, proliferation and apoptosis via targeting EZH2 in laryngeal squamous cell carcinoma.

Neoplasma 2019 Mar 7. Epub 2019 Mar 7.

Department of Otolaryngology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

Laryngeal carcinoma is the second commonest head and neck carcinoma globally. MicroRNA-101 (miR-101) has been reported as a tumor suppressor in multiple malignancies including laryngeal squamous cell carcinoma (LSCC). However, the roles and molecular mechanisms of miR-101 in the development of LSCC have not been fully elucidated. Read More

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http://dx.doi.org/10.4149/neo_2018_180811N611DOI Listing

Prostate Cancer Metastasis To Cervical Node Chain-An Unusual Clinic-Pathological Finding.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):134-135

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Prostate carcinoma is one of the most common cancers in males all around the world. Head and neck squamous cell carcinoma is amongst the leading carcinoma (HNSCC) in men especially in the sub-continent. There are around 150 lymph nodes on either side in the neck and cervical lymph nodes are a common site for head and neck malignancies to metastasize however carcinoma of prostate may in rare cases metastasize to cervical chain, therefore warranting a neck dissection. Read More

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Socio-Economic Implications Of A Younger Aged Female Predilection In Malignant Transformation Of Oral Sub Mucous Fibrosis.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):16-20

Ziauddin College of Dentistry, Ziauddin University, Karachi, Pakistan.

Background: This study was conducted to determine the age, gender and pattern of associated chewing habits among cases of oral squamous cell carcinoma (OSCC) presenting with, (OSMFCa) and without, (Ca-OSMF) pre-existing clinical oral submucous fibrosis in Karachi, Pakistan.

Methods: A cross sectional, multi centric study of (n=1009) cases with histologically confirmed oral squamous cell carcinoma seen at both public, private tertiary care hospitals and clinics over a period of eight years. A non-probability convenience sampling was used for selection of cases. Read More

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Overexpression of S100A4 Predicts Migration, Invasion, and Poor Prognosis of Hypopharyngeal Squamous Cell Carcinoma.

Mol Diagn Ther 2019 Mar 13. Epub 2019 Mar 13.

NHC Key Laboratory of Otorhinolaryngology, Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.

Introduction: Hypopharyngeal squamous cell carcinoma (HSCC) is among the most lethal tumors encountered in the head and neck and frequently involves regional metastasis. However, the mechanism underlying the aggressiveness of HSCC remains elusive. S100A4 is a well-established metastasis-promoting regulator in a variety of malignancies, but its role in HSCC has not yet been identified. Read More

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http://dx.doi.org/10.1007/s40291-019-00393-2DOI Listing

Omitting Elective Irradiation of the Contralateral Retropharyngeal Nodes in Oropharyngeal Squamous Cell Carcinoma Treated with Intensity-modulated Radiotherapy.

Cureus 2019 Jan 4;11(1):e3825. Epub 2019 Jan 4.

Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, USA.

Introduction: The use of intensity-modulated radiation therapy (IMRT) in head and neck cancers has allowed for selective sparing of low-risk or uninvolved lymph nodes. In oropharyngeal cancers, the benefits and risks of omitting contralateral retropharyngeal lymph nodes (RPLN) remain uncertain. This study examines the outcomes of elective coverage of contralateral RPLN in oropharyngeal cancer treated with definitive IMRT. Read More

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http://dx.doi.org/10.7759/cureus.3825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402860PMC
January 2019

Tooth and Advanced Oral Submucous Fibrosis Obscuring Buccal Squamous Cell Carcinoma: A Case Report and Literature Review.

Cureus 2018 Dec 31;10(12):e3802. Epub 2018 Dec 31.

Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Chennai, IND.

Oral squamous cell carcinoma is a leading cause of mortality due to late diagnosis in India and most other developing countries. Buccal squamous cell carcinoma is almost always preceded by premalignant conditions that include leukoplakia, erythroplakia, oral lichen planus, and submucous fibrosis of the oral cavity. Hence, these patients warrant regular screening by oral health care professionals and proper monitoring for any dysplastic changes. Read More

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http://dx.doi.org/10.7759/cureus.3802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402749PMC
December 2018

IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization.

Comput Struct Biotechnol J 2019 7;17:251-262. Epub 2019 Feb 7.

Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)/CIBERONC, Madrid 28040, Spain.

Lung cancer is the leading worldwide cause of cancer mortality, however, neither curative treatments nor substantial prolonged survival has been achieved, highlighting the need for investigating new proteins responsible for its development and progression. IKKα is an essential protein for cell survival and differentiation, which expression is enhanced in human non-small cell lung cancer (NSCLC) and correlates with poor patient survival, appearing as a relevant molecule in lung cancer progression. However, there are not conclusive results about its role in this type of cancer. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396199PMC
February 2019
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Serum miR-626 and miR-5100 are Promising Prognosis Predictors for Oral Squamous Cell Carcinoma.

Theranostics 2019 25;9(4):920-931. Epub 2019 Jan 25.

Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology.

Although serum microRNAs (miRNAs) are currently being considered as promising noninvasive biomarkers for cancers, their role in the prognosis of oral squamous cell carcinoma (OSCC) has not been elucidated. Here we aimed to identify serum miRNA biomarkers that could be used as prognosis predictors of OSCC. : A cohort of 260 serum miRNA samples was assessed in a three-step approach that included a screening stage, a training stage, and a testing stage. Read More

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http://dx.doi.org/10.7150/thno.30339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401397PMC
January 2019
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Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma.

Oncol Lett 2019 Mar 1;17(3):3548-3554. Epub 2019 Feb 1.

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.

The associations between human papillomavirus (HPV) infection or hormonal exposure and cervical cancer risk are well established. However, to the best of our knowledge, the association between high endogenous estradiol levels in conjunction with HPV/HPV16 infection and the risk of cervical squamous cell carcinoma remains unknown. To investigate this, the current study conducted a matched case-control study in Shanxi Province, China, in which clinical samples were obtained from 74 females with newly diagnosed uterine cervix squamous cell carcinoma and 74 matched healthy females who were selected from 582 healthy females according to age, place of residence, marital status and menopausal status. Read More

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http://dx.doi.org/10.3892/ol.2019.10005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396129PMC

Long non-coding RNA CRNDE regulates cell proliferation, migration, invasion, epithelial-mesenchymal transition and apoptosis in oral squamous cell carcinoma.

Oncol Lett 2019 Mar 28;17(3):3330-3340. Epub 2019 Jan 28.

Department of Stomatology, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, P.R. China.

The present study aimed to investigate whether the long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) can promote the migration and invasion of human oral squamous cell carcinoma (OSCC) cells via the regulation of epithelial-mesenchymal transition (EMT). CAL-27 and SCC-15 cells were classified into a control group, a small interfering negative control (si-NC) group (cells transfected with control siRNA) and an si-CRNDE group (cells transfected with CRNDE siRNA). The expression of CRNDE in OSCC tissues and cell lines was detected by hybridization (ISH) and reverse transcription-quantitative polymerase chain reaction. Read More

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http://dx.doi.org/10.3892/ol.2019.9978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396137PMC