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    141519 results match your criteria Squamous Cell Carcinoma

    1 OF 2831

    CXCR4: A New Player in an Old Scene?
    ORL J Otorhinolaryngol Relat Spec 2017 Feb 24;79(1-2):34-42. Epub 2017 Feb 24.
    Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, Munich, Germany.
    Transmembrane C-X-C chemokine receptor 4 (CXCR4) and its ligand C-X-C motif chemokine 12 (CXCL12) came into focus in many solid cancers, allowing a more fundamental diagnostic and therapeutic approach by modulating the immune response against cancer cells. CXCR4 and CXCL12 mediate cell proliferation, migration, and metastatic outgrowth in head and neck squamous cell carcinoma (HNSCC) and are strongly associated with cancer recurrence and patient survival. Despite recent advances in molecular imaging and cancer therapy in lymphoma using CXCL12 analogues, clinical trials evaluating the diagnostic and therapeutic impact on HNSCC are missing. Read More

    Checkpoint Inhibition in Head and Neck Cancer: Immune Therapeutic Options, Limitations, and Beyond.
    ORL J Otorhinolaryngol Relat Spec 2017 Feb 24;79(1-2):24-33. Epub 2017 Feb 24.
    Institute of Molecular Immunology and Experimental Oncology, Klinikum München rechts der Isar, Technische Universität München, Munich, Germany.
    The immune system functions to defend the organism against infectious microorganisms but also against transformed cells. This key role of the immune system, in particular cancer-specific T cells, in eliminating cancer cells is compromised by various immune escape strategies employed by cancer cells and the cancer microenvironment. Here, we review the current knowledge about the immune escape mechanisms of cancer and the attempts to reconstitute cancer-specific immunity by using checkpoint inhibitors in head and neck squamous cell carcinoma. Read More

    Radiomics in Head and Neck Cancer: Extracting Valuable Information from Data beyond Recognition.
    ORL J Otorhinolaryngol Relat Spec 2017 Feb 24;79(1-2):65-71. Epub 2017 Feb 24.
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Düsseldorf, Düsseldorf, Germany.
    In oncology, biomarkers that describe the characteristics of a malignancy on different levels (clinical, histological, molecular) and the patient's outcome and treatment response are increasingly integrated into the clinical routine. Extensive screening tools, "omics," offer incredible opportunities and vast amounts of data. During the last years, the field of "omics" gained a new promising partner, the "radiomics. Read More

    Response Evaluation in Head and Neck Oncology: Definition and Prediction.
    ORL J Otorhinolaryngol Relat Spec 2017 Feb 24;79(1-2):14-23. Epub 2017 Feb 24.
    Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.
    Curative treatment of head and neck squamous cell carcinoma includes surgery and/or (chemo)radiation, whereas in the palliative setting, chemotherapy and/or immunotherapy represent(s) the standard approach. With regard to quality control, methods for determining treatment response are sorely needed. For surgical therapy, histopathology is the standard quality control. Read More

    Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma.
    Head Neck 2017 Feb 23. Epub 2017 Feb 23.
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: Mutations in the human telomerase reverse transcriptase (TERT) promoter contribute to increased TERT activity. The purpose of the present study was to assess the prevalence of TERT promoter mutations in oral cavity squamous cell carcinoma (SCC).

    Methods: Total DNA was extracted from 201 oral cavity SCC tumors and adjacent normal tissues. Read More

    Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients.
    J Cancer Res Ther 2016 Dec;12(Supplement):C288-C290
    Department of Thyroid and Breast Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China.
    Objective: The purpose of this meta-analysis was to evaluate the association between cyclooxygenase-2 (Cox-2) expression and skin cancer.

    Materials And Methods: We searched the databases of PubMed, CNKI, and WANFANG to find the case-control studies associated with Cox-2 expression and skin cancer. The association between Cox-2 expression and skin cancer was demonstrated by odds ratio (OR) and its 95% confidence interval (95% CI). Read More

    Application of colon interposition among the esophageal cancer patients with partial gastrectomy.
    J Cancer Res Ther 2016 Dec;12(Supplement):C212-C216
    Department of Thoracic Surgery, Zhejiang Hospital, Hangzhou, Zhejiang, China.
    Background: Esophageal reconstruction with colon interposition is an alternative solution for the esophageal cancer patients who have partial gastrectomy. The aim of this study was to investigate the therapeutic effects of colon interposition among the esophageal carcinoma patients with partial gastrectomy.

    Materials And Methods: Under institutional review board approval, 32 esophageal carcinoma patients with a history of partial gastrectomy were included in this study. Read More

    Assessment of cetuximab-induced infusion reactions and administration rechallenge at an academic medical center.
    Med Oncol 2017 Apr 22;34(4):51. Epub 2017 Feb 22.
    University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
    Cetuximab is approved for treatment of squamous cell carcinoma of the head and neck (SCCHN). Cetuximab is generally well tolerated, but does carry a black box warning for infusion reactions (IRs). Incidence of IR in clinical trials was 15-20% for all grades and 3-5% for grades III-IV. Read More

    History, molecular features, and clinical importance of conventional serum biomarkers in lung cancer.
    Surg Today 2017 Feb 22. Epub 2017 Feb 22.
    Department of Translational Medicine Informatics, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
    Serum biomarkers provide valuable information about the diagnosis and prognosis of a wide variety of malignant tumors. Despite the identification of several useful serum biomarkers in lung cancer, consensus on their utility has not yet been reached. Furthermore, guidelines and standard protocols to implement their use for patients with lung cancer are lacking, despite the accumulation of much data on the efficacy of several serum biomarkers over recent decades. Read More

    Overexpression of suppressor of zest 12 is associated with cervical node metastasis and unfavorable prognosis in tongue squamous cell carcinoma.
    Cancer Cell Int 2017 13;17:26. Epub 2017 Feb 13.
    0000 0000 9255 8984grid.89957.3aJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029 People's Republic of China ; 0000 0000 9255 8984grid.89957.3aDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, 136, Hanzhong Road, Nanjing, 210029 People's Republic of China.
    Objective: Increased expression of suppressor of zest 12 (SUZ12), a core component of the polycomb repressive complex 2, contributes to human tumorigenesis and associates with patient prognosis. In the present study, we sought to investigate the expression of SUZ12 and its clinicopathological significance in primary tongue squamous cell carcinoma (TSCC).

    Methods: The expression of SUZ12 protein was determined by immunohistochemistry in clinical samples from a retrospective cohort of 72 patients with primary TSCC who were treated at our institution from Jan. Read More

    High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma.
    Onco Targets Ther 2017 9;10:617-625. Epub 2017 Feb 9.
    Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin, People's Republic of China.
    Background: Glucose-regulated protein 78 (GRP78) plays an important role in the invasion and metastasis of many human cancers. However, the role of this protein in the progression of invasion and metastasis in esophageal squamous cell carcinoma (ESCC) remains elusive.

    Patients And Methods: Immunohistochemistry and Western blot were performed to analyze GRP78 expression in 92 patients with primary ESCC. Read More

    Tumor Associated Tissue Eosinophilia in Oral Squamous Cell Carcinoma: A Histo-Chemical Analysis.
    Malays J Med Sci 2015 Nov;22(6):21-25
    Department of Oral Pathology, Narsinbhai Patel Dental College and Hospital Visnagar, Mahesana, Gujarat 384315, India.
    Background: Tumor associated tissue eosinophilia (TATE) is believed to play a significant role in biological behavior of the carcinoma. Eosinophils are involved in immune reaction. Various studies have been carried out regarding their role in tumor progression or regulation. Read More

    [Analysis of clinicopathological characteristics and prognosis on 42 patients with primary gastric adenosquamous cell carcinoma].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Feb;20(2):207-212
    Department of Gastric Cancer Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
    Objective: To investigate the clinicopathological characteristics, diagnosis, treatment and prognosis of patients with primary gastric adenosquamous cell carcinoma.

    Methods: A total of 5 562 patients with gastric neoplasm were admitted in Tianjin Medical University Cancer Institute and Hospital from January 2001 to January 2011. Among them 42 patients were diagnosed as primary gastric adenosquamous cell carcinoma, accounting for 0. Read More

    Penile squamous cell carcinoma: a review of the literature and case report treated with Mohs micrographic surgery.
    An Bras Dermatol 2017 Jan-Feb;92(1):95-99
    Department of Dermatology - State University of New York - Downstate and Veterans Affairs Medical Center - Brooklyn (NY), United States.
    The majority of penile carcinoma is squamous cell carcinoma. Although uncommon in the United States, it represents a larger proportion of cancers in the underdeveloped world. Invasive squamous cell carcinoma may arise from precursor lesions or de novo , and has been associated with lack of circumcision and HPV infection. Read More

    Analysis of the histomorphologic profile of invasive cutaneous squamous cell carcinoma from 2002 to 2011 in a pathology laboratory in the region of Campos Gerais, Brazil.
    An Bras Dermatol 2017 Jan-Feb;92(1):81-85
    Departament of Medicine - Universidade Estadual de Ponta Grossa (UEPG) - Ponta Grossa (PR), Brazil.
    Squamous cell carcinoma is the second most common type of malignant skin cancer. It is also quite aggressive. The increasing incidence of the disease can be altered given its connection with sun exposure. Read More

    Non-melanoma skin cancer and risk of Alzheimer's disease and all-cause dementia.
    PLoS One 2017 22;12(2):e0171527. Epub 2017 Feb 22.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Cancer patients may be at decreased risk of Alzheimer's disease. This hypothesis is best developed for non-melanoma skin cancer (NMSC), but supportive epidemiological data are sparse. We therefore conducted a nationwide cohort study of the association between NMSC and Alzheimer's disease (main outcome) and all-cause dementia. Read More

    Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma.
    PLoS One 2017 22;12(2):e0171116. Epub 2017 Feb 22.
    Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Objective: We investigated the association between B-cell lymphoma/leukaemia 11A (BCL11A) rs11886868 and rs4671393 polymorphism, plasma BCL11A concentration, and the hazard of developing laryngeal squamous cell carcinoma (LSCC).

    Participants And Method: In this research, 330 LSCC patients, 310 healthy controls, and 155 vocal leukoplakia patients were genotyped for the BCL11A (rs11886868 C/T and rs4671393 A/G) genotypes by pyrosequencing; the BCL11A concentration was measured using ELISA.

    Results: LSCC Patients had a notably higher occurrence of CT at rs11886868 (OR = 2. Read More

    Global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: Focus on low-risk areas.
    Int J Cancer 2017 Feb 22. Epub 2017 Feb 22.
    Department of Clinical Sciences and Community Health, Universitá degli Studi di Milano, 20133, Milan, Italy.
    Nasopharyngeal cancer (NPC) mortality shows great disparity between endemic high risk areas, where non-keratinizing carcinoma (NKC) histology is prevalent, and non-endemic low risk regions, where the keratinizing squamous cell carcinoma (KSCC) type is more frequent. We used the World Health Organization database to calculate NPC mortality trends from 1970 to 2014 in several countries worldwide. For the EU, the USA and Japan, we also predicted trends to 2020. Read More

    How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?
    Adv Ther 2017 Feb 21. Epub 2017 Feb 21.
    Coordinator of the International Head and Neck Scientific Group, Padua, Italy.
    Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. Read More

    Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors.
    Support Care Cancer 2017 Feb 22. Epub 2017 Feb 22.
    Oral Medicine Department, Institut Claudius Regaud, Institut Universitaire du cancer Toulouse-Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex, France.
    Development of biological targeted therapies and immune checkpoint inhibitors has redefined the treatment for many cancers; however, the increasing use of new protocols has led to physicians observing a new spectrum of toxicities. To date, oral adverse events induced by these new anticancer therapies have been mainly reported using nonspecific terminology ("stomatitis," "mucosal inflammation," "mucositis") and remain poorly characterized, with the exception of mammalian target of rapamycin (mTOR) inhibitor-associated stomatitis. Oral toxicities of targeted therapies often display very characteristic features which clearly differ from classic oral injuries observed with cytotoxic chemotherapy and/or radiotherapy. Read More

    RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium.
    Genom Data 2017 Jun 5;12:4-6. Epub 2017 Feb 5.
    Laboratory of Biological Macromolecules, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan.
    Esophageal cancer (EC) is the eighth most common cancer globally in 2012 and predominantly occurs in the man (Enzinger and Mayer, 2003; Conteduca et al., 2012). EC is classified mainly into two types, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma, accounting for 60-70% and 20-30% of all EC cases, respectively. Read More

    Ingenol Mebutate Topical Gel A Status Report On Clinical Use Beyond Actinic Keratosis.
    J Clin Aesthet Dermatol 2016 Nov;9(11 Suppl 1):S3-S11
    Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, Nevada; Research Director, Del Rosso Dermatology Research Center, Las Vegas, Nevada.
    Ingenol mebutate is available as a topical gel formulation approved for the treatment of actinic keratosis. Two different concentrations are available for treatment of actinic keratoses at specific anatomic sites with the advantages of short durations of therapy and limited "down time" related to visible inflammation as compared to other topical agents. Due to the various modes of action of ingenol mebutate, it has also been used for treatment of disease states other than actinic keratosis. Read More

    Bile salt receptor TGR5 is highly expressed in esophageal adenocarcinoma and precancerous lesions with significantly worse overall survival and gender differences.
    Clin Exp Gastroenterol 2017 7;10:29-37. Epub 2017 Feb 7.
    Department of Pathology and Laboratory Medicine.
    Bile acid reflux in the esophagus plays an important role in the carcinogenesis of esophageal adenocarcinoma (EAC). The G-protein coupled bile acid receptor (TGR5) has been associated with the development of gastrointestinal cancer. However, little is known regarding the role of TGR5 in esophageal carcinoma and precancerous lesions. Read More

    miR182 activates the Ras-MEK-ERK pathway in human oral cavity squamous cell carcinoma by suppressing RASA1 and SPRED1.
    Onco Targets Ther 2017 7;10:667-679. Epub 2017 Feb 7.
    Department of Osteological Surgery, Harbin First Hospital, Harbin, People's Republic of China.
    Purpose: The constitutive activation of the Ras-MEK-ERK signaling pathway in oral cavity squamous cell carcinoma (OSCC) has been found to be tightly controlled at multiple levels under physiological conditions. RASA1 and SPRED1 are two important negative regulators of this pathway, but the exact regulating mechanism remains unclear. In this study, we aimed to explore the potential regulating mechanisms involved in the Ras-MEK-ERK signaling pathway in OSCC. Read More

    Is endoscopic ultrasound examination necessary in the management of esophageal cancer?
    World J Gastroenterol 2017 Feb;23(5):751-762
    Tomas DaVee, Jeffrey H Lee, Department of Gastroenterology, Hepatology and Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
    Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer (EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970s, the result of advances in diagnostic staging and treatment. Read More

    Prognostic alternative mRNA splicing signature in non-small cell lung cancer.
    Cancer Lett 2017 Feb 18. Epub 2017 Feb 18.
    Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:
    Alternative splicing provides a major mechanism to generate protein diversity. Increasing evidence suggests a link of dysregulation of splicing associated with cancer. Genome-wide alternative splicing profiling in lung cancer remains largely unstudied. Read More

    Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
    Lancet Oncol 2017 Feb 17. Epub 2017 Feb 17.
    The University of Texas-MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
    Background: Squamous cell carcinoma of the anal canal (SCCA) is a rare malignancy associated with infection by human papillomavirus (HPV). No consensus treatment approach exists for the treatment of metastatic disease. Because intratumoral HPV oncoproteins upregulate immune checkpoint proteins such as PD-1 to evade immune-mediated cytotoxicity, we did a trial of the anti-PD-1 antibody nivolumab for patients with metastatic SCCA. Read More

    The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma.
    J Otolaryngol Head Neck Surg 2017 Feb 22;46(1):15. Epub 2017 Feb 22.
    Division of Otolaryngology, Department of Surgery, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada.
    Background: HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. Deregulation of the Hippo pathway induces an abnormal cellular transformation, epithelial to mesenchymal transition, which promotes oncogenic progression. Read More

    FOXF2 promoter methylation is associated with prognosis in esophageal squamous cell carcinoma.
    Tumour Biol 2017 Feb;39(2):1010428317692230
    1 Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.
    Esophageal squamous cell carcinoma is a commonly malignant tumor of digestive tract with poor prognosis. Previous studies suggested that forkhead box F2 ( FOXF2) could be a candidate gene for assessing and predicting the prognosis of human cancers. However, the relationship between FOXF2 promoter methylation and the prognosis of esophageal squamous cell carcinoma remained unclear. Read More

    A novel tumor pretargeting system based on complementary L-configured oligonucleotides.
    Bioconjug Chem 2017 Feb 22. Epub 2017 Feb 22.
    Unnatural mirror image L-configured oligonucleotides (L-ONs) are a convenient substance class for the application as complementary in vivo recognition system between a tumor specific antibody and a smaller radiolabeled effector molecule in pretargeting approaches. The high hybridization velocity and defined melting conditions are excellent preconditions of the L-ON based methodology. Their high metabolic stability and negligible unspecific binding to endogenous targets are superior characteristics in comparison to their D-configured analogs. Read More

    Squamous cell carcinoma presenting as an orbital cyst with radiologic evidence of perineural invasion.
    Eur J Ophthalmol 2007 Nov-Dec;17:970-972
    Oculoplastic and Orbital Division, Department of Ophthalmology and Visual Sciences, University of Ad.
    Purpose: To report clinical and radiologic findings of cystic squamous cell carcinoma (SCC) of the orbit with evidence of perineural involvement.

    Methods: Analysis of clinical findings and radiology with a literature review.

    Results: A 66-year-old man with SCC of the forehead 8 years prior presented with paraesthesias, diplopia, and proptosis. Read More

    Impact of PD-L1 Expression in Patients with Surgically Resected Non-Small-Cell Lung Cancer.
    Oncology 2017 Feb 22. Epub 2017 Feb 22.
    Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara-city, Japan.
    Background: Immunotherapy can become a crucial therapeutic option to improve the prognosis of patients with non-small-cell lung cancer (NSCLC). Here, we evaluated the impact of programmed cell death ligand-1 (PD-L1) expression in surgically resected NSCLCs.

    Methods: We estimated PD-L1 expression in 229 consecutive NSCLC specimens using rabbit polyclonal antibodies to human PD-L1 in a SP263 immunohistochemical assay and evaluated PD-L1 expression for potential associations with clinicopathological parameters and survival time. Read More

    Multikinase inhibitors sorafenib and sunitinib as radiosensitizers in head and neck cancer cell lines.
    Head Neck 2017 Feb 21. Epub 2017 Feb 21.
    Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
    Background: Radioresistance is a common feature of head and neck squamous cell carcinoma (HNSCC). We previously showed that the irradiation- activated vascular endothelial growth factor (VEGF)-extracellular signal-regulated kinase (ERK)-axis is fundamental for the survival of resistant tumors. In this study, we examined if treatment with potent multikinase (MK) inhibitors, sorafenib and sunitinib, could radiosensitize tumor cells. Read More

    Thermal Burn Scar-Related Squamous Cell Carcinoma in the Eyelid.
    Ophthal Plast Reconstr Surg 2017 Feb 17. Epub 2017 Feb 17.
    *Ophthalmology Department, Uludag University and †Bursa Pathology Center, Bursa, Turkey.
    A 63-year-old woman presented with a large, ulcerokeratotic mass in her right lower eyelid that had grown over the last 2 months in a burn scar. She had experienced a thermal burn involving both inferior periorbital areas 35 years ago and received medical treatment. The lesion was excised with wide margins. Read More

    Retin Cases Brief Rep 2017 Feb 17. Epub 2017 Feb 17.
    Departments of *Ophthalmology, and †Nuclear Medicine, Uludag University School of Medicine, Bursa, Turkey.
    Background/purpose: To present a case with retinal metastasis from squamous cell carcinoma of the lung.

    Methods: Case report.

    Results: A 54-year-old man presented with blurry vision in his left eye. Read More

    Prognostic Value of Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma: a Meta-analysis.
    Sci Rep 2017 Feb 21;7:43008. Epub 2017 Feb 21.
    Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China.
    Bmi-1, CD133, Nanog and Oct-4 have been reported as cancer stem cell (CSC) markers in head and neck squamous cell carcinoma (HNSCC). However, the prognostic value of them in HNSCC remains controversial. Hence, this meta-analysis was conducted to access the association between the four CSC markers and survival outcome of HNSCC patients. Read More

    The influence of HIV infection on the age dependence of squamous cell carcinoma of the skin in South Africa.
    S Afr Med J 2017 Jan 30;107(2):127-129. Epub 2017 Jan 30.
    Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
    Background: Cancer incidence typically increases with age, but it is not known whether ethnic characteristics influence the age dependence of squamous cell carcinoma of the skin (SCC).

    Objectives: (i) To determine the age dependence of SCC in the black African, coloured and white population groups of South Africa (SA); and (ii) to show whether any differences in the rate of change of age dependence could be influenced by diversity in behaviour and lifestyle, especially with regard to the prevalence of HIV infection, rather than by a fundamental variation in cancer biology between the populations.

    Methods: Linear regression analysis was applied to the logarithm of the age-specific incidence rates for SCC v. Read More

    Aberrant expression of CDK8 regulates the malignant phenotype and associated with poor prognosis in human laryngeal squamous cell carcinoma.
    Eur Arch Otorhinolaryngol 2017 Feb 20. Epub 2017 Feb 20.
    Services of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 148, Bao jian Road, Harbin, 150081, People's Republic of China.
    CDK8, a member of the transcriptional subtype of the cyclin-dependent kinases (CDKs) family, shows remarkable cancer tissue specific expression profile and rather more selective contribution to the regulation of gene expression levels involved in some signaling pathways. However, the effect of CDK8 on the malignant phenotype of human laryngeal squamous cell carcinoma (LSCC) cells and the potential molecular mechanisms remain unclear. In the present study, we evaluated the expression levels of CDK8 by quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry in tissue samples of 60 LSCC patients. Read More

    Primary squamous cell carcinoma of the thyroid. Initial assessment and follow-up using (18)F-FDG PET/CT.
    Rev Esp Med Nucl Imagen Mol 2017 Feb 16. Epub 2017 Feb 16.
    Servicio de Medicina Nuclear, Hospital Virgen del Rocío, Sevilla, España.
    Squamous cell carcinoma of thyroid is an uncommon, very aggressive neoplasm, having a poor prognosis and poor response to chemotherapy and radiotherapy. Surgery is the initial treatment of choice, although it often presents as a widespread disease at the time of diagnosis, usually with cervical swelling that causes most of the symptoms due to local infiltration or metastasis. Local infiltration from adjacent tumour and metastatic disease needs to be excluded from other primary epidermoid carcinomas, in order to make a correct diagnosis. Read More

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones.
    Elife 2017 Feb 21;6. Epub 2017 Feb 21.
    Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
    Squamous cell carcinomas occurring at transition zones are highly malignant tumors with poor prognosis. The identity of the cell population and the signaling pathways involved in the progression of transition zone squamous cell carcinoma are poorly understood, hence representing limited options for targeted therapies. Here, we identify a highly tumorigenic cancer stem cell population in a mouse model of transitional epithelial carcinoma and uncover a novel mechanism by which loss of TGFβ receptor II (Tgfbr2) mediates invasion and metastasis through de-repression of ELMO1, a RAC-activating guanine exchange factor, specifically in cancer stem cells of transition zone tumors. Read More

    [Precision medical treatment of non-adenocarcinoma NSCLC patients with EGFR mutation].
    Zhonghua Zhong Liu Za Zhi 2017 Feb;39(2):90-93
    Department of Oncology, Shandong Cancer Hospital, Jinan 250117, China.
    EGFR tyrosine kinase inhibitors (TKIs) treatment has been established as standard therapy for EGFR-mutated adenocarcinomas. In the studies which published prospective randomized trials comparing EGFR TKIs with chemotherapy, a very low percentage of EGFR-mutated non-adenocarcinomas was enrolled in clinical trials. The efficacy of TKIs treatment for EGFR-mutated non-adenocarcinomas and their relationship with clinicopathological characteristics remain debatable. Read More

    [Enrichment and detection of circulating tumor cells and its application in head and neck squamous cell carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;52(2):147-151
    Otorhinolaryngology and Head and Neck Surgery Department, Nanjing Tongren Hospital, school of Medicine, Southeast University, Nanjing 211100, China.
    Circulating tumor cells are tumor cells from the primary tumor or metastatic tumor to fall off into the circulatory system. They are closely related to the recurrence and metastasis of tumor. Detection of circulating tumor cells as a "liquid biopsy" , to get the tumor information through non-invasive sampling method. Read More

    [Immunotherapy for head and neck squamous cell carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;52(2):143-147
    Department of Otorhinolaryngology Head and Neck Surgery, Eye Ear Nose Throat Hospital of Fndan University, Shanghai 200031, China.
    Head and neck squamous cell carcinoma(HNSCC) is the sixth most common malignancies of human beings. The prognosis of advanced HNSCC is poor despite improvements in traditional treatment strategies including surgery, chemotherapy, and radiotherapy. Cancer immunotherapy is the use of the immune system to treat cancer, which provides a sustained antitumor reaction but an absense of chemoresistance. Read More

    Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men.
    Cancer Sci 2017 Feb 20. Epub 2017 Feb 20.
    Department of Health Promotion, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, 351-0104, Japan.
    Soft palatal melanosis can be detected by visual inspection during routine physical examination or even personally in a mirror. The aim of this study was to evaluate the association between squamous cell neoplasia in the upper aerodigestive tract (UAT) and the soft palatal melanosis. We reviewed digitalized records of high-quality endoscopic images of the soft palate of 1786 Japanese alcoholic men who underwent endoscopic screening. Read More

    FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?
    Int J Mol Sci 2017 Feb 18;18(2). Epub 2017 Feb 18.
    Department of Advanced Biomedical Sciences, University "Federico II", 80131 Naples, Italy.
    Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better stratify OSCC patients' risk to address targeted therapeutic strategies. The role of immune response in the pathogenesis and biological behavior of OSCC has been investigated by several authors, and promising results have been obtained with immune checkpoint inhibitors. Read More

    Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review.
    Clin Exp Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    BMJ Technology Assessment Group, BMJ, London, UK.
    Background: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy.

    Aim: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Read More

    Risk of Non-melanoma Skin Cancer in Patients with Atopic Dermatitis Treated with Oral Immunosuppressive Drugs.
    Acta Derm Venereol 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
    There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the Netherlands, were analysed. NMSC after oral immunosuppressive treatment was reported in 18 patients (3. Read More

    Right ventricular metastatic tumor from a primary carcinoma of uterine cervix: A cause of pulmonary embolism.
    Obstet Gynecol Sci 2017 Jan 15;60(1):129-132. Epub 2017 Jan 15.
    Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
    The presence of intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix is extremely rare. The diagnosis is made almost exclusively postmortem. Apart from causing intracardiac obstruction, it can present as pulmonary emboli and the prognosis is extremely poor. Read More

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