167,624 results match your criteria Squamous Cell Carcinoma


Radiomic analysis identifies tumor subtypes associated with distinct molecular and microenvironmental factors in head and neck squamous cell carcinoma.

Oral Oncol 2020 Jun 30;110:104877. Epub 2020 Jun 30.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

Purpose: To identify whether radiomic features from pre-treatment computed tomography (CT) scans can predict molecular differences between head and neck squamous cell carcinoma (HNSCC) using The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA).

Methods: 77 patients from the TCIA with HNSCC had imaging suitable for analysis. Radiomic features were extracted and unsupervised consensus clustering was performed to identify subtypes. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104877DOI Listing

Definitive chemoradiotherapy plus cetuximab for cancer in the oesophagus or gastro-oesophageal junction.

Cancer Treat Res Commun 2020 Jun 27;24:100187. Epub 2020 Jun 27.

Department of Oncology, Rigshospitalet, Copenhagen, Denmark.

Background: Chemoradiotherapy is standard treatment for localized oesophageal cancer unsuitable for surgery. We aimed to evaluate the efficacy of cetuximab in combination with chemoradiotherapy.

Methods: This non-randomised multicentre phase II trial recruited patients aged 18-75 with WHO performance status 0-2 having squamous cell carcinoma or adenocarcinoma in the oesophagus or gastro-oesophageal junction, T2-4, N0-3, M0 not suitable for surgery. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100187DOI Listing

Iron chelation promotes 5-aminolaevulinic acid-based photodynamic therapy against oral tongue squamous cell carcinoma.

Photodiagnosis Photodyn Ther 2020 Jun 30:101907. Epub 2020 Jun 30.

School of Dentistry & Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Background: Oral tongue squamous cell carcinoma (OTSCC) is the most common malignancy of the oral cavity. Photodynamic therapy (PDT) has become a clinically promising approach for OTSCC treatment. 5-Aminolaevulinic acid (5-ALA) is a precursor of protoporphyrin IX (PpIX) and has been applied for PDT of cancer. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101907DOI Listing

Impact of compliance to chemoradiation on long-term outcomes in squamous cell carcinoma of the anus. Results of a post-hoc analysis from the randomized phase III ACT II trial.

Ann Oncol 2020 Jun 30. Epub 2020 Jun 30.

School of Medicine, Cardiff University, Cardiff, UK.

Purpose: Concurrent chemoradiation is standard-of-care for patients with squamous cell carcinoma of the anus (SCCA). Poor compliance to chemotherapy, radiotherapy treatment interruptions and unplanned breaks may impact adversely on long-term outcomes.

Methods: The ACT II trial recruited 940 patients with localized SCCA, and assigned patients to mitomycin (week 1) or cisplatin (weeks 1 and 5), with fluorouracil (weeks 1 & 5) and radiotherapy (50·4Gy in 28 fractions over 38 days). Read More

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http://dx.doi.org/10.1016/j.annonc.2020.06.012DOI Listing

TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.

Gastroenterology 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA; Cancer Science Institute of Singapore, National University of Singapore, Singapore; National University Cancer Institute, National University Hospital Singapore, Singapore.

Background & Aims: We investigated the transcriptome of esophageal squamous cell carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and the effects of blocking epigenetic regulatory proteins.

Methods: We performed chromatin immunoprecipitation sequencing with antibodies against H3K4me1, H3K4me3, and H3K27ac and an assay for transposase accessible chromatin to map the enhancer regions and accessible chromatin in 8 ESCC cell lines. We used the CRC_Mapper algorithm to identify core regulatory circuitry transcription factors in ESCC cell lines, and determined genome occupancy profiles for 3 of these factors. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.06.050DOI Listing

Prevalence of Synchronous ESCN in Head and Neck Cancer: A Single-Institution Perspective.

Laryngoscope 2020 Jul 3. Epub 2020 Jul 3.

Department of Otolaryngology, Head and Neck Surgery, All India Institute of Medical Sciences New Delhi, Delhi, India.

Objectives: The primary objective was to determine the prevalence of synchronous esophageal squamous cell carcinoma in head and neck squamous cell carcinoma (HNSCC) patients. The secondary objective was to determine risk factors for the development of synchronous esophageal squamous cell carcinoma (ESCN).

Study Design: Cross sectional observation study. Read More

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http://dx.doi.org/10.1002/lary.28821DOI Listing

Conditional Survival after Surgery for Patients with Penile Cancer.

Andrology 2020 Jul 3. Epub 2020 Jul 3.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Penile cancer represents a rare pathology whose natural history of treatment is poorly understood.

Objective: To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates.

Materials And Methods: Patients with non-metastatic SCCP were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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http://dx.doi.org/10.1111/andr.12856DOI Listing

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.

J Pathol 2020 Jul 3. Epub 2020 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, US.

Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the esophagus, oral cavity, bladder, and lung. Between 10 and 35% of patients with squamous cell carcinomas display hyperactive NRF2 signaling, harboring activating mutations and copy number amplifications of the NFE2L2 oncogene or inactivating mutations or deletions of KEAP1 or CUL3, the proteins of which co-complex to ubiquitylate and degrade NRF2 protein. Read More

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http://dx.doi.org/10.1002/path.5504DOI Listing

Trends in pediatric skin cancer.

Curr Opin Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence.

Recent Findings: The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000917DOI Listing

Esophageal Histological Precursor Lesions and Subsequent 8.5-Year Cancer Risk in a Population-Based Prospective Study in China.

Am J Gastroenterol 2020 Jul;115(7):1036-1044

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Data on the associations between esophageal histological lesions and risk of esophageal squamous cell carcinoma (ESCC) in general populations are limited. We aimed to investigate these associations in a large Chinese general population to inform future Chinese ESCC screening guidelines.

Methods: We performed endoscopic screening of 21,111 participants aged 40-69 years from 3 high-risk areas of China in 2005-2009, and followed the cohort through 2016. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000640DOI Listing

Detection of human papillomavirus distinguishes second primary tumors from lung metastases in patients with squamous cell carcinoma of the cervix.

Thorac Cancer 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: In patients with squamous cell carcinoma of the cervix (SCCC), a squamous cell carcinoma (SqCC) in the lung represents either a second primary tumor or metastasis. This distinction between second primary tumors and lung metastases in patients with SCCC significantly influences patient prognosis and therapy. Here, we aimed to differentiate second primary tumors from lung metastases in patients with SCCC by exploring the HPV status in SqCCs involving the lung within a large cohort. Read More

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http://dx.doi.org/10.1111/1759-7714.13544DOI Listing

Trends in parotidectomy over 30 years in an Australian tertiary care center.

Head Neck 2020 Jul 3. Epub 2020 Jul 3.

Head and Neck Oncology, Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Background: Nomenclature, classification, and management of parotid tumors are constantly evolving; this study was performed to identify temporal trends in histology and facial nerve sacrifice in parotidectomy during a 30-year period (1987-2018).

Methods: Retrospective analysis of patients treated in a single tertiary-care institution during this time period was performed with analysis of temporal trends.

Results: Two thousand eight hundred and fifty-seven parotidectomies were performed; pleomorphic adenoma was the most common histology (34. Read More

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http://dx.doi.org/10.1002/hed.26335DOI Listing

Access to preventive care services and stage at diagnosis in head and neck cancer.

Head Neck 2020 Jul 3. Epub 2020 Jul 3.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: Decreased access to preventive care services has been proposed as a mechanism for the association between low socioeconomic status (SES) and advanced stage at diagnosis in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: Retrospective analysis of patients diagnosed with HNSCC in North Carolina between 2002 and 2006.

Results: A total of 1108 patients with HNSCC were included in the study. Read More

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http://dx.doi.org/10.1002/hed.26326DOI Listing

Eyelid skin trichilemmoma and underlying local malignancy: is an aggressive treatment necessary?

BMJ Open Ophthalmol 2020 25;5(1):e000513. Epub 2020 Jun 25.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

Objective: Trichilemmoma is a benign tumour derived from the outer root sheath of hair follicles. Trichilemmoma can be associated with basal cell carcinoma (BCC), either as a collision lesion or from malignant transformation. This study evaluates malignancy associated with eyelid trichilemmoma and principles of treatment. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319780PMC

Does a history of head and neck cancer affect outcome of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma?

Endosc Int Open 2020 Jul 16;8(7):E900-E910. Epub 2020 Jun 16.

Department of Gastroenterology, Cancer Institute, Hospital das Clinicas of University of Sao Paulo, Sao Paulo, Brazil.

Esophageal squamous cell carcinoma (ESCC) is the most common secondary tumor in patients with head and neck squamous cell cancer (HNSCC). Currently, endoscopic submucosal dissection (ESD) is the preferred approach to manage superficial ESCC, however, it remains to be elucidated whether patients with HNSCC and early ESCC managed by ESD have different outcomes. We retrospectively analyzed esophageal ESD for early ESCC from September 2009 to September 2017 and the following variables: demographics, tumor and specimen size, Paris classification, location, en bloc and R0 resection rates, overall survival (OS) and adverse events (AEs). Read More

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http://dx.doi.org/10.1055/a-1147-8977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297610PMC

Downregulation of long non-coding RNA LINP1 inhibits the malignant progression of esophageal squamous cell carcinoma.

Ann Transl Med 2020 Jun;8(11):675

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Long noncoding RNA (lncRNA) in non-homologous end joining pathway 1 (LINP1) contributes to tumorigenesis in various cancers. However, little has been known about the role of LINP1 in esophageal squamous cell carcinoma (ESCC).

Methods: LINP1 was selected as the target lncRNA by bioinformatics analysis. Read More

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http://dx.doi.org/10.21037/atm-20-1009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327344PMC

Whole genome sequencing analysis identifies recurrent structural alterations in esophageal squamous cell carcinoma.

PeerJ 2020 26;8:e9294. Epub 2020 Jun 26.

Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Esophageal squamous cell carcinoma (ESCC) is the predominant type of esophageal cancer in the Asian region, including Japan. A previous study reported mutational landscape of Japanese ESCCs by using exome sequencing. However, somatic structural alterations were yet to be explored. Read More

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http://dx.doi.org/10.7717/peerj.9294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323713PMC

ACTL6A suppresses p21 expression to enhance the epidermal squamous cell carcinoma phenotype.

Oncogene 2020 Jul 2. Epub 2020 Jul 2.

Department of Biochemistry and Molecular Biology, Baltimore, MD, USA.

Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated with increased expression of pro-cancer genes and reduced expression of cancer suppressors. Actin-Like Protein 6A (ACTL6A, BAF53a) is an important protein subunit of the SWI/SNF epigenetic chromatin regulatory complex. Read More

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http://dx.doi.org/10.1038/s41388-020-1371-8DOI Listing

The utility of postoperative radiotherapy in intermediate-risk oral squamous cell carcinoma.

Int J Oral Maxillofac Surg 2020 Jun 29. Epub 2020 Jun 29.

Faculty of Medicine, University of Queensland, Herston, Queensland, Australia; Radiation Oncology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

The effectiveness of postoperative radiotherapy (PORT) in improving outcomes remains debatable for oral squamous cell carcinoma (OSCC) patients with pathological intermediate-risk factors (IRFs) after surgery. A retrospective analysis was conducted on 432 intermediate-risk OSCC patients defined by histological reporting of close margin (<5mm), early nodal disease (pN1), depth of invasion/tumour thickness ≥5mm, perineural invasion, and/or lymphovascular invasion. Outcomes measured were disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS). Read More

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http://dx.doi.org/10.1016/j.ijom.2020.06.006DOI Listing

TRG-AS1 is a potent driver of oncogenicity of tongue squamous cell carcinoma through microRNA-543/Yes-associated protein 1 axis regulation.

Cell Cycle 2020 Jul 2:1-14. Epub 2020 Jul 2.

Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University , Zhengzhou, Henan, P.R. China.

The long noncoding RNA T cell receptor gamma locus antisense RNA 1 (TRG-AS1) plays an important role in glioblastoma progression. The objective of this study was to determine the expression status of TRG-AS1 in tongue squamous cell carcinoma (TSCC). The regulatory effects of TRG-AS1 depletion on the malignant processes of TSCC cells were illustrated both and . Read More

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http://dx.doi.org/10.1080/15384101.2020.1786622DOI Listing

Salvage surgery in head and neck cancer: External validation of predictors of disease-specific survival.

Oral Oncol 2020 Jun 29;109:104876. Epub 2020 Jun 29.

Department of Otolaryngology-Head and Neck Surgery, University Hospital de la Santa Creu i Sant Pau, Universitat Autonòma de Barcelona, Barcelona, Spain.

Objective: Salvage surgery in recurrent head and neck squamous cell carcinoma (HNSCC) is associated with poor outcomes. There is great interest to better identify suitable surgical patients. This study aimed to validate the proposal of Hamoir et al. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104876DOI Listing

Treatment implications of postoperative chemoradiotherapy for squamous cell carcinoma of the oral cavity with minor and major extranodal extension.

Oral Oncol 2020 Jun 29;110:104845. Epub 2020 Jun 29.

Department of Pathology, University Health Network, Toronto, Canada.

Objectives: To evaluate adjuvant chemoradiotherapy (CRT) for patients with oral cavity squamous cell carcinoma (OSCC) with minor or major extranodal extension (ENE).

Materials And Methods: Surgically resected OSCC with pathologically involved lymph node(s) (pN+) between 2006 and 2017. Sections of pN+ were re-reviewed and classified as no, minor (≤2 mm), or major (>2 mm) ENE. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104845DOI Listing

Comparative transcriptomic profiling in HPV-associated cervical carcinogenesis: Implication of MHC class II and immunoglobulin heavy chain genes.

Life Sci 2020 Jun 29:118026. Epub 2020 Jun 29.

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia. Electronic address:

Aim: We aimed to determine the biological processes and pathways involved in cervical carcinogenesis associated with high-risk human papillomavirus (HPV) infection.

Materials And Methods: Total RNA was extracted from three formalin-fixed paraffin-embedded (FFPE) samples each of normal cervix, HPV-infected low-grade squamous intraepithelial lesion (LSIL), high-grade SIL (HSIL) and squamous cell carcinoma (SCC). Transcriptomic profiling by microarrays was conducted followed by downstream Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118026DOI Listing

Polygenic risk scores allow risk stratification for keratinocyte cancer in organ transplant recipients.

J Invest Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove QLD 4059, Australia.

Organ transplant recipients (OTRs) have an elevated risk for keratinocyte cancers (KC); basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We assessed whether polygenic risk scores (PRSs) generated in non-transplantees from the UK Biobank and 23andMe (13,981 SCC, 33,736 BCC, and >560,000 controls), can predict KC risk in an independent OTR cohort. After adjusting for traditional risk factors, compared to the bottom 20%, OTRs in the top 20% PRS had an increased risk of BCC (OR = 3. Read More

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http://dx.doi.org/10.1016/j.jid.2020.06.017DOI Listing

Downregulation of Per2 Promotes Tumor Progression by Enhancing Glycolysis via the PI3K/AKT Pathway in Oral Squamous Cell Carcinoma.

J Oral Maxillofac Surg 2020 Jun 1. Epub 2020 Jun 1.

Professor, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Purpose: Per2 gene expression is downregulated in oral squamous cell carcinoma (OSCC) and may have a pivotal role in tumor suppression. However, the biological function and mechanism of action of Per2 in OSCC remain unclear. In this study, the biological functions and anticancer mechanisms of Per2 in OSCC were investigated. Read More

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http://dx.doi.org/10.1016/j.joms.2020.05.035DOI Listing

Diagnosis and Treatment of Metastatic Disease to the Pancreas.

J Laparoendosc Adv Surg Tech A 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery, Mount Sinai Medical Center, Comprehensive Cancer Center, Miami Beach, Florida, USA.

Metastatic disease to the pancreas is a rare entity from all malignant pancreatic masses. Its diagnosis is very challenging, but with the introduction of endoscopic ultrasound (EUS)-fine needle aspiration (FNA), now there is a feasible way to make an accurate histopathological and definitive diagnosis. This is a retrospective review of 11 patients with metastasis to the pancreas diagnosed with EUS-FNA in a tertiary referral center over a period of 3 years. Read More

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http://dx.doi.org/10.1089/lap.2020.0219DOI Listing

Downregulation of miR-125b-5p and Its Prospective Molecular Mechanism in Lung Squamous Cell Carcinoma.

Cancer Biother Radiopharm 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.

To explore the clinical significance of miR-125b-5p and its potential mechanisms in lung squamous cell carcinoma (LUSC). An integrated analysis of data from in-house quantitative real-time polymerase chain reaction (qRT-PCR), microRNA-sequencing, and microarray assays to appraise the expression level of miR-125b-5p in LUSC tissues compared to adjacent noncancerous controls. The authors identified the candidate targets of miR-125b-5p and conducted functional analysis using computational biology strategies from gene ontology, the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, disease ontology (DO), and protein-protein interaction (PPI) network analyses to investigate the prospective mechanisms. Read More

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http://dx.doi.org/10.1089/cbr.2020.3657DOI Listing

Simultaneous response of cutaneous and lung squamous cell carcinoma with cemiplimab.

Dermatol Ther 2020 Jul 2:e13951. Epub 2020 Jul 2.

Department of Dermatology - Centre Hospitalier Universitaire de Nancy, Nancy, France.

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http://dx.doi.org/10.1111/dth.13951DOI Listing

Correlation Between Immunoinflammatory Measures and Periostin Expression in Esophageal Squamous Cell Carcinoma: A Single-Center, Retrospective Cohort Study.

Ann Surg Oncol 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.

Background: Immunoinflammatory measures such as the neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), and the C-reactive protein (CRP)-albumin ratio (CAR) are useful prognostic measures in various malignancies. However, no study has investigated the correlation of these measures with microenvironmental inflammation. Periostin (POSTN), a small extracellular matrix protein, strongly associates with cancer microenvironmental inflammation. Read More

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http://dx.doi.org/10.1245/s10434-020-08765-3DOI Listing

The usefulness of the IMAP propeller flap for trachea and tracheostome reconstruction after resection of parastomal recurrence of squamous cell carcinoma following salvage total laryngectomy.

Eur Arch Otorhinolaryngol 2020 Jul 1. Epub 2020 Jul 1.

Institute of Plastic Reconstructive and Aesthetic Surgery, A. Gemelli University Hospital Foundation IRCCS, Catholic University of the Sacred Heart, Rome, Italy.

Purpose: Parastomal recurrence of squamous cell carcinoma (SCC) with tracheal involvement following salvage total laryngectomy after prior concurrent chemoradiotherapy is one of the most insidious challenges in head and neck surgery because a complex reconstruction is often required for covering a large area of skin loss, filling the dead space beneath, tracheal reconstruction and suspension, and tracheostome resurfacing. The aim is to describe our experience with the internal mammary artery perforator (IMAP) propeller flap for tracheal and tracheostome reconstruction and neck resurfacing after parastomal and cervical trachea resection, especially for suspension and anchoring the stump of the residual distal trachea to the island flap itself.

Methods: We describe IMAP flap reconstruction after resection of parastomal recurrence of SCC requiring cervical trachea resection in five patients between January 1, 2005 and August 30, 2019. Read More

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http://dx.doi.org/10.1007/s00405-020-06168-4DOI Listing

Efficacy of enhanced prehabilitation for patients with esophageal cancer undergoing esophagectomy.

Esophagus 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate, 028-3695, Japan.

Background: Several studies have demonstrated that prehabilitation helps reduce the incidence of postoperative complications. In this study, we investigated the safety and efficacy of enhanced prehabilitation (EP) in the hospital for patients with esophageal cancer.

Methods: We retrospectively reviewed the data of 48 consecutive patients who underwent radical esophagectomy with gastric tube reconstruction between September 2015 and June 2019. Read More

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http://dx.doi.org/10.1007/s10388-020-00757-2DOI Listing

[Prognostic and predictive methylation biomarkers in HNSCC : Epigenomic diagnostics for head and neck squamous cell carcinoma (HNSCC)].

HNO 2020 Jul 1. Epub 2020 Jul 1.

Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.

Background: Prognostic and predictive biomarkers for personalized treatment management in head and neck squamous cell carcinoma (HNSCC) are of great clinical interest.

Objective: DNA methylation is an epigenetic process involved in gene regulation and could be a source of potential prognostic and predictive biomarkers.

Methods: This study comprises literature research in PubMed and own studies. Read More

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http://dx.doi.org/10.1007/s00106-020-00902-4DOI Listing

A rare case of squamous inclusion cyst in cervical lymph node.

Heliyon 2020 Jun 24;6(6):e04225. Epub 2020 Jun 24.

Pathology Department, Abderrahmen Mami Hospital, Ariana, Tunisia.

A 38-year-old man, with no history of malignancy, was found to have a 2 cm jugular lymph node, for which a lymph node tuberculosis was suspected. The specimen revealed a cystic structure lined by mature keratinizing squamous epithelium with a prominent granular cell layer consistent with a squamous inclusion cyst in a lymph node, but a metastatic squamous cell carcinoma could not be excluded. This is the first case report of a rapidly enlarging squamous inclusion cyst in a jugular lymph node. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322126PMC

Squamous cell carcinoma of the scalp causing cortical venous thrombosis and Intraparenchymal hematoma.

eNeurologicalSci 2020 Sep 18;20:100251. Epub 2020 Jun 18.

Department of Neurosurgery, University of California San Diego. La Jolla, CA, USA.

•We present a case of squamous cell carcinoma causing cortical venous thrombosis (CoVT)•This is the first case of an invasive scalp lesion causing CoVT and brain hemorrhage•Some cases of CoVT may be managed conservatively•Recurrent, invasive squamous cell carcinoma remains therapeutically challenging. Read More

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http://dx.doi.org/10.1016/j.ensci.2020.100251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317240PMC
September 2020

Proteomic and Phosphoproteomic Maps of Lung Squamous Cell Carcinoma From Chinese Patients.

Front Oncol 2020 16;10:963. Epub 2020 Jun 16.

Chemical Proteomics Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Lung squamous cell carcinoma (LUSC) is one of the leading causes of tumor-driven deaths in the world. To date, studies on the tumor heterogeneity of LUSC at genomic level have only revealed limited therapeutic benefits. Therefore, system-wide research of LUSC at proteomic level may further improve precision medicine strategies on individual demands. Read More

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http://dx.doi.org/10.3389/fonc.2020.00963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308564PMC

The expression of Cathepsin L in oral lichen planus.

J Oral Biol Craniofac Res 2020 Jul-Sep;10(3):281-286. Epub 2020 Jun 16.

Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand.

Background: Malignant transformation of oral lichen planus (OLP) was reported particularly in erosive type, however, it remains inconclusive. Cathepsin L was shown to promote tumor growth and invasion in many cancers. Therefore, cathepsin L expression in erosive and non-erosive OLP compared with oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) were investigated. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322187PMC

Periorbital, conjunctival and primary intraorbital carcinomas: Survival and risk factors after orbital exenteration.

Eye (Lond) 2020 Jul 1. Epub 2020 Jul 1.

Department of Oral and Maxillofacial Surgery, University of Duisburg-Essen, Kliniken-Essen-Mitte, Henricistr. 92, 45136, Essen, Germany.

Objectives: This study aimed to analyse the disease-free survival (DFS), overall survival (OS) and risk factors after orbital exenteration in patients with periorbital, conjunctival and primary intraorbital carcinomas.

Methods: Patients undergoing orbital exenteration due to a primary carcinoma between March 2000 and March 2018 were included in this retrospective study. Risk factors in all the patients were evaluated using univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1038/s41433-020-1055-1DOI Listing

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.

Expert Rev Mol Med 2020 Jul 2;22:e3. Epub 2020 Jul 2.

Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 200 London Road, LiverpoolL3 9TA, UK.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with reported incidences of ~800 000 cases each year. One of the critical determinants in patient response to radiotherapy, particularly for oropharyngeal cancers, is human papillomavirus (HPV) status where HPV-positive patients display improved survival rates and outcomes particularly because of increased responsiveness to radiotherapy. The increased radiosensitivity of HPV-positive HNSCC has been largely linked with defects in the signalling and repair of DNA double-strand breaks. Read More

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http://dx.doi.org/10.1017/erm.2020.4DOI Listing

Esophagectomy versus definitive chemoradiotherapy for patients with clinical stage N0 and pathological stage T1b esophageal squamous cell carcinoma after endoscopic submucosal dissection: study protocol for a multicenter randomized controlled trial (Ad-ESD Trial).

Trials 2020 Jul 1;21(1):603. Epub 2020 Jul 1.

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, No.241 West Huaihai Road, Shanghai, 200030, China.

Background: Esophagectomy is still advised as an additional treatment for pathological T1b (pT1b) esophageal squamous cell carcinoma (ESCC) following attempted endoscopic resection (ER). ER followed with definitive chemoradiotherapy (dCRT) has shown increased quality of life as well as comparable oncological outcomes to esophagectomy. However, there is no well-designed phase III trial to compare the two treatments for patients with pT1b ESCC. Read More

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http://dx.doi.org/10.1186/s13063-020-04461-5DOI Listing

Poorer prognosis of ovarian squamous cell carcinoma than serous carcinoma: a propensity score matching analysis based on the SEER database.

Authors:
Cheng Zhang Tai Ma

J Ovarian Res 2020 Jul 1;13(1):75. Epub 2020 Jul 1.

Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: Ovarian squamous cell carcinoma (SCC) is a rare cancer with possible poor survival, however no direct evidence supports this viewpoint and the independent prognostic factors are controversial. Patients with ovarian SCC and serous carcinoma (SC) who were diagnosed between 2004 and 2016 were selected using the recent released SEER database. Propensity score matching was used to balance the characteristics of the two groups. Read More

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http://dx.doi.org/10.1186/s13048-020-00675-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329546PMC

Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by or .

Future Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of General, Visceral & Cancer Surgery, University of Cologne, Kerpner Str. 62, Cologne, 50924, Germany.

To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. The distribution of the genotypes of rs16115 and C3435T rs1045642 was significantly different between both patients' groups. Read More

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http://dx.doi.org/10.2217/fon-2020-0489DOI Listing

Quantitative assessment of CD15 positive tissue eosinophils in Oral Squamous Cell Carcinoma: effects on mast cells and tumor angiogenesis.

Minerva Stomatol 2020 Jun;69(3):133-140

Department of Oral and Maxillofacial Pathology and Oral Microbiology, I.T.S Center for Dental Studies and Research, Muradnagar, India.

Background: The present study determines to correlate eosinophil, mast cell and microvessel densities with the histopathological grades and clinical staging of Oral Squamous Cell Carcinoma (OSCC) cases, as the potential role of inflammatory mediators within tumor stroma remains debatable.

Methods: The study sample comprised 60 cases consisting of 40 cases of Well to moderately differentiated OSCC (group 1) and 20 cases of poorly differentiated OSCC (group 2). Immunohistochemistry with anti-CD15 antibody and antifactor VIII antibody; and toluidine blue special stain were employed for the detection of eosinophils, microvessels, and mast cells, respectively. Read More

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http://dx.doi.org/10.23736/S0026-4970.19.04285-7DOI Listing

Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts.

Cancers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Oral cavity squamous cell carcinomas (OSCCs) are aggressive tumors, and their recurrence leads to poor prognosis and reduced survival rates. This study aimed to identify therapeutic targets and to evaluate the efficacy of targeted inhibitors in OSCC patient-derived xenograft (PDX) models. Herein, we reported that OSCC PDXs recapitulated the genomic signatures of their paired primary tumors and the expression of , , and was significantly upregulated in OSCC. Read More

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http://dx.doi.org/10.3390/cancers12071726DOI Listing

[The expression of p53 protein and its clinicopathological features and prognosis of esophageal spindle cell carcinoma].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):715-720

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To evaluate the association of p53 protein expression with clinicopathological features and prognosis in esophageal spindle cell carcinoma. A total of 4 439 esophageal squamous cell carcinoma (ESCC) patients who underwent radical esophagectomy without neoadjuvant therapy between May 2010 and May 2019 were included. The HE slides and clinicopathological parameters were reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20200106-00014DOI Listing

Which Larynx-Preservation Strategy Would Be Best for a Patient With Resectable, Locally Advanced, Hypopharynx Squamous Cell Carcinoma?

Oncology (Williston Park) 2020 Jun;34(6):211-215

LP strategies should be considered only in patients with resectable stage III/IV larynx and hypopharynx SCC, ideally those who have a functional larynx. The choice of treatment must be discussed by a multidisciplinary team, and the patient must have an active role in making the decision. CRT and IC-RT are both approved larynx-preservation approaches. Read More

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Patient-Reported GI Outcomes in Patients With Anal Cancer Receiving Modern Chemoradiation.

JCO Oncol Pract 2020 Jul 1:OP2000122. Epub 2020 Jul 1.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Among patients with anal cancer, chemoradiotherapy is often associated with toxicities that diminish quality of life. We describe the GI-related patient-reported outcomes (PROs) of patients with anal cancer receiving chemoradiotherapy to improve patient-physician communication.

Methods: We prospectively followed patients with nonmetastatic squamous cell carcinoma of the anal canal who received definitive chemoradiotherapy. Read More

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http://dx.doi.org/10.1200/OP.20.00122DOI Listing

Successful non-operative treatment of eruptive keratoacanthomas refractory to excision.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Division of Dermatology, University of Kansas Medical Center, Kansas City, KS.

Keratoacanthomas are rapidly growing neoplasms of squamous epithelium. Despite their benign nature, they are often difficult to distinguish from squamous cell carcinoma and require excision. In cases in which excision is not successful or not desired, intralesional treatments may be considered. Read More

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Squamous cell carcinoma of the dorsal hands and feet after repeated exposure to ultraviolet nail lamps.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

University of Utah School of Medicine, Salt Lake City, UT, USA.

Gel nails are a common artificial nail option. Ultraviolet (UV) nail lamps are commonly used to cure gel nails. Ultraviolet A radiation is a known mutagen that penetrates into the nail bed. Read More

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