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    Variants at the OCA2/HERC2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs.
    Br J Dermatol 2017 Apr 29. Epub 2017 Apr 29.
    Department of Internal Medicine, Division of Human Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
    Background: Variants at the Oculocutaneous albinism 2 (OCA2)/ HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 2 (HERC2) locus have been associated with pigmentation phenotypes as well as risk of developing multiple types of skin cancer.

    Objectives: The goal of this study was to evaluate OCA2/HERC2 locus variants for impact on time to develop cutaneous squamous cell carcinoma (cSCC) in organ transplant recipients (OTRs) who are at elevated risk of developing cSCC.

    Methods: Participants were solid organ transplant recipients ascertained from two centers (n=125 and 261) with an average of 13. Read More

    Gene Expression Signature Differentiates Histology But Not Progression Status of Early-Stage NSCLC.
    Transl Oncol 2017 Apr 26;10(3):450-458. Epub 2017 Apr 26.
    Department of Histology and Embryology, Medical University of Bialystok, Waszyngtona 13, Bialystok 15-269, Poland. Electronic address:
    Advances in molecular analyses based on high-throughput technologies can contribute to a more accurate classification of non-small cell lung cancer (NSCLC), as well as a better prediction of both the disease course and the efficacy of targeted therapies. Here we set out to analyze whether global gene expression profiling performed in a group of early-stage NSCLC patients can contribute to classifying tumor subtypes and predicting the disease prognosis. Gene expression profiling was performed with the use of the microarray technology in a training set of 108 NSCLC samples. Read More

    PD-L1 expression as poor prognostic factor in patients with non-squamous non-small cell lung cancer.
    Oncotarget 2017 Apr 11. Epub 2017 Apr 11.
    Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.
    Objectives: The role of programmed cell death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC), especially according to histologic type, remains controversial. The purpose of this study was to assess PD-L1 expression and its association with overall survival (OS) and clinicopathologic characteristics in NSCLC.

    Material And Methods: Formalin-fixed paraffin-embedded specimens were obtained from 108 patients with surgically resected primary NSCLC. Read More

    Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor.
    Oncotarget 2017 Apr 10. Epub 2017 Apr 10.
    Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
    Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family of enzymes detoxify both exogenous and endogenous aldehydes. Since many chemotherapeutic agents, such as cisplatin, result in the generation of cytotoxic aldehydes and oxidative stress, we hypothesized that cells expressing high levels of ALDH may be more chemoresistant due to their increased detoxifying capacity and that inhibitors of ALDHs may sensitize them to these drugs. Read More

    Evaluation of Merkel cell polyomavirus in non-small cell lung cancer and adjacent normal cells.
    Microb Pathog 2017 Apr 25. Epub 2017 Apr 25.
    Departments of Mycobacteriology & Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
    Several risk factors have been linked to lung cancer (LC). Nevertheless, a viral etiology has been mentioned for a subset of patients developing LC. The aim of this study was to evaluate the effect of Merkel cell polyomavirus (MCPyV) on developing non-small cell lung cancer (NSCLCs). Read More

    Salinomycin acts through reducing AKT-dependent thymidylate synthase expression to enhance erlotinib-induced cytotoxicity in human lung cancer cells.
    Exp Cell Res 2017 Apr 25. Epub 2017 Apr 25.
    Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan. Electronic address:
    Erlotinib (Tarceva(R)) is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor in the treatment of human non-small cell lung cancer (NSCLC). Salinomycin, a polyether antibiotic, has been promising a novel therapeutic agent for lung cancer, and down-regulated the expression of thymidylate synthase (TS) in NSCLC cell lines. Previous study showed that against EGFR and TS was strongly synergistic cytotoxicity in NSCLC cells. Read More

    Effects of irradiation on radioresistance, HOTAIR and epithelial-mesenchymal transition/cancer stem cell marker expression in esophageal squamous cell carcinoma.
    Oncol Lett 2017 Apr 23;13(4):2751-2757. Epub 2017 Feb 23.
    Endoscopic Diagnosis and Treatment Center, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China.
    Radiotherapy is a common therapeutic strategy used to treat esophageal squamous cell carcinoma (ESCC). However, tumor cells often develop radioresistance, thereby reducing treatment efficacy. Here, we aimed to identify the mechanisms through which ESCC cells develop radioresistance and identify associated biomarkers. Read More

    Prognostic value of MLH1 promoter methylation in male patients with esophageal squamous cell carcinoma.
    Oncol Lett 2017 Apr 22;13(4):2745-2750. Epub 2017 Feb 22.
    Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
    The DNA mismatch repair (MMR) gene MutL homolog 1 (MLH1) is critical for the maintenance of genomic integrity. Methylation of the MLH1 gene promoter was identified as a prognostic marker for numerous types of cancer including glioblastoma, colorectal, ovarian and gastric cancer. The present study aimed to determine whether MLH1 promoter methylation was associated with survival in male patients with esophageal squamous cell carcinoma (ESCC). Read More

    Prognostic and predictive role of COX-2, XRCC1 and RASSF1 expression in patients with esophageal squamous cell carcinoma receiving radiotherapy.
    Oncol Lett 2017 Apr 24;13(4):2549-2556. Epub 2017 Feb 24.
    Department of Radiation Oncology, Anyang Cancer Hospital, Anyang, Henan 455000, P.R. China.
    Identification of biomarkers for predicting radiosensitivity would be useful for administering individualized radiotherapy (RT) to patients with esophageal cancer. The aim of the present study was to evaluate the association between cyclooxygenase-2 (COX-2), X-ray repair cross complementing group 1 (XRCC1), ras association domain family 1 (RASSF1) protein expression, clinicopathological characteristics, radiosensitivity and survival rate in 76 patients with esophageal squamous cell carcinoma (ESCC) who were treated with RT. Positive expression of COX-2, XRCC1 and RASSF1 was identified by immunohistochemistry in 81. Read More

    Cytokeratin 17 and Ki-67: Immunohistochemical markers for the differential diagnosis of keratoacanthoma and squamous cell carcinoma.
    Oncol Lett 2017 Apr 1;13(4):2539-2548. Epub 2017 Mar 1.
    Department of Pathology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey.
    The clinical and histopathological distinction between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is essential, but frequently difficult to make. The utility of CK17 and Ki-67 expression in distinguishing between KA and SCC was investigated. Immunohistochemical staining patterns for CK17 and Ki-67 were evaluated in 24 KA and 27 SCC cases. Read More

    KLF7 overexpression in human oral squamous cell carcinoma promotes migration and epithelial-mesenchymal transition.
    Oncol Lett 2017 Apr 13;13(4):2281-2289. Epub 2017 Feb 13.
    Department of Stomatology, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, P.R. China.
    Krüppel-like factor 7 (KLF7) is a member of the KLF family of zinc finger transcription factors, and was the first KLF cloned using complementary DNA and polymerase chain reaction (PCR) techniques with human vascular endothelial cells as a template. In addition, KLF7 is known as the ubiquitous Krüppel-like factor, as it is widely expressed in numerous human tissues at low levels. In the present study, the function of KLF7 in migration and epithelial-mesenchymal transition (EMT), which are associated with tumor progression, was investigated in human oral squamous cell carcinoma (OSCC) cells. Read More

    Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
    Oncol Lett 2017 Apr 7;13(4):2237-2243. Epub 2017 Feb 7.
    Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
    Calpains are a family of intracellular cysteine proteases involved in various biological processes. Previously, the family was identified to have abnormal expression in several types of malignant tumor. Calpain 6 was less well known; however, it was recently identified to be involved in the carcinogenesis of certain types of malignant tumor. Read More

    Galectin-7 promotes the invasiveness of human oral squamous cell carcinoma cells via activation of ERK and JNK signaling.
    Oncol Lett 2017 Mar 25;13(3):1919-1924. Epub 2017 Jan 25.
    Department of Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, P.R. China.
    Galectin-7 is a member of the β-galactoside-binding protein family, and is highly expressed in oral squamous cell carcinoma (OSCC). The aim of the present study was to investigate the effects of manipulating galectin-7 expression on the biological phenotype of human OSCC cells and the associated molecular mechanisms. Knockdown of endogenous galectin-7 via small interfering RNA (siRNA) was performed and cell proliferation, apoptosis, migration, and invasion were subsequently assessed. Read More

    Promoter hypermethylation of the RECK gene is associated with its low expression and poor survival of esophageal squamous cell carcinoma.
    Oncol Lett 2017 Mar 27;13(3):1911-1918. Epub 2017 Jan 27.
    Clinical Oncology Laboratory, Changzhou Cancer Hospital of Soochow University, Changzhou, Jiangsu 213002, P.R. China.
    The present study aimed to investigate the association between the methylation status of the reversion-inducing cysteine-rich protein with kazal motifs (RECK) gene and its mRNA expression levels in patients with esophageal squamous cell carcinoma (ESCC). The methylation status of RECK was analyzed by methylation-specific polymerase chain reaction (PCR), and RECK mRNA expression levels were analyzed by quantitative PCR, in 310 paired ESCC tissues. The mean RECK methylation index (MI) was 0. Read More

    Characterization of topoisomerase II α and minichromosome maintenance protein 2 expression in anal carcinoma.
    Oncol Lett 2017 Mar 25;13(3):1891-1898. Epub 2017 Jan 25.
    Molecular Oncology Research Center, Barretos Cancer Hospital, Pio XII Foundation, Barretos, São Paulo, SP 14784-400, Brazil.
    The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the human papillomavirus (HPV) statuses of these lesions and characterize the immunohistochemical expression levels of TOP2A and MCM2 in anal carcinoma, as these are important markers for cervical HPV-induced lesions; their expression was also compared with respect to p16 and Ki-67. The vast majority of the cases tested positive for HPV16 (84%); 1 case tested positive for both HPV16 and HPV18. Read More

    Promoter methylation and expression of Raf kinase inhibitory protein in esophageal squamous cell carcinoma.
    Oncol Lett 2017 Mar 18;13(3):1866-1872. Epub 2017 Jan 18.
    Department of Pathology, The Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056000, P.R. China.
    Raf kinase inhibitory protein (RKIP) regulates multiple cellular processes, and its downregulation is associated with distinct human cancers. In the present study, the status of RKIP promoter methylation, as well as its expression and clinical significance in esophageal squamous cell carcinoma (ESCC), were examined. The promoter methylation status in the 5'-CpG island of the RKIP gene and the expression level of the RKIP protein were examined using a modified methylation-specific polymerase chain reaction (MSP) method and immunohistochemical staining, respectively, in 77 ESCC samples and matched paratumor normal tissues. Read More

    Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma.
    Oncol Lett 2017 Mar 25;13(3):1819-1825. Epub 2017 Jan 25.
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
    Heat-shock factor 1 (HSF1) is the primary regulator of the response to various stressors. A previous study showed that HSF1 expression is associated with a poor prognosis in breast cancer and hepatocellular carcinoma; however, the prognostic significance of HSF1 in esophageal squamous cell carcinoma (ESCC) is unknown. Therefore, the present study investigated the association between HSF1 expression and the clinicopathological parameters of patients, as well as the association between HSF1 expression, and heat shock protein (Hsp)27, Hsp70 and Hsp90 expression induced by HSF1, by cDNA microarray and immunohistochemistry analyses. Read More

    The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma.
    Oncol Lett 2017 Mar 25;13(3):1761-1766. Epub 2017 Jan 25.
    Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874-0838, Japan.
    Esophageal squamous cell carcinoma (ESCC) has high biological malignant potential among the various digestive tract cancers and is associated with a poor prognosis. To identify novel genes involved in tumor progression, the present study analyzed the genetic and transcriptional alterations in two clinical cohorts, totaling 157 cases of ESCC (78 cases from the discovery set and 79 cases from the validation set). From the discovery set, gene expression and copy number profiles were analyzed using expression arrays and array-comparative genomic hybridization, respectively. Read More

    Cisplatin plus vinorelbine as induction treatment in stage IIIA non-small cell lung cancer.
    Oncol Lett 2017 Mar 18;13(3):1647-1654. Epub 2017 Jan 18.
    Department of Clinical Oncology, Puerta de Hierro Hospital, 28222 Madrid, Spain.
    Survival rates in patients with stage IIIA non-small cell lung cancer (NSCLC) remain low despite curative treatment. This is due to tumor recurrence at distant sites. The aim of neoadjuvant chemotherapy (NA-CT) is to eradicate occult micrometastatic disease and improve survival in patients that are not candidates for surgery following induction therapy. Read More

    Immunohistochemical profile of ING3 protein in normal and cancerous tissues.
    Oncol Lett 2017 Mar 23;13(3):1631-1636. Epub 2017 Jan 23.
    Cancer Center, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China.
    The inhibitor of growth family, member 3 (ING3) protein may be capable of blocking the cell cycle via activating p53-transactivated promoters of p21 and Bcl2-associated X protein, and may induce apoptosis via a Fas/caspase-8-dependent signaling pathway. In the present study, immunohistochemistry was performed in order to characterize the expression profile of ING3 protein in tissue microarrays containing mouse and human normal tissue, human hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), ovarian (n=208), endometrial (n=96) and lung carcinoma (n=192). In mouse tissue, ING3 protein was positively detected in the cytoplasm of cardiomyocytes, kidney and skeletal muscle cells, and was additionally detected in the cytoplasm and nucleus of bronchial and alveolar epithelium, gastric and intestinal gland, and mammary gland cells. Read More

    TCRP1 expression is associated with platinum sensitivity in human lung and ovarian cancer cells.
    Oncol Lett 2017 Mar 27;13(3):1398-1405. Epub 2016 Dec 27.
    Affiliated Cancer Hospital and Cancer Research Institute, Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.
    Platinum-based drugs, including cisplatin (DDP) and oxaliplatin (L-OHP), are among the most potent chemotherapy drugs, and are widely utilized for the treatment of human lung and ovarian cancer. However, certain patients do not respond to platinum-based agents, and even those who initially benefit from the treatment will eventually exhibit resistance to these drugs. Although certain factors have been investigated for their potential to predict platinum resistance, more effective predictors for the improved management of patients with lung and ovarian cancer are required. Read More

    Characteristics and outcome of laryngeal squamous cell carcinoma in young adults.
    Oncol Lett 2017 Mar 21;13(3):1393-1397. Epub 2016 Dec 21.
    Department of Clinical Otolaryngology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
    Laryngeal carcinoma rarely occurs in the young adult population. Therefore, the optimal treatment for this age group is unclear, specifically regarding organ preservation treatment. In order to assess the distinct characteristics of laryngeal squamous cell carcinoma (SCC) in young adults and describe the effect of treatment on survival, a retrospective chart review of all patients aged <40 years, who were treated in a tertiary referral center for laryngeal SCC between January 1960 and December 2013, was performed. Read More

    Expression and clinical significance of YAP in laryngeal squamous cell carcinoma patients.
    Oncol Lett 2017 Mar 27;13(3):1311-1314. Epub 2016 Dec 27.
    Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China.
    The aim of the present study was to investigate the expression levels of Yes-associated protein (YAP) in different grades of laryngeal squamous cell carcinoma (LSCC) tissues and vocal cord polyps tissues, and to investigate any correlations with clinical factors. The expression of YAP in 128 cases of LSCC and 10 cases of vocal cord polyps tissues was tested using immunohistochemistry. YAP was primarily present in the nucleus of LSCC and controls, whereas phosphorylated YAP expression was present in the cytoplasm. Read More

    Squamous cell carcinoma antigen expression in tumor cells is associated with the chemosensitivity and survival of patients with cervical cancer receiving docetaxel-carboplatin-based neoadjuvant chemotherapy.
    Oncol Lett 2017 Mar 2;13(3):1235-1241. Epub 2017 Jan 2.
    Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
    The present study examined the association between squamous cell carcinoma antigen (SCCA) expression and the response of patients with cervical cancer to docetaxel-carboplatin (DC) combination chemotherapy, in order to determine the prognostic potential of SCCA expression. A total of 21 patients were enrolled with stage IB2 or stage IIA2 SCC. Of these, 9 patients had chemotherapy-sensitive cancer (2 cases with a complete response and 7 cases with a partial response) and 12 patients had chemotherapy-resistant cancer (12 cases of stable disease and no cases of progressive disease). Read More

    MicroRNA-31 functions as an oncogenic microRNA in cutaneous squamous cell carcinoma cells by targeting RhoTBT1.
    Oncol Lett 2017 Mar 2;13(3):1078-1082. Epub 2017 Jan 2.
    Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
    Cutaneous squamous cell carcinoma (cSCC) is a malignancy of epidermal keratinocytes that is responsible for ~20% of annual skin cancer-associated mortalities. Accumulating evidence demonstrates that the dysregulation of micro (mi)RNAs serves a significant role in the tumorigenesis and progression of human cSCC. MicroRNA-31 (miR-31) is upregulated in cSCC and is involved in cSCC development. Read More

    Relevance of CCL3/CCR5 axis in oral carcinogenesis.
    Oncotarget 2017 Apr 6. Epub 2017 Apr 6.
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    The chemokine CCL3 is a chemotactic cytokine crucial for inflammatory cell recruitment in homeostatic and pathological conditions. CCL3 might stimulate cancer progression by promoting leukocyte accumulation, angiogenesis and tumour growth. The expression of CCL3 and its receptors CCR1 and CCR5 was demonstrated in oral squamous cell carcinoma (OSCC), but their role was not defined. Read More

    Histological Assessment of the Carotid Sheath in Patients With Oral Squamous Cell Carcinoma.
    J Oral Maxillofac Surg 2017 Apr 4. Epub 2017 Apr 4.
    Reader, Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
    Purpose: During surgical management of the neck using various types of neck dissection, the carotid sheath is removed, in particular, the part adjacent to the jugular lymph node chain, with the intention of preventing recurrence from the lymphatics present in it. The role of the carotid sheath as a potential origin for nodal recurrence has not been proved thus far. Working in a tissue plane between the carotid sheath and the neurovascular structures of the neck can lead to a greater chance of damage to these structures. Read More

    Comparing docetaxel plus cisplatin versus fluorouracil plus cisplatin in esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy.
    Jpn J Clin Oncol 2017 Apr 27:1-7. Epub 2017 Apr 27.
    State Key Laboratory of Oncology in South China, Guangdong Esophageal Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Guangzhou.
    Objective: The optimal neoadjuvant chemoradiotherapy (CRT) regimen in esophageal cancer has not yet been defined. This study was aimed to compare the differences in pathologic response and survival between docetaxel/cisplatin and fluorouracil/cisplatin as neoadjuvant CRT in locally advanced esophageal squamous cell carcinoma (SCC).

    Methods: We retrospectively analyzed patients with thoracic esophageal SCC who received neoadjuvant CRT followed by esophagectomy from 2000 to 2014. Read More

    Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment?
    Interact Cardiovasc Thorac Surg 2017 May;24(5):792-795
    Comprehensive Wards, Sichuan Cancer Hospital and Institute, Chengdu, China.
    A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment?' Altogether, 659 articles were found using the reported search, of which 8 represented the best evidence to answer the clinical question. The authors, journal, date, country of publication, patient group studied, study type, relevant outcomes and results of these articles were tabulated. Read More

    Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal.
    Ann Oncol 2017 May;28(5):1036-1041
    Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Nantes, France.
    Background: Safety and efficacy of pembrolizumab, a humanized programmed death 1 monoclonal antibody, was assessed in KEYNOTE-028, a multicohort, phase Ib trial for patients with programmed death ligand 1 (PD-L1)-positive advanced solid tumors. We report results for the cohort of patients with advanced anal carcinoma.

    Patients And Methods: Patients with PD-L1-positive tumors (≥1%) received intravenous pembrolizumab 10 mg/kg once every 2 weeks for up to 2 years or until confirmed progression or unacceptable toxicity. Read More

    High-risk human papillomavirus in anal squamous cell carcinoma: a 'conservative' leading role.
    Ann Oncol 2017 May;28(5):1160
    Unit of Gastrointestinal and Neuroendocrine Tumors; 2Division of Pathology; 3Unit of Viral Control of Cellular Pathways and Biology of Tumorigenesis; 4Divisions of Radiotherapy; 5Endoscopy; 6General Surgery; 7Hepatobiliary and Pancreatic Surgery, European Institute of Oncology (IEO), Milan, Italy.

    High expression of LAMP2 predicts poor prognosis in patients with esophageal squamous cell carcinoma.
    Cancer Biomark 2017 Apr 21. Epub 2017 Apr 21.
    Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
    Background: LAMP2 is one of the major protein components of lysosome. In addition to the expression on the lysosomal membrane, LAMP2 has also been found relocalizing to the cell surface of some highly metastatic tumor cells.

    Objective: The aim of this study was to detect the expression levels of LAMP2 and discuss its roles in esophageal squamous cell carcinoma (ESCC). Read More

    Up-regulated miR-221 expression as a molecular diagnostic marker in laryngeal squamous cell carcinoma and its correlation with Apaf-1 expression.
    Cancer Biomark 2017 Apr 21. Epub 2017 Apr 21.
    Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: Despite the improvement in the diagnosis and the management of laryngeal squamous cell carcinoma (LSCC), many patients with advanced-stage have poor prognosis in the form of recurrence, metastasis or death. So, recognition of new molecular markers would facilitate the development of targeted therapies.

    Objectives: To investigate miR-221 expression in LSCC and its possible correlation to apoptotic protease activating factor-1 (Apaf-1). Read More

    The synergic effect of HPV infection and epigenetic anomaly of the p16 gene in the development of cervical cancer.
    Cancer Biomark 2017 Apr 14. Epub 2017 Apr 14.
    Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.
    Background: Cervical cancer is the most common cancer in Indian women. Infection with a high-risk human papillomavirus (HR-HPV) is the greatest risk factor for developing cervical cancer. The genetic and epigenetic changes in the tumor suppressor p16 gene is play an important role in the development of cervical cancer. Read More

    Oxytocin inhibits head and neck squamous cell carcinoma cell migration by early growth response-1 upregulation.
    Anticancer Drugs 2017 Apr 27. Epub 2017 Apr 27.
    Departments of aOral Microbiology and Immunology bOral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, South Korea.
    The effect of oxytocin (OXT) on cancer invasion is controversial. Few studies have examined the effect of early growth response-1 (EGR1) on the invasion of head and neck squamous cell carcinoma (HNSCC). Here, we evaluated how EGR1 affects HNSCC cell migration through the molecular mechanism of OXT in exerting anti-invasion activity. Read More

    CARCINOSARCOMA OF SKIN (SARCOMATOID CARCINOMA) - A RARE NON-MELANOMA SKIN CANCER (CASE REVIEW).
    Georgian Med News 2017 Feb(263):7-10
    Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology; Institute of Pathology "Georg Schmorl"; Dresden, Germany; Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    Non-melanoma skin cancer incidence is rising worldwide. The leading neoplasias are basal cell carcinoma and squamous cell carcinoma. We report on an 88-year-old female patient with a rapidly grown, symptomless, exophytic tumor of the supraclavicular area. Read More

    Postoperative radiotherapy for patients with oral squamous cell carcinoma with intermediate risk of recurrence: A case match study.
    Head Neck 2017 Apr 28. Epub 2017 Apr 28.
    Liverpool Head and Neck Cancer Unit, Aintree University Hospital, Liverpool, Merseyside, United Kingdom.
    Background: The purpose of this study was to determine the effect of postoperative radiotherapy (PORT) on recurrence and survival in patients with oral squamous cell carcinoma (OSCC) of intermediate recurrence risk.

    Methods: Intermediate risk patients, defined as pT1, pT2, pN0, or pN1 with at least one adverse pathological feature (eg, lymphovascular/perineural invasion), were identified from the head and neck databases of the Liverpool Head and Neck Cancer Unit and the Sydney Head and Neck Cancer Institute. Patients who received surgery and PORT were case matched with patients treated by surgery alone based on pN, pT, margins, and pathological features. Read More

    Prognostic survival value of retropharyngeal lymph node involvement in sinonasal tumors: A retrospective, descriptive, and exploratory study.
    Head Neck 2017 Apr 28. Epub 2017 Apr 28.
    Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.
    Background: Sinonasal carcinomas are rare. The purpose of this study was for us to present our assessment of the effects of retropharyngeal lymph node involvement at diagnosis on patient outcomes.

    Methods: Retropharyngeal lymph node involvement in 36 patients with sinonasal carcinoma was determined by radiology at initial presentation. Read More

    Role of EGFR as prognostic factor in head and neck cancer patients treated with surgery and postoperative radiotherapy: proposal of a new approach behind the EGFR overexpression.
    Med Oncol 2017 Jun 27;34(6):107. Epub 2017 Apr 27.
    Department of Radiotherapy, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.
    In an era of personalized treatment, there is a great interest in identifying factors which might predict patient response to radiotherapy (RT). The role of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma (HNSCC) remains still controversial. We performed a retrospective analysis on the prognostic value of EGFR in HNSCC patients treated with surgery and postoperative RT through a semiquantitative immunohistochemical analysis of EGFR membrane expression. Read More

    [Costal metastasis revealing esophageal squamous cell carcinoma].
    Pan Afr Med J 2017 18;26:23. Epub 2017 Jan 18.
    Service d'Hépato-Gastroentérolgie, Hôpital Géneral de Grand Yoff, (HOGGY) Dakar, Sénégal.
    Esophageal cancer is associated with poor prognosis. Its severity is linked to delayed diagnosis which is most often made once a cancer has metastasized, in Africa. Costal metastases are rare. Read More

    Clinico-Pathological Patterns of Patients Who Underwent Orbital Exenteration in a Tertiary Eye Hospital of Nepal.
    Ethiop J Health Sci 2016 Nov;26(6):543-548
    Tilganga Institute Of Ophthalmology, Nepal.
    Background: Orbital exenteration is a destructive procedure performed by removing all or part of the orbital contents along with entire eyeball. It is a procedure reserved for life threatening malignancies and some nonmalignant disorders which are not controlled by conservative management.

    Methods: This is a retrospective study done on patients who underwent orbital exenteration at Tilganga Institute of Ophthalmology from1 January 2006- 30 in December 2014. Read More

    Solid Lymph Nodes as an Imaging Biomarker for Risk Stratification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma.
    AJNR Am J Neuroradiol 2017 Apr 27. Epub 2017 Apr 27.
    From the Departments of Radiology (T.J.R., M.A.H., B.F.B.), Otolaryngology (T.J.R., M.A.H., R.L.F., B.F.B.), and Pathology (S.I.C.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Department of Radiology (S.N.), Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
    Background And Purpose: Human papillomavirus-related oropharyngeal squamous cell carcinoma is associated with cystic lymph nodes on CT and has a favorable prognosis. A subset of patients with aggressive disease experience treatment failure. Our aim was to determine whether the extent of cystic lymph node burden on staging CT can serve as an imaging biomarker to predict treatment failure in human papillomavirus-related oropharyngeal squamous cell carcinoma. Read More

    The effect of submandibular gland preservation during level 1B neck dissection on postoperative xerostomia.
    Auris Nasus Larynx 2017 Apr 24. Epub 2017 Apr 24.
    Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California-San Francisco, San Francisco, CA, USA.
    Objective: Compare the presence and degree of postoperative xerostomia following preservation or excision of the submandibular gland (SMG) during level IB neck dissection (ND) without adjuvant radiation.

    Methods: Retrospective review with patient questionnaire administered to patients with pT1-2N0 oral squamous cell carcinoma (SCC) who underwent resection and ND with SMG preservation or SMG excision without postoperative radiation from 2011 to 2015. We analyzed an additional control group that was age and gender-matched and had not undergone oral resection or SMG excision. Read More

    The mechanisms of radioresistance in esophageal squamous cell carcinoma and current strategies in radiosensitivity.
    J Thorac Dis 2017 Mar;9(3):849-859
    Department of Radiation Oncology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
    Esophageal cancer is the eighth most common cancer and the sixth leading cause of cancer-related death worldwide. Surgery is the primary form of treatment, but the survival is poor, especially for patients with locally advanced esophageal cancer. Radiotherapy has been a critical treatment option that may be combined with chemotherapy in patients with unresectable esophageal cancer. Read More

    Definitive concurrent chemoradiotherapy with S-1 and cisplatin in elderly esophageal squamous cell carcinoma patients.
    J Thorac Dis 2017 Mar;9(3):646-654
    Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
    Background: To evaluate the feasibility and efficiency of definitive concurrent chemoradiotherapy (dCRT) with S-1 and cisplatin for elderly esophageal squamous cell carcinoma (ESCC) patients.

    Methods: Fifty-six elderly patients were included from January 2012 to December 2014. Patients received S-1 (tegafur/gimeracil/oteracil) and cisplatin at doses of 70 mg/m(2)/day for two weeks and 75 mg/m(2) on day 1, respectively, every 3 weeks. Read More

    CD90 positive cells exhibit aggressive radioresistance in esophageal squamous cell carcinoma.
    J Thorac Dis 2017 Mar;9(3):610-620
    Department of Radiation Oncology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
    Background: Cancer stem cells (CSCs) are widely abundant and considered to be an important factor in therapy resistance. They are also promising potential targets for conquering tumors. We explored the effects of radiation on stem cell-like tumor cells via the candidate marker CD90 to provide new ideas for the comprehensive treatment of esophageal squamous cell carcinoma (ESCC). Read More

    Is Human Oxoguanine Glycosylase 1 Genetic Variant Successful Even on Oral Squamous Cell Carcinoma?
    Pathobiology 2017 Apr 28. Epub 2017 Apr 28.
    Department of Otolaryngology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Background: Oral squamous cell carcinoma (OSCC) is one of the most widespread cancer types that arise from different sites of oral cavity and has a 5-year survival rate. This study is aimed at investigating the human oxoguanine glycosylase 1 (hOGG1)-Ser326Cys and APE-Asp148Glu polymorphisms of DNA repair genes in OSCC.

    Materials And Methods: We investigated the hOGG1-Ser326Cys and APE-Asp148Glu polymorphisms of DNA repair genes in the oral cavity. Read More

    Prognostic Indication of Sarcopenia for Wound Complication After Total Laryngectomy.
    JAMA Otolaryngol Head Neck Surg 2017 Apr 27. Epub 2017 Apr 27.
    Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland.
    Importance: Postoperative wound complications after total laryngectomy (TL) increase hospital stay, costs, and delay adjuvant therapy when indicated. Recently, sarcopenia has been identified as a predictor of postoperative complications in patients undergoing major surgery but has not been assessed in head and neck surgery patients.

    Objective: To determine the incidence of sarcopenia in patients with squamous cell carcinoma (SCC) undergoing TL and evaluate its association with the development of postoperative wound complications. Read More

    Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer.
    JAMA Otolaryngol Head Neck Surg 2017 Apr 27. Epub 2017 Apr 27.
    Department of Otolaryngology-Head & Neck Surgery, Western University, London, Ontario, Canada4London Regional Cancer Program, London, Ontario, Canada5Lawson Health Research Institute, London, Ontario, Canada.
    Importance: Locoregional recurrence of oral cavity squamous cell carcinoma (OCSCC) continues to be a life-threatening and difficult clinical situation. Salvage surgery can result in significant morbidities, and survival following recurrence is poor.

    Objective: To outline prognostic factors influencing overall survival (OS) following salvage surgery for OCSCC to guide management of treatment for patients with locoregionally recurrent disease. Read More

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