132 results match your criteria Spur Cell Anemia


Spur-Cell Anemia.

N Engl J Med 2018 Aug;379(8):774

Oregon Health and Science University, Portland, OR

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMicm1714572DOI Listing
August 2018
6 Reads

Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis.

Case Rep Hematol 2018 21;2018:9513946. Epub 2018 Jun 21.

Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, Japan.

Background: Spur cell anemia (SCA) is a cause of hemolytic anemia in patients with alcoholic liver cirrhosis. Because dyslipidemia is related to the development of spur cells, SCA was previously treated with plasmapheresis.

Case Report: A 52-year-old Japanese man with SCA associated with alcoholic liver cirrhosis (Child-Pugh C) underwent two rounds of plasmapheresis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/9513946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033239PMC
June 2018
4 Reads

High-dose steroids as a therapeutic option in the management of spur cell haemolytic anaemia.

BMJ Case Rep 2018 Jan 31;2018. Epub 2018 Jan 31.

Medical Oncology/Medicine, Captain James A. Lovell Federal Health Care Center, North Chicago, Illinois, USA.

Spur cell haemolytic anaemia (SCA) is a form of anaemia that can be seen in patients with severely impaired liver function or advanced cirrhosis. It is associated with high mortality. The treatment options for SCA secondary to cirrhosis are limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2017-223281DOI Listing
January 2018
8 Reads

Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance.

Dig Dis Sci 2018 Jan 25;63(1):16-26. Epub 2017 Nov 25.

Department of Clinical and Experimental Medicine, Garibaldi Hospital, University of Catania, Via Palermo, 636, 95122, Catania, Italy.

Progressive lipoprotein impairment occurs in liver cirrhosis and is associated with increased morbidity and mortality. The present review aims to summarize the current evidence regarding the prognostic value of lipoprotein abnormalities in liver cirrhosis and to address the need of a better prognostic stratification of patients, including lipoprotein profile assessment. Low levels of lipoproteins are usual in cirrhosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-017-4862-xDOI Listing
January 2018
6 Reads

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis.

Blood 2017 12 6;130(25):2786-2798. Epub 2017 Nov 6.

Institute for Pathophysiology, West German Heart and Vascular Center and.

The hepatocyte nuclear factor (HNF) family regulates complex networks of metabolism and organ development. Human mutations in its prototypical member HNF1A cause maturity-onset diabetes of the young (MODY) type 3. In this study, we identified an important role for HNF1A in the preservation of erythrocyte membrane integrity, calcium homeostasis, and osmotic resistance through an as-yet unrecognized link of HNF1A to sphingolipid homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-03-774356DOI Listing
December 2017
13 Reads

Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.

Clin Chim Acta 2017 May 20;468:81-84. Epub 2017 Feb 20.

Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

Introduction: Inherited anemias diagnostic workup requires a step-wise algorithm. Causal genes implicated in congenital hemolytic anemia are numerous, making a gene-by-gene approach by Sanger sequencing time consuming, expensive and labour intensive. Targeted resequencing can be of great use in explaining these cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2017.02.012DOI Listing
May 2017
25 Reads
1 Citation
2.820 Impact Factor

Unusual Anemias.

Med Clin North Am 2017 Mar 10;101(2):417-429. Epub 2016 Dec 10.

Division of Hematology/Medical Oncology, Department of Medicine, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201-3098, USA; Division of Hematology/Medical Oncology, Department of Medicine, Knight Cancer Institute, Oregon Health and Science University, MC L586, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:

Many processes lead to anemia. This review covers anemias that are less commonly encountered in the United States. These anemias include hemoglobin defects like thalassemia, bone marrow failure syndromes like aplastic anemia and pure red cell aplasia, and hemolytic processes such as paroxysmal nocturnal hemoglobinuria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mcna.2016.09.011DOI Listing
March 2017
6 Reads

Spur cell anemia in Wilson's disease: a rare presentation.

Int J Lab Hematol 2017 Jun 22;39(3):e64-e65. Epub 2016 Dec 22.

Department of Pediatrics, UCMS and GTB Hospital, New Delhi, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijlh.12613DOI Listing
June 2017
6 Reads

An unusual cause of anemia in cirrhosis: spur cell anemia, a case report with review of literature.

Gastroenterol Hepatol Bed Bench 2016 ;9(4):335-339

Department of Clinical and Experimental Medicine, Garibaldi Hospital, University of Catania, Italy.

Chronic anemia is common in liver cirrhosis. In this setting, the pathogenesis of anemia is complex and multifactorial. Spur cell anemia is a serious disorder in cirrhotic patients and is associated with poor prognosis. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118860PMC
January 2016
8 Reads

Spur cell hemolytic anemia in liver failure.

Transfusion 2016 Apr;56(4):787-8

University of Washington, Harborview Medical Center, Seattle, Washington.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.13407DOI Listing
April 2016
8 Reads

Spur cell anemia in the setting of progressive liver allograft failure.

Am J Hematol 2016 Oct 22;91(10):1061. Epub 2016 Mar 22.

Division of Hematology, Mayo Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajh.24331DOI Listing
October 2016
7 Reads

[Spur cell anemia].

Rev Clin Esp 2016 May 5;216(4):233. Epub 2015 Dec 5.

Servicio de Hematología, Hospital Universitario de Móstoles, Móstoles, Madrid, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rce.2015.09.013DOI Listing
May 2016
6 Reads

A mechanism for the suppression of homologous recombination in G1 cells.

Nature 2015 Dec 9;528(7582):422-6. Epub 2015 Dec 9.

The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

DNA repair by homologous recombination is highly suppressed in G1 cells to ensure that mitotic recombination occurs solely between sister chromatids. Although many homologous recombination factors are cell-cycle regulated, the identity of the events that are both necessary and sufficient to suppress recombination in G1 cells is unknown. Here we report that the cell cycle controls the interaction of BRCA1 with PALB2-BRCA2 to constrain BRCA2 function to the S/G2 phases in human cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature16142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880051PMC
December 2015
10 Reads

Klippel-Trenaunay syndrome presenting with acanthocytosis and splenic and retroperitoneal lymphangioma: a case report.

J Med Case Rep 2014 Nov 27;8:390. Epub 2014 Nov 27.

Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 08, Sri Lanka.

Introduction: Klippel-Trenaunay syndrome is a rare congenital mesodermal abnormality characterized by bone and soft tissue hypertrophy, extensive hemangioma and venous abnormalities. We report the case of a patient with two additional rare clinical manifestations in the background of Klippel-Trenaunay syndrome, namely, acanthocytosis and splenic and retroperitoneal lymphangioma.

Case Presentation: A 24-year-old Sri Lankan man from North Central Province in Sri Lanka presented to our general medical unit with symptomatic anaemia. Read More

View Article

Download full-text PDF

Source
http://jmedicalcasereports.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/1752-1947-8-390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289367PMC
November 2014
19 Reads

Reappraisal of the etiology of extracorpuscular non-autoimmune acquired hemolytic anemia in 2657 hospitalized patients with non-neoplastic disease.

Clin Med Insights Pathol 2014 15;7:11-4. Epub 2014 Apr 15.

Institute of Environmental Health, China Medical University College of Public Health, Taichung, Taiwan.

Introduction: Unlike autoimmune hemolytic anemia (AIHA), literature on the etiological study of non-autoimmune hemolytic anemia (non-AIHA) is scarce. The incidence and prevalence of non-AIHA in different geographic regions are largely unknown perhaps owing to the lack of perspective investigation and different profiles of etiologies from different geographic regions. We aimed to examine the real-world etiology or mechanisms of the non-hereditary non-AIHA from a nationwide population-based administrative claim database in Taiwan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/CPath.S14875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999811PMC
May 2014
14 Reads

[Clinical and experimental studies of adult hereditary spherocytosis].

Authors:
Qing He Jun Xue

Zhonghua Yi Xue Za Zhi 2014 Mar;94(8):603-5

Department of Hematology, Affiliated Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China. Email:

Objective: To explore the clinical characteristic of adult hereditary spherocytosis (HS) and the efficacies of splenectomy.

Methods: Six cases with adult HS were collected from July 2006 to July 2012. And their clinical features, laboratory profile and treatment were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
March 2014
6 Reads

Severe mixed-type iron overload in alcoholic cirrhosis related to advanced spur cell anemia.

Ann Hepatol 2014 May-Jun;13(3):396-8

Department of Medicine II, Saarland University Medical Center, Homburg, Germany.

View Article

Download full-text PDF

Source
January 2015
4 Reads

Clinical, hematological, and imaging observations in a 25-year-old woman with abetalipoproteinemia.

Ann Indian Acad Neurol 2014 Jan;17(1):113-6

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Abetalipoproteinemia is an uncommon cause of ataxia and retinitis pigmentosa (RP). Most of the neurological and ocular manifestations occur secondary to deficiency syndromes that is consequent to fat malabsorption from the small intestine. In this report, we have described the phenotype of a young adult female who manifested with recurrent diarrheal illness in her first decade, followed by anemia, RP, and neurological involvement with progressive deafness, cerebellar and sensory ataxia, and subclinical neuropathy in her second decade of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0972-2327.128574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992748PMC
January 2014
8 Reads

Spur cell anemia in end-stage liver disease: a zebra!

Am J Emerg Med 2014 Aug 25;32(8):944.e3-4. Epub 2014 Jan 25.

SUNY Upstate Medical University, Syracuse, NY 13210. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2014.01.027DOI Listing
August 2014
9 Reads

Spur cell anemia associated with alcoholic cirrhosis.

Intern Med 2013 ;52(24):2831

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Japan.

View Article

Download full-text PDF

Source
August 2014
6 Reads

Presence of spur cells as a highly predictive factor of mortality in patients with cirrhosis.

J Gastroenterol Hepatol 2014 Apr;29(4):830-4

2nd Department of Medicine, University of Athens Medical School, Hippokration General Hospital, Athens, Greece.

Background And Aim: The presence of spur-cell anemia (SCA) is due to lipid disturbances of the erythrocyte membrane and may develop in patients with advanced liver cirrhosis. The accurate predicting value of SC for survival has not been clarified. The aim of this study was to evaluate SCA as a prognostic indicator in patients with cirrhosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.12473DOI Listing
April 2014
8 Reads

Disease distribution in canine patients with acanthocytosis: 123 cases.

Vet Clin Pathol 2013 Dec;42(4):465-70

Department of Clinical Sciences, Animal Cancer Center, Colorado State University, Ft Collins, CO, USA.

Background: An acanthocyte is an abnormally shaped erythrocyte. In veterinary medicine, acanthocytes have historically been associated with canine hemangiosarcoma. In human medicine, acanthocytes are rarely observed with neoplastic disease and are more commonly associated with a variety of hereditary and acquired diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vcp.12097DOI Listing
December 2013
10 Reads

Hematologic manifestations of liver disease.

Authors:
Peter W Marks

Semin Hematol 2013 Jul;50(3):216-21

Center for Biologics Evaluation and Research, United States Food and Drug Administration, Rockville, MD 20852, USA.

The liver plays a key role in both protein biosynthesis and lipid metabolism. As a result, hepatic synthetic dysfunction can have adverse effects on both cellular and soluble components of blood. Anemia may occur due to the hemolysis of acanthocytes (spur cells), which is ultimately due to abnormal lipid composition of the red blood cell membrane. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminhematol.2013.06.003DOI Listing
July 2013
8 Reads

Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling.

Blood 2013 Jul 21;122(2):262-71. Epub 2013 May 21.

Cell Signalling Group, Laboratory for Cancer Medicine, Western Australian Institute for Medical Research and Centre for Medical Research, University of Western Australia, Perth, WA, Australia.

Lyn is involved in erythropoietin (Epo)-receptor signaling and erythroid homeostasis. Downstream pathways influenced following Lyn activation and their significance to erythropoiesis remain unclear. To address this, we assessed a gain-of-function Lyn mutation (Lyn(up/up)) on erythropoiesis and Epo receptor signaling. Read More

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/content/122/2/262.full.pdf
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-10-46
Publisher Site
http://dx.doi.org/10.1182/blood-2012-10-463158DOI Listing
July 2013
10 Reads

Transfusion medicine illustrated. Spur cell anemia associated with primary biliary cirrhosis.

Transfusion 2013 Feb;53(2):260

Service d'Hématologie Biologique, Centre Hospitalier Universitaire, Nancy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1537-2995.2012.03733.xDOI Listing
February 2013
5 Reads

Osteoresorptive arsenic intoxication.

Bone 2013 Apr 19;53(2):541-5. Epub 2013 Jan 19.

Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg General Hospital, Im Neuenheimer Feld 671, 69120 Heidelberg, Germany.

A 47-year-old woman consulted her dermatologist complaining whole body dermatitis, urticaria and irritating bullous eruptions on the plantar and side surfaces of her feet. She had had multiple hypopigmented spots on her skin since her early adulthood. The patient was treated with topical medication without significant improvement of symptoms. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282130003
Publisher Site
http://dx.doi.org/10.1016/j.bone.2013.01.017DOI Listing
April 2013
6 Reads

The cholesterol content of the erythrocyte membrane is an important determinant of phosphatidylserine exposure.

Biochim Biophys Acta 2012 Dec 31;1821(12):1493-500. Epub 2012 Aug 31.

Laboratory of Red Blood Cell Diagnostics, Dept. of Blood Cell Research, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.

Maintenance of the asymmetric distribution of phospholipids across the plasma membrane is a prerequisite for the survival of erythrocytes. Various stimuli have been shown to induce scrambling of phospholipids and thereby exposure of phosphatidylserine (PS). In two types of patients, both with aberrant plasma cholesterol levels, we observed an aberrant PS exposure in erythrocytes upon stimulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2012.08.008DOI Listing
December 2012
26 Reads

Reversibility of spur cell anemia.

Blood 2011 Oct;118(16):4304

University Hospital Zurich.

View Article

Download full-text PDF

Source
October 2011
6 Reads

Evaluation of Peripheral Blood Smear for Myelodysplasia in Breast Cancer Patients who Received Adjuvant Antracycline.

Eurasian J Med 2011 Dec;43(3):173-6

Department of Internal Medicine, Kayseri Education and Research Hospital, Kayseri, Turkey.

Objective: Therapy-related myeloid neoplasms (t-MN) account for approximately 10% to 20% of all cases of AML (acute myeloid leukemia), MDS (myelodysplastic syndrome) and MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasms), MDS, and MDS/MPN. In our study, we evaluated peripheral blood smear samples and hemogram values in breast cancer patients who were receiving adjuvant anthracycline regimens and were in remission.

Materials And Methods: A total of 78 patients receiving anthracycline-based adjuvant chemotherapy treatment from Kayseri Research and Training Hospital and Mersin State Hospital were enrolled in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/eajm.2011.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261399PMC
December 2011
5 Reads

Drug-induced hemolytic anemia and thrombocytopenia associated with alterations of cell membrane lipids and acanthocyte formation.

Toxicol Pathol 2010 Oct 30;38(6):907-22. Epub 2010 Aug 30.

Merck Research Laboratories, Lafayette, NJ 07848, USA.

CXCR3 is a chemokine receptor, upregulated upon activation of T cells and expressed on nearly 100% of T cells in sites of inflammation. SCH 900875 is a selective CXCR3 receptor antagonist. Thrombocytopenia and severe hemolytic anemia with acanthocytosis occurred in rats at doses of 75, 100, and 150 mg/kg/day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0192623310378865DOI Listing
October 2010
21 Reads

Spur cells and spur cell anemia in hospitalized patients with advanced liver disease: Incidence and correlation with disease severity and survival.

Hepatol Res 2010 Feb 11;40(2):161-70. Epub 2010 Jan 11.

Gastroenterology and Hepatology Division, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.

Aim: Spur cell anemia (SCA) is a form of acquired hemolytic anemia seen in patients with advanced cirrhosis and particularly in patients with alcoholic cirrhosis. The aim of the present study was to evaluate the incidence of spur cells and spur cell anemia in patients with advanced liver disease and to correlate the presence of spur cell anemia with survival.

Methods: During a 33-month period, all patients with advanced cirrhosis (Child-Pugh-Turcott score [CPT]>/=7] who were hospitalized in our department for various reasons were included in this study. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1872-034X.2009.00590.x
Publisher Site
http://dx.doi.org/10.1111/j.1872-034X.2009.00590.xDOI Listing
February 2010
14 Reads

Is iron overload in alcohol-related cirrhosis mediated by hepcidin?

World J Gastroenterol 2009 Dec;15(46):5864-6

Department of Gastroenterology, University Hospital Birmingham, Vincent Drive, Birmingham B15 2TH, UK.

In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver transplantation. We demonstrate a reciprocal relationship between serum or urinary hepcidin and serum ferritin, which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum ferritin. The ferritin level falls with increasing hepcidin production after transplantation. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791283PMC
December 2009
12 Reads

Beta-spectrinBari: a truncated beta-chain responsible for dominant hereditary spherocytosis.

Haematologica 2009 Dec 16;94(12):1753-7. Epub 2009 Jul 16.

Department of Pediatrics, Second University of Naples, Naples, Italy.

We describe a beta-spectrin variant, named beta-spectrin Bari, characterized by a truncated chain and associated with hereditary spherocytosis. The clinical phenotype consists of a moderately severe hemolytic anemia, splenomegaly, and spherocytes and acanthocytes in the blood smear. The occurrence of the truncated protein, that represents about 8% of the total beta-spectrin occurring on the membrane, results in a marked spectrin deficiency. Read More

View Article

Download full-text PDF

Source
http://www.haematologica.org/cgi/doi/10.3324/haematol.2009.0
Publisher Site
http://dx.doi.org/10.3324/haematol.2009.010124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791944PMC
December 2009
11 Reads

Education and imaging. Hepatobiliary and pancreatic: spur cell anemia associated with alcoholic cirrhosis.

J Gastroenterol Hepatol 2008 Sep;23(9):1463

Department of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1440-1746.2008.05589.xDOI Listing
September 2008
7 Reads

Spur cell anemia associated with a cirrhotic non-alcoholic steatohepatitis patient.

Hepatol Res 2007 Jun;37(6):482-5

Department of Medicine and Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan.

Spur cell anemia is an acquired hemolytic anemia, which may occur in patients with severe liver dysfunction, especially in those with alcoholic cirrhosis. Recently, non-alcoholic steatohepatitis (NASH) has been highlighted as one of the causes of chronic liver diseases, which could progress to cirrhosis. Histological features of NASH are indistinguishable from those of alcoholic hepatitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1872-034X.2007.00037.xDOI Listing
June 2007
9 Reads

Acute hemolytic anemia with acanthocytosis associated with high-dose misoprostol for medical abortion.

Ann Emerg Med 2007 Sep 3;50(3):289-91. Epub 2006 Nov 3.

Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy.

We report a case of acute hemolytic anemia in a 21-year-old Nigerian woman after high-dose misoprostol (4 mg), used for medical abortion. The major causes of inherited or immune hemolytic anemia were excluded. The patient's peripheral blood smear showed acanthocytes and anisopoikilocytosis, which progressively disappeared in the days postingestion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annemergmed.2006.09.001DOI Listing
September 2007
5 Reads

Severe prolongation of the INR in spur cell anemia of cirrhosis: true-true and related?

Dig Dis Sci 2006 Jul;51(7):1203-5

Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, Virginia 22908-0708, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-006-8033-8DOI Listing
July 2006
9 Reads

Identification of two new members, XPLAC and XTES, of the XK family.

Gene 2006 Mar 20;370:6-16. Epub 2006 Jan 20.

The Lindsley F. Kimball Research Institute of the New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.

XK, a putative membrane transporter, is a component of the XK/Kell complex of the Kell blood group system. XK's substrate is unknown but absence of the protein, as occurs in the McLeod phenotype, is associated with red cell acanthocytosis and late onset central nervous system and neuromuscular abnormalities known as the McLeod syndrome. We have cloned two cDNAs, XPLAC (GenBank accession no. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2005.10.037DOI Listing
March 2006
7 Reads

Spur-cell anaemia in a patient with cirrhosis.

J Hepatol 2004 Jul;41(1):167

Liver Unit, Institut de Malalties Digestives, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2004.01.025DOI Listing
July 2004
7 Reads

A basis of the acanthocytosis in inherited and acquired disorders.

Authors:
P Wong

Med Hypotheses 2004 ;62(6):966-9

Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Que., Canada H2W 1S6.

Acanthocytosis refers to the transformation of the normal biconcave disc erythrocyte into one with a few irregularly shaped external projections distributed unevenly at its membrane surface. It is associated with a variety of inherited and acquired disorders. A relationship between the acanthocytosis in chorea-acanthocytosis and an alteration of Band 3, the anion exchange protein, has been previously suggested. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2003.12.032DOI Listing
December 2004
4 Reads

[Infantil hepatitis syndrome combined with spur cell anemia: a case report].

Zhonghua Er Ke Za Zhi 2003 May;41(5):379

View Article

Download full-text PDF

Source
May 2003
7 Reads

Spur cell anemia in alcoholic cirrhosis: cure by orthotopic liver transplantation and recurrence after liver graft failure.

Int Surg 2002 Oct-Dec;87(4):201-4

Department of Medicine, Sturgis Hospital, Sturgis, Michigan, USA.

Spur cell anemia is an acquired form of hemolytic anemia caused by a structural abnormality of red cell membranes that results in spiculated erythrocytes. These peculiarly shaped red blood cells, called acanthocytes, have a shortened survival and undergo splenic sequestration and destruction. Spur cell anemia has been known to occur in several conditions, including chronic liver disease, and more specifically in alcoholic cirrhosis. Read More

View Article

Download full-text PDF

Source
August 2003
11 Reads

Assessment of splenic functions in patients with hepato-splenic schistosomiasis using non-invasive techniques.

J Egypt Soc Parasitol 1999 ;29(1):203-13

Department of Surgery, Faculty of Medicine, Ain-Shams University, Cairo 11566, Egypt.

This study was carried out on forty cases, classified into 3 groups; group I: 10 healthy controls subjects, group II: 20 patients with hepatosplenic schistosomiasis and group III: 10 bilharzial patients who underwent total splenectomy. All cases were subjected to clinical examination, abdominal ultrasonography, rectal snips and laboratory investigations which included: stool and urine analysis, complete blood picture, IHAT for bilharziasis, liver function tests, viral markers, estimaton of T-lymphocyte subpopulations (CD(+)3, CD(+)4, & CD(+)8) by flow Cytometry, silver stained blood films to detect argyrophilic inclusions and 99mTc sulphur colloid splenic scan which was applied to group II only. The present results revealed varying degrees of hypersplenism (anaemia, leukopenia & thrombocytopenia) in GII. Read More

View Article

Download full-text PDF

Source
February 2003
5 Reads

Abetalipoproteinemia-like lipid profile and acanthocytosis in a young woman with anorexia nervosa.

Am J Med Sci 2002 Nov;324(5):281-4

Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

We report the case of a 17-year-old woman with anorexia nervosa (AN) who developed an abetalipoproteinemia-like lipid profile and acanthocytosis. These abnormalities resolved slowly as her nutritional status improved. We considered 3 possible causes of an abetalipoproteinemia-like lipid profile in AN: (1) depletion of hepatic substrate for apolipoprotein B synthesis, (2) lack of exogenous fatty acids with exhaustion of endogenous stores of triglycerides in adipose tissue, and (3) preservation of the lipoprotein lipase (LPL) mass. Read More

View Article

Download full-text PDF

Source
November 2002
6 Reads

beta-Spectrin São PauloII, a novel frameshift mutation of the beta-spectrin gene associated with hereditary spherocytosis and instability of the mutant mRNA.

Braz J Med Biol Res 2002 Aug;35(8):921-5

Hemocentro, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Hereditary spherocytosis (HS) is a common inherited anemia characterized by the presence of spherocytic red cells. Defects in several membrane protein genes have been involved in the pathogenesis of HS. beta-Spectrin-related HS seems to be common. Read More

View Article

Download full-text PDF

Source
August 2002
4 Reads

Human erythroid cells are affected by aluminium. Alteration of membrane band 3 protein.

Biochim Biophys Acta 2002 Feb;1558(2):142-50

Laboratorio de Análisis Biológicos, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Piso 4. Ciudad Universitaria, 1428 Buenos Aires, Argentina.

There is evidence that anaemia is associated with aluminium (Al). We have already reported on the sensitivity to Al, showed by erythroid cell populations of animals chronically exposed to the metal. In order to investigate whether Al could also affect human cells, experiments were carried out both on immature and mature human erythroid cells. Read More

View Article

Download full-text PDF

Source
February 2002
7 Reads

Abetalipoproteinemia: a case report.

Turk J Pediatr 2001 Jul-Sep;43(3):243-5

Department of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Abetalipoproteinemia is a rare autosomal recessive disorder characterized by steatorrhea, poor weight gain, acanthocytosis and retinitis pigmentosa. Here we peresent a six-month-old patient with abetaliporoteinemia. He had a history of chronic diarrhea from the first month of life. Read More

View Article

Download full-text PDF

Source
November 2001
6 Reads

Successful combination therapy--flunarizine, pentoxifylline, and cholestyramine--for spur cell anemia.

Int J Hematol 2001 Apr;73(3):351-5

First Department of Internal Medicine, University of Tokushima School of Medicine, Japan.

Spur cell anemia, a hemolytic anemia observed in patients with alcoholic cirrhosis, is characterized by unusual erythrocyte morphology and an increased ratio of free cholesterol to phospholipid in the erythrocyte membrane. The prognosis of spur cell anemia is usually extremely poor, however, we describe here a patient with spur cell anemia who was successfully treated with combination therapy consisting of flunarizine, pentoxifylline, and cholestyramine. Initial therapy with flunarizine alone for 6 weeks did not significantly decrease the number of spur cells on peripheral blood smears. Read More

View Article

Download full-text PDF

Source
April 2001
3 Reads

Spur cell anaemia and acute haemolysis in patients with hyperreactive malarious splenomegaly. Experience in an isolated Yanomamo population of Venezuela.

Acta Trop 2000 Dec;77(3):257-62

Infectious Diseases Section, Tropical Medicine Institute, Universidad Central de Venezuela, 'Dr Felix Pifano C', Apartado 47019, 1041-A, Caracas, Venezuela.

A prospective study, aimed to investigate the aetiology of an unusual clustering of cases of severe acute haemolytic anaemia affecting a high percentage of the adult population, was carried out in two isolated Yanomamo communities of the Upper Orinoco basin in Venezuela. Twenty-six patients with active or recent episodes of severe haemolysis were evaluated. All of them exhibited massive liver and spleen enlargement and fulfilled the diagnostic criteria of the hyperreactive malarious splenomegaly (HMS) syndrome. Read More

View Article

Download full-text PDF

Source
December 2000
4 Reads