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Morphologie 2022 May 20. Epub 2022 May 20.

Service d'hématologie biologique, centre hospitalier universitaire, Nancy, France.

Here is reported the case of an adult patient with ethylic cirrhosis associated with spur cell anemia. Moreover, acute vacuolation of leukocytes was observed in relationship with recent binge drinking. Read More

N Engl J Med 2022 Jan;386(4):e6

Vanderbilt University Medical Center, Nashville, TN

Am J Vet Res 2021 Dec 21;83(3):198-204. Epub 2021 Dec 21.

Unité de Biochimie et Biologie Clinique/Laboratoire BioPôle, École Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, France.

Objective: To document RBC abnormalities in dogs with congenital ventricular outflow tract obstruction.

Animals: 62 dogs with pulmonic stenosis (PS) or aortic stenosis (AS) and 20 control dogs were recruited.

Procedures: The proportions of RBCs that were schistocytes, acanthocytes, and keratocytes were assessed. Read More

PLoS One 2021 27;16(10):e0257796. Epub 2021 Oct 27.

Manatt Health Strategies, Washington, DC, United States of America.

Sickle cell disease is a progressively debilitating genetic condition that affects red blood cells and can result in a variety of serious medical complications, reduced life expectancy, and diminished quality of life. Medicaid nationwide covered 66 percent of sickle cell disease hospitalizations in 2004 and 58 percent of emergency department visits for the disease between 1999 and 2007. Using Medicaid data from four states with large populations that account for more than one-third of Medicaid program enrollment, we examined the characteristics of those with sickle cell disease. Read More

Blood Adv 2021 10;5(19):3855-3861

Consultant, New York, NY.

More than 20 years ago, clinical trials and federal grant support for sickle cell disease (SCD) research were not on par with support for other genetic diseases. Faced with the opportunity to spur research and advance treatments for SCD, and at the recommendation of advisors, the Doris Duke Charitable Foundation (DDCF) offered an SCD research funding opportunity starting in 2009 through its Innovations in Clinical Research Awards (ICRA) program. Twenty-eight new grants of $450 000 for direct costs over 3 years and 7 renewals were awarded, for a total investment of $17 million. Read More

Am J Hematol 2021 12 7;96(12):1611-1620. Epub 2021 Oct 7.

Harvard Medical School, Boston, Massachusetts, USA.

Spur cell hemolytic anemia (SCHA) is a rare, acquired, nonimmune hemolytic anemia of decompensated cirrhosis. Data describing prognostic impact, outcomes of liver transplant, and clinical hematologic characteristics of SCHA are absent or limited. We performed a multicenter, 24-year observational cohort study of patients with SCHA, retrospectively analyzing hepatic and hematologic parameters, independent predictors of mortality, and long-term outcomes of liver transplant. Read More

Blood 2021 07;138(3):283

Houston Methodist Hospital.

Case Rep Hematol 2021 26;2021:8883335. Epub 2021 Mar 26.

Department of Medicine, Division of Hematology, University of Miami, Miami, FL, USA.

The etiology of anemia in liver cirrhosis is multifactorial; one less recognized cause is hemolytic anemia due to spur cells, known as spur cell anemia. We present the case of a 57-year-old woman with alcoholic cirrhosis who presented with symptomatic macrocytic anemia with a hemoglobin level of 7.4 g/dL and signs of decompensated liver disease. Read More

Mov Disord Clin Pract 2021 Feb 29;8(2):193-207. Epub 2020 Dec 29.

Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA.

Background: Movement disorders can be associated with or caused by hematological abnormalities. The objective of this review is to highlight features that will aid in the clinician's recognition and treatment of these disorders.

Methods: MESH terms relevant to movement disorders and hematologic diseases were searched to identify conditions included in this narrative, educational review. Read More

BMC Infect Dis 2021 Jan 28;21(1):121. Epub 2021 Jan 28.

Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany.

Background: Prolonged myelosuppression following CD19-directed CAR T-cell transfusion represents an important, yet underreported, adverse event. The resulting neutropenia and multifactorial immunosuppression can facilitate severe infectious complications.

Case Presentation: We describe the clinical course of a 59-year-old patient with relapsed/refractory DLBCL who received Axicabtagene-Ciloleucel (Axi-cel). Read More

Cleve Clin J Med 2020 11 2;87(11):649-650. Epub 2020 Nov 2.

James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY.

Cureus 2020 Sep 21;12(9):e10568. Epub 2020 Sep 21.

Gastroenterology, All India Institute of Medical Sciences, Patna, IND.

Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of chronic liver disease associated with organ failures. Anemia of diverse etiology is common in patients with ACLF. Spur cell anemia (SCA) is a form of acquired hemolytic anemia that occurs rarely in such patients due to dysregulated lipids metabolism. Read More

J Microsc 2020 12 17;280(3):287-296. Epub 2020 Sep 17.

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.

In physiological conditions, red blood cells (RBCs) are capable of dramatic deformations when passing through the microvasculature. This extreme deformability is closely related to the RBC biconcave shape, to the fluidic nature of the haemoglobin and the cell membrane structure, primarily consisting of a phospholipid bilayer with an underlying two-dimensional spectrin network. In many pathological and inflammatory conditions, the shape and the extreme deformability of erythrocytes appear to be significantly altered. Read More

Clin J Gastroenterol 2020 Oct 29;13(5):882-890. Epub 2020 May 29.

Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.

Spur cell anemia is an acquired hemolytic anemia associated with liver cirrhosis and is characterized by the presence of increased large red blood cells, which are covered with spike-like projections that vary in width, length, and distribution. A 26-year-old man was referred to our hospital presenting with jaundice, lower limb edema, and dyspnea. The patient was subsequently diagnosed with spur cell anemia related to alcoholic liver cirrhosis. Read More

J Biomed Opt 2020 01;25(1):1-13

City Univ. of Hong Kong, China.

Abnormally shaped red blood cells (RBCs), called poikilocytes, can cause anemia. At present, the biochemical abnormalities in poikilocytes are not well understood. Normal RBCs and poikilocytes were analyzed using whole-blood and single-cell methods. Read More

Rev Med Liege 2019 Oct;74(10):527-534

Service de Gastro-Entérologie et Hépatologie, CHU Liège, Belgique.

We report here the case of a 62-year-old patient with Child-Pugh stage C ethylic cirrhosis associated with severe macrocytic anaemia, refractory to iterative transfusions and withdrawal. After a haemorrhagic, deficiency-related, or sideroblastic etiology was ruled out, haemolytic anaemia was suspected. A blood smear allowed diagnosis of haemolytic anaemia with acanthocytes. Read More

Case Rep Hematol 2019 12;2019:3146965. Epub 2019 Feb 12.

Houston Methodist Hospital, Department of Medicine, 6550 Fannin St, Houston, TX 77030, USA.

Autosplenectomy (AS) is a known complication of diseases such as sickle cell anemia, celiac disease, and inflammatory bowel disease. We report the first known case of AS due to paroxysmal nocturnal hemoglobinuria (PNH). A 24-year-old Caucasian male had evidence of hemolytic anemia at the age of 14 and was diagnosed with PNH at the age of 16. Read More

N Engl J Med 2018 Aug;379(8):774

Oregon Health and Science University, Portland, OR

Case Rep Hematol 2018 21;2018:9513946. Epub 2018 Jun 21.

Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, Japan.

Background: Spur cell anemia (SCA) is a cause of hemolytic anemia in patients with alcoholic liver cirrhosis. Because dyslipidemia is related to the development of spur cells, SCA was previously treated with plasmapheresis.

Case Report: A 52-year-old Japanese man with SCA associated with alcoholic liver cirrhosis (Child-Pugh C) underwent two rounds of plasmapheresis. Read More

BMJ Case Rep 2018 Jan 31;2018. Epub 2018 Jan 31.

Medical Oncology/Medicine, Captain James A. Lovell Federal Health Care Center, North Chicago, Illinois, USA.

Spur cell haemolytic anaemia (SCA) is a form of anaemia that can be seen in patients with severely impaired liver function or advanced cirrhosis. It is associated with high mortality. The treatment options for SCA secondary to cirrhosis are limited. Read More

Dig Dis Sci 2018 Jan 25;63(1):16-26. Epub 2017 Nov 25.

Department of Clinical and Experimental Medicine, Garibaldi Hospital, University of Catania, Via Palermo, 636, 95122, Catania, Italy.

Progressive lipoprotein impairment occurs in liver cirrhosis and is associated with increased morbidity and mortality. The present review aims to summarize the current evidence regarding the prognostic value of lipoprotein abnormalities in liver cirrhosis and to address the need of a better prognostic stratification of patients, including lipoprotein profile assessment. Low levels of lipoproteins are usual in cirrhosis. Read More

Blood 2017 12 6;130(25):2786-2798. Epub 2017 Nov 6.

Institute for Pathophysiology, West German Heart and Vascular Center and.

The hepatocyte nuclear factor (HNF) family regulates complex networks of metabolism and organ development. Human mutations in its prototypical member HNF1A cause maturity-onset diabetes of the young (MODY) type 3. In this study, we identified an important role for HNF1A in the preservation of erythrocyte membrane integrity, calcium homeostasis, and osmotic resistance through an as-yet unrecognized link of HNF1A to sphingolipid homeostasis. Read More

Clin Chim Acta 2017 May 20;468:81-84. Epub 2017 Feb 20.

Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

Introduction: Inherited anemias diagnostic workup requires a step-wise algorithm. Causal genes implicated in congenital hemolytic anemia are numerous, making a gene-by-gene approach by Sanger sequencing time consuming, expensive and labour intensive. Targeted resequencing can be of great use in explaining these cases. Read More

Med Clin North Am 2017 Mar 10;101(2):417-429. Epub 2016 Dec 10.

Division of Hematology/Medical Oncology, Department of Medicine, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201-3098, USA; Division of Hematology/Medical Oncology, Department of Medicine, Knight Cancer Institute, Oregon Health and Science University, MC L586, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:

Many processes lead to anemia. This review covers anemias that are less commonly encountered in the United States. These anemias include hemoglobin defects like thalassemia, bone marrow failure syndromes like aplastic anemia and pure red cell aplasia, and hemolytic processes such as paroxysmal nocturnal hemoglobinuria. Read More

Int J Lab Hematol 2017 Jun 22;39(3):e64-e65. Epub 2016 Dec 22.

Department of Pediatrics, UCMS and GTB Hospital, New Delhi, India.

Gastroenterol Hepatol Bed Bench 2016 ;9(4):335-339

Department of Clinical and Experimental Medicine, Garibaldi Hospital, University of Catania, Italy.

Chronic anemia is common in liver cirrhosis. In this setting, the pathogenesis of anemia is complex and multifactorial. Spur cell anemia is a serious disorder in cirrhotic patients and is associated with poor prognosis. Read More

Transfusion 2016 Apr;56(4):787-8

University of Washington, Harborview Medical Center, Seattle, Washington.

Am J Hematol 2016 Oct 22;91(10):1061. Epub 2016 Mar 22.

Division of Hematology, Mayo Clinic, Rochester, Minnesota.

Rev Clin Esp (Barc) 2016 May 5;216(4):233. Epub 2015 Dec 5.

Servicio de Hematología, Hospital Universitario de Móstoles, Móstoles, Madrid, España.