1,485 results match your criteria Sprue Tropical


[Tropical sprue: report of a case].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):802-803

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.019DOI Listing
October 2018

Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review.

J Gastroenterol Hepatol 2019 Jan 30;34(1):74-83. Epub 2018 Aug 30.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background And Aim: While the prevalence of celiac disease (CD) is increasing globally, the prevalence of tropical sprue (TS) is declining. Still, there are certain regions in the world where both patients with CD and TS exist and differentiation between them is a challenging task. We conducted a systematic review of the literature to find out differentiating clinical, endoscopic, and histological characteristics between CD and TS. Read More

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http://dx.doi.org/10.1111/jgh.14403DOI Listing
January 2019
4 Reads
3.504 Impact Factor

Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial.

Trials 2017 Nov 6;18(1):523. Epub 2017 Nov 6.

Department of Pediatrics, Washington University in St. Louis, One Children's Place, Campus Box 8116, Saint Louis, MO, 63110, USA.

Background: Chronic childhood malnutrition, as manifested by stunted linear growth, remains a persistent barrier to optimal child growth and societal development. Environmental enteric dysfunction (EED) is a significant underlying factor in the causal pathway to stunting, delayed cognitive development, and ultimately morbidity and mortality. Effective therapies against EED and stunting are lacking and further clinical trials are warranted to effectively identify and operationalize interventions. Read More

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http://dx.doi.org/10.1186/s13063-017-2278-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674751PMC
November 2017
9 Reads

Practical Approach to the Flattened Duodenal Biopsy.

Authors:
Thomas C Smyrk

Surg Pathol Clin 2017 Dec 23;10(4):823-839. Epub 2017 Sep 23.

Department of Pathology, Mayo Clinic, Hilton 11, 200 First Street Southwest, Rochester, MN 55902, USA. Electronic address:

Celiac disease features duodenal intraepithelial lymphocytosis with or without villous atrophy. Lymphocytosis without villous atrophy will be proven to represent celiac disease in 10% to 20% of cases. The differential diagnosis is broad: Helicobacter pylori gastritis, NSAID injury and bacterial overgrowth are considerations. Read More

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http://dx.doi.org/10.1016/j.path.2017.07.004DOI Listing
December 2017
7 Reads

Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review.

World J Gastroenterol 2017 Oct;23(37):6788-6801

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder, common in clinic and in the community. It has a significant impact on both society and patients' quality of life. The epidemiology, clinical presentation, and management of IBS may vary in different geographical regions due to differences in diet, gastrointestinal infection, socio-cultural and psycho-social factors, religious and illness beliefs, symptom perception and reporting. Read More

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http://dx.doi.org/10.3748/wjg.v23.i37.6788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645613PMC
October 2017
1 Read

Pros and Cons While Looking Through an Asian Window on the Rome IV Criteria for Irritable Bowel Syndrome: Pros.

Authors:
Uday C Ghoshal

J Neurogastroenterol Motil 2017 Jul;23(3):334-340

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

A decade after Rome III, in 2016, Rome IV criteria were published. There are major differences between Rome IV and the earlier iteration, some of which are in line with Asian viewpoints. The clinical applicability of the Rome IV criteria of irritable bowel syndrome (IBS) in Asian perspective is reviewed here. Read More

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http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm1
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http://dx.doi.org/10.5056/jnm17020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503282PMC
July 2017
7 Reads

Tropical Enteropathies.

Curr Gastroenterol Rep 2017 Jul;19(7):29

Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, Newark Street, London, E1 2AT, UK.

Purpose Of Review: The term 'tropical enteropathy' originated in observations in the 1960s that small intestinal morphology and function differed in the tropics from the norms found in temperate climates. It was subsequently shown that this enteropathy is more closely related to environmental conditions than latitude, and it was re-labelled 'environmental enteropathy'. It is now recognised that environmental enteropathy (also now called environmental enteric dysfunction) has implications for the health and linear growth of children in low- and middle-income countries, and it may underlie poor responses to oral vaccination in these countries. Read More

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http://dx.doi.org/10.1007/s11894-017-0570-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443857PMC
July 2017
11 Reads

Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link.

Nat Rev Gastroenterol Hepatol 2017 Jul 17;14(7):435-441. Epub 2017 May 17.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 6A Napier Road, Singapore, 258500.

Evidence is emerging that IBS, a hitherto enigmatic disorder thought to be predominantly related to psychological factors, has a microorganic basis in a subset of patients with the disease. Post-infectious IBS (PI-IBS), commonly of the diarrhoea-predominant subtype (defined as new development of IBS following acute infectious diarrhoea), is one such condition known to occur in up to 10-30% individuals after acute gastroenteritis. However, following acute infectious gastroenteritis, patients can also develop post-infectious malabsorption syndrome (PI-MAS), popularly known as tropical sprue. Read More

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http://dx.doi.org/10.1038/nrgastro.2017.37DOI Listing
July 2017
31 Reads

Small Intestinal Bacterial Overgrowth and Other Intestinal Disorders.

Gastroenterol Clin North Am 2017 03;46(1):103-120

Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.

Gut microbiota is the largest organ of the human body. Although growth of bacteria more than 10 colony forming unit (CFU) per milliliter in culture of upper gut aspirate is used to diagnosis small intestinal bacterial overgrowth (SIBO), 10 CFU or more is being considered to suggest the diagnosis, particularly if colonic type bacteria are present in the upper gut. Although neither very sensitive nor specific, hydrogen breath tests are widely used to diagnose SIBO. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553163008
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http://dx.doi.org/10.1016/j.gtc.2016.09.008DOI Listing
March 2017
3 Reads

A Surprising Case of Acute Diarrhea in the South of France.

Gastroenterology 2017 Jan 26;152(1):e1-e3. Epub 2016 Nov 26.

Département d'Hépatogastroenterologie et Transplantation, CHU Saint Eloi, Université de Montpellier, Montpellier, France.

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http://dx.doi.org/10.1053/j.gastro.2016.07.015DOI Listing
January 2017
5 Reads
16.720 Impact Factor

Nonalcoholic steatohepatitis heralding olmesartan-induced sprue-like enteropathy.

Dig Liver Dis 2016 Nov 15;48(11):1399-1401. Epub 2016 Jul 15.

Outpatient Liver Clinic and Operating Unit of Internal Medicine, Azienda USL di Modena, NOCSAE, Modena, Italy.

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http://dx.doi.org/10.1016/j.dld.2016.07.004DOI Listing
November 2016
7 Reads

Immunohistochemical Expression of Antitissue Transglutaminase 2 in Tissue Injuries: An Interpretation Beyond Celiac Disease.

Appl Immunohistochem Mol Morphol 2018 Jul;26(6):425-430

Departments of Gastroenterology and Human Nutrition, Pathology, and Nephrology, All India Institute of Medical Sciences, New Delhi, India.

Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement in CeD, tissue blocks of patients with IgA nephropathies (IgAN), minimal change disease, membranous glomerulonephritis, membrano-proliferative glomerulonephritis, normal kidney, intestinal biopsies from CeD, tropical sprue, nonspecific duodenitis, and inflammatory bowel disease; liver biopsies from patients with chronic hepatitis B and C, acute liver failure (ALF), and CeD-associated liver diseases were retrieved and subjected to IHC staining for anti-tissue transglutaminase 2 enzyme. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000430DOI Listing
July 2018
16 Reads
1 Citation

The maladies of malabsorption.

J Pediatr Neurosci 2016 Jan-Mar;11(1):74-6

Surgical Gastroenterology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Malabsorption syndrome (MAS) is a common condition in India. In Indian adults, tropical sprue and celiac disease are leading causes of MAS. Sometimes, the diagnosis of MAS may pose a challenge due to the varied signs and symptoms. Read More

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http://dx.doi.org/10.4103/1817-1745.181266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862297PMC
May 2016
5 Reads

Olmesartan-associated sprue-like enteropathy: a systematic review with emphasis on histopathology.

Hum Pathol 2016 Apr 19;50:127-34. Epub 2015 Dec 19.

Department of Pathology and Cell Biology, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY 10032. Electronic address:

Sprue-like enteropathy associated with the angiotensin II receptor blocker (ARB) olmesartan was first described in 2012, and a number of cases have since been reported. This syndrome is characterized by severe diarrhea and sprue-like histopathologic findings in the intestine, often with increased subepithelial collagen. The incidence of this adverse drug reaction is not entirely clear, although it is thought to be rare. Read More

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http://dx.doi.org/10.1016/j.humpath.2015.12.001DOI Listing
April 2016
10 Reads

Spectrum of chronic small bowel diarrhea with malabsorption in Indian subcontinent: is the trend really changing?

Intest Res 2016 Jan 26;14(1):75-82. Epub 2016 Jan 26.

Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India.

Background/aims: This study aimed to document the recent etiological spectrum of chronic diarrhea with malabsorption and also to compare features that differentiate tropical sprue from parasitic infections, the two most common etiologies of malabsorption in the tropics.

Methods: We analyzed 203 consecutive patients with malabsorption. The etiological spectrum and factors that differentiated tropical sprue from parasitic infections were analyzed. Read More

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http://dx.doi.org/10.5217/ir.2016.14.1.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754526PMC
January 2016
7 Reads

Disorders associated with malabsorption of iron: A critical review.

Pak J Med Sci 2015 Nov-Dec;31(6):1549-53

Khansa Qamar, M.Phil. (Hematology). Baqai Institute of Hematology, Baqai Medical University, Karachi, Pakistan.

Malabsorption is a disorder of the gastrointestinal tract that leads to defective digestion, absorption and transport of important nutrients across the intestinal wall. Small intestine is the major site where most of the nutrients are absorbed. There are three main mechanisms of malabsorption; premucosal, mucosal and postmucosal. Read More

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http://dx.doi.org/10.12669/pjms.316.8125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744319PMC
February 2016
2 Reads

Prevalence and Characteristics of Duodenal Villous Atrophy in Renal Transplant Patients Presenting With Persistent Diarrhea in a Developing Country.

Exp Clin Transplant 2016 Apr 23;14(2):146-52. Epub 2015 Oct 23.

From the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Objectives: Persistent diarrhea is a common complication after solid-organ transplant, including kidney transplant. Data on duodenal villous atrophy as a cause of persistent diarrhea in renal transplant recipients are scarce.

Materials And Methods: We conducted a prospective analysis of 207 patients who received renal transplants from 2009 to 2012 with persistent diarrhea and who underwent upper gastrointestinal endoscopy and duodenal biopsies. Read More

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http://dx.doi.org/10.6002/ect.2015.0183DOI Listing
April 2016
7 Reads
0.800 Impact Factor

Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study.

Dig Dis Sci 2015 Nov 27;60(11):3379-85. Epub 2015 Jun 27.

Enteric Disease Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

Background: Previous studies have linked an increase in functional and pathological gastrointestinal (GI) disorders following antecedent infectious gastroenteritis (IGE), yet studies of other chronic GI disorders such as tropical sprue (TS) and intestinal malabsorption (IM) are lacking. This study was performed to evaluate the association between documented IGE and the risk of TS and IM using a matched case-control study.

Methods: The odds of IGE (exposure) among subjects with TS and IM were compared to the odds of exposure in matched controls. Read More

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http://link.springer.com/10.1007/s10620-015-3768-8
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http://dx.doi.org/10.1007/s10620-015-3768-8DOI Listing
November 2015
10 Reads

Early, non-refractory celiac disease associated with microscopic colitis and splenomegaly.

J Coll Physicians Surg Pak 2015 Apr;25 Suppl 1:S14-6

Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi-74200.

Celiac Disease (CD), also known as non-Tropical sprue, and Celiac sprue is an immune-mediated disorder, triggered by gluten containing grains in genetically susceptible people. The disease may be diagnosed at any age and can affect many organ systems. Its diagnosis and management can often be challenging. Read More

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http://dx.doi.org/04.2015/JCPSP.S14S16DOI Listing
April 2015
17 Reads
0.320 Impact Factor

[Rare diseases on the trail--the registry for refractory sprue].

Z Gastroenterol 2015 Feb;53(2):136

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February 2015
1 Read

Gastrointestinal complications in renal transplant recipients detected by endoscopic biopsies in a developing country.

Indian J Gastroenterol 2015 Jan 12;34(1):51-7. Epub 2015 Mar 12.

Javed I. Kazi Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Background: Renal transplantation is the treatment of choice for patients with end-stage renal disease. The renal transplant recipients are susceptible to a variety of gastrointestinal (GI) complications such as infections, ulcer disease, and malignancies.

Objectives: We aimed to determine the frequency of pathological lesions in GI endoscopic biopsies in recipients of live related renal transplantation in our setting. Read More

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http://link.springer.com/10.1007/s12664-015-0537-8
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http://dx.doi.org/10.1007/s12664-015-0537-8DOI Listing
January 2015
4 Reads

Chronic infections of the small intestine.

Curr Opin Gastroenterol 2015 Mar;31(2):104-10

aNational Centre for Paediatric Gastroenterology, Our Lady's Children's Hospital bNational Children's Research Centre, Crumlin, Dublin cUCD School of Medicine and Medical Science dConway Institute, University College Dublin, Belfield, Dublin, Ireland.

Purpose Of Review: Chronic infections of the small intestine cause significant morbidity and mortality globally. This review focuses on the recent advances in the field of our understanding of selected intestinal infections.

Recent Findings: Primary and secondary immunodeficiency increase the susceptibility to many chronic intestinal infections. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000153DOI Listing
March 2015
6 Reads
4.290 Impact Factor

The biopsy pathology of non-coeliac enteropathy.

Authors:
Joel K Greenson

Histopathology 2015 Jan;66(1):29-36

University of Michigan Medical Center, Ann Arbor, MI, USA.

Tropical sprue (TS) is a malabsorption syndrome of presumed infectious aetiology that affects residents of (or visitors to) the tropics. The histological changes of TS are similar to those of coeliac disease, with increased intraepithelial lymphocytes being central to both. Unlike in coeliac disease, however, a completely flat small bowel biopsy is uncommon in TS. Read More

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http://dx.doi.org/10.1111/his.12522DOI Listing
January 2015
3 Reads

Pathology of celiac disease: a brief review.

Authors:
S Datta Gupta

Trop Gastroenterol 2013 Oct-Dec;34(4):207-26

Celiac disease is a gluten or prolamine-induced immunological disorder primarily affecting the intestines. Celiac disease is often missed since not only are clinical findings 'not typical' but also because many cases are asymptomatic. The diagnosis is based on a constellation of clinical, serological and histological findings in a duodenal biopsy, in addition to HLA genotype. Read More

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August 2014
18 Reads

Distinguishing tropical sprue from celiac disease in returning travellers with chronic diarrhoea: a diagnostic challenge?

Travel Med Infect Dis 2014 Jul-Aug;12(4):401-5. Epub 2014 May 16.

Institute for Tropical Diseases, Department of Internal Medicine, Harbour Hospital Rotterdam, Haringvliet 2, 3011 TD Rotterdam, The Netherlands; Travel Clinic Havenziekenhuis, Haringvliet 72, 3011 TD Rotterdam, The Netherlands. Electronic address:

Background: Within the present era of worldwide travel, it is important for all clinicians to consider the possibility of tropical sprue (TS) in returning patients with persistent diarrhoea after travel. The symptoms and histologic findings of TS can resemble but also be confused with celiac disease (CD).

Material And Method: Patients at our institute diagnosed with CD or TS in the period January 2000-December 2010 were eligible for inclusion. Read More

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http://dx.doi.org/10.1016/j.tmaid.2014.05.001DOI Listing
March 2015
8 Reads

Neil Hamilton Fairley KBE FRCP FRS (1891-1966): an outstanding tropical physician in the twentieth century.

Authors:
G C Cook

J Med Biogr 2014 Nov 15;22(4):215-20. Epub 2014 May 15.

University College London, UK.

In the late nineteenth and early twentieth centuries, British physicians led the way in tropical medicine research. Several years later scientific advances had slowed, and Fairley's numerous contributions were thus most welcome. Neil Hamilton Fairley was born of Scottish parents at Victoria, Australia. Read More

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http://journals.sagepub.com/doi/10.1177/0967772013479534
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http://dx.doi.org/10.1177/0967772013479534DOI Listing
November 2014
3 Reads

Tropical sprue in 2014: the new face of an old disease.

Curr Gastroenterol Rep 2014 ;16(6):391

Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, India,

Tropical sprue (TS), once known to be a common cause of malabsorption syndrome (MAS) in India and other tropical countries, is believed to be uncommon currently in spite of contrary evidence. Several recent studies from India showed TS to be the commonest cause of sporadic MAS in Indian adults. TS is diagnosed in patients presenting with suggestive clinical presentation, which cannot be explained by another cause of MAS and investigations revealing malabsorption of two unrelated substances, abnormal small-intestinal mucosal histology, which responds to treatment with antibiotics such as tetracycline and folic acid. Read More

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http://dx.doi.org/10.1007/s11894-014-0391-3DOI Listing
December 2014
4 Reads
3 Citations

[Tropical sprue as a differential diagnosis to coeliac disease in a patient on immunosuppressive medication].

Ugeskr Laeger 2014 Jan;176(1):62-3

Medicinsk Gastroenterologisk Afdeling S, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense.

A Danish woman who was on immunosuppressive medication due to a previous liver transplantation travelled to Indonesia for three weeks. After returning she developed nonfebrile severe, watery diarrhoea, dehydration and malnutrition. A thorough examination revealed small intestine changes, which were compatible with coeliac disease. Read More

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January 2014
2 Reads

Tropical sprue: revisiting an underrecognized disease.

Am J Surg Pathol 2014 May;38(5):666-72

*Envoi Specialist Pathologists †Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women's Hospital §The Conjoint Gastroenterology Laboratory ¶Cancer and Population Studies Group, Queensland Institute of Medical Research, Bancroft Centre ∥School of Medicine, University of Queensland, Herston ‡Sullivan Nicolaides Pathology, Taringa, QLD, Australia.

Tropical sprue is an acquired chronic diarrheal disorder of unclear etiology affecting residents of and visitors to tropical regions. Patients usually present with profuse diarrhea, weight loss, and malabsorption, notably of vitamin B12 and folate. The histologic changes typically resemble that of gluten-sensitive enteropathy. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000153DOI Listing
May 2014
3 Reads

Neurologic manifestations of malabsorption syndromes.

Handb Clin Neurol 2014 ;120:621-32

Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

Although malabsorption is generally considered to be a gastrointestinal problem, the effects of malabsorption extend far beyond the gastrointestinal tract and can include neurologic dysfunction. Malabsorption may occur by a variety of mechanisms, both genetic and acquired, that interfere with the absorption of basic nutrients, vitamins, minerals, and trace elements. Disorders that interfere with fat absorption can lead to neurologic dysfunction as a consequence of associated impairment of fat-soluble vitamin absorption. Read More

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http://dx.doi.org/10.1016/B978-0-7020-4087-0.00042-5DOI Listing
April 2014
2 Reads

The clinical significance of duodenal lymphocytosis with normal villus architecture.

Arch Pathol Lab Med 2013 Sep;137(9):1216-9

Department of Pathology, University of Michigan Health System, Ann Arbor, 48109, USA.

Context: The finding of increased intraepithelial lymphocytes with normal villous architecture (Marsh I lesion) is seen in up to 3% of duodenal biopsies. The differential diagnosis includes a wide range of possibilities, including celiac disease, bacterial overgrowth, nonsteroidal antiinflammatory drug damage, reaction to Helicobacter pylori infection, tropical sprue, and chronic inflammatory bowel disease.

Objectives: To highlight the histologic features of the Marsh I lesion, review the diseases and conditions associated with that finding, and to provide pathologists with a rationale and a template for how to identify and report such cases. Read More

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http://dx.doi.org/10.5858/arpa.2013-0261-RADOI Listing
September 2013
3 Reads

Clinical utility of retrograde terminal ileum intubation in the evaluation of chronic non-bloody diarrhea.

J Dig Dis 2013 Oct;14(10):536-42

Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Objective: The aims of this study were to investigate the frequency and factors involved in the terminal ileum intubation of patients with chronic, non-bloody diarrhea and to compare diagnostic yields of colonoscopy and ileocolonoscopy.

Methods: The medical records of 945 patients undergoing colonoscopy for chronic, non-bloody diarrhea were reviewed. Findings of microscopic colitis, Clostridium difficile colitis, celiac disease, inflammatory bowel disease or tropical sprue were considered as definitive causes of diarrhea. Read More

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http://dx.doi.org/10.1111/1751-2980.12082DOI Listing
October 2013
6 Reads

A presentation of latent tropical sprue in a Canadian hospital.

Eur J Gastroenterol Hepatol 2013 Aug;25(8):996-1000

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Tropical sprue (TS) is a chronic diarrheal disease of unknown etiology characterized by malabsorption and small bowel mucosal abnormalities. TS affects residents of, and visitors to, endemic tropical regions. Rarely the disease may remain latent for several years, and to date, few cases of latent TS have been reported in Europe or North America. Read More

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http://dx.doi.org/10.1097/MEG.0b013e328361ce81DOI Listing
August 2013
4 Reads

Tropical sprue: two cases report and review of literature. Has anything changed in the past 40 years?

J Med Assoc Thai 2013 Feb;96 Suppl 2:S266-9

Digestive Institute, Samitivej Sukhumvit Hospital, Bangkok, Thailand.

Background: Tropical sprue is an acquired condition seldom reported in travelers from tropical countries including Thailand. Only one case report from Thailand was reported in 1969.

Case Report: The authors report two cases of American residents living in Thailand and Vietnam who had been suffering from chronic diarrhea, weight loss, being easily fatigued and nutritional deficiency and who dramatically responded after treatment for tropical sprue. Read More

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February 2013
3 Reads

Pathogenesis of tropical sprue: a pilot study of antroduodenal manometry, duodenocaecal transit time & fat-induced ileal brake.

Indian J Med Res 2013 Jan;137(1):63-72

Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Background & Objectives: Small intestinal bacterial overgrowth (SIBO) due to ileal brake-induced hypomotility may cause tropical sprue (TS). We evaluated effect of infusion of fat or placebo in duodenum randomly in patients with TS and healthy controls on antroduodenal manometry (ADM) and mediators of ileal brake, and duodenocaecal transit time (DCTT).

Methods: ADM and DCTT (lactulose hydrogen breath test, HBT) were evaluated with placebo and fat in eight controls and 13 patients with TS (diagnostic criteria: tests showing malabsorption of two unrelated substances, abnormal duodenal histology, absence of other causes, response to antibiotics and folate). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657900PMC
January 2013
21 Reads
4 Citations
1.661 Impact Factor

Tropical sprue: a riddle wrapped in a mystery inside an enigma.

Authors:
B S Ramakrishna

Indian J Med Res 2013 Jan;137(1):12-4

Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657874PMC
January 2013
3 Reads

Diarrhoea due to small bowel diseases.

Best Pract Res Clin Gastroenterol 2012 Oct;26(5):581-600

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Small intestinal diseases are a common, though often overlooked cause of diarrhoeal illness. Fully 1% of the Caucasian population are affected by coeliac disease and a substantial portion of children living in poverty in the developing world are affected by environmental enteropathy. These are but two examples of the many diseases that cause mucosal injury to the primary digestive and absorptive organ in our body. Read More

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http://dx.doi.org/10.1016/j.bpg.2012.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621726PMC
October 2012
3 Reads

Spectrum of malabsorption syndrome among adults & factors differentiating celiac disease & tropical malabsorption.

Indian J Med Res 2012 Sep;136(3):451-9

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Background & Objectives: Aetiology of malabsorption syndrome (MAS) differs in tropical and temperate countries over time; clinical and laboratory parameters may differentiate between various causes. This study was undertaken to investigate the spectrum of MAS among Indian adults and to find out the features that may help to differentiate between TM and celiac disease.

Methods: Causes of MAS, and factors differentiating tropical malabsorption (TM) from celiac disease (CD) were determined in 275 patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510892PMC
September 2012
9 Reads
6 Citations
1.661 Impact Factor

[Tropical sprue in an expatriate].

Rev Med Interne 2012 May 8;33(5):284-7. Epub 2012 Mar 8.

Clinique médicale, HIA du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France.

Introduction: Tropical sprue is a postinfective malabsorption syndrome that occurs in some tropical endemic areas.

Case Report: A 65-year-old Caucasian patient, with no significant past medical history, living in Cambodia for 10 years, presented with a 23 kg weight loss and chronic diarrhea. Clinical examination was unremarkable. Read More

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http://dx.doi.org/10.1016/j.revmed.2012.01.015DOI Listing
May 2012
4 Reads

Spectrum of malabsorption in India--tropical sprue is still the leader.

J Assoc Physicians India 2011 Jul;59:420-2

Department of Gastrointestinal Sciences, Christian Medical College & Hospital, Vellore 632 004.

Introduction: Two decades ago tropical sprue, Immunoproliferative Small Intestinal Disease (IPSID) and infections were common causes of malabsorption in India. It is possible that implementation of preventive health measures and improved sanitation may have changed the spectrum of disorders causing malabsorption. The aim of this study therefore was to assess the spectrum of malabsorption seen at our center during the past nine years. Read More

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July 2011
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Is the ghost of tropical sprue re-surfacing after its obituary?

Authors:
Uday C Ghoshal

J Assoc Physicians India 2011 Jul;59:409-10

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July 2011
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Post-infectious irritable bowel syndrome: the past, the present and the future.

J Gastroenterol Hepatol 2011 Apr;26 Suppl 3:94-101

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Background: Irritable bowel syndrome (IBS), once thought to be a psychosomatic disease, is being considered to be more organic. Post-infectious IBS (PI-IBS), defined as acute onset IBS (by Rome criteria) after gastrointestinal infection in an individual without prior IBS with two or more of the followings: fever, vomiting, diarrhea, a positive stool culture. The recent and old literature of PI-IBS will be reviewed. Read More

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http://dx.doi.org/10.1111/j.1440-1746.2011.06643.xDOI Listing
April 2011
2 Reads

Current spectrum of malabsorption syndrome in adults in India.

Indian J Gastroenterol 2011 Feb 3;30(1):22-8. Epub 2011 Mar 3.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Aim: Tropical sprue was considered to be the most important cause of malabsorption in adults in India. However, several reports indicate that celiac disease is now recognized more frequently.

Methods: We analyzed the clinical presentation, endoscopic and histological features of 94 consecutive patients (age >12 years) with chronic diarrhea and malabsorption syndrome. Read More

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http://link.springer.com/10.1007/s12664-011-0081-0
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http://dx.doi.org/10.1007/s12664-011-0081-0DOI Listing
February 2011
31 Reads
9 Citations

The Face of Tropical Sprue in 2010.

Case Rep Gastroenterol 2010 May 19;4(2):168-172. Epub 2010 May 19.

Department of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Ariz., USA.

Tropical sprue (TS), although endemic in certain tropical regions of the world, is rarely seen in North America and Europe. However, in this era of globalization and worldwide travel, it is important for all clinicians to be aware of the possibility of TS in patients presenting with nonspecific, persistent gastrointestinal complaints like diarrhea and weight loss. The symptoms and histologic findings of TS can resemble and be confused with those of diseases seen more commonly in nontropical climates like celiac disease and small intestine bacterial overgrowth. Read More

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http://dx.doi.org/10.1159/000314231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929410PMC
May 2010
3 Reads

Plasma citrulline as a quantitative biomarker of HIV-associated villous atrophy in a tropical enteropathy population.

Clin Nutr 2010 Dec 19;29(6):795-800. Epub 2010 Jun 19.

Department of Gastroenterology, University College Hospital, London, United Kingdom.

Background & Aims: Studies have shown that the circulating citrulline concentration is decreased in patients with proximal small bowel villous atrophy from coeliac disease and more so in patients with extensive damage to the intestinal mucosa, but there have been few data on HIV enteritis and tropical enteropathy (TE). Our primary aim was to correlate serum citrulline with the degree of reduction of the enterocyte mass in HIV-infected patients with TE.

Methods: Postabsorptive fasting serum citrulline was measured in 150 TE pts, 44 of whom had HIV infection, using reverse phase, high performance liquid chromatography. Read More

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http://dx.doi.org/10.1016/j.clnu.2010.04.008DOI Listing
December 2010
8 Reads

Abnormal small intestinal permeability in patients with idiopathic malabsorption in tropics (tropical sprue) does not change even after successful treatment.

Dig Dis Sci 2011 Jan 22;56(1):161-9. Epub 2010 Apr 22.

Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India.

Background: Though tropical sprue (TS) is common in tropics, studies on small intestinal permeability (SIP) in TS are scant.

Method: SIP was evaluated using (1)H nuclear magnetic resonance (NMR) spectroscopy of urinary lactulose and mannitol in 24 patients with TS (22 before and 15 after treatment with tetracycline and folate) and in 31 healthy subjects (HS). Effect of treatment of TS on SIP and its relationship with outcome were studied. Read More

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http://link.springer.com/10.1007/s10620-010-1232-3
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http://dx.doi.org/10.1007/s10620-010-1232-3DOI Listing
January 2011
6 Reads

Child undernutrition, tropical enteropathy, toilets, and handwashing.

Authors:
Jean H Humphrey

Lancet 2009 Sep;374(9694):1032-1035

Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; ZVITAMBO project, Harare, Zimbabwe. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(09)60950-8DOI Listing
September 2009
2 Reads

13C-sucrose breath test: novel use of a noninvasive biomarker of environmental gut health.

Pediatrics 2009 Aug 5;124(2):620-6. Epub 2009 Jul 5.

aInfectious Diseases Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objective: Environmental enteropathy syndrome may compromise growth and predispose to infectious diseases in children in the developing world, including Australian Aboriginal children from remote communities of the Northern Territory. In this study, we described the use of a biomarker (13)C-sucrose breath test (SBT) to measure enterocyte sucrase activity as a marker of small intestinal villus integrity and function.

Methods: This was a hospital-based prospective case-control study of Aboriginal and non-Aboriginal children with and without acute diarrheal disease. Read More

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http://dx.doi.org/10.1542/peds.2008-2257DOI Listing
August 2009
5 Reads

[Tropical sprue: an unusual differential diagnosis in chronic diarrhea].

Authors:
G Birkenfeld

Dtsch Med Wochenschr 2009 Jul 1;134(28-29):1478-82. Epub 2009 Jul 1.

Klinik und Poliklinik für Innere Medizin I der Universität Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1055/s-0029-1225304DOI Listing
July 2009
2 Reads

Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue.

Gastrointest Endosc 2007 Aug;66(2):377-82

Department of Gastroenterology, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.

Background: Intestinal lesions in celiac disease (CD) and tropical sprue (TS) can be patchy. Improved endoscopic identification of affected areas may increase the diagnostic yield of biopsy specimens. Enhanced magnification endoscopy [EME] combines magnification endoscopy with 3% acetic acid instillation. Read More

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http://dx.doi.org/10.1016/j.gie.2007.02.041DOI Listing
August 2007
7 Reads