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Is There a Predictive Factor for Autoimmune Glanduler Disease Association in Children Diagnosed with Celiac Disease?

J Clin Res Pediatr Endocrinol 2022 Jun 30. Epub 2022 Jun 30.

İnonu University, Faculty of Medicine, Departments of Pediatric Gastroenterology, Hepatology, and Nutrition, Malatya, Turkey.

Objective: There is a close relationship between Celiac Disease (CD) and glandular autoimmunity. The aim of this study is to determine the predictive factors for AGD in children with CD.

Methods: The study included 228 pediatric patients, who were diagnosed with CD between 2010 and 2019. Read More

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Eosinophils, Hypoxia-Inducible Factors, and Barrier Dysfunction in Functional Dyspepsia.

Front Allergy 2022 31;3:851482. Epub 2022 May 31.

NHMRC Centre of Research Excellence in Digestive Health, University of Newcastle, Newcastle, NSW, Australia.

Functional dyspepsia (FD) is a highly prevalent disorder of gut-brain interaction (DGBI), previously known as a functional gastrointestinal disorder. Characterized by early satiety, postprandial fullness, and/or epigastric pain or burning, diagnosis depends on positive symptomatology and exclusion of obvious structural diseases. A subtle inflammatory phenotype has been identified in FD patients, involving an increase in duodenal mucosal eosinophils, and imbalances in the duodenal gut microbiota. Read More

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Development of a Sequence Searchable Database of Celiac Disease-Associated Peptides and Proteins for Risk Assessment of Novel Food Proteins.

Front Allergy 2022 26;3:900573. Epub 2022 May 26.

Food Allergy Research and Resource Program (FARRP), Department of Food Science and Technology, University of Nebraska, Lincoln, NE, United States.

Celiac disease (CeD) is an autoimmune enteropathy induced by prolamin and glutelin proteins in wheat, barley, rye, and triticale recognized by genetically restricted major histocompatibility (MHC) receptors. Patients with CeD must avoid consuming these proteins. Regulators in Europe and the United States expect an evaluation of CeD risks from proteins in genetically modified (GM) crops or novel foods for wheat-related proteins. Read More

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Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives.

Psoriasis (Auckl) 2022 22;12:151-176. Epub 2022 Jun 22.

The University of California, San Francisco, Department of Dermatology, San Francisco, CA, USA.

Nutrition is a complex topic encompassing diet and a variety of supplements including vitamins, fish oil, herbal products, and probiotics. Patients with psoriasis display high interest in understanding the potential impact of nutritional modifications on their psoriasis. In this review, we examine the evidence for nutritional interventions in psoriasis and summarize important concepts. Read More

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[Celiac disease associated with type 1 diabetes mellitus in a child].

Zhonghua Er Ke Za Zhi 2022 Jul;60(7):712-714

Department of Gastroenterology,Children's Hospital,Capital Institute of Pediatrics, Beijing 100020, China.

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Distribution of celiac disease predisposing genes HLA-DQ2 and HLA-DQ8 in the native population of southern India.

Indian J Gastroenterol 2022 Jun 29. Epub 2022 Jun 29.

Department of Pediatrics, Università Politecnica delle Marche, 60123, Ancona, Italy.

Background: Celiac disease (CD) is an intestinal inflammatory condition caused by the ingestion of gluten peptides in wheat and related grains in individuals carrying HLA-DQ2 and/or HLA-DQ8 genes. In comparison to HLA-DQ8, a higher HLA-DQ2 prevalence is reported in European population where wheat has been the staple food for thousands of years. In non-European population, this pattern of HLA-DQ CD-predisposing gene distribution has not always been found. Read More

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ESPGHAN position paper on management and follow-up of children and adolescents with coeliac disease.

J Pediatr Gastroenterol Nutr 2022 Jun 27. Epub 2022 Jun 27.

Dept. of Translational Medical Sciences and European Laboratory for the Investigation of Food-Induced Diseases, University of Naples Federico II, Naples, Italy.

Aim: To gather the current evidence and to offer recommendations for follow-up and management.

Methods: The Special Interest Group on Coeliac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010 - March 2020) was performed in PubMed or Medline. Read More

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Comparative characterization of the gluten and fructan contents of breads from industrial and artisan bakeries: a study of food products in the Spanish market.

Food Nutr Res 2022 10;66. Epub 2022 Jun 10.

Department of Plant Breeding, Institute of Sustainable Agriculture (IAS), Spanish Council for Scientific Research (CSIC), Córdoba, Spain.

Background: The consumption of wheat/gluten is associated with adverse reactions for human health. Gluten and fructans are identified as the major compounds triggering and worsening adverse reactions to wheat, which are increasing, and as a consequence, avoidance of gluten/wheat is the common strategy of many individuals of the western population. Although bread is a product of daily consumption, there is a lack of information on the gluten and fructan contents and the influence of artisanal or industrial processes. Read More

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Late presentation of lane-hamilton syndrome in a 33 year old female: A case report.

Int J Appl Basic Med Res 2022 Apr-Jun;12(2):137-139. Epub 2022 May 10.

Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Lane-Hamilton syndrome (LHS) is a rare syndromic association between idiopathic pulmonary hemosiderosis and celiac disease (CD). It is usually seen in children below 15 years of age. It can occasionally be seen in adults. Read More

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Spectrum of chronic gastrointestinal diseases with final outcome in children at a tertiary care centre: A single-centre study.

J Pak Med Assoc 2022 Jun;72(6):1188-1192

Department of Anaesthesia, Pakistan Kidney and Liver Institute and Research Centre, Lahore, Pakistan.

Chronic gastrointestinal (GI) diseases in children present with a wide range of symptoms. Limited resources in Paediatric Gastroenterology in developing countries like Pakistan cause considerable difficulties in managing children with chronic GI diseases in a timely fashion. This retrospective descriptive study aimed to determine the spectrum and outcomes of chronic GI diseases in children. Read More

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Estimating typhoid incidence from community-based serosurveys: a multicohort study.

Lancet Microbe 2022 Jun 21. Epub 2022 Jun 21.

Center for Celiac Research and Treatment, MassGeneral Hospital for Children, Boston, MA, USA; Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, MA, USA; Harvard Medical School, Harvard University, Boston, MA, USA.

Background: The incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae (Salmonella enterica serovars Typhi and Paratyphi), is largely unknown in regions without blood culture surveillance. The aim of this study was to evaluate whether new diagnostic serological markers for typhoidal Salmonella can reliably estimate population-level incidence.

Methods: We collected longitudinal blood samples from patients with blood culture-confirmed enteric fever enrolled from surveillance studies in Bangladesh, Nepal, Pakistan, and Ghana between 2016 and 2021 and conducted cross-sectional serosurveys in the catchment areas of each surveillance site. Read More

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Letter: progressive weakening of the concept that gluten has a detrimental effect on mental health and gut symptoms in the absence of coeliac disease.

Aliment Pharmacol Ther 2022 Jul;56(2):363-364

Department of Gastroenterology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

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Editorial: lack of gastrointestinal symptoms caused by gluten in patients without coeliac disease-time to ditch the 'gluten' from 'non-coeliac gluten sensitivity'.

Jason A Tye-Din

Aliment Pharmacol Ther 2022 Jul;56(2):340-341

Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

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Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study.

Nutrients 2022 Jun 15;14(12). Epub 2022 Jun 15.

Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55907, USA.

Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) are poorly defined. To evaluate the structural and inflammatory features of NCGS compared to controls and coeliac disease (CeD) with milder enteropathy (Marsh I-II). Well-oriented biopsies of 262 control cases with normal gastroscopy and histologic findings, 261 CeD, and 175 NCGS biopsies from 9 contributing countries were examined. Read More

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Adherence to Gluten-Free Diet Restores Alpha Diversity in Celiac People but the Microbiome Composition Is Different to Healthy People.

Nutrients 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Agriculture, Food, Natural Resources and Engineering (DAFNE), University of Foggia, 71122 Foggia, Italy.

Celiac disease (CD) is an autoimmune disease with the destruction of small intestinal villi, which occurs in genetically predisposed individuals. At the present moment, a gluten-free diet (GFD) is the only way to restore the functionality of gut mucosa. However, there is an open debate on the effects of long-term supplementation through a GFD, because some authors report an unbalance in microbial taxa composition. Read More

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PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases.

Int J Mol Sci 2022 Jun 14;23(12). Epub 2022 Jun 14.

1st Department of Pediatrics, Semmelweis University, 1083 Budapest, Hungary.

It is increasingly known that Parkinson's (PD) and Alzheimer's (AD) diseases occur more frequently in patients with inflammatory gastrointestinal diseases including inflammatory bowel (IBD) or celiac disease, indicating a pathological link between them. Although epidemiological observations suggest the existence of the gut-brain axis (GBA) involving systemic inflammatory and neural pathways, little is known about the exact molecular mechanisms. Parkinson's disease 7 (PARK7/DJ-1) is a multifunctional protein whose protective role has been widely demonstrated in neurodegenerative diseases, including PD, AD, or ischemic stroke. Read More

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The Association between ADHD and Celiac Disease in Children.

Sonia Gaur

Children (Basel) 2022 May 25;9(6). Epub 2022 May 25.

Department of Psychiatry, Stanford School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA.

Controversy around the association between celiac disease (CeD) and attention deficit hyperactive disorder (ADHD) was addressed by a systematic review in 2015, ultimately showing no association. Since 2015, there have been several studies showing an association between celiac disease and attention deficit hyperactive disorder. This is an updated systematic review. Read More

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Circulating microRNAs Suggest Networks Associated with Biological Functions in Aggressive Refractory Type 2 Celiac Disease.

Biomedicines 2022 Jun 14;10(6). Epub 2022 Jun 14.

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Street Pascal 36, 20133 Milan, Italy.

Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Read More

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Evaluation of mucosal status in the follow-up of pediatric patients with celiac disease: the role of serology.

Eur J Pediatr 2022 Jun 23. Epub 2022 Jun 23.

Div. of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University School of Medicine, Başıbüyük Campus, Maltepe Başıbüyük Yolu Sok. No:9/1, 34854, Maltepe, Istanbul, Turkey.

Recent guidelines suggest non-biopsy serology-based approach for the diagnosis of celiac disease; however, there is no evidence-based data regarding noninvasive follow-up of mucosal healing. The aim of this study is to investigate the efficacy of serology in reflecting mucosal status in the follow-up of pediatric patients with celiac disease. This is a validation study conducted at a university hospital. Read More

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Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project-Global Strategy Protocol.

Pediatr Rep 2022 Jun 10;14(2):293-311. Epub 2022 Jun 10.

Dipartimento di Matematica e Informatica, Università di Palermo, 90133 Palermo, Italy.

Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate the need for intestinal biopsy. Read More

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Links between celiac disease and small intestinal bacterial overgrowth: A systematic review and meta-analysis.

J Gastroenterol Hepatol 2022 Jun 22. Epub 2022 Jun 22.

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background And Aim: Symptoms of small intestinal bacterial overgrowth (SIBO) and celiac disease (CeD) often overlap, and studies suggest a link between SIBO and CeD. We thus conducted a systematic review and meta-analysis to compare SIBO prevalence in CeD patients and controls and assessed effects of antimicrobial therapy on gastrointestinal symptoms in SIBO positive CeD patients.

Methods: Electronic databases were searched until February 2022 for studies reporting SIBO prevalence in CeD. Read More

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Harefuah 2022 Jun;161(6):383-389

Department of Surgery A, Soroka University Medical Center, Beer-Sheva, Israel.

Introduction: Pancreatic cancer (PC) is the 11th most common malignancy worldwide, however, entailing a mortality in excess of 90% within 5 years from diagnosis, it is the 4th most fatal malignant disease. PC is commonly diagnosed at an advanced stage, in which curative resection is no longer possible. Even patients who present with potentially curable disease will have upward of 30% recurrence of their disease within the first year. Read More

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Effect of extrusion on the modification of wheat flour proteins related to celiac disease.

J Food Sci Technol 2022 Jul 11;59(7):2655-2665. Epub 2021 Oct 11.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047 People's Republic of China.

Wheat flour was extruded using a single- and double-screw extruder at 130, 150, and 170 °C, respectively, to determine the effect of extrusion on the content and possible modifications of protein in wheat flour. Regarding to proteins, their yield under non-reducing extraction conditions (in SDS only) decreased to one-third after extrusion-but remained constant after extraction under reduced conditions (in SDS + DTT). This phenomenon possibly reflected protein cross-linking through intermolecular disulfide bonds to gluten proteins, especially at high temperature and high screw speed during double-screw extrusion, as suggested by the increased number of free-SH-groups and reduced intensity of low-MW proteins in SDS-PAGE under this extrusion condition. Read More

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The Activity of Antimicrobial Peptides in Pediatric Celiac Disease.

Front Pediatr 2022 6;10:873793. Epub 2022 Jun 6.

Gastroenterology Department of Republican Specialized Scientific-Practical Medical Center of Pediatrics Ministry of Health of Republic of Uzbekistan, Tashkent, Uzbekistan.

Background: Celiac disease (CD) is an immune-mediated disorder of the gut in which innate and adaptive responses are involved. Antimicrobial peptides (AMPs) constitute an arsenal of innate immunity regulators of paramount importance in the gut. However, the role of AMPs in CD is unclear. Read More

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Pandemic-Related Social Disruption and Well-Being in Pediatric Gastrointestinal Diseases.

J Pediatr Psychol 2022 Jun 22. Epub 2022 Jun 22.

Division of Gastroenterology, Hepatology, & Nutrition, Emory University School of Medicine, USA.

Objective: The coronavirus disease 2019 (COVID-19) pandemic has impacted everyone, but there are few data regarding how the pandemic has influenced the lives of children with gastrointestinal (GI) conditions. This cross-sectional study assessed pandemic-related social disruption (PRSD) in children with inflammatory bowel disease (IBD), celiac disease (CD), and irritable bowel syndrome (IBS), and the potential buffering effect of the parent-child relationship.

Methods: A survey completed between September and December 2020 asked 146 children (ages 8-17) diagnosed with IBD (n = 44), CD (n = 81), or IBS (n = 51) and 185 parents how the pandemic has contributed to social disruption (i. Read More

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The Association of Inflammatory Gut Diseases with Neuroinflammatory and Auditory Disorders.

Front Biosci (Elite Ed) 2022 Mar;14(2)

Department of Physiology and The Eisdell Moore Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 1142 Auckland, New Zealand.

Disorders such as inflammatory bowel disease (IBD) and celiac disease (CeD) result in intestinal hyperpermeability or 'leaky' gut. The increased permeability of the intestinal barrier allows microbial metabolites, toxins, and pathogens to infiltrate the bloodstream and extraintestinal tissues, causing systemic inflammation. Despite differences in aetiology and pathophysiology, IBD and CeD share several extraintestinal manifestations such as neuroinflammation, neurological and psychiatric manifestations, and sensorineural hearing loss (SNHL). Read More

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