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Rev Gastroenterol Peru 2018 Jul-Sep;38(3):228-233
Departamento de Inmunología, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción. San Lorenzo, Paraguay.
IgA anti-transglutaminase 2 (tTG2) antibody is a relevant marker in celiac disease. The utility of IgA anti-tTG2 determination is well established for the diagnosis, however their use in the follow-up of patients with gluten free diet (GFD) it is not fully established.
Objective: To determine IgA anti-tTG2 antibody levels in adult Paraguayan celiac disease patients and its relation to the presence and duration of the GFD. Read More
Methods Mol Biol 2019 ;1901:197-203
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA.
Appearance of autoantibodies to tissue transglutaminase (TGA) is the most reliable biomarker to identify celiac disease autoimmunity. A nonradioactive assay of determination of TGA was newly developed using electrochemiluminescence (ECL) technology. This ECL assay has been demonstrated to be more sensitive than current standard radio-binding assay (RBA) in detecting TGA and can detect TGA earlier among high-risk young children followed from birth. Read More
Front Immunol 2018 20;9:2617. Epub 2018 Nov 20.
Faculty of Medicine, Nursing and Health Sciences, School of Biomedical Sciences, Monash University, Clayton, VIC, Australia.
The rising global incidence of autoimmune and inflammatory conditions can be attributed to changes in the large portion of the immune system that belongs to our gastrointestinal tract (GI). The intestinal immune system serves as a gatekeeper to prevent pathogenic invasions and to preserve a healthier gut microbiota. The gut microbiota has been increasingly studied as a fundamental contributor to the state of health and disease. Read More
Eur J Intern Med 2018 Dec 5. Epub 2018 Dec 5.
Institute for Translational Immunology, Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, 55101 Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Celiac disease (CD) is the most common autoimmune enteropathy worldwide. In CD, dietary gluten triggers a T cell driven small intestinal inflammation in a subset of genetically predisposed subjects, expressing the HLA DQ2 and/or DQ8 genes on their antigen presenting cells. HLA DQ2/DQ8 can bind gluten peptides after their prior modification by the CD autoantigen, tissue transglutaminase (TG2). Read More
Nutr Res 2018 Dec 21;60:54-67. Epub 2018 Sep 21.
PepsiCo R&D Measurement Sciences, 617 W Main St, Barrington, IL 60010, USA.
Inclusion of oats in a gluten-free (GF) diet can provide whole grain nutritional benefits to celiac disease (CD) patients, but there has been debate regarding oat safety for these individuals. This is because of conflicting research findings, with inconsistencies attributed to varying CD subject's sensitivities to "pure" oats. Clinical trials to date have assumed oats provided to subjects to be lightly contaminated, if at all. Read More
Front Pediatr 2018 21;6:350. Epub 2018 Nov 21.
The Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. Read More
Gut Pathog 2018 29;10:49. Epub 2018 Nov 29.
7Physics Department, Boston University, Boston, USA.
Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population. Read More
Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.
O Dekkers, Internal Medicine, Leids Universitair Medisch Centrum, Leiden, Netherlands.
Introduction: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking.
Methods: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. Read More
Neurol India 2018 Nov-Dec;66(6):1810-1812
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Dis Model Mech 2018 Nov 28;11(12). Epub 2018 Nov 28.
Department of Biological Sciences, Binghamton University, Binghamton, New York 13902, USA
Increased intestinal barrier permeability has been correlated with aging and disease, including type 2 diabetes, Crohn's disease, celiac disease, multiple sclerosis and irritable bowel syndrome. The prevalence of these ailments has risen together with an increase in industrial food processing and food additive consumption. Additives, including sugar, metal oxide nanoparticles, surfactants and sodium chloride, have all been suggested to increase intestinal permeability. Read More
Biotechnol Bioeng 2018 Dec 5. Epub 2018 Dec 5.
Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, India.
Celiac disease (CD) is an intestinal issue activated by the inappropriate immune reaction towards gluten protein of wheat, rye, barley, oats, and autoantigen, tissue transglutaminase. Regardless of the accessibility of immunochemical conventions for research facility analysis of CD, there is as yet a need of speedier, less expensive, and simpler devices for diagnosing CD. This review concentrates on progresses in biosensors for diagnosing CD in perspective of the scaled down hardware, multianalyte discovery and low sample volume necessity. Read More
Nutrients 2018 Dec 3;10(12). Epub 2018 Dec 3.
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
Gluten-free (GF) eating patterns are frequently perceived to be healthier than gluten-containing (GC) ones, but there has been very little research to evaluate this viewpoint. The effect of GF eating patterns on dietary composition was assessed using two independent approaches. One approach compared macronutrients and typical shortfall nutrients between MyPlate example menus developed with either GC or equivalent GF foods. Read More
Rev Esp Enferm Dig 2018 Dec 4;111. Epub 2018 Dec 4.
Anatomía Patológica, Hospital Universitario La Paz, España.
Mycophenolate mofetil (MMF) is an immunosuppressive agent that is used in transplanted patients, with frequent gastrointestinal adverse effects. We report the case of a patient, under chronic therapy with mycophenolate mofetil , during a diagnostic workup for a chronic diarrhea, which presents a duodenal villous atrophy ( VA) with negative celiac serology, which is a diagnostic challenge. VA secondary to MMF is a very unusual adverse effect. Read More
Ann Vasc Surg 2018 Nov 27. Epub 2018 Nov 27.
Faculty of Medicine of the University of Porto; Department of Angiology and Vascular Surgery, Hospital de S. João, Porto, Portugal.
Introduction: Only a minority of vascular surgeons have personal experience on thoracoabdominal aneurysm (TAA) repair, and even less have performed surgery on these formidable lesions for rupture. Unsurprisingly, when open surgery was the only treatment option available, these impressive pathologies were frequently deemed inoperable and managed conservatively. Endovascular techniques brought new hope in these scenarios, but despite current advances, morbidity and mortality remains high, even in experienced centres. Read More
Ann Vasc Surg 2018 Nov 27. Epub 2018 Nov 27.
NYU Langone Hospital-Brooklyn, 150 55th St, Brooklyn, NY 11220.
Isolated celiac artery vasculitis is an uncommon disease rarely reported in western literature. In this case report, we describe a 52-year-old Chinese male presenting with abdominal pain who was diagnosed with non-specific celiac artery vasculitis and was successfully treated with a short course of oral corticosteroids. Read More
J Pediatr Gastroenterol Nutr 2018 Nov 27. Epub 2018 Nov 27.
Department of Medicine, Surgery, and Health Sciences, University of Trieste, Trieste, Italy.
Objectives: Available data indicate that liver involvement is present in a significant proportion of children with celiac disease (CD) at the diagnosis (elevated transaminases 15-57%, autoimmune liver disease 1-2%). We sought to evaluate prevalence, clinical course, and risk factors for liver involvement in a large cohort of children with CD.
Methods: Children (age 0-18 years) diagnosed with CD from March 2010 to April 2016 were enrolled. Read More
Appl Immunohistochem Mol Morphol 2018 Nov 28. Epub 2018 Nov 28.
Department of Pathology and Cell Biology.
Background: Utilization rates of immunohistochemistry (IHC) for the diagnosis of Helicobacter pylori infection may vary by laboratory and/or pathologists. IHC for H. pylori is not performed routinely in our practice. Read More
Cell Mol Life Sci 2018 Nov 29. Epub 2018 Nov 29.
Amsterdam Rheumatology and immunology Center, Academic Medical Center (AMC), Amsterdam, The Netherlands.
The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body. However, recently, it has become clear that in humans IgA is also able to actively contribute to the initiation of inflammation, both at mucosal and non-mucosal sites. This additional function of IgA is initiated by the formation of immune complexes, which trigger Fc alpha Receptor I (FcαRI) to synergize with various other receptors to amplify inflammatory responses. Read More
EMBO J 2018 Nov 29. Epub 2018 Nov 29.
European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted T1 immune and antibody response leading to celiac disease. Prior epithelial stress and innate immune activation are essential for breaking oral tolerance to the gluten component gliadin. Read More
HLA 2018 Nov 28. Epub 2018 Nov 28.
Blood Transfusion Centre of Slovenia, Tissue Typing Center, Ljubljana, Slovenia.
As presented at the 12 East-West Immunogenetic Conference in Prague, in the present brief communication I discuss the role of HLA in co-existence of two autoimmune diseases type 1 diabetes (T1D) and celiac disease (CD) as well as the contribution of HLA testing to early diagnosis and prevention of severe clinical manifestations of the diseases with focus on studies performed in Slovenians. This article is protected by copyright. All rights reserved. Read More
Mymensingh Med J 2018 Oct;27(4):820-825
Dr Shohely Parveen, Medical Officer, Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
This descriptive, cross sectional study was conducted at Bangabandhu Sheikh Mujib Medical University from July 2012 to July 2015 to see the occurrence of celiac disease in children with chronic diarrhea. A total of 62 children (age <18 years) attending the Paediatric Gastroenterology and Nutrition department of BSMMU with chronic diarrhoea were enrolled for the study. Mean age of studied children was 7. Read More
JGH Open 2018 Oct 2;2(5):196-200. Epub 2018 Aug 2.
Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.
Background And Aims: Anemia is one of the most common extraintestinal manifestations of celiac disease (CD), with iron deficiency anemia (IDA) being the predominant cause. However, anemia in CD can have varied etiologies, including mixed nutritional deficiency. We aimed to study the prevalence and etiology of anemia in CD in a north Indian population. Read More
JGH Open 2018 Oct 5;2(5):191-195. Epub 2018 Jul 5.
Department of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide Australia.
Background And Aim: Small bowel mucosal biopsies (SBBx) are routinely performed to investigate unexplained anemia; however, previous studies have demonstrated a low yield in diagnosing celiac disease. Our aim was to determine the yield of routine SBBx in a large cohort of patients who underwent gastroscopy for the investigation of anemia.
Methods: Data from consecutive patients who underwent gastroscopy for the investigation of anemia in a tertiary hospital, from January 2008-December 2011, were prospectively collected. Read More
JGH Open 2018 Aug 6;2(4):124-128. Epub 2018 Jun 6.
Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.
Background And Aim: Patients with celiac disease (CD) have a poor health-related quality of life (HR-QOL). We assessed the QOL in patients with CD using both generic (SF-12) and specific (CD-QOL) questionnaires, and the effect of gluten-free diet (GFD) on HR-QOL.
Methods: We conducted a prospective follow-up study based on consecutive patients of suspected CD between June 2014 and November 2015. Read More
Am J Cardiol 2018 Oct 30. Epub 2018 Oct 30.
Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts. Electronic address:
The pathophysiology of spontaneous coronary artery dissection (SCAD) is heterogeneous, associated with systemic arteriopathies and inflammatory diseases, and often compounded by environmental precipitants, genetics, or stressors. However, the frequency of these associated conditions with SCAD on a population level remains unknown. Therefore, the objective of this analysis was to evaluate heterogeneous phenotypes of SCAD in the United States using data from the Nationwide Inpatient Sample collected from January 1, 2004, to September 31, 2015. Read More
J Int Med Res 2018 Nov 26:300060518812623. Epub 2018 Nov 26.
1 Department of Pediatrics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Objective: Celiac disease (CD) is an autoimmune disorder associated with numerous health problems, including reproductive disorders. This study was performed to analyze the association between CD and the menstrual cycle in a group of patients with CD and compare these patients' characteristics with those of healthy women.
Methods: The study included 145 patients with CD (age, 15-51 years) and 162 healthy women (age, 18-55 years). Read More
Nutrients 2018 Nov 23;10(12). Epub 2018 Nov 23.
Department of Paediatrics, Paediatric Hospital Giovanni XXIII, Via Amendola 207, 70126 Bari, Italy.
Recently, the interest in the human microbiome and its interplay with the host has exploded and provided new insights on its role in conferring host protection and regulating host physiology, including the correct development of immunity. However, in the presence of microbial imbalance and particular genetic settings, the microbiome may contribute to the dysfunction of host metabolism and physiology, leading to pathogenesis and/or the progression of several diseases. Celiac disease (CD) is a chronic autoimmune enteropathy triggered by dietary gluten exposure in genetically predisposed individuals. Read More
J Pharmacol Toxicol Methods 2018 Nov 23;95:27-35. Epub 2018 Nov 23.
National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Introduction: Haemophilus parasuis, one of the major swine pathogens, has at least fifteen different types, all of which have significant economic effects on the global swine industry. The aim of this study was to establish an experimental intraperitoneal infection model for H. parasuis in neutropenic guinea pigs. Read More
Gastroenterol Res Pract 2018 24;2018:7848735. Epub 2018 Oct 24.
Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy.
The increment of recording atypical oral manifestation in young patients often related to systematic disease is today a challenge for the therapists. Sometime, the presence of tooth enamel lesions correlated with soft tissue lesions is just a symptom or a trigger sign for a deeper and undetermined disease. Recently, high impact has been developed toward the influence of the diet as a controlled and modifiable factor in patients affected by celiac pathologies. Read More
Nutrients 2018 Nov 21;10(11). Epub 2018 Nov 21.
Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum Faculty of Medicine, University of Warmia & Mazury, Oczapowskiego 2 Str., 10-719 Olsztyn, Poland.
Iron deficiency anemia (IDA) occurs in 15⁻46% of patients with celiac disease (CD), and in some cases, it may be its only manifestation. Studies in animal models have shown that prebiotics, including inulin, may help to increase intestinal absorption of iron. The aim of this study was to evaluate the effect of a prebiotic, oligofructose-enriched inulin (Synergy 1), on iron homeostasis in non-anemic children and adolescents with celiac disease (CD) in association with a gluten-free diet (GFD). Read More
Nutrients 2018 Nov 21;10(11). Epub 2018 Nov 21.
Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszów, 35959 Rzeszów, Poland.
The primary and proven therapy, in cases of celiac disease (CD), is a rigorous gluten-free diet (GFD). However, there are reports of its negative effects in the form of nutritional deficiencies, obesity, and adverse changes in body composition. The study aimed to assess the impact of a GFD on the body composition of children with CD. Read More
Gene 2018 Nov 20;687:280-288. Epub 2018 Nov 20.
Gazi University Faculty of Medicine, Department of Pediatric Metabolic Disorders, Ankara, Turkey; Gazi University Faculty of Medicine, Department of Pediatric Genetic Disorders, Ankara, Turkey. Electronic address:
Fabry disease results from deficiency of the lysosomal enzyme alpha-galactosidase A. The families of 11 index cases were screened by enzyme and molecular assays. Further clinical and laboratory investigations were carried out in all cases. Read More
Med Clin North Am 2019 Jan 1;103(1):89-99. Epub 2018 Nov 1.
Department of Internal Medicine, Division of Digestive and Liver Diseases, University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-9151, USA. Electronic address:
Historically, a gluten-free diet was recommended only for those with celiac disease or IgE-mediated wheat allergy. With changes in food allergy labeling in the United States and the publication of several best-selling books, gluten-related disorders have come to the forefront of popular culture. As a result, there has been a dramatic increase in the number of gluten-free diet followers, many for nontraditional reasons. Read More
J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):372-376
Nusrat Riaz College, Quetta-Pakistan.
Background: Iron deficiency anaemia (IDA) is common in Pakistani population and an important cause of morbidity. Celiac disease (CD) is an important contributor and its diagnosis is frequently missed especially if present in atypical/non-diarrhoeal form. Non-responders to iron replacement therapy typically raises suspicion of celiac disease as underlying cause. Read More
J Clin Lab Anal 2018 Nov 21:e22722. Epub 2018 Nov 21.
Department of Pathology, Ankara Training and Research Hospital, Health Sciences University, Altındağ, Ankara, Turkey.
Background/aims: Today, invasive diagnostic tests are necessary for definite diagnosis of adult celiac disease (CD). However, in selected children patients, the need for invasive tests is ceased. In this study, we evaluated adult patients according to the ESPGHAN (European Pediatric Gastroenterology Hepatology and Nutrition Society) criteria. Read More
J Biol Chem 2018 Nov 19. Epub 2018 Nov 19.
University of Oslo and Oslo University Hospital-Rikshospitalet, Norway.
Celiac disease (CeD) provides an opportunity to study the specificity underlying human T-cell responses to an array of similar epitopes presented by the same human leukocyte antigen-II (HLA-II) molecule. Here, we investigated T-cell responses to the two immunodominant and highly homologous HLA-DQ2.5-restricted gluten epitopes, DQ2. Read More
Clin Gastroenterol Hepatol 2018 Dec;16(12):2002-2003
UBC Hospital, University of British Columbia, Vancouver, Canada.
Nutrients 2018 Nov 18;10(11). Epub 2018 Nov 18.
Division of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, 12203 Berlin, Germany.
The gluten-free diet is the only effective treatment available for celiac disease. However, it is difficult to adhere to and a closer look on the diet's implementation and indications reveals several ambiguities: Not only is there controversy on the threshold of gluten that can be tolerated in the frame of a strict gluten-free diet, but it is also unclear whether the gluten-free diet is an appropriate treatment in patient subgroups with asymptomatic or potential celiac disease. Reports from a number of research groups suggest that a certain proportion of patients may effectively develop tolerance to gluten and thus become suitable for gluten reintroduction over time. Read More
Plants (Basel) 2018 Nov 16;7(4). Epub 2018 Nov 16.
Department of Agriculture and Forest Science (DAFNE), University of Tuscia, Via S. C. de Lellis snc, 01100 Viterbo, Italy.
Although wheat is a staple food for most of the human population, some of its components trigger adverse reactions. Among wheat components, the alpha-amylase/trypsin inhibitors (ATI) are important triggers of several allergies and activators of innate immunity. ATI are a group of exogenous protease inhibitors and include several polypeptides. Read More
Nutrients 2018 Nov 16;10(11). Epub 2018 Nov 16.
Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), CSIC, Avda. de Roma s/n, 33011 Oviedo, Spain.
Celiac disease (CD) is a genetically conditioned autoimmune process that appears in susceptible people. It can affect people of any age, and slightly predominates in females. It has a fairly homogenous global distribution, with an average prevalence of 1⁻2%, the frequency having increased in recent decades. Read More
Clin J Oncol Nurs 2018 Dec;22(6):663-665
Banner Estrella Medical Center.
Background: A majority of patients with abdominal cancer report intractable abdominal pain as their disease progresses. For intractable abdominal pain related to malignancy, celiac plexus block can provide relief and reduce the use of oral opioids, helping to improve quality of life.
Objectives: The aim of this article is to explore the feasibility and effectiveness of celiac plexus block as a pain management option for patients with late-stage abdominal cancer. Read More
Gastrointest Endosc 2018 12;88(6):970-971
Department of Medicine, Government Medical College Hospital 32, Chandigarh, India.
Clin Gastroenterol Hepatol 2018 Nov 15. Epub 2018 Nov 15.
Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN. Electronic address:
Background And Aims: A higher proportion of female vs male patients receive a diagnosis of celiac disease. Little is known about sex-based differences in the prevalence of celiac disease in undiagnosed populations. We aimed to address this knowledge gap with a systematic review and meta-analysis. Read More
Inflammopharmacology 2018 Nov 16. Epub 2018 Nov 16.
Laboratory Rashid Latif College of Pharmacy, Lahore, Pakistan.
Clematis orientalis Linn has long been used as ethnopharmacy for the treatment of arthritis. This study is intended to evaluate the curative efficacy of Clematis orientalis in treating polyarthritis in rats. Aqueous ethanolic extract and fractions (hexane, butanol and aqueous) were administered orally at 200 mg/kg for 28 days after CFA immunization. Read More
Immunobiology 2018 Nov 2. Epub 2018 Nov 2.
Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade 11000, Serbia.
The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Read More
Nutrients 2018 Nov 15;10(11). Epub 2018 Nov 15.
Human Nutrition Unit, Department of Food and Drug, University of Parma, 43121 Parma, Italy.
Our aim was to evaluate the intake of foods containing fermentable oligo/di/mono-saccharides and polyols (FODMAP) as a possible factor that induces gastrointestinal symptoms in treated celiac disease (CD) patients. We collected seven-day weighed food records for 104 CD patients and 91 healthy volunteers. All evaluated food items were from sources with high and low content of FODMAP, which were divided into cereals and sweets, sweeteners and soft drinks, fruits, dried fruits, and vegetables. Read More
Nutrients 2018 Nov 15;10(11). Epub 2018 Nov 15.
Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia & Mazury, Oczapowskiego 2 Str., 10-719 Olsztyn, Poland.
Prebiotics have been shown to improve absorption of some nutrients, including vitamins. This pilot study evaluated the effect of the prebiotic oligofructose-enriched inulin (Synergy 1) on fat-soluble vitamins status, parathormone, and calcium-related elements in pediatric celiac disease (CD) patients ( = 34) on a strict gluten-free diet (GFD). Participants were randomized into a group receiving 10 g of Synergy 1 or placebo (maltodextrin) together with a GFD. Read More
Autoimmunity 2018 Aug 16;51(5):221-227. Epub 2018 Nov 16.
d Department of clinical sciences , Lund University, Skåne University hospital , Malmö , Sweden.
Objectives: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).
Patients And Methods: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA). Read More
Front Microbiol 2018 1;9:2597. Epub 2018 Nov 1.
Department of Biophysics, Panjab University, Chandigarh, India.
Celiac disease (CD) is an autoimmune disorder of the small intestine, caused by gluten induced inflammation in some individuals susceptible to genetic and environmental influences. To date, pathophysiology of CD in relation to intestinal microbiota is not known well. This review relies on contribution of intestinal microbiome and oral microbiome in pathogenesis of CD based on their interactions with gluten, thereby highlighting the role of upper gastrointestinal microbiota. Read More
Cas Lek Cesk 2018 ;157(3):117-121
Celiac disease can be defined as a small bowel disorder characterized by mucosal inflammation, villous atrophy and crypt hyperplasia, which occurs upon exposure to dietary gluten and which demonstrates improvement after withdrawal of gluten from the diet. Keywords: celiac disease, children, adolescents. Read More