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[How to recognize inflammatory wheat sensitivities].

MMW Fortschr Med 2020 Jul;162(13):47-52

Institut für Translationale Immunologie und Ambulanz für Zöliakie-, Dünndarmerkrankungen und Autoimmunität, Allergiezentrum Rheinland-Pfalz, Autoimmunzentrum Rheinland-Pfalz, Deutschland.

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http://dx.doi.org/10.1007/s15006-020-0698-yDOI Listing

The Predictive Value of Serum Cytokines for Distinguishing Celiac Disease from Non-Celiac Gluten Sensitivity and Healthy Subjects.

Iran Biomed J 2020 Jun 1. Epub 2020 Jun 1.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: It has been established that the level of some inflammatory cytokines increases in CD and NCGS in comparison with healthy subjects. Therefore, the primary interest in our research was proposing an accurate tool to diagnose patients with CD and NCGS from healthy individuals in an Iranian population.

Methods: The serum samples were examined in 171 participants, including 110 CD patients, 46 healthy individuals, and 15 NCGS. Read More

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http://dx.doi.org/10.29252/ibj.24.6.335DOI Listing

Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder.

Brain Sci 2020 Jul 9;10(7). Epub 2020 Jul 9.

Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), Institute of Biochemistry, University of Palermo, 90127 Palermo, Italy.

Celiac Disease (CD) is an immune-mediated disease triggered by the ingestion of wheat gliadin and related prolamins from other cereals, such as barley and rye. Immunity against these cereal-derived proteins is mediated by pro-inflammatory cytokines produced by both innate and adaptive system response in individuals unable to adequately digest them. Peptides generated in this condition are absorbed across the gut barrier, which in these patients is characterized by the deregulation of its permeability. Read More

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http://dx.doi.org/10.3390/brainsci10070437DOI Listing

Proteomic modelling of gluten digestion from a physiologically relevant food system: A focus on the digestion of immunogenic peptides from wheat implicated in celiac disease.

Food Chem 2020 Jul 5;333:127466. Epub 2020 Jul 5.

School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Department of Chemical and Materials Engineering The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

Celiac disease is an autoimmune illness activated by gluten peptides produced during gastrointestinal digestion. A simulated in vitro digestion of gluten was conducted to define the profile and kinetic release pattern of immunogenic gluten peptides in a physiologically relevant food matrix. White bread was digested using the INFOGEST in vitro standardised digestion protocol from 0 to 240 min and subsequently analysed by SDS-PAGE, quantitative LC-MS/MS, untargeted LC-MS/MS and ELISA. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127466DOI Listing

TNF-α, IL-17 AND IL-22 PRODUCTION IN THE RECTAL MUCOSA OF NON-CELIAC WHEAT SENSITIVITY PATIENTS: ROLE OF ADAPTIVE IMMUNITY.

Am J Physiol Gastrointest Liver Physiol 2020 Jul 13. Epub 2020 Jul 13.

Internal Medicine, Sciacca Hospital, and University of Palermo, Palermo, Italy., Italy.

In recent years, a new gluten- or wheat-related disease has emerged, a condition labelled "non-celiac gluten sensitivity" (NCGS) or "non-celiac wheat sensitivity" (NCWS). NCWS pathogenesis is still uncertain and attributed to very different mechanisms. We aimed to study the different T lymphocyte subsets in the rectal mucosa of NCWS patients, to demonstrate the possible contribution of adaptative immune response. Read More

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http://dx.doi.org/10.1152/ajpgi.00104.2020DOI Listing

Breast-Milk Microbiota Linked to Celiac Disease Development in Children: A Pilot Study From the PreventCD Cohort.

Front Microbiol 2020 23;11:1335. Epub 2020 Jun 23.

Microbial Ecology, Nutrition and Health Research Unit, Institute of Agrochemistry and Food Technology, Spanish National Research Council, Valencia, Spain.

Celiac disease (CeD) is an immune-mediated disorder triggered by exposure to dietary gluten proteins in genetically predisposed individuals. In addition to the host genome, the microbiome has recently been linked to CeD risk and pathogenesis. To progress in our understanding of the role of breast milk microbiota profiles in CeD, we have analyzed samples from a sub-set of mothers ( = 49) included in the PreventCD project, whose children did or did not develop CeD. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324710PMC

Intestinal Ca absorption revisited: A molecular and clinical approach.

World J Gastroenterol 2020 Jun;26(24):3344-3364

Laboratorio "Dr. Fernando Cañas", Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba 5000, Argentina.

Ca has an important role in the maintenance of the skeleton and is involved in the main physiological processes. Its homeostasis is controlled by the intestine, kidney, bone and parathyroid glands. The intestinal Ca absorption occurs mainly the paracellular and the transcellular pathways. Read More

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http://dx.doi.org/10.3748/wjg.v26.i24.3344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327788PMC

Celiac Disease and Portal Hypertension: A Causal Association or Just a Coincidence?

J Clin Exp Hepatol 2020 Jul-Aug;10(4):290-295. Epub 2019 Nov 22.

Department of Gastroenterology, SMS Medical College and Hospital, Jaipur, India.

Introduction: Celiac disease (CD) has been linked to portal hypertension (PHT) of varied etiology, but the causality association has never been proved. We aim to study the prevalence of CD in patients of PHT of different etiology.

Methods: A prospective observational study was conducted from June 2017 to December 2018 involving all the cases of PHT of varied etiology. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335706PMC
November 2019

Enteric-Release Budesonide May Be Useful in the Management of Non-Responsive Celiac Disease.

Dig Dis Sci 2020 Jul 11. Epub 2020 Jul 11.

Celiac Research Program, Harvard Medical School, Boston, USA.

Background: Non-responsive celiac disease (NRCD) has many aetiologies, including gluten exposure. Budesonide may be used for refractory celiac disease (RCD) and celiac crisis.

Aims: We reviewed the effectiveness of budesonide to induce clinical and histologic response in NRCD with villous atrophy (VA). Read More

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http://dx.doi.org/10.1007/s10620-020-06454-5DOI Listing

Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg.

J Pediatr Endocrinol Metab 2020 Jul 13. Epub 2020 Jul 13.

Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

Background The coexistence of celiac disease (CD) and obesity/overweight is not unusual. Objective We investigate the prevalence and clinical presentation of CD, detected by screening, among children with excessive weight gain. Methods We enrolled 200 children referred for overweight/obesity to our outpatient clinic. Read More

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http://dx.doi.org/10.1515/jpem-2020-0076DOI Listing

Compositional and immunogenic evaluation of fractionated wheat beers using mass spectrometry.

Food Chem 2020 Jul 5;333:127379. Epub 2020 Jul 5.

Food Allergy Research and Resource Program, Department of Food Science and Technology, Food Innovation Center, 1901 North 21st Street, University of Nebraska-Lincoln, Lincoln, NE 68588, United States. Electronic address:

The safety and regulatory status of fermented products derived from gluten-containing grains for patients with celiac disease remains controversial. Bottom-up mass spectrometry (MS) has complemented immunoassays for the compositional and immunogenic analyses of wheat beers. However, uncharacterized proteolysis during brewing followed by the secondary digestion for MS has made the analysis and data interpretation complicated. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127379DOI Listing

Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY).

Endocrine 2020 Jul 10. Epub 2020 Jul 10.

Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.

Purpose: Autoimmune diseases co-occur, perhaps due to common risk factors. The age at gluten introduction and gluten intake in early childhood has been associated with the autoimmunity preceding celiac disease (CD) and type-1 diabetes (T1D). We explored their associations with the development of thyroid autoimmunity. Read More

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http://dx.doi.org/10.1007/s12020-020-02412-3DOI Listing

Safety of a GFD in Pregnant Women Without Celiac Disease: Investigating Ingrained Habits.

Dig Dis Sci 2020 Jul 10. Epub 2020 Jul 10.

Harvard Celiac Research Program, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10620-020-06452-7DOI Listing

X6: A Novel Antibody for Potential Use in Gluten Quantification.

Molecules 2020 Jul 8;25(14). Epub 2020 Jul 8.

Head Office, XEMA Co., Ltd., 9-th Parkovaya str., 48, 105264 Moscow, Russian.

Gliadin is a fraction of gluten, known to trigger celiac disease in susceptible people. To date, the life-long gluten-free diet is used for the prevention of this disease. Hence, methods for gluten control in foods are of significant importance. Read More

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http://dx.doi.org/10.3390/molecules25143107DOI Listing

Wheat ( L.) breeding from 1891 to 2010 contributed to increasing yield and glutenin contents but decreasing protein and gliadin contents.

J Agric Food Chem 2020 Jul 10. Epub 2020 Jul 10.

Epidemiologic studies suggest an increasing prevalence of celiac disease and nonceliac gluten/wheat sensitivity. With wheat proteins being the main triggers, changes in wheat protein composition are discussed as potential cause. The goals of breeding towards increased yield and resistance might have inadvertently contributed to a higher immunostimulatory potential of modern compared to old wheat cultivars. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c02815DOI Listing

The Dilemma Between Autoimmune Trombocytopenia and Celiac Disease.

Indian J Hematol Blood Transfus 2020 Jul 24;36(3):590-591. Epub 2020 Feb 24.

Division of Hematology, Medical Faculty, Adnan Menderes University, 09100 Aydın, Turkey.

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http://dx.doi.org/10.1007/s12288-020-01267-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326855PMC

Gastrointestinal diseases and their impact on drug solubility: Celiac disease.

Eur J Pharm Sci 2020 Jul 6;152:105460. Epub 2020 Jul 6.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. Electronic address:

The aim of this study was to develop an in vitro tool for predicting drug solubility and dissolution in intestinal fluids of patients with Celiac disease (CED). Biorelevant media for patients with CED were developed based on published information and a Design of Experiment (DoE) approach. The CED biorelevant media were characterised according to their surface tension, osmolality, dynamic viscosity and buffer capacity. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105460DOI Listing

Characteristics and etiologies of short stature in children: Experience of an endocrine clinic in a Tunisian tertiary care hospital.

Int J Pediatr Adolesc Med 2020 Jun 4;7(2):74-77. Epub 2019 Jul 4.

Université de Tunis El Manar, Faculté de Médecine de Tunis, 1007, Tunis, Tunisia.

Background: Short stature is a common reason for referral to pediatric endocrinology clinics. It may be a manifestation of a pathological condition requiring early treatment. The aim of this study was to describe the characteristics and etiologies of short stature among children referred to the pediatric endocrinology clinic of the main pediatric tertiary care center in Tunisia. Read More

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http://dx.doi.org/10.1016/j.ijpam.2019.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335824PMC

Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk.

Cancer Res 2020 Jul 8. Epub 2020 Jul 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute

Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (+/- 500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-20-0447DOI Listing

Black Race and Public Insurance Are Predictive of Inappropriate Evaluation of Iron Deficiency Anemia and Diarrhea.

Dig Dis Sci 2020 Jul 7. Epub 2020 Jul 7.

Section of Gastroenterology, Hepatology and Nutrition, The University of Chicago Medicine, 5841 S. Maryland Ave. MC 4076, Chicago, IL, 60637, USA.

Background And Aims: Socioeconomic status, race, and insurance can impact healthcare delivery and utilization in several chronic disease states. The primary aim of our study was to determine whether race and insurance status are predictors of having an appropriate workup for celiac disease and inflammatory bowel disease (IBD) when presenting with iron deficiency anemia (IDA) and chronic diarrhea.

Methods: Medical records of patients seen at the University of Chicago Medical Center between January 1, 2006, and September 20, 2017, were reviewed. Read More

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http://dx.doi.org/10.1007/s10620-020-06434-9DOI Listing

Celiac Disease Diagnosed in an Older Adult Patient with a Complex Neuropsychiatric Involvement: A Case Report and Review of the Literature.

Brain Sci 2020 Jul 3;10(7). Epub 2020 Jul 3.

Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, via Álvaro del Portillo 200, 00128 Rome, Italy.

We present a case of celiac disease (CD) diagnosis in a 75-year-old woman with a long-term history of chronic delusional jealousy and a complex neurological involvement. The case describes a very unusual clinical picture, provides some clinical clues, and highlights the importance of being aware of CD extraintestinal manifestations in order to get a timely diagnosis. Read More

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http://dx.doi.org/10.3390/brainsci10070426DOI Listing

Gold nanoparticles phytoreduced with Cornus mas extract mitigate some of gliadin effects on Caco-2 cells.

J Physiol Pharmacol 2020 Apr 2;71(2). Epub 2020 Jul 2.

Department of Gastroenterology and Hepatology, Regional Institute of Gastroenterology and Hepatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Celiac disease (CD) is an autoimmune condition that occurs in genetically predisposed people where the ingestion of gluten produces damage in the small intestine. The treatment accepted until now is a strict gluten free diet. This implies the need for novel or adjuvant treatments, in addition to the standard of care. Read More

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http://dx.doi.org/10.26402/jpp.2020.2.04DOI Listing

Evaluation of Anti-Inflammatory and Atheroprotective Properties of Wheat Gluten Protein Hydrolysates in Primary Human Monocytes.

Foods 2020 Jun 30;9(7). Epub 2020 Jun 30.

Department of Food & Health, Instituto de la Grasa, CSIC, Ctra. de Utrera Km. 1, 41013 Seville, Spain.

Bioactive protein hydrolysates have been identified in several sources as possible agents in the prevention and treatment of many diseases. A wheat gluten (WG) concentrate was hydrolyzed by Alcalase under specific conditions. The resulting hydrolysates were evaluated by in vitro cell-free experiments leading to the identification of one bioactive WG protein hydrolysate (WGPH), which was used at 50 and 100 μg/mL on primary human monocytes. Read More

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http://dx.doi.org/10.3390/foods9070854DOI Listing

A not so common cause of iron deficiency in inflammatory bowel disease.

Am J Med 2020 Jul 3. Epub 2020 Jul 3.

Insitute of Pathology Saarbrücken-Rastpfuhl, Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.05.037DOI Listing

Immune Checkpoint Inhibitor-Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Gastritis and Celiac Disease.

Arch Pathol Lab Med 2020 Jul 6. Epub 2020 Jul 6.

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Immune checkpoint inhibitor (CPI) therapies are associated with multi-organ immune-related adverse events. Although colonic mucosal changes have been described, inflammatory changes incited by CPIs in the upper gastrointestinal tract have not been well characterized. Read More

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http://dx.doi.org/10.5858/arpa.2019-0700-OADOI Listing

Case Report: Virtual and Interactive 3D Vascular Reconstruction Before Planned Pancreatic Head Resection and Complex Vascular Anatomy: A Bench-To-Bedside Transfer of New Visualization Techniques in Pancreatic Surgery.

Front Surg 2020 18;7:38. Epub 2020 Jun 18.

University Hospital for Visceral Surgery, Pius-Hospital, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Bühler's anastomosis (or Bühler's arcade) is an embryonic relic and represents an arterio-arterial connection between the superior mesenteric artery and the celiac trunk. It can be found as a variety in 1-2% of patients. We present a case of a patient with metatastatic squamous cell carcinoma of the lung. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314924PMC

Effect of wheat grain protein composition on end-use quality.

J Food Sci Technol 2020 Aug 4;57(8):2771-2785. Epub 2020 Jan 4.

Department of Biotechnology, Akal College of Agriculture, Eternal University, Baru Sahib, 173101 Himachal Pradesh India.

The quality of wheat products has been a new challenge next to wheat production which was achieved substantially during green revolution. The end-use quality of wheat is an essential factor for its commercial demand. The quality of wheat is largely based on the wheat storage proteins which extensively influences the dough properties. Read More

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http://dx.doi.org/10.1007/s13197-019-04222-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316921PMC

Nesidioblastosis Associated with Pancreatic Heterotopia as a Differential Diagnosis of Hypoglycemia: A Literature Review and Case Report.

Am J Case Rep 2020 Jul 6;21:e922778. Epub 2020 Jul 6.

Division of Endocrinology and Diabetes, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, PE, Brazil.

BACKGROUND Nesidioblastosis is a rare disease that is part of the differential diagnosis of pancreatogenic hyperinsulinemic hypoglycemia (PHH) in patients whose imaging studies do not localize insulinoma. Pancreatic heterotopia is a rare congenital abnormality characterized by pancreatic tissue anatomically separated from the main gland and found in 0.5% of abdominal surgeries. Read More

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http://dx.doi.org/10.12659/AJCR.922778DOI Listing

Correction to: Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?

Dig Dis Sci 2020 Jul 4. Epub 2020 Jul 4.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Virginia, MR-4 Bldg, 409 Lane Rd., Charlottesville, VA, 22908, USA.

The original version of the article is unfortunately missing the funding information. Funding note is given below. Read More

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http://dx.doi.org/10.1007/s10620-020-06453-6DOI Listing

Saudi children with celiac disease: are they at risk of developing type-1 diabetes mellitus?

J Pediatr Endocrinol Metab 2020 Jul 5. Epub 2020 Jul 5.

Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Objectives Patients with type-1 diabetes mellitus (T1DM) and celiac disease (CeD) share the same genetic susceptibility alleles. The diabetes-associated autoantibodies (DAA) may be detected in CeD patients. The aim of this study is to describe the prevalence of DAA in children with CeD. Read More

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http://dx.doi.org/10.1515/jpem-2019-0588DOI Listing
July 2020
0.711 Impact Factor

Williams-Beuren Syndrome and celiac disease: A real association?

Eur J Med Genet 2020 Jul 2:103999. Epub 2020 Jul 2.

Department of Pediatric, ASST-Lariana, Sant'Anna Hospital, San Fermo Della Battaglia (Como), Italy.

Celiac disease (CD) screening in patients with Williams-Beuren Syndrome (WBS) is suggested, although data described in literature are discordant regarding CD prevalence in WBS. We retrospectively collected data from 101 WBS Italian patients [mean age: 13.5 years], to clarify the CD prevalence in a large cohort. Read More

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http://dx.doi.org/10.1016/j.ejmg.2020.103999DOI Listing

Delays in colonoscopy start time are associated with reductions in adenoma detection rates.

Dig Liver Dis 2020 Jul 1. Epub 2020 Jul 1.

Celiac Disease Center, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

Background: Prior investigations of the impact of case delays on adenoma detection rates have not found a significant association, though these studies included modest delays, with few cases delayed by more than one hour.

Aims: The aim of this study was to measure the impact of prolonged case delays on the colonoscopy outcome measures of adenoma detection rate and withdrawal time.

Methods: We performed a single center cohort study including patients aged ≥50 years undergoing screening colonoscopy during a 4. Read More

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http://dx.doi.org/10.1016/j.dld.2020.06.011DOI Listing

Prevalence of celiac disease in patients with short stature: A systematic review and Meta-analysis.

J Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Gastroenterology and Human nutrition, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Aim/background: Short stature is a common extra-intestinal manifestation of celiac disease (CeD). We conducted a systematic review and meta-analysis to assess the global prevalence of CeD in patients presenting with short stature.

Methods: We searched Medline and EMBASE databases for the keywords 'celiac disease, coeliac disease, anti-gliadin, tissue transglutaminase antibody, anti-endomysial antibody, short stature and growth retardation'. Read More

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http://dx.doi.org/10.1111/jgh.15167DOI Listing

Celiac disease screening in children and adolescents with type1 diabetes mellitus: What test should be performed?

Endocrinol Diabetes Nutr 2020 Jun 30. Epub 2020 Jun 30.

Unidad de Gastroenterología, Servicio de Pediatría, Hospital Universitario Ramón y Cajal. Departamento de Medicina y Especialidades Médicas, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, España.

Introduction: Children and adolescents with type1 diabetes mellitus (T1DM) are at high risk for the development of celiac disease (CD) because of the common genetic characteristics of both conditions. The study objectives were to investigate the frequency of the human leukocyte antigen system (HLA) for CD in pediatric T1DM patients and to determine whether HLA testing is suitable for CD screening in that population and is cost-effective as compared to serological screening for CD.

Patients And Methods: A retrospective, descriptive study was conducted in 296 patients (148 girls; 148 boys) with T1DM aged <18years who attended a hospital in Madrid. Read More

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http://dx.doi.org/10.1016/j.endinu.2020.03.007DOI Listing

Template-based peptide modeling for celiac risk assessment of newly expressed proteins in GM crops.

Regul Toxicol Pharmacol 2020 Jun 30:104715. Epub 2020 Jun 30.

Corteva Agriscience™, United States.

Newly expressed proteins in genetically modified (GM) crops are subject to celiac disease risk assessment according to EFSA guidelines. Amino acid identity matches between short peptides (9aa) and known celiac restricted epitopes are required to be further evaluated through peptide modeling; however, validated methods and criteria are not yet available. In this investigation, several structures of HLA-DQ2. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104715DOI Listing

Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century.

Am J Gastroenterol 2020 Jul;115(7):1117-1124

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Introduction: We assessed whether celiac disease-associated mortality is increased in Finland among patients diagnosed in the 21st century, given recent improvements in diagnostic and treatment facilities.

Methods: Biopsy-proven patients with celiac disease (Marsh III) and dermatitis herpetiformis aged 20-79 years (median 50 years) diagnosed 2005-2014 (n = 12,803) were identified from the national dietary grant registry. Dates and causes of death were obtained from Statistics Finland. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000665DOI Listing

The Gluten-Free Family Ripple Effect: The Tides that Bond and the Tides that Divide.

Dig Dis Sci 2020 Jul 2. Epub 2020 Jul 2.

Harvard Celiac Research Program, Boston Children's Hospital, Boston, MA, 0211, USA.

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http://dx.doi.org/10.1007/s10620-020-06428-7DOI Listing

Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes.

Acta Diabetol 2020 Jul 2. Epub 2020 Jul 2.

Diabetes Research Institute, IRCCS San Raffaele Hospital, 20132, Milan, Italy.

Aims: A higher SGLT1 and GLUT2 gene expression was shown in the intestine of subjects with type 2 diabetes, while no data have been reported in type 1 diabetes (T1D). The purpose of our study was to evaluate the expression of glucose transporters in duodenal mucosa of subjects with T1D, compared to healthy controls (CTRL) and to patients with celiac disease (CD), as gut inflammatory disease control group.

Materials And Methods: Gene expression of GLUT1, GLUT2, SGLT1 and SGLT2 was quantified on duodenal mucosa biopsies of subjects with T1D (n = 19), CD (n = 16), T1D and CD (n = 6) and CTRL (n = 12), recruited at San Raffaele Hospital (Milan, Italy), between 2009 and 2018. Read More

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http://dx.doi.org/10.1007/s00592-020-01558-wDOI Listing

Haemophagocytic lymphohistiocytosis after heart transplantation: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-4. Epub 2020 May 3.

Department of Transplant Institute, Sahlgrenska University Hospital, SE-413 25, Gothenburg, Sweden.

Background: Haemophagocytic lymphohistiocytosis (HLH) is an uncommon but serious systemic inflammatory response with high mortality rates. It can be triggered by malignancy or infectious agents, often in the context of immunosuppression. Literature covering HLH in heart transplantation (HTx) is scarce. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319853PMC

Celiac autoantibody positivity in relation to clinical characteristics in children with type 1 diabetes.

J Clin Transl Res 2020 Apr 19;5(3):91-95. Epub 2020 Feb 19.

University Diabetes Center, King Abdulaziz University Hospital, King Saud University, Riyadh, Saudi Arabia.

Background: Type 1 diabetes is an autoimmune disorder with a high risk of celiac disease (CD).

Aim: This study aimed to determine the celiac autoantibody status and the clinical characteristics among children with type 1 diabetes and autoantibody positivity for CD compared to those without serological evidence of CD.

Materials And Methods: In this cross-sectional study, 240 children with type 1 diabetes underwent serological screening CD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326273PMC

A Ligamentous Agony: Median Arcuate Ligament Syndrome as an Under-Recognized Cause of Abdominal Pain.

Cureus 2020 Jun 27;12(6):e8865. Epub 2020 Jun 27.

Internal Medicine, Rochester General Hospital, Rochester, USA.

Median arcuate ligament (MAL) syndrome (MALS) is a rare clinical entity characterized by chronic abdominal pain resulting from compression of the celiac artery by the MAL. We present a case of MALS with imaging evidence of anterior compression of the celiac artery on expiration, which was relieved on inspiration. A 33-year-old woman presented with intermittent upper abdominal pain since three months. Read More

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http://dx.doi.org/10.7759/cureus.8865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325387PMC

Deciphering short stature in children.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):69-79. Epub 2020 Jun 30.

Department of Pediatrics, University of Chieti, Chieti, Italy.

Short stature is a common reason for referral to pediatric endocrinologists. Multiple factors, including genetic, prenatal, postnatal, and local environmental factors, can impair growth. The majority of children with short stature, which can be defined as a height less than 2 standard deviation score below the mean, are healthy. Read More

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http://dx.doi.org/10.6065/apem.2040064.032DOI Listing

Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients.

Infect Drug Resist 2020 24;13:1961-1970. Epub 2020 Jun 24.

Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Background: Extended-spectrum ß-lactamase (ESBL)-producing and are the most common uropathogens causing UTI (urinary tract infection) in type 2 diabetes mellitus (T2DM). Circulatory inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are usually dysregulated during UTI. However, the differential regulation of these inflammatory signatures during and UTI in T2DM has not been determined. Read More

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http://dx.doi.org/10.2147/IDR.S251966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323571PMC

mTOR sustains inflammatory response in celiac disease.

Sci Rep 2020 Jul 1;10(1):10798. Epub 2020 Jul 1.

Department of Systems Medicine, University of "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.

Celiac disease (CD) is an enteropathy triggered by the ingestion of gluten proteins in genetically predisposed individuals and characterized by excessive activation of effector immune cells and enhanced production of inflammatory cytokines. However, factors/mechanisms that amplify the ongoing mucosal inflammation in CD are not fully understood. In this study, we assessed whether mammalian target of Rapamycin (mTOR), a pathway that combines intra- and extra-cellular signals and acts as a central regulator for the metabolism, growth, and function of immune and non-immune cells, sustains CD-associated immune response. Read More

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http://dx.doi.org/10.1038/s41598-020-67889-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329835PMC

[Analysis of the leading pathogenetic factors of dental caries in children with celiac disease].

Stomatologiia (Mosk) 2020 ;99(3):71-73

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

The Aim: To identify the leading pathogenetic factors of dental caries in children with celiac disease.

Material And Methods: The study included 48 children with a confirmed diagnosis of celiac disease at the age of 8-16 years. All the children were examined by a dentist, the oral cavity was sanitized, recommendations for oral care were given. Read More

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http://dx.doi.org/10.17116/stomat20209903171DOI Listing

Living with Gluten and Other Food Intolerances: Self-Reported Diagnoses and Management.

Nutrients 2020 Jun 26;12(6). Epub 2020 Jun 26.

Division of Sciences and Engineering, Department of Chemical, Biological and Agricultural Sciences, Clinical and Research Laboratory (LACIUS, URS), University of Sonora, Navojoa, Sonora 85880, Mexico.

People suffering from a food intolerance (FI) tend to initiate restrictive diets such as a gluten-free diet (GFD), to alleviate their symptoms. To learn about how people live with these problems in daily life (independent of their medical diagnoses), 1203 participants answered a previously validated questionnaire and were divided into: G1 (those self-reporting symptoms after gluten consumption) and G2 (those informing no discomfort after gluten consumption). Self-reported clinical characteristics, diagnoses and diets followed were registered. Read More

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http://dx.doi.org/10.3390/nu12061892DOI Listing

Prevalence of auto-antibodies and autoimmune disorders in patients with celiac disease.

Scand J Gastroenterol 2020 Jun 30. Epub 2020 Jun 30.

All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1080/00365521.2020.1785544DOI Listing

Nutritional management of celiac crisis in an elderly adult: A case report of the rare presentation of celiac disease in a 75-y-old woman.

Nutrition 2020 May 19;79-80:110858. Epub 2020 May 19.

Unit of Dietetic and Clinical Nutrition, University Hospital Maggiore della Carità, Novara, Italy.

In adults, a very uncommon presentation of celiac disease (CD) is a celiac crisis, a life-threatening and severe form of the disease having a dramatic onset with diarrhea and metabolic acidosis with electrolyte and fluid imbalance. Treatment of celiac crisis requires a gluten-free diet; however, the risk for refeeding syndrome (RFS) should be considered in patients showing marked malabsorption symptoms and important unintentional weight loss. Therefore, to avoid metabolic and potentially fatal complications of re-nutrition, nutritional management is crucial for a safe recovery after a celiac crisis. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110858DOI Listing

[Chronic pancreatitis with IBS-like syndrome: approach to therapy].

Ter Arkh 2020 Apr 27;92(2):61-66. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome.

Materials And Methods: 312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000518DOI Listing

The Epidemiology of Celiac Disease in the General Population and High-Risk Groups in Arab Countries: A Systematic Review.

Biomed Res Int 2020 3;2020:6865917. Epub 2020 Jun 3.

King Abdulaziz Medical City, National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background And Aims: Celiac disease (CD) is possibly the most common autoimmune disorder, which may lead to dietary problems in the Arab region. This paper is aimed at exploring the epidemiology of the celiac disease in Arab countries, including its prevalence, associated risk factors, and clinical patterns.

Methods: An extensive search of the literature was conducted from electronic databases such as PubMed, Embase, and Google Scholar. Read More

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http://dx.doi.org/10.1155/2020/6865917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292982PMC