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JFMS Open Rep 2019 Jan-Jun;5(1):2055116919840810. Epub 2019 Mar 29.

Department of Veterinary Medicine and Surgery, Rural Federal University of Rio de Janeiro, Seropédica, Brazil.

Case Summary: It is described a case of a 10-month-old female mixed-breed cat with left ear discharge of approximately 6 days' duration prior to the admission. Secretions were collected from both ears using a sterile swab for cytological and mycological analysis. A pyogranulomatous inflammatory infiltrate (predominantly characterized by the presence of neutrophils and macrophages) with the presence of cocci, rods and many yeast-like structures were seen on cytological analysis; the fungal culture confirmed the presence of the complex. Read More

Med Mycol 2019 Mar 30. Epub 2019 Mar 30.

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory of Infectious Disease Prevention and Control, Beijing, China.

Sporothrix globosa is an important clinical pathogen in the Sporothrix complex, which is causing sporotrichosis. S. globosa is distributed worldwide, especially in Asia. Read More

Am J Med 2019 Mar 20. Epub 2019 Mar 20.

University of Oklahoma Health Sciences Center, College of Medicine, Department of Internal Medicine, Division of Rheumatology.

Braz J Microbiol 2019 Mar 14. Epub 2019 Mar 14.

Departamento de Microbiologia e Imunologia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, MG, CEP 37130-001, Brazil.

In the article mentioned above an author's name was misspelled. The correct author name reads as follows: Leila Maria Lopes-Bezerra. We apologize for the inconvenience. Read More

Front Pharmacol 2019 27;10:160. Epub 2019 Feb 27.

Department of Emergency, The First Hospital of Jilin University, Changchun, China.

Antifungal therapy is used to treat sporotrichosis. However, there are several limitations in this therapy, such as development of drug resistance and potential health risks including liver injury. The purpose of our study was to evaluate the antifungal efficacy of antibody against the hybrid phage nanofibers displaying KPVQHALLTPLGLDR (phage-KR) in a fungal-infected mouse model. Read More

Molecules 2019 Mar 7;24(5). Epub 2019 Mar 7.

Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói-RJ 24241-000, Brazil.

Sporotrichosis is a neglected fungal infection caused by spp., which have a worldwide distribution. The standard antifungal itraconazole has been recommended as a first-line therapy. Read More

Vet Clin Pathol 2019 Mar 12;48(1):143-147. Epub 2019 Mar 12.

Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine, University of São Paulo, São Paulo, SP, Brazil.

Background: Sporotrichosis is an emerging zoonotic mycosis that presents as a cutaneous lymphatic or disseminated disease, caused by fungi from the Sporothrix schenkii (S schenkii) clinical clade. Its importance is growing, primarily due to an outbreak that occurred in Brazil, affecting mainly cats and people.

Objectives: In Brazil, an S schenkii diagnosis is often made using cultures, which allows genus identification and sufficient growth to perform molecular biology testing. Read More

Front Microbiol 2019 25;10:284. Epub 2019 Feb 25.

Life and Health Sciences Research Institute (ICVS), School of Medicine, Braga, Portugal.

The pathogenic clade of the genus comprises the etiological agents of sporotrichosis, a worldwide emergent disease. Despite the growing understanding of their successful pathogen traits, there is little information on genome sizes and ploidy within the genus. Therefore, in this work, we evaluated the ploidy of four species of the genus, specifically , , , and . Read More

Future Microbiol 2019 Mar 11;14:397-410. Epub 2019 Mar 11.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P. 36050, Guanajuato, Gto., México.

Aim: Sporothrix schenckii is the causative agent of sporotrichosis. A 70-kDa glycoprotein, Gp70, is a candidate for the development of prophylactic alternatives to control the disease, and its gene (GP70) is predicted to encode for a protein of 43 kDa, contrasting with the molecular weight of the native protein.

Materials & Methods: The GP70 was expressed in bacteria, the recombinant protein purified, used in immunoassays and injected to Galleria mellonella. Read More

Rev Iberoam Micol 2019 Mar 4. Epub 2019 Mar 4.

Clínica Médica, Palmeira das Missões, Brazil.

Background: Sporotrichosis is a fungal disease caused by the Sporothrix schenckii species complex. It is usually acquired by trauma with plants. Lymphatic-cutaneous is the most common clinical manifestation. Read More

PLoS Negl Trop Dis 2019 02 28;13(2):e0007219. Epub 2019 Feb 28.

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory of Infectious Disease Prevention and Control, Beijing, China.

The accurate diagnosis of sporotrichosis and identification at the species level are critical for public health and appropriate patient management. Compared with morphological identification methods, molecular diagnostic tests are rapid and have high sensitivity and standardized operating processes. Therefore, we designed a novel multiplex real-time polymerase chain reaction (PCR) method based on the calmodulin (CAL) gene for the identification of clinically relevant Sporothrix species: S. Read More

Rev Iberoam Micol 2019 Jan - Mar;36(1):17-23. Epub 2019 Feb 22.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S/N, 36050 Guanajuato, GTO, Mexico. Electronic address:

Background: Sporotrichosis is a fungal infection caused by the Sporothrix schenckii complex. In order to colonize the host, the pathogen must neutralize the reactive oxygen species produced by the phagocytic cells during the respiratory burst. Little is known about these mechanisms in S. Read More

N Engl J Med 2019 Feb;380(8):771

Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China

S D Med 2018 Nov;71(11):512-513

Department of Internal Medicine, Rapid City Regional Hospital.

Sporotrichosis is typically seen as a cutaneous infection, resulting from inoculation of the fungus, Sporothrix schenckii. This fungus is typically found on the thorns of rose bushes in lush, humid environments, and the pathogen enters the body via breaches in the skin barrier. Read More

Med Mycol Case Rep 2019 Mar 16;23:72-76. Epub 2019 Jan 16.

National Mycology Reference Centre, Microbiology and Infectious Diseases, SA Pathology, Frome Road, Adelaide SA 5000, Australia.

A nine-year-old domestic cat from Melbourne, Australia, presented with a non-ulcerated nodule on its nasal bridge. A fungal infection of the subcutis was diagnosed based on histopathology and culture of a white mould, which was identified as complex by ITS1-5.8S-ITS2 and β-tubulin gene sequencing. Read More

Microb Pathog 2019 Apr 30;129:56-63. Epub 2019 Jan 30.

Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad No. 940, Aguascalientes, AGS, Mexico. Electronic address:

Histopathological studies of human sporotrichosis lesions show pyogenic and granulomatous processes in which polymorphonuclear neutrophils (PMNs) play a central role. Few studies regarding the events associated with the interaction of human PMNs with Sporothrix schenckii have been made despite their importance in the clinical manifestations of the disease. In this study, human PMNs were co-cultured with conidia or yeast cells of S. Read More

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Universidad Nacional Mayor de San Marcos, Lima Department of Dermatology, Hospital Nacional Dos de Mayo, Lima.

Sporotrichosis is a subcutaneous mycosis caused by Sporothrix schenckii with endemic regions in the American continent. Clinical features depend on the immunological patient state and some characteristics of the fungus. Disseminated cutaneous sporotrichosis is a rare variant usually described in immunocompromised patients. Read More

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

Dermatol Surg 2019 Jan 17. Epub 2019 Jan 17.

Dermatologic Surgery Unit, Bonsucesso Federal Hospital, Rio de Janeiro, Brazil Dermatology DepartmentBonsucesso Federal Hospital, Rio de Janeiro, Brazil Laboratory of Clinical Research in Infectious DermatologyEvandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Med Mycol 2019 Jan 16. Epub 2019 Jan 16.

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

Sporotrichosis is a subcutaneous mycosis caused by traumatic inoculation of pathogenic Sporothrix species. Until recently, Sporothrix globosa was considered as the unique Chinese species causing this disorder. In the present study, 33 clinical Sporothrix strains isolated from Jiangxi, China, were classified and antifungal susceptibility for each strain was determined. Read More

Infect Drug Resist 2019 28;12:67-85. Epub 2018 Dec 28.

Department of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico,

Background: is a neglected fungal pathogen for the human being and other mammals. In several fungal systems, Och1 is a Golgi α1,6-mannosyltransferase with a key function in the synthesis of -linked glycans; which are important elements during the host-fungus interplay. The role of in fungal virulence seems to be species-specific, being an essential component for virulence and dispensable during the interaction of with the host. Read More

J Fungi (Basel) 2019 Jan 11;5(1). Epub 2019 Jan 11.

Laboratory of Medical Mycology, Department of Dermatology, and Tropical Medicine Institute, University of São Paulo, Sao Paulo 05403-000, Brazil.

Sporotrichosis is a global implantation or subcutaneous mycosis caused by several members of the genus , a thermo-dimorphic fungus. This disease may also depict an endemic profile, especially in tropical to subtropical zones around the world. Interestingly, sporotrichosis is an anthropozoonotic disease that may be transmitted to humans by plants or by animals, especially cats. Read More

Braz J Microbiol 2019 Jan 13;50(1):139-145. Epub 2018 Dec 13.

Departamento de Microbiologia e Imunologia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, MG, CEP 37130-001, Brazil.

Sporotrichosis is an infection of the skin caused by traumatic inoculation of the fungus Sporothrix schenckii. Definitive diagnosis relies on direct visualization of the fungus or its isolation on culture medium, although both have low sensitivity. Alternatively, the detection of the antibody response offers a more rapid alternative for diagnosis. Read More

Med Mycol Case Rep 2019 Mar 21;23:46-49. Epub 2018 Dec 21.

Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, 50 Paholyothin Road, Ladyao, Chatuchak, Bangkok 10900, Thailand.

This is a case report of feline sporotrichosis in a 3-year-old male intact DSH stray cat in Bangkok, Thailand. Cytology and histopathology revealed yeast-like organisms in ulcerative cutaneous lesions. Fungal culture and sequence analysis of ITS region of rDNA confirmed the diagnosis and the causative agent as This is the first case report of feline sporotrichosis in the country. Read More

Am J Trop Med Hyg 2019 Mar;100(3):706-713

Postgraduate Program in Infectious Diseases, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.

This study discusses a historical patient series and is designed to describe clinical and epidemiological characteristics of human sporotrichosis in the state of Espírito Santo, Brazil. Data were derived from patients treated at the Infectious Diseases service of Cassiano Antônio Moraes University Hospital in Vitória, the state capital, from July 1982 to June 2012. A total of 171 patients were diagnosed with sporotrichosis, mostly men (80. Read More

Rev Salud Publica (Bogota) 2018 Mar-Apr;20(2):198-203

DF: MV. Ph. D. Em Medicina Veterinária Universidade Brasil. Fernandópolis, Brasil.

Objectives : To assess knowledge about zoonoses in dog and cat owners.

Materials And Methods : After applying a questionnaire to 100 owners, data was analyzed by calculating simple means and quantifiable percentage.

Results : 77% of the sample owned dogs and 37% cats. Read More

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Infectious Dermatology Clinical Research Laboratory, Rio de Janeiro, Brazil.

Mycopathologia 2019 Feb 15;184(1):53-63. Epub 2018 Dec 15.

Grupo de Investigación Dermatológica, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Carrera 51D No. 62-29, Oficina 303, Edificio Manuel Uribe Angel, Medellín, Colombia.

Background: Sporotrichosis is a subcutaneous mycosis that affects humans and other animals. Infection prevails in tropical and subtropical countries. Until a few years ago, it was considered that two varieties of Sporothrix schenckii caused this mycosis, but by applying molecular taxonomic markers, it has been demonstrated that there are several cryptic species within S. Read More

Cureus 2018 Oct 8;10(10):e3428. Epub 2018 Oct 8.

Ophthalmology, School of Medical Sciences/Universiti Sains Malaysia, Kota Bharu, MYS.

In human, sporotrichosis infection commonly manifests as skin lesions through direct inoculation. It is rarely associated with ocular manifestation via a zoonotic transmission. We describe a young lady who presented with acute left eye granulomatous conjunctivitis who had a history of exposure to her sick cat diagnosed with sporotrichosis infection. Read More

J Med Microbiol 2019 Feb 13;68(2):248-254. Epub 2018 Dec 13.

1​State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, PR China.

Purpose: Sporothrix globosa is the most important agent of sporotrichosis in China. The aim of this study is to investigate the population parameters of S. globosa. Read More

J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China.

J Emerg Med 2019 Feb 6;56(2):222-223. Epub 2018 Dec 6.

Instituto de Dermatologia Prof. Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil.

Case Rep Dermatol 2018 Sep-Dec;10(3):231-237. Epub 2018 Oct 24.

Sector of Dermatology and Post-Graduation Course, HUCFF-UFRJ and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Sporotrichosis is an infection caused by fungi of the complex. The clinical lymphocutaneous presentation corresponds to the great majority of cases. With the increased incidence of sporotrichosis in the State of Rio de Janeiro, Brazil, atypical clinical forms have been reported with increasing frequency, usually associated with immunosuppression. Read More

Indian J Dermatol 2018 Nov-Dec;63(6):496-501

Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Subcutaneous mycoses, although rare, are frequently reported from northeast India. Their spectrum varies with geographic region.

Materials And Methods: We evaluated clinical records and histopathological features of subcutaneous mycoses cases seen during April 2013 to March 2017. Read More

PLoS One 2018 30;13(11):e0207644. Epub 2018 Nov 30.

Clinical Laboratory and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Feline sporotrichosis due to Sporothrix brasiliensis is frequently severe and often correlated to zoonotic transmission. Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) cause immunodeficiency in cats; no association has been identified with critical cases of sporotrichosis. Moreover, the cytokine profile in Sporothrix-infected cats and a potential impact of retrovirus co-infections on their immunity is unknown. Read More

An Bras Dermatol 2018 Nov/Dec;93(6):907-909

Service of Dermatology and Department of Mycology, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, Mexico.

We report 73 cases of cutaneous sporotrichosis from the Community Dermatology program, at the central and mountain areas of the state of Guerrero, Mexico. A similar number of cases was found between children and adults, mostly peasants and school-age children with rural occupations. Upper limbs were the mostly affected and the predominant clinical form was lymphocutaneous (56. Read More

Med Mycol Case Rep 2019 Mar 12;23:16-19. Epub 2018 Nov 12.

Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, 20270-004 Rio de Janeiro, Brazil.

Sporotrichosis is a human and animal disease caused by dimorphic pathogenic species of the genus . We report a dramatic presentation of infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Read More

J Med Microbiol 2019 Jan 19;68(1):87-94. Epub 2018 Nov 19.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brazil, Avenida Professor Lineu Prestes, 580, São Paulo, 05508-000, Brazil.

Purpose: Sporothrix brasiliensis, a member of the Sporothrix schenckii complex, is a major cause of epidemic outbreaks of sporotrichosis due to its greater virulence and ability to evade the immune system. The absence of studies about this species led to this study, with the aim to evaluate the importance of Toll-like receptor-2 (TLR-2) during S. brasiliensis infection. Read More

Fungal Biol 2018 12 24;122(12):1163-1170. Epub 2018 Aug 24.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, SP, Brazil. Electronic address:

Little is known about the differences in the CD4+ T-cell response induced by Sporothrix schenckii and Sporothrix brasiliensis, the most virulent species that cause sporotrichosis. Here, the helper (Th) and regulatory T cells (Tregs) responses were evaluated comparatively in a murine model of sporotrichosis on days 7, 21 and 35 after subcutaneous infection with either S. schenckii or S. Read More

Cureus 2018 Aug 23;10(8):e3196. Epub 2018 Aug 23.

Dermatologist, San Diego Family Dermatology, San Diego, USA.

Sporotrichosis is a fungal infection known for its distinct pattern of infectious skin nodules. Several conditions can present with lesions that appear in a sporotrichoid pattern. An 82-year-old man that presented with three cutaneous nodules on his right leg in a sporotrichoid manner is described; biopsy of each lesion revealed a keratoacanthoma. Read More

J Clin Microbiol 2018 Nov 25;56(11). Epub 2018 Oct 25.

Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany

J Clin Microbiol 2018 Nov 25;56(11). Epub 2018 Oct 25.

Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany

Am J Dermatopathol 2018 Nov;40(11):861

Pathology, University of Colorado School of Medicine, Aurora, CO.

Front Microbiol 2018 2;9:2286. Epub 2018 Oct 2.

Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, Brazil.

Sporotrichosis is a mycosis that affects the skin, lymphatic system and other organs in humans and animals. The disease has a worldwide distribution, with endemic areas in Brazil, and is caused by a complex of species, including . Some fungi release extracellular vesicles (EVs) that can interact with the host cell and modulate the host immune response. Read More

J Fungi (Basel) 2018 Oct 12;4(4). Epub 2018 Oct 12.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P.; Guanajuato Gto. 36050, México.

Sporotrichosis is a neglected, deep-seated fungal infection traditionally associated with Sporothrixschenckii, a dimorphic organism that was first described more than a century ago in human andrat specimens [1].[.. Read More

Arch Microbiol 2019 Jan 9;201(1):135-141. Epub 2018 Oct 9.

División de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de Guanajuato, Apartado Postal 187, 36000, Guanajuato, Gto, Mexico.

Sporothrix schenckii is the etiological agent of sporotrichosis, a mycosis of humans and other mammals. Little is known about the responses of this thermodimorphic pathogen to perturbations in the cell wall (CW) by different stress conditions. Here we describe the effect of Congo Red (CR) on the fungal growth, morphogenesis and activity of glucosamine-6-phosphate (GlcN-6-P) synthase. Read More

Med Mycol 2018 Sep 28. Epub 2018 Sep 28.

Post-Graduation Program in Health Science, Federal University of Rio Grande (FURG), Rio Grande, Brazil.

Zoonotic sporotrichosis has undergone a geographical expansion in Brazil in the last decade. Rio Grande do Sul (RS) is the second state of the country in which a number of feline sporotrichosis cases have been described. Since cats are the main zoonotic source of infection, this study aimed to describe 100 cases of human sporotrichosis occurring in the last 5 years in the southern region of RS, Brazil. Read More

Plasmid 2018 11 17;100:1-5. Epub 2018 Sep 17.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P. 36050, Guanajuato, Mexico. Electronic address:

Some members of the Sporothrix genus can cause sporotrichosis, a worldwide distributed mycosis that affects several mammalian species, including human beings. Sporothrix schenckii and Sporothrix brasiliensis are the fungal species frequently associated with this disease, and the latter has gained significant interest because of the increased number of cases associated with transmission by cats. Despite the relevance of these organisms in the medical field, limited strategies for their genetic manipulation have been explored. Read More

Fungal Biol 2018 10 19;122(10):1023-1030. Epub 2018 Jul 19.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Col. Noria Alta, C.P. 36050, Guanajuato, Gto, Mexico. Electronic address:

Sporotrichosis is an infection caused by members of the Sporothrix genus, and among them, Sporothrix schenckii is one of the etiological agents. Both, the disease and the causative agent have gained interest in the recent years, because of the report of epidemic outbreaks, and the description of the disease transmission from animals to human beings. Despite the relevance of S. Read More