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Rev Bras Med Vet 2022 26;44:e004821. Epub 2022 May 26.

Veterinarian, DSc. DMCV, IV, UFRRJ. Seropédica, RJ, Brazil.

Feline sporotrichosis is a major clinical problem among cats in Brazil and is also a neglected, but important, public health issue, due to its zoonotic potential. The nasal clinical form of the disease is particularly challenging, having treatment refractoriness and clinical signs relapse as common features. This case series study aimed to preliminarily describe the effects of the azolic antifungal drug, clotrimazole, as a topical 1% solution spray, together with itraconazole on inducing disease remission, as well as treatment tolerability and safety. Read More

J Fungi (Basel) 2022 Jun 4;8(6). Epub 2022 Jun 4.

Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.

In Brazil, sporotrichosis has transitioned from a rural to urban disease, driven by a shift in the initiation of infection from the accidental inoculation of organic matter to the traumatic implantation of the fungus by cats. Since the emergence of zoonotic sporotrichosis caused by , investigations have largely ignored the environmental habitat of the pathogen due to its association with domestic cats. Therefore, we investigated 18 environmental samples collected from rural areas of two cities where zoonotic sporotrichosis is endemic, but where domestic cats are scarce. Read More

J Fungi (Basel) 2022 May 30;8(6). Epub 2022 May 30.

Efficiency, Quality, and Costs in Health Services Research Group (EFISALUD), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain.

Background: Sporotrichosis is a fungal infection caused by species of the genus. Presently, the prevalence of sporotrichosis in the Americas is unknown, so this study aims to analyze the cases reported in the past 10 years.

Methods: An advanced search was conducted from 2012 to 2022 in English and Spanish in PUBMED, SciELO, and Cochrane, with the terms: "sporotrichosis", "lymphocutaneous ", "fixed sporotrichosis", "mycosis", " spp. Read More

Arq Bras Oftalmol 2022 May-Jun;85(3):320-321

Laboratory of Infectious Ophthalmology, Instituto Nacional de Infectologia, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

PLoS Negl Trop Dis 2022 06 17;16(6):e0010484. Epub 2022 Jun 17.

Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.

Chronic topical cases of Sporotrichosis, a chronic fungal infection caused by the ubiquitously present cryptic members of the Sporothrix species complex, are treated with oral administrations of itraconazole. However, severe pulmonary or disseminated cases require repeated intra-venous doses of amphotericin B or even surgical debridement of the infected tissue. The unavoidable adverse side-effects of the current treatments, besides the growing drug resistance among Sporothrix genus, demands exploration of alternative therapeutic options. Read More

Cell Immunol 2022 Jun 3;378:104555. Epub 2022 Jun 3.

Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany. Electronic address:

Sporotrichosis is a deep mycosis caused by dimorphic species of the genus Sporothrix, with differences in pathogenicity between S. schenckii and S. brasiliensis species. Read More

Front Cell Infect Microbiol 2022 27;12:893501. Epub 2022 May 27.

Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

The zoonotic transmission of sporotrichosis due to occurs largely in Rio de Janeiro state, Brazil since the 1990´s. Most patients infected with respond well to itraconazole or terbinafine. However, a few patients have a slow response or do not respond to the treatment and develop a chronic infection. Read More

Photodiagnosis Photodyn Ther 2022 Jun 9:102952. Epub 2022 Jun 9.

The Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Jining 272000, Shandong, China; Department of Dermatology, Jining No.1 People's Hospital, Jining 272001, Shandong, China. Electronic address:

Cutaneous infectious granulomas are mainly caused by fungi and bacteria. Antibiotics are the primary therapeutic choices for the diseases, but the drug-resistant pathogens become increasingly prevalent. Thus, there is an urgent need to explore novel approaches to treating cutaneous infectious granulomas. Read More

Rev Soc Bras Med Trop 2022 6;55:e0021. Epub 2022 Jun 6.

Universidade Federal de Minas Gerais, Departamento de Medicina Veterinária Preventiva, Belo Horizonte, MG, Brasil.

Although sporotrichosis requires a broad approach for control, few reports have described the relationship between the index case and secondary contacts. In the present work, we report an outbreak involving a woman, a dog, and two cats from the same household environment, including the clinical and epidemiological aspects and outcomes, and discuss the importance of a One Health approach to face this neglected disease. The joint efforts of professionals such as veterinarians and physicians are essential for early diagnosis and surveillance, which contributes to the rapid identification and control of zoonotic sporotrichosis outbreaks. Read More

Front Cell Infect Microbiol 2022 12;12:894297. Epub 2022 May 12.

Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Sporotrichosis has been expanding throughout the Brazilian territory in recent years. New outbreaks have emerged, and consequently, the sporotrichosis agents, mainly , should remain in the environment somehow. Therefore, the aim of this study was to investigate the presence of spp. Read More

Vet Q 2022 Dec;42(1):95-118

School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia.

Fish and aquatic-derived zoonotic diseases have caused considerable problems in the aquaculture industry and fishery worldwide. In particular, zoonotic diseases can pose widespread threats to humans. With the world's growing population and potential global trade of aquaculture and fish, the risk of environmental contamination and development of fish and aquatic-derived zoonoses in humans are increasing. Read More

J Fungi (Basel) 2022 May 21;8(5). Epub 2022 May 21.

Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil.

Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. Read More

J Fungi (Basel) 2022 May 20;8(5). Epub 2022 May 20.

Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, A.C., Calle 43 No. 130, Col. Chuburná de Hidalgo, Mérida, Yucatan 97205, Mexico.

The fungal cell wall is an attractive structure to look for new antifungal drug targets and for understanding the host-fungus interaction. is one of the main causative agents of both human and animal sporotrichosis and currently is the species most studied of the genus. The cell wall of this organism has been previously analyzed, and rhamnoconjugates are signature molecules found on the surface of both mycelia and yeast-like cells. Read More

J Fungi (Basel) 2022 Apr 30;8(5). Epub 2022 Apr 30.

Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ), Fiocruz. Av. Brasil, 4365, Manguinhos, Rio de Janeiro 21040-900, Brazil.

Although rare, disseminated sporotrichosis is increasing in several countries. Despite its limiting toxic potential, amphotericin B is the only intravenous antifungal available to treat severe sporotrichosis. We aimed to describe the effectiveness and safety of amphotericin B treatment for severe sporotrichosis. Read More

J Fungi (Basel) 2022 Apr 28;8(5). Epub 2022 Apr 28.

Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK.

Fungal infections commonly present with myriad symptoms that mimic other clinical entities, notable amongst which is tuberculosis. Besides histoplasmosis and chronic pulmonary aspergillosis, which can mimic TB, this review has identified several other fungal infections which also do. A total of 80 individual cases misdiagnosed as TB are highlighted: aspergillosis ( = 18, 22. Read More

J Fungi (Basel) 2022 Apr 23;8(5). Epub 2022 Apr 23.

Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico.

Sporotrichosis is a subacute, or chronic mycosis caused by traumatic inoculation of material contaminated with the fungus which is part of the spp. complex. The infection is limited to the skin, although its progression to more severe systemic or disseminated forms remains possible. Read More

J Fungi (Basel) 2022 Apr 23;8(5). Epub 2022 Apr 23.

Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-90, RJ, Brazil.

Sporotrichosis is a subacute/chronic subcutaneous mycosis. Since the late 1990s, there has been a hyperendemic zoonotic transmission in the state of Rio de Janeiro, involving , the most virulent causative species, and a "belt" was described along the limits between the capital and its outskirts ("Baixada Fluminense"). This study analyzes the distribution of sporotrichosis using secondary data from the Notifiable Diseases Information System (Sinan) of the Rio de Janeiro State Health Department (SES/RJ) from 2011 to 2015 and from the INI Electronic Patient Record System (Sipec) from 2008 to 2015. Read More

ANZ J Surg 2022 May 26. Epub 2022 May 26.

Department of Surgery, Western District Health Service, Hamilton, Australia.

Expert Opin Drug Discov 2022 Jun 9:1-19. Epub 2022 Jun 9.

Department of Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Introduction: The three fungal skin neglected tropical diseases (NTD) - mycetoma, chromoblastomycosis and sporotrichosis - currently lack prioritization and support to establish drug discovery programs in search for novel treatment options. This has made the efforts to identify novel drugs for these fragmented skinNTDs.

Areas Covered: To help escalate the discovery of novel drugs to treat these fungal skinNTDs, the authors have prepared an overview of the compounds with activity against fungal skinNTDs by analyzing data from individual drug discovery studies, including those performed on the Medicines for Malaria Venture (MMV) open access boxes. Read More

BMJ Case Rep 2022 May 24;15(5). Epub 2022 May 24.

Pathology, Barts Health NHS Trust, London, UK

A veterinarian presented with multiple erythematous tender nodules over his right hand and arm. One month prior to the appearance of the lesions, he had treated a cat imported from Brazil who had ulcerated pustular cutaneous lesions. Despite antibiotic treatment there had been no improvement in his symptoms. Read More

Med Mycol Case Rep 2022 Jun 8;36:31-34. Epub 2022 May 8.

Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.

Sporotrichosis is a global occurring implantation (subcutaneous) mycosis, caused by species, usually affecting the skin and the lymphatic vessels, from where it can disseminate. Nowadays, the vast majority of sporotrichosis infections in Brazil are caused by zoonotic transmission of which is the main etiologic agent. We report a cutaneous disseminated case of this disease, observed in an immunocompetent farmer living in southern Brazil, the -infection was successfully treated with itraconazole. Read More

Arq Bras Oftalmol 2022 May 9. Epub 2022 May 9.

Ophthalmology Service, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

Ocular sporotrichosis involving adnexa can present in 4 types: granulomatous conjunctivitis, dacryocystitis, Parinaud oculoglandular syndrome, and bulbar conjunctivitis. The incidence of ocular sporotrichosis has increased in regions with high incidence rates of sporotrichosis. We present a series of three cases of ocular involvement by the fungus Sporothrix species, including its manifestations, approaches, and relevance in areas where sporotrichosis has considerable incidence rates. Read More

J Dermatol 2022 May 10. Epub 2022 May 10.

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Rev Chilena Infectol 2021 12;38(6):811-815

Servicio de control epidemiológico e infectología, Hospital Nacional de Pediatría, Ciudad Autónoma de Buenos Aires, Argentina.

Sporotrichosis is a subacute-chronic fungal infection caused by dimorphic fungi of the Sporothrix schenckii Complex. It is more common in tropical areas. The prevalence in Argentina is estimated between 0. Read More

Dermatol Online J 2022 Jan 15;28(1). Epub 2022 Jan 15.

Dermatologia, Hospital Universit�rio Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil..

Protothecosis is a rare condition caused by the aclorophylated algae of the genus Prototheca. We described an exuberant case treated as sporotrichosis with prolonged course which evolved to arm deformation. Itraconazole treatment for 8 months was inefective. Read More

Infect Drug Resist 2022 22;15:2067-2090. Epub 2022 Apr 22.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, 36050, Gto., México.

Sporotrichosis is an important subcutaneous mycosis with high prevalence and threat to human and animal health worldwide. , and are the main etiological agents of this disease; and even though many efforts have been made recently to understand the -host interaction, little is known about , an underestimated species. This organism shows the lowest virulence among the members of the pathogenic clade and represents an important pathogenic agent due to its global distribution. Read More

J Fungi (Basel) 2022 Apr 9;8(4). Epub 2022 Apr 9.

Centre d'Infectiologie Charles Mérieux, Université d'Antananarivo, Antananarivo 101, Madagascar.

Chromoblastomycosis and sporotrichosis are the two main implantation mycoses that are now recognized as fungal neglected tropical diseases (NTDs). Their laboratory diagnosis mainly relies on direct microscopy, histopathology, and identification of the fungus by culture. However, to be appropriately used, these techniques require mycological expertise that is not widely available and may be absent in peripheral health care facilities in endemic areas. Read More

Microb Pathog 2022 May 18;166:105539. Epub 2022 Apr 18.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, SP, Brazil. Electronic address:

Sporotrichosis is a cosmopolitan mycosis caused by pathogenic species of Sporothrix genus, that in Brazil is often acquired by zoonotic transmission involved infected cats with S. brasiliensis. Previous studies showed that the Sporothrix spp. Read More

Exp Dermatol 2022 Apr 20. Epub 2022 Apr 20.

Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.

Macrophages, which serve as a bridge between innate and adaptive immunity, play an important role in sporotrichosis. Sporothrix schenckii infections can produce immune responses such as macrophage polarization and inflammatory factor secretion. In the early stages of inflammation, the expression of DAB2 in macrophages is increased, which controls the secretion of inflammatory factors and affects the polarization of macrophages. Read More

Infect Drug Resist 2022 11;15:1753-1765. Epub 2022 Apr 11.

Department of Dermatology, the Second Hospital of Jilin University, Changchun, 130041, People's Republic of China.

Introduction: This study was aimed to examine the clinical and epidemiological characteristics of sporotrichosis in China and specifically Jilin Province, which is one of the areas with the highest incidence worldwide, and to provide data support for the global prevalence of sporotrichosis.

Methods: A total of 4969 cases of sporotrichosis diagnosed at the Second Hospital of Jilin University from January 1, 1990 to December 31, 2019 were collected.

Results: In Jilin Province, the male-to-female ratio was 1:2, the average age at onset was 48 ± 1 years, and the average disease duration was 4. Read More