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    1 OF 39

    Dectin-1 expression by macrophages and related antifungal mechanisms in a murine model of Sporothrix schenckii sensu stricto systemic infection.
    Microb Pathog 2017 Jun 20. Epub 2017 Jun 20.
    Department of Clinical Analysis, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University " Júlio de Mesquita Filho " - UNESP, Araraquara, SP, Brazil. Electronic address:
    The available information about the role of Dectin-1 in sporotrichosis is scarce. Hence, we aimed to assess Dectin-1 expression by macrophages and the activation of some related antifungal mechanisms during the Sporothrix schenckii sensu stricto infection as a first attempt to elucidate the role of this receptor in sporotrichosis. Balb/c mice were intraperitoneally infected with S. Read More

    Sporotrichosis masquerading as pyoderma gangrenosum.
    J Eur Acad Dermatol Venereol 2017 Jun 19. Epub 2017 Jun 19.
    Hospital Copa D'Or.
    Sporotrichosis is a subcutaneous mycosis with a worldwide distribution caused by species of the Sporothrix schenkii complex. Since 1998, it has reached epidemic proportions in the city of Rio de Janeiro, Brazil, via transmission from infected cats to humans. The species identified as the primary cause was Sporothrix brasiliensis. Read More

    Antifungal susceptibility of Sporothrix schenckii complex biofilms.
    Med Mycol 2017 Jun 8. Epub 2017 Jun 8.
    Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Department of Pathology and Legal Medicine, Federal University of Ceará, Ceará, Brazil.
    Sporotrichosis, caused by species of Sporothrix schenckii complex, is the most prevalent subcutaneous mycosis in many areas of Latin America. The aim of this study was to evaluate the ability of Sporothrix spp. to form biofilms in vitro and to characterize the growth kinetics, morphology, and antifungal susceptibility of biofilms against classical antifungals. Read More

    Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil.
    Rev Inst Med Trop Sao Paulo 2017 Jun 1;59:e33. Epub 2017 Jun 1.
    Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway.

    Aims: To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL).

    Methods: From January 2004 to December 2010, 23 cases of SL (4. Read More

    Efficacy of a poly-aggregated formulation of amphotericin B in treating systemic sporotrichosis caused by Sporothrix brasiliensis.
    Med Mycol 2017 Jun 1. Epub 2017 Jun 1.
    Laboratory of Cellular Mycology and Proteomics, Department of Cell Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
    In severe cases of sporotrichosis, it is recommended to use amphotericin B deoxycholate (D-AMB) or its lipid formulations and/or in association with itraconazole (ITC). Our aim was to evaluate the antifungal efficacy of a poly-aggregated amphotericin B (P-AMB), a nonlipid formulation, compared with D-AMB on systemic sporotrichosis caused by Sporothrix brasiliensis. In vitro assays showed that Sporothrix schenckii sensu stricto and S. Read More

    Practical Management of Deep Cutaneous Fungal Infections.
    Med Mycol J 2017 ;58(2):E71-E77
    Department of Dermatology, Kitasato University Kitasato Institute Hospital.
    Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining. Read More

    Sporothrix schenckii sensu stricto and Sporothrix brasiliensis Are Differentially Recognized by Human Peripheral Blood Mononuclear Cells.
    Front Microbiol 2017 10;8:843. Epub 2017 May 10.
    Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de GuanajuatoGuanajuato, Mexico.
    Sporothrix schenckii sensu stricto and S. brasiliensis are usually associated to sporotrichosis, a subcutaneous mycosis worldwide distributed. Comparative analyses between these two species indicate they contain genetic and physiological differences that are likely to impact the interaction with host cells. Read More

    Sporotrichal Tenosynovitis Diagnosed Helpfully by Musculoskeletal Ultrasonography.
    Intern Med 2017 15;56(10):1243-1246. Epub 2017 May 15.
    Department of Clinical Research, Osaka Minami Medical Center, Japan.
    A 72-year-old man presented with persistent oligoarthritis and positive results for rheumatoid factor and was suspected of having rheumatoid arthritis (RA). However, the musculoskeletal ultrasonography (MSUS) findings were not consistent with those of typical RA. He had undergone surgery for carpal tunnel syndrome, which allowed both histopathological and microbiological examinations to be performed. Read More

    Fungal infection control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosis.
    Braz J Biol 2017 May 4. Epub 2017 May 4.
    Department of Clinical Analysis, School of Pharmaceutical Sciences, Universidade Estadual Paulista "Júlio de Mesquita Filho" - UNESP, Rodovia Araraquara-Jaú, Km 1, CEP 14801-902, Araraquara, SP, Brazil.
    Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. Read More

    Sporotrichosis among children of a hyperendemic area in Peru: an 8-year retrospective study.
    Int J Dermatol 2017 May 9. Epub 2017 May 9.
    Medicine School, Universidad Nacional Mayor de San Marcos, Lima, Peru.
    Background: The clinical and epidemiologic characteristics of pediatric sporotrichosis are poorly understood.

    Objective: To describe the incidence and clinical characteristics of cases of sporotrichosis in children 14 years of age and younger reported in Abancay from 2004 to 2011, stratified according to age.

    Methods: We performed a retrospective review of pediatric patients 14 years of age and younger who were diagnosed with sporotrichosis in a referral center at Abancay, a poor area located in the south central highlands of Peru, to estimate the incidence rates (per 100,000 person-years) according to age and sporotrichosis type (lymphocutaneous and fixed), and clinical characteristics of these patients. Read More

    Polar Origanum vulgare (Lamiaceae) extracts with antifungal potential against Sporothrix brasiliensis.
    Med Mycol 2017 May 6. Epub 2017 May 6.
    Department of Preventive Veterinary, Federal University of Pelotas, Pelotas, RS, Brazil.
    Oregano (Origanum vulgare) has anti-Sporothrix spp. activity, including against strains that are resistant to antifungal drugs. As the studies are limited to the essential oil, the aim of this study was to evaluate the chemical, antioxidant and cytotoxic properties of polar oregano extracts and their anti-Sporothrix brasiliensis activity. Read More

    In vitro susceptibility of Sporothrix brasiliensis: Comparison of yeast and mycelial phases.
    Med Mycol 2017 May 4. Epub 2017 May 4.
    Post-Graduation Program in Health Science, Federal University of Rio Grande (FURG), Rio Grande, Brazil.
    Sporothrix brasiliensis has emerged as an important cause of sporotrichosis, particularly associated with feline and zoonotic cases. Owing to the paucity of data on antifungal activity against this species, the present study aimed to evaluate the in vitro susceptibility of clinical isolates of S. brasiliensis in the mycelial and yeast phases to itraconazole (ITZ), terbinafine (TRB), and amphotericin B (AMB). Read More

    Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis.
    Mem Inst Oswaldo Cruz 2017 May;112(5):376-381
    Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Micologia, Rio de Janeiro, RJ, Brasil.
    Background: Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. Read More

    Unique case report of a chromomycosis and Listeria in soft tissue and cerebellar abscesses after kidney transplantation.
    BMC Infect Dis 2017 Apr 20;17(1):288. Epub 2017 Apr 20.
    Département d'Urologie, Néphrologie et Transplantation, AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix. 47-83, Bd de l'Hôpital, 75013, Paris, France.
    Background: Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique association of abscesses caused by a chromomycosis and Listeria monocytogenes in a kidney transplant recipient, and didactically expose how the appropriate diagnosis was reached. Read More

    Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis: is it a good antigen for serological diagnosis of paracoccidioidomycosis?
    Braz J Med Biol Res 2017 Apr 3;50(4):e5928. Epub 2017 Apr 3.
    Departamento de Biologia, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
    Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. Read More

    Origin and distribution of Sporothrix globosa causing sapronoses in Asia.
    J Med Microbiol 2017 May 22;66(5):560-569. Epub 2017 May 22.
    4​Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands 2​Biological Sciences Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
    Purpose: The aim of the study was to evaluate the main sources and epidemiological patterns and speculate on the evolutionary origin of Sporothrix globosa in Asia.

    Methodology: Case and case series literature on sporotrichosis in Asia from January 2007 onwards were reviewed using meta-analysis. Phylogenetic analysis of relevant S. Read More

    The Efficacy of Humanized Antibody against the Sporothrix Antigen, gp70, in Promoting Phagocytosis and Reducing Disease Burden.
    Front Microbiol 2017 3;8:345. Epub 2017 Mar 3.
    Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo São Paulo, Brazil.
    Sporotrichosis is a subcutaneous mycosis distributed worldwide and is frequently reported in countries with tropical climates, as Latin America countries. We previously demonstrated that mice with sporotrichosis produce specific antibodies against a 70-kDa fungal protein, indicating that specific antibodies against this molecule may help to control the sporotrichosis. IgG1 monoclonal antibody was generated, and called mAbP6E7, in mice against a 70-kDa glycoprotein (gp70) of S. Read More

    Oxidative stress in rats experimentally infected by Sporothrix schenckii.
    Microb Pathog 2017 Jun 7;107:1-5. Epub 2017 Mar 7.
    Department of Small Animals, Universidade Federal de Santa Maria, Brazil. Electronic address:
    The aim of this study was to evaluate whether oxidative stress occurs in rats experimentally infected by Sporothrix schenckii, and its possible effect on disease pathogenesis. Thirty rats were divided into two groups: the group A (uninfected, n = 18) and the group B (infected by S. schenckii, n=21). Read More

    Chemical and cytotoxic analyses of brown Brazilian propolis (Apis mellifera) and its in vitro activity against itraconazole-resistant Sporothrix brasiliensis.
    Microb Pathog 2017 Apr 17;105:117-121. Epub 2017 Feb 17.
    Centro de Diagnóstico e Pesquisa em Micologia Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
    This study aimed to evaluate the chemical composition and cytotoxic activity of brown Brazilian propolis and its in vitro activity against itraconazole-resistant Sporothrix brasiliensis from animal sporotrichosis. Propolis was acquired commercially and prepared as a hydroalcoholic extract. Chemical analysis was evaluated by liquid chromatography coupled to mass spectrometry of ultra-efficiency. Read More

    The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.
    Immunology 2017 Jun 3;151(2):154-166. Epub 2017 Mar 3.
    Department of Clinical Analysis, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University (FCF/UNESP), Araraquara, Brazil.
    Sporotrichosis is a mycosis caused by fungi from the Sporothrix schenckii species complex, whose prototypical member is Sporothrix schenckii sensu stricto. Pattern recognition receptors (PRRs) recognize and respond to pathogen-associated molecular patterns (PAMPs) and shape the following adaptive immune response. A family of PRRs most frequently associated with fungal recognition is the nucleotide-binding oligomerization domain-like receptor (NLR). Read More

    Comparison of two in vitro antifungal sensitivity tests and monitoring during therapy of Sporothrix schenckii sensu stricto in Malaysian cats.
    Vet Dermatol 2017 Feb;28(1):156-e32
    Servizi Dermatologici Veterinari, Strada Bedale della Ressia 2, 12016, Peveragno (CN), Italy.
    Background: Feline sporotrichosis is common in Malaysia. Thermosensitivity and effects of azole treatment on fungal susceptibility are unknown.

    Objectives: To evaluate thermotolerance and antifungal susceptibility of feline Malaysian Sporothrix isolates, compare microdilution (MD) and E-test results, and investigate changes in susceptibility during azole therapy. Read More

    Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission.
    PLoS Pathog 2017 Jan 19;13(1):e1006077. Epub 2017 Jan 19.
    Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil.

    The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host.
    Neurohospitalist 2017 Jan 5;7(1):30-34. Epub 2016 Apr 5.
    Department of Neurology, University of California, San Francisco, CA, USA; Infectious Diseases, Department of Medicine, University of California, San Francisco, CA, USA.
    Chronic meningitis of unknown etiology is a vexing illness for patients and clinicians. Identification of the correct pathogen can be challenging and time consuming, leading to delays in appropriate treatment. Although Sporothrix schenckii is a recognized and treatable cause of chronic meningitis, neurologists and infectious diseases physicians may not regularly evaluate for Sporothrix infection. Read More

    Sporothrix schenckii Sensu Lato identification in fragments of skin lesion cultured in NNN medium for differential diagnosis of cutaneous leishmaniasis.
    Diagn Microbiol Infect Dis 2017 Feb 15;87(2):118-120. Epub 2016 Nov 15.
    Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Fellow researcher of Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil; Fellow researcher ("Cientista do Nosso Estado") of Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Brazil.
    Eighty-nine patients with clinical suspicion of leishmaniasis were referred for differential diagnosis. Sporothrix schenckii sensu lato was isolated in Novy-MacNeal-Nicolle + Schneider media in 98% of 64 patients with final diagnosis of sporotrichosis. This medium may be suitable for diagnosis of sporotrichosis in areas where cutaneous leishmaniasis is also endemic. Read More

    [Presence of lactoferrin (LF) in lymphocutaneous sporotrichosis. Yeast-bound antimicrobial peptide].
    Gac Med Mex 2016 Nov - Dec;152(6):831-835
    Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, Ciudad de México, México.
    Sporotrichosis is a common subcutaneous mycosis in Latin America, produced by dimorphic fungi belong to Sporothrix schenckii complex of cryptic species. Infection is acquired by traumatic inoculation with contaminated organic material. Host immune response includes polymorphonuclear neutrophils chemotaxis and release of granular components. Read More

    Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii.
    J Ethnopharmacol 2017 Jan 14;195:266-274. Epub 2016 Nov 14.
    Faculdade de Ciências Farmacêuticas. Universidade Estadual Paulista Julio Mesquita Filho, UNESP, Rod. Araraquara-Jaú - Km 1 -s/n -CEP: 14800-903, Araraquara, SP, Brazil.
    Ethnopharmacological Relevance: Vismia guianensis (Aubl.) Pers. is traditionally used in North and Northeast of Brazil for the treatment of dermatomycoses. Read More

    Efficacy and safety of itraconazole use in infants.
    World J Pediatr 2016 Nov 10;12(4):399-407. Epub 2016 Jun 10.
    Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China.
    Background: Itraconazole has been used to treat fungal infections, in particular invasive fungal infections in infants or neonates in many countries.

    Data Sources: Literature search was conducted through Ovid EMBASE, PubMed, ISI Web of Science, CNKI and Google scholarship using the following key words: "pediatric" or "infant" or "neonate" and "fungal infection" in combination with "itraconazole". Based on the literature and our clinical experience, we outline the administration of itraconazole in infants in order to develop evidence-based pharmacotherapy. Read More

    Refractory sporotrichosis due to Sporothrix brasiliensis in humans appears to be unrelated to in vivo resistance.
    Med Mycol 2016 Oct 22. Epub 2016 Oct 22.
    Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
    Sporotrichosis is a subacute to chronic infection caused by members of the Sporothrix schenckii complex. Itraconazole is the first choice antifungal drug for treating this infection, with terbinafine and potassium iodide as alternatives and amphotericin B used in cases of severe infections. Correlation of antifungal susceptibility data with the clinical outcome of the patients is scarce. Read More

    Invasive Fungal Disease in Renal Transplant Recipients at a Brazilian Center: Local Epidemiology Matters.
    Transplant Proc 2016 Sep;48(7):2306-2309
    Infectious Disease Clinic, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
    Introduction: Invasive fungal disease (IFD) is an important complication after solid organ transplantation (SOT). A marked geographic variation in the epidemiology of IFD after kidney transplantation (KT) has been suggested by the results of previous studies. Nevertheless, data from Latin American centers are scarce. Read More

    Tinea on a Tattoo.
    Acta Dermatovenerol Croat 2016 Aug;24(3):223-4
    Marius Irimie, MD, 40, Zizinului Street, Bl. 31, Sc. C, Ap. 2, 500414, Brasov, Romania;
    In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19). Read More

    Antifungal and immunomodulatory activity of a novel cochleate for amphotericin B delivery against Sporothrix schenckii.
    Int Immunopharmacol 2016 Nov 16;40:277-287. Epub 2016 Sep 16.
    Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, Universidade Estadual Paulista Julio Mesquita Filho, UNESP, Rodovia Araraquara-Jaú - Km 1, CEP: 14801-902, Araraquara, São Paulo, Brazil. Electronic address:
    Introduction: Sporotrichosis is an emergent subcutaneous mycoses caused by species of the Sporothrix schenckii complex. Amphotericin B (AmB) remains the main antifungal drug for the treatment of systemic infections, but its use is limited by toxicity reasons. AFCo3 is a novel cochleate containing detoxified LPS, which exhibits drug delivery and immunomodulating properties. Read More

    Whole-Genome Sequencing and In Silico Analysis of Two Strains of Sporothrix globosa.
    Genome Biol Evol 2016 Dec 14;8(11):3292-3296. Epub 2016 Dec 14.
    IRCCS Centro Neurolesi "Bonino-Pulejo", SS113, Messina, Italy
    Sporothrix globosa is a thermo-dimorphic fungus belonging to a pathogenic clade that also includes Sporothrix schenckii, which causes human and animal sporotrichosis. Here, we present the first genome assemblies of two S. globosa strains providing data for future comparative genomic studies in pathogenic Sporothrix species. Read More

    Is There Any Difference between the In Situ and Systemic IL-10 and IFN-γ Production when Clinical Forms of Cutaneous Sporotrichosis Are Compared?
    PLoS One 2016 13;11(9):e0162764. Epub 2016 Sep 13.
    Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, RJ, Brazil.
    Fungus of the Sporothrix schenckii complex can produce skin lesions in humans, commonly lymphocutaneous (LC) and fixed (F) forms of sporotrichosis. Some authors have suggested that clinical forms are influenced by differences in virulence and genetic profile of isolates. But little is known about the role of immune response in determining the clinical outcome of sporotrichosis. Read More

    The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship.
    Stud Mycol 2016 27;83:165-91. Epub 2016 Jul 27.
    Department of Microbiology and Plant Pathology, Forestry and Agricultural Research Institute (FABI), University of Pretoria, Pretoria 0002, South Africa.
    One of the causal agents of human sporotrichosis, Sporothrix schenckii, is the type species of the genus Sporothrix. During the course of the last century the asexual morphs of many Ophiostoma spp. have also been treated in Sporothrix. Read More

    Mortality From Fungal Diseases in the US Air Force From 1970 to 2013.
    US Army Med Dep J 2016 Oct-Dec(3-16):38-41
    New York State Department of Health, Albany, New York.
    We review a unique set of documents, death certificates, catalogued in the US Air Force Mortality Registry, which tracks deaths for current and retired Air Force service members. We screened the records for all deaths caused by fungal diseases between 1970 and 2013. There were 216 deaths caused by a variety of diseases such as aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, pneumocystosis, sporotrichosis, and zygomycosis. Read More

    Osteomyelitis caused by Sporothrix schenckii in an immunocompetent patient.
    Rev Soc Bras Med Trop 2016 Jul-Aug;49(4):527-9
    Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
    Sporotrichosis is the most common subcutaneous mycosis in South America and its association with zoonotic transmission remains a relevant public health problem in Rio de Janeiro, Brazil. The disease most commonly presents as subacute or chronic cutaneous lesions, although dissemination to various organs and systems occurs in rare cases, mainly in immunosuppressed individuals. This report describes a case of sporotrichosis with severe bone and subcutaneous damage in an immunocompetent patient who did not exhibit the characteristic skin lesions of sporotrichosis, including ulcers, nodules, and lymphangitis. Read More

    [Epidemiological clinical and laboratory characterization of sporotrichosis in patients of a tertiary care hospital in Lima, Peru, from 1991 to 2014].
    Rev Chilena Infectol 2016 Jun;33(3):315-21
    Hospital Cayetano Heredia, Perú
    Background: Sporothricosis is endemic in numerous Latin American countries and the rest of the world. In Peru is concentrated in regions with warm and humid climate being little known in the rest of the country.

    Aim: To describe the epidemiological, clinical and laboratory characteristics of patients diagnosed of sporotrichosis in a tertiary-care level hospital in Lima, Peru from 1991 to 2014. Read More

    Disseminated sporotrichosis in an immunocompetent patient.
    Case Reports Plast Surg Hand Surg 2016 31;3(1):44-7. Epub 2016 May 31.
    Division of Infectious Diseases, Department of Medicine , Tucson , AZ , USA.
    Sporothrix schenckii, the causative agent of sporotrichosis, is a relatively rare infection. Local infection usually occurs through direct inoculation of the organism through the skin; disseminated disease is rarely seen. This article describes a case of disseminated sporotrichosis in a middle-aged man without the commonly seen risk factors for dissemination. Read More

    Studies in Phylogeny, Development of Rapid IdentificationMethods, Antifungal Susceptibility, and Growth Rates of Clinical Strains of Sporothrix schenckii Complex in Japan.
    Med Mycol J 2016 ;57(3):E47-57
    Medical Mycology Research Center, Chiba University.
    Sporotrichosis is a fungal infection caused by the Sporothrix species, which have distinct virulence profiles and geographic distributions. We performed a phylogenetic study in strains morphologically identified as Sporothrix schenckii from clinical specimens in Japan, which were preserved at the Medical Mycology Research Center, Chiba University. In addition, we examined the in vitro antifungal susceptibility and growth rate to evaluate their physiological features. Read More

    Adamantylidene-substituted alkylphosphocholine TCAN26 is more active against Sporothrix schenckii than miltefosine.
    Mem Inst Oswaldo Cruz 2016 Aug 11;111(8):523-7. Epub 2016 Jul 11.
    Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Instituto de Biofísica Carlos Chagas Filho, Laboratório de Biologia Celular de Fungos, Rio de Janeiro, RJ, Brasil.
    Sporotrichosis is the most frequent subcutaneous mycosis in the world and its increasing incidence has led to the search for new therapeutic options for its treatment. In this study, we demonstrated that three structural analogues of miltefosine (TCAN26, TC19, and TC70) showed inhibitory activity against Sporothrix schenckii sensu stricto and that TCAN26 was more active in vitro than miltefosine against several isolates. Scanning electron microscopy showed that S. Read More

    Disseminated cutaneous sporotrichosis associated with ocular lesion in an immunocompetent patient.
    An Bras Dermatol 2016 Jul-Aug;91(4):537-9
    Universidade Federal do Espírito Santo (UFES) - Vitória (ES), Brazil.
    A 59-year-old female patient, previously healthy, immunocompetent, presented left bulbar conjunctiva lesions and nodular-ulcerated lesions on the arms and cervical region, besides left cervical and retroauricular lymphadenopathy. She had previous contact with domestic cats that excoriated her face. The diagnosis was conclusive of disseminated sporotrichosis through clinical and epidemiological history and cultures of skin and ocular secretions. Read More

    [Virulence of Sporothrix globosa in murine models].
    Rev Argent Microbiol 2016 Jul - Sep;48(3):196-199. Epub 2016 Aug 25.
    Anatomía Patológica, Universidad de Valparaíso, Chile.
    Introduction: The sporothricosis disease is an infection caused by species included in Sporothrix schenkii complex.

    Objective: Verify the virulence of a strain of S. globosa using two different concentrations of inoculum by intraperitoneally and subcutaneously, into a mouse model. Read More

    In Vitro Susceptibility of Sporothrix brasiliensis to Essential Oils of Lamiaceae Family.
    Mycopathologia 2016 Dec 16;181(11-12):857-863. Epub 2016 Aug 16.
    Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
    This study evaluated the chemical, cytotoxic and anti-Sporothrix brasiliensis properties of commercial essential oils of rosemary (Rosmarinus officinalis L.), oregano (Origanum vulgare L.) and marjoram (Origanum majorana L. Read More

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