2,034 results match your criteria Sporotrichosis


Atypical Manifestation of Disseminated Sporotrichosis in an AIDS Patient.

Case Rep Dermatol 2018 Sep-Dec;10(3):231-237. Epub 2018 Oct 24.

Sector of Dermatology and Post-Graduation Course, HUCFF-UFRJ and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Sporotrichosis is an infection caused by fungi of the complex. The clinical lymphocutaneous presentation corresponds to the great majority of cases. With the increased incidence of sporotrichosis in the State of Rio de Janeiro, Brazil, atypical clinical forms have been reported with increasing frequency, usually associated with immunosuppression. Read More

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October 2018
2 Reads

Epidemiology of Subcutaneous Mycoses in Northeast India: A Retrospective Study.

Indian J Dermatol 2018 Nov-Dec;63(6):496-501

Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Subcutaneous mycoses, although rare, are frequently reported from northeast India. Their spectrum varies with geographic region.

Materials And Methods: We evaluated clinical records and histopathological features of subcutaneous mycoses cases seen during April 2013 to March 2017. Read More

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December 2018

Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis.

PLoS One 2018 30;13(11):e0207644. Epub 2018 Nov 30.

Clinical Laboratory and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Feline sporotrichosis due to Sporothrix brasiliensis is frequently severe and often correlated to zoonotic transmission. Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) cause immunodeficiency in cats; no association has been identified with critical cases of sporotrichosis. Moreover, the cytokine profile in Sporothrix-infected cats and a potential impact of retrovirus co-infections on their immunity is unknown. Read More

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November 2018
1 Read

Report of 73 cases of cutaneous sporotrichosis in Mexico.

An Bras Dermatol 2018 Nov/Dec;93(6):907-909

Service of Dermatology and Department of Mycology, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, Mexico.

We report 73 cases of cutaneous sporotrichosis from the Community Dermatology program, at the central and mountain areas of the state of Guerrero, Mexico. A similar number of cases was found between children and adults, mostly peasants and school-age children with rural occupations. Upper limbs were the mostly affected and the predominant clinical form was lymphocutaneous (56. Read More

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October 2017

Palate ulcer, uvular destruction and nasal septal perforation caused by in an HIV-infected patient.

Med Mycol Case Rep 2019 Mar 12;23:16-19. Epub 2018 Nov 12.

Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, 20270-004 Rio de Janeiro, Brazil.

Sporotrichosis is a human and animal disease caused by dimorphic pathogenic species of the genus . We report a dramatic presentation of infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Read More

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March 2019
1 Read

The impact of the absence of Toll-like receptor-2 during Sporothrix brasiliensis infection.

J Med Microbiol 2018 Nov 19. Epub 2018 Nov 19.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brazil, Avenida Professor Lineu Prestes, 580, São Paulo, 05508-000, Brazil.

Purpose: Sporothrix brasiliensis, a member of the Sporothrix schenckii complex, is a major cause of epidemic outbreaks of sporotrichosis due to its greater virulence and ability to evade the immune system. The absence of studies about this species led to this study, with the aim to evaluate the importance of Toll-like receptor-2 (TLR-2) during S. brasiliensis infection. Read More

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November 2018
2 Reads

Sporothrix brasiliensis induces a more severe disease associated with sustained Th17 and regulatory T cells responses than Sporothrix schenckii sensu stricto in mice.

Fungal Biol 2018 Dec 24;122(12):1163-1170. Epub 2018 Aug 24.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, SP, Brazil. Electronic address:

Little is known about the differences in the CD4+ T-cell response induced by Sporothrix schenckii and Sporothrix brasiliensis, the most virulent species that cause sporotrichosis. Here, the helper (Th) and regulatory T cells (Tregs) responses were evaluated comparatively in a murine model of sporotrichosis on days 7, 21 and 35 after subcutaneous infection with either S. schenckii or S. Read More

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December 2018
1 Read

Sporotrichoid Keratoacanthomas: Case Report and Review of Neoplasms Presenting in a Sporotrichoid Pattern.

Cureus 2018 Aug 23;10(8):e3196. Epub 2018 Aug 23.

Dermatologist, San Diego Family Dermatology, San Diego, USA.

Sporotrichosis is a fungal infection known for its distinct pattern of infectious skin nodules. Several conditions can present with lesions that appear in a sporotrichoid pattern. An 82-year-old man that presented with three cutaneous nodules on his right leg in a sporotrichoid manner is described; biopsy of each lesion revealed a keratoacanthoma. Read More

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August 2018
5 Reads

Closing the Brief Case: Cutaneous Sporotrichosis in an Immunocompetent Patient after Travel to Peru.

J Clin Microbiol 2018 Nov 25;56(11). Epub 2018 Oct 25.

Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany

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November 2018

The Brief Case: Cutaneous Sporotrichosis in an Immunocompetent Patient after Travel to Peru.

J Clin Microbiol 2018 Nov 25;56(11). Epub 2018 Oct 25.

Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany

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November 2018

Extracellular Vesicles From Are an Important Virulence Factor That Induce an Increase in Fungal Burden in Experimental Sporotrichosis.

Front Microbiol 2018 2;9:2286. Epub 2018 Oct 2.

Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, Brazil.

Sporotrichosis is a mycosis that affects the skin, lymphatic system and other organs in humans and animals. The disease has a worldwide distribution, with endemic areas in Brazil, and is caused by a complex of species, including . Some fungi release extracellular vesicles (EVs) that can interact with the host cell and modulate the host immune response. Read More

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October 2018
1 Read
3.940 Impact Factor

Special Issue " and Sporotrichosis".

J Fungi (Basel) 2018 Oct 12;4(4). Epub 2018 Oct 12.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P.; Guanajuato Gto. 36050, México.

Sporotrichosis is a neglected, deep-seated fungal infection traditionally associated with Sporothrixschenckii, a dimorphic organism that was first described more than a century ago in human andrat specimens [1].[.. Read More

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October 2018
3 Reads

Congo Red affects the growth, morphology and activity of glucosamine-6-phosphate synthase in the human pathogenic fungus Sporothrix schenckii.

Arch Microbiol 2018 Oct 9. Epub 2018 Oct 9.

División de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de Guanajuato, Apartado Postal 187, 36000, Guanajuato, Gto, Mexico.

Sporothrix schenckii is the etiological agent of sporotrichosis, a mycosis of humans and other mammals. Little is known about the responses of this thermodimorphic pathogen to perturbations in the cell wall (CW) by different stress conditions. Here we describe the effect of Congo Red (CR) on the fungal growth, morphogenesis and activity of glucosamine-6-phosphate (GlcN-6-P) synthase. Read More

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October 2018
10 Reads

Human sporotrichosis: A zoonotic outbreak in southern Brazil, 2012-2017.

Med Mycol 2018 Sep 28. Epub 2018 Sep 28.

Post-Graduation Program in Health Science, Federal University of Rio Grande (FURG), Rio Grande, Brazil.

Zoonotic sporotrichosis has undergone a geographical expansion in Brazil in the last decade. Rio Grande do Sul (RS) is the second state of the country in which a number of feline sporotrichosis cases have been described. Since cats are the main zoonotic source of infection, this study aimed to describe 100 cases of human sporotrichosis occurring in the last 5 years in the southern region of RS, Brazil. Read More

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September 2018
2 Reads

Generation of a synthetic binary plasmid that confers resistance to nourseothricin for genetic engineering of Sporothrix schenckii.

Plasmid 2018 Nov 17;100:1-5. Epub 2018 Sep 17.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P. 36050, Guanajuato, Mexico. Electronic address:

Some members of the Sporothrix genus can cause sporotrichosis, a worldwide distributed mycosis that affects several mammalian species, including human beings. Sporothrix schenckii and Sporothrix brasiliensis are the fungal species frequently associated with this disease, and the latter has gained significant interest because of the increased number of cases associated with transmission by cats. Despite the relevance of these organisms in the medical field, limited strategies for their genetic manipulation have been explored. Read More

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November 2018
1 Read

Generation of Sporothrix schenckii mutants expressing the green fluorescent protein suitable for the study of host-fungus interactions.

Fungal Biol 2018 Oct 19;122(10):1023-1030. Epub 2018 Jul 19.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Col. Noria Alta, C.P. 36050, Guanajuato, Gto, Mexico. Electronic address:

Sporotrichosis is an infection caused by members of the Sporothrix genus, and among them, Sporothrix schenckii is one of the etiological agents. Both, the disease and the causative agent have gained interest in the recent years, because of the report of epidemic outbreaks, and the description of the disease transmission from animals to human beings. Despite the relevance of S. Read More

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October 2018
2 Reads

Cell Wall Proteins-Stimulated BMDCs Are Able to Induce a Th1-Prone Cytokine Profile In Vitro.

J Fungi (Basel) 2018 Sep 2;4(3). Epub 2018 Sep 2.

Department of Clinical Analysis, School of Pharmaceutical Sciences, Araraquara, São Paulo State University (UNESP), Rodovia Araraquara-Jaú-Km 1, Araraquara 14800-903, SP, Brazil.

Sporotrichosis is a subcutaneous mycosis affecting humans and other animals. The disease can be acquired by accidental inoculation of the fungus through the skin or through the respiratory system. Sporotrichosis can also be transmitted through bites or scratches by infected cats and more rarely by other animals (zoonotic transmission). Read More

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September 2018
3 Reads

Zoonotic Sporotrichosis Related to Cat Contact: First Case Report from Panama in Central America.

Cureus 2018 Jul 1;10(7):e2906. Epub 2018 Jul 1.

School of Medicine, Latina University of Panama, Panamá, PAN.

A previously healthy 34-year-old man presented with a four-week-old upper arm injury that started with a cat scratch and progressed into painless erythematous nodular ascending lesions in the left upper limb. We made the diagnosis of sporotrichosis based on the epidemiological association of the contact with a cat and culture identification. Sporotrichosis is a mycosis implantation caused by the Sporothrix schenckii complex. Read More

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July 2018
6 Reads

Cutaneous atypical mycobacteriosis with sporotrichoid clinical presentation caused by automotive accident.

An Bras Dermatol 2018 Sep-Oct;93(5):743-745

Infectious Diseases Clinic, Hospital da Santa Casa de São Paulo, São Paulo (SP), Brazil.

Atypical mycobacterial infections are caused by mycobacteria other than those from the M. tuberculosis complex and M. leprae. Read More

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October 2018
9 Reads

Immunity and Treatment of Sporotrichosis.

J Fungi (Basel) 2018 Aug 20;4(3). Epub 2018 Aug 20.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P., Guanajuato Gto. 36050, Mexico.

Species of the complex are the etiological agents of sporotrichosis, an important subcutaneous mycosis with several clinical forms and an increasing incidence around the world that affects humans and other mammals. The immunological mechanisms involved in the prevention and control of this mycosis are not entirely understood. Many reports have suggested that cell-mediated immunity has an essential role in the development of the disease, being the primary response controlling it, while only recent data supports that the humoral response is essential for the appropriate control. Read More

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August 2018
11 Reads

Skin Infections.

Prim Care 2018 Sep;45(3):433-454

Department of Family Medicine, Tidelands Health MUSC Family Medicine Residency Program, 4320 Holmestown Road, Myrtle Beach, SC 29588, USA.

The primary care provider will commonly see skin and soft tissue infections in the outpatient setting. Skin and soft tissue infections range from the uncomplicated impetigo to the potentially lethal necrotizing fasciitis. This article reviews these infections based on their underlying etiology: bacterial, fungal, and viral causes. Read More

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September 2018
22 Reads

Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents.

Future Microbiol 2018 08 16;13:1129-1140. Epub 2018 Aug 16.

Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Department of Pathology & Legal Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo, 1315 - Rodolfo Teófilo - CEP: 60430-275, Fortaleza, Ceará, Brazil.

Aim: The purpose of this study was to evaluate the effects of the antileishmanials meglumine antimoniate and pentamidine against Sporothrix schenckii complex.

Materials & Methods: The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifungal drugs (amphotericin B, itraconazole and terbinafine) was evaluated by the checkerboard assay. Read More

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August 2018
10 Reads

Ecological Determinants of Sporotrichosis Etiological Agents.

J Fungi (Basel) 2018 Aug 12;4(3). Epub 2018 Aug 12.

Dermatology Service & Mycology Department, Hospital General de México, "Dr. Eduardo Liceaga", Balmis 148, Colonia Doctores, Ciudad de México 06726, Mexico.

Ecological determinants of sporotrichosis etiological agents remain poorly understood. For this reason, we performed explorations using local climate estimates to determine the temperature and humidity ranges of the environment where clinically relevant species occur and to identify what plant species are associated with them, using data collected from the published literature. We performed a literature search to identify all publications on environmental isolations of medically relevant species of in the PubMed, SCOPUS, and EMBASE databases. Read More

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Monitoring Fungal Burden and Viability of spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response.

J Fungi (Basel) 2018 Aug 7;4(3). Epub 2018 Aug 7.

Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-360, Brazil.

Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone ( = 74) or combined with KI ( = 56). Read More

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August 2018
1 Read

Canine and feline cutaneous screw-worm myiasis in Malaysia: clinical aspects in 76 cases.

Vet Dermatol 2018 Oct 31;29(5):442-e148. Epub 2018 Jul 31.

Caring Veterinary Centre, 50 JLN Anggerik Vanilla Z31:Z, Kota Kemuning, 40460, Shah Alam, Malaysia.

Background: Cutaneous screw-worm myiasis in companion animals either due to the New World screw-worm, Cochliomyia hominivorax or the Old World screw-worm, Chrysomya bezziana, has been reported particularly in tropical and subtropical regions of the world. Although treatment of screw-worm myiasis in dogs has been described, few studies have been conducted regarding its clinical and epidemiological aspects in companion animals.

Objectives: To describe clinical and epidemiological aspects of canine and feline screw-worm myiasis. Read More

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October 2018
6 Reads

Immunopathogenesis of Human Sporotrichosis: What We Already Know.

J Fungi (Basel) 2018 Jul 31;4(3). Epub 2018 Jul 31.

Laboratory of Leishmaniasis Research, Oswaldo Cruz Institute, IOC/Fiocruz, Avenida Brasil 4365 Pavilhão 26 sala 509-Manguinhos, Rio de Janeiro 21040-360, Brazil.

Sporotrichosis is a subacute/chronic mycosis caused by dimorphic fungus of the genus This mycosis may affect both human and domestic animals and in the last few years, the geographic dispersion and increase of sporotrichosis worldwide has been observed. The occurrence of cases related to scratching/bites of domestic felines have increased, characterizing the disease as predominantly a zoonosis. In humans, sporotrichosis mainly involves the cutaneous tegument of infected patients, but other tissues may also present the infection. Read More

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July 2018
10 Reads

A case of disseminated sporotrichosis caused by .

Med Mycol Case Rep 2018 Sep 21;21:34-36. Epub 2018 Mar 21.

Westerdijk Fungal Biodiversity Institute, The Netherlands.

This paper presents a case of disseminated sporotrichosis in a 13-year-old female, originating from a rural area in Minas Gerais state, Brazil. The patient was hospitalized in Santa Casa hospital of Belo Horizonte, with hyporexia, prostration, fever and disseminated ulcerative lesions, besides anemia, leucopenia and sepsis of probable cutaneous focus. The patient was admitted without proven immunosuppression. Read More

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September 2018
2 Reads

Molecular Identification, Antifungal Susceptibility, and Geographic Origin of Clinical Strains of Complex in Mexico.

J Fungi (Basel) 2018 Jul 20;4(3). Epub 2018 Jul 20.

Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey 64460, Mexico.

Sporotrichosis is a subcutaneous mycosis caused by complex. The disease has been reported worldwide. However, the incidence of the etiological agent varies in its geographic distribution. Read More

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July 2018
1 Read

Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii.

Immunology 2018 Dec 14;155(4):467-476. Epub 2018 Aug 14.

Department of Clinical Analysis, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University (FCF/UNESP), Araraquara, Brazil.

Natural killer (NK) cells are one of the first cell types to enter inflammation sites and have been historically known as key effector cells against tumours and viruses; now, accumulating evidence shows that NK cells are also capable of direct in vitro activity and play a protective role against clinically important fungi in vivo. However, our understanding of NK cell development, maturation and activation in the setting of fungal infections is preliminary at best. Sporotrichosis is an emerging worldwide-distributed subcutaneous mycosis endemic in many countries, affecting humans and other animals and caused by various related thermodimorphic Sporothrix species, whose prototypical member is Sporothrix schenckii. Read More

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December 2018
3 Reads

Current trends to control fungal pathogens: exploiting our knowledge in the host-pathogen interaction.

Infect Drug Resist 2018 3;11:903-913. Epub 2018 Jul 3.

Department of Biology, Division of Exact and Natural Sciences, Campus Guanajuato, Universidad de Guanajuato,

Human fungal infections remain a major challenge in medicine. Only a limited number of antifungal drugs are available, which are often related to severe adverse effects. In addition, there is an increased emergence related to resistant strains, which makes imperative to understand the host-pathogen interactions as well as to develop alternative treatments. Read More

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July 2018
11 Reads

Sporotrichosis in Southern Brazil, towards an epidemic?

Zoonoses Public Health 2018 11 15;65(7):815-821. Epub 2018 Jul 15.

Mycology Lab, Faculty of Medicine, Federal University of Rio Grande (FaMed-FURG), Rio Grande, Brazil.

Rio Grande do Sul (RS) is the second highest state with respect to sporotrichosis incidence in Brazil, with most cases occurring in the southern region. Given the importance of epidemiologic monitoring in hyperendemic areas, this study evaluated the spatial, geographical and annual sporotrichosis incidence over a period of 7 years in the southern region of RS, as well as the disease evolution over the last two decades. Data were collected from the Mycology Laboratory of the Federal University of Rio Grande (FAMED-FURG) and from the Centre for Zoonosis Control (CZC) of the Prefeitura Municipal of Pelotas city. Read More

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November 2018
3 Reads

Isolated Monoarthritis.

Case Rep Infect Dis 2018 12;2018:9037657. Epub 2018 Jun 12.

Department of Medicine, University of Kentucky, Lexington, KY, USA.

is a rare cause of arthritis. Its course is indolent with lack of constitutional symptoms resulting in delayed presentation and diagnosis. It is a dimorphic fungus found ubiquitously in sphagnum moss, decaying vegetation, soil, and hay. Read More

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June 2018
12 Reads

Primary conjunctival sporotrichosis: An atypical presentation of the disease.

JAAD Case Rep 2018 Jun 7;4(5):497-499. Epub 2018 May 7.

Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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June 2018
6 Reads

Chronic Meningitis and Hydrocephalus due to in Immunocompetent Adults: A Challenging Entity.

Open Forum Infect Dis 2018 May 28;5(5):ofy081. Epub 2018 May 28.

Central Laboratory Division, LIM-03, Clinics Hospital, São Paulo University, São Paulo, Brazil.

Chronic meningitis caused by sp. is occasionally described in immunosuppressed patients. We report the challenges in diagnosing and managing 2 nonimmunocompromised patients with hydrocephalus and chronic meningitis caused by . Read More

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May 2018
1 Read

Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.

Respiration 2018 28;96(3):283-301. Epub 2018 Jun 28.

Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.

Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Read More

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June 2018
24 Reads

Dermoscopy in disseminated sporotrichosis.

J Eur Acad Dermatol Venereol 2018 Jun 28. Epub 2018 Jun 28.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

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A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis.

Eur J Dermatol 2018 Aug;28(4):558-559

China-Japan Union Hospital of Jilin University, 126 Xiantai St, Erdao, Changchun, Jilin 130033, China.

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August 2018
1 Read

Immunization, but Not Infection, Induces Protective Th17 Responses Mediated by Circulating Memory CD4 T Cells.

Front Microbiol 2018 12;9:1275. Epub 2018 Jun 12.

Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Sporotrichosis is a chronic subcutaneous mycosis caused by the species complex and it is considered an emerging opportunistic infection in countries with tropical and subtropical climates. The host's immune response has a main role in the development of this disease. However, it is unknown the features of the memory cellular immune response that could protect against the infection. Read More

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June 2018
4 Reads

A malar rash from inner Rio de Janeiro State, Brazil.

IDCases 2018 5;12:99-100. Epub 2018 Apr 5.

Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil.

A 49-year-old previously healthy woman from Rio de Janeiro State, Brazil, presented with a right malar rash that started as a tiny pustule and progressed to an ulcerated papulonodular lesion within ten weeks. A presumptive diagnosis of zoonotic sporotrichosis was made based on excellent response to treatment and epidemiological linkage with a diseased cat. Read More

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April 2018
4 Reads

Antifungal activity of diphenyl diselenide alone and in combination with itraconazole against Sporothrix brasiliensis.

Med Mycol 2018 Jun 19. Epub 2018 Jun 19.

Mycology Lab, Faculty of Medicine, Federal University of Rio Grande (FaMed-FURG), Rio Grande do Sul, Brazil.

Sporothrix brasiliensis is the main agent of feline and zoonotic sporotrichosis. Given the scarcity of options for sporotrichosis treatment and the promising activity of diphenyl diselenide (PhSe)2 against a diversity of fungal pathogens, this study aimed to evaluate the in vitro susceptibility of Sporothrix brasiliensis to (PhSe)2 alone and in combination with itraconazole (ITC). Forty clinical isolates of S. Read More

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June 2018
4 Reads

Dacryocystitis due to sporothrix inoculated vis an unusual mode: Case report.

Medicine (Baltimore) 2018 Jun;97(25):e11182

Department of Pathology, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, P.R. China.

Rationale: Sporotrichosis is the most common subcutaneous mycosis. It is caused by the dimorphic fungus Sporothrix schenckii. Ocular sporotrichosis is uncommon and has been rarely reported. Read More

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June 2018
11 Reads

Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia.

Genome Announc 2018 Jun 14;6(24). Epub 2018 Jun 14.

Cellular and Molecular Biology Unit, Corporación para Investigaciones Biológicas, Medellín, Colombia.

is a thermodimorphic fungal pathogen with a high genetic diversity. In this work, we present the assembly and similarity analysis of the whole-genome sequences of two clinical isolates from Colombia of . Read More

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June 2018
11 Reads

Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis.

Sci Rep 2018 Jun 13;8(1):9074. Epub 2018 Jun 13.

Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Read More

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June 2018
2 Reads

Proteins Potentially Involved in Immune Evasion Strategies in Elucidated by Ultra-High-Resolution Mass Spectrometry.

mSphere 2018 06 13;3(3). Epub 2018 Jun 13.

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

is the prevalent agent of a large zoonotic outbreak in Brazil. With the involvement of several thousands of cases, this is the largest cohort of human and animal sporotrichosis on record in the world. Infections are characterized by local cutaneous dissemination in humans without underlying disease. Read More

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June 2018
1 Read

Sporotrichosis: From KOH to Molecular Biology.

J Fungi (Basel) 2018 May 23;4(2). Epub 2018 May 23.

Histopathology Department, "Dr. Manuel Gea Gonzalez" General Hospital, Calz. de Tlalpan 4800, Belisario Domínguez Secc 16, Tlalpan, CDMX 14080, Mexico.

Sporotrichosis is a cosmopolitan, chronic granulomatous mycosis, acquired by traumatic inoculation and caused by . Several methods of diagnostic are available, from KOH to molecular biology. In this review, we describe from the simplest (clinical diagnosis) to the most advanced diagnostic techniques (molecular biology). Read More

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Endophthalmitis in patients co-infected by HIV and sporotrichosis: a systematic review of published case reports.

Eye (Lond) 2018 Oct 7;32(10):1678-1680. Epub 2018 Jun 7.

Dermatology department, Hospital General de México, Mexico City, Mexico.

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October 2018

Repeated Exposition to Mercury (II) Chloride Enhances Susceptibility to Infection in Mice.

J Fungi (Basel) 2018 May 25;4(2). Epub 2018 May 25.

Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jaú km 1, Araraquara 14800-903, Brazil.

Sporotrichosis is a subcutaneous mycosis that has re-emerged in several tropical and subtropical regions over the last decades. Growing findings suggest that the interplay of host, pathogen, and environment has a determinant effect on the diversity, local distribution, and virulence of , the etiologic agent. Among the environmental factors, we have studied the potential role of repeated exposures to mercury (Hg), a known immunotoxic xenobiotic that is widely used in gold mining regions where sporotrichosis outbreaks are frequently reported. Read More

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May 2018
2 Reads

Nodular Lymphangitis (Sporotrichoid Lymphocutaneous Infections). Clues to Differential Diagnosis.

J Fungi (Basel) 2018 May 9;4(2). Epub 2018 May 9.

Dermatology Service & Mycology Department, Hospital General de Mexico, "Dr. Eduardo Liceaga", Balmis 148, Colonia Doctores, Ciudad de México 06726, Mexico.

Nodular lymphangitis, also known as sporotrichoid lymphocutaneous infections, is characterized by suppurative inflammatory nodules along the lymphatic vessels. This manifestation is classic of sporotrichosis, however, other infections such as nocardiosis, atypical mycobacteriosis, leishmaniasis, among others, can also express this clinical pattern. Sporotrichosis, which often occurs in gardeners, remains the most recognized cause of nodular lymphangitis. Read More

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May 2018
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