Search Our Scientific Publications & Authors

Infect Drug Resist 2021 3;14:2059-2072. Epub 2021 Jun 3.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, 36050, México.

Background: Sporotrichosis is an increasing threat for humans, affecting mainly skin and subcutaneous tissues but that can cause disseminated infection in immunocompromised patients. , and are the main etiological agents of this mycosis, and each species show different virulence levels. The gold standard to assess fungal virulence is the mouse model that is expensive and time-consuming. Read More

Infez Med 2021 Jun;29(2):191-198

Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy.

Sporotrichosis is a fungal infection occurring worldwide, especially in tropical and sub-tropical areas. We present a brief review of clinical and epidemiological aspects of sporotrichosis, as well as its treatment. Sporotrichosis is rarely reported in Europe and the European Centre of Disease Control does not track its infection rate. Read More

J Pediatr 2021 Jun;233:226

Santa Casa de Sao Paulo School of Medical Sciences, São Paulo, Brazil.

Dermatol Online J 2021 Apr 15;27(4). Epub 2021 Apr 15.

Department of Dermatology, Máxima Medical Center Veldhoven, De Run 4600, 5500 MB, Veldhoven.

Sporothrix spp. cause the most common deep fungal skin infections in Brazil and this is related to infected cats. Transmission is traditionally from organic material/plants but can also be zoonotic. Read More

F1000Res 2020 29;9:654. Epub 2020 Jun 29.

Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 21040900, Brazil.

Sporotrichosis has recently emerged as an important mycosis worldwide, with diverse transmission and epidemiologic profiles. For instance, in Brazil most cases are related to zoonotic transmission from naturally infected cats, and the majority of cases in China are due to external injury with environmental materials. Publications on sporotrichosis and on its etiologic agent may guide the direction of the research in this field. Read More

JAAD Case Rep 2021 May 26;11:102-104. Epub 2021 Mar 26.

Department of Dermatology, University of California San Francisco, San Francisco, California.

Comp Immunol Microbiol Infect Dis 2021 Jun 22;76:101651. Epub 2021 Apr 22.

Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

An epidemiological characterization of animal sporotrichosis was carried out between 2017 and 2018, in a highly urbanized area in Brazil, including outcomes and the spatial distribution of the cases according to the health vulnerability index (HVI) of the study territory. One hundred and sixty-five cats and four dogs suspected of sporotrichosis were identified by a surveillance and control program previously implemented in the study area. One hundred and five of these animals (62. Read More

Ann Dermatol 2021 Feb 30;33(1):37-45. Epub 2020 Dec 30.

Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.

Background: Local hyperthermia is recommended for the treatment of patients with fixed cutaneous sporotrichosis, though the effectiveness and mechanisms of action remain elusive. While neutrophils represent the main inflammatory cells associated with sporotrichosis lesions, the issue of whether hyperthermia is involved with interactions between neutrophils and remains unclear.

Objective: To evaluate the effect of local hyperthermia on sporotrichosis and determine whether local hyperthermia involves effects of neutrophils against . Read More

Braz J Microbiol 2021 Apr 28. Epub 2021 Apr 28.

Programa de Pós Graduação em Ciências da Saúde, Laboratório de Micologia, Faculdade de Medicina (FAMED), Universidade Federal Do Rio Grande (FURG), Campus Saúde, Visconde de Paranaguá 102, Centro, Rio Grande, RS, 96201-900, Brazil.

We evaluated the in vitro susceptibility of Sporothrix schenckii s.str. and Sporothrix globosa to diphenyl diselenide (PhSe) alone and in association with itraconazole (ITZ). Read More

Indian J Med Res 2021 Mar;153(3):311-319

Department of Medical Microbiology; Center of Advanced Research in Medical Mycology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Fungal diseases have not been taken seriously in public health agendas as well as research priorities, despite of globally causing an estimated two million deaths every year, and the emergence of many troublesome fungal pathogens like Candida auris, azole resistant Aspergillus fumigatus, terbinafine and azole resistant dermatophytes, and zoonotic sporotrichosis in humans. Fungi are also responsible for huge losses of agricultural products and stored crops as well as recent massive and unexpected mortality in animals caused by white-nose syndrome in the bats and Chytridiomycosis in amphibians. This review aims to underscore the need for collaborative, multisectoral, and trans-disciplinary approach to include the One Health approach as an essential component of surveillance, prevention, and control of globally emerging fungal diseases. Read More

Med Mycol Case Rep 2021 Jun 26;32:50-52. Epub 2021 Mar 26.

Department of Dermatology, Faculty of Medicine, 101, Antananarivo, Madagascar.

Sporotrichosis is a frequent subcutaneous mycosis in Madagascar. Extracutaenous forms are exceptional and are usually seen in immunosuppressed hosts. We report a case of an aggressive clinical evolution of lymphocutaneous sporotrichosis with osteoarticular involvement in an immunocompetent patient. Read More

J Infect Public Health 2021 May 23;14(5):670-673. Epub 2021 Feb 23.

Facultad de Ciencias, Universidad Nacional de San Antonio Abad del Cusco (UNSAAC), Cusco, Peru.

To date, there have been no molecular typing studies to identify the Sporothrix species circulating in Abancay, a hyperendemic area of sporotrichosis in Peru. To identify six clinical isolates of the Sporothrix schenckii complex from Abancay, Peru, we used PCR-sequencing of the calmodulin gene, and a phylogenetic analysis was conducted with these and additional sequences from GenBank. All clinical isolates were identified as S. Read More

An Bras Dermatol 2021 May-Jun;96(3):349-351. Epub 2021 Mar 21.

Dermatology Clinic, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

Sporotrichosis is a subcutaneous mycosis that affects humans and animals, with a typically subacute or chronic evolution, caused by Sporothrix spp., a dimorphic fungus. Although the cutaneous form is the most frequent presentation, the ocular involvement has been more frequently diagnosed in endemic areas, affecting mainly children and the elderly. Read More

JAMA 2021 03;325(12):1230

J Appl Microbiol 2021 Mar 23. Epub 2021 Mar 23.

Faculty of Biological Sciences, Department of Mycology and Genetics, Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland.

Fungal infections are still underappreciated and their prevalence is underestimated, which renders them a serious public health problem. Realistic discussions about their distribution, symptoms, and control can improve management and diagnosis and contribute to refinement of preventive actions using currently available tools. This article represents an overview of dermatophytes and endemic fungi that cause infections in humans and animals. Read More

PLoS Negl Trop Dis 2021 Mar 17;15(3):e0009250. Epub 2021 Mar 17.

Pós-Graduação em Medicina Tropical, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Background: Bone sporotrichosis is rare. The metropolitan region of Rio de Janeiro is hyperendemic for zoonotic sporotrichosis and the bone presentations are increasing.

Methods: We studied a retrospective cohort of 41 cases of bone sporotrichosis, diagnosed from 1999-2016. Read More

GMS Ophthalmol Cases 2021 28;11:Doc02. Epub 2021 Jan 28.

Federal University of Rio de Janeiro, Campus Macaé (UFRJ), Rio de Janeiro, Brazil.

Parinaud's oculoglandular syndrome (POS) is a clinical condition characterized by granulomatous conjunctivitis associated with homolateral neck pain and anterior preauricular lymphadenopathy. Several reports of this condition occurred and some bacterial etiological agents were identified. However, fungal infections have also been associated, especially sporotrichosis. Read More

J Fungi (Basel) 2021 Feb 26;7(3). Epub 2021 Feb 26.

Cátedra de Enfermedades Infecciosas, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Buenos Aires C1427 CWN, Argentina.

Sporotrichosis, caused by and related species, is the most frequent implantation mycosis in Latin America. In Argentina, over the last 8 years, there have been 0.16 new cases per month of feline sporotrichosis in 2011, increasing to 0. Read More

An Bras Dermatol 2021 Mar-Apr;96(2):231-233. Epub 2021 Jan 31.

Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Sporotrichosis is a subcutaneous mycosis caused by dimorphic fungi of the genus Sporothrix. The authors report a case of fixed cutaneous sporotrichosis with therapeutic failure after 18 months of itraconazole and terbinafine associated with cryosurgery. The patient was cured after the introduction of saturated potassium iodide solution. Read More

Emerg Infect Dis 2021 Mar;27(3):949-952

We report the implementation of an animal sporotrichosis surveillance and control program that evaluates strategies to identify suspected and infected cats in a municipality in southeastern Brazil. All adopted measures reinforced the program, although strategies had different abilities to detect the presence of infection. Read More

Vet Ophthalmol 2021 Mar 19;24(2):209-215. Epub 2021 Feb 19.

Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Brasil.

Introduction: Classically, sporotrichosis occurs as a chronic granulomatous lymphocutaneous infection. The extracutaneous form is uncommon and may affect the eye without cutaneous involvement. The most frequent form of ocular sporotrichosis reported in humans is a granulomatous conjunctivitis. Read More

Braz J Microbiol 2021 Mar 18;52(1):1-3. Epub 2021 Feb 18.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.

An Bras Dermatol 2021 Mar-Apr;96(2):245-248. Epub 2021 Feb 5.

Dermatology Clinic, Santa Casa de Misericórdia de São Paulo, SP, Brazil.

Antimicrob Agents Chemother 2021 Feb 16. Epub 2021 Feb 16.

Laboratório de Glicobiologia de Eucariotos (LaGE), Depto. Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Sporotrichosis is an emerging mycosis caused by members of the genus The disease affects humans and animals, particularly cats, which plays an important role in the zoonotic transmission. Feline sporotrichosis treatment options include itraconazole (ITC), potassium iodide and amphotericin B, drugs usually associated with deleterious adverse reactions and refractoriness in cats, especially when using ITC. Thus, affordable, non-toxic and clinically effective anti- agents are needed. Read More

Clin Cosmet Investig Dermatol 2021 25;14:91-96. Epub 2021 Jan 25.

Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, People's Republic of China.

Purpose: This report describes a case of a skin sporotrichosis infection and the steps taken to identify an effective antifungal treatment.

Patients And Methods: A 50-year-old woman from Jilin province, China, presented complaining of a small mass that had been on her right upper eyelid for two years. A skin biopsy was taken and submitted for bacterial and mycological assessment. Read More

Mycopathologia 2021 May 23;186(2):313-314. Epub 2021 Jan 23.

Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Department of Dermatology and Venereology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, 100034, Beijing, People's Republic of China.

Foot (Edinb) 2021 Mar 13;46:101770. Epub 2021 Jan 13.

Microbiology Department, Universidad Autónoma De Nuevo León, Mexico.

Background: Deep mycoses and pseudomycoses (DMP) may cause significant disability and even death; however, the reports regarding these diseases, mainly affecting the foot, are scarce.

Objective: To describe the epidemiological, clinical, and diagnostic characteristics of DMP of the foot in 160 patients.

Methods: A retrospective and observational study of DMP affecting the foot was carried out in a tertiary-care center in Mexico for 20 years (from January 2000 to December 2019). Read More

Mycopathologia 2021 Mar 3;186(1):141-142. Epub 2021 Jan 3.

Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, Sichuan, China.

Dermatol Ther 2021 03 1;34(2):e14720. Epub 2021 Feb 1.

Department of Dermatology, The Second Hospital of Jilin University, Changchun, China.

Sporotrichosis is a fungal disease of the human and other mammals, caused by a complex of Sporothrix schenckii. The disease follows the traumatic inoculation to lead to fixed lesions, regional lymphangitic lesions, or even disseminated lesions including internal involvement, which depends on host immunological status and strain virulence. In this work, we observed the role of CD4 T cells apoptosis and conversion of Th1/Th2-type cytokines in the cellular immunity regulation on mice model sporotrichosis. Read More

Mycoses 2021 Apr 28;64(4):420-427. Epub 2020 Dec 28.

Infectious Diseases Postgraduate Program, Center for Research in Medical Mycology, Federal University of Espírito Santo (UFES), Espírito Santo, Brazil.

Background: Sporotrichosis is a subcutaneous mycosis caused by Sporothrix species that affects humans and animals. Little information on the genetic diversity and population structure of the pathogen is available for Brazil, which is needed to design effective strategies to tackle the advance of sporotrichosis in endemic areas.

Objectives: We assessed the genetic diversity and mating-type distribution of Sporothrix isolates recovered from human and feline cases of sporotrichosis in Espírito Santo-Brazil to better understand the population structure, epidemiology and diversification of this pathogen, as well as to explore the possible routes of transmission involved in the ongoing outbreaks. Read More