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    Successful Treatment of Canine Sporotrichosis with Terbinafine: Case Reports and Literature Review.
    Mycopathologia 2017 Dec 8. Epub 2017 Dec 8.
    Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.
    Sporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. Read More

    Proteases of Sporothrix schenckii: Cytopathological effects on a host-cell model.
    Rev Iberoam Micol 2017 Dec 5. Epub 2017 Dec 5.
    Laboratorio de Micología Básica, Unidad de Medicina Experimental, Facultad de Medicina, UNAM, Dr. Balmis No. 148, Col. Doctores, Del. Cuauhtémoc, Mexico, DF, Mexico.
    Background: Sporotrichosis is a fungal infection caused by the Sporothrix schenckii complex. The adhesion of the fungus to the host tissue has been considered the key step in the colonization and invasion, but little is known about the early events in the host-parasite interaction.

    Aims: To evaluate the proteolytic activity of S. Read More

    Lymphocutaneous Sporotrichosis Treated with Potassium Iodide with Development of Subclinical Hypothyroidism: Wolff-Chaikoff Effect?
    Indian Dermatol Online J 2017 Nov-Dec;8(6):475-477
    Department of Dermatology, Dr Ram Manohar Lohia Hospital, New Delhi, India.
    Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. Read More

    Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report.
    Med Mycol Case Rep 2018 Mar 28;19:18-20. Epub 2017 Oct 28.
    Postgraduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, Brazil.
    We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. Read More

    Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics.
    An Bras Dermatol 2017 Sep-Oct;92(5):606-620
    Dermatology Department, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro (FCM-UERJ), Rio de Janeiro, RJ, Brazil.
    In the late 90's there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. Read More

    AIDS-Related Endemic Mycoses in Western Cape, South Africa, and Clinical Mimics: A Cross-Sectional Study of Adults With Advanced HIV and Recent-Onset, Widespread Skin Lesions.
    Open Forum Infect Dis 2017 25;4(4):ofx186. Epub 2017 Aug 25.
    Division of Infectious Diseases and HIV Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, Western Cape, South Africa.
    Background: Skin lesions are common in advanced HIV infection and are sometimes caused by serious diseases like systemic mycoses (SM). AIDS-related SM endemic to Western Cape, South Africa, include emergomycosis (formerly disseminated emmonsiosis), histoplasmosis, and sporotrichosis. We previously reported that 95% of patients with AIDS-related emergomycosis had skin lesions, although these were frequently overlooked or misdiagnosed clinically. Read More

    Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count.
    Case Rep Infect Dis 2017 25;2017:4713140. Epub 2017 Sep 25.
    Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Tijuca, 20270-004 Rio de Janeiro, RJ, Brazil.
    Sporotrichosis is a human and animal disease caused by species of the Sporothrix schenckii complex. It is classically acquired through traumatic inoculation of fungal elements. Most frequently, sporotrichosis presents as a fixed cutaneous or as a lymphocutaneous form. Read More

    Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model.
    Med Mycol 2017 Oct 26. Epub 2017 Oct 26.
    School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, SP, Brazil.
    This report describes a model of host resistance for Sporothrix schenckii, an opportunistic fungi in immunosuppressed mice with cyclophosphamide (CY) to be used in studies of immunotoxicology and immunopharmacology. Two doses of CY were administered intraperitoneally: 200 mg/kg and a booster of 150 mg/kg at 9-day intervals. Three days after the first dose of CY the animals were infected subcutaneously with 1. Read More

    Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus).
    J Eur Acad Dermatol Venereol 2017 Oct 28. Epub 2017 Oct 28.
    Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - RJ, 21040-360, Brazil.

    Cavitary Pulmonary Sporotrichosis: Case Report and Literature Review.
    Mycopathologia 2017 Dec 23;182(11-12):1119-1123. Epub 2017 Oct 23.
    Departamento de Micología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, CONICET, Resistencia, Argentina.
    A case of cavitary pulmonary sporotrichosis without mucocutaneous involvement caused by Sporothrix schenckii is reported in a sexagenarian woman with a long smoking history. The patient was hospitalized for septic shock with multiorgan failure from a respiratory focus. The diagnosis was delayed due to the fungal etiological agent was not initially considered in the differential diagnosis. Read More

    Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis.
    Case Rep Dermatol 2017 May-Aug;9(2):119-129. Epub 2017 Aug 17.
    Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. Read More

    An unusual cutaneous infection caused by Mycobacterium marinum.
    JMM Case Rep 2017 Apr 12;4(4):e005088. Epub 2017 Apr 12.
    Department of Health Science, University of Eastern Piedmont, Novara, Italy.
    Introduction.Mycobacterium marinum is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. Case presentation. Read More

    Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China.
    Emerg Microbes Infect 2017 Oct 11;6(10):e88. Epub 2017 Oct 11.
    Department of Dermatology and Venereology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
    Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. Read More

    In silico analysis of cytochrome P450 monooxygenases in chronic granulomatous infectious fungus Sporothrix schenckii: Special focus on CYP51.
    Biochim Biophys Acta 2018 Jan 5;1866(1):166-177. Epub 2017 Oct 5.
    Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa. Electronic address:
    Sporotrichosis is an emerging chronic, granulomatous, subcutaneous, mycotic infection caused by Sporothrix species. Sporotrichosis is treated with the azole drug itraconazole as ketoconazole is ineffective. It is a well-known fact that azole drugs act by inhibiting cytochrome P450 monooxygenases (P450s), heme-thiolate proteins. Read More

    Clotrimazole is highly effective in vitro against feline Sporothrix brasiliensis isolates.
    J Med Microbiol 2017 Nov 6;66(11):1573-1580. Epub 2017 Oct 6.
    1​Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Purpose: Sporothrix brasiliensis, the most virulent species in the Sporothrix schenckii complex, is responsible for the ongoing epidemics of human and animal sporotrichosis in Brazil. Feline outbreaks are usually driven by S. brasiliensis and followed by extensive transmission to humans. Read More

    Differences in clinical ocular outcomes between exogenous and endogenous endophthalmitis caused by Sporothrix: a systematic review of published literature.
    Br J Ophthalmol 2017 Sep 28. Epub 2017 Sep 28.
    Medicine School, Universidad Nacional Mayor de San Marcos, Lima, Peru.
    Background: Sporotrichosis is an implantation mycosis caused by Sporothrix species prevalent worldwide, which occasionally can also result in intraocular infection presenting as an exogenous or endogenous infection (disseminated sporotrichosis). Knowledge in its clinical recognition and management is limited.

    Aims: To systematically review and analyse data from published literature with a view to comparing clinical outcomes between exogenous and endogenous endophthalmitis caused by Sporothrix. Read More

    Tacrolimus Increases the Effectiveness of Itraconazole and Fluconazole against Sporothrix spp.
    Front Microbiol 2017 15;8:1759. Epub 2017 Sep 15.
    Laboratório de Bioquímica Microbiana, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Goés, Universidade Federal do Rio de JaneiroRio de Janeiro, Brazil.
    Calcineurin inhibitors - such as the clinically used drug tacrolimus - are active against important fungal pathogens, particularly when combined with azoles. However, tacrolimus has not been tested against sporotrichosis, an endemic subcutaneous mycosis with worldwide distribution. Here, we evaluated the activity of tacrolimus and cyclosporine A in vitro - as monotherapy and in combination with itraconazole or fluconazole - against yeasts of Sporothrix brasiliensis and S. Read More

    Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex.
    Rev Soc Bras Med Trop 2017 Jul-Aug;50(4):554-557
    Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
    Introduction:: We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.

    Methods:: Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen. Read More

    The Sporothrix schenckii Gene Encoding for the Ribosomal Protein L6 Has Constitutive and Stable Expression and Works as an Endogenous Control in Gene Expression Analysis.
    Front Microbiol 2017 1;8:1676. Epub 2017 Sep 1.
    División de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de GuanajuatoGuanajuato, Mexico.
    Sporothrix schenckii is one of the causative agents of sporotrichosis, a worldwide-distributed mycosis that affects humans and other mammals. The interest in basic and clinical features of this organism has significantly increased in the last years, yet little progress in molecular aspects has been reported. Gene expression analysis is a set of powerful tools that helps to assess the cell response to changes in the extracellular environment, the genetic networks controlling metabolic pathways, and the adaptation to different growth conditions. Read More

    The Current Status of Feline Sporotrichosis in Malaysia.
    Med Mycol J 2017 ;58(3):E107-E113
    Former Han Veterinary Surgery.
    Feline sporotrichosis has been reported in Malaysia since the 1990's. Since then, studies have revealed that clinical clade D, Sporothrix schenckii sensu stricto, of a single clonal strain is the most common cause of this disease in Malaysia. The prevalence of a single clonal strain from a clinical clade was never before reported in Asia in a specific geographical niche. Read More

    Exploring virulence and immunogenicity in the emerging pathogen Sporothrix brasiliensis.
    PLoS Negl Trop Dis 2017 Aug 30;11(8):e0005903. Epub 2017 Aug 30.
    Department of Medicine, Discipline of Infectious Diseases, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
    Sporotrichosis is a polymorphic chronic infection of humans and animals classically acquired after traumatic inoculation with soil and plant material contaminated with Sporothrix spp. propagules. An alternative and successful route of transmission is bites and scratches from diseased cats, through which Sporothrix yeasts are inoculated into mammalian tissue. Read More

    Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar.
    J Mycol Med 2017 Sep 25;27(3):312-324. Epub 2017 Aug 25.
    Laboratoire de parasitologie-mycologie, CHU de Grenoble-Alpes, CS 10217, 38043 Grenoble cedex 9, France; Laboratoire TIMC-IMAG TheREx, université de Grenoble-Alpes, domaine de la Merci, 38706 La Tronche cedex, France. Electronic address:
    Chromoblastomycosis and sporotrichosis are endemic fungal infections of tropical and subtropical regions, including Madagascar. The causal fungi develop in the soil or on plants and infect humans through wounds, either directly (wounding by the plant, through thorns, for example), or through the contact of an existing wound with contaminated soil. For this reason, the lesions predominantly occur on the limbs, and these fungi principally infect people working outside with bare hands and/or feet. Read More

    Neglected endemic mycoses.
    Lancet Infect Dis 2017 Nov 31;17(11):e367-e377. Epub 2017 Jul 31.
    Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
    Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Read More

    A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia.
    IDCases 2017 29;9:70-72. Epub 2017 Jun 29.
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of Florida, Gainesville, FL, United States.
    Sporothrix schenckii is a pathogen with a predilection for dissemination in immunocompromised individuals, often with HIV. We report a case of disseminated sporotrichosis in an unfortunate 25 year old male (without HIV) who was originally treated for presumed pneumonia. The patient continued to worsen clinically and further work-up eventually revealed Sporothrix schenckii species with involvement of multiple organs including the skin, heart, lungs and bone marrow. Read More

    Sporotrichosis in a liver transplant patient: A case report and literature review.
    Med Mycol Case Rep 2017 Sep 20;17:25-27. Epub 2017 Jun 20.
    Department of Liver Transplant, Hospital de Base de São José do Rio Preto, São José do Rio Preto, Brazil.
    The liver transplant patient was admitted to the hospital with hyperemic, granulomatous, ulcerated lesion in the anterior compartment of the right lower limb with report of local trauma. The agent Sporothrix schenckii was isolated from biopsy of the lesion and lymph nodes of the right lower limb. In this case, the treatment was difficult because the patient has severe pulmonary hypertension and took the following drugs: warfarin, sildenafil, and tacrolimus. Read More

    Chemical composition and cytotoxicity of extracts of marjoram and rosemary and their activity against Sporothrix brasiliensis.
    J Med Microbiol 2017 Jul 12;66(7):1076-1083. Epub 2017 Jul 12.
    4​Department of Pharmacology, Institute of Basic Sciences and Health, Federal University of Rio Grande do Sul, Porto Alegre/RS, Brazil.
    Purpose: Motivated by increasing reports of antifungal resistance in human and animal sporotrichosis, this study evaluated the chemical composition, cytotoxicity and anti-Sporothrix brasiliensis activity of extracts of marjoram (Origanum majorana) and rosemary (Rosmarinus officinalis).

    Methodology: Ten (INF10) and 60 min (INF60) infusions, a decoction and a hydroalcoholic extract (HAE, 70 %) were prepared from both plants (10 % w/v). The extract composition was analysed by liquid chromatography/mass spectrometry and the cytotoxicity was evaluated using a colorimetric assay in canine and feline kidney cells. Read More

    Comparative efficacy and toxicity of two vaccine candidates against Sporothrix schenckii using either Montanide™ Pet Gel A or aluminum hydroxide adjuvants in mice.
    Vaccine 2017 Aug 4;35(34):4430-4436. Epub 2017 Jul 4.
    São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, SP, Brazil. Electronic address:
    Sporotrichosis is an important zoonosis in Brazil and the most frequent subcutaneous mycosis in Latin America, caused by different Sporothrix species. Currently, there is no effective vaccine available to prevent this disease. In this study, the efficacy and toxicity of the adjuvant Montanide™ Pet Gel A (PGA) formulated with S. Read More

    Molecular identification and phenotypic characterisation of Sporothrix globosa from clinical cases of Eastern Assam, North-east India.
    Indian J Med Microbiol 2017 Apr-Jun;35(2):269-273
    Department of Microbiology, Assam Medical College and Hospital, Dibrugarh, Assam, India.
    Sporotrichosis is known to be endemic in the state of Assam, North-east India, which is situated in the Sub-Himalayan region. This disease is an acute or chronic infection caused by Sporothrix schenckii species complex which currently includes several species of clinical relevance such as Sporothrix brasiliensis, Sporothrix globosa, Sporothrix schenckii sensu stricto, Sporothrix albicans, Sporothrix mexicana, Sporothrix pallida and Sporothrix luriei. S. Read More

    Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.
    Int J Dermatol 2017 Oct 3;56(10):1037-1045. Epub 2017 Jul 3.
    Medicine School, Universidad Peruana Cayetano Heredia, Lima, Peru.
    Background: There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs.

    Objectives: This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses.

    Methods: We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. Read More

    Dectin-1 expression by macrophages and related antifungal mechanisms in a murine model of Sporothrix schenckii sensu stricto systemic infection.
    Microb Pathog 2017 Sep 20;110:78-84. Epub 2017 Jun 20.
    Department of Clinical Analysis, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University " Júlio de Mesquita Filho " - UNESP, Araraquara, SP, Brazil. Electronic address:
    The available information about the role of Dectin-1 in sporotrichosis is scarce. Hence, we aimed to assess Dectin-1 expression by macrophages and the activation of some related antifungal mechanisms during the Sporothrix schenckii sensu stricto infection as a first attempt to elucidate the role of this receptor in sporotrichosis. Balb/c mice were intraperitoneally infected with S. Read More

    Antifungal susceptibility of Sporothrix schenckii complex biofilms.
    Med Mycol 2017 Jun 8. Epub 2017 Jun 8.
    Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Department of Pathology and Legal Medicine, Federal University of Ceará, Ceará, Brazil.
    Sporotrichosis, caused by species of Sporothrix schenckii complex, is the most prevalent subcutaneous mycosis in many areas of Latin America. The aim of this study was to evaluate the ability of Sporothrix spp. to form biofilms in vitro and to characterize the growth kinetics, morphology, and antifungal susceptibility of biofilms against classical antifungals. Read More

    Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil.
    Rev Inst Med Trop Sao Paulo 2017 Jun 1;59:e33. Epub 2017 Jun 1.
    Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway.

    Aims: To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL).

    Methods: From January 2004 to December 2010, 23 cases of SL (4. Read More

    Efficacy of a poly-aggregated formulation of amphotericin B in treating systemic sporotrichosis caused by Sporothrix brasiliensis.
    Med Mycol 2017 Jun 1. Epub 2017 Jun 1.
    Laboratory of Cellular Mycology and Proteomics, Department of Cell Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
    In severe cases of sporotrichosis, it is recommended to use amphotericin B deoxycholate (D-AMB) or its lipid formulations and/or in association with itraconazole (ITC). Our aim was to evaluate the antifungal efficacy of a poly-aggregated amphotericin B (P-AMB), a nonlipid formulation, compared with D-AMB on systemic sporotrichosis caused by Sporothrix brasiliensis. In vitro assays showed that Sporothrix schenckii sensu stricto and S. Read More

    Practical Management of Deep Cutaneous Fungal Infections.
    Med Mycol J 2017 ;58(2):E71-E77
    Department of Dermatology, Kitasato University Kitasato Institute Hospital.
    Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining. Read More

    Sporothrix schenckii sensu stricto and Sporothrix brasiliensis Are Differentially Recognized by Human Peripheral Blood Mononuclear Cells.
    Front Microbiol 2017 10;8:843. Epub 2017 May 10.
    Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de GuanajuatoGuanajuato, Mexico.
    Sporothrix schenckii sensu stricto and S. brasiliensis are usually associated to sporotrichosis, a subcutaneous mycosis worldwide distributed. Comparative analyses between these two species indicate they contain genetic and physiological differences that are likely to impact the interaction with host cells. Read More

    Sporotrichal Tenosynovitis Diagnosed Helpfully by Musculoskeletal Ultrasonography.
    Intern Med 2017 15;56(10):1243-1246. Epub 2017 May 15.
    Department of Clinical Research, Osaka Minami Medical Center, Japan.
    A 72-year-old man presented with persistent oligoarthritis and positive results for rheumatoid factor and was suspected of having rheumatoid arthritis (RA). However, the musculoskeletal ultrasonography (MSUS) findings were not consistent with those of typical RA. He had undergone surgery for carpal tunnel syndrome, which allowed both histopathological and microbiological examinations to be performed. Read More

    Fungal infection control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosis.
    Braz J Biol 2017 Nov 4;77(4):848-855. Epub 2017 May 4.
    Department of Clinical Analysis, School of Pharmaceutical Sciences, Universidade Estadual Paulista "Júlio de Mesquita Filho" - UNESP, Rodovia Araraquara-Jaú, Km 1, CEP 14801-902, Araraquara, SP, Brazil.
    Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. Read More

    Sporotrichosis among children of a hyperendemic area in Peru: an 8-year retrospective study.
    Int J Dermatol 2017 Aug 9;56(8):868-872. Epub 2017 May 9.
    Medicine School, Universidad Nacional Mayor de San Marcos, Lima, Peru.
    Background: The clinical and epidemiologic characteristics of pediatric sporotrichosis are poorly understood.

    Objective: To describe the incidence and clinical characteristics of cases of sporotrichosis in children 14 years of age and younger reported in Abancay from 2004 to 2011, stratified according to age.

    Methods: We performed a retrospective review of pediatric patients 14 years of age and younger who were diagnosed with sporotrichosis in a referral center at Abancay, a poor area located in the south central highlands of Peru, to estimate the incidence rates (per 100,000 person-years) according to age and sporotrichosis type (lymphocutaneous and fixed), and clinical characteristics of these patients. Read More

    Polar Origanum vulgare (Lamiaceae) extracts with antifungal potential against Sporothrix brasiliensis.
    Med Mycol 2017 May 6. Epub 2017 May 6.
    Department of Preventive Veterinary, Federal University of Pelotas, Pelotas, RS, Brazil.
    Oregano (Origanum vulgare) has anti-Sporothrix spp. activity, including against strains that are resistant to antifungal drugs. As the studies are limited to the essential oil, the aim of this study was to evaluate the chemical, antioxidant and cytotoxic properties of polar oregano extracts and their anti-Sporothrix brasiliensis activity. Read More

    In vitro susceptibility of Sporothrix brasiliensis: Comparison of yeast and mycelial phases.
    Med Mycol 2017 Nov;55(8):869-876
    Post-Graduation Program in Health Science, Federal University of Rio Grande (FURG), Rio Grande, Brazil.
    Sporothrix brasiliensis has emerged as an important cause of sporotrichosis, particularly associated with feline and zoonotic cases. Owing to the paucity of data on antifungal activity against this species, the present study aimed to evaluate the in vitro susceptibility of clinical isolates of S. brasiliensis in the mycelial and yeast phases to itraconazole (ITZ), terbinafine (TRB), and amphotericin B (AMB). Read More

    Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis.
    Mem Inst Oswaldo Cruz 2017 May;112(5):376-381
    Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Micologia, Rio de Janeiro, RJ, Brasil.
    Background: Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. Read More

    Unique case report of a chromomycosis and Listeria in soft tissue and cerebellar abscesses after kidney transplantation.
    BMC Infect Dis 2017 Apr 20;17(1):288. Epub 2017 Apr 20.
    Département d'Urologie, Néphrologie et Transplantation, AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix. 47-83, Bd de l'Hôpital, 75013, Paris, France.
    Background: Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique association of abscesses caused by a chromomycosis and Listeria monocytogenes in a kidney transplant recipient, and didactically expose how the appropriate diagnosis was reached. Read More

    Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis: is it a good antigen for serological diagnosis of paracoccidioidomycosis?
    Braz J Med Biol Res 2017 Apr 3;50(4):e5928. Epub 2017 Apr 3.
    Departamento de Biologia, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
    Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. Read More

    Origin and distribution of Sporothrix globosa causing sapronoses in Asia.
    J Med Microbiol 2017 May 22;66(5):560-569. Epub 2017 May 22.
    4​Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands 2​Biological Sciences Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
    Purpose: The aim of the study was to evaluate the main sources and epidemiological patterns and speculate on the evolutionary origin of Sporothrix globosa in Asia.

    Methodology: Case and case series literature on sporotrichosis in Asia from January 2007 onwards were reviewed using meta-analysis. Phylogenetic analysis of relevant S. Read More

    The Efficacy of Humanized Antibody against the Sporothrix Antigen, gp70, in Promoting Phagocytosis and Reducing Disease Burden.
    Front Microbiol 2017 3;8:345. Epub 2017 Mar 3.
    Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo São Paulo, Brazil.
    Sporotrichosis is a subcutaneous mycosis distributed worldwide and is frequently reported in countries with tropical climates, as Latin America countries. We previously demonstrated that mice with sporotrichosis produce specific antibodies against a 70-kDa fungal protein, indicating that specific antibodies against this molecule may help to control the sporotrichosis. IgG1 monoclonal antibody was generated, and called mAbP6E7, in mice against a 70-kDa glycoprotein (gp70) of S. Read More

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