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    Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women.
    PLoS Negl Trop Dis 2018 Apr 23;12(4):e0006434. Epub 2018 Apr 23.
    Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
    Background: Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Read More

    [Auricular sporotrichosis. Atypical case report simulating bacterial cellulitis].
    Rev Chilena Infectol 2018;35(1):83-87
    Departamento de Micología, Hospital General de México Dr. Eduardo Liceaga, México.
    Sporotrichosis is the most common subcutaneous or implantation mycosis in Mexico. The case of a preauricular cutaneous-fixed sporotrichosis simulating atypical bacterial cellulitis is reported in an elderly patient with no history of trauma. The biopsy showed a suppurative granuloma with scarce yeast. Read More

    A Diabetic Elderly Man with Finger Ulcer.
    Korean J Fam Med 2018 Mar 22;39(2):126-129. Epub 2018 Mar 22.
    Dermatology Department, Hospital Raja Perempuan Zainab 2, Kelantan, Malaysia.
    Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. Read More

    Fungal diseases in children and adolescents in a referral centre in Bogota, Colombia.
    Mycoses 2018 Mar 30. Epub 2018 Mar 30.
    Dermatology Resident, Fundación Universitaria Sanitas, Centro Dermatológico Federico Lleras Acosta, E.S.E, Bogotá, D.C, Colombia.
    A cross-sectional descriptive study was conducted at a dermatology referral centre in Bogotá to estimate the frequencies and aetiologies of mycoses in the population under 18 years of age attending the medical mycology laboratory over a 13-year period (2000-2012). A total of 1337 samples from 1221 patients were evaluated, involving direct examination and culture for 1279 samples, direct examination alone for 50 and culture alone for 8. During the study period, dermatophytosis was diagnosed via culture in 537 cases (40. Read More

    The Infection Returns: A Case of Pulmonary Sporotrichosis Relapse after Chemotherapy.
    Case Rep Med 2018 18;2018:1384029. Epub 2018 Feb 18.
    Section of Pulmonary, Critical Care, and Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
    Background: Pulmonary sporotrichosis is a rare disease caused by a dimorphic fungus, . It is rarely found in association with malignancy. We present a case of pulmonary sporotrichosis recurrence after chemotherapy. Read More

    Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents.
    Med Mycol 2018 Apr;56(suppl_1):126-143
    Westerdijk Fungal Biodiversity Institute, Utrecht, and Center of Expertise in Mycology of Radboudumc/CWZ, Nijmegen, The Netherlands.
    The description of cryptic species with different pathogenic potentials has changed the perspectives on sporotrichosis. Sporothrix schenckii causes a benign chronic subcutaneous mycosis, Sporothrix brasiliensis is highly virulent, and Sporothrix globosa mainly causes fixed cutaneous lesions. Furthermore, S. Read More

    Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers.
    PLoS Negl Trop Dis 2018 Mar 9;12(3):e0006169. Epub 2018 Mar 9.
    MRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
    Sporotrichosis is a subcutaneous mycosis caused by pathogenic species of the Sporothrix genus. A new emerging species, Sporothrix brasiliensis, is related to cat-transmitted sporotrichosis and has severe clinical manifestations. The cell wall of pathogenic fungi is a unique structure and impacts directly on the host immune response. Read More

    An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis.
    Sci Rep 2018 Mar 8;8(1):4192. Epub 2018 Mar 8.
    Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analysis, University of Sao Paulo, Sao Paulo, Brazil.
    Sporothrix brasiliensis is the most virulent fungus of the Sporothrix complex and is the main species recovered in the sporotrichosis zoonotic hyperendemic area in Rio de Janeiro. A vaccine against S. brasiliensis could improve the current sporotrichosis situation. Read More

    Functional characterization of the Sporothrix schenckii Ktr4 and Ktr5, mannosyltransferases involved in the N-linked glycosylation pathway.
    Res Microbiol 2018 Apr 21;169(3):188-197. Epub 2018 Feb 21.
    Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P. 36050, Guanajuato Gto., Mexico. Electronic address:
    Sporothrix schenckii is one of the causative agents of the deep-seated mycosis sporotrichosis, a fungal infection with worldwide distribution. Fungus-specific molecules and biosynthetic pathways are potential targets for the development of new antifungal drugs. The MNT1/KRE2 gene family is a group of genes that encode fungus-specific Golgi-resident mannosyltransferases that participate in the synthesis of O-linked and N-linked glycans. Read More

    Synthesis And Antifungal Activity of Coumarins Derivatives against Sporothrix spp.
    Curr Top Med Chem 2018 Feb 20. Epub 2018 Feb 20.
    Universidade Federal Fluminense, Instituto de Quimica, Departamento de Quimica Organica, Niteroi, RJ, 24020-150. Brazil.
    Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. Read More

    Disseminated cutaneous sporotrichosis presenting as a necrotic facial mass: Case and review.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Department of Dermatology, University of California Davis Health System, Sacramento, California.
    Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii, a group of common saprophytes of soil, plants, and organic debris. Disseminated forms may be seen in the setting of immunosuppression and are typically treated initially with intravenous lipidized amphotericin B. We report an unusual case of a 65-year-old woman who developed disseminated cutaneous sporotrichosis with extensive facial involvement in the absence of a known primary inoculation. Read More

    Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis.
    Sci Rep 2018 Feb 13;8(1):2898. Epub 2018 Feb 13.
    Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.
    The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. Read More

    Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area.
    Mem Inst Oswaldo Cruz 2018 Mar;113(3):185-196
    Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Rio de Janeiro, RJ, Brasil.
    Background: Sporotrichosis is caused by species of the genus Sporothrix. From 1998 to 2015, 4,703 cats were diagnosed at the Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Even after the description of the Sporothrix species, the characterisation of feline isolates is not performed routinely. Read More

    A population genetics analysis in clinical isolates of Sporothrix schenckii based on calmodulin and calcium/calmodulin-dependent kinase partial gene sequences.
    Mycoses 2018 Feb 2. Epub 2018 Feb 2.
    Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.
    Sporotrichosis is a subcutaneous mycosis that is caused by diverse species of Sporothrix. High levels of genetic diversity in Sporothrix isolates have been reported, but few population genetics analyses have been documented. To analyse the genetic variability and population genetics relations of Sporothrix schenckii Mexican clinical isolates and to compare them with other reported isolates. Read More

    Epidemiology of fungal infections in China.
    Front Med 2018 Feb 11;12(1):58-75. Epub 2018 Jan 11.
    Shanghai Key Laboratory of Molecular Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
    With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. Read More

    Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.
    J Fungi (Basel) 2017 Feb 10;3(1). Epub 2017 Feb 10.
    Dermatology Service, Mycology Department, Hospital General de México "Eduardo Liceaga", Balmis 148, Colonia Doctores, CP: 03020. Cd. de México, México.
    Sporotrichosis is an implantation or inoculation mycosis caused by species of complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are () and . Read More

    Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations.
    BMC Vet Res 2018 Jan 18;14(1):19. Epub 2018 Jan 18.
    Medical and Molecular Mycology Laboratory, Microbiology and Parasitology Department, Biomedical Institute, Fluminense Federal University (UFF), Rua Prof. Hernani Melo, 101 São Domingos, Niterói, RJ, CEP: 24210-130, Brazil.
    Background: Sporotrichosis is a neglected zoonosis caused by pathogenic fungi belonging to the Sporothrix schenckii complex. In Rio de Janeiro state, this disease reached an epidemic status with over 4700 domestic felines and around 4000 humans affected since the mid-90s. The present study evaluated clinical and epidemiological aspects and also the frequency of colonization and infection by these fungi in healthy cats and among those with suspicious cutaneous lesions, inhabiting four Rio de Janeiro state distinct areas. Read More

    Disseminated cutaneous sporotrichosis in patient with alcoholism.
    Rev Soc Bras Med Trop 2017 Nov-Dec;50(6):871-873
    Departamento de Dermatologia, Hospital Universitário de Santa Maria, Santa Maria, RS, Brasil.
    Sporotrichosis is the most prevalent subcutaneous mycosis and is characterized by a subacute or chronic development of a cutaneous or subcutaneous nodular lesion. It is caused by the dimorphic fungus Sporothrix spp, which may manifest in different clinical forms. The disseminated cutaneous form is uncommon and is more likely to occur in immunocompromised patients. Read More

    Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas.
    Am J Ophthalmol Case Rep 2017 Dec 23;8:35-38. Epub 2017 Sep 23.
    Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
    Purpose: Sporotrichosis is a subcutaneous mycosis caused by sp., a dimorphic fungus. Although the cutaneous form is the most frequent form, the ocular presentation has been increasingly diagnosed in epidemic areas. Read More

    Successful Treatment of Canine Sporotrichosis with Terbinafine: Case Reports and Literature Review.
    Mycopathologia 2018 Apr 8;183(2):471-478. Epub 2017 Dec 8.
    Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.
    Sporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. Read More

    Proteases of Sporothrix schenckii: Cytopathological effects on a host-cell model.
    Rev Iberoam Micol 2018 Jan - Mar;35(1):32-38. Epub 2017 Dec 6.
    Laboratorio de Micología Básica, Unidad de Medicina Experimental, Facultad de Medicina, UNAM, Dr. Balmis No. 148, Col. Doctores, Del. Cuauhtémoc, Mexico, DF, Mexico.
    Background: Sporotrichosis is a fungal infection caused by the Sporothrix schenckii complex. The adhesion of the fungus to the host tissue has been considered the key step in the colonization and invasion, but little is known about the early events in the host-parasite interaction.

    Aims: To evaluate the proteolytic activity of S. Read More

    Lymphocutaneous Sporotrichosis Treated with Potassium Iodide with Development of Subclinical Hypothyroidism: Wolff-Chaikoff Effect?
    Indian Dermatol Online J 2017 Nov-Dec;8(6):475-477
    Department of Dermatology, Dr Ram Manohar Lohia Hospital, New Delhi, India.
    Sporotrichosis is a subcutaneous mycotic infection caused by that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. Read More

    Sporotrichosis by senso stricto with itraconazole resistance and terbinafine sensitivity observed and : Case report.
    Med Mycol Case Rep 2018 Mar 28;19:18-20. Epub 2017 Oct 28.
    Postgraduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, Brazil.
    We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. Read More

    Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics.
    An Bras Dermatol 2017 Sep-Oct;92(5):606-620
    Dermatology Department, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro (FCM-UERJ), Rio de Janeiro, RJ, Brazil.
    In the late 90's there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. Read More

    AIDS-Related Endemic Mycoses in Western Cape, South Africa, and Clinical Mimics: A Cross-Sectional Study of Adults With Advanced HIV and Recent-Onset, Widespread Skin Lesions.
    Open Forum Infect Dis 2017 25;4(4):ofx186. Epub 2017 Aug 25.
    Division of Infectious Diseases and HIV Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, Western Cape, South Africa.
    Background: Skin lesions are common in advanced HIV infection and are sometimes caused by serious diseases like systemic mycoses (SM). AIDS-related SM endemic to Western Cape, South Africa, include emergomycosis (formerly disseminated emmonsiosis), histoplasmosis, and sporotrichosis. We previously reported that 95% of patients with AIDS-related emergomycosis had skin lesions, although these were frequently overlooked or misdiagnosed clinically. Read More

    Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count.
    Case Rep Infect Dis 2017 25;2017:4713140. Epub 2017 Sep 25.
    Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Tijuca, 20270-004 Rio de Janeiro, RJ, Brazil.
    Sporotrichosis is a human and animal disease caused by species of the complex. It is classically acquired through traumatic inoculation of fungal elements. Most frequently, sporotrichosis presents as a fixed cutaneous or as a lymphocutaneous form. Read More

    Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model.
    Med Mycol 2017 Oct 26. Epub 2017 Oct 26.
    School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, SP, Brazil.
    This report describes a model of host resistance for Sporothrix schenckii, an opportunistic fungi in immunosuppressed mice with cyclophosphamide (CY) to be used in studies of immunotoxicology and immunopharmacology. Two doses of CY were administered intraperitoneally: 200 mg/kg and a booster of 150 mg/kg at 9-day intervals. Three days after the first dose of CY the animals were infected subcutaneously with 1. Read More

    Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus).
    J Eur Acad Dermatol Venereol 2018 Apr 22;32(4):e157-e158. Epub 2017 Nov 22.
    Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - RJ, 21040-360, Brazil.

    Cavitary Pulmonary Sporotrichosis: Case Report and Literature Review.
    Mycopathologia 2017 Dec 23;182(11-12):1119-1123. Epub 2017 Oct 23.
    Departamento de Micología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, CONICET, Resistencia, Argentina.
    A case of cavitary pulmonary sporotrichosis without mucocutaneous involvement caused by Sporothrix schenckii is reported in a sexagenarian woman with a long smoking history. The patient was hospitalized for septic shock with multiorgan failure from a respiratory focus. The diagnosis was delayed due to the fungal etiological agent was not initially considered in the differential diagnosis. Read More

    Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis.
    Case Rep Dermatol 2017 May-Aug;9(2):119-129. Epub 2017 Aug 17.
    Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. Read More

    An unusual cutaneous infection caused by .
    JMM Case Rep 2017 Apr 12;4(4):e005088. Epub 2017 Apr 12.
    Department of Health Science, University of Eastern Piedmont, Novara, Italy.
    is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis. Read More

    Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China.
    Emerg Microbes Infect 2017 Oct 11;6(10):e88. Epub 2017 Oct 11.
    Department of Dermatology and Venereology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
    Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. Read More

    In silico analysis of cytochrome P450 monooxygenases in chronic granulomatous infectious fungus Sporothrix schenckii: Special focus on CYP51.
    Biochim Biophys Acta 2018 01 5;1866(1):166-177. Epub 2017 Oct 5.
    Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, Free State, South Africa. Electronic address:
    Sporotrichosis is an emerging chronic, granulomatous, subcutaneous, mycotic infection caused by Sporothrix species. Sporotrichosis is treated with the azole drug itraconazole as ketoconazole is ineffective. It is a well-known fact that azole drugs act by inhibiting cytochrome P450 monooxygenases (P450s), heme-thiolate proteins. Read More

    Clotrimazole is highly effective in vitro against feline Sporothrix brasiliensis isolates.
    J Med Microbiol 2017 Nov 6;66(11):1573-1580. Epub 2017 Oct 6.
    1​Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Purpose: Sporothrix brasiliensis, the most virulent species in the Sporothrix schenckii complex, is responsible for the ongoing epidemics of human and animal sporotrichosis in Brazil. Feline outbreaks are usually driven by S. brasiliensis and followed by extensive transmission to humans. Read More

    Differences in clinical ocular outcomes between exogenous and endogenous endophthalmitis caused by : a systematic review of published literature.
    Br J Ophthalmol 2017 Sep 28. Epub 2017 Sep 28.
    Medicine School, Universidad Nacional Mayor de San Marcos, Lima, Peru.
    Background: Sporotrichosis is an implantation mycosis caused by species prevalent worldwide, which occasionally can also result in intraocular infection presenting as an exogenous or endogenous infection (disseminated sporotrichosis). Knowledge in its clinical recognition and management is limited.

    Aims: To systematically review and analyse data from published literature with a view to comparing clinical outcomes between exogenous and endogenous endophthalmitis caused by . Read More

    Tacrolimus Increases the Effectiveness of Itraconazole and Fluconazole against spp.
    Front Microbiol 2017 15;8:1759. Epub 2017 Sep 15.
    Laboratório de Bioquímica Microbiana, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Goés, Universidade Federal do Rio de JaneiroRio de Janeiro, Brazil.
    Calcineurin inhibitors - such as the clinically used drug tacrolimus - are active against important fungal pathogens, particularly when combined with azoles. However, tacrolimus has not been tested against sporotrichosis, an endemic subcutaneous mycosis with worldwide distribution. Here, we evaluated the activity of tacrolimus and cyclosporine A - as monotherapy and in combination with itraconazole or fluconazole - against yeasts of and , the main sporotrichosis agents in Brazil. Read More

    Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex.
    Rev Soc Bras Med Trop 2017 Jul-Aug;50(4):554-557
    Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
    Introduction:: We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.

    Methods:: Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen. Read More

    The Gene Encoding for the Ribosomal Protein L6 Has Constitutive and Stable Expression and Works as an Endogenous Control in Gene Expression Analysis.
    Front Microbiol 2017 1;8:1676. Epub 2017 Sep 1.
    División de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de GuanajuatoGuanajuato, Mexico.
    is one of the causative agents of sporotrichosis, a worldwide-distributed mycosis that affects humans and other mammals. The interest in basic and clinical features of this organism has significantly increased in the last years, yet little progress in molecular aspects has been reported. Gene expression analysis is a set of powerful tools that helps to assess the cell response to changes in the extracellular environment, the genetic networks controlling metabolic pathways, and the adaptation to different growth conditions. Read More

    The Current Status of Feline Sporotrichosis in Malaysia.
    Med Mycol J 2017 ;58(3):E107-E113
    Former Han Veterinary Surgery.
    Feline sporotrichosis has been reported in Malaysia since the 1990's. Since then, studies have revealed that clinical clade D, Sporothrix schenckii sensu stricto, of a single clonal strain is the most common cause of this disease in Malaysia. The prevalence of a single clonal strain from a clinical clade was never before reported in Asia in a specific geographical niche. Read More

    Exploring virulence and immunogenicity in the emerging pathogen Sporothrix brasiliensis.
    PLoS Negl Trop Dis 2017 Aug 30;11(8):e0005903. Epub 2017 Aug 30.
    Department of Medicine, Discipline of Infectious Diseases, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
    Sporotrichosis is a polymorphic chronic infection of humans and animals classically acquired after traumatic inoculation with soil and plant material contaminated with Sporothrix spp. propagules. An alternative and successful route of transmission is bites and scratches from diseased cats, through which Sporothrix yeasts are inoculated into mammalian tissue. Read More

    Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar.
    J Mycol Med 2017 Sep 25;27(3):312-324. Epub 2017 Aug 25.
    Laboratoire de parasitologie-mycologie, CHU de Grenoble-Alpes, CS 10217, 38043 Grenoble cedex 9, France; Laboratoire TIMC-IMAG TheREx, université de Grenoble-Alpes, domaine de la Merci, 38706 La Tronche cedex, France. Electronic address:
    Chromoblastomycosis and sporotrichosis are endemic fungal infections of tropical and subtropical regions, including Madagascar. The causal fungi develop in the soil or on plants and infect humans through wounds, either directly (wounding by the plant, through thorns, for example), or through the contact of an existing wound with contaminated soil. For this reason, the lesions predominantly occur on the limbs, and these fungi principally infect people working outside with bare hands and/or feet. Read More

    Neglected endemic mycoses.
    Lancet Infect Dis 2017 Nov 31;17(11):e367-e377. Epub 2017 Jul 31.
    Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
    Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Read More

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