1,990 results match your criteria Sporotrichosis


Antifungal activity of diphenyl diselenide alone and in combination with itraconazole against Sporothrix brasiliensis.

Med Mycol 2018 Jun 19. Epub 2018 Jun 19.

Mycology Lab, Faculty of Medicine, Federal University of Rio Grande (FaMed-FURG), Rio Grande do Sul, Brazil.

Sporothrix brasiliensis is the main agent of feline and zoonotic sporotrichosis. Given the scarcity of options for sporotrichosis treatment and the promising activity of diphenyl diselenide (PhSe)2 against a diversity of fungal pathogens, this study aimed to evaluate the in vitro susceptibility of Sporothrix brasiliensis to (PhSe)2 alone and in combination with itraconazole (ITC). Forty clinical isolates of S. Read More

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Dacryocystitis due to sporothrix inoculated vis an unusual mode: Case report.

Medicine (Baltimore) 2018 Jun;97(25):e11182

Department of Pathology, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, P.R. China.

Rationale: Sporotrichosis is the most common subcutaneous mycosis. It is caused by the dimorphic fungus Sporothrix schenckii. Ocular sporotrichosis is uncommon and has been rarely reported. Read More

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Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia.

Genome Announc 2018 Jun 14;6(24). Epub 2018 Jun 14.

Cellular and Molecular Biology Unit, Corporación para Investigaciones Biológicas, Medellín, Colombia.

is a thermodimorphic fungal pathogen with a high genetic diversity. In this work, we present the assembly and similarity analysis of the whole-genome sequences of two clinical isolates from Colombia of . Read More

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Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis.

Sci Rep 2018 Jun 13;8(1):9074. Epub 2018 Jun 13.

Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Read More

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Proteins Potentially Involved in Immune Evasion Strategies in Elucidated by Ultra-High-Resolution Mass Spectrometry.

mSphere 2018 Jun 13;3(3). Epub 2018 Jun 13.

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

is the prevalent agent of a large zoonotic outbreak in Brazil. With the involvement of several thousands of cases, this is the largest cohort of human and animal sporotrichosis on record in the world. Infections are characterized by local cutaneous dissemination in humans without underlying disease. Read More

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Sporotrichosis: From KOH to Molecular Biology.

J Fungi (Basel) 2018 May 23;4(2). Epub 2018 May 23.

Histopathology Department, "Dr. Manuel Gea Gonzalez" General Hospital, Calz. de Tlalpan 4800, Belisario Domínguez Secc 16, Tlalpan, CDMX 14080, Mexico.

Sporotrichosis is a cosmopolitan, chronic granulomatous mycosis, acquired by traumatic inoculation and caused by . Several methods of diagnostic are available, from KOH to molecular biology. In this review, we describe from the simplest (clinical diagnosis) to the most advanced diagnostic techniques (molecular biology). Read More

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Repeated Exposition to Mercury (II) Chloride Enhances Susceptibility to Infection in Mice.

J Fungi (Basel) 2018 May 25;4(2). Epub 2018 May 25.

Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara-Jaú km 1, Araraquara 14800-903, Brazil.

Sporotrichosis is a subcutaneous mycosis that has re-emerged in several tropical and subtropical regions over the last decades. Growing findings suggest that the interplay of host, pathogen, and environment has a determinant effect on the diversity, local distribution, and virulence of , the etiologic agent. Among the environmental factors, we have studied the potential role of repeated exposures to mercury (Hg), a known immunotoxic xenobiotic that is widely used in gold mining regions where sporotrichosis outbreaks are frequently reported. Read More

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Nodular Lymphangitis (Sporotrichoid Lymphocutaneous Infections). Clues to Differential Diagnosis.

J Fungi (Basel) 2018 May 9;4(2). Epub 2018 May 9.

Dermatology Service & Mycology Department, Hospital General de Mexico, "Dr. Eduardo Liceaga", Balmis 148, Colonia Doctores, Ciudad de México 06726, Mexico.

Nodular lymphangitis, also known as sporotrichoid lymphocutaneous infections, is characterized by suppurative inflammatory nodules along the lymphatic vessels. This manifestation is classic of sporotrichosis, however, other infections such as nocardiosis, atypical mycobacteriosis, leishmaniasis, among others, can also express this clinical pattern. Sporotrichosis, which often occurs in gardeners, remains the most recognized cause of nodular lymphangitis. Read More

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Sporotrichin Skin Test for the Diagnosis of Sporotrichosis.

J Fungi (Basel) 2018 May 9;4(2). Epub 2018 May 9.

Dermatology Service & Mycology Department, Hospital General de México, "Dr. Eduardo Liceaga", Balmis 148, Colonia Doctores, Ciudad de México 06726, Mexico.

Sporotrichosis is the most common implantation mycosis caused by several species of the complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used for serological and skin testing. Read More

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Comparison of the Sensitivity of Three Methods for the Early Diagnosis of Sporotrichosis in Cats.

J Comp Pathol 2018 Apr 13;160:72-78. Epub 2018 Apr 13.

Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (Fiocruz), Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil.

Sporotrichosis is caused by species of fungi within the Sporothrix schenckii complex that infect man and animals. In Rio de Janeiro, Brazil, an epidemic has been observed since 1998, with most of the cases being related to transmission from infected cats. Although the definitive diagnosis of feline sporotrichosis is made by fungal culture, cytopathological and histopathological examinations are used routinely, because the long culture period may delay treatment onset. Read More

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Refractory feline sporotrichosis treated with itraconazole combined with potassium iodide.

J Small Anim Pract 2018 Apr 30. Epub 2018 Apr 30.

Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases/Oswaldo Cruz Foundation (Fiocruz), 21045-900 Rio de Janeiro, Brazil.

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Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women.

PLoS Negl Trop Dis 2018 04 23;12(4):e0006434. Epub 2018 Apr 23.

Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.

Background: Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Read More

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April 2018
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Image Gallery: Facial sporotrichosis.

Authors:
Y-K Xiang T Qu

Br J Dermatol 2018 Apr;178(4):e275

Department of Dermatology, Peking Union Medical College Hospital, Dongcheng District, Beijing, 100730, China.

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[Auricular sporotrichosis. Atypical case report simulating bacterial cellulitis].

Rev Chilena Infectol 2018;35(1):83-87

Departamento de Micología, Hospital General de México Dr. Eduardo Liceaga, México.

Sporotrichosis is the most common subcutaneous or implantation mycosis in Mexico. The case of a preauricular cutaneous-fixed sporotrichosis simulating atypical bacterial cellulitis is reported in an elderly patient with no history of trauma. The biopsy showed a suppurative granuloma with scarce yeast. Read More

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May 2018
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A Diabetic Elderly Man with Finger Ulcer.

Korean J Fam Med 2018 Mar 22;39(2):126-129. Epub 2018 Mar 22.

Dermatology Department, Hospital Raja Perempuan Zainab 2, Kelantan, Malaysia.

Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. Read More

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Fungal diseases in children and adolescents in a referral centre in Bogota, Colombia.

Mycoses 2018 Mar 30. Epub 2018 Mar 30.

Dermatology Resident, Fundación Universitaria Sanitas, Centro Dermatológico Federico Lleras Acosta, E.S.E., Bogotá, Colombia.

A cross-sectional descriptive study was conducted at a dermatology referral centre in Bogotá, to estimate the frequencies and aetiologies of mycoses in the population under 18 years of age attending the medical mycology laboratory over a 13-year period (2000-2012). A total of 1337 samples from 1221 patients were evaluated, involving direct examination and culture for 1279 samples, direct examination alone for 50 and culture alone for 8. During the study period, dermatophytosis was diagnosed via culture in 537 cases (40. Read More

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March 2018
3 Reads

The Infection Returns: A Case of Pulmonary Sporotrichosis Relapse after Chemotherapy.

Case Rep Med 2018 18;2018:1384029. Epub 2018 Feb 18.

Section of Pulmonary, Critical Care, and Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Background: Pulmonary sporotrichosis is a rare disease caused by a dimorphic fungus, . It is rarely found in association with malignancy. We present a case of pulmonary sporotrichosis recurrence after chemotherapy. Read More

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February 2018
1 Read

[Sporotrichosis in France].

Med Mal Infect 2018 Jun 16;48(4):298-300. Epub 2018 Mar 16.

Service de médecine interne et maladies infectieuses, Pr Bonnet-Bordeaux, CHU de Bordeaux, hôpital Saint-André, 1, rue burguet, 33000, Bordeaux, France. Electronic address:

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Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents.

Med Mycol 2018 Apr;56(suppl_1):126-143

Westerdijk Fungal Biodiversity Institute, Utrecht, and Center of Expertise in Mycology of Radboudumc/CWZ, Nijmegen, The Netherlands.

The description of cryptic species with different pathogenic potentials has changed the perspectives on sporotrichosis. Sporothrix schenckii causes a benign chronic subcutaneous mycosis, Sporothrix brasiliensis is highly virulent, and Sporothrix globosa mainly causes fixed cutaneous lesions. Furthermore, S. Read More

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April 2018
2 Reads

Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers.

PLoS Negl Trop Dis 2018 03 9;12(3):e0006169. Epub 2018 Mar 9.

MRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.

Sporotrichosis is a subcutaneous mycosis caused by pathogenic species of the Sporothrix genus. A new emerging species, Sporothrix brasiliensis, is related to cat-transmitted sporotrichosis and has severe clinical manifestations. The cell wall of pathogenic fungi is a unique structure and impacts directly on the host immune response. Read More

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March 2018
2 Reads

An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis.

Sci Rep 2018 Mar 8;8(1):4192. Epub 2018 Mar 8.

Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analysis, University of Sao Paulo, Sao Paulo, Brazil.

Sporothrix brasiliensis is the most virulent fungus of the Sporothrix complex and is the main species recovered in the sporotrichosis zoonotic hyperendemic area in Rio de Janeiro. A vaccine against S. brasiliensis could improve the current sporotrichosis situation. Read More

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Functional characterization of the Sporothrix schenckii Ktr4 and Ktr5, mannosyltransferases involved in the N-linked glycosylation pathway.

Res Microbiol 2018 Apr 21;169(3):188-197. Epub 2018 Feb 21.

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P. 36050, Guanajuato Gto., Mexico. Electronic address:

Sporothrix schenckii is one of the causative agents of the deep-seated mycosis sporotrichosis, a fungal infection with worldwide distribution. Fungus-specific molecules and biosynthetic pathways are potential targets for the development of new antifungal drugs. The MNT1/KRE2 gene family is a group of genes that encode fungus-specific Golgi-resident mannosyltransferases that participate in the synthesis of O-linked and N-linked glycans. Read More

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April 2018
2 Reads

Synthesis and Antifungal Activity of Coumarins Derivatives Against Sporothrix spp.

Curr Top Med Chem 2018 ;18(2):164-171

Departamento de Quimica Organica, Universidade Federal Fluminense, Instituto de Quimica, Niteroi, RJ, 24020-150, Brazil.

Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. Read More

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June 2018
3 Reads

Disseminated cutaneous sporotrichosis presenting as a necrotic facial mass: Case and review.

Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.

Department of Dermatology, University of California Davis Health System, Sacramento, California.

Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii, a group of common saprophytes of soil, plants, and organic debris. Disseminated forms may be seen in the setting of immunosuppression and are typically treated initially with intravenous lipidized amphotericin B. We report an unusual case of a 65-year-old woman who developed disseminated cutaneous sporotrichosis with extensive facial involvement in the absence of a known primary inoculation. Read More

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Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis.

Sci Rep 2018 Feb 13;8(1):2898. Epub 2018 Feb 13.

Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil.

The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. Read More

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February 2018

Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area.

Mem Inst Oswaldo Cruz 2018 Mar;113(3):185-196

Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Rio de Janeiro, RJ, Brasil.

Background: Sporotrichosis is caused by species of the genus Sporothrix. From 1998 to 2015, 4,703 cats were diagnosed at the Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Even after the description of the Sporothrix species, the characterisation of feline isolates is not performed routinely. Read More

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March 2018
2 Reads

A population genetics analysis in clinical isolates of Sporothrix schenckii based on calmodulin and calcium/calmodulin-dependent kinase partial gene sequences.

Mycoses 2018 Jun 23;61(6):383-392. Epub 2018 Mar 23.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.

Sporotrichosis is a subcutaneous mycosis that is caused by diverse species of Sporothrix. High levels of genetic diversity in Sporothrix isolates have been reported, but few population genetics analyses have been documented. To analyse the genetic variability and population genetics relations of Sporothrix schenckii Mexican clinical isolates and to compare them with other reported isolates. Read More

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June 2018
4 Reads

Sporotrichosis in the nail-An unusual location and presentation.

JAAD Case Rep 2018 Jan 19;4(1):47-49. Epub 2017 Dec 19.

Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina.

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January 2018

Epidemiology of fungal infections in China.

Front Med 2018 Feb 11;12(1):58-75. Epub 2018 Jan 11.

Shanghai Key Laboratory of Molecular Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.

With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. Read More

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February 2018
5 Reads

Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.

J Fungi (Basel) 2017 Feb 10;3(1). Epub 2017 Feb 10.

Dermatology Service, Mycology Department, Hospital General de México "Eduardo Liceaga", Balmis 148, Colonia Doctores, CP: 03020. Cd. de México, México.

Sporotrichosis is an implantation or inoculation mycosis caused by species of complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are () and . Read More

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February 2017

Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations.

BMC Vet Res 2018 Jan 18;14(1):19. Epub 2018 Jan 18.

Medical and Molecular Mycology Laboratory, Microbiology and Parasitology Department, Biomedical Institute, Fluminense Federal University (UFF), Rua Prof. Hernani Melo, 101 São Domingos, Niterói, RJ, CEP: 24210-130, Brazil.

Background: Sporotrichosis is a neglected zoonosis caused by pathogenic fungi belonging to the Sporothrix schenckii complex. In Rio de Janeiro state, this disease reached an epidemic status with over 4700 domestic felines and around 4000 humans affected since the mid-90s. The present study evaluated clinical and epidemiological aspects and also the frequency of colonization and infection by these fungi in healthy cats and among those with suspicious cutaneous lesions, inhabiting four Rio de Janeiro state distinct areas. Read More

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January 2018
3 Reads

Disseminated cutaneous sporotrichosis in patient with alcoholism.

Rev Soc Bras Med Trop 2017 Nov-Dec;50(6):871-873

Departamento de Dermatologia, Hospital Universitário de Santa Maria, Santa Maria, RS, Brasil.

Sporotrichosis is the most prevalent subcutaneous mycosis and is characterized by a subacute or chronic development of a cutaneous or subcutaneous nodular lesion. It is caused by the dimorphic fungus Sporothrix spp, which may manifest in different clinical forms. The disseminated cutaneous form is uncommon and is more likely to occur in immunocompromised patients. Read More

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April 2018
3 Reads

Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum.

JAAD Case Rep 2017 Nov 6;3(6):519-521. Epub 2017 Nov 6.

Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan.

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November 2017
3 Reads

Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas.

Am J Ophthalmol Case Rep 2017 Dec 23;8:35-38. Epub 2017 Sep 23.

Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.

Purpose: Sporotrichosis is a subcutaneous mycosis caused by sp., a dimorphic fungus. Although the cutaneous form is the most frequent form, the ocular presentation has been increasingly diagnosed in epidemic areas. Read More

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December 2017
2 Reads

Successful Treatment of Canine Sporotrichosis with Terbinafine: Case Reports and Literature Review.

Mycopathologia 2018 Apr 8;183(2):471-478. Epub 2017 Dec 8.

Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.

Sporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. Read More

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April 2018
3 Reads

Proteases of Sporothrix schenckii: Cytopathological effects on a host-cell model.

Rev Iberoam Micol 2018 Jan - Mar;35(1):32-38. Epub 2017 Dec 6.

Laboratorio de Micología Básica, Unidad de Medicina Experimental, Facultad de Medicina, UNAM, Dr. Balmis No. 148, Col. Doctores, Del. Cuauhtémoc, Mexico, DF, Mexico.

Background: Sporotrichosis is a fungal infection caused by the Sporothrix schenckii complex. The adhesion of the fungus to the host tissue has been considered the key step in the colonization and invasion, but little is known about the early events in the host-parasite interaction.

Aims: To evaluate the proteolytic activity of S. Read More

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December 2017
2 Reads

Successful treatment outcome with itraconazole and potassium iodide in disseminated sporotrichosis.

Indian J Dermatol Venereol Leprol 2018 Jan-Feb;84(1):101-104

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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December 2017
4 Reads

Lymphocutaneous Sporotrichosis Treated with Potassium Iodide with Development of Subclinical Hypothyroidism: Wolff-Chaikoff Effect?

Indian Dermatol Online J 2017 Nov-Dec;8(6):475-477

Department of Dermatology, Dr Ram Manohar Lohia Hospital, New Delhi, India.

Sporotrichosis is a subcutaneous mycotic infection caused by that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. Read More

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December 2017
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Sporotrichosis by senso stricto with itraconazole resistance and terbinafine sensitivity observed and : Case report.

Med Mycol Case Rep 2018 Mar 28;19:18-20. Epub 2017 Oct 28.

Postgraduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, Brazil.

We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. Read More

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March 2018
5 Reads

Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics.

An Bras Dermatol 2017 Sep-Oct;92(5):606-620

Dermatology Department, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro (FCM-UERJ), Rio de Janeiro, RJ, Brazil.

In the late 90's there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. Read More

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February 2018

AIDS-Related Endemic Mycoses in Western Cape, South Africa, and Clinical Mimics: A Cross-Sectional Study of Adults With Advanced HIV and Recent-Onset, Widespread Skin Lesions.

Open Forum Infect Dis 2017 25;4(4):ofx186. Epub 2017 Aug 25.

Division of Infectious Diseases and HIV Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, Western Cape, South Africa.

Background: Skin lesions are common in advanced HIV infection and are sometimes caused by serious diseases like systemic mycoses (SM). AIDS-related SM endemic to Western Cape, South Africa, include emergomycosis (formerly disseminated emmonsiosis), histoplasmosis, and sporotrichosis. We previously reported that 95% of patients with AIDS-related emergomycosis had skin lesions, although these were frequently overlooked or misdiagnosed clinically. Read More

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August 2017
4 Reads

Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count.

Case Rep Infect Dis 2017 25;2017:4713140. Epub 2017 Sep 25.

Hospital Universitário Gaffrée e Guinle, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Tijuca, 20270-004 Rio de Janeiro, RJ, Brazil.

Sporotrichosis is a human and animal disease caused by species of the complex. It is classically acquired through traumatic inoculation of fungal elements. Most frequently, sporotrichosis presents as a fixed cutaneous or as a lymphocutaneous form. Read More

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September 2017
6 Reads

Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model.

Med Mycol 2017 Oct 26. Epub 2017 Oct 26.

School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, SP, Brazil.

This report describes a model of host resistance for Sporothrix schenckii, an opportunistic fungi in immunosuppressed mice with cyclophosphamide (CY) to be used in studies of immunotoxicology and immunopharmacology. Two doses of CY were administered intraperitoneally: 200 mg/kg and a booster of 150 mg/kg at 9-day intervals. Three days after the first dose of CY the animals were infected subcutaneously with 1. Read More

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October 2017
2 Reads

Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus).

J Eur Acad Dermatol Venereol 2018 Apr 22;32(4):e157-e158. Epub 2017 Nov 22.

Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - RJ, 21040-360, Brazil.

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April 2018
1 Read

Cavitary Pulmonary Sporotrichosis: Case Report and Literature Review.

Mycopathologia 2017 Dec 23;182(11-12):1119-1123. Epub 2017 Oct 23.

Departamento de Micología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, CONICET, Resistencia, Argentina.

A case of cavitary pulmonary sporotrichosis without mucocutaneous involvement caused by Sporothrix schenckii is reported in a sexagenarian woman with a long smoking history. The patient was hospitalized for septic shock with multiorgan failure from a respiratory focus. The diagnosis was delayed due to the fungal etiological agent was not initially considered in the differential diagnosis. Read More

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December 2017
3 Reads

Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis.

Case Rep Dermatol 2017 May-Aug;9(2):119-129. Epub 2017 Aug 17.

Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. Read More

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August 2017
6 Reads

An unusual cutaneous infection caused by .

JMM Case Rep 2017 Apr 12;4(4):e005088. Epub 2017 Apr 12.

Department of Health Science, University of Eastern Piedmont, Novara, Italy.

is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis. Read More

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April 2017
3 Reads

Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China.

Emerg Microbes Infect 2017 Oct 11;6(10):e88. Epub 2017 Oct 11.

Department of Dermatology and Venereology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.

Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. Read More

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October 2017
2 Reads