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    1 OF 38

    The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.
    Immunology 2017 Jan 31. Epub 2017 Jan 31.
    Department of Clinical Analysis, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University (FCF/UNESP), Araraquara, SP, Brazil.
    Sporotrichosis is a mycosis caused by fungi from the Sporothrix schenckii species complex, whose prototypical member is Sporothrix schenckii sensu stricto. Pattern recognition receptors (PRRs) recognize and respond to pathogen-associated molecular patterns (PAMPs) and shape the following adaptive immune response. A family of PRRs most frequently associated with fungal recognition is the nucleotide-binding oligomerization domain-like receptor (NLR). Read More

    Comparison of two in vitro antifungal sensitivity tests and monitoring during therapy of Sporothrix schenckii sensu stricto in Malaysian cats.
    Vet Dermatol 2017 Feb;28(1):156-e32
    Servizi Dermatologici Veterinari, Strada Bedale della Ressia 2, 12016, Peveragno (CN), Italy.
    Background: Feline sporotrichosis is common in Malaysia. Thermosensitivity and effects of azole treatment on fungal susceptibility are unknown.

    Objectives: To evaluate thermotolerance and antifungal susceptibility of feline Malaysian Sporothrix isolates, compare microdilution (MD) and E-test results, and investigate changes in susceptibility during azole therapy. Read More

    Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission.
    PLoS Pathog 2017 Jan 19;13(1):e1006077. Epub 2017 Jan 19.
    Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil.

    The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host.
    Neurohospitalist 2017 Jan 5;7(1):30-34. Epub 2016 Apr 5.
    Department of Neurology, University of California, San Francisco, CA, USA; Infectious Diseases, Department of Medicine, University of California, San Francisco, CA, USA.
    Chronic meningitis of unknown etiology is a vexing illness for patients and clinicians. Identification of the correct pathogen can be challenging and time consuming, leading to delays in appropriate treatment. Although Sporothrix schenckii is a recognized and treatable cause of chronic meningitis, neurologists and infectious diseases physicians may not regularly evaluate for Sporothrix infection. Read More

    Sporothrix schenckii Sensu Lato identification in fragments of skin lesion cultured in NNN medium for differential diagnosis of cutaneous leishmaniasis.
    Diagn Microbiol Infect Dis 2017 Feb 15;87(2):118-120. Epub 2016 Nov 15.
    Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Fellow researcher of Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil; Fellow researcher ("Cientista do Nosso Estado") of Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Brazil.
    Eighty-nine patients with clinical suspicion of leishmaniasis were referred for differential diagnosis. Sporothrix schenckii sensu lato was isolated in Novy-MacNeal-Nicolle + Schneider media in 98% of 64 patients with final diagnosis of sporotrichosis. This medium may be suitable for diagnosis of sporotrichosis in areas where cutaneous leishmaniasis is also endemic. Read More

    [Presence of lactoferrin (LF) in lymphocutaneous sporotrichosis. Yeast-bound antimicrobial peptide].
    Gac Med Mex 2016 Nov - Dec;152(6):831-835
    Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, Ciudad de México, México.
    Sporotrichosis is a common subcutaneous mycosis in Latin America, produced by dimorphic fungi belong to Sporothrix schenckii complex of cryptic species. Infection is acquired by traumatic inoculation with contaminated organic material. Host immune response includes polymorphonuclear neutrophils chemotaxis and release of granular components. Read More

    Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii.
    J Ethnopharmacol 2017 Jan 14;195:266-274. Epub 2016 Nov 14.
    Faculdade de Ciências Farmacêuticas. Universidade Estadual Paulista Julio Mesquita Filho, UNESP, Rod. Araraquara-Jaú - Km 1 -s/n -CEP: 14800-903, Araraquara, SP, Brazil.
    Ethnopharmacological Relevance: Vismia guianensis (Aubl.) Pers. is traditionally used in North and Northeast of Brazil for the treatment of dermatomycoses. Read More

    Efficacy and safety of itraconazole use in infants.
    World J Pediatr 2016 Nov 10;12(4):399-407. Epub 2016 Jun 10.
    Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, 610041, China.
    Background: Itraconazole has been used to treat fungal infections, in particular invasive fungal infections in infants or neonates in many countries.

    Data Sources: Literature search was conducted through Ovid EMBASE, PubMed, ISI Web of Science, CNKI and Google scholarship using the following key words: "pediatric" or "infant" or "neonate" and "fungal infection" in combination with "itraconazole". Based on the literature and our clinical experience, we outline the administration of itraconazole in infants in order to develop evidence-based pharmacotherapy. Read More

    Refractory sporotrichosis due to Sporothrix brasiliensis in humans appears to be unrelated to in vivo resistance.
    Med Mycol 2016 Oct 22. Epub 2016 Oct 22.
    Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
    Sporotrichosis is a subacute to chronic infection caused by members of the Sporothrix schenckii complex. Itraconazole is the first choice antifungal drug for treating this infection, with terbinafine and potassium iodide as alternatives and amphotericin B used in cases of severe infections. Correlation of antifungal susceptibility data with the clinical outcome of the patients is scarce. Read More

    Invasive Fungal Disease in Renal Transplant Recipients at a Brazilian Center: Local Epidemiology Matters.
    Transplant Proc 2016 Sep;48(7):2306-2309
    Infectious Disease Clinic, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
    Introduction: Invasive fungal disease (IFD) is an important complication after solid organ transplantation (SOT). A marked geographic variation in the epidemiology of IFD after kidney transplantation (KT) has been suggested by the results of previous studies. Nevertheless, data from Latin American centers are scarce. Read More

    Tinea on a Tattoo.
    Acta Dermatovenerol Croat 2016 Aug;24(3):223-4
    Marius Irimie, MD, 40, Zizinului Street, Bl. 31, Sc. C, Ap. 2, 500414, Brasov, Romania;
    In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19). Read More

    Antifungal and immunomodulatory activity of a novel cochleate for amphotericin B delivery against Sporothrix schenckii.
    Int Immunopharmacol 2016 Nov 16;40:277-287. Epub 2016 Sep 16.
    Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, Universidade Estadual Paulista Julio Mesquita Filho, UNESP, Rodovia Araraquara-Jaú - Km 1, CEP: 14801-902, Araraquara, São Paulo, Brazil. Electronic address:
    Introduction: Sporotrichosis is an emergent subcutaneous mycoses caused by species of the Sporothrix schenckii complex. Amphotericin B (AmB) remains the main antifungal drug for the treatment of systemic infections, but its use is limited by toxicity reasons. AFCo3 is a novel cochleate containing detoxified LPS, which exhibits drug delivery and immunomodulating properties. Read More

    Whole-Genome Sequencing and In Silico Analysis of Two Strains of Sporothrix globosa.
    Genome Biol Evol 2016 Dec 14;8(11):3292-3296. Epub 2016 Dec 14.
    IRCCS Centro Neurolesi "Bonino-Pulejo", SS113, Messina, Italy
    Sporothrix globosa is a thermo-dimorphic fungus belonging to a pathogenic clade that also includes Sporothrix schenckii, which causes human and animal sporotrichosis. Here, we present the first genome assemblies of two S. globosa strains providing data for future comparative genomic studies in pathogenic Sporothrix species. Read More

    Is There Any Difference between the In Situ and Systemic IL-10 and IFN-γ Production when Clinical Forms of Cutaneous Sporotrichosis Are Compared?
    PLoS One 2016 13;11(9):e0162764. Epub 2016 Sep 13.
    Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, RJ, Brazil.
    Fungus of the Sporothrix schenckii complex can produce skin lesions in humans, commonly lymphocutaneous (LC) and fixed (F) forms of sporotrichosis. Some authors have suggested that clinical forms are influenced by differences in virulence and genetic profile of isolates. But little is known about the role of immune response in determining the clinical outcome of sporotrichosis. Read More

    The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship.
    Stud Mycol 2016 27;83:165-91. Epub 2016 Jul 27.
    Department of Microbiology and Plant Pathology, Forestry and Agricultural Research Institute (FABI), University of Pretoria, Pretoria 0002, South Africa.
    One of the causal agents of human sporotrichosis, Sporothrix schenckii, is the type species of the genus Sporothrix. During the course of the last century the asexual morphs of many Ophiostoma spp. have also been treated in Sporothrix. Read More

    Mortality From Fungal Diseases in the US Air Force From 1970 to 2013.
    US Army Med Dep J 2016 Oct-Dec(3-16):38-41
    New York State Department of Health, Albany, New York.
    We review a unique set of documents, death certificates, catalogued in the US Air Force Mortality Registry, which tracks deaths for current and retired Air Force service members. We screened the records for all deaths caused by fungal diseases between 1970 and 2013. There were 216 deaths caused by a variety of diseases such as aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, pneumocystosis, sporotrichosis, and zygomycosis. Read More

    Osteomyelitis caused by Sporothrix schenckii in an immunocompetent patient.
    Rev Soc Bras Med Trop 2016 Jul-Aug;49(4):527-9
    Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
    Sporotrichosis is the most common subcutaneous mycosis in South America and its association with zoonotic transmission remains a relevant public health problem in Rio de Janeiro, Brazil. The disease most commonly presents as subacute or chronic cutaneous lesions, although dissemination to various organs and systems occurs in rare cases, mainly in immunosuppressed individuals. This report describes a case of sporotrichosis with severe bone and subcutaneous damage in an immunocompetent patient who did not exhibit the characteristic skin lesions of sporotrichosis, including ulcers, nodules, and lymphangitis. Read More

    [Epidemiological clinical and laboratory characterization of sporotrichosis in patients of a tertiary care hospital in Lima, Peru, from 1991 to 2014].
    Rev Chilena Infectol 2016 Jun;33(3):315-21
    Hospital Cayetano Heredia, Perú
    Background: Sporothricosis is endemic in numerous Latin American countries and the rest of the world. In Peru is concentrated in regions with warm and humid climate being little known in the rest of the country.

    Aim: To describe the epidemiological, clinical and laboratory characteristics of patients diagnosed of sporotrichosis in a tertiary-care level hospital in Lima, Peru from 1991 to 2014. Read More

    Disseminated sporotrichosis in an immunocompetent patient.
    Case Reports Plast Surg Hand Surg 2016 31;3(1):44-7. Epub 2016 May 31.
    Division of Infectious Diseases, Department of Medicine , Tucson , AZ , USA.
    Sporothrix schenckii, the causative agent of sporotrichosis, is a relatively rare infection. Local infection usually occurs through direct inoculation of the organism through the skin; disseminated disease is rarely seen. This article describes a case of disseminated sporotrichosis in a middle-aged man without the commonly seen risk factors for dissemination. Read More

    Studies in Phylogeny, Development of Rapid IdentificationMethods, Antifungal Susceptibility, and Growth Rates of Clinical Strains of Sporothrix schenckii Complex in Japan.
    Med Mycol J 2016 ;57(3):E47-57
    Medical Mycology Research Center, Chiba University.
    Sporotrichosis is a fungal infection caused by the Sporothrix species, which have distinct virulence profiles and geographic distributions. We performed a phylogenetic study in strains morphologically identified as Sporothrix schenckii from clinical specimens in Japan, which were preserved at the Medical Mycology Research Center, Chiba University. In addition, we examined the in vitro antifungal susceptibility and growth rate to evaluate their physiological features. Read More

    Adamantylidene-substituted alkylphosphocholine TCAN26 is more active against Sporothrix schenckii than miltefosine.
    Mem Inst Oswaldo Cruz 2016 Aug 11;111(8):523-7. Epub 2016 Jul 11.
    Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Instituto de Biofísica Carlos Chagas Filho, Laboratório de Biologia Celular de Fungos, Rio de Janeiro, RJ, Brasil.
    Sporotrichosis is the most frequent subcutaneous mycosis in the world and its increasing incidence has led to the search for new therapeutic options for its treatment. In this study, we demonstrated that three structural analogues of miltefosine (TCAN26, TC19, and TC70) showed inhibitory activity against Sporothrix schenckii sensu stricto and that TCAN26 was more active in vitro than miltefosine against several isolates. Scanning electron microscopy showed that S. Read More

    Disseminated cutaneous sporotrichosis associated with ocular lesion in an immunocompetent patient.
    An Bras Dermatol 2016 Jul-Aug;91(4):537-9
    Universidade Federal do Espírito Santo (UFES) - Vitória (ES), Brazil.
    A 59-year-old female patient, previously healthy, immunocompetent, presented left bulbar conjunctiva lesions and nodular-ulcerated lesions on the arms and cervical region, besides left cervical and retroauricular lymphadenopathy. She had previous contact with domestic cats that excoriated her face. The diagnosis was conclusive of disseminated sporotrichosis through clinical and epidemiological history and cultures of skin and ocular secretions. Read More

    [Virulence of Sporothrix globosa in murine models].
    Rev Argent Microbiol 2016 Jul - Sep;48(3):196-199. Epub 2016 Aug 25.
    Anatomía Patológica, Universidad de Valparaíso, Chile.
    Introduction: The sporothricosis disease is an infection caused by species included in Sporothrix schenkii complex.

    Objective: Verify the virulence of a strain of S. globosa using two different concentrations of inoculum by intraperitoneally and subcutaneously, into a mouse model. Read More

    In Vitro Susceptibility of Sporothrix brasiliensis to Essential Oils of Lamiaceae Family.
    Mycopathologia 2016 Dec 16;181(11-12):857-863. Epub 2016 Aug 16.
    Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
    This study evaluated the chemical, cytotoxic and anti-Sporothrix brasiliensis properties of commercial essential oils of rosemary (Rosmarinus officinalis L.), oregano (Origanum vulgare L.) and marjoram (Origanum majorana L. Read More

    Clinical features of 10 cases of eyelid sporotrichosis in Jilin Province (Northeast China).
    Can J Ophthalmol 2016 Aug 10;51(4):297-301. Epub 2016 May 10.
    Department of Ophthalmology, Second Hospital of JiLin University, ChangChun, China. Electronic address:
    Objective: Sporotrichosis is a common subcutaneous mycosis caused by an infection with dimorphic fungus Sporothrix schenckii. We present a series of patients with eyelid sporotrichosis and study the clinical and histopathological presentation, microbiology, treatment options, and outcome.

    Methods: A retrospective case-series study of patients with a clinical diagnosis of eyelid sporotrichosis. Read More

    Cytotoxicity and anti-Sporothrix brasiliensis activity of the Origanum majorana Linn. oil.
    Braz J Microbiol 2016 Oct - Dec;47(4):896-901. Epub 2016 Jul 29.
    Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, Departamento de Farmacologia, Porto Alegre, RS, Brazil.
    The study aimed to evaluate the anti-Sporothrix sp. activity of the essential oil of Origanum majorana Linn. (marjoram), its chemical analysis, and its cytotoxic activity. Read More

    Cutaneous Involvement in the Deep Mycoses: A Literature Review. Part I-Subcutaneous Mycoses.
    Actas Dermosifiliogr 2016 Dec 30;107(10):806-815. Epub 2016 Jun 30.
    Departamento de Dermatología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
    The deep mycoses are uncommon in our setting. These fungal infections occur mainly in immunosuppressed patients or in tropical climates, and include subcutaneous infections and systemic infections. The skin is always involved in the former. Read More

    Chromoblastomycosis due to Fonsecaea monophora misdiagnosed as sporotrichosis and cutaneous tuberculosis in a pulmonary tuberculosis patient.
    Med Mycol Case Rep 2016 Mar 10;11:57-60. Epub 2016 May 10.
    Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, PR China.
    Chromoblastomycosis is caused by dematiaceous fungi. It develops after inoculation of the organism into the skin. We report a case of chromoblastomycosis in a pulmonary tuberculosis patient without known history of trauma. Read More

    Cholinergic enzymes and inflammatory markers in rats infected by Sporothrix schenckii.
    Microb Pathog 2016 Aug 1;97:94-102. Epub 2016 Jun 1.
    Department of Small Animals, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:
    The aim of this study was to evaluate the cholinesterase activity in serum, whole blood, and lymphocytes, as well as to verify its relation to immune response in rats experimentally infected by Sporothrix schenckii. For this study, 63 Wistar rats (Rattus norvegicus), male, adult were divided into three groups: the negative control group (GC: n = 21), the group infected subcutaneously (GSC: n = 21), and the group infected intraperitoneally (GIP: n = 21). The groups were divided into subgroups and the following variables were evaluated at 15, 30, and 40 days post-infection (PI): acetylcholinesterase (AChE) activity in lymphocytes and whole blood, butyrylcholinesterase (BChE) activity in serum, cytokines levels (IL-1, IL-6, TNFα, and INF-γ), immunoglobulins levels (IgA, IgG, IgM, and IgE), and protein profile by electrophoresis. Read More

    Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study.
    Med Mycol 2016 Oct 20;54(7):684-90. Epub 2016 May 20.
    Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals (Lapclin-Dermzoo), Evandro Chagas National Institute of Infectious Diseases (INI)/Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
    Feline sporotrichosis is an endemic disease in Rio de Janeiro, Brazil, where zoonotic transmission of Sporothrix spp. has been reported since 1998. Itraconazole (ITZ) remains the first choice for treating this disease in cats. Read More

    Lower percentage of CD8+ T cells in peripheral blood of patients with sporotrichosis.
    Hum Immunol 2016 Jul 12;77(7):576-9. Epub 2016 May 12.
    Department of Dermatology, China-Japan Union Hospital Of Jilin University, 126 Xiantai St, Erdao, Changchun, Jilin 130033, China. Electronic address:
    Purpose: To characterize the peripheral immunity and immunity response of patients with sporotrichosis, in this study we determined the lymphocyte subsets in the peripheral blood of Chinese patients with sporotrichosis.

    Methods: In this retrospective study, peripheral blood was collected from 69 sporotrichosis patients (37, fixed cutaneous form; 32 lymphocutaneous) and 66 healthy controls. Lymphocyte subsets were analyzed using flow cytometry. Read More

    Sporotrichosis as an unusual case of osteomyelitis: A case report and review of the literature.
    Med Mycol Case Rep 2016 Mar 7;11:31-5. Epub 2016 Apr 7.
    Scripps Mercy Hospital, San Diego, CA, United States; Naval Medical Center San Diego, San Diego, CA, United States.
    Sporotrichosis is an infection of worldwide distribution caused by the dimorphic fungus, Sporothrix schenckii. Acquisition typically occurs via cutaneous inoculation with development of a localized cutaneous and/or lymphocutaneous infection. We present a rare case of osteoarticular sporotrichosis in a 39-year-old man and review the literature noting only 20 published cases since 1980. Read More

    Sporotrichosis of Maxillary Sinuses in a Middle Aged Female Patient from Rural Area of Eastern India.
    J Clin Diagn Res 2016 Mar 1;10(3):DD01-2. Epub 2016 Mar 1.
    Postgraduate Trainee, Department of Microbiology, Medical College , Kolkata, India .
    Sporotrichosis is commonly a chronic infection caused by Sporothrix schenckii, a saprophytic fungus and is usually limited to cutaneous and subcutaneous tissues. Disseminated systemic, osteoarticular or pulmonary sporotrichosis have been reported but nasal sinusitis by this fungus is extremely infrequent. Earlier report from southern India documented a case of maxillary sinusitis by Sporothrix schenckii. Read More

    Molecular Components of the Sporothrix schenckii Complex that Induce Immune Response.
    Curr Microbiol 2016 Aug 27;73(2):292-300. Epub 2016 Apr 27.
    Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Av. Veterinaria S/N, 34120, Durango, Dgo., Mexico.
    Sporotrichosis is a fungal disease caused by the Sporothrix schenckii complex that includes species such as S. brasiliensis, S. schenckii sensu stricto, S. Read More

    Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole.
    Am J Trop Med Hyg 2016 Jun 25;94(6):1218-22. Epub 2016 Apr 25.
    Cell Biology Division, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, Brazil; Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil.
    Sporotrichosis is a polymorphic disease of humans and animals, which is acquired via traumatic inoculation of Sporothrix propagules into cutaneous or subcutaneous tissue. The etiological agents are in a clinical complex, which includes Sporothrix brasiliensis, Sporothrix schenckii, Sporothrix globosa, and Sporothrix luriei, each of which has specific epidemiological and virulence characteristics. Classical manifestation in humans includes a fixed localized lesion at the site of trauma plus lymphocutaneous sporotrichosis with fungal spreading along the lymphatic channels. Read More

    Atypical Cutaneous Sporotrichosis in an Immunocompetent Adult: Response to Potassium Iodide.
    Indian J Dermatol 2016 Mar-Apr;61(2):236
    Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
    Cutaneous sporotrichosis, also known as "Rose Gardener's disease," caused by dimorphic fungus Sporothrix schenkii, is usually characterized by indolent nodular or nodulo-ulcerative lesions arranged in a linear pattern. We report bizarre nonlinear presentation of Sporotrichosis, in an immunocompetent adult occurring after a visit to Amazon rain forest, speculating infection with more virulent species of Sporothrix. The diagnosis was reached with the help of periodic acid-Schiff positive yeast cells and cigar shaped bodies seen in skin biopsy along with the therapeutic response to potassium iodide. Read More

    Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis.
    J Immunol Res 2016 14;2016:6525831. Epub 2016 Mar 14.
    Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Avenida Veterinaria S/N, 34120 Durango, DGO, Mexico.
    Cell wall (CW) components of fungus Sporothrix schenckii are the major inductors antigens of immune responses. The immunodominant 60 kDa glycoprotein (gp60) has been shown to be associated with the virulence of this fungus but its role in experimental sporotrichosis is unknown. In this work, the immunological effects of CW-purified gp60 were investigated in a model of experimental subcutaneous sporotrichosis in normal and gp60-preimmunized C57BL/6 and BALB/c mice strains which were then infected with S. Read More

    Draft Genome Sequence of the Dimorphic Fungus Sporothrix pallida, a Nonpathogenic Species Belonging to Sporothrix, a Genus Containing Agents of Human and Feline Sporotrichosis.
    Genome Announc 2016 Mar 31;4(2). Epub 2016 Mar 31.
    Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy IRCCS Centro Neurolesi "Bonino-Pulejo," Messina, Italy
    Sporothrix pallidais considered to be a mostly avirulent environmental fungus, phylogenetically closely related to the well-known pathogenSporothrix schenckii Here, we present the first assembly of its genome, which provides a valuable resource for future comparative genomic studies between nonpathogenic and pathogenicSporothrixspp. Read More

    Melanins Protect Sporothrix brasiliensis and Sporothrix schenckii from the Antifungal Effects of Terbinafine.
    PLoS One 2016 31;11(3):e0152796. Epub 2016 Mar 31.
    Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
    Terbinafine is a recommended therapeutic alternative for patients with sporotrichosis who cannot use itraconazole due to drug interactions or side effects. Melanins are involved in resistance to antifungal drugs and Sporothrix species produce three different types of melanin. Therefore, in this study we evaluated whether Sporothrix melanins impact the efficacy of antifungal drugs. Read More

    Δ(24)-Sterol Methyltransferase Plays an Important Role in the Growth and Development of Sporothrix schenckii and Sporothrix brasiliensis.
    Front Microbiol 2016 11;7:311. Epub 2016 Mar 11.
    Laboratório de Biologia Celular de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.
    Inhibition of Δ(24)-sterol methyltransferase (24-SMT) in Sporothrix schenckii sensu stricto and Sporothrix brasiliensis was investigated in vitro. The effects on fungal growth and sterol composition of the 24-SMT inhibitor 22-hydrazone-imidazolin-2-yl-chol-5-ene-3β-ol (H3) were compared to those of itraconazole. MIC and MFC analysis showed that H3 was more effective than itraconazole against both species in both their filamentous and yeast forms. Read More

    Antifungal curcumin promotes chitin accumulation associated with decreased virulence of Sporothrix schenckii.
    Int Immunopharmacol 2016 May 17;34:263-70. Epub 2016 Mar 17.
    Department of Dermatology and Venereology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:
    Curcumin, a yellow polyphenol compound, is known to possess antifungal activity for a range of pathogenic fungi. However, the fungicidal mechanism of curcumin (CUR) has not been identified. We have occasionally found that chitin redistributes to the cell wall outer layer of Sporothrix schenckii (S. Read More

    MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHOSIS IN PATIENTS WITH HIV/AIDS.
    Retin Cases Brief Rep 2017 Winter;11(1):67-70
    *Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; †Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; ‡Centro Hospitalar do Instituto Nacional de Infectologia, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; and §Laboratório de Micologia, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
    Purpose: In this article, the authors describe multifocal choroiditis related to disseminated sporotrichosis in patients with HIV/AIDS.

    Methods: We conducted a retrospective observational study of three patients infected with HIV who presented with disseminated sporotrichosis characterized by cutaneous lesions, multifocal choroiditis, and other manifestations, including osteomyelitis and involvement of the bone marrow, larynx, pharynx, and nasal and oral mucosa.

    Results: Five eyes of three patients with HIV/AIDS showed multifocal choroiditis related to disseminated sporotrichosis. Read More

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