2,181 results match your criteria Sporotrichosis


Canine sporotrichosis: polyphasic taxonomy and antifungal susceptibility profiles of Sporothrix species in an endemic area in Brazil.

Braz J Microbiol 2020 Jul 2. Epub 2020 Jul 2.

Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Sporotrichosis, a mycosis caused by pathogenic species of the genus Sporothrix, affects diverse species of mammals. Until 2007, Sporothrix schenckii was considered the unique etiologic agent of sporotrichosis. Canine sporotrichosis is a poorly reported disease, and the majority of cases are from Rio de Janeiro, Brazil. Read More

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http://dx.doi.org/10.1007/s42770-020-00328-8DOI Listing

Genome-wide mapping using new AFLP markers to explore intraspecific variation among pathogenic Sporothrix species.

PLoS Negl Trop Dis 2020 Jul 1;14(7):e0008330. Epub 2020 Jul 1.

Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

Sporotrichosis is a chronic subcutaneous mycosis caused by Sporothrix species, of which the main aetiological agents are S. brasiliensis, S. schenckii, and S. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008330DOI Listing

Fungal Infections of the Hand.

Hand Clin 2020 Aug;36(3):355-360

Department of Orthopaedic Surgery, Philadelphia Hand to Shoulder Center, Thomas Jefferson University, 834 Chestnut Street, Suite G-114, Philadelphia, PA 19107, USA.

Clinically significant fungal infections of the upper extremity are uncommon but increasing They are classified based on anatomic location and epidemiology. The anatomic categories that affect the hand include cutaneous, subcutaneous, and deep. Cutaneous infections are caused by organisms that metabolize keratin and can cause serious morbidity but are rarely fatal. Read More

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http://dx.doi.org/10.1016/j.hcl.2020.03.009DOI Listing

Sporotrichosis in renal transplant patients: two case reports and a review of the literature.

J Med Case Rep 2020 Jun 26;14(1):79. Epub 2020 Jun 26.

Division of Nephrology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

Introduction: Sporotrichosis is a rare fungal infection in transplant patients; among these patients, it occurs mostly in renal transplant patients. Sporothrix schenkii is the primary pathogen responsible. A high index of suspicion is required to make the diagnosis keeping important differential diagnoses in mind. Read More

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http://dx.doi.org/10.1186/s13256-020-02385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318768PMC

Infection caused by Sporothrix schenckii: an autochthonous case in Bari, Southern Italy.

Eur J Clin Microbiol Infect Dis 2020 Jun 20. Epub 2020 Jun 20.

Clinic of Infectious Diseases, University of Bari Aldo Moro, 70124, Bari, Italy.

An autochthonous case of lymphocutaneous sporotrichosis caused by Sporothrix schenckii is reported. The patient developed skin lesions localized along the lymphatics that appeared after he suffered an injury while collecting wicker canes in marshy water. The fungus was identified as Sporothrix schenckii by MALDI-TOF and sequencing. Read More

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http://dx.doi.org/10.1007/s10096-020-03939-zDOI Listing

In vitro antifungal susceptibility of Sporothrix globosa isolates from Jilin Province, northeastern China: comparison of yeast and mycelial phases.

Braz J Microbiol 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology and Venereology, First Hospital of Jilin University, Changchun, China.

The dimorphic fungus Sporothrix globosa is the predominant etiologic agent causing sporotrichosis in China, particularly in the northeast. It has been demonstrated that the incubation temperature and growth phase can influence in vitro antifungal susceptibility profiles of S. schenckii sensu stricto and S. Read More

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http://dx.doi.org/10.1007/s42770-020-00316-yDOI Listing

A case of sporotrichosis infection mimicking pyoderma gangrenosum and the role of tissue culture in diagnosis: A case report.

SAGE Open Med Case Rep 2020 18;8:2050313X20919600. Epub 2020 May 18.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Sporotrichosis infections may cause cutaneous lesions mimicking other infectious or non-infectious causes such as pyoderma gangrenosum. We present a case of cutaneous sporotrichosis misdiagnosed as pyoderma gangrenosum and treated with immunosuppressants for 17 months leading to exacerbation and atypical morphology mimicking organisms on biopsy. Exclusion of infection prior to diagnosing pyoderma gangrenosum is important to prevent iatrogenic immunosuppression, demonstrating the challenges with application of the updated pyoderma gangrenosum diagnostic criteria. Read More

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http://dx.doi.org/10.1177/2050313X20919600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235660PMC

Cutaneous leishmaniasis: A great imitator.

Clin Dermatol 2020 Mar - Apr;38(2):140-151. Epub 2019 Oct 24.

Department of Dermatology, Akdeniz University, School of Medicine, Antalya, Turkey.

Cutaneous leishmaniasis (CL) is called "the great imitator," because it can mimic almost all types of dermatoses. This similarity may sometimes lead to misdiagnosis, resulting in inappropriate treatment and morbidities. Atypical forms occur due to the interaction between parasitic factors and the host immune response. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.008DOI Listing
October 2019

Atypical sporotrichosis related to Sporothrix mexicana.

Mycopathologia 2020 Jun 4. Epub 2020 Jun 4.

Departamento de Microbiología, Facultad de Medicina de Nuevo León, Monterrey, Mexico.

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http://dx.doi.org/10.1007/s11046-020-00463-8DOI Listing

Antifungal resistance on Sporothrix species: an overview.

Braz J Microbiol 2020 May 31. Epub 2020 May 31.

Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Introduction: The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this.

Methodology: Published data on databases (PubMed, Science Direct, Google Scholar) were investigated using a combination of keywords from 2008 to 2019 by the StArt tool. Read More

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http://dx.doi.org/10.1007/s42770-020-00307-zDOI Listing

Pulse itraconazole in the treatment of lymphocutaneous sporotrichosis: A case report from Southern Italy and review of the literature.

Dermatol Ther 2020 May 30:e13716. Epub 2020 May 30.

Department of Clinical and Experimental Medicine-Dermatology, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1111/dth.13716DOI Listing

Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil.

PLoS Negl Trop Dis 2020 May 26;14(5):e0008141. Epub 2020 May 26.

Laboratório de Micologia Médica e Molecular, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brasil.

Background: A relevant case of pulmonary sporotrichosis due to Sporothrix brasiliensis is reported in a 50-year-old immunocompetent woman who had no history of skin trauma, but was in close contact with several stray cats at her nap time. The patient was hospitalized after 7 months of illness. The survey was conducted for pulmonary tuberculosis, an endemic disease in Brazil. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274469PMC

Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome.

Braz J Microbiol 2020 May 22. Epub 2020 May 22.

Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil.

Sporotrichosis in immunocompromised patients has a high morbidity and may cause deaths. Particularly, patients with acquired immunodeficiency syndrome (AIDS) with low T CD4 counts develop a chronic disease, with severe and widespread forms. Recently, the ability of Sporothrix brasiliensis, the main agent of zoonotic sporotrichosis, to increase its virulence in a diabetic patient without HIV infection was described. Read More

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http://dx.doi.org/10.1007/s42770-020-00297-yDOI Listing

Case series of sporotrichosis at a teaching hospital in Brazil.

Rev Soc Bras Med Trop 2020 18;53:e20190509. Epub 2020 May 18.

Departamento de Clínica Médica, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.

Introduction: Sporotrichosis is a subcutaneous fungal infection with a worldwide distribution and higher incidence in tropical and subtropical areas, such as the Brazilian territory, where it has been standing out due to its frequent epidemics. Thus, the present study aimed to evaluate the prevalence of sporotrichosis and profile the affected patients at a university teaching hospital in the central region of Rio Grande do Sul, Brazil.

Methods: This study was a case series of patients diagnosed with Sporothrix spp. Read More

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http://dx.doi.org/10.1590/0037-8682-0509-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269531PMC

inhibitory effect of statins on planktonic cells and biofilms of the species complex.

J Med Microbiol 2020 Jun 12;69(6):838-843. Epub 2020 May 12.

Postgraduate in Veterinary Sciences, Faculty of Veterinary, State University of Ceará, Fortaleza, Ceará, 60714-903, Brazil.

Sporotrichosis, caused by species of the complex, is the most prevalent subcutaneous mycosis in many areas of Latin America. Statins are a class of drugs widely used for lowering high sterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of sterol. In this study, the antifungal activity of statins (simvastatin, atorvastatin, pravastatin) against planktonic cells and biofilms of complex species was evaluated, as well as the interaction of pravastatin with classical antifungals (amphotericin B, itraconazole, terbinafine). Read More

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http://dx.doi.org/10.1099/jmm.0.001195DOI Listing
June 2020
2.248 Impact Factor

Seroepidemiological survey on sporotrichosis-infection in rural areas of the south of Minas Gerais State, Brazil.

Braz J Microbiol 2020 May 13. Epub 2020 May 13.

Departamento de Microbiologia e Imunologia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, Minas Gerais, 37130-001, Brazil.

Sporotrichosis is a subcutaneous mycosis caused by traumatic inoculation into the skin by fungi species of the genus Sporothrix. The disease has different clinical manifestations (cutaneous, lymphocutaneous, and disseminated), and can also progress to a systemic infection. Despite having a worldwide distribution, sporotrichosis is most prevalent in tropical and subtropical countries. Read More

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http://dx.doi.org/10.1007/s42770-020-00279-0DOI Listing

Disseminated Sporotrichosis With Brain Abscesses in an HIV-Infected Patient.

Cureus 2020 May 7;12(5):e8016. Epub 2020 May 7.

Infectious Disease, University of Kansas School of Medicine, Wichita, USA.

Sporotrichosis is a mycotic infection caused by the Sporothrix schenckii species complex. It typically presents as a localized, mostly cutaneous or lymphocutaneous infection, but has been increasingly presenting as a disseminated infection in immunocompromised individuals, especially in HIV/AIDS patients. We also included a literature review of sporotrichosis in this patient population. Read More

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http://dx.doi.org/10.7759/cureus.8016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212747PMC

Feline sporotrichosis: a case series of itraconazole-resistant Sporothrix brasiliensis infection.

Braz J Microbiol 2020 May 9. Epub 2020 May 9.

Department of Veterinary Clinic, Faculty of Veterinary, Federal University of Pelotas, 1 Campus Universitário Capão do Leão, Pelotas/RS, Rio Grande do Sul, 96010-900, Brazil.

The treatment of feline sporotrichosis is a challenge for veterinary clinicians since refractory cases may occur, due either to patient and/or to pharmacological management errors or due to the development of antifungal resistance. Thus, we aimed to describe the therapeutic history of feline cases infected by itraconazole-resistant Sporothrix brasiliensis in an endemic region of Southern Brazil. Medical records of cats attended at the Veterinary Clinic Hospital (Pelotas/RS, Brazil) between 2016 and 2017 were reviewed. Read More

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http://dx.doi.org/10.1007/s42770-020-00290-5DOI Listing

Human serum proteins bind to Sporothrix schenckii conidia with differential effects on phagocytosis.

Braz J Microbiol 2020 May 7. Epub 2020 May 7.

Unidad de Investigación en Medicina Experimental, Micología Básica, Facultad de Medicina, Universidad Nacional Autónoma de México, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, Mexico.

Serum is an important source of proteins that interact with pathogens. Once bound to the cell surface, serum proteins can stimulate the innate immune system. The phagocytosis of Sporothrix schenckii conidia by human macrophages is activated through human serum opsonisation. Read More

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http://dx.doi.org/10.1007/s42770-020-00276-3DOI Listing

Feline sporotrichosis in Asia.

Braz J Microbiol 2020 May 3. Epub 2020 May 3.

Department of Veterinary Dermatology, Nihon University College of Bioresource Sciences, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.

Sporothrix schenckii sensu lato is currently recognized as a species complex with only Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa and Sporothrix pallida identified to cause disease in the cat. Feline sporotrichosis in Asia is mainly reported from Malaysia where a single clonal strain of clinical clade D, Sporothrix schenckii sensu stricto manifesting low susceptibility to major antifungal classes, has been identified as the agent of the disease. Sporothrix globosa has been identified to cause disease from a single cat in Japan while the specific species of agent has not been identified yet for the disease in Thailand. Read More

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http://dx.doi.org/10.1007/s42770-020-00274-5DOI Listing

Dermatoscopic features of cutaneous sporotrichosis.

J Eur Acad Dermatol Venereol 2020 Apr 28. Epub 2020 Apr 28.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/jdv.16539DOI Listing
April 2020
2.826 Impact Factor

Susceptibility and resistance of Sporothrix brasiliensis to branded and compounded itraconazole formulations.

Braz J Microbiol 2020 Apr 24. Epub 2020 Apr 24.

Departamento de Veterinária Preventiva, Faculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.

Itraconazole is the first drug of choice for the treatment of sporotrichosis and it is available at different concentrations for veterinary patients. However, therapeutic failure has been reported, limiting clinical treatment. This study evaluated the in vitro efficacy of brand-name and compounded itraconazole formulations against Sporothrix brasiliensis and estimated the itraconazole content in each tested formulation. Read More

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http://dx.doi.org/10.1007/s42770-020-00280-7DOI Listing

Coinfection of domestic felines by distinct Sporothrix brasiliensis in the Brazilian sporotrichosis hyperendemic area.

Fungal Genet Biol 2020 Jul 20;140:103397. Epub 2020 Apr 20.

Center for Microorganisms' Investigation, Federal Fluminense University, Niterói, RJ, Brazil. Electronic address:

Microbial interactions may impact patient's diagnosis, prognosis and treatment. Sporotrichosis is a hyperendemic neglected zoonosis in Brazil, caused by Sporothrix brasiliensis. Four pairs of clinical isolates of Sporothrix were recovered from four diseased cats (CIM01-CIM04, two isolates per animal) raising the possibility of coinfection in a sporotrichosis hyperendemic area, Brazil. Read More

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http://dx.doi.org/10.1016/j.fgb.2020.103397DOI Listing
July 2020
2.587 Impact Factor

A case of sporotrichosis.

Int J Infect Dis 2020 Apr 17;96:163-164. Epub 2020 Apr 17.

Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China; Research Center for Medical Mycology, Peking University, Beijing, China; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China; National Clinical Research Center for Skin and Immune Diseases, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2020.04.032DOI Listing

Systemic sporotrichosis in an alcoholic patient.

An Bras Dermatol 2020 May - Jun;95(3):376-378. Epub 2020 Mar 20.

Department of Dermatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

A 44-year-old male patient presented with nodules that evolved with inflammation, following drainage of seropurulent secretion and ulceration. The patient had a 6 year-history of alcohol addiction and reported contact with cats. At the physical examination, the patient had skin-colored and erythematous nodules, and ulcers covered with thick, blackened crusts on the face, trunk and limbs. Read More

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http://dx.doi.org/10.1016/j.abd.2019.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253905PMC

Ste20 is crucial for dimorphic switching of sporothrix schenckii and affects its global transcriptome.

Int J Clin Exp Pathol 2020 1;13(3):411-424. Epub 2020 Mar 1.

Department of Microecology, College of Basic Medical Science, Dalian Medical University China.

induced sporotrichosis has gained importance in recent years because of its worldwide prevalence. The dimorphic switching process is required for the pathogenesis of . Previously, we found that STE20-like protein kinase (SsSte20) was overexpressed in the early yeast stage, but not in the mycelial stage of , which suggested its involvement in morphogenesis of this fungal pathogen. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137016PMC

Skin Mast Cells Contribute to Infection.

Front Immunol 2020 19;11:469. Epub 2020 Mar 19.

Department of Dermatology, First Hospital, Peking University, Beijing, China.

(), a dimorphic fungus, causes sporotrichosis. Mast cells (MCs) have been described to be involved in skin fungal infections. The role of MCs in cutaneous sporotrichosis remains largely unknown. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096480PMC

Formulation and Evaluation of a Novel Itraconazole-Clotrimazole Topical Emulgel for the Treatment of Sporotrichosis.

Curr Pharm Des 2020 ;26(14):1566-1570

Pharmaceutical Technology Department, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói-RJ, Brazil.

In recent years, the development of new pharmaceutical formulations for the treatment of sporotrichosis has become a relevant research field. In this work, we aimed to develop an emulgel containing itraconazole and clotrimazole to ensure therapeutic effectiveness against Sporothrix brasiliensis. The topical use of a formulation that combines both drugs represents an interesting option for the complementary treatment of sporotrichosis. Read More

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http://dx.doi.org/10.2174/1381612826666200406081249DOI Listing
January 2020

Deep fungal infections diagnosed by histology in Uganda: a 70-year retrospective study.

Med Mycol 2020 Apr 3. Epub 2020 Apr 3.

Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Fungal infections cause substantial morbidity and mortality. However, the burden of deep fungal infections is not well described in Uganda. We aimed to estimate the burden and etiology of histologically diagnosed deep fungal infections in Uganda. Read More

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http://dx.doi.org/10.1093/mmy/myaa018DOI Listing
April 2020
2.335 Impact Factor

Is Sporothrix chilensis circulating outside Chile?

PLoS Negl Trop Dis 2020 03 30;14(3):e0008151. Epub 2020 Mar 30.

Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.

Sporothrix chilensis is a mild-pathogenical specie of Sporothrix pallida complex, until now, known as restrict to Chile. Herein, we describe the first clinical isolates identified as S. chilensis in Brazil, preserved in the URM Culture Collection, by polyphasic taxonomy, and their respective antifungal profile of this emergent fungus. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162539PMC

Therapeutic failure with itraconazole in sporotrichosis due to bariatric surgery.

An Bras Dermatol 2020 Mar - Apr;95(2):241-243. Epub 2020 Feb 12.

Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

Sporotrichosis is a deep mycosis of subacute or chronic evolution, caused by the dimorphic fungus of the genus Sporothrix. The treatment is carried out with antifungal orally or intravenously. Therapeutic success can be affected by several factors, such as altered gastrointestinal physiology by surgery. Read More

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http://dx.doi.org/10.1016/j.abd.2019.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175040PMC

Localized sporotrichosis during natalizumab treatment in Multiple Sclerosis.

Mult Scler Relat Disord 2020 Jun 26;41:102029. Epub 2020 Feb 26.

Department of Neurology, Department of Internal Medicine, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2020.102029DOI Listing

One Health Education for Future Physicians: A Case Report of Cat-Transmitted Sporotrichosis.

Open Forum Infect Dis 2020 Mar 12;7(3):ofaa049. Epub 2020 Feb 12.

Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

A healthy 35-year-old Brazilian woman presented with persistent redness, swelling, and multiple wounds on the hand 2 weeks after a cat bite in her home country. She was treated twice with amoxicillin-clavulanate but failed to demonstrate improvement. She then presented to our institution with a newly developed abscess on the right hand. Read More

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http://dx.doi.org/10.1093/ofid/ofaa049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052747PMC

Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and spp.

Antimicrob Agents Chemother 2020 04 21;64(5). Epub 2020 Apr 21.

Departamento de Química, ICE, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil

The new complexes Zn(ITZ)Cl (1) and Zn(ITZ)(OH) (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spectrometry, H and C{H} nuclear magnetic resonance, and UV-vis and infrared spectroscopies. The antiparasitic and antifungal activity of Zn-ITZ complexes was evaluated against three protozoans of medical importance, namely, , , and , and two fungi, namely, and The Zn-ITZ complexes exhibited a broad spectrum of action, with antiparasitic and antifungal activity in low concentrations. Read More

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http://dx.doi.org/10.1128/AAC.01980-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179638PMC

Development, skin targeting and antifungal efficacy of topical lipid nanoparticles containing itraconazole.

Eur J Pharm Sci 2020 Mar 7;149:105296. Epub 2020 Mar 7.

Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

Considering the increased incidence of sporotrichosis and other fungal infections in rural and urban areas, and the limitations and adverse effects of oral itraconazole therapy, we studied nanostructured lipid carriers (NLC) as topical delivery systems to increase itraconazole localization in skin lesions and associate efficacy with reduced systemic exposure. Unloaded and itraconazole-loaded NLC showed nanometric size (~216-340 nm), negative zeta potential (~ -17 mV), and high entrapment efficiency (~97%). NLC treatment decreased transepidermal water loss, an index of cutaneous barrier function, in intact skin and in tissues damaged with a linear incision (to mimic lesions) by 23-36%, and reduced drug transdermal delivery by ~2-fold, demonstrating its ability to localize itraconazole within the skin. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105296DOI Listing

Sporotrichosis: A Clinicopathologic Study of 89 Consecutive Cases, Literature Review, and New Insights About Their Differential Diagnosis.

Am J Dermatopathol 2020 Mar 6. Epub 2020 Mar 6.

Department of Pathology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.

Background: Sporotrichosis is the most common and least severe of deep mycoses. This disease has varied clinic presentation as well as several differential diagnosis.

Methods: A cross-sectional and retrospective, individually based, observational study, based on records from the dermatopathology service of a university hospital in Brazil. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001617DOI Listing

Associated factors and spatial patterns of the epidemic sporotrichosis in a high density human populated area: A cross-sectional study from 2016 to 2018.

Prev Vet Med 2020 Mar 25;176:104939. Epub 2020 Feb 25.

Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

An epidemiological characterization of human and feline sporotrichosis was carried out between 2016 and 2018, in a high density-populated area in Brazil. Professionals were trained to identify suspect cats and notify vets to interview the owners and collect swabs of the wounds from these animals. Mycological cultures were performed, and colonies identified as Sporothrix spp. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2020.104939DOI Listing
March 2020
2.167 Impact Factor

Sporotrichosis: The case series in Thailand and literature review in Southeast Asia.

Med Mycol Case Rep 2020 Mar 16;27:59-63. Epub 2020 Jan 16.

Division of Infectious Disease, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.

Human Sporotrichosis is an infection caused by dimorphic fungus, complex, via direct inoculation. We are herein report proven 2 cases of sporotrichosis along with a literature review about human sporotrichosis in the southeast Asian region. The first case was a 76-year-old female with a non-progressive erythematous plaque at the right ankle. Read More

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http://dx.doi.org/10.1016/j.mmcr.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036545PMC

First case report of cutaneous sporotrichosis ( species) in a cat in the UK.

JFMS Open Rep 2020 Jan-Jun;6(1):2055116920906001. Epub 2020 Feb 14.

Dermatology Service, Hospital for Small Animals, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Roslin, UK.

Case Summary: A 12-year-old female neutered indoor-outdoor domestic longhair cat presented with frequent sneezing and a nodular, suppurative lesion on its dorsal nose. Histopathological examination revealed a fungal granuloma. PCR and sequencing of the ribosomal internal transcribed spacers (ITS) regions (ITS-F and ITS-R) confirmed an infection with a species. Read More

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http://dx.doi.org/10.1177/2055116920906001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025424PMC
February 2020

Anti-Inflammatory Effects of Potassium Iodide on SDS-Induced Murine Skin Inflammation.

J Invest Dermatol 2020 Feb 25. Epub 2020 Feb 25.

Department of Dermatology, Dokkyo Medical University, School of Medicine, Shimotsuga, Tochigi, Japan.

Potassium iodide (KI), initially derived from seaweed in the early 19th century, is used for treating sporotrichosis in dermatological practice. KI has also been used to treat several noninfectious inflammatory skin diseases. However, the mechanisms underlying the improvement in such skin diseases remain unknown, and KI is not used widely. Read More

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http://dx.doi.org/10.1016/j.jid.2020.01.028DOI Listing
February 2020

Geographic Expansion of Sporotrichosis, Brazil.

Emerg Infect Dis 2020 Mar;26(3):621-624

Brazil has experienced geographic expansion of zoonotic sporotrichosis. Social problems in the country contribute substantially to the expansion. A comprehensive sporotrichosis control program is beyond the sphere of public health. Read More

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http://dx.doi.org/10.3201/eid2603.190803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045854PMC

Sporotrichosis in Brazil: Animals+humans=one health.

Rev Iberoam Micol 2020 Feb 18. Epub 2020 Feb 18.

Veterinary Mycology Group, Department of Animal Health and Anatomy, Veterinary School, Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.riam.2020.01.001DOI Listing
February 2020

Diagnosis of human sporotrichosis in Campos dos Goytacazes, Rio de Janeiro, Brazil.

J Infect Dev Ctries 2019 08 31;13(8):768-772. Epub 2019 Aug 31.

Adult Health Department, Campos School of Medicine, Campos dos Goytacazes, RJ, Brazil.

Introduction: Sporotrichosis is an infectious fungal zoonosis associated with traumatic implantation in the skin of dimorphic fungi of the Sporothrix schenckii complex. The objective of this study was to diagnose sporotrichosis in patients in the city of Campos dos Goytacazes, and to establish correlations between positive laboratory results and dermatological and topographical aspects of the lesions and personal traits of the patients, such as sex, age and profession.

Methodology: We collected samples from 22 patients with suspect lesions, which were sent to the laboratory for direct microscopic analysis after Gram staining, followed by mycological culture by seeding the material in 4% Sabouraud dextrose agar (Himedia®) supplemented with chloramphenicol (50 mg/Lt) and cycloheximide (400 mg/Lt - Sigma-Aldrich, USA). Read More

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http://dx.doi.org/10.3855/jidc.11672DOI Listing

The threat of emerging and re-emerging pathogenic Sporothrix species.

Mycopathologia 2020 Feb 12. Epub 2020 Feb 12.

Laboratory of Emerging Fungal Pathogens, Cell Biology Division, Department of Microbiology, Immunology and Parasitology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, 04023-062, Brazil.

Sporotrichosis is a neglected subcutaneous mycosis of humans and animals acquired by traumatic inoculation of soil and plant material (classical route) contaminated with infectious propagules of the pathogen or being bitten/scratched by infected cats (alternative route). Within a genus composed of 53 species displaying an essentially environmental core, there are only a few members which have considerable impacts on human or animal health. Infections are typically caused by S. Read More

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http://dx.doi.org/10.1007/s11046-020-00425-0DOI Listing
February 2020
1.528 Impact Factor

Tumorous formation of the forehead.

Wien Med Wochenschr 2020 May 28;170(7-8):196-198. Epub 2020 Jan 28.

Onkoderma - Clinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia, Bulgaria.

T‑cell non-Hodgkin's lymphoma (NHL) represents approximately 10% to 15% of all lymphomas in Western countries. We present the case of a 16-year-old girl with nodular erosive tumor formation on the forehead within the previous 3-4 months and clinical evidence of cervical and submandibular lymphadenopathy in parallel. Tuberculosis verrucosa cutis, lupus vulgaris, cutaneous leishmaniasis, pyoderma faciale, sporotrichosis, infected insect bite, B‑cell lymphoma, and atypical acneiform eruption were considered in the differential diagnosis. Read More

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http://dx.doi.org/10.1007/s10354-019-00730-4DOI Listing

Arm Sporotrichosis Secondary to Scratching Finger Verruca Vulgaris.

Mycopathologia 2020 04 23;185(2):413-414. Epub 2020 Jan 23.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.

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http://dx.doi.org/10.1007/s11046-020-00426-zDOI Listing

Proteomic analysis of Sporothrix schenckii cell wall reveals proteins involved in oxidative stress response induced by menadione.

Microb Pathog 2020 Apr 19;141:103987. Epub 2020 Jan 19.

Facultad de Ciencias Químicas (Unidad Durango), Universidad Juárez del Estado de Durango, Durango, Av. Veterinaria S/N, 34120, Durango, Dgo, Mexico. Electronic address:

Sporotrichosis is an emergent subcutaneous mycosis that is a threat to both humans and other animals. Sporotrichosis is acquired by the traumatic implantation of species of the Sporothrix genus. Added to the detoxification systems, pathogenic fungi possess different mechanisms that allow them to survive within the phagocytic cells of their human host during the oxidative burst. Read More

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http://dx.doi.org/10.1016/j.micpath.2020.103987DOI Listing

North American blastomycosis in an immunocompromised patient.

Cutis 2019 Dec;104(6):E18-E21

Dermatology and Laser Group of Irvine, California, and is affiliated with Hoag Hospital Irvine, California, USA.

Blastomycosis is a subacute or chronic deep mycosis caused by a dimorphic fungus, Blastomyces dermatitidis, that generally produces a pulmonary form of the disease and, to a lesser extent, extrapulmonary forms, such as cutaneous, osteoarticular, and genitourinary. Both immunocompetent and immunocompromised individuals can be infected, but more severe disease occurs in the immunocompromised. Blastomycosis can be diagnosed by culture, direct visualization of the yeast in affected tissue, antigen testing, or a combination of these methods. Read More

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December 2019

Sensitivities of periodic acid-Schiff staining, Grocott's silver staining and calcofluor white staining in the diagnosis of human sporotrichosis.

Int J Clin Exp Pathol 2019 1;12(9):3459-3464. Epub 2019 Sep 1.

Department of Dermatology, The Second Hospital of Jilin University Jilin, China.

Objective: This study aimed to investigate the sensitivity of periodic acid-Schiff (PAS) staining, Grocott's silver staining (GSS) and calcofluor white (CFW) staining in the diagnosis of sporotrichosis.

Methods: Paraffin embedded tissues (n = 100) which were diagnosed with sporotrichosis by fungal culture were subjected to PAS, GSS, and CFW staining, and the detection rate of sporotrichosis was determined.

Results: The sensitivity of PAS, GSS, and CFW staining was 31%, 40% and 74%, respectively, in the diagnosis of sporotrichosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949826PMC
September 2019

Antifungal activity of silver salts of Keggin-type heteropolyacids against spp.

J Microbiol Biotechnol 2020 Apr;30(4):540-551

Laboratório de Sanidade Animal, Hospital Veterinário, Centro de Ciências e Tecnologias Agropecuárias, Universidade Estadual do Norte Fluminense Darcy Ribeiro, 28013-602, Campos dos Goytacazes, Rio de Janeiro, Brazil.

Sporotrichosis is a chronic and subacute mycosis causing epidemiological outbreaks involving sick cats and humans in southeastern Brazil. The systemic disease prevails in cats, and in humans, the symptoms are restricted to skin in immunocompetent individuals. Under these conditions, the prolonged treatment of animals and cases of recurrence justify the discovery of new treatments for sporotrichosis. Read More

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http://dx.doi.org/10.4014/jmb.1907.07064DOI Listing