139 results match your criteria Spontaneous Primary Ovarian Insufficiency and Premature Ovarian Failure


Metabolic profile of women with premature ovarian insufficiency compared with that of age-matched healthy controls.

Maturitas 2021 Jun 20;148:33-39. Epub 2021 Apr 20.

Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. Electronic address:

Objective: . To compare the metabolic profile of women with spontaneous premature ovarian insufficiency (POI) with that of age-matched healthy controls.

Study Design: . Read More

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Subsequent menstrual disorder after spontaneous menarche in Turner syndrome.

Clin Endocrinol (Oxf) 2021 Jul 7;95(1):163-168. Epub 2021 Mar 7.

Komura Women's Clinic, Osaka, Japan.

Objective: Turner syndrome (TS) is a congenital disease characterized by delayed puberty, ovarian dysgenesis and short stature. Although most patients are diagnosed with primary amenorrhea, approximately 15-20% of patients with TS are reported to have spontaneous menarche. However, little is known about their menstruation status after spontaneous menarche. Read More

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Dehydroepiandrosterone supplementation improves ovarian reserve and pregnancy rates in poor responders.

Authors:
M D Ozcil

Eur Rev Med Pharmacol Sci 2020 09;24(17):9104-9111

Department of Obstetrics and Gynecology, Mustafa Kemal University School of Medicine, Hatay, Turkey.

Objective: We investigated whether DHEA supplementation had an impact on ovarian reserve parameters and pregnancy rates in patients with poor ovarian response (POR) and primary ovarian insufficiency (POI).

Patients And Methods: A total of 34 people, 6 patients with POI and 28 patients with POR, were included in the study. The patients in the POR group consisted of two different groups: diminished ovarian reserve (DOR) and premature ovarian failure (PMOF). Read More

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September 2020

Anti-Müllerian hormone as a qualitative marker - or just quantity?

Curr Opin Obstet Gynecol 2020 06;32(3):219-226

Department of Obstetrics, Gynecology, and Reproductive Sciences, Section of Reproductive Endocrinology and Infertility, Yale University, New Haven, Connecticut, USA.

Purpose Of Review: In this review, we will summarize research looking into anti-Müllerian hormone (AMH) as a measure of oocyte quality.

Recent Findings: AMH is a key factor involved in embryogenesis but also in the development of early follicles. Owing to its relatively small inter and intracycle variability, it has become a widely used method of ovarian reserve testing. Read More

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Successful Spontaneous Pregnancy and Live Birth in a Woman With Premature Ovarian Insufficiency and 10 Years of Amenorrhea: A Case Report.

Authors:
Ying Gu Yan Xu

Front Med (Lausanne) 2020 7;7:18. Epub 2020 Feb 7.

Department of Gynaecology and Obstetrics, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Primary ovarian insufficiency (POI) is a devastating diagnosis for reproductive-aged women due to the associated infertility and other serious health consequences. Spontaneous pregnancy without hormone replacement therapy (HRT) and/or assisted reproductive technology (ART) rarely occurs in POI patients, particularly in those patients with long-term amenorrhea. On March 4, 2019, a 31-year-old Chinese POI patient visited our hospital for a spontaneous pregnancy after 10 years of amenorrhea and discontinuation of HRT 4 years prior. Read More

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February 2020

Ovarian Cortex Transplantation.

J Minim Invasive Gynecol 2020 Sep - Oct;27(6):1253. Epub 2019 Dec 12.

Assisted Reproductive Technique Unit (Dr. Pirrello), CMCO, University Hospital of Strasbourg.

Study Objective: To describe a laparoscopic technique for the transplantation of a cryopreserved ovarian cortex.

Design: Educational video.

Setting: University Hospital of Strasbourg, France. Read More

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January 2021

Ovarian reserve evaluation in a woman with 45,X/47,XXX mosaicism: A case report and a review of literature.

Mol Genet Genomic Med 2019 07 8;7(7):e00732. Epub 2019 May 8.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People's Republic of China.

Background: Turner syndrome (TS) is a common chromosomal disorder affecting approximately 1:2,500 live female births. Mosaic 47,XXX karyotype is found in 3%-4% of TS patients. TS phenotype in rare 45,X/47,XXX mosaicism patients is milder than in classic TS, however their ovarian function, especially in the mature age, has not been described in detail. Read More

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Sexuality in premature ovarian insufficiency.

Climacteric 2019 06 22;22(3):289-295. Epub 2019 Mar 22.

a Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, Obstetrics and Gynecology Unit, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences , University of Pavia , Pavia , Italy.

Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function. Early hormonal deprivation gives origin to symptomatic vulvovaginal atrophy and contributes to hypoactive sexual desire disorder modulating central and peripheral circuitries, which regulate sexual response. Read More

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Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure.

Curr Opin Obstet Gynecol 2019 06;31(3):156-162

Fundación IVI.

Purpose Of Review: We review the techniques recently tested in both animal models and humans to provide a state-of-the-art on adult stem cell ovarian transplant to achieve ovarian rejuvenation in patients with diminished ovarian reserves.

Recent Findings: As the firsts reports of spontaneous pregnancies achieved after bone marrow transplantation in oncologic women with primary ovarian insufficiency, increasing evidence supports the regenerative effects of stem cell-based therapies in the ovarian niche. Adult stem cells from several origins promote follicular development, increase ovarian local vascularization, increase follicle and stromal cell proliferation and reduce cell apoptosis and follicular atresia, although they do not modify embryo quality. Read More

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Consequences of premature ovarian insufficiency on women's sexual health.

Prz Menopauzalny 2018 Sep 30;17(3):127-130. Epub 2018 Sep 30.

Department of Gynaecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.

Premature ovarian insufficiency (POI) is defined by amenorrhoea and decreased serum levels of oestrogens associated with increased serum gonadotropins concentrations before the age of 40 years. Patients suffering from POI present with irregular menses, either secondary or (less common) primary amenorrhoea, and subfertility. POI affects approximately 1 in 100 women by the age 40 years and 0. Read More

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September 2018

Triptorelin for Fertility Preservation in Adolescents Treated With Chemotherapy for Cancer.

J Pediatr Hematol Oncol 2018 05;40(4):269-276

Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.

Background: Triptorelin, a gonadotropin releasing hormone analogue, can be administered to postpubertal female individuals with cancer who receive chemotherapy to obtain menstrual suppression and decrease the risk of hemorrhage caused by thrombocytopenia. Our goal was to assess whether triptorelin also has a protective role against the gonadotoxicity of chemotherapy.

Patients And Methods: This retrospective observational study includes all postmenarchal female patients who presented to our Unit from 2000 to 2015 and received chemotherapy for cancer. Read More

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TMCO1 is essential for ovarian follicle development by regulating ER Ca store of granulosa cells.

Cell Death Differ 2018 09 21;25(9):1686-1701. Epub 2018 Feb 21.

State Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 100101, Beijing, China.

TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER) transmembrane protein that actively prevents Ca stores from overfilling. To characterize its physiological function(s), we generated Tmco1 knockout (KO) mice. In addition to the main clinical features of human cerebrofaciothoracic (CFT) dysplasia spectrum, Tmco1 females manifest gradual loss of ovarian follicles, impaired ovarian follicle development, and subfertility with a phenotype analogous to the premature ovarian failure (POF) in women. Read More

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September 2018

Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency.

Authors:

Obstet Gynecol 2017 05;129(5):e134-e141

Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

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Committee Opinion No. 698 Summary: Hormone Therapy in Primary Ovarian Insufficiency.

Authors:

Obstet Gynecol 2017 May;129(5):963-964

Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

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Efficacy of ovarian tissue cryopreservation for fertility preservation: lessons learned from 545 cases.

Hum Reprod 2017 05;32(5):1046-1054

Gynecology Department, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCL) and Cliniques Universitaires Saint-Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium.

Study Question: How effective is ovarian tissue cryopreservation (OTC)?

Summary Answer: In our cohort of patients who underwent OTC, premature ovarian failure (POF) rates, return rates and pregnancy rates after autotransplantation were 31.5, 4.4 and 33%, respectively. Read More

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Differentiating the Causes of Spontaneous Rib Fracture After Breast Cancer.

Authors:
Susan R Harris

Clin Breast Cancer 2016 12 15;16(6):431-436. Epub 2016 Jul 15.

Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia. Electronic address:

Spontaneous rib fracture after treatment for primary breast cancer is not uncommon. Although metastatic disease accounts for about 30% of spontaneous rib fractures and should constitute the first line of diagnostic investigation, other possible contributors include primary osteoporosis or secondary osteoporosis resulting from cancer treatments. Chemotherapy-induced menopause, aromatase inhibitors, radiation therapy, and long-term bisphosphonate use can all contribute to bone fragility, including spontaneous rib fractures in the latter 3. Read More

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December 2016

Hormone Replacement Therapy Versus the Combined Oral Contraceptive Pill in Premature Ovarian Failure: A Randomized Controlled Trial of the Effects on Bone Mineral Density.

J Clin Endocrinol Metab 2016 09 24;101(9):3497-505. Epub 2016 Jun 24.

Menopause Research Unit (B.C., J.Ro., J.Ry.), McNair Centre, and Department of Nuclear Medicine (I.F.), Guy's Hospital, London, SE1 9RT, United Kingdom; and Department of Women's Health (P.T.S.), St Thomas' Hospital, London SE1 7EH, United Kingdom.

Context: Women with premature ovarian failure (POF) face many years of estrogen deficiency. One of the major consequences is bone loss. The optimal form of estrogen replacement is unknown and management is not evidence based. Read More

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September 2016

Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases.

Hum Reprod 2016 08 14;31(8):1913-25. Epub 2016 Jun 14.

Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia

Study Question: Can spontaneous premature ovarian failure (POF) patients derived from population-based biobanks reveal the association between copy number variations (CNVs) and POF?

Summary Answer: CNVs can hamper the functional capacity of ovaries by disrupting key genes and pathways essential for proper ovarian function.

What Is Known Already: POF is defined as the cessation of ovarian function before the age of 40 years. POF is a major reason for female infertility, although its cause remains largely unknown. Read More

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Autoimmune polyglandular syndrome type 3 (APS-3) among patients with premature ovarian insufficiency (POI).

Eur J Obstet Gynecol Reprod Biol 2016 Aug 20;203:61-5. Epub 2016 May 20.

Department of Gyneacological Endocrinology, Medical University of Warsaw, Ul. Karowa 2, 00-315 Warsaw, Poland.

Objectives: Autoimmune polyglandular syndrome type 3 - (APS-3), is defined as the coexistence of autoimmune thyroiditis with other non-ovarian autoimmune diseases without primary adrenal insufficiency. Additionally the definition of APS-3 also includes primary ovarian insufficiency (POI) coexistence with autoimmune thyroiditis. The main goal of that study is to assess the prevalence of APS-3 defined as coexistence of autoimmune thyroiditis with POI in population of 46 XX karyotype women with primary ovarian insufficiency (POI). Read More

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Premature ovarian insufficiency: the context of long-term effects.

J Endocrinol Invest 2016 Sep 18;39(9):983-90. Epub 2016 Apr 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, ul. Polna 33, Poznan, Poland.

Purpose: Premature ovarian insufficiency (POI) is defined as the cessation of the ovarian function before the age of 40 years. POI aetiology may be related to iatrogenic or endogenous factors and in many cases remains unclear. The aim of this review was to characterize the long-term consequences of POI. Read More

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September 2016

Analysis of FMR1 gene premutation and X chromosome cytogenetic abnormalities in 100 Tunisian patients presenting premature ovarian failure.

Ann Endocrinol (Paris) 2015 Dec 1;76(6):671-8. Epub 2015 Dec 1.

Laboratory of human cytogenetics, molecular genetics and reproductive biology, Farhat Hached university hospital, street Ibn El Jazzar, 4000 Sousse, Tunisia.

Objective: To evaluate the prevalence of FMR1 premutations and X chromosome cytogenetic abnormalities in a large cohort of Tunisian women with premature ovarian failure (POF).

Patients And Methods: The cohort consisted of 127 Tunisian women with POF referred by endocrinologists and gynecologists for genetic investigation in the context of idiopathic POF and altered hormonal profiles. Clinical information concerning the reproductive function in the family, previous hormonal measurements and/or possible fertility treatment were collected. Read More

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December 2015

Effect of primary ovarian insufficiency and early natural menopause on mortality: a meta-analysis.

Climacteric 2016 17;19(1):27-36. Epub 2015 Nov 17.

a Department of Maternal and Child Health, School of Public Health , Anhui Medical University , Hefei ;

Objective: The aim of this review was to systematically evaluate the associations of all-cause, cardiovascular and all-cancer mortality with primary ovarian insufficiency (POI) and early natural menopause (ENM).

Methods: Electronic databases for relevant studies were searched up to February 28, 2015. POI and ENM were usually defined as spontaneous menopause before age 40 years and at age 40-44 years, respectively. Read More

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October 2016

Gonadotropin-Releasing Hormone Agonist Cotreatment During Chemotherapy May Increase Pregnancy Rate in Survivors.

Oncologist 2015 Nov 13;20(11):1283-9. Epub 2015 Oct 13.

Department of Hematology, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: The use of gonadotropin-releasing hormone analogs (GnRHas) for fertility preservation is not unequivocally accepted. It is controversial whether GnRHa can increase the pregnancy rate in survivors.

Patients And Methods: This is a retrospective cohort study. Read More

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November 2015

Protecting Ovaries During Chemotherapy Through Gonad Suppression: A Systematic Review and Meta-analysis.

Obstet Gynecol 2015 Jul;126(1):187-95

Departments of Obstetrics and Gynecology, Zagazig University School of Medicine, Zagazig, and Cairo University Faculty of Medicine, El Manial, Cairo, Egypt; and the Department of Obstetrics and Gynecology, Maastricht University, Maastricht, the Netherlands.

Objective: To estimate whether gonadotropin-releasing hormone (GnRH) analog administration during chemotherapy can protect against development of ovarian toxicity.

Data Sources: MEDLINE (1966 to present), EMBASE (1980 to present), Cochrane Central Register of Controlled Trials (CENTRAL), World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov were searched through March 2015 using the phrases: "gonadotropin-releasing hormone," "chemotherapy," and "premature ovarian failure. Read More

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Spontaneous Recovery of Ovarian Function in an Adolescent with Galactosemia and Apparent Premature Ovarian Insufficiency.

J Pediatr Adolesc Gynecol 2015 Aug 16;28(4):e101-3. Epub 2014 Sep 16.

Department of Obstetrics and Gynecology, Queens University, Kingston, Ontario, Canada. Electronic address:

Background: Galactosemia is an inborn error of metabolism resulting in premature ovarian insufficiency in 80-90% of females. There have been no reported cases of biochemical ovarian failure followed by normal menses.

Case: A 12-year-old girl with galactosemia presented for gynecologic consultation. Read More

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AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients.

J Clin Endocrinol Metab 2015 Jul 15;100(7):E1030-8. Epub 2015 May 15.

Department of Gynecology/Fertility Clinic (S.Aa.L., A.T.P.), and Department of Clinical Genetics (L.A.), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark; Medical Research Council Centre for Reproductive Health (R.A.A.), University of Edinburgh, Edinburgh EH8 9YL, United Kingdom; and Department of Growth and Reproduction and EDMaRC (K.M.M., A.J., C.P.H.), and The Paed-Gyn Endo Transition Clinic (K.M.M., A.J., C.P.H., A.T.P.) at Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Context: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function.

Objectives: To evaluate the association between circulating AMH and ovarian status in TS patients. Read More

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The Turner syndrome in patient with 45X/47XXX mosaic karyotype--case report.

Gynecol Endocrinol 2015 Jul;31(7):526-8

a Department of Gynecological Endocrinology , Poznan University of Medical Sciences , Poznan , Poland.

Background: Turner syndrome (TS) is a gonadal dysgenesis related to partial or total lack of one of the X chromosomes. It this report we describe a young patient presenting some somatic features of TS, who underwent spontaneous puberty and was eumenoorheic up to the age of 23.

Methods: Using fluorescent in situ hybridization (FISH) mosaic karyotype (45X[131]/47XXX[9]) of TS and triple X syndrome was found. Read More

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The prevalence and phenotypic characteristics of spontaneous premature ovarian failure: a general population registry-based study.

Hum Reprod 2015 May 23;30(5):1229-38. Epub 2015 Feb 23.

Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, Tartu 50411, Estonia Competence Centre on Health Technologies, Tiigi 61b, Tartu 50410, Estonia Department of Obstetrics and Gynecology, University of Tartu, L. Puusepa 8, Tartu 51014, Estonia.

Study Question: What is the measured prevalence and phenotype of spontaneous premature ovarian failure (POF) in the general population?

Summary Answer: Spontaneous POF occurs in ∼1% of the general population with unique phenotype of post-menopausal ageing distinct from surgically induced premature menopause.

What Is Known Already: POF is multifactorial ovarian quiescence before the age of 40. The clinical features of POF are diverse and the population prevalence of POF is still not known. Read More

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Premature ovarian insufficiency: from pathogenesis to clinical management.

J Endocrinol Invest 2015 Jun 18;38(6):597-603. Epub 2015 Jan 18.

Department of Molecular and Developmental Medicine, Obstetrics and Gynecology, University of Siena, Policlinico "Le Scotte" Viale Bracci, 53100, Siena, Italy.

Premature ovarian insufficiency (POI) represents a condition characterized by the absence of normal ovarian function due to an incipient (by 3-10 years) ovarian aging. In most of the women affected there are no signs or symptoms that precede the interruption of menstruation and the onset of POI and the majority of women have a normal history of menarche, regular menstrual cycles and normal fertility. The possible genetic role in the development of POI has been largely demonstrated and many genes have been involved; on the other hand, ovary is not protected immunologically and the detection of autoantibodies directed against various ovarian targets strongly support the hypothesis of an autoimmune etiology. Read More

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Pituitary mass and subsequent involution causing fluctuations of serum follicle-stimulating hormone levels in a Turner syndrome patient with premature ovarian failure: a case report.

J Reprod Med 2014 Sep-Oct;59(9-10):504-8

Background: Premature ovarian failure (POF) is described as estrogen deficiency, amenorrhea, and hypergonadotropinemia in a woman < 40 years old. In a proportion of patients diagnosed with POF, intermittent and unpredictable return of ovarian function can be observed, causing fluctuations of follicle-stimulating hormone (FSH). However, these patients also have return of menstrual cycles. Read More

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December 2014