146 results match your criteria Spontaneous Primary Ovarian Insufficiency and Premature Ovarian Failure


Endometriosis in women undergoing ovarian tissue transplantation due to premature menopause after gonadotoxic treatment or spontaneous premature ovarian failure.

Acta Obstet Gynecol Scand 2022 Jul 5;101(7):771-778. Epub 2022 May 5.

Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

Introduction: Cryopreservation of ovarian tissue with subsequent transplantation is an efficient option for restoring fertility in women at risk of premature ovarian failure. The association between infertility and endometriosis is well recognized. Although endometriosis usually ends with the onset of natural or iatrogen menopause due to declining estrogen levels, endometriosis can in rare cases occur after menopause. Read More

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Two consecutive pregnancies in a patient with premature ovarian insufficiency in the course of classic galactosemia and a review of the literature.

Gynecol Endocrinol 2022 Feb 3;38(2):186-189. Epub 2021 Nov 3.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznań, Poland.

Aim: To present a case report of a patient with classic galactosemia and the Q188R/K285N GALT mutation, who conceived spontaneously twice despite severe ovarian failure. A review of the literature is included.

Materials And Methods: A 20-year-old patient with classic galactosemia and premature ovarian insufficiency (POI) came to our attention. Read More

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February 2022

Position statement on the diagnosis and management of premature/primary ovarian insufficiency (except Turner Syndrome).

Ann Endocrinol (Paris) 2021 Dec 8;82(6):555-571. Epub 2021 Sep 8.

Paris-Centre University, Hôpital Robert Debré, AP-HP, Paris, France.

Premature ovarian insufficiency (POI) is a rare pathology affecting 1-2% of under-40 year-old women, 1 in 1000 under-30 year-olds and 1 in 10,000 under-20 year-olds. There are multiple etiologies, which can be classified as primary (chromosomal, genetic, auto-immune) and secondary or iatrogenic (surgical, or secondary to chemotherapy and/or radiotherapy). Despite important progress in genetics, more than 60% of cases of primary POI still have no identifiable etiology; these cases are known as idiopathic POI. Read More

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December 2021

Metabolic profile of women with premature ovarian insufficiency compared with that of age-matched healthy controls.

Maturitas 2021 Jun 20;148:33-39. Epub 2021 Apr 20.

Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. Electronic address:

Objective: . To compare the metabolic profile of women with spontaneous premature ovarian insufficiency (POI) with that of age-matched healthy controls.

Study Design: . Read More

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Subsequent menstrual disorder after spontaneous menarche in Turner syndrome.

Clin Endocrinol (Oxf) 2021 07 7;95(1):163-168. Epub 2021 Mar 7.

Komura Women's Clinic, Osaka, Japan.

Objective: Turner syndrome (TS) is a congenital disease characterized by delayed puberty, ovarian dysgenesis and short stature. Although most patients are diagnosed with primary amenorrhea, approximately 15-20% of patients with TS are reported to have spontaneous menarche. However, little is known about their menstruation status after spontaneous menarche. Read More

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Prediction of premature ovarian insufficiency: foolish fallacy or feasible foresight?

Climacteric 2021 10 31;24(5):438-443. Epub 2021 Jan 31.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

Prediction of premature ovarian insufficiency (POI) would be of substantial individual benefit, but being a heterogeneous and fluctuating condition, with an extensive range of complex etiologies and arbitrary diagnostic criteria, might make this seem foolhardy. However, contemporary and complementary genetic strategies assessing consanguineous and large POI pedigrees and cohorts with age at natural menopause have shown strong enrichment in genes regulating DNA damage repair, homologous recombination, and meiosis, processes that are critical to oogenesis and folliculogenesis. Recognition of the molecular architecture of POI and its contribution to baseline genotypic risk may enable these estimates to be refined further by estimation of the residual ovarian reserve. Read More

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October 2021

Women's Experiences of Diagnosis and Treatment of Early Menopause and Premature Ovarian Insufficiency: A Qualitative Study.

Semin Reprod Med 2020 09 20;38(4-05):247-255. Epub 2021 Jan 20.

Social and Global Studies Centre, School of Global, Urban and Social Studies, RMIT University, Melbourne, Victoria, Australia.

Early menopause (EM) and premature ovarian insufficiency (POI) affect an estimated 10% of women and can precipitate a wide range of physiological and personal impacts. Receiving a diagnosis of EM/POI and navigating treatment can be complex experiences for women; however, qualitative research exploring these aspects of the condition is limited. Our study aimed to increase understanding of women's lived experiences of EM/POI encompassing its medical, social, and emotional dimensions. Read More

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September 2020

Ovarian antibodies among SLE women with premature menopause after cyclophosphamide.

Int J Rheum Dis 2021 Jan 10;24(1):120-124. Epub 2020 Dec 10.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Background: Women with systemic lupus erythematosus (SLE) are at risk of premature ovarian failure when treated with cyclophosphamide. This risk is increased when autoimmune thyroid disease is present. We undertook this study to determine whether the presence of ovarian autoimmunity also increased the risk of early ovarian failure among women receiving cyclophosphamide. Read More

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January 2021

Dehydroepiandrosterone supplementation improves ovarian reserve and pregnancy rates in poor responders.

Authors:
M D Ozcil

Eur Rev Med Pharmacol Sci 2020 09;24(17):9104-9111

Department of Obstetrics and Gynecology, Mustafa Kemal University School of Medicine, Hatay, Turkey.

Objective: We investigated whether DHEA supplementation had an impact on ovarian reserve parameters and pregnancy rates in patients with poor ovarian response (POR) and primary ovarian insufficiency (POI).

Patients And Methods: A total of 34 people, 6 patients with POI and 28 patients with POR, were included in the study. The patients in the POR group consisted of two different groups: diminished ovarian reserve (DOR) and premature ovarian failure (PMOF). Read More

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September 2020

'My relationships have changed because I've changed': biographical disruption, personal relationships and the formation of an early menopausal subjectivity.

Sociol Health Illn 2020 09 25;42(7):1516-1531. Epub 2020 Jun 25.

Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC, Australia.

Early menopause (EM) or premature ovarian insufficiency (POI) can disrupt gendered and age-related expectations associated with perceived 'normative' biographies for young adult women, with implications for subjectivity and relationships. While previous qualitative research has concentrated on the impacts of EM/POI on biography and sense of self, in this article, we examine the enmeshment of personal relationships with the formation of early menopausal subjectivities. Drawing on research exploring concepts of 'biographical disruption' and personal relationships, and theoretical work on social norms and subject formation, we present findings from a narrative thematic analysis of 25 interviews with women diagnosed with spontaneous or medically induced EM/POI. Read More

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September 2020

Anti-Müllerian hormone as a qualitative marker - or just quantity?

Curr Opin Obstet Gynecol 2020 06;32(3):219-226

Department of Obstetrics, Gynecology, and Reproductive Sciences, Section of Reproductive Endocrinology and Infertility, Yale University, New Haven, Connecticut, USA.

Purpose Of Review: In this review, we will summarize research looking into anti-Müllerian hormone (AMH) as a measure of oocyte quality.

Recent Findings: AMH is a key factor involved in embryogenesis but also in the development of early follicles. Owing to its relatively small inter and intracycle variability, it has become a widely used method of ovarian reserve testing. Read More

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Successful Spontaneous Pregnancy and Live Birth in a Woman With Premature Ovarian Insufficiency and 10 Years of Amenorrhea: A Case Report.

Authors:
Ying Gu Yan Xu

Front Med (Lausanne) 2020 7;7:18. Epub 2020 Feb 7.

Department of Gynaecology and Obstetrics, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Primary ovarian insufficiency (POI) is a devastating diagnosis for reproductive-aged women due to the associated infertility and other serious health consequences. Spontaneous pregnancy without hormone replacement therapy (HRT) and/or assisted reproductive technology (ART) rarely occurs in POI patients, particularly in those patients with long-term amenorrhea. On March 4, 2019, a 31-year-old Chinese POI patient visited our hospital for a spontaneous pregnancy after 10 years of amenorrhea and discontinuation of HRT 4 years prior. Read More

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February 2020

Ovarian Cortex Transplantation.

J Minim Invasive Gynecol 2020 Sep - Oct;27(6):1253. Epub 2019 Dec 12.

Assisted Reproductive Technique Unit (Dr. Pirrello), CMCO, University Hospital of Strasbourg.

Study Objective: To describe a laparoscopic technique for the transplantation of a cryopreserved ovarian cortex.

Design: Educational video.

Setting: University Hospital of Strasbourg, France. Read More

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January 2021

Ovarian reserve evaluation in a woman with 45,X/47,XXX mosaicism: A case report and a review of literature.

Mol Genet Genomic Med 2019 07 8;7(7):e00732. Epub 2019 May 8.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People's Republic of China.

Background: Turner syndrome (TS) is a common chromosomal disorder affecting approximately 1:2,500 live female births. Mosaic 47,XXX karyotype is found in 3%-4% of TS patients. TS phenotype in rare 45,X/47,XXX mosaicism patients is milder than in classic TS, however their ovarian function, especially in the mature age, has not been described in detail. Read More

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Sexuality in premature ovarian insufficiency.

Climacteric 2019 06 22;22(3):289-295. Epub 2019 Mar 22.

a Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, Obstetrics and Gynecology Unit, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences , University of Pavia , Pavia , Italy.

Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function. Early hormonal deprivation gives origin to symptomatic vulvovaginal atrophy and contributes to hypoactive sexual desire disorder modulating central and peripheral circuitries, which regulate sexual response. Read More

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Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure.

Curr Opin Obstet Gynecol 2019 06;31(3):156-162

Fundación IVI.

Purpose Of Review: We review the techniques recently tested in both animal models and humans to provide a state-of-the-art on adult stem cell ovarian transplant to achieve ovarian rejuvenation in patients with diminished ovarian reserves.

Recent Findings: As the firsts reports of spontaneous pregnancies achieved after bone marrow transplantation in oncologic women with primary ovarian insufficiency, increasing evidence supports the regenerative effects of stem cell-based therapies in the ovarian niche. Adult stem cells from several origins promote follicular development, increase ovarian local vascularization, increase follicle and stromal cell proliferation and reduce cell apoptosis and follicular atresia, although they do not modify embryo quality. Read More

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Consequences of premature ovarian insufficiency on women's sexual health.

Prz Menopauzalny 2018 Sep 30;17(3):127-130. Epub 2018 Sep 30.

Department of Gynaecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.

Premature ovarian insufficiency (POI) is defined by amenorrhoea and decreased serum levels of oestrogens associated with increased serum gonadotropins concentrations before the age of 40 years. Patients suffering from POI present with irregular menses, either secondary or (less common) primary amenorrhoea, and subfertility. POI affects approximately 1 in 100 women by the age 40 years and 0. Read More

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September 2018

Triptorelin for Fertility Preservation in Adolescents Treated With Chemotherapy for Cancer.

J Pediatr Hematol Oncol 2018 05;40(4):269-276

Pediatric Hematology and Oncology Unit, Department of Clinical and Experimental Medicine.

Background: Triptorelin, a gonadotropin releasing hormone analogue, can be administered to postpubertal female individuals with cancer who receive chemotherapy to obtain menstrual suppression and decrease the risk of hemorrhage caused by thrombocytopenia. Our goal was to assess whether triptorelin also has a protective role against the gonadotoxicity of chemotherapy.

Patients And Methods: This retrospective observational study includes all postmenarchal female patients who presented to our Unit from 2000 to 2015 and received chemotherapy for cancer. Read More

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TMCO1 is essential for ovarian follicle development by regulating ER Ca store of granulosa cells.

Cell Death Differ 2018 09 21;25(9):1686-1701. Epub 2018 Feb 21.

State Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 100101, Beijing, China.

TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER) transmembrane protein that actively prevents Ca stores from overfilling. To characterize its physiological function(s), we generated Tmco1 knockout (KO) mice. In addition to the main clinical features of human cerebrofaciothoracic (CFT) dysplasia spectrum, Tmco1 females manifest gradual loss of ovarian follicles, impaired ovarian follicle development, and subfertility with a phenotype analogous to the premature ovarian failure (POF) in women. Read More

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September 2018

Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency.

Authors:

Obstet Gynecol 2017 05;129(5):e134-e141

Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

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Committee Opinion No. 698 Summary: Hormone Therapy in Primary Ovarian Insufficiency.

Authors:

Obstet Gynecol 2017 May;129(5):963-964

Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

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Efficacy of ovarian tissue cryopreservation for fertility preservation: lessons learned from 545 cases.

Hum Reprod 2017 05;32(5):1046-1054

Gynecology Department, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCL) and Cliniques Universitaires Saint-Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium.

Study Question: How effective is ovarian tissue cryopreservation (OTC)?

Summary Answer: In our cohort of patients who underwent OTC, premature ovarian failure (POF) rates, return rates and pregnancy rates after autotransplantation were 31.5, 4.4 and 33%, respectively. Read More

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Differentiating the Causes of Spontaneous Rib Fracture After Breast Cancer.

Authors:
Susan R Harris

Clin Breast Cancer 2016 12 15;16(6):431-436. Epub 2016 Jul 15.

Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia. Electronic address:

Spontaneous rib fracture after treatment for primary breast cancer is not uncommon. Although metastatic disease accounts for about 30% of spontaneous rib fractures and should constitute the first line of diagnostic investigation, other possible contributors include primary osteoporosis or secondary osteoporosis resulting from cancer treatments. Chemotherapy-induced menopause, aromatase inhibitors, radiation therapy, and long-term bisphosphonate use can all contribute to bone fragility, including spontaneous rib fractures in the latter 3. Read More

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December 2016

Hormone Replacement Therapy Versus the Combined Oral Contraceptive Pill in Premature Ovarian Failure: A Randomized Controlled Trial of the Effects on Bone Mineral Density.

J Clin Endocrinol Metab 2016 09 24;101(9):3497-505. Epub 2016 Jun 24.

Menopause Research Unit (B.C., J.Ro., J.Ry.), McNair Centre, and Department of Nuclear Medicine (I.F.), Guy's Hospital, London, SE1 9RT, United Kingdom; and Department of Women's Health (P.T.S.), St Thomas' Hospital, London SE1 7EH, United Kingdom.

Context: Women with premature ovarian failure (POF) face many years of estrogen deficiency. One of the major consequences is bone loss. The optimal form of estrogen replacement is unknown and management is not evidence based. Read More

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September 2016

Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases.

Hum Reprod 2016 08 14;31(8):1913-25. Epub 2016 Jun 14.

Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia

Study Question: Can spontaneous premature ovarian failure (POF) patients derived from population-based biobanks reveal the association between copy number variations (CNVs) and POF?

Summary Answer: CNVs can hamper the functional capacity of ovaries by disrupting key genes and pathways essential for proper ovarian function.

What Is Known Already: POF is defined as the cessation of ovarian function before the age of 40 years. POF is a major reason for female infertility, although its cause remains largely unknown. Read More

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Autoimmune polyglandular syndrome type 3 (APS-3) among patients with premature ovarian insufficiency (POI).

Eur J Obstet Gynecol Reprod Biol 2016 Aug 20;203:61-5. Epub 2016 May 20.

Department of Gyneacological Endocrinology, Medical University of Warsaw, Ul. Karowa 2, 00-315 Warsaw, Poland.

Objectives: Autoimmune polyglandular syndrome type 3 - (APS-3), is defined as the coexistence of autoimmune thyroiditis with other non-ovarian autoimmune diseases without primary adrenal insufficiency. Additionally the definition of APS-3 also includes primary ovarian insufficiency (POI) coexistence with autoimmune thyroiditis. The main goal of that study is to assess the prevalence of APS-3 defined as coexistence of autoimmune thyroiditis with POI in population of 46 XX karyotype women with primary ovarian insufficiency (POI). Read More

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Premature ovarian insufficiency: the context of long-term effects.

J Endocrinol Invest 2016 Sep 18;39(9):983-90. Epub 2016 Apr 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, ul. Polna 33, Poznan, Poland.

Purpose: Premature ovarian insufficiency (POI) is defined as the cessation of the ovarian function before the age of 40 years. POI aetiology may be related to iatrogenic or endogenous factors and in many cases remains unclear. The aim of this review was to characterize the long-term consequences of POI. Read More

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September 2016

Analysis of FMR1 gene premutation and X chromosome cytogenetic abnormalities in 100 Tunisian patients presenting premature ovarian failure.

Ann Endocrinol (Paris) 2015 Dec 1;76(6):671-8. Epub 2015 Dec 1.

Laboratory of human cytogenetics, molecular genetics and reproductive biology, Farhat Hached university hospital, street Ibn El Jazzar, 4000 Sousse, Tunisia.

Objective: To evaluate the prevalence of FMR1 premutations and X chromosome cytogenetic abnormalities in a large cohort of Tunisian women with premature ovarian failure (POF).

Patients And Methods: The cohort consisted of 127 Tunisian women with POF referred by endocrinologists and gynecologists for genetic investigation in the context of idiopathic POF and altered hormonal profiles. Clinical information concerning the reproductive function in the family, previous hormonal measurements and/or possible fertility treatment were collected. Read More

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December 2015

Effect of primary ovarian insufficiency and early natural menopause on mortality: a meta-analysis.

Climacteric 2016 17;19(1):27-36. Epub 2015 Nov 17.

a Department of Maternal and Child Health, School of Public Health , Anhui Medical University , Hefei ;

Objective: The aim of this review was to systematically evaluate the associations of all-cause, cardiovascular and all-cancer mortality with primary ovarian insufficiency (POI) and early natural menopause (ENM).

Methods: Electronic databases for relevant studies were searched up to February 28, 2015. POI and ENM were usually defined as spontaneous menopause before age 40 years and at age 40-44 years, respectively. Read More

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October 2016

Gonadotropin-Releasing Hormone Agonist Cotreatment During Chemotherapy May Increase Pregnancy Rate in Survivors.

Oncologist 2015 Nov 13;20(11):1283-9. Epub 2015 Oct 13.

Department of Hematology, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: The use of gonadotropin-releasing hormone analogs (GnRHas) for fertility preservation is not unequivocally accepted. It is controversial whether GnRHa can increase the pregnancy rate in survivors.

Patients And Methods: This is a retrospective cohort study. Read More

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November 2015