318,021 results match your criteria Spontaneous Bacterial Peritonitis


[Introduction: The city of Villeurbanne has made the political choice to reduce social inequalities in health (SIH). The Public Health Department wanted to assess the health impact in the context of this project. The main objective was to analyse the links between urban development and health in order to identify the impact of the urban project on health and to make recommendations to reduce physical inactivity of children. Attention was focused on a neighbourhood of 6,000 inhabitants in the process of urban renewal. A high rate of adults on antidiabetic treatment was observed in this relatively deprived neighbourhood. School medicine also noted a high proportion of overweight children in schools in the neighbourhood, higher than in all schools of the city. The objective of this HIA was therefore to identify the impact of the renovation project on children’s mobility and to make recommendations in order to combat their physical inactivity by encouraging spontaneous physical activity.Methods: The selected determinants were grouped into four categories: outdoor environment, use of open spaces, adapted sports facilities/equipment, roads. The evaluation was based on analysis of urban planning documents, environmental analysis reports, ad hoc surveys, individual interviews with the various partners and target actors. A bibliographic review confirmed the positive or negative impacts of various aspects of the project on health.Results: Although some aspects of the project had a positive impact on the health of the inhabitants, others have a negative impact on children’s mobility, well-being and social capital. About 30 recommendations were proposed and prioritized according to their political support and their technical, economic and temporal feasibility.Discussion].

Sante Publique 2018 Sep;S2(HS2):63-67

Introduction: The city of Villeurbanne has made the political choice to reduce social inequalities in health (SIH). The Public Health Department wanted to assess the health impact in the context of this project. The main objective was to analyse the links between urban development and health in order to identify the impact of the urban project on health and to make recommendations to reduce physical inactivity of children. Read More

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September 2018

ABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.

Neurocrit Care 2018 Dec 13. Epub 2018 Dec 13.

Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background/purpose: Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH).

Methods: Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia University Irving Medical Center from 2009 to 2016 were evaluated. Read More

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December 2018
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Mitochondrial polymorphisms contribute to aging phenotypes in MNX mouse models.

Cancer Metastasis Rev 2018 Dec 14. Epub 2018 Dec 14.

Department of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.

Many inbred strains of mice develop spontaneous tumors as they age. Recent awareness of the impacts of mitochondrial DNA (mtDNA) on cancer and aging has inspired developing a mitochondrial-nuclear exchange (MNX) mouse model in which nuclear DNA is paired with mitochondrial genomes from other strains of mouse. MNX mice exhibit mtDNA influences on tumorigenicity and metastasis upon mating with transgenic mice. Read More

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December 2018

Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice.

Mol Ther Methods Clin Dev 2018 Dec 18;11:131-142. Epub 2018 Oct 18.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by high levels of pathogenic autoantibodies and tissue damage. Multiple studies showed that dendritic cell (DC) activation plays a critical role in SLE pathogenesis. Human alpha 1 antitrypsin (hAAT) is a serine proteinase inhibitor with potent anti-inflammatory and cytoprotective properties. Read More

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December 2018

Optimal Scene Time to Achieve Favorable Outcomes in Out-of-hospital Cardiac Arrest: How Long Is Too Long?

Cureus 2018 Oct 9;10(10):e3434. Epub 2018 Oct 9.

Internal Medicine, Brookdale University Hospital Medical Center, New York, USA.

Background Despite advances in resuscitation science and public health, out-of-hospital cardiac arrest (OOHCA) cases have an average survival rate of only 12% nationwide, compared to 24.8% of cases occurring in hospital. Many factors, including resuscitation interventions, contribute to positive patient outcomes and have, therefore, been studied in attempts to optimize emergency medical services (EMS) protocols to achieve higher rates of return of spontaneous circulation (ROSC) in the field. Read More

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October 2018

Intraductal papillary mucinous neoplasm complicated by a gastropancreatic fistula.

Radiol Case Rep 2019 Mar 7;14(3):320-323. Epub 2018 Dec 7.

University of Illinois at Chicago, Chicago, IL, USA.

One of the rare complications of low-grade pancreatic neoplasms is fistulization into nearby structures. This often does not present clinically, but is incidentally identified in patients who have been imaged serially to monitor the progression of the disease. In this report, we present an uncommon complication of an intraductal papillary mucinous neoplasm, which developed a spontaneous gastropancreatic fistula in a patient who was conservatively managed. Read More

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p53-Sensitive Epileptic Behavior and Inflammation in Hypomorphic Mice.

Front Genet 2018 27;9:581. Epub 2018 Nov 27.

Department of Biology and Biotechnology, Sapienza University of Rome, Rome, Italy.

Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Read More

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November 2018

Pupillary Measures of the Cognitive Effort in Auditory Novel Word Processing and Short-Term Retention.

Front Psychol 2018 27;9:2248. Epub 2018 Nov 27.

Department of Psychology, Universidad Complutense de Madrid, Madrid, Spain.

The use of the task-evoked pupillary responses (TEPRs) methodology is emerging in the psycholinguistics literature, as a sensitive, reliable and dynamic psychophysiological measure of the cognitive effort produced by various aspects of language processing. This preliminary study aimed to assess the functionality and effectiveness of a TEPRs design for measuring the cognitive effort required for the processing and spontaneous (non-explicitly prompted) short-term retention of novel phonological forms presented auditorily. Twenty-four young adult participants (aged 19-28 years, = 20. Read More

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November 2018
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Training Augmented Intelligent Capabilities for Pharmacovigilance: Applying Deep-learning Approaches to Individual Case Safety Report Processing.

Pharmaceut Med 2018 13;32(6):391-401. Epub 2018 Oct 13.

1Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901 USA.

Introduction: Regulations are increasing the scope of activities that fall under the remit of drug safety. Currently, individual case safety report (ICSR) collection and collation is done manually, requiring pharmacovigilance professionals to perform many transactional activities before data are available for assessment and aggregated analyses. For a biopharmaceutical company to meet its responsibilities to patients and regulatory bodies regarding the safe use and distribution of its products, improved business processes must be implemented to drive the industry forward in the best interest of patients globally. Read More

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October 2018

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.

Oncogene 2018 Dec 13. Epub 2018 Dec 13.

Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700, Fribourg, Switzerland.

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental evidence that ER breast cancer cells that survived high-dose Doxorubicin and Methotrexate based chemotherapies elicit a state of immunological dormancy. Read More

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December 2018

Virus-mediated export of chromosomal DNA in plants.

Nat Commun 2018 Dec 13;9(1):5308. Epub 2018 Dec 13.

Institute for Sustainable Plant Protection, National Research Council of Italy, Torino, 10135, Italy.

The propensity of viruses to acquire genetic material from relatives and possibly from infected hosts makes them excellent candidates as vectors for horizontal gene transfer. However, virus-mediated acquisition of host genetic material, as deduced from historical events, appears to be rare. Here, we report spontaneous and surprisingly efficient generation of hybrid virus/host DNA molecules in the form of minicircles during infection of Beta vulgaris by Beet curly top Iran virus (BCTIV), a single-stranded DNA virus. Read More

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December 2018

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.

Proc Natl Acad Sci U S A 2018 Dec 13. Epub 2018 Dec 13.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel;

Interleukin-1β (IL-1β) is abundant in the tumor microenvironment, where this cytokine can promote tumor growth, but also antitumor activities. We studied IL-1β during early tumor progression using a model of orthotopically introduced 4T1 breast cancer cells. Whereas there is tumor progression and spontaneous metastasis in wild-type (WT) mice, in IL-1β-deficient mice, tumors begin to grow but subsequently regress. Read More

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December 2018

Web System Prototype based on speech recognition to construct medical reports in Brazilian Portuguese.

Int J Med Inform 2019 Jan 26;121:39-52. Epub 2018 Oct 26.

Laboratory of Bioinformatics, Western Paraná State University, Presidente Tancredo Neves Avenue, 6731, ZIP code 85867-900, Foz do Iguaçu, Brazil; Service of Coloproctology, Faculty of Medical Sciences, University of Campinas, Tessália Vieira de Camargo Street, 126, ZIP code 13083-887, Campinas, Brazil. Electronic address:

The overall purpose of automatic speech recognition systems is to make possible the interaction between humans and electronic devices through speech. For example, the content captured from user's speech using a microphone can be transcribed into text. In general, such systems should be able to overcome adversities such as noise, communication channel variability, speaker's age and accent, speech speed, concurrent speeches from other speakers and spontaneous speech. Read More

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January 2019

Hypothesis: Spontaneous Advent of the Prebiotic Translation System via the Accumulation of L-Shaped RNA Elements.

Authors:
Ilana Agmon

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Institute for Advanced Studies in Theoretical Chemistry, Schulich Faculty of Chemistry-Technion-Israel Institute of Technology, Haifa 3200003, Israel.

The feasibility of self-assembly of a translation system from prebiotic random RNA chains is a question that is central to the ability to conceive life emerging by natural processes. The spontaneous materialization of a translation system would have required the autonomous formation of proto-transfer RNA (tRNA) and proto-ribosome molecules that are indispensable for translating an RNA chain into a polypeptide. Currently, the vestiges of a non-coded proto-ribosome, which could have only catalyzed the formation of a peptide bond between random amino acids, is consensually localized in the region encircling the peptidyl transferase center of the ribosomal large subunit. Read More

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December 2018

New Insight into Sperm Capacitation: A Novel Mechanism of 17β-Estradiol Signalling.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Laboratory of Reproductive Biology, Institute of Biotechnology CAS, v.v.i., BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.

17β-estradiol (estradiol) is a natural estrogen regulating reproduction including sperm and egg development, sperm maturation-called capacitation-and sperm⁻egg communication. High doses can increase germ cell apoptosis and decrease sperm count. Our aim was to answer the biological relevance of estradiol in sperm capacitation and its effect on motility and acrosome reaction to quantify its interaction with estrogen receptors and propose a model of estradiol action during capacitation using kinetic analysis. Read More

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December 2018

Synergistic Action of Sodium Selenite with some Antidepressants and Diazepam in Mice.

Pharmaceutics 2018 Dec 12;10(4). Epub 2018 Dec 12.

Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.

Background: The antidepressant and anxiolytic effects of selenium (Se) have been proven in many studies. This work was aimed at confirming these activities of its inorganic form-sodium selenite-and examining the possible synergy of action with antidepressants and diazepam.

Methods: The antidepressant- and anxiolytic-like activity of Se was assessed using forced swim tests (FSTs) and elevated plus-maze test (EPMs). Read More

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December 2018

Inhibitory Effect of Naphthoquinone-Tryptophan Hybrid towards Aggregation of PAP f39 Semen Amyloid.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

School of Molecular Microbiology & Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel.

PAP, a 39 amino acid peptide fragment, derived from the prostatic acid phosphatase secreted in human semen, forms amyloid fibrils and facilitates the attachment of retroviruses to host cells that results in the enhancement of viral infection. Therefore, the inhibition of amyloid formation by PAP (termed PAP f39) may likely reduce HIV transmission in AIDS. In this study, we show that the naphthoquinone tryptophan (NQTrp) hybrid molecule significantly inhibited PAP f39 aggregation in vitro in a dose-dependent manner as observed from the ThT assay, ANS assay, and transmission electron microscopy imaging. Read More

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December 2018

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13470

Department of Obstetrics and Gynecology.

In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20. Read More

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December 2018
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Transition of a Mallory-Weiss syndrome to a Boerhaave syndrome confirmed by anamnestic, necroscopic, and autopsy data: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13191

Department of Legal and Forensic Medicine, University of Genova, Genova.

Rationale: Spontaneous esophageal rupture (Boerhaave syndrome) is a rare, though frequently fatal, event. It is generally caused by a sudden increase in pressure inside the esophagus. In some cases, full-thickness perforations of the esophagus may develop from previous lesions that initially involve only the esophageal mucosa (Mallory-Weiss syndrome) and which, following further triggering events, give rise to a transmural lesion. Read More

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December 2018

Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma.

Carcinogenesis 2018 Dec 13. Epub 2018 Dec 13.

Tumor Angiogenesis Unit, Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.

Trabectedin is a marine-derived anti-neoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Since a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hypothesized that trabectedin might affect the growth and metastasis of this highly aggressive cancer. Read More

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December 2018

Calcium imaging, MEA recordings and Immunostaining images dataset of Neuron-Astrocyte Networks in Culture under the Effect of Norepinephrine.

Gigascience 2018 Dec 13. Epub 2018 Dec 13.

School of Electrical Engineering, Tel-Aviv University, Tel-Aviv, Israel.

Background: Monitoring the activity and morphology of Neuron-astrocyte networks in culture is powerful tool for studying dynamics, structure and communication in neuron-astrocyte networks independently or as a model of sub-brain network. These cultures are known to produce stereotypical patterns of activity e.g. Read More

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December 2018

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine.

Neuropsychobiology 2018 Dec 13:1-6. Epub 2018 Dec 13.

Department of Neurology, Dokkyo Medical University, Mibu,

Background: Photophobia is a common feature of migraine, which may involve abnormal cortical information processing. In electroencephalograms (EEG), photic driving is known as a reaction to visual stimulation. Both photophobia and photic driving response are present during light stimulation. Read More

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December 2018

Examining the link between reward and response inhibition in individuals with substance abuse tendencies.

Drug Alcohol Depend 2018 Dec 3;194:518-525. Epub 2018 Dec 3.

Department of Psychological and Brain Sciences, Texas A and M University, 400 Bizzell St., College Station, TX, 77843, USA.

Background: Substance use problems are often characterized by dysregulation in reward sensitivity and inhibitory control. In line with this representation, the goal of this investigation was to determine how substance abuse tendencies among university students affect incentivized response inhibition. Additionally, this study examined whether striatal dopamine moderates the impact of substance use on response inhibition performance. Read More

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December 2018

Spontaneous Nucleation of Stable Perfluorocarbon Emulsions for Ultrasound Contrast Agents.

Nano Lett 2018 Dec 13. Epub 2018 Dec 13.

Phase-change contrast agents are rapidly developing as an alternative to microbubbles for ultrasound imaging and therapy. These agents are synthesized and delivered as liquid droplets and vaporized locally to produce image contrast. They can be used like conventional microbubbles, but with the added benefit of reduced size and improved stability. Read More

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December 2018

Prevention and Management of Bleeding Episodes in Patients with Acquired Hemophilia A.

Authors:
Paul Knöbl

Drugs 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine 1, Division of Hematology and Hemostasis, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Acquired hemophilia A (AHA) is a rare autoimmune disease caused by autoantibodies inhibiting the function of coagulation factor VIII. It is characterized by spontaneous bleeding in patients with no previous family or personal history of bleeding. Although several large registries have collected clinical data on AHA, limited information is available on the optimal management of AHA because controlled clinical trials are lacking. Read More

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December 2018

Exploring the binding interaction between copper ions and Candida rugosa lipase.

Toxicol Res (Camb) 2018 Nov 17;7(6):1100-1107. Epub 2018 Sep 17.

School of Environmental Science and Engineering , Shandong University , China-America CRC for Environment & Health , Shandong Province , 72# Jimo Binhai Road , Qingdao , Shandong 266237 , P.R. China . Email: ; ; Tel: +86-531-88365489.

The wide range of applications of copper have caused widespread concern about its toxicity. However, few studies have reported the mechanism of the binding interaction between copper ions and digestive enzymes, which play an important role in physiological health and industrial production. In this study, the effects of copper ions on the conformation and activity of Candida rugosa lipase (CRL) were evaluated by isothermal titration calorimetry (ITC), multiple spectral techniques, molecular simulation and enzyme activity assays. Read More

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November 2018

Hypothermic treatment after computer-controlled compression in minipig: A preliminary report on the effect of epidural vs. direct spinal cord cooling.

Exp Ther Med 2018 Dec 5;16(6):4927-4942. Epub 2018 Oct 5.

Institute of Neurobiology, Biomedical Research Center, Slovak Academy of Sciences, 040 01 Košice, Slovakia.

The aim of the present study was to investigate the therapeutic efficacy of local hypothermia (beginning 30 min post-injury persisting for 5 h) on tissue preservation along the rostro-caudal axis of the spinal cord (3 cm cranially and caudally from the lesion site), and the prevention of injury-induced functional loss in a newly developed computer-controlled compression model in minipig (force of impact 18N at L3 level), which mimics severe spinal cord injury (SCI). Minipigs underwent SCI with two post-injury modifications (durotomy vs. intact dura mater) followed by hypothermia through a perfusion chamber with cold (epidural t≈15°C) saline, DMEM/F12 or enriched DMEM/F12 (SCI/durotomy group) and with room temperature (t≈24°C) saline (SCI-only group). Read More

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December 2018
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Long non-coding RNA HOTAIR overexpression improves premature ovarian failure by upregulating Notch-1 expression.

Authors:
Wei Zhao Liwei Dong

Exp Ther Med 2018 Dec 17;16(6):4791-4795. Epub 2018 Sep 17.

Department of Reproductive Medicine, People's Hospital of Dezhou, Dezhou, Shandong 253014, P.R. China.

The aim of the present study was to investigate the role of long non-coding (lnc)RNA HOTAIR in premature ovarian failure. A total of 69 women with spontaneous premature ovarian failure and 48 healthy women were enrolled in the present study. Ovarian tissues and blood samples were harvested from each participant. Read More

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December 2018

Identification and validation of differentially expressed proteins in serum of CSU patients with different duration of wheals using an iTRAQ labeling, 2D-LC-MS/MS.

Exp Ther Med 2018 Dec 1;16(6):4527-4536. Epub 2018 Oct 1.

Department of Dermatology, Pudong New Area People's Hospital, Shanghai 201299, P.R. China.

Chronic spontaneous urticaria (CSU) is one of the most common types of chronic urticaria (CU), with symptoms that recur easily, migrate and are refractory. It is unclear whether association between the differentiation of protein expression levels in the serum of CSU patients and the different duration of wheals exists. In the present study the samples were divided according to the duration of the wheals into group A (wheal duration <2 h) and group B (wheal duration 12-24 h). Read More

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December 2018

Evaluation of pregnancy outcomes in patients with multiple sclerosis after fingolimod exposure.

Ther Adv Neurol Disord 2018 3;11:1756286418804760. Epub 2018 Nov 3.

Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany.

Background And Methods: Limited data are available on the safety of fingolimod in pregnant women. We estimated the risk of adverse pregnancy outcomes in women with multiple sclerosis (MS) exposed to fingolimod either shortly before or during pregnancy in prospectively collected cases from clinical trials, observational studies, surveillance programs, and spontaneous reports.

Results: The prevalence of major malformations among live births does not appear to be significantly higher than those in the general population and the unexposed MS population. Read More

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November 2018

fMRI BOLD Correlates of EEG Independent Components: Spatial Correspondence With the Default Mode Network.

Front Hum Neurosci 2018 27;12:478. Epub 2018 Nov 27.

Bender Institute of Neuroimaging, Justus Liebig University Giessen, Giessen, Germany.

: We aimed to identify electroencephalographic (EEG) signal fluctuations within independent components (ICs) that correlate to spontaneous blood oxygenation level dependent (BOLD) activity in regions of the default mode network (DMN) during eyes-closed resting state. : We analyzed simultaneously acquired EEG and functional magnetic resonance imaging (fMRI) eyes-closed resting state data in a convenience sample of 30 participants. IC analysis (ICA) was used to decompose the EEG time-series and common ICs were identified using data-driven IC clustering across subjects. Read More

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November 2018

Astroglial Ca-Dependent Hyperexcitability Requires P2Y Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy.

Front Cell Neurosci 2018 23;12:446. Epub 2018 Nov 23.

Centro de Neurobiología y Plasticidad Cerebral CNPC, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca transients, which are sensitive to purinergic receptor antagonists but resistant to tetrodotoxin. The above suggests that alterations in astroglial Ca-dependent excitability observed in the epileptic tissue could arise from changes in astrocyte-to-astrocyte signaling, which is mainly mediated by purines in physiological and pathological conditions. In spite of that, how purinergic signaling contributes to astrocyte dysfunction in epilepsy remains unclear. Read More

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November 2018

Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.

Oncogene 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Division of Child and Adolescent Health, UNN - University Hospital of North-Norway, NO-9038, Tromsø, Norway.

Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous system, is frequently characterized by MYCN gene amplification and high expression of MYCN and c-MYC signature genes. Read More

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December 2018

A Rare Case of a Ruptured Metastatic Hepatic Lesion from a Jejunal Gastrointestinal Stromal Tumor (GIST) Treated by Arterial Embolization.

Am J Case Rep 2018 Dec 13;19:1480-1487. Epub 2018 Dec 13.

Department of General Surgery, Mount Lebanon Hospital, Beirut, Lebanon.

BACKGROUND Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal neoplasms. The spontaneous rupture of a jejunal GIST is very rare and spontaneous rupture of liver metastasis from an intestinal GIST is even rarer with only a few cases reported in the literature. CASE REPORT In this article, we reported a case of spontaneous rupture of a liver metastasis from a malignant jejunal GIST that presented with active tumoral bleeding, hypovolemic shock, and hemoperitoneum. Read More

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December 2018

A brainstem neural substrate for stopping locomotion.

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Dept. Neuroscience, Université de Montréal; Montréal, Québec, H3C 3J7; Canada.

Locomotion occurs sporadically and needs to be started, maintained, and stopped. The neural substrate underlying the activation of locomotion is partly known, but little is known about mechanisms involved in termination of locomotion. Recently, reticulospinal neurons (stop cells) were found to play a crucial role in stopping locomotion in the lamprey: their activation halts ongoing locomotion and their inactivation slows down the termination process. Read More

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December 2018

Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma.

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Eye Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Serotonin receptor agonists are neuroprotective in central nervous system (CNS) injury models. However, the neuroprotective functional implications and synaptic mechanism of 8-OH-DPAT, a serotonin receptor (5-HT1A) agonist, in an adult male Wistar rat model of chronic glaucoma model remain unknown. We found that ocular hypertension decreased 5-HT1A receptor expression in rat retinas, as the number of retinal ganglion cells (RGCs) was significantly reduced in rats with induced ocular hypertension relative to that in control retinas, and 8-OH-DPAT enhanced the RGC viability. Read More

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December 2018

Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response.

J Gen Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, University of Bern, Bern, Switzerland

During physical exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in protein kinase A (PKA)-mediated phosphorylation of the cardiac ryanodine receptor RyR2. PKA-dependent "hyperphosphorylation" of the RyR2 channel has been proposed as a major impairment that contributes to progression of heart failure. However, the sites of PKA phosphorylation and their phosphorylation status in cardiac diseases are not well defined. Read More

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December 2018

[Regulatory effect of hemichannels protein Pannexin-1 on P2X7 receptor activity in the lungs of mice with lung injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1071-1076

Department of Critical Care Medicine, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, Liaoning, China. Corresponding author: Zang Bin, Email:

Objective: To investigate the regulative effect of hemichannels protein Pannexin-1 on P2X7 receptor activation and caspase-1 mediated inflammatory response in the lungs of mice with lung injury.

Methods: Sixty male C57BL/6 mice were randomly divided into five groups with 12 mice in each group: sham operation group (Sham group), mechanical ventilation (MV) group, MV + low dose lipopolysaccharide (LPS) group (MLL group), MV + medium and high dose LPS group (MML group) and MV + high dose LPS group (MHL group). A "two-hit" lung injury model was reproduced by MV with high tidal volume combined with LPS injection in airway. Read More

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November 2018

[Value of the diaphragm movement index tested by ultrosonography for ventilation weaning].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1041-1045

Department of Emergency Medicine, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Hunan Key Laboratory of Critical and Critical Metabolomics, Changsha 410005, Hunan, China. Corresponding author: Han Xiaotong, Email:

Objective: To evaluate the diaphragm movement index of mechanical ventilation weaning patients by ultrosonography, and to explore its value for weaning.

Methods: Forty patients undergoing invasive mechanical ventilation for at least 48 hours admitted to emergency intensive care unit (EICU) of Hunan Provincial People's Hospital from September 2017 to February 2018 were enrolled. Low level pressure support ventilation (PSV) was used for spontaneous breathing test (SBT), and bedside M-mode ultrasonography was used to assess the diaphragm movement index of the patient within 1 hour of SBT, including the excursion of the diaphragm, diaphragmatic-rapid shallow breathing index (D-RSBI). Read More

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November 2018

[Effects between chest-compression-only cardiopulmonary resuscitation and standard cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: a Meta-analysis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1017-1023

Department of Emergency, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China (Liao XL, Tang H, Wang YZ, Wang M, Zhou MH); Department of Biomedical Engineering and Imaging, Army Medical University, Chongqing 400000, China (Chen BH). Corresponding author: Zhou Manhong, Email:

Objective: To comprehensively evaluate and compare the resuscitation efficacy of chest-compression-only cardiopulmonary resuscitation (CCPR) and standard cardiopulmonary resuscitation (SCPR) for patients with out-of-hospital cardiac arrest (OHCA).

Methods: Databases such as PubMed, Embase, Ovid, Cochrane Library, Wanfang, CNKI, VIP, CBM were searched from the date of their foundation to March 2nd 2018, and the studies on the difference of effects between CCPR and SCPR for patients with OHCA were retrieved. The outcomes included the return of spontaneous circulation (ROSC) rate, survival to hospital discharge, neurological function completion rate. Read More

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November 2018

Spontaneous Displacement of High Viscosity Micron Size Oil Droplets from a Curved Solid in Aqueous Solutions.

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

Spontaneous displacement of high viscosity (~103 Pas) micron size oil droplets from a curved solid in aqueous solutions was investigated. For high viscosity oils, the dynamic droplet shape was found to deviate significantly from a spherical cap shape due to the considerable viscous force in the oil phase. The displacement dynamics of high viscosity droplets were analyzed using molecular kinetic and hydrodynamic models. Read More

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December 2018

Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab treatment in patients with severe chronic spontaneous urticaria

Turk J Med Sci 2018 12 12;48(6):1255-1262. Epub 2018 Dec 12.

Department of Dermatology and Venereology, Health Sciences University, Kayseri Health Training and Research Center, Kayseri, Turkey

Background/aim: Spontaneous wheals and/or angioedema lasting longer than six weeks are described as chronic spontaneous urticaria (CSU). Omalizumab is used for the treatment of antihistamine-resistant CSU. The neutrophil–lymphocyte ratio (NLR), platelet– lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) are considered important indicators of inflammation and platelet activation in chronic diseases. Read More

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December 2018

Spontaneous Cure of Acute Hepatitis C.

Curr Health Sci J 2015 Oct-Dec;41(4):375-378. Epub 2015 Dec 22.

Department of Gastroenterology and Hepatology, Universitary Hospital Santa Maria, Lisbon.

The statistics proved that approximately 25% of the patients with acute HCV present with jaundice, and only 10-20% develop gastrointestinal symptoms. We present the case of a 58 year-old woman, with prior antecedents of arterial hypertension and diabetes mellitus since 25 years old, hypercholesterolemia and hypertriglyceridemia, psoriasis, epilepsy and depressive syndrome. She clinically presents asthenia, anorexia, itching, jaundice and choluria. Read More

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December 2015

Stroke recovery in rats after 24h-delayed, intramuscular neurotrophin-3 infusion.

Ann Neurol 2018 Dec 7. Epub 2018 Dec 7.

Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London, 16-18 Newcomen Street, London SE1 1UL, UK.

Objectives: Neurotrophin-3 (NT3) plays a key role in the development and function of locomotor circuits including descending serotonergic and corticospinal tract (CST) axons and afferents from muscle and skin. We have previously shown that gene therapy delivery of human NT3 into affected forelimb muscles improves sensorimotor recovery after stroke in adult and elderly rats. Here, to move towards the clinic, we tested the hypothesis that intramuscular infusion of NT3 protein could improve sensorimotor recovery after stroke. Read More

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December 2018

Nonsurgical Intervention in a Preeclamptic Patient with Spontaneous Spinal Epidural Hematoma.

Case Rep Obstet Gynecol 2018 7;2018:5879481. Epub 2018 Nov 7.

Department of Neurology, White Memorial Medical Center, Los Angeles, CA 90033, USA.

Background: Spontaneous epidural hematoma (SEH) is a rare finding in pregnancy, especially since most pregnant women do not have risk factors for developing SEH. The presence of epidural anesthesia can delay the diagnosis of SEH in pregnant patients. Immediate surgical decompression is the current standard of care for treating SEH. Read More

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November 2018

Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain.

Front Cell Neurosci 2018 22;12:453. Epub 2018 Nov 22.

Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Low back pain, a leading cause of disability, is commonly treated by epidural steroid injections that target the anti-inflammatory glucocorticoid receptor (GR). However, their efficacy has been controversial. All currently used epidural steroids also activate the pro-inflammatory mineralocorticoid receptor (MR) with significant potency. Read More

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November 2018

PDI Knockdown Inhibits Seizure Activity in Acute Seizure and Chronic Epilepsy Rat Models via -Nitrosylation-Independent Thiolation on NMDA Receptor.

Front Cell Neurosci 2018 22;12:438. Epub 2018 Nov 22.

Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, South Korea.

Redox modulation and -nitrosylation of cysteine residues are the post-translational modifications of -methyl-D-aspartate receptor (NMDAR) to regulate its functionality. Recently, we have reported that protein disulfide isomerase (PDI) reduces disulfide bond (S-S) to free thiol (-SH) on NMDAR. Since PDI is a modulator of -nitrosylation on various proteins, it is noteworthy whether PDI affects -nitrosylation of NMDAR in acute seizure and chronic epilepsy models. Read More

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November 2018

Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis.

Front Cell Neurosci 2018 14;12:407. Epub 2018 Nov 14.

Institut des Neurosciences de Montpellier (INM), Inserm, University of Montpellier, Montpellier, France.

During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents an efficient mechanism to shape the tonotopic organization along the ascending auditory pathway. Using calcium imaging, we show that the activity in the developing cochlea consists of calcium waves that propagate across the supporting and sensory cells. Read More

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November 2018

The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration.

Front Neurosci 2018 15;12:834. Epub 2018 Nov 15.

Chair and Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Retinal neurons are not able to undergo spontaneous regeneration in response to damage. A variety of stressors, i.e. Read More

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November 2018

Efficacy of a New Crosslinked Hyaluronan Gel in the Prevention of Intrauterine Adhesions.

JSLS 2018 Oct-Dec;22(4)

School of Medicine, Istanbul University, Department of Obstetrics and Gynecology, Istanbul, Turkey.

Background And Objectives: The authors sought to assess the effect of the use of a new crosslinked hyaluronan (NCH) gel on the prevention of intrauterine adhesions (IUAs) in women underwent curettage in the second trimester.

Methods: Between June 2016 and September 2017, 60 patients who underwent curettage for retained placental tissue after medically induced or spontaneous pregnancy loss in the second trimester were enrolled in the study. The patients were randomly assigned to 1 of 2 groups: Group 1 patients received curettage plus NCH gel (intervention group), and group 2 patients received curettage alone (control group). Read More

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December 2018