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Cerebrovasc Dis 2020 Jul 6:1-5. Epub 2020 Jul 6.

Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, New York, New York, USA,

Introduction: Evidence of visceral infarction is often found in patients with acute ischemic stroke. It remains uncertain whether there exists a relationship between visceral infarction and functional outcomes among patients with stroke.

Objective: The aim of this study was to evaluate whether evidence of visceral infarction is associated with functional outcomes among patients with stroke. Read More

Cureus 2020 May 28;12(5):e8338. Epub 2020 May 28.

Medicine and Pathology: Laboratory, University of Alberta, Edmonton, CAN.

Background Infective endocarditis (IE) is an uncommon disease with an involved interplay of clinical and surgical team management. We aimed to define diagnosis parameters and delineate in-hospital management in patients with IE admitted in a tertiary hospital of Southern Italian. Materials and methods Fifty-six consecutive patients (42 males, 14 females; age range: 34-85 years) admitted for IE in the Infectious Diseases, Cardiac Surgery, and Cardiology units, between January 2011 and August 2017, were enrolled. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):427-430

Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.

Infective endocarditis is a microbial infection of the endocardium and can easily affect heart valve.Its characteristic lesion is vegetation formation,and the shedding of vegetation results in arterial embolism and ischemic necrosis of corresponding tissues and organs.A case of infective endocarditis with multiple extracardiac complications was described in this article. Read More

CVIR Endovasc 2020 Jun 28;3(1):33. Epub 2020 Jun 28.

Interventional Radiology Unit - Monash Imaging, Monash Health, Melbourne, Australia.

Background: Visceral and renal artery aneurysms (VRAAs) are uncommon but are associated with a high mortality rate in the event of rupture. Endovascular treatment is now first line in many centres, but preservation of arterial flow may be difficult in unfavourable anatomy including wide necked aneurysms, parent artery tortuosity and proximity to arterial bifurcations. Endovascular stenting, and in particular flow-diversion, is used in neurovascular intervention to treat intracranial aneurysms but is less often utilised in the treatment of VRAAs. Read More

Can J Infect Dis Med Microbiol 2020 27;2020:6934149. Epub 2020 May 27.

Division of Infectious Disease, University of Colorado, Denver, CO, USA.

Splenic complications of acute infection include splenomegaly, splenic infarct, and splenic rupture. These complications are relatively rarely reported, and the aim of this research was to synthetize data on this topic according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using the PubMed database. In this review, we find that unlike other severe complications of babesiosis, splenic infarct and rupture occur in younger and immunocompetent patients, and they do not correlate with parasitemia level. Read More

BMJ Case Rep 2020 Jun 21;13(6). Epub 2020 Jun 21.

Department of Surgery, Westmead Hospital, Westmead, New South Wales, Australia.

A 62-year-old patient was admitted with an acute unprovoked portal vein thrombosis with splenic and mesenteric extension. His progress was complicated by progressive small bowel ischaemia and increasing clot burden despite systemic anticoagulation. This case report describes the use of catheter-directed thrombolysis via a transjugular intrahepatic portosystemic shunt, with the disease and its treatment complicated by a ruptured iatrogenic pseudoaneurysm, abdominal compartment syndrome and small bowel infarction necessitating extensive small bowel resection. Read More

Brain Behav 2020 Jun 7:e01660. Epub 2020 Jun 7.

Department of Neurology, Kumamoto Rosai Hospital, Kumamoto, Japan.

Background: Trousseau syndrome is a poor prognosis. We report a case of Trousseau syndrome treated by radical resection after endovascular treatment.

Case: A 59-year-old woman presented to our department reporting spontaneous dizziness and pain of the upper abdomen. Read More

High Alt Med Biol 2020 Jun 4. Epub 2020 Jun 4.

Department of Hematology, Army Hospital Research and Referral, New Delhi, India.

Ann Vasc Surg 2020 May 29. Epub 2020 May 29.

Department of Surgery, Emergency Department - Division of Emergency and Trauma, Surgery, Sapienza University of Rome, Rome, Italy.

Background: Splenic artery aneurysms (SAAs) are the most frequent visceral aneurysms, with a life-threatening risk in case of rupture. Our systematic review investigated the features of minimally invasive surgical approaches in vascular surgery for SAAs: robotic surgery and laparoscopy.

Methods: PubMed, EMBASE, and the Web of Science were systematically searched for robotic or laparoscopic surgery reports in SAA up to January 2020. Read More

Ann Hepatobiliary Pancreat Surg 2020 May;24(2):239-242

Department of Surgery, Armed Forces Capital Hospital, Seongnam, Korea.

Malaria shows various clinical manifestations from mild fever to death depending on the species. Among the complications, reports of malaria-associated splenic infarctions are rare. Here we present a case in which a man suffered from malaria-induced splenic infarction with serial follow-up. Read More

BJS Open 2020 May 20. Epub 2020 May 20.

Centre for Clinical Research Uppsala University, Västerås, Sweden.

Background: The aim of this study was to evaluate the diagnostic accuracy of unenhanced low-dose CT (LDCT) in acute colonic diverticulitis in comparison with contrast-enhanced standard-dose CT (SDCT).

Methods: All patients with clinically suspected diverticulitis who underwent LDCT followed by SDCT between January and October 2017 were evaluated prospectively. CT examinations were assessed for signs of diverticulitis, complications and other differential diagnoses by three independent radiologists (two consultants and one fourth-year resident) using SDCT as the reference method. Read More

Int J Mol Sci 2020 May 15;21(10). Epub 2020 May 15.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Excessive inflammation after myocardial infarction (MI) can promote infarct expansion and adverse left ventricular (LV) remodeling. L-4F, a mimetic peptide of apolipoprotein A-I (apoA-I), exhibits anti-inflammatory and anti-atherogenic properties; however, whether L-4F imparts beneficial effects after myocardial infarction (MI) is unknown. Here we demonstrate that L-4F suppresses the expansion of blood, splenic, and myocardial pro-inflammatory monocytes and macrophages in a mouse model of reperfused MI. Read More

Emerg Radiol 2020 May 18. Epub 2020 May 18.

Servicio de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

Wandering spleen (or ectopic spleen) is a rare anomaly resulting from hyperlaxity or even absence of the ligaments that hold the spleen in its anatomical position. Although more frequently a congenital condition, it can also be acquired. Torsion of the vascular pedicle is its potential main complication with subsequent development of splenic infarct. Read More

J Am Anim Hosp Assoc 2020 Jul/Aug;56(4):242-247. Epub 2020 May 15.

From the University of Bologna, Bologna, Italy.

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Surg Laparosc Endosc Percutan Tech 2020 May 8. Epub 2020 May 8.

Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University.

Background: Preservation of splenic vessels can minimize the risks of splenic infarction and gastric varices in laparoscopic spleen preserving distal pancreatectomy. A well-established procedure would provide high splenic vessels and spleen preservation rate. This study evaluated the outcomes and depending factors of laparoscopic splenic vessels and spleen preservation distal pancreatectomy (LsvspDP) via inferior-posterior splenic vein approach. Read More

Iran J Vet Res 2020 ;21(1):65-69

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea.

Background: Splenic infarction (SI) is a rare clinical entity seldom encountered in veterinary medicine. Its most frequent causes include thromboembolic status, splenomegaly, and cardiac disease. Although thrombotic elements from the circulation provide the most common context for thromboembolic SIs, immune-mediated hemolytic anemia (IMHA) has not been reported as an underlying disease in canine SI. Read More

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):576-582

Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To study the pathological changes of the spleen in patients with COVID-19 and to analyze the relationship between the weakened immune system and splenic lesions. Postmortem needle autopsies from the spleen were carried out on 10 patients who died from COVID-19 in Wuhan. Routine hematoxylin and eosin (HE) staining was used to observe the pathological changes. Read More

Med Mal Infect 2020 Apr 18. Epub 2020 Apr 18.

Département de médecine interne, hôpital Saint-Camille, 94360 Bry-sur-Marne, France.

Proc (Bayl Univ Med Cent) 2020 Apr 30;33(2):239-240. Epub 2020 Jan 30.

Department of General Internal Medicine, University of MarylandBaltimoreMaryland.

Splenic infarctions have been reported in cirrhotic patients with comorbidities (e.g., primary biliary cirrhosis), but there is little to no mention of spontaneous splenic infarction in alcoholic hepatitis. Read More

Surg Case Rep 2020 Apr 19;6(1):75. Epub 2020 Apr 19.

Department of Surgery, Kumamoto Rosai Hospital, 1670 Takehara-machi, Yatsushiro, Kumamoto, 866-8533, Japan.

Background: Trousseau's syndrome is a cancer-associated thrombosis. Trousseau's syndrome with cholangiocarcinoma is a rare condition with poor prognosis.

Case Presentation: A 59-year-old female was admitted to our hospital with abdominal pain, headache, and nausea. Read More

J Vasc Surg 2020 Apr 4. Epub 2020 Apr 4.

Division of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: In thoracic endovascular aortic repair (TEVAR), covering the celiac artery (CA) is sometimes necessary to secure the distal seal. We report the outcomes of planned CA coverage in our experience with TEVAR.

Methods: Cases requiring CA coverage during TEVAR from October 2008 to September 2018 were retrospectively reviewed. Read More

Case Rep Cardiol 2020 19;2020:9802908. Epub 2020 Mar 19.

Department of Interventional Cardiology, Intercor, Hospital Santo Antonio, Sinop, Brazil.

Background: Splenic infarction is a rare clinical condition. It is generally attributed to hematologic, vascular, cardioembolic, and infectious diseases or trauma. . Read More

Diagn Interv Radiol 2020 Mar 25. Epub 2020 Mar 25.

Department of Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.

Purpose: We aimed to evaluate the utility of and complications associated with the double microcatheter technique for the treatment of wide-necked visceral and renal artery aneurysms (VRAAs).

Methods: Nine patients (mean age, 58 years; age range, 42-69 years; 4 men, 5 women) with wide-necked VRAAs who underwent treatment with the double microcatheter technique from January 2016 to July 2018 were included in the study. For all patients, anatomical features were confirmed using cone-beam computed tomography (CT) with rotational angiography. Read More

J Emerg Med 2020 Apr 20;58(4):e189-e192. Epub 2020 Mar 20.

Department of Radiology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.

Background: Wandering spleen is defined as the localization of the spleen in the lower parts of the abdomen or the pelvic region, rather than the left upper quadrant. The torsion of wandering spleen is a rare clinical condition.

Case Report: We evaluate a case diagnosed with torsion of wandering spleen and underwent splenectomy in our hospital and discuss it in light of the literature. Read More

Tech Vasc Interv Radiol 2020 Mar 11;23(1):100658. Epub 2020 Jan 11.

Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD. Electronic address:

Bariatric arterial embolization (BAE) is a novel technique that is investigated as an alternative, often supplementary, method for weight management. BAE reduces blood perfusion to the gastric fundus, and thus, reduces the production of appetite-inducing hormones. No randomized controlled trial has evaluated the efficacy of BAE to date. Read More

Cir Esp 2020 Mar 7. Epub 2020 Mar 7.

Hospital Regional Universitario de Málaga, Málaga, España.

Eur Heart J Case Rep 2020 Feb 10;4(1):1-5. Epub 2020 Feb 10.

3rd Medical Department of Cardiology and Intensive Care Medicine, Wilhelminenhospital, Montleartstrasse 37, A-1160 Vienna, Austria.

Background: Non-bacterial thrombotic endocarditis (NBTE) is a rare condition, usually observed in association with malignancy, lupus erythematosus, or antiphospholipid syndrome. Diagnosis of NBTE remains a challenge as patients are often asymptomatic up to their first thromboembolic event. While there is no randomized data available for the guidance of treatment in NBTE, effective anticoagulation remains the main focus in the management of affected patients. Read More

Cureus 2020 Jan 19;12(1):e6700. Epub 2020 Jan 19.

Internal Medicine, West Virginia University, Charelston, USA.

Viruses are long known to be leading causes of self-limiting infections. Infectious mononucleosis (IM) caused by the Epstein-Barr virus (EBV) is, however, no exception. The ailment is caused by a DNA virus belonging to the Herpesviridae family. Read More

Clin Rheumatol 2020 Jun 27;39(6):1929-1934. Epub 2020 Feb 27.

Faculty of Medicine, Department of Rheumatology, Izmir Katip Celebi University, Karabaglar, 35360, Izmir, Turkey.

Splenic involvement is rarely reported in patients with ANCA-associated vasculitides (AAVs), particularly in those with granulomatosis with polyangiitis (GPA) and is in fact considered to be underestimated. We aimed to investigate the frequency of splenic lesions-mainly infarction-and related factors in patients with AAVs. Patients with AAV whose abdominal or thoracic computed tomographies (CTs) were performed at or after diagnosis were included in the study. Read More

Int Angiol 2020 Feb 13. Epub 2020 Feb 13.

Unidad de Trombosis y Hemostasia, Servicio de Hematología, Hospital Universitario de Salamanca, Instituto de Investigaciones Biomedicas de Salamanca, Universidad de Salamanca, Salamanca, Spain.

Background: Splenic artery aneurysms are rare, potentially serious, and usually asymptomatic. Several methods are currently available to treat them, each with their own advantages and drawbacks. Therefore, its therapeutic paradigm has changed. Read More

J Med Case Rep 2020 Feb 13;14(1):29. Epub 2020 Feb 13.

Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal.

Background: Atrial myxoma remains a rare clinical entity with an incidence of surgically resected cases of 0.5-0.7 per million population and prevalence of < 5 per 10,000. Read More

Ann Med Surg (Lond) 2020 Feb 20;50:10-13. Epub 2019 Dec 20.

Department of Biomedical and Clinical Sciences, L. Sacco Hospital University of Milan, Italy.

Background: Wandering spleen (WS) is a rare clinical entity resulting from the absence or maldevelopment of the ligaments normally involved in the attachment of the spleen in its normal position. WS can be a cause of acute abdomen leading to different complications ranging from torsion of the vascular pedicle to spleen infarction. Often, in absence of symptoms, it is an occasional finding during radiological exams and surgery represents the gold standard in the management of this unusual condition. Read More

J Vasc Interv Radiol 2020 Jul 1;31(7):1118-1131.e6. Epub 2020 Feb 1.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, Illinois; Department of Medicine, Division of Hematology and Oncology, Northwestern University, Chicago, Illinois. Electronic address:

Partial splenic embolization is a common procedure that reduces thrombocytopenia in patients with hypersplenism. The present review evaluated the adverse event profile of partial splenic embolization detailed in 30 articles. Although the technical success rate of the procedure in these papers is high, many patients experienced postprocedural complications. Read More

Arch Rheumatol 2019 Dec 22;34(4):447-450. Epub 2019 Apr 22.

Department of Rheumatology, Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.

Cytomegalovirus infection, which can occur as a result of reactivation due to immunosuppressive treatment in patients with granulomatosis with polyangiitis, is a serious condition that should be kept in mind because of its fatal course. In this article, we report a 49-year-old male patient with a diagnosis of granulomatosis with polyangiitis who developed a life-threatening colonic ulcer due to cytomegalovirus colitis and a shrunken spleen with irregular contours that was detected on abdominal computed tomography. This is a rare case of cytomegalovirus disease in a patient with granulomatosis with polyangiitis and splenic necrosis. Read More

Curr Med Imaging Rev 2020 ;16(1):88-93

Department of Radiology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Karabaglar, Izmir, Turkey.

Background: Wandering spleen (WS) is a rare clinical condition which may cause fatal complication like torsion with subsequent infarction. Determination of splenic parenchyma viability is very important in deciding whether splenopexy rather than splenectomy is an option. Contrast- enhanced computed tomography (CECT) is important for the diagnosis of WS and assessment of the viability of spleen. Read More

Pediatr Surg Int 2020 Mar 25;36(3):365-371. Epub 2020 Jan 25.

Department of General Surgery, Capital Institute of Pediatrics, No. 2 Yabaolu Rd., Beijing, 100020, People's Republic of China.

Background: Total splenectomy is the most effective surgical treatment for hereditary spherocytosis (HS). Nevertheless, post-splenectomy sepsis and hypoimmunity can pose a great risk to children. Some alternative treatments have been proposed to avoid the post-splenectomy complications. Read More

BMJ Case Rep 2020 Jan 23;13(1). Epub 2020 Jan 23.

Department of Internal Medicine, Spaarne Gasthuis Medical Centre, Hoofddorp, The Netherlands

Clarkson's syndrome, also known as idiopathic systemic capillary leak syndrome, is characterised by vascular hyperpermeability resulting in intravascular hypovolaemia and shock. A clinician should consider the diagnosis if other causes of shock, for example, sepsis and anaphylaxis, are ruled out and concomitant hyperviscosity is not caused by a myeloproliferative disease. Here, we describe a patient presenting with severe plasma leakage and assumable blood hyperviscosity leading to splenic infarction, gastrointestinal ischaemia-reperfusion syndrome and transient dysarthria. Read More

Mol Metab 2020 01 16;31:138-149. Epub 2019 Nov 16.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Alabama, 35294, United States. Electronic address:

Objective: Recently, we observed that the specialized proresolving mediator (SPM) entity resolvin D1 activates lipoxin A/formyl peptide receptor 2 (ALX/FPR2), which facilitates cardiac healing and persistent inflammation is a hallmark of impaired cardiac repair in aging. Splenic leukocyte-directed SPMs are essential for the safe clearance of inflammation and cardiac repair after injury; however, the target of SPMs remains undefined in cardiac healing and repair.

Methods: To define the mechanistic basis of ALX/FPR2 as a resolvin D1 target, ALX/FPR2-null mice were examined extensively. Read More

Eur J Case Rep Intern Med 2019 10;6(12):001283. Epub 2019 Dec 10.

Fédération de Médecine Gériatrie Thérapeutique, Rouen, France.

Iatrogenic antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is not exceptional. Many cases of small vessel vasculitis induced by anti-thyroid drugs (ATD), mainly propylthiouracil (PTU), have been reported. We present a case of AAV related to another ATD: benzylthiouracil (BTU) and review the literature. Read More

Cureus 2019 Nov 14;11(11):e6151. Epub 2019 Nov 14.

Surgical Unit II, Benazir Bhutto Hospital, Rawalpindi Medical University, Rawalpindi, PAK.

An arterial thrombus affecting the descending aorta, celiac artery, and superior mesenteric artery at the same time, resulting in mesenteric ischemia and splenic infarction, is a very rare phenomenon. We report a case of a 35-year-old, unmarried female, gravida 0 para 0, who presented with abdominal pain, vomiting, and constipation for two days. Computed tomography (CT) scan showed thrombi in the descending aorta to the celiac axis and superior mesenteric artery with splenic infarction, bowel ischemia, hepatic portal venous air, and uterine fibroid. Read More

Int J Surg Case Rep 2020 13;66:265-269. Epub 2019 Dec 13.

Department of Gastric Surgery, Ulsan University School of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Introduction: Gastric remnant ischemia after laparoscopic distal gastrectomy (LDG) in gastric cancer patients is a very rare but life-threatening condition, especially when accompanied by a splenic infarction or unplanned splenectomy.

Presentation Of Case: A 72-year-old male with no comorbid diseases was diagnosed with a well-differentiated adenocarcinoma of the lower stomach and underwent LDG with D2 lymph node dissection. However, a splenic artery injury necessitated a splenectomy intra-operatively, and delta anastomosis was performed based on a clinically viable remnant stomach. Read More

European J Pediatr Surg Rep 2019 Jan 13;7(1):e114-e116. Epub 2019 Dec 13.

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Gastrosplenic fistula is a very rare entity, most commonly occurring as a distinctive complication of splenic or gastric malignancies, most notably diffuse large B cell lymphoma (DLBCL). Benign gastric ulcer, splenic abscess, and Crohn's disease have also been reported as possible causes. We report a nonmalignant case of 16-year-old male with a gastrosplenic fistula of unclear etiology. Read More

J Pediatr Hematol Oncol 2020 Jul;42(5):371-372

Second Department of Paediatrics, School of Medicine, "P. & A. Kyriakou" Children's Hospital, National and Kapodistrian University of Athens (NKUA).

Intern Med 2020 04 13;59(7):1013. Epub 2019 Dec 13.

Department of General Internal Medicine and Infectious Disease, Saitama Medical University International Medical Center, Japan.

J Thorac Cardiovasc Surg 2019 Nov 2. Epub 2019 Nov 2.

Department of Surgery, University of Virginia, Charlottesville, Va. Electronic address:

Objective: Acute hyperglycemia during myocardial infarction worsens outcomes in part by inflammatory mechanisms. Pulsed ultrasound has anti-inflammatory potential in bone healing and neuromodulation. We hypothesized that pulsed ultrasound would attenuate the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury via the cholinergic anti-inflammatory pathway. Read More

Int J Surg Case Rep 2020 30;66:122-125. Epub 2019 Nov 30.

Fundación Santa Fe de Bogotá, Carrera 7 No. 117 - 15, Bogotá, Colombia.

Introduction: Spontaneous splenic rupture is an atraumatic event that represents a rare and life-threatening acute complication in which the spleen is damaged producing internal hemorrhage in the abdominal cavity. Its association with hematologic malignancies, although a rare occurrence, has been previously described. Among this subset of patients, chronic myeloid leukemia is one of the main causes. Read More

Middle East J Dig Dis 2019 Oct 5;11(4):225-229. Epub 2019 Nov 5.

Department of Internal Medicine, Shahid Beheshti Medical University, Tehran, Iran.

Polycythemia vera (PV) is classified as a myeloproliferative disorder (MPD). Such patients are prone to both thrombotic and hemorrhagic events. Although gastrointestinal (GI) bleeding is not a prominent manifestation of PV, it would be life threatening and necessitating hospital admission and blood transfusion if it occurs. Read More

J Pain Res 2019 27;12:3215-3220. Epub 2019 Nov 27.

Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Ehlers-Danlos syndrome (EDS) type IV is characterized by thin skin with visible veins, easy bruising, characteristic facial features, arterial and digestive complications, as well as rupture of the gravid uterus. It has never been previously reported that trigeminal autonomic cephalalgias (TACs) could manifest as the only initial symptom of EDS type IV. Here, we report a case of a 27-year-old man who presented atypical headache like TACs stimulated by right internal carotid artery dissection. Read More

S D Med 2019 Oct;72(10):459-463

Avera Queen of Peace Hospital, Department of Radiology, Mitchell, South Dakota.

Wandering spleen, otherwise known as ectopic spleen, is a rare congenital or acquired condition, especially in pediatric patients, characterized by elongated splenic pedicle due to congenital or acquired laxity of suspensory splenic ligaments resulting in exaggerated splenic mobility that predisposes it to torsion and often to subsequent infarction. We present a case of a 1-year old Caucasian female who presented with acute abdomen showing infarcted ectopic spleen on imaging. Most patients with infarcted spleen require surgery as the standard intervention. Read More

Transl Stroke Res 2020 Aug 3;11(4):831-836. Epub 2019 Dec 3.

Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.

Recognizing that the pathologic progression of stroke is closely associated with aberrant immune responses, in particular the activation of peripheral leukocytes, namely T cells, we hypothesized that finding a treatment designed to inhibit neuroantigen-specific T cells and block cytotoxic monocytes and macrophages may render therapeutic effects in stroke. We previously reported that subcutaneous administration of partial MHC class II constructs promote behavioral and histological effects in stroke mice by centrally promoting a protective M2 macrophage/microglia phenotype in the CNS and peripherally reversing stroke-associated splenic atrophy. Here, we employed a second species using adult Sprague-Dawley rats exposed to the middle cerebral artery occlusion stroke model and observed similar therapeutic effects with a mouse partial MHC class II construct called DRmQ, as evidenced by reductions in stroke-induced motor deficits, infarcts, and peri-infarct cell loss and neuroinflammation. Read More