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J Thromb Thrombolysis 2022 Jun 27. Epub 2022 Jun 27.

Department of Radiology, Radiologist, Thoracic Imaging, Jessa Hospital, Hasselt, Belgium.

The recreatinal use of nitrous oxide has become more common in recent years, especially in adolescents and young adults. It has been mainly associated with medical conditions like megaloblastic anemia and (myelo)neuropathy. We report on the thromboembolic complications, a less known side effect, associated with recreational inhalation of nitrous oxide. Read More

Ochsner J 2022 ;22(2):188-191

Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Essential thrombocythemia is a chronic myeloproliferative neoplasm characterized by thrombotic and hemorrhagic complications. Essential thrombocythemia can be considered a risk factor for thrombotic events. A 34-year-old female presented with sudden onset of abdominal pain from splenic infarction for which she underwent splenectomy. Read More

Circ Heart Fail 2022 Jun 22:CIRCHEARTFAILURE121008997. Epub 2022 Jun 22.

Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus. (R.R., V.K., S.G., O.B.-B., M.S.S., R.J.G., S.S.B.).

Background: CD4 T cells temporally transition from protective to pathological during ischemic heart failure (HF; 8 weeks postmyocardial infarction). Cellular mechanisms mediating this shift are unknown.

Methods: RNA-sequencing of cardiac CD4 T cells and flow cytometric analysis of immune cells was conducted. Read More

J Community Hosp Intern Med Perspect 2022 31;12(1):83-88. Epub 2022 Jan 31.

New York Cancer and Blood Specialists, Patchogue, USA.

Background: Neuroendocrine neoplasms (NENs) comprise a wide-ranging group of abnormal neoplasms with atypical presentations, from primary localized disease to extensive metastasis, reaching the bone and brain. The NENs are divided into two major groups: neuroendocrine tumors (NETs), which are well-differentiated tumors of any grade, and neuroendocrine carcinomas (NECs), which are poorly differentiated, high-grade cancers with a high risk of morbidity and mortality. The challenge of diagnosing NENs early, particularly prior to metastasis, highlights the importance of further studying these diseases. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221103384

Department of Pulmonary and Critical Care, Thomas Jefferson University, Philadelphia, PA, USA.

Splenic infarction is an uncommon cause of abdominal pain. In this article, we present a case of isolated splenic infarction presenting with severe abdominal pain, nausea, and with associated generalized weakness. Computed tomography (CT) abdomen and pelvis with contrast revealed multiple splenic infarctions of the entire lower pole with occlusion of the branch splenic arteries, while CT abdomen without contrast was unremarkable. Read More

Front Cardiovasc Med 2022 24;9:879322. Epub 2022 May 24.

Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Acute renal and splenic infarctions are an uncommon condition that can result from obstruction or decrease of renal and splenic arterial flow. We described a 73-year-old woman who presented with right flank pain and nocturnal dyspnea. The computed tomography (CT) scan with intravenous contrast showed multiple infarcts in both bilateral kidneys and spleen. Read More

J Minim Access Surg 2022 May 27. Epub 2022 May 27.

Department of Gastroenterological Surgery II, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Splenic infarction (SI) following gastrectomy is common; severe complications related to SI, such as splenic haemorrhage, abscess formation or rupture, can be fatal. To overcome these problems, we performed real-time vessel navigation using indocyanine green (ICG) fluorescence during robotic distal gastrectomy (RDG). The aim of study is to report the efficacy of robotic real-time vessel navigation for lymph node dissection (LND) along left gastroepiploic vessels (LGEVs). Read More

Cureus 2022 Apr 26;14(4):e24491. Epub 2022 Apr 26.

Emergency Medicine, Envision Physician Services, Plantation, USA.

We present a case of a 66-year-old male with a past history of newly diagnosed non-Hodgkin lymphoma, diabetes, and recent surgical splenectomy secondary to splenic infarct who presented to the Emergency Department (ED) with several nonspecific symptoms that were consistent with tumor lysis syndrome. This case report discusses the clinical presentation, diagnosis, and management of spontaneous tumor lysis syndrome. Read More

Front Cardiovasc Med 2022 13;9:882817. Epub 2022 May 13.

Department of Rheumatology, Affiliated Hangzhou First People's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Erdheim-Chester disease (ECD) is a rare disease that affects multiple systems and is characterized by non-Langerhans cell histiocytosis. Classic clinical signs include long bone infiltration, central nervous system involvement, diabetes insipidus, and sheathing of the entire aorta. However, thrombosis is not recognized as a typical cardiac manifestation of ECD. Read More

Life (Basel) 2022 May 1;12(5). Epub 2022 May 1.

Department for Innate Immunity and Tolerance, Institute of Transfusion Medicine and Immunology, University of Heidelberg, 1-3 Theodor-Kutzer Ufer, 68167 Mannheim, Germany.

Myocardial ischemia triggers neurohumoral activation of the cardiosplenic axis. In rodents, adverse outcomes occur upon prolonged entrance of mononuclear cells from the spleen into myocardial tissue. The purpose of this study is to assess the features of spleen structure in patients with fatal myocardial infarction (MI), the dynamics of macrophage infiltration of the spleen and its relationship with cardiac macrophage infiltration and unfavorable outcomes. Read More

Int J Surg 2022 Jul 20;103:106686. Epub 2022 May 20.

Department of Pancreatic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China. Electronic address:

Background: Spleen-preserving distal pancreatectomy is widely used to remove benign or low-grade malignant neoplasms located in the pancreatic body and tail. Both splenic vessels preserving (SVP-DP) and splenic vessels ligating (Warshaw technique [WT]) distal pancreatectomy are safe and effective methods but which technique is superior remains controversial. Thus, this study aimed to evaluate the clinical outcomes of patients who underwent both methods. Read More

IDCases 2022 18;28:e01509. Epub 2022 May 18.

Department of Hematology and Oncology, Pikeville Medical Center, Pikeville, KY 41501, USA.

The Coronavirus Disease 2019 (COVID-19) pandemic has rapidly progressed, resulting in significant global morbidity and mortality. Predominantly affecting the respiratory tract, it has been found to be associated with extrapulmonary manifestations such as coagulopathies. We hereby report a case of an elderly man with no predisposing risk factors or history of hypercoagulable disorder who presented with acute onset abdominal pain and was diagnosed with portal vein thrombosis and splenic infarct two weeks following mild COVID-19. Read More

Case Rep Pediatr 2022 13;2022:7890566. Epub 2022 May 13.

Riley Hospital for Children, Indianapolis, IN, USA.

Catastrophic antiphospholipid syndrome (CAPS) is an infrequent but feared life-threatening complication of antiphospholipid syndrome (APS). CAPS is characterized by the rapid development of numerous thromboses across multiple organs resulting in multiorgan failure. It is rare but well-documented in the adult population. Read More

J Belg Soc Radiol 2022 29;106(1):32. Epub 2022 Apr 29.

Ibn Sina Teaching hospital, MA.

Splenic infarction is an extremely rare presentation of median arcuate ligament syndrome that requires a good analysis of celiac axis on computed tomography angiography in other to make a proper diagnosis and management. Read More

Case Rep Transplant 2022 5;2022:6209300. Epub 2022 May 5.

Saint Louis University, St. Louis MO 63108, USA.

Background: Catastrophic antiphospholipid syndrome (CAPS) is an autoimmune thrombogenic disorder of small and large vessels caused by autoantibodies against phospholipids and phospholipid-binding proteins. This severe form of antiphospholipid syndrome (APS) presents clinically with simultaneous life-threatening multiorgan thrombosis and the presence of two or more persistent antiphospholipid antibodies (APL) confirmed on testing 12 weeks apart. . Read More

Radiol Case Rep 2022 Jul 6;17(7):2373-2377. Epub 2022 May 6.

Jenin Government Hospital, Palestinian Ministry of Health, Jenin, Palestine.

Polysplenia Syndrome is a rare condition that refers to the presence of 2 or more spleens in association with other thoracoabdominal abnormalities. Here, we report a case of a 13-year-old girl who presented with acute lower abdominal pain and was diagnosed with polysplenia syndrome after obtaining a CT scan of her chest, abdomen and pelvis. Diagnostic imaging also revealed the presence of a wandering spleen hanging in the lower abdomen and upper pelvic cavity and showing signs of infarction. Read More

Intern Med 2022 May 7. Epub 2022 May 7.

Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University College of Medicine, Korea.

Objective We retrospectively analyzed the prevalence and clinical features of splenic infarctions in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph MPNs). Patients Patients diagnosed with essential thrombocythemia (ET), polycythemia vera (PV), prefibrotic/early primary myelofibrosis (pre-PMF), or PMF from January 1996 to October 2020 in Chungnam National University Hospital, Daejeon, Korea, were reviewed. Results A total of 347 patients (143 ET, 129 PV, 44 pre-PMF, and 31 PMF patients; 201 men and 146 women) with a median age of 64 (range 15-91) years old were followed up for a median of 4. Read More

Cureus 2022 Apr 1;14(4):e23724. Epub 2022 Apr 1.

Internal Medicine, Manipal College of Medical Sciences, Pokhara, NPL.

Hepatic infarction is uncommon due to the dual blood supply from the hepatic artery and portal vein. The majority of the cases are caused following liver transplant or hepatobiliary surgery, hepatic artery occlusion, or shock. Hepatic infarction is a rare complication of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. Read More

Case Rep Surg 2022 22;2022:8696492. Epub 2022 Apr 22.

Department of General and Endocrine Surgery, Pitié Salpêtrière Hospital, APHP, Sorbonne University, 47-83 Boulevard de l'Hôpital, Paris, France.

Introduction: A wandering spleen is a rare anatomical condition characterized by a free-floating splenic tissue that is not located in its normal position in the left upper quadrant. This condition is usually asymptomatic but can also manifest itself with volvulus of the spleen and consequent infarction and necrosis of the parenchyma, requiring an urgent surgical management. Additionally, a wandering spleen can be associated with other contemporaneous anatomical anomalies. Read More

Radiol Case Rep 2022 Jun 15;17(6):2167-2169. Epub 2022 Apr 15.

Emergency Radiology Division, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy of Casablanca, 1, quartiers des hôpitaux, Casablanca, Morocco; 20100.

Ectopic spleen is a rare clinical entity characterized by splenic hypermobility which may be congenital or acquired. The spleen may be migrated to different positions in the peritoneum. The main complication is pedicular torsion with splenic volvulus, presenting as an emergency abdominal surgery. Read More

Cureus 2022 Mar 22;14(3):e23404. Epub 2022 Mar 22.

General and Colorectal Surgery, University of New South Wales, St. Vincent's Hospital, Sydney, AUS.

Splenic infarction associated with acute cytomegalovirus infection (CMV) in immunocompetent patients was initially described as a very rare occurrence but has been reported in recent years with increasing frequency. Many cases undergo multiple investigations only to leave acute CMV as the likely cause. There is a risk of splenic rupture and, although this complication is rare, fatalities have occurred. Read More

Radiol Case Rep 2022 Jun 12;17(6):2085-2091. Epub 2022 Apr 12.

Department of Vascular Surgery, St. Luke's University Health Network, Bethlehem, PA, USA.

Spontaneous isolated celiac artery dissection is considered an uncommon clinical condition. Rarer still is spontaneous isolated celiac and splenic artery dissection, with a total of 42 reported cases. There is no known definitive cause of visceral artery dissections, but risk factors include male sex, age in 5th or 6th decade, hypertension, and connective tissue disorders. Read More

J Surg Res 2022 Sep 20;277:44-49. Epub 2022 Apr 20.

Department of Surgery, Wright State University, Dayton, Ohio.

Introduction: Splenic artery embolization (SAE) is a routinely used adjunct in the nonoperative management (NOM) of blunt splenic injury (BSI). The purpose of this study was to evaluate the rate and type of adverse events that occur in patients undergoing SAE and to compare this with the previous data.

Methods: Patients who had SAE for BSI between 2011 and 2018 were identified. Read More

Anesth Essays Res 2021 Oct-Dec;15(4):341-347. Epub 2022 Mar 8.

Department of Anaesthesiology and Critical Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background: It has been more than a year since the whole world is struggling with COVID-19 pandemic and may experience resurgences in the near future. Along with severe pneumonia, this disease is notorious for extensive thromboembolic manifestations. That is why experts advocated aggressive anticoagulation as a part of the therapy since the beginning. Read More

BMC Surg 2022 Apr 9;22(1):136. Epub 2022 Apr 9.

Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.

Background: Hereditary spherocytosis (HS) complicated by splenic infarction is very rare, and it is even rarer to develop splenic infarction after infectious mononucleosis (IM) as a result of Epstein-Barr virus (EBV) infection. Therefore, misdiagnosis or missed diagnosis is prone to occur.

Case Presentation: A 19-year-old Chinese female previously diagnosed with HS was admitted to our institution with persistent high fever and icterus. Read More

Cureus 2022 Feb 24;14(2):e22582. Epub 2022 Feb 24.

Medicine, King Faisal University, Al-Ahsa, SAU.

Nontraumatic splenic rupture and hematoma are rare in sickle cell disease. We present a case of a 22-year-old Saudi male with sickle cell disease. He presented to our hospital with a history of nontraumatic abdominal pain, hemodynamic instability, and abdominal tenderness, with a large mass extending to the umbilicus. Read More

Front Pharmacol 2022 15;13:850187. Epub 2022 Mar 15.

Modern Research Center for Traditional Chinese Medicine (TCM), Beijing University of Chinese Medicine, Beijing, China.

Preliminary clinical and basic researches have proved that Qishen granule (QSG) is an effective prescription for treating heart failure (HF) in China, with a characteristic of regulating the ratio of M1/M2 macrophage in the myocardium. However, the regulative mechanism of monocytes targeting the cardio-splenic axis has not been fully elucidated. This study aimed to investigate the effects and mechanism of QSG inhibiting the release of splenic monocytes and the recruitment of myocardial tissue both and . Read More

Radiol Case Rep 2022 May 27;17(5):1794-1797. Epub 2022 Mar 27.

Department of Radiology, Sabah Women & Children's Hospital, 88450 Kota Kinabalu Sabah.

Wandering spleen is an uncommon cause of acute abdomen in children. Diagnosis of this condition is challenging due to its non-specific symptoms, varying intensity and protracted history of presentation. Radiographs and ultrasound imaging provide rapid and reliable means to diagnose this condition without exposure to excessive radiation. Read More

Front Med (Lausanne) 2022 11;9:780828. Epub 2022 Mar 11.

Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Introduction: () is a rare species leading to infective endocarditis (IE) with a poor prognosis. We describe a previously healthy patient with mitral valve infective endocarditis caused by .

Case Report: A young man was admitted with intermittent fever. Read More

Sci Rep 2022 03 16;12(1):4542. Epub 2022 Mar 16.

The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, 1300 Morris Park Avenue Forchheimer G46B, Bronx, NY, 10461, USA.

Reliable tools for macrophage identification in mouse tissues are critical for studies investigating inflammatory and reparative responses. Transgenic reporter mice and anti-macrophage antibodies have been used as "specific pan-macrophage" markers in many studies; however, organ-specific patterns of expression and non-specific labeling of other cell types, such as fibroblasts, may limit their usefulness. Our study provides a systematic comparison of macrophage labeling patterns in normal and injured mouse tissues, using the CX3CR1 and CSF1R macrophage reporter lines and anti-macrophage antibodies. Read More