Search Our Scientific Publications & Authors

Eur Heart J Case Rep 2021 Apr 21;5(4):ytab120. Epub 2021 Apr 21.

Department of cardiology, Heart Centre OLVG, Oosterparkstraat 9, 1091 AC Amsterdam, the Netherlands.

Background: Non-bacterial thrombotic endocarditis (NBTE) is a rare form of endocarditis notably described in patients with advanced malignancy and auto-immune diseases. It is characterized by the formation of sterile, fibrin-containing vegetations on cardiac endothelium, in the absence of positive blood cultures. It is predominantly located on the mitral- and aortic valve (AV). Read More

Cureus 2021 May 7;13(5):e14887. Epub 2021 May 7.

Gastroenterology Department, West Suffolk NHS Foundation Trust, Bury St Edmunds, GBR.

Hypercoagulability is now a recognized complication of COVID-19 infection. Despite this, splenic infarction remains rare and is often found incidentally, radiologically, or at autopsy. We report a case of symptomatic splenic infarction with superimposed infection, secondary to COVID-19-induced hypercoagulability in a young patient with paradoxical emboli due to an undiagnosed patent foramen ovale (PFO). Read More

Arab J Gastroenterol 2021 Apr 6. Epub 2021 Apr 6.

Department of Radiology, Kanuni Sultan Süleyman Education and Training Hospital, University of Health Sciences, Istanbul, Turkey. Electronic address:

Splanchnic venous thrombosis is a rare type of venous thromboembolism, and its actual incidence is still unknown. Splenic infarction develops due to splenic vein (SV) thrombosis. Patients with COVID-19 may be exposed to a risk of thrombotic events, and the system affected at the highest level by coagulopathy is the respiratory system. Read More

Am J Case Rep 2021 Jun 4;22:e931060. Epub 2021 Jun 4.

Pathological Anatomy Section, Careggi University Hospital, Florence, Italy.

BACKGROUND Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by foamy histiocytes, Touton-like giant cells, and fibrosis, typically affecting the diaphyseal and metaphyseal region of the long bones but that can involve any organ or tissue. ECD is usually associated with the BRAF V600E mutation or with other molecular mutations inserted in the MAPK cascade. CASE REPORT We present the case of a 63-year-old man with a previous history of myocardial infarction who underwent an emergency splenectomy for splenic rupture after an accidental fall. Read More

Cureus 2021 Apr 25;13(4):e14678. Epub 2021 Apr 25.

Cardiology, Mohammed I University/Mohammed VI University Hospital, Oujda, MAR.

Introduction: The complications of infective endocarditis (IE) are frequent and severe. Our aim was to study the clinical and paraclinical profiles and prognosis of vascular complications, observed in a cardiology unit in Oujda, Morocco. Among 57 patients hospitalized for IE between 2015 and 2020 at the cardiology unit, 19 patients, or 33. Read More

Trauma Case Rep 2021 Jun 21;33:100479. Epub 2021 Apr 21.

General Surgery and Traumatology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

Hypercoagulability after trauma is a known entity. Following significant trauma, most guidelines advise anticoagulation treatment for venous thromboembolism (VTE) prophylaxis. VTE following minor trauma convoyed with arterial or systemic embolization dictate the need to search for uncommon source of thromboembolic complications. Read More

Bioact Mater 2021 Dec 3;6(12):4415-4429. Epub 2021 May 3.

Department of Anatomy, State Key Laboratory of Trauma, Burn and Combined Injury, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Army Medical University (Third Military Medical University), Chongqing, 400038, China.

Cell therapy has been a promising strategy for cardiac repair after myocardial infarction (MI), but a poor ischemic environment and low cell delivery efficiency remain significant challenges. The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI, but it is unclear whether it could be used for human pluripotent stem cell (hiPSC) cultivation and provide a proper microenvironment for cell grafts against the ischemic environment. Herein, we developed a splenic extracellular matrix derived thermoresponsive hydrogel (SpGel). Read More

BMJ Case Rep 2021 May 5;14(5). Epub 2021 May 5.

Respiratory Medicine and General Medicine, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.

Here, we present a case of a 43-year-old patient with a background of active intravenous drug use who was diagnosed with aortic valve endocarditis. This was complicated by extensive acute embolic stroke and acute splenic, renal and liver infarction. This case highlights the difficulties in managing infective endocarditis in intravenous drug users and the importance of a comprehensive approach, addressing both the intracardiac infection and the underlying issue of substance misuse, to ensure best patient outcomes. Read More

BMC Cardiovasc Disord 2021 Apr 27;21(1):215. Epub 2021 Apr 27.

Department of Gynecology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, ShangTang Road 158, Hangzhou, 310014, China.

Background: Myocardial ischemia-reperfusion injury (MIRI) is the main pathological manifestation of cardiovascular diseases such as myocardial infarction. The potential therapeutic effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) and the participation of regulatory T cells (Tregs) in MIRI remains to be defined.

Methods: We used the experimental acute MIRI that was induced in mice by left ascending coronary ischemia, which were subsequently randomized to receive immunoglobulin G (IgG) or anti-CD25 antibody PC61 with or without intravenously injected BM-MSCs. Read More

J Glob Infect Dis 2020 Oct-Dec;12(4):238-239. Epub 2020 Nov 30.

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Int J Surg Case Rep 2021 Apr 24;81:105842. Epub 2021 Mar 24.

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Jeddah, Saudi Arabia. Electronic address:

Introduction: A left ventricular thrombus is very rare in a patient with normal systolic function. We are reporting a case of left ventricular thrombus in a patient with an abnormal presentation and normal ejection fraction.

Presentation Of Case: A 57-year-old female patient presented with severe epigastric and central abdominal pain associated with nausea, vomiting, constipation, and a decrease in appetite. Read More

BMJ Case Rep 2021 Apr 21;14(4). Epub 2021 Apr 21.

Department of Pediatrics, Mercer University School of Medicine, Macon, Georgia, USA.

Gastroschisis is an uncommon congenital defect of the abdominal wall resulting in intestinal prolapse, most commonly associated with short gut syndrome or bowel obstruction. Wandering spleen, movement of the spleen due to the underdevelopment of splenic ligaments, has a prevalence of 0.25% and is asymptomatic in 15% of paediatric cases. Read More

Clin Imaging 2021 Apr 14;79:12-19. Epub 2021 Apr 14.

Diagnostic and Interventional Radiology Department, Alexandria Faculty of Medicine, Shamplion Street, Alexandria 21131, Egypt. Electronic address:

Purpose: To report imaging findings at computed tomography angiography (CTA) and venography (CTV) of the abdomen and pelvis in evaluation of hemorrhagic and thrombotic lesions in hospitalized patients with COVID-19.

Methods: In this retrospective observational study, patients admitted to a single tertiary care center from April 1 to July 20, 2020, who tested positive for SARS-CoV-2 and developed acute abdominal pain or decreasing hemoglobin levels over the course of hospitalization were included. Abdominal CTA/CTV imaging studies performed in these patients were reviewed, and acute hemorrhagic or thromboembolic findings were recorded. Read More

J Small Anim Pract 2021 Apr 8. Epub 2021 Apr 8.

Department of Clinical Sciences, Kansas State University, Manhattan, Kansas, USA.

A 4-year-old female spayed domestic ferret (Mustela putorius furo) presented with a history of vomiting over 24 hours. On physical examination, a significantly enlarged, firm spleen was palpated. Abdominal radiographs and abdominal ultrasound were suggestive of a splenic torsion or splenic infarction. Read More

Clin Pract 2021 Mar 2;11(1):162-166. Epub 2021 Mar 2.

Internal Medicine, Hospital São Francisco Xavier-Centro Hospitalar Lisboa Ocidental, 1449-005 Lisbon, Portugal.

is a rare agent of endocarditis and subacute presentation may delay the diagnosis. We present the case of a 41-year-old male who was admitted to the hospital for further investigation regarding a consumptive syndrome with microcytic anaemia. Past medical history included new-onset mitral insufficiency followed by an ischaemic stroke due to small vessel disease. Read More

Cureus 2021 Feb 24;13(2):e13540. Epub 2021 Feb 24.

Department of Gastroenterological Surgery, Tottori University, Faculty of Medicine, Yonago, JPN.

Background: Median arcuate ligament (MAL) syndrome (MALS), also known as celiac artery (CA) compression syndrome and Dunbar syndrome, occurs because of extraluminal compression of the CA root by the MAL, which is part of the diaphragm. In MALS, a malposition of the MAL compresses the CA and causes nonspecific symptoms, including epigastric pain after eating, weight loss, nausea, and vomiting and can sometimes cause visceral aneurysms. Typically, in MALS, various chronic ischemic symptoms and visceral aneurysms due to changes in arterial blood flow are observed; however, in acute-onset MALS, acute organ failure due to ischemic changes may be problematic. Read More

J Pharm Pharm Sci 2021 ;24:148-152

Department of Medical Oncology, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Imatinib has an important place as an adjuvant therapy as well as in the treatment of metastatic disease caused by gastrointestinal stromal tumor (GIST), which is one of the common mesenchymal tumors of the gastrointestinal tract. Imatinib is a tyrosine kinase inhibitor and is generally well tolerated. However, it can cause some serious adverse effects. Read More

J Cardiothorac Surg 2021 Mar 30;16(1):61. Epub 2021 Mar 30.

Department of Radiology, Affiliated Hospital of Southwest Medical University, Luzhou, 64600, Sichuan, China.

Background: To evaluate the role of multi-slice spiral computed tomography (MSCT) angiography in the diagnosis of spontaneous isolated visceral artery dissection (SIVAD).

Methods: Twenty-seven patients with abdominal SIVAD were included in the study. The MSCT scans of the patients were subjected to various post-processing techniques to visualize the visceral artery wall. Read More

IDCases 2021 20;24:e01062. Epub 2021 Mar 20.

Department of General Surgery, Hospital do Trabalhador, Av. Rep. Argentina, 4406 - Novo Mundo, Curitiba, Paraná, 81050-000, Brazil.

Introduction: Multiple studies suggest that SARS-CoV-2 infection is associated with a pro-thrombotic state and thrombotic events have been recorded in several organs and systems. We report a patient with no respiratory symptoms, presented with abdominal pain and an extensive splenic infarction after COVID-19.

Case Report: A 67 year-old man was admitted to the emergency department with a moderate, dull, left-sided abdominal pain. Read More

Case Rep Infect Dis 2021 12;2021:6623834. Epub 2021 Mar 12.

Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection is usually self-limited. It presents with fever, pharyngitis, fatigue, and cervical lymph node enlargement. It is common among adolescents and young adults. Read More

J Thromb Thrombolysis 2021 Mar 25. Epub 2021 Mar 25.

Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, 333 Cedar Street, PO Box 208028, New Haven, CT, 06520-8028, USA.

Cancer patients have a high risk of thromboembolic events including splenic infarct (SI). However, risk factors for SI in cancer patients are poorly understood, and the utility of systemic anticoagulation in such patients is uncertain. We performed a retrospective cohort study of all cancer patients with SI treated at Yale New Haven Hospital from 2008 to 2017. Read More

Rev Esp Enferm Dig 2021 Mar 25. Epub 2021 Mar 25.

Immunology Investigative Institute, University Hospital. Federal University of Sergipe, Brasil.

We report a case of a COVID-19 patient presenting fever, headache and dyspnea evolving with severe acute abdominal pain; contrasted computed tomography (CT) scan diagnosed splenic infarction. We emphasize the importance of seeking the identification of complications of SARS-CoV-2 infection, notably thromboembolic events, with the potential to reduce the morbidity and mortality of the disease. Studies on radiological aspects involving the spleen and splenic infarctions associated with COVID-19 are scarce. Read More

Curr Neuropharmacol 2021 Mar 15. Epub 2021 Mar 15.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning. China.

The immune response following acute stroke has received great attention. The spleen is an important immune organ, and more and more studies have shown that brain-spleen crosstalk after stroke plays an important role in its development and prognosis. There are many mechanisms of spleen activation after stroke, including activation of the sympathetic nervous system, the production of chemokines, and antigen presentation in the damaged brain. Read More

Scand J Surg 2021 Mar 16:14574969211000546. Epub 2021 Mar 16.

Department of Angiology and Vascular Surgery, Hospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central and NOVA Medical School, Lisboa, Portugal.

Background And Aims: There are increasing reports on case series on spontaneous isolated mesenteric artery dissection, that is, dissections of the superior mesenteric artery and celiac artery, mainly due to improved diagnostic capacity of high-resolution computed tomography angiography performed around the clock. A few case-control studies are now available, while randomized controlled trials are awaited.

Material And Methods: The present systematic review based on 97 original studies offers a comprehensive overview on risk factors, management, conservative therapy, morphological modeling of dissection, and prognosis. Read More

Ann R Coll Surg Engl 2021 Apr 8;103(4):e127-e130. Epub 2021 Mar 8.

Mansoura University, Mansoura, Egypt.

A wandering spleen is a very rare event characterised by the absence of the spleen in its anatomical position due to the hyperlaxity of its ligaments. We present a case of wandering spleen complicated by splenic vascular pedicle torsion, thrombosis and subsequent splenic infarction. Compression of the infarcted spleen on the rectosigmoid junction led to the development of a sigmoid volvulus, which presented as an acute large bowel obstruction. Read More

Cureus 2021 Feb 1;13(2):e13065. Epub 2021 Feb 1.

Hematology/Oncology, Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, USA.

A high incidence of thromboembolic events and coagulation parameter abnormalities are seen in cases of coronavirus disease 2019 (COVID-19). Both venous and arterial thrombosis, including arterial thrombosis in unusual sites, have been reported in COVID patients in recent literature. Herein, we report a case of a 67-year-old female patient with non-critical COVID-19 disease with an incidental finding of an asymptomatic splenic infarct. Read More

J Gastroenterol 2021 Apr 24;56(4):382-394. Epub 2021 Feb 24.

Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube-Yamaguchi, 7558505, Japan.

Background: This study aimed to investigate changes in the hepatic venous pressure gradient (HVPG) by partial splenic embolization (PSE) and to identify the determinants of a clinically meaningful postoperative HVPG reduction.

Methods: Sixty-eight patients with cirrhosis and hypersplenism who underwent PSE at our department between September 2007 and June 2020 were included. The HVPG was evaluated pre- and immediately post-PSE. Read More

Radiol Case Rep 2021 May 13;16(5):999-1004. Epub 2021 Feb 13.

Ascension Saint Michael's Hospital, Stevens Point, WI.

Multiple studies and reports have suggested that coronavirus disease-19 (COVID-19) promotes arterial and venous thrombotic events in multiple organ systems, although the mechanism leading to a hypercoagulable state is still unknown. Few cases of splenic infarction associated with COVID-19 have been reported, of which half were found incidentally upon autopsy. This may be due to a clinically silent presentation or the symptoms being wrongfully attributed to pain caused by the effects of COVID-19. Read More

TH Open 2021 Jan 16;5(1):e81-e83. Epub 2021 Feb 16.

Section of Pulmonary/Critical Care, Department of Medicine, MedStar Washington Hospital Center, Washington, District of Columbia, United States.

Indian J Crit Care Med 2021 Jan;25(1):100-103

Department of Pathology, Mumbai, Maharashtra, India.

Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular lesion. It is a very rare cause of splenic artery aneurysm (SAA). An 18-year-old girl presented with hematemesis, melena, pancytopenia, and splenomegaly. Read More