1,955 results match your criteria Splenic Infarct


Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil:lymphocyte ratio, leading to inflamed milieu in acute heart failure.

FASEB J 2019 Feb 15:fj201802477R. Epub 2019 Feb 15.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Calorie-dense obesogenic diet (OBD) is a prime risk factor for cardiovascular disease in aging. However, increasing age coupled with changes in the diet can affect the interaction of intestinal microbiota influencing the immune system, which can lead to chronic inflammation. How age and calorie-enriched OBD interact with microbial flora and impact leukocyte profiling is currently under investigated. Read More

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http://dx.doi.org/10.1096/fj.201802477RDOI Listing
February 2019

Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility.

PLoS One 2019 14;14(2):e0208301. Epub 2019 Feb 14.

Department of Cardiology, University of Bonn, Bonn, Germany.

Background: Clinical and experimental data give evidence that transplantation of stem and progenitor cells in myocardial infarction could be beneficial, although the underlying mechanism has remained elusive. Ventricular tachyarrhythmia is the most frequent and potentially lethal complication of myocardial infarction, but the impact of mono nuclear cells on the incidence of ventricular arrhythmia is still not clear.

Objective: We aimed to characterize the influence of splenic mononuclear cell populations on ventricular arrhythmia after myocardial infarction. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208301PLOS
February 2019

An Unusual Case of Large-Vessel Vasculitis.

Eur J Case Rep Intern Med 2018 26;5(7):000897. Epub 2018 Jul 26.

Department of Medicine (Rheumatology), Hamad Medical Corporation, Doha, Qatar.

We report the case of a previously healthy 35-year-old man who presented with severe abdominal pain, nausea, vomiting and subjective fever and was found to have acute kidney injury, haematuria, leukocytosis and elevated inflammatory markers. An abdominal CT scan showed lobar nephronia of the left kidney complicated by infarction. Subsequent MRI also revealed splenic infarction. Read More

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http://dx.doi.org/10.12890/2018_000897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346781PMC

Atraumatic Splenic Rupture after Myocardial Infarction.

Eur J Case Rep Intern Med 2018 24;5(4):000827. Epub 2018 Apr 24.

Doncaster Royal Infirmary, Doncaster, United Kingdom.

Atraumatic splenic rupture is a rare but potentially life-threatening event. It mostly happens when the spleen is already diseased; however, sometimes it can be drug induced in a previously normal spleen. Although anticoagulation has been attributed to spontaneous splenic rupture quite frequently, the role of dual antiplatelet therapy is underestimated. Read More

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http://dx.doi.org/10.12890/2018_000827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346757PMC

Splenic infarction induced by epstein-barr virus infection in a patient with sickle cell trait.

J Paediatr Child Health 2019 Feb;55(2):249-251

Department of Pediatrics, Van Eslander Cancer Centre, Grosse Pointe Woods, Michigan, United States.

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http://dx.doi.org/10.1111/jpc.14376DOI Listing
February 2019

Splenic Artery Aneurysms, A Rare Complication of Type 1 Gaucher Disease: Report of Five Cases.

J Clin Med 2019 Feb 8;8(2). Epub 2019 Feb 8.

Reference Centre of Lysosomal Diseases, University Hospital Beaujon, 100 Boulevard du Général Leclerc, 92110 Clichy, France.

Type 1 Gaucher disease is a rare genetic lysosomal disorder due to acid betaglucosidase deficiency. The main features are thrombocytopenia, anemia, hepatosplenomegaly and complex skeletal disease. Complications include pulmonary hypertension, cirrhosis and splenic infarction; comorbidities, such as autoimmune phenomena, B-cell malignancies and Parkinson disease also occur. Read More

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http://dx.doi.org/10.3390/jcm8020219DOI Listing
February 2019
2 Reads

Splenic infarction as a rare presentation of severe babesiosis.

IDCases 2019 23;15:e00491. Epub 2019 Jan 23.

Department of Medicine, St. Vincent's Medical Center, Bridgeport, CT; The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, United States.

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http://dx.doi.org/10.1016/j.idcr.2019.e00491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355617PMC
January 2019

Cone beam versus conventional computed tomography angiography volume measurement in partial splenic embolization.

Medicine (Baltimore) 2019 Feb;98(5):e14312

When performing partial splenic arterial embolization (PSE), it can be difficult to determine the embolization ratio based on 2-dimensional digital subtraction angiography (DSA) image diagnosis alone. Therefore, at our department, we conduct computed tomography (CT) imaging intraoperatively and postoperatively to determine whether the planned embolization has been achieved. In recent years, developments in interventional radiology devices have enabled diagnostic imaging using cone beam CT. Read More

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http://dx.doi.org/10.1097/MD.0000000000014312DOI Listing
February 2019

C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function.

Circulation 2019 Jan 30. Epub 2019 Jan 30.

Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Germany.

Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is controlled by C X-C motif chemokine ligand 12 (CXCL12) and its receptor, C-X-C motif chemokine receptor 4 (CXCR4). CXCR4 antagonists mobilize inflammatory cells and promote infarct repair, but the cellular mechanisms are unclear. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036053DOI Listing
January 2019
1 Read
14.430 Impact Factor

Pulmonary embolism with migrating thrombus through patent foramen ovale: A case for a mixed pharmacological and percutaneous management.

J Cardiol Cases 2019 Jan 27;19(1):19-21. Epub 2018 Sep 27.

Interventional Cardiology Unit, S. Ambrogio Cardio-Thoracic Center, Milan, Italy.

A 61-year-old man, admitted to our hospital for bilateral pulmonary embolism, complicated by right renal ischemia and multiple splenic infarcts due to a mobile thrombus entrapped in a patent foramen ovale, has been successfully treated with apixaban 5 mg twice daily followed by transcatheter patent foramen ovale closure. < Apixaban could be a therapeutic alternative to thrombolysis and surgery in patients with warfarin-resistant thrombus straddling in the patent foramen ovale (PFO). Furthermore, apixaban could be a simple and useful option to manage patients undergoing transcatheter PFO closure. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342615PMC
January 2019
1 Read

Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis.

Transfus Clin Biol 2019 Jan 10. Epub 2019 Jan 10.

Sickle Cell Institute Chhattisgarh, Forest Block-2, Jail Road, Raipur 492001, Chhattisgarh India. Electronic address:

Sickle cell disease (SCD) is considered as a vascular disease due to its chronic vascular manifestations such as leg ulcers, priapism, acute chest syndrome (ACS), stroke, retinopathy, renal insufficiency, pulmonary hypertension, avascular necrosis of the femoral head (AVNF) and splenic infarction. Emerging evidence has shown that the MTHFR 677C>T variant allele is associated with vascular complications (VC) in patients with SCD; however, results from individual studies are inconclusive. The aim of this meta-analysis is to evaluate the association between the MTHFR 677C>T polymorphism and the susceptibility for VC in SCD patients. Read More

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http://dx.doi.org/10.1016/j.tracli.2019.01.003DOI Listing
January 2019
1 Read

"Bright Band Sign" A Grayscale Ultrasound Finding in Hepatic Infarction.

J Ultrasound Med 2019 Jan 21. Epub 2019 Jan 21.

Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Hepatic infarction is infrequent due to the dual blood supply of the liver and the compensatory relationship between the hepatic artery and portal vein. Most cases occur in liver transplants due to vascular complications. Grayscale sonography combined with color and spectral wave Doppler can assess for vessel patency and parenchymal abnormalities. Read More

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http://dx.doi.org/10.1002/jum.14939DOI Listing
January 2019

Serum Troponin Level in Acute Ischemic Stroke Identifies Patients with Visceral Infarcts.

J Stroke Cerebrovasc Dis 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurology, the Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:

Background And Purpose: Patients with ischemic stroke of cardioembolic origin are at risk of visceral (renal or splenic) infarction. We hypothesized that serum troponin level at time of ischemic stroke would be associated with presence of visceral infarction.

Methods: Data were abstracted from a single center prospective stroke database over 18 months and included all patients with ischemic stroke who underwent contrast-enhanced computerized tomography (CT) of the abdomen and pelvis for clinical purposes within 1 year of stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057193000
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.004DOI Listing
January 2019
5 Reads

Non-traumatic splenic rupture secondary to haemorrhagic infarct in diffuse large B-cell lymphoma.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Radiology, Queen Mary Hospital, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1136/bcr-2018-229052DOI Listing
January 2019
3 Reads

Splenic Infarction in Acute Cytomegalovirus and Human Parvovirus Concomitant Infection.

Case Rep Infect Dis 2018 3;2018:7027656. Epub 2018 Dec 3.

Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, Japan.

We present a case report of a 35-year-old woman who had splenic infarction. She had persistent high fever, systemic joint pain, and abnormal liver function. She was diagnosed with cytomegalovirus and human parvovirus B19 concomitant infection. Read More

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http://dx.doi.org/10.1155/2018/7027656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304844PMC
December 2018
1 Read

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea.

Korean J Parasitol 2018 Dec 31;56(6):609-613. Epub 2018 Dec 31.

Department of Internal Medicine, Inha University School of Medicine, Incheon 22212, Korea.

Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
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http://dx.doi.org/10.3347/kjp.2018.56.6.609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327201PMC
December 2018
5 Reads

Splenic Infarction as Only Manifestation of Antiphospholipid Syndrome in a Patient With Rheumatoid Arthritis.

J Clin Rheumatol 2018 Dec 28. Epub 2018 Dec 28.

From the Department of Emergency and Organ Transpantations, Rheumatology Unit, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1097/RHU.0000000000000964DOI Listing
December 2018
2 Reads

You're the Flight Surgeon.

Authors:

Aerosp Med Hum Perform 2019 Jan;90(1):63-64

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http://dx.doi.org/10.3357/AMHP.5210.2019DOI Listing
January 2019

Vanishing spleen syndrome post right partial nephrectomy in a sicklemic patient.

Pan Afr Med J 2018 16;30:211. Epub 2018 Jul 16.

Division of Urology, Harlem Hospital Center, Columbia University, New York, NY, USA.

Splenic infarction after contralateral laparoscopic renal surgery has not, to our knowledge, been reported. The spleen is the most affected organ in sickle cell disease and the mechanism of auto infarction is thought to result from the crystallization of abnormal hemoglobin during periods of hypoxia or acidosis resulting in parenchymal ischemia and ultimately tissue necrosis. We report a case of 45 year old female with sickle cell disease who had an unremarkable spleen at the time of a laparoscopic right partial nephrectomy and was subsequently found to have marked diminution in her splenic volume. Read More

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http://www.panafrican-med-journal.com/content/article/30/211
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http://dx.doi.org/10.11604/pamj.2018.30.211.15454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294983PMC
January 2019
5 Reads

Mowat-Wilson Syndrome Presenting With Purpura Fulminans.

Pediatrics 2019 Jan;143(1)

Division of Pediatric Hospital Medicine, Advocate Children's Hospital, Park Ridge, Illinois.

Purpura fulminans is a rapidly progressive syndrome of intravascular thrombosis and hemorrhagic infarction of the skin. The most common infectious etiology is sepsis, and less commonly it has been documented as a complication of invasive In children who are otherwise healthy, splenic dysfunction is a significant predisposing factor for invasive pneumococcal infection. We present the case of a 10-month-old girl with a history of developmental delay, who developed an overwhelming infection complicated by purpura fulminans and was found to have previously undiagnosed Mowat-Wilson syndrome with anatomic asplenia. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-0922DOI Listing
January 2019
8 Reads

Canis Caveat (Beware of the Dog) - Septic Shock Due To Capnocytophaga Canimorsus Contracted From A Dog Bite

Ir Med J 2018 Dec 6;111(10):842. Epub 2018 Dec 6.

Department of Intensive Care Medicine, St. Vincent’s University Hospital

We describe the case of a 61-year-old immunocompetent male who developed septic shock and multiorgan failure due to Capnocytophaga canimorsus (C. canimorsus) bloodstream infection, sustained from a dog bite. Unusually, this patient developed acute liver failure and splenic infarction in addition to many of the better-known clinical sequelae of C. Read More

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December 2018

Renal and Splenic Infarction in a Patient with Familial Hypercholesterolemia and Previous Cerebral Infarction.

Am J Case Rep 2018 12 10;19:1463-1466. Epub 2018 Dec 10.

Department of Internal Medicine, Haga Teaching Hospital, Hague, Netherlands.

BACKGROUND This is a case report of a male patient who presented with a history of right flank pain based on renal infarction. Initially the symptoms were misdiagnosed as acute pyelonephritis. CASE REPORT A 47-year-old male with a history of familial hypercholesterolemia and cerebral infarction presented at the Emergency Department with a 3-day history of acute right-sided flank pain. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911990
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http://dx.doi.org/10.12659/AJCR.911990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298247PMC
December 2018
5 Reads

Splenic infarction due to cytomegalovirus infection in an immunocompetent patient.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Servicio de Medicina Interna, Hospital Garcia Orcoyen, Estella, Navarra, España.

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http://dx.doi.org/10.1016/j.medcli.2018.10.015DOI Listing
November 2018
7 Reads

Massive Splenic Infarction in a Child With Sickle Cell Disease on Chronic Transfusion Therapy.

J Pediatr Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Departments of Pediatrics.

Massive splenic infarction (MSI) is a rare complication of sickle cell disease, as the spleen generally atrophies within the first few years of life. We report a case of MSI in a 12-year-old boy with homozygous sickle cell anemia (Hb SS) whose chronic transfusion therapy resulted in hypersplenism. The occurrence of a complicated MSI in our patient should perhaps further encourage elective splenectomy in such patients, despite known potential perioperative complications and postsplenectomy risks of infection and thrombosis. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001356DOI Listing
November 2018
9 Reads

Infarct-Sparing Effect of Adenosine A2B Receptor Agonist Is Primarily Due to Its Action on Splenic Leukocytes Via a PI3K/Akt/IL-10 Pathway.

J Surg Res 2018 Dec 23;232:442-449. Epub 2018 Jul 23.

Department of Surgery, University of Virginia Health System, Charlottesville, Virginia. Electronic address:

Background: Adenosine A2B receptor (AAR) agonist reduces myocardial reperfusion injury by acting on inflammatory cells. Recently, a cardiosplenic axis was shown to mediate the myocardial postischemic reperfusion injury. This study aimed to explore whether the infarct-squaring effect of AAR agonist was primarily due to its action on splenic leukocytes. Read More

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http://dx.doi.org/10.1016/j.jss.2018.06.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251504PMC
December 2018
6 Reads

[Splenic infarction revealing infectious endocarditis in a pregnant woman: about a case and brief literature review].

Pan Afr Med J 2018 27;30:184. Epub 2018 Jun 27.

Service de Gynécologie-Obstétrique, Hôpital Militaire d'Instruction, Rabat, Maroc.

The diagnosis of splenic infarction is rarely reported in pregnant women. Current incidence of splenic infarction, especially during infectious endocardites as well as diagnostic methods used are poorly specified in the literature. We here report the case of a 26-year old woman with no particular previous history or cardiovascular risk factor who, at the end 14 weeks of amenorrhea, presented to the Emergency Department with febrile syndrome evolving over 10 days and abdominal pain of recent onset at the level of the left hypochondre. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.184.14262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235498PMC
December 2018
8 Reads

Ultrasonography of the pediatric spleen: a pictorial essay.

J Ultrasound 2018 Nov 16. Epub 2018 Nov 16.

Paediatric Radiology Department, "Federico II" University Hospital, Naples, Italy.

In infants and children, the spleen is involved in many pathological processes, whether those processes are isolated or related to systemic diseases. Pathology of the pediatric spleen includes congenital anomalies, splenomegaly, trauma, focal lesions, infarction, and tumors. Ultrasonography (US) is a widely available, fast, noninvasive imaging technique to assess the size, shape, and position of the spleen, as well as to define splenic echotexture. Read More

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http://link.springer.com/10.1007/s40477-018-0341-2
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http://dx.doi.org/10.1007/s40477-018-0341-2DOI Listing
November 2018
16 Reads

Splenic embolization for a giant splenic hemangioma in a child: a case report.

BMC Pediatr 2018 Nov 12;18(1):354. Epub 2018 Nov 12.

Department of Pediatrics, Chungbuk National University Hospital, Cheongju, Republic of Korea.

Background: Splenic hemangioma is the most common benign tumor of the spleen. However, it remains a rare medical condition in children. Although the natural course of splenic hemangioma is slow growth, treatment for large splenic hemangiomas has been recommended due to the risk of spontaneous rupture causing life-threating hemorrhage. Read More

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http://dx.doi.org/10.1186/s12887-018-1331-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233546PMC
November 2018
14 Reads

Laparoscopic splenic pseudocyst management using indocyanine green dye: An adjunct tool for better surgical outcome.

J Minim Access Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of General and Minimal Access Surgery and Robotic Surgery, Indraprastha Apollo Hospitals, New Delhi, India.

Splenic cysts are not so common in incidence. Only 800-850 cases have been reported till now in the literature. Splenic cysts can be further classified into parasitic and non-parasitic cysts. Read More

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http://dx.doi.org/10.4103/jmas.JMAS_156_18DOI Listing
November 2018
2 Reads

Thrombus on the inflow cannula of the HeartWare HVAD: an update.

Cardiovasc Pathol 2019 Jan - Feb;38:14-20. Epub 2018 Sep 15.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. Electronic address:

Background: The HeartWare HVAD (Medtronic, Minneapolis, MN) is a continuous-flow left ventricular assist device (LVAD) approved by the FDA in 2012 as a bridge to transplant in patients with end-stage left ventricular heart failure. The current inflow cannula has a smooth outer surface near the inflow edge and a sintered collar of titanium microspheres near the pump. A previous case series of HVAD patients bridged to transplant revealed thrombus on the outer surface of the inflow cannula in 8 of 8 patients, predominantly at the smooth-sintered interface, that was associated with a clinical stroke rate of 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183015
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http://dx.doi.org/10.1016/j.carpath.2018.09.002DOI Listing
September 2018
17 Reads

Simultaneous occurrence of five prothrombotic induced vaso-occlusive phenomena and focal nodular hyperplasia due to prolonged use of combined oral contraceptive pills.

BJR Case Rep 2018 15;4(2):20170070. Epub 2017 Dec 15.

M.P Shah Hospital, University of Nairobi, Nairobi, Kenya.

This is a rare case of a patient simultaneously presenting with five complications associated with the prolonged (5 years) use of combined oral contraceptives. The two main ingredients of combined oral contraceptives responsible for thromboembolism are estrogen (estradiol) and progestogen (progestin). Progestins are linked with occlusion of arteries while estrogens can induce both arterial and venous thrombosis. Read More

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http://dx.doi.org/10.1259/bjrcr.20170070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159115PMC
December 2017
2 Reads

Contrast-enhanced ultrasound in the evaluation of splenic injury healing time and grade.

Radiol Med 2018 Oct 25. Epub 2018 Oct 25.

SOD Radiologia Pediatrica e Specialistica, Azienda Ospedaliero Universitaria Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

Aims: To assess mean healing time of blunt spleen injuries managed nonoperatively using CEUS (contrast-enhanced ultrasound); to analyze whether spleen injury grade, subcapsular hematoma (SCH) presence, SCH grade and spleen infarct after spleen artery angioembolization could be related to healing time; and to evaluate CEUS sensitivity in diagnosing spleen injury and to assess CEUS performance in classifying spleen injury grade compared to CT.

Materials And Methods: After CT evaluation in the Emergency Department, 101 hemodynamic stable blunt spleen trauma patients (73 males; 28 females; mean age 46.4 years, range 18-92) underwent serial CEUS follow-up examinations at pre-established intervals (1, 3, 8, 15, 30, 60, 90 and 180 days after trauma), until spleen injury became no more identifiable. Read More

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http://dx.doi.org/10.1007/s11547-018-0954-8DOI Listing
October 2018
9 Reads

Vago-Splenic Axis in Signal Transduction of Remote Ischemic Preconditioning in Pigs and Rats.

Circ Res 2018 Oct;123(10):1152-1163

From the Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Germany (H.R.L., P.K., A.S., H.H., G.H.).

Rationale: The signal transduction of remote ischemic conditioning is still largely unknown.

Objective: Characterization of neurohumoral signal transfer and vago-splenic axis in remote ischemic preconditioning (RIPC).

Methods And Results: Anesthetized pigs were subjected to 60 minutes of coronary occlusion and 180 minutes of reperfusion (placebo+ischemia/reperfusion [PLA+I/R]). Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31385
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313859DOI Listing
October 2018
8 Reads

[Management of Visceral Artery Aneurysms with Preservation of Organ Perfusion: More Than Twenty Years Experience].

Zentralbl Chir 2018 Oct 24;143(5):516-525. Epub 2018 Oct 24.

Abteilung für Gefäßchirurgie, Universitätsklinikum Regensburg, Deutschland.

Background: Visceral artery aneurysms (VAA) are rare and often incidental findings. Indications for treatment are symptomatic patients, pseudoaneurysms and a true aneurysm of diameter of ≥ 2.5 cm for mesenteric arteries and ≥ 3 cm for renal artery aneurysms. Read More

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http://dx.doi.org/10.1055/a-0750-6016DOI Listing
October 2018
3 Reads

Left lower quadrant pain: an unlikely diagnosis in a case of acute abdomen.

J Community Hosp Intern Med Perspect 2018 15;8(5):296-299. Epub 2018 Oct 15.

Department of Medicine, Easton Hospital, Easton, PA, USA.

Splenic infarct is an incredibly rare diagnosis for abdominal pain. One study involving two hospitals over ten years describes only 0.0037% of all hospital admissions presenting with splenic infarction. Read More

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https://www.tandfonline.com/doi/full/10.1080/20009666.2018.1
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http://dx.doi.org/10.1080/20009666.2018.1517578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197027PMC
October 2018
9 Reads

Spontaneous Celiac Artery Dissection Presenting With Splenic Infarction: A Case Report.

Gastroenterology Res 2018 Oct 1;11(5):379-382. Epub 2018 Oct 1.

Department of Internal Medicine, Advocate Illinois Masonic Medical Center, 836 W Wellington Ave., Chicago, IL 60657, USA.

Spontaneous isolated celiac artery dissection (SICAD) is extremely rare. We herein report a case of a 43-year-old male with no known history of cardiovascular disease who presented to the emergency department (ED) with sudden onset severe epigastric abdominal pain without a known trigger. Abdominal computed tomography (CT) scan showed a focal dissection and irregular enhancement of the celiac trunk with associated splenic artery embolus and large splenic infarct. Read More

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http://dx.doi.org/10.14740/gr1065wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188032PMC
October 2018
1 Read

Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion.

J Neuroinflammation 2018 Oct 15;15(1):288. Epub 2018 Oct 15.

Department of Neurology, University of Kentucky, 741 S. Limestone BBSRB B457, Lexington, KY, 40536-0905, USA.

Background: The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation of antioxidant enzymes, promotes an anti-inflammatory phenotype in several types of immune cells. The goal of this study was to determine whether LIF treatment modulates the peripheral immune response after stroke. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1326-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190542PMC
October 2018
13 Reads

POEMS syndrome complicated with multiple ischemic vascular events: case report and review of literature.

Onco Targets Ther 2018 27;11:6271-6276. Epub 2018 Sep 27.

Department of Hematology, University Emergency Hospital Bucharest, Bucharest, Romania,

POEMS syndrome (acronym consisting of: polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is an uncommon disorder associated with an underlying plasma cell dyscrasia. There is no single specific test for POEMS, and due to its rarity and heterogeneity, patients are often mis- or underdiagnosed. Castleman disease (CD) is a rare lymphoproliferative disorder, closely related to POEMS syndrome; ~11%-30% of POEMS patients are associated with concomitant CD. Read More

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https://www.dovepress.com/poems-syndrome-complicated-with-mu
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http://dx.doi.org/10.2147/OTT.S146221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166759PMC
September 2018
3 Reads

Spontaneous splenic rupture secondary to dabigatran: the last in a series of unfortunate events.

Clin Med (Lond) 2018 Oct;18(5):406-408

Royal Berkshire Hospital, Reading, UK.

We present the case of a 77-year-old woman who had an accidental fall in her garden, resulting in a fracture of her left ankle. After manipulation of the fracture, she developed sudden onset shortness of breath. An echo led to the diagnosis of Takotsubo cardiomyopathy. Read More

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http://www.clinmed.rcpjournal.org/lookup/doi/10.7861/clinmed
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http://dx.doi.org/10.7861/clinmedicine.18-5-406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334098PMC
October 2018
4 Reads

Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients.

J Emerg Med 2018 Nov 22;55(5):e113-e117. Epub 2018 Sep 22.

Department of Emergency Medicine, Alpert School of Medicine, Brown University, Providence, Rhode Island.

Background: Babesiosis is a zoonotic parasitic infection transmitted by the tick, Ixodes scapularis. Splenic infarct and rupture are infrequent complications of Babesia parasitemia, and have not been previously reported in the emergency medicine literature.

Case Report: We present two separate cases seen within 1 month at our institution: a case of splenic rupture and another case of splenic infarction due to Babesia parasitemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679183083
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http://dx.doi.org/10.1016/j.jemermed.2018.08.004DOI Listing
November 2018
16 Reads

Unexpected intraabdominal hemorrhage due to segmental arterial mediolysis following subarachnoid hemorrhage: A case of ruptured intracranial and intraabdominal aneurysms.

Surg Neurol Int 2018 29;9:175. Epub 2018 Aug 29.

Department of Emergency and Critical Care Medicine, Chikamori Hospital, Kochi, Japan.

Background: Segmental arterial mediolysis (SAM) is an uncommon vascular disease, which manifests as catastrophic intraabdominal hemorrhage caused by rupture of visceral dissecting aneurysms in most cases. The etiology of SAM is still unclear, but SAM may be a vasospastic disorder and the responsible pressor agent is norepinephrine. Recently, abdominal SAM coexisting with intracranial dissecting aneurysms has been reported, but the relationship between intraabdominal and intracranial aneurysms in SAM remains unclear, as no cases of concomitant abdominal SAM and ruptured intracranial saccular aneurysm have been reported. Read More

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http://dx.doi.org/10.4103/sni.sni_129_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130153PMC
August 2018
6 Reads

Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity.

Case Rep Nephrol 2018 19;2018:9607582. Epub 2018 Aug 19.

Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.

is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney injury with an active urinary sediment, initially suspicious for vasculitis, which was subsequently diagnosed as endocarditis. endocarditis may present with a crescentic glomerulonephritis (GN) and elevated PR3-ANCA antibody titers, mimicking ANCA-associated GN, with 54 cases reported in the literature. Read More

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http://dx.doi.org/10.1155/2018/9607582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120290PMC
August 2018
3 Reads

Stimulation of the Beta2 Adrenergic Receptor at Reperfusion Limits Myocardial Reperfusion Injury via an Interleukin-10-Dependent Anti-Inflammatory Pathway in the Spleen.

Circ J 2018 Oct 28;82(11):2829-2836. Epub 2018 Aug 28.

Department of Surgery, University of Virginia.

Background: In addition to the airway-relaxing effects, β adrenergic receptor (βAR) agonists are also found to have broad anti-inflammatory effects. The current study was conducted to define the role of βAR agonists in limiting myocardial ischemia/reperfusion injury (IRI). Methods and Results: Adult male wild-type (WT) and interleukin (IL)-10 knockout (KO) mice underwent a 40-min left coronary artery ligation and 60-min reperfusion. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-0061DOI Listing
October 2018
11 Reads
3.940 Impact Factor

Recurrent orbital bone sub-periosteal hematoma in sickle cell disease: a case study.

BMC Ophthalmol 2018 Aug 28;18(1):211. Epub 2018 Aug 28.

Department Of Ophthalmology, Faculty of Medicine, Taif University, Taif, Saudi Arabia.

Background: Sickle cell disease is a common inherited hemoglobinopathy and is associated with high morbidity and mortality. Vaso-occlusive crises commonly occur in individuals with SCD that results in high morbidity due to end-organ ischemia and infarction. These include splenic infarction, pulmonary involvement, acute chest syndrome, and orbital compression syndrome. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
Publisher Site
http://dx.doi.org/10.1186/s12886-018-0884-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114482PMC
August 2018
9 Reads

Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury.

J Leukoc Biol 2018 Dec 26;104(6):1173-1186. Epub 2018 Aug 26.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Alabama, USA.

Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients. However, the molecular and cellular mechanism of this provocative adverse effect is unclear. Our goal was to determine whether carprofen (CAP) impedes splenic leukocyte-directed acute inflammation-resolving response in cardiac injury. Read More

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http://dx.doi.org/10.1002/JLB.3A0618-223RDOI Listing
December 2018
9 Reads

Infarcted accessory spleen masquerading as a mesenteric cyst.

BMJ Case Rep 2018 Aug 16;2018. Epub 2018 Aug 16.

General Surgery, Seth GS Medical College and KEM Hospital, Mumbai, Maharshtra, India.

An accessory spleen is a rare entity which is usually asymptomatic. When symptomatic, it presents as an acute abdomen, with either torsion, rupture or haemorrhage. We present the case of a 20-year-old man who presented with chronic lower abdominal pain since 3 months and a lump in the left lower quadrant. Read More

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http://dx.doi.org/10.1136/bcr-2018-226130DOI Listing
August 2018
14 Reads

Detection of spleen, kidney and liver infarcts by abdominal computed tomography does not affect the outcome in patients with left-side infective endocarditis.

Medicine (Baltimore) 2018 Aug;97(33):e11952

Infectious Diseases Unit, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Cantabria, Spain.

Extra-cardiac abdominal complications are common in left-side infective endocarditis (LS-IE). The aim of this work was to study whether patients with LS-IE presenting splenic, renal, or liver (SRL) involvement seen in abdominal computed tomography (CT) had different clinical features, therapeutic plans, and outcome than those without these findings on CT.From January 2008 to April 2010, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in which abdominal CT was performed. Read More

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http://dx.doi.org/10.1097/MD.0000000000011952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112969PMC
August 2018
17 Reads
5.723 Impact Factor

Splenic blood-flow response following myocardial infarction in rat.

Can J Physiol Pharmacol 2018 Nov 13;96(11):1060-1068. Epub 2018 Aug 13.

a Department of Human Health and Nutritional Science, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

During physiological stress (e.g., exercise, hypoxia), blood flow is shunted to specific anatomical regions to protect critical organs; yet, splenic blood flow in these circumstances remains to be investigated. Read More

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0134
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http://dx.doi.org/10.1139/cjpp-2018-0134DOI Listing
November 2018
22 Reads

The Importance of Recognizing Wandering Spleen as a Cause of Recurrent Acute Pancreatitis.

Case Rep Gastrointest Med 2018 21;2018:7573835. Epub 2018 Jun 21.

Department of Gastroenterology and Hepatology, Brandon Regional Hospital, Brandon, Florida 33511, USA.

Wandering spleen, as its name suggests, is a rare condition where the spleen wanders in the abdomen and is most commonly found in the inferior quadrant as a palpable mass. It can have varying presentations and commonly presents as splenic torsion and very rarely as acute pancreatitis. It is imperative not to miss this diagnosis as it can lead to life-threatening complications in the form of splenic torsion/infarction. Read More

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http://dx.doi.org/10.1155/2018/7573835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032662PMC
June 2018
8 Reads