9,948 results match your criteria Spleen Trauma


The shock index, pediatric age-adjusted (SIPA) enhanced: Prehospital and emergency department SIPA values forecast transfusion needs for blunt solid organ injured children.

Surgery 2020 Jul 10. Epub 2020 Jul 10.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO; Department of Surgery, University of Colorado School of Medicine, Aurora, CO; Department of Surgery, Denver Health Medical Center, CO.

Background: The elevated shock index, pediatric age-adjusted (SIPA) has been found to accurately predict the need for blood transfusion in severely injured children. We sought to determine the utility of monitoring sequential SIPA values from the prehospital setting through the emergency department to identify children with a blunt liver or spleen injury who will require a blood transfusion.

Methods: We conducted a retrospective review of children 1 to 18 years old admitted to a level-1 pediatric trauma center with any grade blunt liver or spleen injury between 2009 and 2019. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.061DOI Listing

Giant mesenteric fibromatosis associated with non-Hodgkin lymphoma. a case report and literature review.

Acta Chir Belg 2020 Jul 9:1-13. Epub 2020 Jul 9.

Department of General Surgery, Hospital Universitario Son Espases, Palma de Mallorca, Spain.

Background: Mesenteric fibromatosis is a benign locally-aggressive mesenchymal neoplasm that lacks the potential for metastasis. It is related to Gardner's Syndrome, previous trauma, abdominal surgery, and prolonged intake of oestrogen. Differentially diagnosing this from similar tumours is crucial in order for establishing the appropriate treatment and only immunohistochemical features can be used for a definitive diagnosis. Read More

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The compelling arguments for the need of microvascular investigation in COVID-19 critical patients.

Authors:
Romeo Martini

Clin Hemorheol Microcirc 2020 Jun 19. Epub 2020 Jun 19.

Unità Operativa di Angiologia, Azienda Ospedaliera Universitaria di Padova, Padova, Italy.

The burden of pandemic COVID-19 is growing worldwide, as the continuous increases of contagion. Only 10-15% of the entire infected population has the necessity of intensive care unit (ICU) treatments. But, this relatively low rate of patients has absorbed almost the whole availability of ICU during few days, becoming at least in Italy, an emergency for the national health system. Read More

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http://dx.doi.org/10.3233/CH-200895DOI Listing

Laparoscopic Resection of a Left Upper Quadrant Mass Leading to a Surprise Diagnosis.

Case Rep Surg 2020 30;2020:8365061. Epub 2020 May 30.

University of Maryland Community Medical Group, Easton, MD, USA.

. Resplenectomy is most commonly done for the treatment of recurrent idiopathic thrombocytopenic purpura (ITP) refractory to medical management due to the regrowth of a missed accessory spleen. . Read More

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http://dx.doi.org/10.1155/2020/8365061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284930PMC

Non-Hodgkin's Lymphoma of the Anterior Maxilla Mimicking a Chronic Apical Abscess.

J Endod 2020 Jun 18. Epub 2020 Jun 18.

Pacific Oral Surgery & Dental Implant Studio, 26732 Crown Valley Pkwy #531, Mission Viejo, CA 92691 USA.

Non-Hodgkin lymphomas (NHL) are malignant neoplasms of the lymphatic system, typically occurring in the fifth through seventh decade of life. Tumors develop from abnormal lymphocyte proliferation and accumulation. While a majority of NHLs occur in nodal regions, 40% of cases appear in extranodal sites involving the stomach, spleen, Waldeyer's ring, central nervous system, lung, skin, and bone. Read More

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http://dx.doi.org/10.1016/j.joen.2020.06.010DOI Listing

Traumatic diaphragmatic rupture successfully managed in 4-year-old patient: Case report and literature review.

Int J Surg Case Rep 2020 Jun 11;72:237-240. Epub 2020 Jun 11.

Department of Surgery, Kendall Regional Medical Center, Miami, FL, USA; University of South Florida, Tampa, FL, USA.

Introduction: Traumatic diaphragmatic ruptures are rare injuries in the pediatric population that can present with dyspnea, abdominal pain, or even be asymptomatic.

Case Presentation: A 4-year-old boy presents to our Level 1 Pediatric Trauma Center after being hit by a car. He presented awake and alert but with low oxygen saturations and chief complaint of left sided abdominal and chest pain. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300228PMC

Niemann-Pick Disease Type B in Traumatic Splenic Rupture.

Am J Forensic Med Pathol 2020 Jun 12. Epub 2020 Jun 12.

From the Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

The rupture of spleen is common in clinical and forensic practice. Trauma is the most common cause of splenic rupture. Although rare, traumatic splenic rupture may occur in these individuals with asymptomatic underlying disease, and clinical and forensic pathologists may neglect the disease and diagnose only the traumatic splenic rupture. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000577DOI Listing

Abdominal splenosis and its differential diagnoses: What the radiologist needs to know.

Curr Probl Diagn Radiol 2020 May 19. Epub 2020 May 19.

Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata (BIND), University of Palermo, Palermo, Italy.

Splenosis is a benign acquired condition characterized by the presence of heterotopic viable splenic tissue in other organs or within cavities such as peritoneum, retroperitoneum, or thorax after splenic trauma or surgery. Abdominal splenosis is often an incidental finding and computed tomography and magnetic resonance usually allow a confident diagnosis. The typical enhancement that parallels the spleen is a useful hallmark of splenosis. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2020.04.012DOI Listing

Non-Traumatic Splenic Rupture After Open Surgery for Type A Aortic Dissection: A Case Report and Literature Review.

Heart Surg Forum 2020 May 14;23(3):E315-E317. Epub 2020 May 14.

Department of Intensive Care Unit of Cardiac Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Aortic dissection is a severe condition that involves a tear in the wall of the major artery carrying blood out of the heart (aorta). This cardiac disease has a high mortality, particularly Stanford type A, which involves the first part of the aorta. Aortic dissection is characterized by urgent onset, rapid progress, and poor outcome [Nienaber 2003; Mehta 2002]. Read More

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http://dx.doi.org/10.1532/hsf.2175DOI Listing

Total Pancreatectomy and Pancreatic Allotransplant in a Porcine Experimental Model.

Exp Clin Transplant 2020 Jun;18(3):353-358

From the Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.

Objectives: The main objective of this experimental study was to evaluate the feasibility of diabetes induction by total pancreatectomy and pancreatic allotransplant after diabetes induction by total pancreatectomy. The secondary objective was to evaluate metabolic (C-peptide, glycemia) and inflammatory (lactate and platelet levels) parameters after diabetes induction by total pancreatectomy and pancreatic allotransplant after total pancreatectomy.

Materials And Methods: The study protocol was approved by the French Minister of Research (APAFiS no. Read More

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http://dx.doi.org/10.6002/ect.2019.0291DOI Listing

Protective Effects of Biscoclaurine Alkaloids on Leukopenia Induced by Co- Radiation.

Evid Based Complement Alternat Med 2020 18;2020:2162915. Epub 2020 May 18.

Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, 100193 Beijing, China.

Objective: Leukopenia, a common complication of tumor chemoradiotherapy, contributes serious damage to the hematopoietic, gastrointestinal, and immune systems of the body and can cause delay, discontinuation, or even failure to tumor treatment, thereby greatly threatening human health. The present study aims to investigate the protective effects of biscoclaurine alkaloids (BA) on leukopenia.

Methods: This study was conducted on 60 Kunming mice, which were randomly divided into six groups containing 10 animals each. Read More

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http://dx.doi.org/10.1155/2020/2162915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251465PMC

Small bowel obstruction due to splenosis 30 years after splenectomy.

Ann R Coll Surg Engl 2020 Jun 8:e1-e3. Epub 2020 Jun 8.

Saint Charles Hospital, Mount Lebanon, Lebanon.

Splenosis is the autotransplantation of splenic tissue into abnormal locations due to trauma or iatrogenically. Usually, this causes no symptoms, but in rare cases the mass effect of the transplanted nodules can cause small bowel obstruction. Resection of the culprit splenic tissue is recommended, but not more extensive dissection of non-involved nodules. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0131DOI Listing
June 2020
1.223 Impact Factor

The protective role of spirulina and β-glucan in African catfish (Clarias gariepinus) against chronic toxicity of chlorpyrifos: hemato-biochemistry, histopathology, and oxidative stress traits.

Environ Sci Pollut Res Int 2020 Jun 4. Epub 2020 Jun 4.

Department of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh, Egypt.

Chlorpyrifos (CPF) is an insecticide that is commonly applied in the agriculture sector. However, little is known about the protective role of Spirulina platensis (SP) and/or β-glucan (BG) on African catfish exposed to chronic CPF toxicity. The fish (95 ± 5 g, initial weight) were assigned to 5 fiberglass tanks (500 L, 50 fish/tank) where the 1st and 2nd fed the basal diet, while the 3rd, 4th, and 5th fed diets with SP, BG, and SP+BG at 0. Read More

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http://dx.doi.org/10.1007/s11356-020-09333-8DOI Listing

Efficacy evaluation of different conservative treatments for blunt spleen rupture.

Minerva Med 2020 May 29. Epub 2020 May 29.

Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.

Background: This study aims to provide a reference for the clinical treatment of patients with spleen ruptures by analyzing and discussing the clinical effects of the conservative treatment.

Methods: The clinical data of 93 patients with blunt spleen rupture treated in the First Affiliated Hospital of University of Science and Technology of China from April 2015 to April 2018 were retrospectively analyzed. Among them, 84 cases were treated conservatively and 9 cases were treated surgically. Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06574-XDOI Listing

The effect of anticoagulation on outcomes after liver and spleen injuries: A research consortium of New England centers for trauma (ReCONECT) study.

Injury 2020 May 15. Epub 2020 May 15.

Yale School of Medicine, New Haven, CT, United States.

Background: Liver and spleen injuries are the most commonly injured solid organs, the effects of anticoagulation on these injuries has not yet been well characterized.

Study Design: Multicenter retrospective study.

Result: During the 4-year study period, 1254 patients, 64 (5%) on anticoagulation (AC), were admitted with liver and/or splenic injury. Read More

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http://dx.doi.org/10.1016/j.injury.2020.05.002DOI Listing

Atraumatic splenic rupture in a patient treated with apixaban: A case report.

Int J Surg Case Rep 2020 11;71:270-273. Epub 2020 May 11.

Sir Charles Gairdner Hospital, General Surgery - Western Australia Liver and Kidney (WALK), WA, Australia.

Introduction: Splenic rupture is often seen in the context of significant trauma. Atraumatic ruptures are described in the context of malignancy, inflammation or infection directly affecting the spleen. Splenic ruptures occurring in patients taking apixaban, a factor Xa inhibitor, are challenging due to the scarcity of a direct reversal agent. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264001PMC

Laparoscopic and Robotic Surgery for Splenic Artery Aneurysm: A Systematic Review.

Ann Vasc Surg 2020 May 29. Epub 2020 May 29.

Department of Surgery, Emergency Department - Division of Emergency and Trauma, Surgery, Sapienza University of Rome, Rome, Italy.

Background: Splenic artery aneurysms (SAAs) are the most frequent visceral aneurysms, with a life-threatening risk in case of rupture. Our systematic review investigated the features of minimally invasive surgical approaches in vascular surgery for SAAs: robotic surgery and laparoscopy.

Methods: PubMed, EMBASE, and the Web of Science were systematically searched for robotic or laparoscopic surgery reports in SAA up to January 2020. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.05.037DOI Listing

Major liver trauma post-mechanical cardiopulmonary resuscitation-the first reported case of survival with normal cardiovascular and neurological outcome.

Oxf Med Case Reports 2020 Apr 23;2020(4):omz144. Epub 2020 May 23.

Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Hill End Road, Harefield UB9 6JH, UK.

Cardiopulmonary resuscitation (CPR) is often conducted with mechanical devices, such as Lund University Cardiac Arrest System in the setting of cardiac arrest during coronary catheterization, to enable effective chest compressions for a prolonged period. Certain injuries from such devices are common such as skin lesions, sternal and rib fractures. Others are rarer, such as visceral injury to the heart, major vessels, lung, liver, spleen and stomach. Read More

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http://dx.doi.org/10.1093/omcr/omz144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243720PMC

Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1 Cell Depletion and Blockage of CD47/CD172a Signaling.

Front Immunol 2020 8;11:876. Epub 2020 May 8.

Division of Research, Department of Surgery, University of Cincinnati, Cincinnati, OH, United States.

Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about the kinetics of T cell dysfunction after burn and its underlying mechanisms. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232553PMC

Organ injury scaling 2018 update: spleen, liver and kidney.

Authors:
Ballari Sanjay

J Trauma Acute Care Surg 2020 May 27. Epub 2020 May 27.

Resident, Department of Radiodiagnosis.

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http://dx.doi.org/10.1097/TA.0000000000002821DOI Listing

A Delayed Splenic Tragedy Beyond the Scope of a Colonoscope: A Rare Find.

Cureus 2020 Apr 23;12(4):e7805. Epub 2020 Apr 23.

Internal Medicine, St. Mary Mercy Hospital, Livonia, USA.

Colonoscopy is considered a low-risk procedure worldwide. Complications include hemorrhage, bowel perforation, and splenic rupture on rare occasions. The incidence of splenic rupture estimates between 0. Read More

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http://dx.doi.org/10.7759/cureus.7805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249756PMC

One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility.

J Control Release 2020 May 25;324:471-481. Epub 2020 May 25.

Utah Center for Nanomedicine, Nano Institute of Utah, and University of Utah, Salt Lake City, Utah, United States; Department of Pharmaceutics and Pharmaceutical Chemistry, Nano Institute of Utah, and University of Utah, Salt Lake City, Utah, United States; Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States. Electronic address:

Chronic toxicity evaluations of nanotechnology-based drugs are essential to support initiation of clinical trials. Ideally such evaluations should address the dosing strategy in human applications and provide sufficient information for long-term usage. Herein, we investigated one-year toxicity of non-surface modified silica nanoparticles (SNPs) with variations in size and porosity (Stöber SNPs 46 ± 4. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.05.027DOI Listing

Basic fibroblast growth factor and agarose gel promote ​the ability of immune privilege of allogeneic cartilage transplantation in rats.

J Orthop Translat 2020 May 9;22:73-80. Epub 2019 Aug 9.

Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Linggong Road, Dalian, Liaoning, China.

Objective: Allogeneic cartilage transplantation is used to treat severe osteochondral defects or cartilaginous injury. However, acute immune rejection has been a key problem interfering with graft healing.

Methods: Full-thickness osteochondral defects were performed in Sprague Dawley rats. Read More

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http://dx.doi.org/10.1016/j.jot.2019.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231919PMC

Serial hemoglobin monitoring in adult patients with blunt solid organ injury: less is more.

Trauma Surg Acute Care Open 2020 14;5(1):e000446. Epub 2020 May 14.

Surgery, University of Florida College of Medicine, Jacksonville, Florida, USA.

Background: Patients who sustain blunt solid organ injury to the liver, spleen, or kidney and are treated nonoperatively frequently undergo serial monitoring of their hemoglobin (Hb). We hypothesized that among initially hemodynamically stable patients with blunt splenic, hepatic, or renal injuries treated without an operation, scheduled monitoring of serum Hb values may be unnecessary as hemodynamic instability, not merely Hb drop, would prompt intervention.

Methods: We performed a retrospective review of patients admitted to our urban Level 1 trauma center following blunt trauma with any grade III, IV, or V liver, spleen, or kidney injury from January 1, 2016 to December 31, 2016. Read More

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http://dx.doi.org/10.1136/tsaco-2020-000446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232739PMC

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model.

J Vis Exp 2020 Apr 24(158). Epub 2020 Apr 24.

Raymond Purves Bone and Joint Research Laboratory, Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney.

Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases, affecting patients suffering from pain and physical limitations. Recent evidence indicates a potential inflammatory component of the disease, with both T-cells and monocytes/macrophages potentially associated with the pathogenesis of OA. Further studies postulated an important role for subsets of both inflammatory cell lineages, such as Th1, Th2, Th17, and T-regulatory lymphocytes, and M1, M2, and synovium-tissue-resident macrophages. Read More

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http://dx.doi.org/10.3791/61008DOI Listing

Effect of Newcastle disease and infectious bronchitis live vaccines on the immune system and production parameters of experimentally infected broiler chickens with H9N2 avian influenza.

Comp Immunol Microbiol Infect Dis 2020 May 11;71:101492. Epub 2020 May 11.

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

H9N2 Avian influenza (AI) is an infectious disease which considered to have low pathogenic virulence, but in the case of coinfection with other pathogens it has the potential to become a major threat to the poultry industry. Infectious bronchitis (IB) and Newcastle diseases (ND) are other common problems to the poultry industry, which there are an extensive vaccination program against these viral pathogens. To investigate the effects of administration of infectious bronchitis and Newcastle disease live vaccines (IBLVs and NDLVs) in the presence of H9N2 AI infection on the immune system and some production parameters, 180 one-day-old broiler chicks were randomly allocated into six groups with different vaccination programs including H120 IBLV, 4/91 IBLV, B1 NDLV and LaSota NDLV. Read More

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http://dx.doi.org/10.1016/j.cimid.2020.101492DOI Listing

Heterotopic accessory spleen with squamous epithelial cyst in pancreas mimicking other pancreatic tumor: a case report.

Ann Transl Med 2020 Apr;8(7):507

Department of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China.

A 49-year-old female undergoing a periodic health examination at other hospital revealed a mass in the tail of pancreas. The patient denied any personal history of surgery except subtotal hysterectomy because of multiple myomas in uterus 7 years ago, family history of abdominal cancer and trauma. Physical examination and laboratory finding (including tumor marker) were unremarkable. Read More

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http://dx.doi.org/10.21037/atm.2020.03.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210170PMC

Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner.

Theranostics 2020 6;10(12):5225-5241. Epub 2020 Apr 6.

Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays an important pathogenic role. However, the current drugs for IBD treatment are far from optimal. Previous researches indicated that parthenolide (PTL) had not only anti-cancer properties but also strong anti-inflammatory activities. Read More

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http://dx.doi.org/10.7150/thno.43716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196297PMC
April 2020
7.827 Impact Factor

CT Findings of Pediatric Handlebar Injuries.

Radiographics 2020 May-Jun;40(3):815-826

From the Department of Radiology, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ 85016.

Direct bicycle handlebar injuries are a significant cause of chest and abdominal trauma and morbidity in the pediatric population. However, these injuries have been underemphasized. While blunt abdominal trauma has been described well, the literature is limited in reviewing trauma imaging specifically related to direct handlebar injuries in the pediatric population. Read More

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http://dx.doi.org/10.1148/rg.2020190126DOI Listing

Closing the Gap in Care of Blunt Solid Organ Injury in Children.

J Trauma Acute Care Surg 2020 Apr 16. Epub 2020 Apr 16.

Department of General Surgery, Yale University, New Haven, CT.

Introduction: Cross-sectional data of pediatric blunt solid organ injury (SOI) demonstrates higher rates of non-operative management and shorter lengths of stay (LOS) in pediatric (PTC) vs adult (ATC) or dual (DTC) trauma centers. Recent iterations of guidelines (McVay 2008, St Peter 2011, ATOMAC 2015) have emphasized physiologic parameters rather than injury grade in clinical decision making, improving resource allocation and decreasing LOS. We sought to evaluate how these guidelines have influenced care. Read More

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http://dx.doi.org/10.1097/TA.0000000000002757DOI Listing

Clinical Results of Distal Embolization in Grade V Splenic Injury: Four-Year Experience from a Single Regional Trauma Center.

J Vasc Interv Radiol 2020 Apr 24. Epub 2020 Apr 24.

Department of Trauma Surgery, Wonkwang University Hospital, Iksan-si, Republic of Korea.

Purpose: To evaluate the benefits and risks of splenic artery embolization (SAE) in patients with American Association for the Surgery of Trauma (AAST) grade V blunt spleen injury (BSI) MATERIALS AND METHODS: Medical records of 88 patients treated with SAE between April 2013 and May 2017 at a regional trauma care center were reviewed retrospectively. The BSI grade according to the AAST spleen injury scale (revised version 2018) was determined by using computed tomography (CT) images. A total of 42 patients (46. Read More

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http://dx.doi.org/10.1016/j.jvir.2020.01.029DOI Listing

Abdominal surgery prior to chronic psychosocial stress promotes spleen cell (re)activity and glucocorticoid resistance.

Sci Rep 2020 Apr 24;10(1):6917. Epub 2020 Apr 24.

Laboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, Ulm University, Ulm, Germany.

There is convincing evidence from different mouse models that chronic psychosocial stress promotes splenomegaly, basal and lipopolysaccharide (LPS)-induced in vitro splenocyte activation and insensitivity towards glucocorticoids (GC) in in vitro LPS-treated splenocytes. However, we just recently showed, employing the chronic subordinate colony housing (CSC) paradigm, that bite wounds received during stressor exposure drive these stress-induced spleen changes. As skin wounds induced by planned surgery or physical trauma are more adequately reflecting what chronically stressed humans are likely to experience, it was the objective of the present study to investigate whether abdominal surgery prior to stressor exposure also promotes respective stress-induced spleen effects in the absence of any bite wounds. Read More

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http://dx.doi.org/10.1038/s41598-020-63419-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181742PMC

Spontaneous splenic rupture associated with bacteremia and dual antiplatelet therapy.

Proc (Bayl Univ Med Cent) 2020 Apr 10;33(2):241-242. Epub 2020 Jan 10.

Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at HoustonHoustonTexas.

Splenic rupture is a life-threatening condition that usually occurs after blunt abdominal trauma. It can lead to hemorrhagic shock and death if not diagnosed quickly. Rarely, spontaneous rupture of the spleen may occur without a history of trauma. Read More

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http://dx.doi.org/10.1080/08998280.2019.1709609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155991PMC

Predictors of False-Negative Focused Assessment With Sonography for Trauma Examination in Pediatric Blunt Abdominal Trauma.

Pediatr Emerg Care 2020 May;36(5):e274-e279

Department of Emergency Medicine, Denver Health Medical Center, Denver.

Objectives: This study investigated associations between patient and injury characteristics and false-negative (FN) focused assessment with sonography for trauma (FAST) in pediatric blunt abdominal trauma (BAT). We also evaluated the effects of FN FAST on in-hospital mortality and length of stay (LOS) variables.

Methods: This retrospective cohort studied children younger than 18 years between January 1, 2002, and December 31, 2013, with BAT, documented FAST, and pathologic fluid on computed tomography, surgery, or autopsy. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002094DOI Listing

Prevention of Decompression Sickness by Novel Artificial Oxygen Carriers.

Med Sci Sports Exerc 2020 Apr 1. Epub 2020 Apr 1.

University Duisburg-Essen, University Hospital Essen, Institute of Physiology, CENIDE, Essen, Germany.

For three decades, studies have demonstrated the therapeutic efficacy of perfluorocarbons (PFCs) in reducing the onset of decompression trauma. However, none of these emulsion-based preparations are accepted for therapeutic use in the western world, mainly because of severe side-effects and a long organ retention time. A new development to guarantee a stable dispersion without these disadvantages is the encapsulation of PFCs in nanocapsules with an albumin shell. Read More

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http://dx.doi.org/10.1249/MSS.0000000000002354DOI Listing

The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model.

Future Microbiol 2020 Apr 6;15:401-412. Epub 2020 Apr 6.

Department of Histology & Embryology, Faculty of Medicine, Kafkas University, Kars, Turkey.

The objective of this study was to evaluate the possible protective effects of probiotic bacteria, especially and strains, on 4,4'-dichlorodiphenyltrichloroethane (DDT)-induced toxicity. For this reason, we evaluated the relationship between probiotics and toxicity by checking immunological and immunohistochemical parameters. Probiotic pretreatment was applied to 36 Wistar albino rats for 12 consecutive days. Read More

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http://dx.doi.org/10.2217/fmb-2020-0005DOI Listing

Complications in the adult asplenic patient: A review for the emergency clinician.

Am J Emerg Med 2020 Mar 26. Epub 2020 Mar 26.

Department of Emergency Medicine, Rush University Medical Center, United States.

Background: The spleen performs several important physiologic functions. However, patients can have functional asplenia or have their spleen removed for a number of reasons, which can put them at risk for several dangerous complications.

Objective: This narrative review provides a focused evaluation of adult asplenic patients and complications in the emergency departing setting. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.03.049DOI Listing

Intrahepatic splenosis demonstrated by diffusion weighted MRI with histologic confirmation.

Radiol Case Rep 2020 May 19;15(5):602-606. Epub 2020 Mar 19.

Department of Hospital Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

Acquired ectopic splenic tissue is called splenosis, which is common after the history of trauma or surgical exploration. We present a rare case of intrahepatic splenosis in 36-year-old male patient mimicking a liver neoplasm on imaging however presented with left flank pain for 5 months and had remote history of splenectomy after splenic rupture from trauma. We discuss various imaging modalities and the role of various magnetic resonance imaging sequences and nuclear medicine examination. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090284PMC

Thoracic vertebrae fracture: Is it an indicator of abdominal injury?

Am J Emerg Med 2020 Mar 9. Epub 2020 Mar 9.

Surgical Division, Hillel Yaffe Medical Center, Hadera, Israel, affiliated with Rappoport Medical School, Technion, Haifa, Israel.

Purpose: Traumatic vertebral fracture accounts for 10-15% of trauma related admissions. While the correlation between lumbar vertebral fractures and abdominal injuries is well established, the relationship between thoracic vertebral fractures (TVF) and abdominal injuries is comparatively less well elucidated. Using a large national trauma database, we aimed to examine the incidence and severity of associated abdominal injuries in blunt trauma patients suffering from TVF. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.03.016DOI Listing

Post-splenectomy Sepsis: A Review of the Literature.

Cureus 2020 Feb 6;12(2):e6898. Epub 2020 Feb 6.

Pediatrics, Dow University of Health Sciences, Karachi, PAK.

The spleen is an intraperitoneal organ that performs vital hematological and immunological functions. It maintains both innate and adaptive immunity and protects the body from microbial infections. The removal of the spleen as a treatment method was initiated from the early 1500s for traumatic injuries, even before the physiology of spleen was properly understood. Read More

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http://dx.doi.org/10.7759/cureus.6898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059871PMC
February 2020

Diagnosis of drowning using postmortem computed tomography combined with endoscopic autopsy: A case report.

Medicine (Baltimore) 2020 Mar;99(11):e19182

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai.

Rationale: Postmortem forensic imaging technologies provide a noninvasive/minimally invasive approach for imaging of internal organ structures of the human body to detect injuries, diseases, and other morphologic changes. Currently, postmortem forensic imaging methods have been widely used in determination of the cause of death. However, these methods do not allow histologic examinations. Read More

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http://dx.doi.org/10.1097/MD.0000000000019182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220088PMC

Improved mouse sciatic nerve regeneration following lymphocyte cell therapy.

Mol Immunol 2020 05 13;121:81-91. Epub 2020 Mar 13.

Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, 13083-862, Campinas, SP, Brazil. Electronic address:

Traumatic injury to the peripheral nervous system (PNS) is the most common cause of acquired nerve damage and impairs the quality of life of patients. The success of nerve regeneration depends on distal stump degeneration, tissue clearance and remodeling, processes in which the immune system participates. We previously reported improved motor recovery in sciatic nerve crush mice following adoptive transfer of lymphocytes, which migrated to the lesion site. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.03.003DOI Listing

Changes in Approach to Solid Organ Injury: What the Radiologist Needs to Know.

Can Assoc Radiol J 2020 Aug 13;71(3):352-361. Epub 2020 Mar 13.

Department of Emergency Radiology, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada.

This review aims to examine the challenges facing radiologists interpreting trauma computed tomography (CT) images in this era of a changing approach to management of solid organ trauma. After reviewing the pearls and pitfalls of CT imaging protocols for detection of traumatic solid organ injuries, we describe the key changes in the 2018 American Association for the Surgery of Trauma Organ Injury Scales for liver, spleen, and kidney and their implications for management strategies. We then focus on the important imaging findings in observed in patients who undergo nonoperative management and patients who are imaged post damage control surgery. Read More

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http://dx.doi.org/10.1177/0846537120908069DOI Listing

Antimicrobial silver-coating for locking plates shows uneventful osteotomy healing and good biocompatibility results of an experimental study in rabbits.

Injury 2020 Apr 24;51(4):830-839. Epub 2020 Feb 24.

Department of Trauma Surgery, University Medical Centre, Regensburg, Germany. Electronic address:

Infections after internal fixation of fractures remain a challenge. Silver is known for its antimicrobial activity, including activity against multi-resistant strains. The aim of the current study was to analyze the biocompatibility and potential influence on the osteotomy healing process of a silver-coating technology for locking plates compared to silver-free locking plates in an established rabbit model. Read More

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http://dx.doi.org/10.1016/j.injury.2020.02.115DOI Listing
April 2020
2.137 Impact Factor

Increased long-term pneumonia risk for the trauma-related splenectomized population - a population-based, propensity score matching study.

Surgery 2020 05 3;167(5):829-835. Epub 2020 Mar 3.

Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Splenectomy is the life-saving treatment for high-grade spleen trauma. Splenectomized patients are at a significant infection risk. However, the trauma-induced splenectomy results in less incidence of postsplenectomy infection than the hematologic disorder. Read More

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http://dx.doi.org/10.1016/j.surg.2020.01.006DOI Listing

Update: Splenic Artery Embolization in Blunt Abdominal Trauma.

Semin Intervent Radiol 2020 Mar 4;37(1):97-102. Epub 2020 Mar 4.

Department of Radiology, Emory University School of Medicine, Atlanta, Georgia.

The spleen is the most commonly injured organ after blunt abdominal trauma. Nonoperative management with splenic arterial embolization (SAE) is the current standard of care for hemodynamically stable patients. Current data favor the use of proximal and coil embolization techniques in adults, while observation is suggested in the pediatric population. Read More

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http://dx.doi.org/10.1055/s-0039-3401845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056344PMC

Contemporary Management of Hepatic Trauma: What IRs Need to Know.

Semin Intervent Radiol 2020 Mar 4;37(1):35-43. Epub 2020 Mar 4.

Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia.

Trauma remains one of the leading causes of death in the United States in patients younger than 45 years. Blunt trauma is most commonly a result of high-speed motor vehicular collisions or high-level fall. The liver and spleen are the most commonly injured organs, with the liver being the most commonly injured organ in adults and the spleen being the most affected in pediatric blunt trauma. Read More

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http://dx.doi.org/10.1055/s-0039-3401838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056342PMC

Single segment of spleen autotransplantation, after splenectomy for trauma, can restore splenic functions.

World J Emerg Surg 2020 Mar 4;15(1):17. Epub 2020 Mar 4.

Department of Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Cannizzaro Hospital, Via Messina 829, 95126, Catania, Italy.

Background: Splenectomy is sometimes necessary after abdominal trauma, but splenectomized patients are at risk of sepsis due to impaired immunological functions. To overcome this risk, autotransplantation of the spleen by using a new technique has been proposed, but so far, a demonstration of functionality of the transplanted tissue is lacking.

Methods: We therefore evaluated 5 patients who underwent a splenic autotransplant in comparison with 5 splenectomized patients without splenic autotransplant and 7 normal subjects. Read More

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http://dx.doi.org/10.1186/s13017-020-00299-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057566PMC
March 2020
1.062 Impact Factor

A rare case of pancreatic splenosis and a literature review.

Ann Ital Chir 2020 Jan 31;9. Epub 2020 Jan 31.

Splenosis is a clinical condition characterized by the presence of ectopic splenic tissue in the abdominal cavity occurring after abdominal trauma or surgical procedure involving the spleen. We present a case of an 80-year-old Caucasian male who underwent splenectomy at the age of 36, with a prior diagnosis of cancer of the left kidney associated with a pancreatic neoformation. This study compare our case with similar published and reviev the Literature. Read More

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January 2020

Splenic injuries secondary to colonoscopy: Rare but serious complication.

World J Gastrointest Surg 2020 Feb;12(2):55-67

Department of Gastroenterology, Advent Health Hospital, Orlando, FL 32804, United States.

Background: Colonoscopy is a safe and routine diagnostic and therapeutic procedure for evaluation of large bowel diseases. Most common procedure related complications include bleeding and perforation but rarely a splenic Injury.

Aim: To investigate the reason for colonoscopy, presentation of patient with spleen injury, types of injury, diagnosis, management and outcomes of patients. Read More

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http://dx.doi.org/10.4240/wjgs.v12.i2.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044106PMC
February 2020