Search Our Scientific Publications & Authors

Scand J Trauma Resusc Emerg Med 2019 Feb 14;27(1):19. Epub 2019 Feb 14.

, Yerevan, Armenia.

In bacteremia the majority of bacterial species are killed by oxidation on the surface of erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing bacteria overcome this mechanism of human innate immunity by versatile respiration, production of antioxidant enzymes, hemolysins, exo- and endotoxins, exopolymers and other factors that suppress host defense and provide bacterial survival. Entering the bloodstream in different forms (planktonic, encapsulated, L-form, biofilm fragments), they cause different types of sepsis (fulminant, acute, subacute, chronic, etc. Read More

IBRO Rep 2019 Jun 11;6:74-86. Epub 2019 Jan 11.

A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

Inflammation is a prominent feature of the neuropathology of amyotrophic lateral sclerosis (ALS). Emerging evidence suggests that inflammatory cascades contributing to the disease progression are not restricted to the central nervous system (CNS) but also occur peripherally. Indeed, alterations in T cell responses and their secreted cytokines have been detected in ALS patients and in animal models of ALS. Read More

Cureus 2018 Nov 17;10(11):e3604. Epub 2018 Nov 17.

General Surgery, Jinnah Postgraduate Medical College, Karachi, PAK.

Introduction Abdominal injuries are responsible for 10% of the mortalities due to trauma. Delays in early diagnosis or misdiagnoses are two major reasons for the mortality and morbidity associated with abdominal trauma. The objectives of this study were to determine the frequency of visceral injuries in patients with abdominal trauma and compare the frequency of visceral injuries in patients with blunt and penetrating abdominal trauma. Read More

J Interferon Cytokine Res 2019 Feb 24;39(2):95-105. Epub 2019 Jan 24.

1 National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi Province, China .

Our study aimed to investigate the histologic and immunological changes of portal hypertension (PH) pre- and postsplenectomy in hepatitis B virus (HBV)-related cirrhosis. Peripheral blood samples were obtained from 30 patients with HBV-related cirrhosis and PH at pre- and postsplenectomy time points and from 15 healthy subjects. Spleen tissue specimens were collected from 15 of the patients with HBV-related cirrhosis and from 8 control patients who had undergone splenectomy due to trauma. Read More

Eur J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Division of Neonatology, Careggi University Hospital of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 2500 to 5000 infants. The use of lung ultrasound (LUS) for its diagnosis has been reported in only two case reports. The aim of this study was to report the LUS pattern of CDH in a case series of infants with respiratory distress. Read More

J Pediatr Surg 2018 Dec 5. Epub 2018 Dec 5.

Service de Chirurgie Générale Digestive, Cancerologique, Bariatrique et Métabolique, Hôpital Avicenne, Bobigny, France; Laboratoire d'Ethique Médicale et de Médecine Légale, Université Paris "Descartes", Paris, France.

Background/purpose: In order to avoid consequences of total splenectomy (including severe postsplenectomy sepsis), partial splenectomy (PS) is increasingly reported. Without guidelines and indications concerning a rarely-indicated procedure, a review of literature should be an asset.

Methods: A systematic review of all PSs from 1960 to December 2017 was performed, with special focus on surgical indications, sites of resection, approaches and techniques of vascular dissection and parenchymal section/hemostasis of the spleen, perioperative morbidity/mortality, including complications compelling to perform total splenectomy. Read More

Acta Biomed 2019 Jan 15;89(4):505-512. Epub 2019 Jan 15.

.

Aim: In our study we investigated characteristics and degree of intra-abdominal solid organ injuries according to tomographic imaging in pediatric patients who presented to our emergency clinic with possible abdominal injuries and to whom US and/or abdominal tomography were applied.

Materials And Methods: 1066 pediatric patients were included in the study. The age, gender, injury localization, injury type, injury mechanism, abdominal US and CT results, and treatment specifics of patients were evaulated. Read More

Emergencias 2019 Ene;31(1):15-20

Servicio de Cirugía General y Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Objectives: To describe the abdominal injuries treated in our hospital. We assessed the behavior and reliability of prognostic scales, analyzing the correlations between them and therapeutic decisions and outcomes.

Material And Methods: Retrospective study including all patients with major abdominal injuries admitted to our hospital between 2009 and 2015. Read More

Rozhl Chir 2018 ;97(12):546-550

Introduction: Despite current efforts at the most conservative approach possible to splenic injury, splenectomy remains a relatively common surgical procedure. Indications for splenectomy, however, are not limited to spleen injury. In senior patients in particular, non-traumatic reasons for splenectomy becomemore frequent. Read More

Stem Cell Res Ther 2019 Jan 11;10(1):22. Epub 2019 Jan 11.

Institute of Liver Diseases, Affiliated Hospital of Jining Medical University, Jining, 272067, People's Republic of China.

Background: Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important. Human liver stem cells (HLSCs) are early undifferentiated cells that have been implicated in the regeneration and functional reconstruction of the liver. Read More

Scand J Trauma Resusc Emerg Med 2019 Jan 11;27(1). Epub 2019 Jan 11.

Division of Trauma and Emergency Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan City, Taiwan.

Background: The long-term treatment trends of splenic injuries can provide guidance when treating trauma patients. The nonoperative management (NOM) of splenic injuries was introduced in early 1989. After decades of development, it has proven to be safe and is now the primary treatment choice worldwide. Read More

Ann R Coll Surg Engl 2019 Jan 3:1-4. Epub 2019 Jan 3.

Northumbria Healthcare NHS Foundation Trust , UK.

Introduction: The aim of this study was to review the experience of general surgeons performing splenectomy in a district general hospital. The outcomes are discussed together with potential reasons for the increasing rarity of the procedure.

Methods: A retrospective cohort study was carried out of all patients undergoing splenectomy (as identified by a single trust pathology department on receipt of splenic samples) between 1 January 2000 and 1 May 2017. Read More

Ann Surg 2018 Dec 20. Epub 2018 Dec 20.

Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: The primary objective of this study was to evaluate the utility, clinical impact, and work flow of a new trauma hybrid operating theater.

Summary Background Data: The potential utility and clinical benefit of hybrid operating theaters are increasingly postulated. Unfortunately, the clinical outcomes and efficiencies of these environments remain unclear. Read More

Int J Surg Case Rep 2019 22;54:113-115. Epub 2018 Nov 22.

Division of Trauma, Bronx, NY, USA; School of Medicine, City University of New York, New York, NY, USA; College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA. Electronic address:

Introduction: Large bowel obstruction (LBO) warrants prompt evaluation and management. Although causes of LBO are most commonly intrinsic to the colon (e.g. Read More

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Nov;34(11):961-968

Institute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China. *Corresponding author, E-mail:

Objective To study the effect of CD11b agonist leukadherin-1 (LA1) on the aggregation and immunosuppressive function of myeloid-derived suppressor cells (MDSCs) and its therapeutic effect on the condition of endotoxic shock mice. Methods The percentages of MDSCs , granulocytic myeloid-derived suppressor cells(G-MDSCs)and monocytic myeloid-derived suppressor cells(M-MDSCs)in spleen were detected by flow cytometry, after C57BL/6 female mice were injected of LA1 to activate through abdominal cavity for 12 hours and 48 hours. MDSCs were induced from the femur and tibia of C57BL/6 female mice in vitro. Read More

J Trauma Acute Care Surg 2019 Jan;86(1):86-91

From the Department of Surgery, The Children's Hospital at OU Medical Center (P.M.G., P.M, Z.S., R.W.L.), Oklahoma City, Oklahoma; Pediatric Trauma Center, Dell Children's Medical Center (N.M.G., K.A.L., D.W.T.), Austin, Texas; Department of Pediatric Surgery, Children's Healthcare of Atlanta (A.B.), Atlanta, Georgia; Level I Pediatric Trauma Center, Phoenix Children's Hospital (M.E.L., C.S.L., D.M.N., D.J.O.), Phoenix, Arizona; Department of Pediatric Surgery, Arkansas Children's Hospital (R.T.M.), Little Rock, Arkansas; Department of Pediatric Surgery, Le Bonheur Children's Hospital (J.W.E.), Memphis, Tennessee; Pediatric Surgery Department, Children's Medical Center (A.C.A.), Dallas, Texas; Department of Pediatric Surgery, Akron Children's Hospital (T.A.P.), Akron, Ohio; Pediatric Surgery, American Family Children's Hospital (C.W.L.), Madison, Wisconsin; Pediatric Surgery, Mercy Children's Hospital (S.D.S.P.), Kansas City, Missouri.

Background: Focused Abdominal Sonography for Trauma (FAST) examination has long been proven useful in the management of adult trauma patients, however, its utility in pediatric trauma patients is not as proven. Our goal was to evaluate the utility of a FAST examination in predicting the success or failure of nonoperative management (NOM) of blunt liver and/or spleen (BLSI) in the pediatric trauma population.

Methods: A retrospective analysis of a prospective observational study of patients younger than 18 years presenting with BLSI to one of ten Level I pediatric trauma centers between April 2013 and January 2016. Read More

BMC Surg 2018 Dec 20;18(1):119. Epub 2018 Dec 20.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road, Nanning, 530007, Guangxi, China.

Background: Spleen leaves its normal anatomical position and appears in other locations, which is called ectopic spleen. It is most commonly found in the abdomen or pelvis with seeding of the peritoneum, omentum or mesentery. A few of cases of thoracic splenosis associated with traumatic diaphragmatic rupture have been reported. Read More

World J Clin Cases 2018 Dec;6(15):1047-1052

Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.

This report describes a 52-year-old male patient with blunt abdominal traumatic rupture of the spleen due to injuries sustained in an automobile accident. Following splenectomy, the patient developed a gastric fistula. He underwent a long period of conservative treatment, including antibiotics and total parenteral nutrition, which was ineffective. Read More

Eur Surg 2018 20;50(6):285-298. Epub 2018 Jul 20.

1Department of Visceral, Transplantation and Thoracic Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.

Background: Non-operative management (NOM) of blunt hepatic and splenic injuries has become popular in haemodynamically stable adult patients, despite uncertainty about efficacy, patient selection, and details of management. Up-to-date strategies and practical recommendations are presented.

Methods: A selective literature search was conducted in PubMed and the Cochrane Library (1989-2016). Read More

Wideochir Inne Tech Maloinwazyjne 2018 Dec 30;13(4):460-468. Epub 2018 May 30.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: Throughout our 20 years of experience, we have used several different techniques for laparoscopic splenectomy (LS). However, two methods have been used most frequently: "vessels first" and "hilar transection".

Aim: To evaluate the outcomes of LS performed with these two different approaches. Read More

Mol Med Rep 2019 Feb 4;19(2):841-850. Epub 2018 Dec 4.

Spleen, Stomach and Hepatobiliary Department, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, Henan 450004, P.R. China.

α‑lipoic acid (ALA) is a naturally occurring antioxidant with protective effects against various hepatic injuries. The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis. The widely used liver cirrhosis rat model was established via an intraperitoneal injection of 2 mg/kg 50% CCl4, three times/week for 8 weeks. Read More

Radiat Res 2019 Feb 6;191(2):162-175. Epub 2018 Dec 6.

a Columbia University Medical Center, New York, New York.

Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that may be induced by high-energy galactic cosmic rays encountered on interplanetary space missions. To collect data on the effects of space radiation on the human hematopoietic system in vivo, we used a humanized mouse model. Read More

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):569-574

Department of Pediatric Surgery, Marmara University Faculty of Medicine, İstanbul-Turkey.

Background: Although a nonoperative treatment approach is preferred for blunt liver and spleen trauma in childhood, there are significant differences between clinics in the algorithms used. The approach to high-grade liver and spleen injury is still controversial, particularly as grade V liver and spleen injuries are not included in the American Pediatric Surgical Association guideline. The aim of this study was to present experience with a non-operative treatment approach to children with high-grade liver and spleen injuries. Read More

Int J Burns Trauma 2018 20;8(5):117-125. Epub 2018 Oct 20.

Nuclear Medicine Department, Isfahan University of Medical Sciences Isfahan, IR Iran.

Background: The most prevalent method of treating splenic injury is by splenectomy. This method is followed by postoperative complications. Therefore, less invasive procedures such as splenic angioembolization are introduced. Read More

BJS Open 2018 Dec 10;2(6):426-432. Epub 2018 Jul 10.

Department of General Surgery, Chang Gung Memorial Hospital Chang Gung University Tao-Yuan City Taiwan.

Background: The aim of this study was to analyse outcomes of spleen-preserving (SPDP) and spleen-sacrificing (SSDP) distal pancreatectomy in adults with severe blunt pancreatic injuries.

Methods: This was an observational study of adult patients who underwent distal pancreatectomy for grade III or IV blunt pancreatic injury between 1991 and 2015. Outcomes of SPDP and SSDP were compared. Read More

Malar J 2018 Dec 4;17(1):448. Epub 2018 Dec 4.

Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease, including fatal outcomes. Spontaneous splenic rupture is a rare, but severe complication of malaria and has not been reported previously for knowlesi malaria. Read More

Radiol Med 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiological Sciences, Azienda Ospedaliero Universitaria Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

Introduction: We describe the use of contrast-enhanced ultrasound (CEUS) in the diagnosis of delayed splenic vascular injury (DSVI) and active extravasation (DAE) during spleen injury follow-up. CEUS might be used instead of contrast-enhanced computed tomography (CECT) during spleen injury follow-up in order to reduce radiation exposure.

Objective: Assess diagnostic comparability between CEUS and CECT in the evaluation of DSVI and DAE during spleen injury follow-up. Read More

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):815-820

Trauma Research Center, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China.

To explore influence of vagus nerve on multiple organ function and immune reaction of T lymphocytes in septic rats. Forty Sprague-Dawley rats were divided into sham injury group, sepsis group, vagus nerve stimulation (VNS) group, and vagotomy (VGX) group, according to the random number table, with 10 rats in each group. Rats in sepsis group, VNS group, and VGX group were inflicted with sepsis by cecal ligation and puncture (CLP). Read More

J Pediatr Surg 2018 Oct 31. Epub 2018 Oct 31.

Division of Pediatric Surgery, Department of Surgery, University of Utah School of Medicine, 100 North Mario Capecchi Drive, Suite 3800, Salt Lake City, UT 84113. Electronic address:

Background/purpose: Nonoperative management of blunt solid organ injuries continues to progress and improve cost-effective utilization of resources while maximizing patient safety. The purpose of this study is to compare resource utilization and patient outcomes after changing admission criteria from a grade-based protocol to one based on hemodynamic stability.

Methods: A retrospective review of isolated liver and spleen injuries was done using prospectively collected trauma registry data from 2013 to 2017. Read More

J Surg Res 2018 Dec 14;232:293-297. Epub 2018 Jul 14.

Trauma/Critical Care Division, University of Kansas Medical Center, Kansas City, Kansas. Electronic address:

Background: The spleen is the second most commonly injured solid organ during blunt abdominal trauma. Although total splenectomy is frequently performed for injury, splenic rupture can also be managed by splenic embolization. For these patients, current Advisory Committee on Immunization Practices (ACIP) recommendations indicate that if 50% or more of the splenic mass is lost, patients should be treated as though they are asplenic. Read More

J Trauma Acute Care Surg 2018 Dec;85(6):1119-1122

From the Shock Trauma (R.A.K.), University of Maryland School of Medicine, Baltimore, Maryland, University of Florida College of Medicine Jacksonville (M.C.), Jacksonville, Florida; Shock Trauma and Department of Radiology and Nuclear Medicine (K.S.), University of Maryland School of Medicine, Baltimore, Maryland; Department of Surgery (B.Z.), Indiana University School of Medicine, Indianapolis, Indiana; Scott Department of Urology (M.C.), Baylor College of Medicine, Houston, Texas; Department of Surgery (C.C.), University of Colorado, Denver, Colorado; Department of Surgery (K.K.), UCSF Fresno, California; Department of Surgery (K.S.), Yale School of Medicine; New Haven, Connecticut; and Department of Surgery (G.T.T.), Scripps Memorial Hospital La Jolla; La Jolla, California.

Tech Coloproctol 2018 10 20;22(10):767-771. Epub 2018 Nov 20.

Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Background: Splenic injury can occur during colorectal surgery especially in cases, where the splenic flexure is mobilized. The aim of this study was to analyze whether the operative approach (laparoscopic vs. open) was associated with an increased risk for splenic injury during colorectal surgery and to compare the outcomes of different management options. Read More

Vet Immunol Immunopathol 2018 Nov 15;205:1-9. Epub 2018 Oct 15.

Department of Biology, University of Waterloo, 200 University Ave W., Waterloo, ON, N2L 3G1 Canada. Electronic address:

Telemetry transmitters are frequently used in studies of wild fish migration and behavior. Although the effects of surgically implanted transmitters on survival, tag retention, healing and growth have been studied, there has been little research regarding the potential immune response induced by these transmitters. In the current study, mature rainbow trout received either surgical implantation of an acoustic transmitter or a sham surgical procedure. Read More

World J Emerg Surg 2018 31;13:50. Epub 2018 Oct 31.

6Trauma Surgery, Denver Health, Denver, CO USA.

Abdominopelvic trauma has been for decades classified with the AAST-OIS (American Association for the Surgery of Trauma-Organ Injury Scale) classification. It has represented a milestone. At present, the medical evolutions in trauma management allowed an incredible progress in trauma decision-making and treatment. Read More

J Ultrasound 2018 Nov 16. Epub 2018 Nov 16.

Paediatric Radiology Department, "Federico II" University Hospital, Naples, Italy.

In infants and children, the spleen is involved in many pathological processes, whether those processes are isolated or related to systemic diseases. Pathology of the pediatric spleen includes congenital anomalies, splenomegaly, trauma, focal lesions, infarction, and tumors. Ultrasonography (US) is a widely available, fast, noninvasive imaging technique to assess the size, shape, and position of the spleen, as well as to define splenic echotexture. Read More

Scand J Trauma Resusc Emerg Med 2018 Nov 16;26(1):97. Epub 2018 Nov 16.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: This study was performed to gain insights into novel therapeutic approaches for acute systemic inflammation in heatstroke. Bone marrow-derived mononuclear cells (BMMNCs) secrete anti-inflammatory proteins and have protective effects against acute inflammation. Recent evidence suggested that transplantation of BMMNCs can reduce the acute tissue injury caused by regional myocardial reperfusion and the lung dysfunction induced by lipopolysaccharides. Read More

Int J Biol Sci 2018 20;14(13):1834-1844. Epub 2018 Oct 20.

Department of Obstetrics and Gynaecology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China.

Copper nanoparticles (Cu-NPs) and other inorganic nanomaterials have caused increasing concern owing to be widely used. Early studies have reported that they can result in injuries to the kidney, liver and spleen of mice; cause embryonic damage; and inhibit the reproductive capacity of red worms. However, few studies have reported the toxicity of Cu-NPs on the reproductive systems of mammals. Read More

J Minim Access Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of General and Minimal Access Surgery and Robotic Surgery, Indraprastha Apollo Hospitals, New Delhi, India.

Splenic cysts are not so common in incidence. Only 800-850 cases have been reported till now in the literature. Splenic cysts can be further classified into parasitic and non-parasitic cysts. Read More

Am J Surg 2018 Dec 5;216(6):1192-1204. Epub 2018 Feb 5.

Department of Surgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Objectives: No standard classification exists for post-splenectomy thrombosis of splenic, mesenteric, and portal vein (PST-SMPv). The goal of this study was to review our institution's experience with PST-SMPv and to perform a systematic literature review.

Methods: A retrospective review of all patients undergoing splenectomy from 1995-2016 at our institution was performed. Read More

Scott Med J 2018 Oct 31:36933018801449. Epub 2018 Oct 31.

1 Physician, Liver Unit, Rambam Health Care Campus, Israel.

Introduction: Numerous conditions may cause liver lesions, solitary or multiple, benign or malignant. It can be crucial to establish the correct diagnosis. Splenosis is a rare condition that may result from the spillage of cells from the splenic pulp following abdominal trauma, accidental lesions to the spleen during operation or elective splenectomy. Read More

Curr Urol 2018 Oct 30;12(1):33-38. Epub 2018 Jun 30.

Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt.

Introduction: Surgical fires are unique topics that belong to surgical never events and deserve urological attention.

Materials And Methods: A retrospective search of our hospital records was done for the states of electrosurgical never events in the period from July 2001 to June 2016. The included events were classified according to the site of occurrence in relation to the patient's body and possibilities of human involvement. Read More

J Gastrointest Surg 2018 Oct 26. Epub 2018 Oct 26.

Department of Hepato-biliary and Pancreas Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Background: Herein, we assess the safety and feasibility of dual-incision laparoscopic spleen-preserving distal pancreatectomy (DILSPDP) through lateral approach with reduced trocars for benign and low-grade malignancy in pancreas tail. We compare DILSPDP with surgical outcomes of conventional laparoscopic spleen-preserving distal pancreatectomy (LSPDP).

Methods: Patients with benign pancreas tail mass that had been scheduled for LSPDP were selected to undergo DILSPDP. Read More

Front Aging Neurosci 2018 11;10:292. Epub 2018 Oct 11.

The Roskamp Institute, Sarasota, FL, United States.

Mild traumatic brain injury (mTBI) is the most common form of brain trauma worldwide. The effects of mTBI are not well-studied within the elderly population, yet older adults constitute a significant portion of all mTBI patients. Few preclinical studies have focused on the effects of mTBI, or mTBI treatments, in the aged brain, and none have explored repetitive mTBI (r-mTBI). Read More

Radiol Med 2018 Oct 25. Epub 2018 Oct 25.

SOD Radiologia Pediatrica e Specialistica, Azienda Ospedaliero Universitaria Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

Aims: To assess mean healing time of blunt spleen injuries managed nonoperatively using CEUS (contrast-enhanced ultrasound); to analyze whether spleen injury grade, subcapsular hematoma (SCH) presence, SCH grade and spleen infarct after spleen artery angioembolization could be related to healing time; and to evaluate CEUS sensitivity in diagnosing spleen injury and to assess CEUS performance in classifying spleen injury grade compared to CT.

Materials And Methods: After CT evaluation in the Emergency Department, 101 hemodynamic stable blunt spleen trauma patients (73 males; 28 females; mean age 46.4 years, range 18-92) underwent serial CEUS follow-up examinations at pre-established intervals (1, 3, 8, 15, 30, 60, 90 and 180 days after trauma), until spleen injury became no more identifiable. Read More

J Ultrasound 2018 Dec 25;21(4):315-327. Epub 2018 Oct 25.

Department of Radiology, University Hospital Careggi, L.go Giovanni Alessandro Brambilla, 3, Florence, Italy.

Splenic injuries are common emergencies in the setting of abdominal trauma, as the spleen is the second most frequently injured abdominal organ after the liver. The treatment of splenic injuries underwent a severe shift from operative to non-operative due to an increased awareness of the double physiological function, both immunological and hematological, of the spleen. This, in turn, led to an increased application of splenic preservation techniques. Read More

J Comp Pathol 2018 Oct 20;164:37-43. Epub 2018 Sep 20.

Graduate Institute of Veterinary Pathobiology, Taichung, Taiwan, Republic of China; Animal Disease Diagnostic Center, National Chung Hsing University, Taichung, Taiwan, Republic of China. Electronic address:

Fifteen splenic biopsy specimens from a total of 212 biopsy specimens and necropsy cases of domestic hamsters (Phodopus spp.) from the Division of Wild (Exotic) Animal Medicine, Veterinary Medical Teaching Hospital, National Chung Hsing University, Taiwan, collected between 2010 and 2017, were studied retrospectively. The incidence of lesions in the spleen was 7. Read More

J Cell Mol Med 2019 Jan 18;23(1):349-356. Epub 2018 Oct 18.

Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.

Background: Ionizing radiation often causes severe injuries to radiosensitive tissues, especially haematopoietic system. Novel radioprotective drugs with low toxicity and high effectiveness are required. Prolyl hydroxylases domain (PHD) inhibitors have been reported to protect against radiation-induced gastrointestinal toxicity. Read More

Eur J Trauma Emerg Surg 2018 Oct 15. Epub 2018 Oct 15.

General and Emergency Surgery Department, ASST Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.

Introduction: The majority of patients with splenic trauma undergo non-operative management (NOM); around 15% of these cases fail NOM and require surgery. The aim of the current study is to assess whether the hemodynamic status of the patient represents a risk factor for failure of NOM (fNOM) and if this may be considered a relevant factor in the decision-making process, especially in Centers where AE (angioembolization), intensive monitoring and 24-h-operating room are not available. Furthermore, the presence of additional risk factors for fNOM was investigated. Read More

Radiologia 2019 Jan - Feb;61(1):16-25. Epub 2018 Oct 9.

Área de Imagen Médica, Sección Pediatría, Hospital La Fe. Valencia, España.

The spleen is considered a "forgotten organ" by most radiologists and paediatricians despite being affected in many clinical paediatric situations. While it is the organ most often affected in paediatric abdominal trauma, non-traumatic spleen disorders are less well known. The spleen is well visualised by any imaging technique: ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI); the former is used most often in children. Read More