Search Our Scientific Publications & Authors

BMJ Case Rep 2021 Jun 23;14(6). Epub 2021 Jun 23.

Department of Surgical Gastoenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Pancreatic injuries are often overlooked in view of subtle clinical signs, and high index of suspicion is required to manage these injuries. Management strategies vary depending on the grade of injury and associated solid organ injuries and vascular injuries. Early surgery is advised in patients with duct disruption to avoid complications related to duct disruption. Read More

Neurobiol Dis 2021 Jun 18:105430. Epub 2021 Jun 18.

Departments of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA; Departments of Neurology and Psychology, The Dell Medical School and the College of Liberal Arts, University of Texas, Austin, TX 78712, USA. Electronic address:

While traumatic brain injury (TBI) is the leading cause of death and disability in children, we have yet to identify those pathogenic events that determine the extent of recovery. Neutrophils are best known as "first responders" to sites of infection and trauma where they become fully activated, killing pathogens via proteases that are released during degranulation. However, this activational state may generate substantial toxicity in the young brain after TBI that is partially due to developmentally regulated inadequate antioxidant reserves. Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211026492

Texas Tech University Health Sciences Center, El Paso, TX, USA.

Splenic rupture due to any cause is a life-threatening complication and commonly attributed to trauma. Atraumatic splenic rupture is very rarely reported, and the incidence is currently unknown. Anticoagulants and dual anti-platelet medication can increase the chances of a splenic rupture. Read More

J Med Imaging Radiat Oncol 2021 Jun 17. Epub 2021 Jun 17.

Alfred Hospital, Melbourne, Victoria, Australia.

Introduction: To compare the outcomes of proximal (pSAE) versus distal (dSAE) splenic artery embolisation for management of focal distal arterial splenic injuries secondary to blunt splenic trauma.

Method: Ethical approval was granted by the hospital research and ethics committee, Project 389/19. All patients who underwent splenic artery embolisation secondary to blunt abdominal trauma from 1 January 2009 to 1 January 2019 were reviewed. Read More

Cureus 2021 May 11;13(5):e14967. Epub 2021 May 11.

Internal Medicine; Hematology/Oncology, Veterans Affairs Hospital, Memphis, USA.

Splenic hematoma is a known complication of blunt force abdominal trauma. Traditional management of splenic hematomas has been primarily surgical. However, more recently, spleen-sparing management has been favored over surgical management for cases that meet certain criteria, with surgery now reserved for patients with complications. Read More

J Biomed Sci 2021 Jun 11;28(1):46. Epub 2021 Jun 11.

Genomics Research Center, Academia Sinica, 128, Academia Road, Sec. 2, Nankang District, Taipei, 115, Taiwan.

Dysregulated formation of neutrophil extracellular traps (NETs) is observed in acute viral infections. Moreover, NETs contribute to the pathogenesis of acute viral infections, including those caused by the dengue virus (DV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Furthermore, excessive NET formation (NETosis) is associated with disease severity in patients suffering from SARS-CoV-2-induced multiple organ injuries. Read More

Emerg Radiol 2021 Jun 11. Epub 2021 Jun 11.

University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.

Purpose: A questionnaire regarding splenic embolization in trauma was submitted to an international sample of IR faculty members, to compare their practice to the available recommendations.

Methods: A 21 multiple-choice questionnaire was sent to an international cohort of 96 IR faculty. Questions included the initial patient evaluation, embolization materials and techniques, post-procedure management, availability of an institutional protocol, and use of guidelines. Read More

Andes Pediatr 2021 Feb 22;92(1):93-98. Epub 2021 Feb 22.

Hospital Dr. Gustavo Fricke, Valparaíso, Chile.

Introduction: Fusobacterium nucleatum is an anaerobic bacillus that is part of the oral microbiota and dental pla que. This can cause local and potentially remote infections, which are exceptional in pediatrics. Ob jective: To present the case of a patient with lung injury with chest wall invasion by Fusobacterium nucleatum. Read More

J Neuroinflammation 2021 Jun 6;18(1):127. Epub 2021 Jun 6.

Neurovascular Research Laboratory, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Stroke produces a powerful inflammatory cascade in the brain, but also a suppression of the peripheral immune system, which is also called stroke-induced immunosuppression (SIIS). The main processes that lead to SIIS are a shift from a lymphocyte phenotype T-helper (Th) 1 to a Th2 phenotype, a decrease of the lymphocyte counts and NK cells in the blood and spleen, and an impairment of the defense mechanisms of neutrophils and monocytes. The direct clinical consequence of SIIS in stroke patients is an increased susceptibility to stroke-associated infections, which is enhanced by clinical factors like dysphagia. Read More

Trauma Surg Acute Care Open 2021 19;6(1):e000756. Epub 2021 May 19.

Surgery, Trauma and Burn Unit, Cook County Hospital, Chicago, Illinois, USA.

Surg Laparosc Endosc Percutan Tech 2021 Jun 10. Epub 2021 Jun 10.

International School Reduced Scar Laparoscopy, Brussels, Belgium.

Background: Minimally invasive surgery is adopted for patients presenting benign splenic cysts. Reduced port laparoscopy is an evolution of conventional laparoscopy, which can be applied for splenic cysts as well. In this video, a 3-trocar laparoscopic decapsulation of a giant nonparasitic splenic cyst is reported. Read More

Int J Mol Sci 2021 May 3;22(9). Epub 2021 May 3.

Department of Neurosurgery, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.

Based on recent findings that show that depletion of factor XII (FXII) leads to better posttraumatic neurological recovery, we studied the effect of FXII-deficiency on post-traumatic cognitive and behavioral outcomes in female and male mice. In agreement with our previous findings, neurological deficits on day 7 after weight-drop traumatic brain injury (TBI) were significantly reduced in FXII mice compared to wild type (WT) mice. Also, glycoprotein Ib (GPIb)-positive platelet aggregates were more frequent in brain microvasculature of WT than FXII mice 3 months after TBI. Read More

Int J Surg Case Rep 2021 May 21;83:105992. Epub 2021 May 21.

Escuela de Medicina y Ciencias de la Salud del Tecnológico de Monterrey, Nuevo León, México. Electronic address:

Introduction: Abdominal splenosis is a rare condition where autotransplanted ectopic spleen tissue is found in the abdominal cavity after spleen injury or splenectomy. While abdominal splenosis is mostly described as asymptomatic, bowel splenosis can present with abdominal pain, obstipation or gastrointestinal (GI) bleeding. Scarce information on bowel splenosis exists and high index of suspicion is needed for diagnosis. Read More

Int J Surg Case Rep 2021 May 12;83:105966. Epub 2021 May 12.

Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat 10430, Indonesia. Electronic address:

Introduction: Tuberculosis (TB), as a major public health concern, is affecting almost 10 million people globally. At present, diagnostic and screening efforts mainly focus on positive smear results. Therefore, the number of extra pulmonary and negative sputum TB is rising and hampering the diagnosis and treatment process due to the large number of false negatives. Read More

Mol Immunol 2021 May 26;136:8-15. Epub 2021 May 26.

Department of Trauma Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, China. Electronic address:

Background: Patients are susceptible to immunosuppression in late-stage of sepsis, in which myeloid-derived suppressor cells (MDSCs) is an important contributor. This study aims to investigate whether all-trans-retinoic acid (ATRA), which has been proved to inhibit MDSCs generation in cancer, will ameliorate sepsis-induced immuno-suppression through modulating MDSCs.

Methods: A clinically relevant "two-hit'' model of sepsis, the cecal ligation and puncture (CLP) model and secondary pneumonia model, were established in mice. Read More

Injury 2021 May 17. Epub 2021 May 17.

Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, Taiwan; Cardiovascular Department, Chang Gung Memorial Hospital, Linkou, Taiwan; Medical School, Chang Gung University, Taiwan; Graduate Institute of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan.

Purpose: The prohemorrhagic effect of aspirin may cause concern about worse prognoses when treating blunt hepatic or splenic injuries. This study investigated whether preinjury aspirin yields an increasing need for haemostatic interventions.

Methods: Admission and outpatient records were extracted from the Taiwan National Health Insurance Research Database (NHIRD) from 2003 to 2015. Read More

Free Radic Res 2021 May 27:1-16. Epub 2021 May 27.

Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences (INMAS), Defence Research and Development Organization (DRDO), New Delhi, India.

Radiation-induced hematopoietic dysfunction is one of the most common problems during unplanned radiation exposures and also in cancer patients receiving radiotherapy. Management of the hematopoietic system is necessary to promote survival against radiation. The present study was undertaken to demonstrate the protective potential of Quercetin 3 rutinoside (Q-3-R), against gamma radiation-induced hematopoietic injuries. Read More

Int J Surg Case Rep 2021 May 15;83:105970. Epub 2021 May 15.

Visceral Surgery Emergency Department 35, University hospital center Ibn Rochd, Casablanca, Morocco; Faculty of Medicine and Pharmacy, Hassan 2 university, Casablanca, Morocco.

Introduction: Post-traumatic diaphragmatic rupture is a lesion of variable severity. It is a rare and difficult to diagnose pathology, it has been found in 0.4% of all traumatized patients and in 1. Read More

Sud Med Ekspert 2021 ;64(3):48-51

Main State Center for Forensic Medicine and Forensic Expertise, Moscow, Russia.

The data on the use of mathematical modeling of spleen injury by the method of fine element analysis within the framework of a forensic medical examination of a spleen injury with the circumstances of causing injury to the victim deliberately established by the investigating authority. The result of the conducted mathematical modeling showed the adequacy of the created model and accurate reproduction of the results in spleen injury which makes it promising to introduce this method into daily expert practice. Read More

Life Sci 2021 Aug 15;278:119626. Epub 2021 May 15.

Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Aims: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The majority of sepsis-related deaths occur during late sepsis, which presents as a state of immunosuppression. Myeloid-derived suppressor cells (MDSCs) have been reported to promote immunosuppression during sepsis. Read More

Calcif Tissue Int 2021 May 17. Epub 2021 May 17.

MOE Key Laboratory for Regenerative Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.

Vasoactive intestinal peptide (VIP) as a neuromodulator and neurotransmitter played a significant role in modulating bone homeostasis. Our previous study reported an essential role of VIP in in vitro BMSCs osteogenesis and in vivo bone defect repair. VIP was also revealed to have a promoting effect on embryonic skeletal element development. Read More

Bioact Mater 2021 Dec 3;6(12):4415-4429. Epub 2021 May 3.

Department of Anatomy, State Key Laboratory of Trauma, Burn and Combined Injury, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Army Medical University (Third Military Medical University), Chongqing, 400038, China.

Cell therapy has been a promising strategy for cardiac repair after myocardial infarction (MI), but a poor ischemic environment and low cell delivery efficiency remain significant challenges. The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI, but it is unclear whether it could be used for human pluripotent stem cell (hiPSC) cultivation and provide a proper microenvironment for cell grafts against the ischemic environment. Herein, we developed a splenic extracellular matrix derived thermoresponsive hydrogel (SpGel). Read More

J Vasc Interv Radiol 2021 May 11. Epub 2021 May 11.

Department of Emergency Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Purpose: To compare embolization with laparotomy for the management of hemodynamically unstable patients with solid organ injury who responded to initial resuscitation.

Materials And Methods: Data from a Japanese nationwide trauma registry were analyzed. Included were hemodynamically unstable patients (systolic blood pressure <90 mm Hg and blood transfusion within the first 24 hours) whose initial computed tomography assessment confirmed the presence of solid organ injuries (liver and/or spleen). Read More

Immunohorizons 2021 May 12;5(5):298-306. Epub 2021 May 12.

Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany; and

Acute major tissue injury induces immune dysregulation that is characterized by the development of systemic sterile inflammation and an increased risk for opportunistic infections. Although the contribution of the innate immune system has been examined in detail, research on the impact of acute sterile tissue damage on the T cell compartment remains limited. In the current study, we used a clinically relevant mouse model for traumatic skeletal muscle injury to investigate the impact of sterile tissue damage on diverse subpopulations of CD4 Th and CD8 cytotoxic T cells in systemic and local lymphoid organs. Read More

Pediatr Radiol 2021 May 12. Epub 2021 May 12.

Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Trauma is the leading cause of morbidity and mortality in children, and rapid identification of organ injury is essential for successful treatment. Contrast-enhanced ultrasound (CEUS) is an appealing alternative to contrast-enhanced CT in the evaluation of children with blunt abdominal trauma, mainly with respect to the potential reduction of population-level exposure to ionizing radiation. This is particularly important in children, who are more vulnerable to the hazards of ionizing radiation than adults. Read More

Rev Col Bras Cir 2021 7;48:e20202777. Epub 2021 May 7.

- Hospital das Clínicas da Universidade de São Paulo, Departamento de Cirurgia - São Paulo - SP - Brasil.

The spleen is one of the most frequently affected organs in blunt abdominal trauma. Since Upadhyaya, the treatment of splenic trauma has undergone important changes. Currently, the consensus is that every splenic trauma presenting with hemodynamic stability should be initially treated nonoperatively, provided that the hospital has adequate structure and the patient does not present other conditions that indicate abdominal exploration. Read More

J Surg Res 2021 May 8;266:1-5. Epub 2021 May 8.

Division of General Surgery, Trauma and Surgical Critical Care, Yale School of Medicine, New Haven, CT.

Introduction: Anticoagulation (AC) is associated with worse outcomes after trauma in some but not all studies. To further investigate the effect of AC on outcomes in patients with splenic injury, we analyzed the Trauma Quality Programs Participant Use File (PUF) METHODS: The 2017 PUF was used to identify adult (18+ y) with all mechanisms and grades of splenic injury. Demographics, comorbidities, hospital course and outcomes were compared between AC and non-AC patients. Read More

J Clin Lab Anal 2021 Jun 6;35(6):e23801. Epub 2021 May 6.

Department of Emergency Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Background: Thrombotic complications following splenectomy have been documented. However, there has been sparse literature regarding thrombotic complications following splenic artery embolization (SAE).The objective of this study was to determine changes in coagulation and fibrinolysis and assess the thrombotic risk after SAE in patients with blunt splenic injury (BSI). Read More

Pol Przegl Chir 2021 Feb;93(2):9-15

Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Purpose: Trauma is the leading cause of mortality in people below the age of 45 years. Abdominal trauma constitutes one-fourth of the trauma burden. Scoring systems in trauma are necessary for grading the severity of the injury and prior mobilization of resources in anticipation. Read More

Radiol Case Rep 2021 Jun 18;16(6):1543-1547. Epub 2021 Apr 18.

Department of General and Visceral Surgery, Kepler University Hospital, Medical Faculty of the Johannes Kepler University, Linz, Austria.

Splenosis is a benign acquired condition, which appears after rupture of the spleen and heterotopic auto-transplantation. Mostly found as an incidental finding on cross-sectional imaging, definitive diagnosis is frequently made histologically after resection or tissue sampling. We report a case of a 36-year-old male patient who presented with increased susceptibility to infections, chronic fatigue, and a history of traumatic splenic rupture. Read More