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Anat Histol Embryol 2022 Jun 25. Epub 2022 Jun 25.

European Centre of Excellence NTIS, Faculty of Applied Sciences, University of West Bohemia, Pilsen, Czech Republic.

The spleen is a large and highly vascularized secondary lymphatic organ. Spleen injuries are among the most frequent trauma-related injuries in the abdominal region. The aims of the study were to assess the volume fractions of the main splenic tissue components (red pulp, white pulp, trabeculae and reticular fibres) and to determine the severity of splenic injury due to the experimental impact test. Read More

Ann Med Surg (Lond) 2022 Jun 24;78:103827. Epub 2022 May 24.

Kathmandu University School of Medical Sciences, Dhulikhel Hospital, Dhulikhel, 45210, Nepal.

Intra-abdominal injury due to blunt trauma accounts for 5-10% of all traumatic cases. It usually occurs secondary to motor vehicle collision, pedestrian injury, and falls. Typically these result in injury to solid abdominal organs-liver and spleen, hollow visceral organs, and rarely the abdominal vasculature. Read More

Eur J Trauma Emerg Surg 2022 Jun 21. Epub 2022 Jun 21.

Purpose: To compare the reported and observed management of UK children with blunt liver or spleen injury (BLSI) to the American Pediatric Surgical Association (APSA) 2019 BLSI guidance.

Methods: UK Paediatric Major Trauma Centres (pMTCs) undertook 1 year of prospective data collection on children admitted to or discussed with those centres with BLSI and an online questionnaire was distributed to all consultants who care for children with BLSI in those centres.

Results: All 21/21 (100%) pMTCs participated; 131 patients were included and 100/152 (65%) consultants responded to the survey. Read More

J Surg Res 2022 Jun 15;279:8-16. Epub 2022 Jun 15.

Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China. Electronic address:

Introduction: The T cell immunoglobulin and mucin domain 3 (Tim-3) mediated immunosuppressive pathway has been shown to play an essential role in the development of sepsis. However, the influence of Tim-3 blockade during sepsis and the possible effects on T cells' function remains largely unknown. Our study investigates the role of Tim-3 in cecal ligation and puncture (CLP)-induced sepsis in mice. Read More

J Surg Res 2022 Jun 15;279:17-24. Epub 2022 Jun 15.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, Colorado; Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado; Department of Surgery, Denver Health Medical Center, Denver, Colorado.

Introduction: Elevated shock index pediatric age-adjusted (SIPA) has been shown to be associated with the need for both blood transfusion and intervention in pediatric patients with blunt liver and spleen injuries (BLSI). SIPA has traditionally been used as a binary value, which can be classified as elevated or normal, and this study aimed to assess if discreet values above SIPA cutoffs are associated with an increased probability of blood transfusion and failure of nonoperative management (NOM) in bluntly injured children.

Materials And Methods: Children aged 1-18 y with any BLSI admitted to a Level-1 pediatric trauma center between 2009 and 2020 were analyzed. Read More

Physiother Theory Pract 2022 Jan 4:1-9. Epub 2022 Jan 4.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal Infantile Sciences (Dinogmi), University of Genova - Campus of Savona, Savona, Italy.

Background: The prevalence of Thoracic Pain (TP) is estimated to be low compared to other common musculoskeletal disorders such as nonspecific low back pain (LBP). Notably, compared to LBP, TP or referral pain to the thoracic area potentially may involve serious pathologies. Visceral referral of pain may present to the thoracic spine or anteriorly in the abdomen or chest. Read More

J Ethnopharmacol 2022 Jun 8;296:115447. Epub 2022 Jun 8.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Hypericum sampsonii Hance (Yuanbaocao), a traditional herbal medicine with various pharmacological properties, is traditionally used to treat diarrhea and enteritis in China for hundreds of years. Investigations have uncovered its anti-inflammatory effects and corresponding bioactive constituents in H. sampsonii, however, the mechanisms of action for the treatment of enteritis are still unclear. Read More

BMJ Open 2022 Jun 9;12(6):e058612. Epub 2022 Jun 9.

State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical Center, Army Medical University Daping Hospital, Chongqing, China

Objectives: This study analyses the clinical features and direct medical cost (DMC) of splenic injury during 2000-2013 in China.

Design: This was a cross-sectional study.

Methods: We used 'The No. Read More

Stem Cell Res Ther 2022 Jun 7;13(1):240. Epub 2022 Jun 7.

Renal Division, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, China.

Background: Primary membranous nephropathy (MN) is a kidney-specific autoimmune disease. Human embryonic stem cells-derived immunity-and-matrix regulatory cells (hESC-IMRCs) have immunoregulatory functions. We hypothesized that hESC-IMRCs might have therapeutic effects on MN and be a potential treatment in clinical practice. Read More

J Cardiothorac Surg 2022 Jun 7;17(1):145. Epub 2022 Jun 7.

General, Visceral and Transplant Surgery, Medical University of Graz, Auenbruggerplatz 29, 8036, Graz, Austria.

Background: The incidence of diaphragmatic rupture is low; however, it may be life threatening. Normally caused by blunt trauma, some cases are reported after pulmonary infections with extensive coughing. Covid 19 causes pulmonary infections and pneumonia and has been associated with weakening of the diaphragm after prolonged ventilation. Read More

Prz Gastroenterol 2022 1;17(2):103-109. Epub 2021 Oct 1.

Department of General Surgery, Paterno' Biancavilla Hospital, Paternò Biancavilla, Italy.

Diagnosis of pancreatic cancer is challenging in the initial phases because its progression is rapid. The pancreatic tail and body roughly accounts for 20-30% of all cancerous cases. The standard treatment for symptomatic benign, malignant, and premalignant diseases of the pancreatic tail and body is distal pancreatectomy. Read More

Front Immunol 2022 19;13:908618. Epub 2022 May 19.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.

Trauma/hemorrhagic shock followed by resuscitation (T/HS-R) results in multi-system inflammation and organ dysfunction, in part driven by binding of damage-associated molecular pattern molecules to Toll-like Receptor 4 (TLR4). We carried out experimental T/HS-R (pseudo-fracture plus 2 h of shock followed by 0-22 h of resuscitation) in C57BL/6 (wild type [WT]) and TLR4-null (TLR4) mice, and then defined the dynamics of 20 protein-level inflammatory mediators in the heart, gut, lung, liver, spleen, kidney, and systemic circulation. Cross-correlation and Principal Component Analysis (PCA) on data from the 7 tissues sampled suggested that TLR4 samples express multiple inflammatory mediators in a small subset of tissue compartments as compared to the WT samples, in which many inflammatory mediators were localized non-specifically to nearly all compartments. Read More

World J Clin Cases 2022 May;10(14):4535-4540

Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050000, Hebei Province, China.

Background: Regular abdominal massage can be used to treat digestive symptoms such as bloating and constipation and is reported to reduce abdominal discomfort, improve digestive function, and increase the quality of life, without serious adverse effects. Isolated pancreatic injury is rare, and most often occurs during severe trauma such as steering wheel impact injury. To our knowledge, pancreatic injury caused by massage has not yet been reported in the literature. Read More

Zhonghua Wai Ke Za Zhi 2022 Jun;60(6):509-516

Laparoscopic esophagogastric devascularization has the advantages of less trauma, less bleeding and faster recovery.In order to promote this technology in a scientific and standardized manner and to guide clinical practice, the Chinese Society of Spleen and Portal Hypertension Surgery, Chinese Medical Association, discussed and composed the "Chinese expert consensus for laparoscopic esophagogastric devascularization（2021）".This consensus adheres to the standardization and minimally invasive principles of surgical treatment of portal hypertension, and elaborates the surgical indications and contraindications, preoperative evaluation, surgical technical points and precautions, postoperative management and common complications, especially the prevention and treatment of portal vein thrombosis. Read More

Ann Med Surg (Lond) 2022 May 8;77:103516. Epub 2022 Apr 8.

Department of Surgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1076, New York, NY, 10029, USA.

Background: Splenectomy, still a commonly performed treatment for splenic injury in trauma patients, has been shown to have a high rate of complications. The purpose of this study was to identify predictors, including race and insurance status, associated with adverse outcomes post-splenectomy in trauma patients. We discuss possible explanations and methods for reducing these disparities. Read More

J Therm Biol 2022 May 30;106:103230. Epub 2022 Mar 30.

Department of Physiology and Biochemistry of Animal Nutrition, Estación Experimental del Zaidín, CSIC, Camino del Jueves s/n, 18100, Armilla, Granada, Spain. Electronic address:

The effects of heat stress and dietary betaine and zinc on growth, weight of organs and plasma biochemistry in growing Iberian pigs are of special importance. Forty Iberian barrows (43.8 kg BW) were assigned to five treatments for 28-d: 1. Read More

Life (Basel) 2022 May 6;12(5). Epub 2022 May 6.

General, Emergency and Transplant Surgery Department, ASST-Settelaghi and University of Insubria, 21100 Varese, Italy.

Liver involvement after abdominal blunt trauma must be expected, and in up to 30% of cases, spleen, kidney, and pancreas injuries may coexist. Whenever hemodynamics conditions do not contraindicate the overcoming of the ancient dogma according to which exploratory laparotomy should be performed after every major abdominal trauma, a CT scan has to clarify the liver lesions so as to determine the optimal management strategy. Except for complete vascular avulsion, no liver trauma grade precludes nonoperative management. Read More

Ann Med Surg (Lond) 2022 Jun 13;78:103564. Epub 2022 Apr 13.

Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

Background: Pancreatic trauma occurs in 0.2-2% of patients with blunt trauma and 1-12% of patients with penetrating trauma. The mortality and morbidity rates range from 9 to 34% and 30-60% respectively. Read More

BMC Pediatr 2022 May 21;22(1):300. Epub 2022 May 21.

Medical University of Vienna, Vienna, Austria.

Background: The majority of children with COVID-19 have only minor symptoms or none at all. COVID-19, on the other hand, can cause serious illness in some children, necessitating hospitalization, intensive care, and invasive ventilation. Many studies have revealed that SARS-CoV-2 affects not only the respiratory system, but also other vital organs in the body. Read More

CJEM 2022 May 18. Epub 2022 May 18.

Trauma and Emergency Services, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand.

Minerva Surg 2022 May 16. Epub 2022 May 16.

Department of Surgery, Pan'An County Peoples Hospital of Zhejiang Province, Jinhua, China.

Nanotoxicology 2022 Mar 15;16(2):247-264. Epub 2022 May 15.

Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico.

Although liposomal doxorubicin (LPD) is widely used for cancer treatment, knowledge concerning the toxicity induced by this drug in healthy organs and tissues is limited. LPD-induced toxicity studies relative to free doxorubicin (DOX) have focused on cardiotoxicity in tumor-bearing animals. On the other hand, the results on DOX-induced cardiotoxicity depending on gender are controversial. Read More

Trauma Surg Acute Care Open 2022 2;7(1):e000928. Epub 2022 May 2.

Section of Surgical Oncology, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.

Radiol Case Rep 2022 Jul 6;17(7):2367-2369. Epub 2022 May 6.

Department of Medicine and Science of Aging, Internal Medicine, 'G. D'Annunzio' University, Chieti, Italy.

Accessory spleen rupture can induce acute abdominal bleeding following minimal trauma or by atraumatic mechanisms. Spleen rupture is more frequent in pediatric patients and those affected by hematological diseases. We described the case of a 59-year-old male patient affected by hereditary spherocytosis referred to the emergency department for abdominal left side pain. Read More

BMC Microbiol 2022 May 12;22(1):128. Epub 2022 May 12.

Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Haidian District, 12 Zhongguancun Nandajie St, Beijing, 100081, People's Republic of China.

Background: Enteropathogenic Escherichia coli and Salmonella pullorum are two important groups of zoonotic pathogens. At present, the treatment of intestinal pathogenic bacteria infection mainly relies on antibiotics, which directly inhibit or kill the pathogenic bacteria. However, due to long-term irrational, excessive use or abuse, bacteria have developed different degrees of drug resistance. Read More

Theranostics 2022 21;12(7):3024-3044. Epub 2022 Mar 21.

Department of Anesthesiology, University of Virginia, Charlottesville, Virginia 22908, USA.

Splenocyte contribution to ischemic brain injury has been suggested. It is not known whether this effect is due to systemic action or direct influence in ischemic brain tissues. It is also not known how splenocytes migrate into the brain and worsen neurological outcome after brain ischemia. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 Oct 21;278:121286. Epub 2022 Apr 21.

Department of Forensic Pathology, College of Forensic Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address:

Traumatic delayed splenic rupture often follows by a "latent period" without typical symptoms after injury. During this period, though there are no obvious symptoms, the injury is still present and changing. In this study, we constructed an SD rat model of delayed splenic rupture; evaluated the model by HE staining, Perl's staining, Masson trichrome staining and immunohistochemical staining; observed the pathological changes of spleen tissue in delayed splenic rupture at different times after splenic injury; we found that pathological change of injured tissues were different from non-injured, and has phases-change patterns, it can be roughly divided into three phases: 2-7 d, 10-14 d, and 18-28. Read More

Asian J Surg 2022 May 4. Epub 2022 May 4.

Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background/objective: The present study investigated the impact of splenomegaly on the treatment outcomes of blunt splenic injury patients.

Methods: All blunt splenic injury patients were enrolled between 2010 and 2018. The exclusion criteria were age less than 18 years, missing data, and splenectomy performed at another hospital. Read More

Endocrinol Diabetes Metab Case Rep 2022 May 1;2022. Epub 2022 May 1.

Department of Endocrinology & Diabetes, Alfred Hospital, Melbourne, Australia.

Summary: Adrenal gland haemorrhage is an uncommon, yet likely under-diagnosed complication of high-impact trauma, such as motor vehicle accidents (MVA). It usually occurs with multi-trauma and is associated with additional injuries to the ribs, liver, kidney, spleen and vertebrae. Trauma cases with resultant adrenal gland injury have higher mortality rates. Read More

J Vasc Interv Radiol 2022 05;33(5):505-509

Department of Radiology, Alfred Health, Melbourne, Victoria, Australia; Department of Surgery, Monash University, Melbourne, Victoria, Australia; National Trauma Research Institute, Melbourne, Victoria, Australia. Electronic address:

Splenic artery embolization (SAE) plays a critical role in the treatment of high-grade splenic injury not requiring emergent laparotomy. SAE preserves splenic tissue, and growing evidence demonstrates preserved short-term splenic immune function after SAE. However, long-term function is less studied. Read More