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Radiol Case Rep 2019 Jul 12;14(7):787-790. Epub 2019 Apr 12.

Interventional Radiology Department, AORN "A. Cardarelli", Via A. Cardarelli 9, 80131 Naples, Italy.

Accessory spleens are often encountered in radiologic studies and they are not usually associated with symptoms. They could arise from autotransplantation of splenic tissue after splenic trauma or splenectomy (splenosis) [1]. In this case we describe a woman treated for splenectomy 20 years before and subsequently for adhesions, that suffered sudden left upper abdominal quadrant pain, weakness, and pale color. Read More

World J Hepatol 2019 Mar;11(3):318-329

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.

Background: Most patients with hydatid cysts are asymptomatic, and they are diagnosed incidentally during radiological evaluations performed for other reasons. However, some patients develop symptoms and complications due to cyst size, location, and the relationship between the cyst and adjacent structures. The most serious complications that can occur are rupture of the cysts into the biliary tract, vascular structures, hollow viscus, and peritoneal cavity. Read More

J Surg Case Rep 2019 Mar 29;2019(3):rjz021. Epub 2019 Mar 29.

Trauma Surgery and Surgical Critical Care, Geisinger Wyoming Valley Hospital, Wilkes-Barre, PA 18711, USA.

Splenic rupture in the absence of major trauma is a rare occurrence, which may occur by idiopathic means or a specific pathologic process. One such condition, amyloidosis, involves the extracellular deposition of abnormally folded 'amyloid' protein, which can affect the spleen. Protein infiltration in the organ may cause splenomegaly and potentially capsular rupture in advanced cases. Read More

Evid Based Complement Alternat Med 2019 3;2019:8497980. Epub 2019 Mar 3.

Wonkwang University, College of Pharmacy, Department of Oriental Pharmacy & Wonkwang Oriental Medicines Research Institute, Iksan, Jeonbuk, Republic of Korea.

Myrrh essential oil (MEO) is widely used as remedies for the different human ailment in different parts of the world. The misuse of this natural product in higher doses may lead to fever, inflammation, and liver and kidney problems. In this study, we performed the acute and subacute toxicity analysis of MEO in mice model after subcutaneous injection and evaluated the safe dose to prevent the possible risk and side effects. Read More

Cureus 2019 Jan 19;11(1):e3922. Epub 2019 Jan 19.

Radiology, Aga Khan University Hospital, Karachi, PAK.

Objective The aim of this study was to describe the outcome of the use of interventional radiological procedures (IRP) (angioembolization) in critically injured children. Methods A retrospective review of medical records of all children who underwent an IRP from January 2010 to December 2015 was done. Data were collected on a structured proforma and results are presented as mean with standard deviation and frequency with percentages. Read More

J Surg Res 2019 Mar 22;240:60-69. Epub 2019 Mar 22.

Division of Trauma and Critical Care and Acute Care Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Background: Racial, ethnic, and socioeconomic disparities have been shown to exist in trauma patients. Management of blunt splenic injuries (BSIs) can include splenectomy, embolization, or nonoperative management. This study assesses the effect of race and insurance status on outcomes in patients after blunt splenic trauma. Read More

Neurobiol Aging 2019 Feb 20;77:194-206. Epub 2019 Feb 20.

Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

After traumatic brain injury (TBI), individuals aged over 65 years show increased mortality and worse functional outcomes compared with younger persons. As neuroinflammation is a key pathobiological mechanism of secondary injury after TBI, we examined how aging affects post-traumatic microglial responses and functional outcomes. Young (3-month-old) and aged (18-month-old) male C57Bl/6 mice were subjected to moderate-level controlled cortical impact or sham surgery, and neurological function was evaluated. Read More

Int Immunopharmacol 2019 Mar 16;71:115-131. Epub 2019 Mar 16.

Environment and Non-Communicable Disease Research Center, Key Laboratory of Arsenic-related Biological Effects and Prevention and Treatment in Liaoning Province, School of Public Health, China Medical University, Shenyang 110122, China. Electronic address:

The immunomodulatory properties of arsenic are nowadays supposed be associated with pathological injuries of this toxicant and the details have not been clarified. Our objective was to explore inflammation, differentiation of diverse T cell subsets, as well as the phenotypic molecules and functions of dendritic cells (DCs) by chronic arsenic exposure in vivo. We exposed different concentrations of arsenic (0, 0. Read More

Scand J Surg 2019 Mar 4:1457496919833220. Epub 2019 Mar 4.

Abdominal Center, Meilahti Hospital, University of Helsinki, Helsinki, Finland.

Background And Aims:: Today, a significant proportion of solid abdominal organ injuries, whether caused by penetrating or blunt trauma, are managed nonoperatively. However, the controversy over operative versus nonoperative management started more than a hundred years ago. The aim of this review is to highlight some of the key past observations and summarize the current knowledge and guidelines in the management of solid abdominal organ injuries. Read More

Front Pharmacol 2019 15;10:54. Epub 2019 Feb 15.

Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové, Czechia.

Endotoxemia is associated by dysregulated apoptosis of immune and non-immune cells. We investigated whether simvastatin has anti-apoptotic effects, and induces hepatocytes and lymphocytes survival signaling in endotoxin-induced liver and spleen injuries. Wistar rats were divided into the groups pretreated with simvastatin (20 or 40 mg/kg, orally) prior to a non-lethal dose of lipopolysaccharide (LPS), the LPS group, and the control. Read More

J Emerg Med 2019 Apr 28;56(4):437-440. Epub 2019 Feb 28.

Department of Emergency Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.

Background: Colonoscopy is a frequently performed medical procedure; complications associated with this procedure often present to the emergency department (ED). Splenic laceration is a rare but life-threatening complication of colonoscopy. We report the unique case of a patient with a splenic laceration who presented after a recent colonoscopy and had no history of trauma. Read More

Front Immunol 2019 12;10:106. Epub 2019 Feb 12.

Laboratory of Translational Medicine, School of Life Science, University of Hyderabad, Hyderabad, India.

Accidental exposure to lethal doses of Gamma radiation leads to the systemic inflammatory syndrome which causes mortality. In view of this, management of hemopoietic syndrome by modulating pro-inflammatory response in clinically manageable time period seems to be the most appropriate strategy for encountering radiation induced damage and recovery. As both tissue and peripheral macrophages are critical for the management of radiation induced injuries, we have unraveled the immunomodulatory potential of radioprotective formulation (G-003M) on peripheral macrophages populations in this study. Read More

Forensic Sci Int 2019 Apr 22;297:384-387. Epub 2019 Feb 22.

Department of Forensic Pathology, LabPLUS, Auckland City Hospital, Auckland 1148, New Zealand.

The spleen is only uncommonly investigated in the forensic setting. Thorough examinations are performed in some specific situations such as splenic trauma (including iatrogenic trauma from cardiopulmonary resuscitation attempts), anaphylaxis, drowning, and sepsis-related deaths. The aim of this review is to present the available literature focusing on a few selected splenic diseases as well as forensic investigations performed on the spleen in order to summarize the most frequent situations in which this routinely unexplored organ may merit more extensive examination. Read More

Heart Surg Forum 2019 01 30;22(1):E024-E026. Epub 2019 Jan 30.

Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, Serbia.

The paper presents collaboration of an abdominal surgeon and heart team in deciding upon surgical management of a patient with the implanted left ventricular assist device, who has undergone emergency abdominal operation for spleen rupture. The paper focuses on the significance of prompt diagnostics, clinical challenges of hemodynamic and anticoagulant treatment, abdominal organ exposure along the placed left ventricular assist device driveline, identification of vascular structures in conditions of continuous blood flow, and reconstruction of the surgical wound in the driveline projection. Read More

Biomed Pharmacother 2019 Apr 20;112:108609. Epub 2019 Feb 20.

Translational Medicine Center of Sepsis, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China; Department of Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China; Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, People's Republic of China. Electronic address:

Background: The importance of sepsis-induced immunosuppression and its contribution to mortality has recently emerged. In this study we examined the effects of Tanshinone II-A (TSN), a widely used traditional Chinese medicine, on immunosuppression in experimental peritonitis induced septic mice.

Materials And Methods: Sepsis was achieved by means of cecal ligation and puncture (CLP). Read More

Med Ultrason 2019 Feb;21(1):16-21

Department of Radiologic Sciences, SOD Clinica di Radiologia, d'Urgenza e dell'Area Oncologica, Università Politecnica delle Marche, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy.

Aims: To assess contrast enhanced ultrasound (CEUS) performance in the prediction of non-operatively managed blunt spleen injuries requiring only observation and monitoring during follow-up and to evaluate if CEUS accuracy was higher than conventional ultrasound (US) in this field.

Material And Methods: In 112 hemodynamic stable blunt spleen trauma patients, CEUS was performed for follow-up after computed tomography evaluation in the emergency department. CEUS and US performance were assessed considering as true negative cases patients that had not underwent interventional or surgical treatment during follow-up and were assessed as negative for splenic complications respectively by CEUS or US examinations. Read More

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):260-264

Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.

The 5q35.2-q35.3 duplication phenotype is characterized by growth delay, microcephaly, mental retardation and delayed bone aging. Read More

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of Pediatric Surgery, University of Tennessee Health Science Center, Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN. Electronic address:

Purpose: The American Pediatric Surgical Association (APSA) guidelines for the treatment of isolated solid organ injury (SOI) in children were published in 2000 and have been widely adopted. The aim of this systematic review by the APSA Outcomes and Evidence Based Practice Committee was to evaluate the published evidence regarding treatment of solid organ injuries in children.

Methods: A comprehensive search strategy was crafted and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were utilized to identify, review, and report salient articles. Read More

Kyobu Geka 2019 Feb;72(2):104-107

Division of Cardiovascular Surgery, Tohoku University, Sendai, Japan.

Extraperitoneal approach is commonly employed for thoracoabdominal aortic repair via Stoney incision. It is supposedly rare to encounter abdominal visceral bleeding during that procedure. However, the spleen may spontaneously adhere to the adjacent peritoneum, which could induce incidental injury to the spleen by its anterior mobilization during extraperitoneal approach. Read More

Scand J Trauma Resusc Emerg Med 2019 Feb 14;27(1):19. Epub 2019 Feb 14.

, Yerevan, Armenia.

In bacteremia the majority of bacterial species are killed by oxidation on the surface of erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing bacteria overcome this mechanism of human innate immunity by versatile respiration, production of antioxidant enzymes, hemolysins, exo- and endotoxins, exopolymers and other factors that suppress host defense and provide bacterial survival. Entering the bloodstream in different forms (planktonic, encapsulated, L-form, biofilm fragments), they cause different types of sepsis (fulminant, acute, subacute, chronic, etc. Read More

Life Sci 2019 Mar 6;221:47-55. Epub 2019 Feb 6.

Institute of Microcirculation, Key Laboratory of Microcirculation, Ministry of Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

Background: Spinal cord injury (SCI) disturbs the autonomic nervous system and induces dysfunction or failure of multiple organs. The systemic microcirculation disturbance that contributes to the complications associated with SCI remains to be clarified.

Methods: We used male mice (29-32 g) and modified weight-drop injury at T10 to evaluate the systemic microcirculation dysfunction during the first 2 weeks after SCI. Read More

IBRO Rep 2019 Jun 11;6:74-86. Epub 2019 Jan 11.

A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

Inflammation is a prominent feature of the neuropathology of amyotrophic lateral sclerosis (ALS). Emerging evidence suggests that inflammatory cascades contributing to the disease progression are not restricted to the central nervous system (CNS) but also occur peripherally. Indeed, alterations in T cell responses and their secreted cytokines have been detected in ALS patients and in animal models of ALS. Read More

Asian Cardiovasc Thorac Ann 2019 Mar 31;27(3):234-235. Epub 2019 Jan 31.

2 American University of Beirut Medical Center, Beirut, Lebanon.

Cureus 2018 Nov 17;10(11):e3604. Epub 2018 Nov 17.

General Surgery, Jinnah Postgraduate Medical College, Karachi, PAK.

Introduction Abdominal injuries are responsible for 10% of the mortalities due to trauma. Delays in early diagnosis or misdiagnoses are two major reasons for the mortality and morbidity associated with abdominal trauma. The objectives of this study were to determine the frequency of visceral injuries in patients with abdominal trauma and compare the frequency of visceral injuries in patients with blunt and penetrating abdominal trauma. Read More

J Interferon Cytokine Res 2019 Feb 24;39(2):95-105. Epub 2019 Jan 24.

1 National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi Province, China .

Our study aimed to investigate the histologic and immunological changes of portal hypertension (PH) pre- and postsplenectomy in hepatitis B virus (HBV)-related cirrhosis. Peripheral blood samples were obtained from 30 patients with HBV-related cirrhosis and PH at pre- and postsplenectomy time points and from 15 healthy subjects. Spleen tissue specimens were collected from 15 of the patients with HBV-related cirrhosis and from 8 control patients who had undergone splenectomy due to trauma. Read More

Eur J Pediatr 2019 Apr 21;178(4):491-495. Epub 2019 Jan 21.

Division of Neonatology, Careggi University Hospital of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 2500 to 5000 infants. The use of lung ultrasound (LUS) for its diagnosis has been reported in only two case reports. The aim of this study was to report the LUS pattern of CDH in a case series of infants with respiratory distress. Read More

J Pediatr Surg 2018 Dec 5. Epub 2018 Dec 5.

Service de Chirurgie Générale Digestive, Cancerologique, Bariatrique et Métabolique, Hôpital Avicenne, Bobigny, France; Laboratoire d'Ethique Médicale et de Médecine Légale, Université Paris "Descartes", Paris, France.

Background/purpose: In order to avoid consequences of total splenectomy (including severe postsplenectomy sepsis), partial splenectomy (PS) is increasingly reported. Without guidelines and indications concerning a rarely-indicated procedure, a review of literature should be an asset.

Methods: A systematic review of all PSs from 1960 to December 2017 was performed, with special focus on surgical indications, sites of resection, approaches and techniques of vascular dissection and parenchymal section/hemostasis of the spleen, perioperative morbidity/mortality, including complications compelling to perform total splenectomy. Read More

Acta Biomed 2019 Jan 15;89(4):505-512. Epub 2019 Jan 15.

.

Aim: In our study we investigated characteristics and degree of intra-abdominal solid organ injuries according to tomographic imaging in pediatric patients who presented to our emergency clinic with possible abdominal injuries and to whom US and/or abdominal tomography were applied.

Materials And Methods: 1066 pediatric patients were included in the study. The age, gender, injury localization, injury type, injury mechanism, abdominal US and CT results, and treatment specifics of patients were evaulated. Read More

Emergencias 2019 Ene;31(1):15-20

Servicio de Cirugía General y Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Objectives: To describe the abdominal injuries treated in our hospital. We assessed the behavior and reliability of prognostic scales, analyzing the correlations between them and therapeutic decisions and outcomes.

Material And Methods: Retrospective study including all patients with major abdominal injuries admitted to our hospital between 2009 and 2015. Read More

Rozhl Chir Winter 2018;97(12):546-550

Introduction: Despite current efforts at the most conservative approach possible to splenic injury, splenectomy remains a relatively common surgical procedure. Indications for splenectomy, however, are not limited to spleen injury. In senior patients in particular, non-traumatic reasons for splenectomy becomemore frequent. Read More

Stem Cell Res Ther 2019 Jan 11;10(1):22. Epub 2019 Jan 11.

Institute of Liver Diseases, Affiliated Hospital of Jining Medical University, Jining, 272067, People's Republic of China.

Background: Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important. Human liver stem cells (HLSCs) are early undifferentiated cells that have been implicated in the regeneration and functional reconstruction of the liver. Read More

Scand J Trauma Resusc Emerg Med 2019 Jan 11;27(1). Epub 2019 Jan 11.

Division of Trauma and Emergency Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan City, Taiwan.

Background: The long-term treatment trends of splenic injuries can provide guidance when treating trauma patients. The nonoperative management (NOM) of splenic injuries was introduced in early 1989. After decades of development, it has proven to be safe and is now the primary treatment choice worldwide. Read More

JSLS 2018 Oct-Dec;22(4)

Minimally Invasive Surgery, Department of Surgery, Howard University Hospital, Washington, DC USA.

Background And Objectives: The use of laparoscopy in the trauma setting is gaining momentum, with more therapeutic procedures being performed. We evaluated the use of laparoscopic splenectomy among trauma patients with data from the National Trauma Database. We compared outcomes for trauma patients undergoing laparoscopic (LS) versus open splenectomy (OS). Read More

Ann R Coll Surg Engl 2019 Mar 3;101(3):176-179. Epub 2019 Jan 3.

Northumbria Healthcare NHS Foundation Trust , UK.

Introduction: The aim of this study was to review the experience of general surgeons performing splenectomy in a district general hospital. The outcomes are discussed together with potential reasons for the increasing rarity of the procedure.

Methods: A retrospective cohort study was carried out of all patients undergoing splenectomy (as identified by a single trust pathology department on receipt of splenic samples) between 1 January 2000 and 1 May 2017. Read More

Ann Surg 2018 Dec 20. Epub 2018 Dec 20.

Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: The primary objective of this study was to evaluate the utility, clinical impact, and work flow of a new trauma hybrid operating theater.

Summary Background Data: The potential utility and clinical benefit of hybrid operating theaters are increasingly postulated. Unfortunately, the clinical outcomes and efficiencies of these environments remain unclear. Read More

Int J Surg Case Rep 2019 22;54:113-115. Epub 2018 Nov 22.

Division of Trauma, Bronx, NY, USA; School of Medicine, City University of New York, New York, NY, USA; College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA. Electronic address:

Introduction: Large bowel obstruction (LBO) warrants prompt evaluation and management. Although causes of LBO are most commonly intrinsic to the colon (e.g. Read More

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Nov;34(11):961-968

Institute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China. *Corresponding author, E-mail:

Objective To study the effect of CD11b agonist leukadherin-1 (LA1) on the aggregation and immunosuppressive function of myeloid-derived suppressor cells (MDSCs) and its therapeutic effect on the condition of endotoxic shock mice. Methods The percentages of MDSCs , granulocytic myeloid-derived suppressor cells(G-MDSCs)and monocytic myeloid-derived suppressor cells(M-MDSCs)in spleen were detected by flow cytometry, after C57BL/6 female mice were injected of LA1 to activate through abdominal cavity for 12 hours and 48 hours. MDSCs were induced from the femur and tibia of C57BL/6 female mice in vitro. Read More

J Trauma Acute Care Surg 2019 Jan;86(1):86-91

From the Department of Surgery, The Children's Hospital at OU Medical Center (P.M.G., P.M, Z.S., R.W.L.), Oklahoma City, Oklahoma; Pediatric Trauma Center, Dell Children's Medical Center (N.M.G., K.A.L., D.W.T.), Austin, Texas; Department of Pediatric Surgery, Children's Healthcare of Atlanta (A.B.), Atlanta, Georgia; Level I Pediatric Trauma Center, Phoenix Children's Hospital (M.E.L., C.S.L., D.M.N., D.J.O.), Phoenix, Arizona; Department of Pediatric Surgery, Arkansas Children's Hospital (R.T.M.), Little Rock, Arkansas; Department of Pediatric Surgery, Le Bonheur Children's Hospital (J.W.E.), Memphis, Tennessee; Pediatric Surgery Department, Children's Medical Center (A.C.A.), Dallas, Texas; Department of Pediatric Surgery, Akron Children's Hospital (T.A.P.), Akron, Ohio; Pediatric Surgery, American Family Children's Hospital (C.W.L.), Madison, Wisconsin; Pediatric Surgery, Mercy Children's Hospital (S.D.S.P.), Kansas City, Missouri.

Background: Focused Abdominal Sonography for Trauma (FAST) examination has long been proven useful in the management of adult trauma patients, however, its utility in pediatric trauma patients is not as proven. Our goal was to evaluate the utility of a FAST examination in predicting the success or failure of nonoperative management (NOM) of blunt liver and/or spleen (BLSI) in the pediatric trauma population.

Methods: A retrospective analysis of a prospective observational study of patients younger than 18 years presenting with BLSI to one of ten Level I pediatric trauma centers between April 2013 and January 2016. Read More

BMC Surg 2018 Dec 20;18(1):119. Epub 2018 Dec 20.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, No.166 Da Xuedong Road, Nanning, 530007, Guangxi, China.

Background: Spleen leaves its normal anatomical position and appears in other locations, which is called ectopic spleen. It is most commonly found in the abdomen or pelvis with seeding of the peritoneum, omentum or mesentery. A few of cases of thoracic splenosis associated with traumatic diaphragmatic rupture have been reported. Read More

World J Clin Cases 2018 Dec;6(15):1047-1052

Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.

This report describes a 52-year-old male patient with blunt abdominal traumatic rupture of the spleen due to injuries sustained in an automobile accident. Following splenectomy, the patient developed a gastric fistula. He underwent a long period of conservative treatment, including antibiotics and total parenteral nutrition, which was ineffective. Read More

Eur Surg 2018 20;50(6):285-298. Epub 2018 Jul 20.

1Department of Visceral, Transplantation and Thoracic Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.

Background: Non-operative management (NOM) of blunt hepatic and splenic injuries has become popular in haemodynamically stable adult patients, despite uncertainty about efficacy, patient selection, and details of management. Up-to-date strategies and practical recommendations are presented.

Methods: A selective literature search was conducted in PubMed and the Cochrane Library (1989-2016). Read More

Wideochir Inne Tech Maloinwazyjne 2018 Dec 30;13(4):460-468. Epub 2018 May 30.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: Throughout our 20 years of experience, we have used several different techniques for laparoscopic splenectomy (LS). However, two methods have been used most frequently: "vessels first" and "hilar transection".

Aim: To evaluate the outcomes of LS performed with these two different approaches. Read More

Mol Med Rep 2019 Feb 4;19(2):841-850. Epub 2018 Dec 4.

Spleen, Stomach and Hepatobiliary Department, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, Henan 450004, P.R. China.

α‑lipoic acid (ALA) is a naturally occurring antioxidant with protective effects against various hepatic injuries. The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis. The widely used liver cirrhosis rat model was established via an intraperitoneal injection of 2 mg/kg 50% CCl4, three times/week for 8 weeks. Read More

Radiat Res 2019 02 6;191(2):162-175. Epub 2018 Dec 6.

a Columbia University Medical Center, New York, New York.

Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that may be induced by high-energy galactic cosmic rays encountered on interplanetary space missions. To collect data on the effects of space radiation on the human hematopoietic system in vivo, we used a humanized mouse model. Read More

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):569-574

Department of Pediatric Surgery, Marmara University Faculty of Medicine, İstanbul-Turkey.

Background: Although a nonoperative treatment approach is preferred for blunt liver and spleen trauma in childhood, there are significant differences between clinics in the algorithms used. The approach to high-grade liver and spleen injury is still controversial, particularly as grade V liver and spleen injuries are not included in the American Pediatric Surgical Association guideline. The aim of this study was to present experience with a non-operative treatment approach to children with high-grade liver and spleen injuries. Read More

Int J Burns Trauma 2018 20;8(5):117-125. Epub 2018 Oct 20.

Nuclear Medicine Department, Isfahan University of Medical Sciences Isfahan, IR Iran.

Background: The most prevalent method of treating splenic injury is by splenectomy. This method is followed by postoperative complications. Therefore, less invasive procedures such as splenic angioembolization are introduced. Read More

BJS Open 2018 Dec 10;2(6):426-432. Epub 2018 Jul 10.

Department of General Surgery, Chang Gung Memorial Hospital Chang Gung University Tao-Yuan City Taiwan.

Background: The aim of this study was to analyse outcomes of spleen-preserving (SPDP) and spleen-sacrificing (SSDP) distal pancreatectomy in adults with severe blunt pancreatic injuries.

Methods: This was an observational study of adult patients who underwent distal pancreatectomy for grade III or IV blunt pancreatic injury between 1991 and 2015. Outcomes of SPDP and SSDP were compared. Read More

Malar J 2018 Dec 4;17(1):448. Epub 2018 Dec 4.

Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease, including fatal outcomes. Spontaneous splenic rupture is a rare, but severe complication of malaria and has not been reported previously for knowlesi malaria. Read More

Radiol Med 2019 Mar 28;124(3):170-175. Epub 2018 Nov 28.

Department of Radiological Sciences, Azienda Ospedaliero Universitaria Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

Introduction: We describe the use of contrast-enhanced ultrasound (CEUS) in the diagnosis of delayed splenic vascular injury (DSVI) and active extravasation (DAE) during spleen injury follow-up. CEUS might be used instead of contrast-enhanced computed tomography (CECT) during spleen injury follow-up in order to reduce radiation exposure.

Objective: Assess diagnostic comparability between CEUS and CECT in the evaluation of DSVI and DAE during spleen injury follow-up. Read More

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):815-820

Trauma Research Center, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China.

To explore influence of vagus nerve on multiple organ function and immune reaction of T lymphocytes in septic rats. Forty Sprague-Dawley rats were divided into sham injury group, sepsis group, vagus nerve stimulation (VNS) group, and vagotomy (VGX) group, according to the random number table, with 10 rats in each group. Rats in sepsis group, VNS group, and VGX group were inflicted with sepsis by cecal ligation and puncture (CLP). Read More