897 results match your criteria Spiradenoma

Giant vascular eccrine spiradenoma: the first case in the scrotum and review of the literature author.

Diagn Pathol 2021 Apr 30;16(1):37. Epub 2021 Apr 30.

College of Stomatology, Chongqing Medical University, Songshi Bei Road 426, Yubei District, 401147, Chongqing, China.

Background: Giant vascular eccrine spiradenoma is a rare variant of eccrine spiradenoma. It is different from the eccrine spiradenoma in its larger size and greater degree of vascularity. It is often clinically confusedwith a vascular or malignant tumor. Read More

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A rare case of malignant eccrine spiradenoma mimicking carcinosarcoma.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):398-401

Department of Surgery, M R Bangur Super Speciality Hospital, Kolkata, West Bengal, India.

Malignant eccrine spiradenoma is an extremely rare neoplasm of adnexal origin. It almost always originates from a preexisting long standing eccrine spiradenoma. We present a case of malignant eccrine spiradenoma arising from benign counterpart and having both carcinomatous and sarcomatous differentiation. Read More

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Ultrasonographic features of eccrine spiradenoma: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25469

Department of Ultrasound, Hebei General Hospital, Shijiazhuang, Hebei, China.

Rationale: Eccrine spiradenoma (ES) is a rare benign skin adnexal tumor originating from eccrine sweat glands. The features of ES on ultrasonography (US) have received little attention. Therefore, we report the sonographic findings in a case of an ES that originated from the abdominal wall and discuss the previously reported cases. Read More

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Eccrine spiradenoma: a rare adnexal tumour with atypical presentation: A case report.

J Pak Med Assoc 2021 02;71(2(A)):553-555

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

First described in 1934, eccrine spiradenoma (ES) is a rare, benign adnexal tumour arising from eccrine sweat glands. It commonly presents as a slow-growing nodule on the upper trunk, and head and neck region, mostly in the age bracket of 15-35 years, with no gender preference. While no established guidelines exist for optimal management of malignant ES, some therapies have been studied. Read More

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February 2021


An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5.

Department of Dermatological Surgery, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

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Eccrine Hidradenoma of the Nasal Vestibule: A Rare Clinical Entity.

Ear Nose Throat J 2021 Feb 15:145561321995018. Epub 2021 Feb 15.

Department of Otorhinolaryngology and Biomedical Research Institute, 220312Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.

Eccrine hidradenoma is a relatively rare benign tumor of sweat gland origin but with possible malignant transformation. It usually consists of solitary, well-demarcated papules or nodules covered with normal skin. Common sites of involvement are the scalp, face, limbs, and anterior trunk. Read More

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February 2021

Multiple rubbery nodules on the scalp.

JAAD Case Rep 2021 Feb 5;8:80-82. Epub 2021 Jan 5.

DiSSal Section of Dermatology, San Martino Polyclinic Hospital IRCCS, University of Genoa, Genoa, Italy.

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February 2021

Malignant Eccrine Adenoma With Sarcomatous (Heterologous) Components: Report of a Rare Skin Adnexal Neoplasm With Literature Review.

Cureus 2020 Dec 30;12(12):e12390. Epub 2020 Dec 30.

Histopathology, Aga Khan University Hospital, Karachi, PAK.

Malignant eccrine spiradenoma (MES) is an exceedingly rare skin adnexal tumor that arises from pre-existing benign eccrine spiradenoma (BES). MES tumors show a wide spectrum of morphological features, posing a diagnostic challenge to the pathologist. Sarcomatous (heterologous) elements are seen in a few of these tumors, further complicating the morphological picture. Read More

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December 2020

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.

ANZ J Surg 2021 Feb 1. Epub 2021 Feb 1.

Monash University Endocrine Surgery Unit, Alfred Hospital, Melbourne, Victoria, Australia.

Background: Spiradenocarcinoma is a rare skin adnexal neoplasm that may behave aggressively. It is often associated with a benign slow-growing spiradenoma that has undergone malignant transformation. Given the paucity of cases in the literature, there is a lack of consensus on treatment. Read More

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February 2021

Malignant Eccrine Spiradenoma of the External Auditory Canal: A Case Report and Literature Review.

Front Oncol 2020 5;10:574112. Epub 2021 Jan 5.

Department of Radiation Oncology, Yantai Yuhuangding Hospital, Yantai, China.

Spiradenocarcinoma, or malignant eccrine spiradenoma (MES), is a rare sweat gland tumor originating from eccrine sweat glands. To the best of our knowledge, only two cases of MES of the external auditory canal have been reported to date. Here, we report a third case of MES located in the external auditory canal. Read More

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January 2021

Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics.

Am J Dermatopathol 2020 Dec 1. Epub 2020 Dec 1.

Departments of Pathology.

Basal cell carcinoma (BCC) is the most common skin cancer, and it has numerous histologic mimics with variable prognoses and treatments. Although some immunohistochemical stains can be used for the differential diagnosis of BCC, variability and overlap in results can complicate their interpretation. Immunohistochemical staining for glioma-associated oncogene-1 (Gli-1) was performed on 26 nodular BCCs, 22 infiltrative BCCs, 9 basaloid squamous cell carcinomas, 12 desmoplastic trichoepitheliomas, 19 Merkel cell carcinomas, 11 sebaceous carcinomas, 10 cylindromas, 14 spiradenomas, 12 adenoid cystic carcinomas (AdCC), and 1 solitary trichoepithelioma. Read More

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December 2020

Brooke-Spiegler Syndrome With Cervical Spine Lesion.

Cureus 2020 Oct 16;12(10):e10982. Epub 2020 Oct 16.

Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, USA.

Brooke-Spiegler syndrome (BSS) is a rare hereditary autosomal dominant disorder with variable phenotypic expressivity that results in a variety of benign cutaneous face, scalp, and neck tumors with a histology profile of cylindroma, spiradenoma and trichoepithelioma. Reports of lymph node and distant metastasis are scarce. We present the first case of Brooke-Spiegler syndrome with metastasis to the cervical spine. Read More

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October 2020

Spiradenoma of the breast: a rare diagnostic pitfall in the evaluation of solid-basaloid breast lesions with a dual cell population.

Virchows Arch 2020 Nov 5. Epub 2020 Nov 5.

Department of Pathology, Japanese Red Cross Okinawa Hospital, Okinawa, Japan.

Breast spiradenoma is extremely rare, with only 4 cases reported previously. We describe an instructive case of breast spiradenoma resembling adenoid cystic carcinoma (AdCC). A 71-year-old woman underwent excisional biopsy of a breast mass after a conclusive diagnosis was unable to be obtained from core needle biopsy showing an AdCC-like pattern. Read More

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November 2020

Clear Cell Hidradenoma of the Breast Diagnosed on a Core Needle Biopsy: A case report and review of the literature.

Sultan Qaboos Univ Med J 2020 Aug 5;20(3):e357-e361. Epub 2020 Oct 5.

Department of General Surgery, Sultan Qaboos University Hospital, Muscat, Oman.

Clear cell hidradenoma (CCH) is a tumour originating from the eccrine sweat glands. It usually presents in the limbs, axilla or trunk. CCH of the breast is rare and can present as a cystic lesion in the breast that can be easily misdiagnosed as malignancy. Read More

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Metaplastic spiradenocarcinoma: Report of two cases with sarcomatous differentiation.

J Cutan Pathol 2021 Mar 5;48(3):384-389. Epub 2020 Nov 5.

Dermatopathology Friedrichshafen, Friedrichshafen, Germany.

Spiradenocarcinoma (SC) is a very rare malignant skin adnexal tumor with sweat gland differentiation that develops from a pre-existing spiradenoma, cylindroma, or hybrid tumor called spiradenocylindroma, or arises de novo. We present two exceptionally rare SC cases showing sarcomatous differentiation; we also discuss the clinicopathologic features of SC, as well as its differential diagnoses and available therapeutic modalities. Given the aggressive behavior of SC, rapid diagnosis and complete removal of the tumor with tumor-free margins is mandatory. Read More

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Unusual skin tumour with a large cystic component.

J Clin Pathol 2021 Mar 12;74(3):e5. Epub 2020 Aug 12.

Honorary President, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan.

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MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases.

Am J Dermatopathol 2021 Apr;43(4):278-283

Department of Dermatology, Hyogo Cancer Center, Akashi, Japan.

Abstract: Adenoid cystic carcinoma (ACC) is an infiltrating carcinoma composed of 2 cell types, myoepithelial and ductoglandular epithelial cells. Although approximately 70% of ACC exhibit translocations of the MYB proto-oncogene or MYB proto-oncogene like 1 (MYBL1), expression of MYB is known to be limited in myoepithelial cells. We investigated the histopathologic and genetic characteristics of ACC in 6 primary cutaneous cases. Read More

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Are there EWSR1 rearranged cutaneous hidradenomas and mucoepidermoid carcinomas of salivary glands? A FISH study and review of the literature.

Pol J Pathol 2020 ;71(2):99-106

Department of Pathology, Abdurrahman Yurtaslan Oncology Education and Research Hospital, Ankara, Turkey.

MAML2 rearrangements have been previously described for hidradenomas and muco-epidermoid carcinomas (MEC). However, one report showed EWSR1 rearrangement in both tumours. In this study, EWSR1 and MAML2 translocation were investigated in hidradenomas and MECs. Read More

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October 2020

[Skin spiradenoma of breast: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):738-740

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

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Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings.

Int J Surg Pathol 2020 Oct 4;28(7):711-720. Epub 2020 May 4.

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

. The expression of terminal deoxynucleotidyl transferase (TdT) in myoepithelial cells (MECs) within the breast was recently incidentally observed in our routine practice. This study aimed to elucidate the expression of TdT in MECs. Read More

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October 2020

Case of spiradenocylindroma expressed hair follicle stem cell markers.

J Dermatol 2020 Jun 7;47(6):e246-e248. Epub 2020 Apr 7.

Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

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Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions.

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

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February 2020

Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV.

Diagn Pathol 2020 Mar 14;15(1):24. Epub 2020 Mar 14.

Pathology Department, Erasme University Hospital, Université Libre de Bruxelles, CP 610, Route de Lennik, 808, 1070, Brussels, Belgium.

Background: Malignant eccrine spiradenoma is one of the rarest sweat-gland tumors. Here, we describe a rare case of low grade malignant eccrine spiradenoma located at the vulva.

Case Presentation: The vulvar lesion was described as a mass measured 3. Read More

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Apocrine Hidradenoma and Adenomyoepithelioma: Entities on a Biological Continuum of Adnexal Neoplasia.

Am J Dermatopathol 2020 Jul;42(7):491-497

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone, Halifax, Nova Scotia, Canada.

Apocrine hidradenomas (AH) once believed to harbor myoepithelial cells are now considered pure epithelial neoplasms. They are categorized separately from adenomyoepitheliomas which consist of apocrine epithelial and myoepithelial components. Reports of myoepithelial tumors arising in AH have suggested a link between the 2. Read More

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Clinicopathologic Characterization of Hidradenoma on Acral Sites: A Diagnostic Pitfall With Digital Papillary Adenocarcinoma.

Am J Surg Pathol 2020 05;44(5):711-717

Department of Pathology and Laboratory Medicine.

Hidradenomas are benign sweat gland tumors that typically present as small nodules in adulthood. Their anatomic distribution is wide and rarely includes acral sites. In this setting, reliable separation from digital papillary adenocarcinoma is important, but notoriously difficult. Read More

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Lipomatous basal cell adenoma (Basal cell lipoadenoma) - Report of the first two cases.

Ann Diagn Pathol 2020 Feb 17;44:151444. Epub 2019 Dec 17.

Institute of Pathology, University Hospital Erlangen, Friedrich Alexander University (FAU), Erlangen, Germany.

We present, to the best of our knowledge, the first two cases (60 year old female and 71 year old male) of basal cell adenoma with significant adipocytic components and suggest the term "lipomatous basal cell adenoma" for these lesions. Both tumors presented as slow growing nodules in the parotid gland. The two cases represent different points on a histopathological spectrum with one case being extremely well differentiated with distinct spiradenoma-like histological features; distinct bilayering, duct formation with secretory material and very low proliferative activity and the other case displaying more primitive cytological features composed of a predominant uniform, (p63-positive; CK 7-negative) basaloid, abluminal cell type, high proliferative activity and only scattered true ducts composed of (CK7-positive, p63-negative) luminal cells. Read More

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February 2020

Spiradenoma With Adenoid Cystic Carcinoma-Like Features.

Am J Dermatopathol 2020 Jun;42(6):442-445

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX.

Spiradenoma is a benign cutaneous adnexal neoplasm that characteristically presents as a painful dermal nodule, often on the head or trunk. It has a distinct histologic phenotype and management involves surgical excision with low risk of recurrence. In comparison, adenoid cystic carcinoma (ACC) is a low-grade malignancy manifesting as an often painless subcutaneous mass with potential for local invasion, perineural extension, and high rates of recurrence after excision. Read More

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Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies.

Int J Surg Pathol 2020 Jun 9;28(4):427-435. Epub 2019 Dec 9.

Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Adenomyoepithelioma is an extremely rare primary cutaneous neoplasm. Although there is ample evidence on the existence of malignant adenomyoepithelioma in the breast, a malignant counterpart in the skin has not been documented. We report a primary cutaneous adenomyoepithelioma (pcAME) with malignant features arising from a spiradenoma in a 39-year-old female patient. Read More

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