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    [Malignant transformation of an eccrine spiradenoma].
    Ann Dermatol Venereol 2017 Mar 27;144(3):203-207. Epub 2016 Oct 27.
    Service de pathologie, centre hospitalier Lyon sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France.
    Introduction: Malignant eccrine spiradenoma is a rare and aggressive tumor, developed on the epithelium of eccrine sweat glands. Typically, it occurs after malignant transformation of benign eccrine spiradenoma, but sometimes it happens de novo.

    Observation: We report a case of malignant eccrine spiradenoma in a 62-year-old woman. Read More

    Cytopathologic features of an unusual case of multiple eccrine spiradenomas misdiagnosed as a malignant round cell tumor.
    J Cytol 2017 Jan-Mar;34(1):39-42
    Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India.
    A 28-year-old lady presented with multiple swellings in her left shoulder, associated with intermittent pain since last one and a half years. Radiologic imaging revealed multiple, well-defined, subcutaneous lesions in her left supraclavicular region. Fine needle aspiration cytology (FNAC) smears were initially reported as Ewing sarcoma, elsewhere. Read More

    MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
    J Cutan Pathol 2017 May 14;44(5):444-450. Epub 2017 Feb 14.
    Departments of Dermatology and Pathology, University of California, San Francisco, California.
    Background: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. Read More

    Nodular hidradenoma: Dermoscopic presentation.
    J Am Acad Dermatol 2017 Feb;76(2S1):S46-S48
    Department of Dermatology, University Hospital "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address:

    FDG PET/CT in Malignant Eccrine Spiradenoma.
    Clin Nucl Med 2017 Feb;42(2):125-126
    From the University of Texas Health Science Center at Houston, Houston, TX.
    Malignant eccrine spiradenoma is very rare skin appendageal cancer. We report a 64-year-old man who presented with a 6-month history of a rapidly growing mass in his groin. Physical examination revealed a 10-cm, ulcerated, fungating mass involving the entire right ilioinguinal region. Read More

    Understanding Inherited Cylindromas: Clinical Implications of Gene Discovery.
    Dermatol Clin 2017 Jan;35(1):61-71
    Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK; Department of Dermatology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. Electronic address:
    Cylindromas are cutaneous tumors first described in the medical literature over 150 years ago. They are now known to occur on an inherited basis as a result of mutations in the tumor-suppressor gene CYLD. The discovery of this gene has provided novel insights into this rare skin tumor syndrome. Read More

    Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature.
    Am J Dermatopathol 2016 Dec;38(12):910-914
    *Department of Dermatology, Toranomon Hospital, Tokyo, Japan; †Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Ishikawa, Japan; and ‡Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Tokyo, Japan.
    Aggressive digital papillary adenocarcinoma (ADPA) is a rare sweat gland neoplasm with a high recurrence rate and metastatic potential. In this study, the authors describe a case that originally appeared to benign spiradenoma, but took an ominous course eventually resulting in the diagnosis of ADPA. A 73-year-old woman developed a gradually growing nodule on the second toe of her left foot, which she had first noticed 4 years previously. Read More

    Glomus tumours of the hand: Review of literature.
    J Clin Orthop Trauma 2016 Oct-Dec;7(4):286-291. Epub 2016 Sep 1.
    All India Institute of Medical Sciences, New Delhi, India.
    Glomus tumours are rare benign vascular neoplasms commonly found in the hand particularly in subungual region. Though, its aetiology remains largely unknown, several hypotheses have been made to explain the etiopathogenesis and cause of pain. These tumours usually present as a bluish or pinkish red discolouration of the nail plate with classical triad of localised tenderness, severe pain, and cold sensitivity. Read More

    The role of DOG1 immunohistochemistry in dermatopathology.
    J Cutan Pathol 2016 Nov 5;43(11):974-983. Epub 2016 Sep 5.
    Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan.
    Background: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors.

    Methods: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues.

    Results: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum. Read More

    Spiradenoma causing longitudinal splitting of the nail.
    Clin Exp Dermatol 2016 Oct;41(7):754-6
    Department of Pathology, All India Institute Of Medical Sciences, Patna, India.
    Longitudinal splitting of the nails can occur as a result of any growth arising in the nail matrix. We present a case of a 50-year-old woman who presented with an 18-month history of longitudinal splitting of the nail on her right little finger, along with pain in the proximal nail fold region, which was extremely tender to touch. Magnetic resonance imaging revealed an intensely enhancing lesion, while colour Doppler imaging revealed hypervascularity within the mass. Read More

    Characteristics of Eccrine Tumors in a Tertiary Institution: A 5-Year Retrospective Study.
    Skinmed 2016 1;14(3):175-80. Epub 2016 Jun 1.
    Department of Pathology, Yong Loo Lin School of Medicine, National University Health System and National University of Singapore.
    Eccrine tumors are adnexal tumors with a varied clinical presentation and wide histological spectrum. This study aims to consolidate data on the clinical characteristics of eccrine tumors to help improve clinical acumen and management of such tumors. Histopathological records from January 2008 to December 2012 were retrieved. Read More

    Fine needle aspiration cytology of cylindroma of scalp: A case report.
    Diagn Cytopathol 2016 Dec 26;44(12):1082-1084. Epub 2016 Jul 26.
    Professor and Head, Department of Pathology, Institute of Postgraduate Medical Education and Research, Kolkata, India.
    Cylindromas are uncommon benign adnexal tumor. Multiple cylindromas are commonly genetically inherited and also known as "turban tumor." Cytology of dermal cylindroma is rarely discussed in previous literature. Read More

    Skin spiradenocarcinoma - case presentation.
    Rom J Morphol Embryol 2016 ;57(1):327-30
    Clinical Department, Faculty of Medicine and Pharmacy, "Lower Danube" University, Department of Surgery, "St. Apostle Andrew" Emergency Hospital, Galati, Romania;
    Malignant eccrine spiradenoma is an extremely rare skin tumor of sweat gland origin. The available literature data indicates that spiradenocarcinoma nearly uniformly arises from a benign preexisting spiradenoma. Etiology is unknown but previous trauma is believed being an implicated factor. Read More

    A rare case of eccrine spiradenoma-treatment and management.
    Eur J Plast Surg 2016;39:143-146. Epub 2015 Jun 17.
    Department of Plastic and Reconstructive Surgery, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka India.
    A young male patient presented with multiple swellings on his chest and the nape of his neck. Physical examination revealed multiple small papulonodular swellings measuring 0.5 × 0. Read More

    Brooke-Spiegler Syndrome and Phenotypic Variants: An Update.
    Head Neck Pathol 2016 Jun 14;10(2):125-30. Epub 2016 Mar 14.
    Department of Pathology, Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic.
    Brooke-Spiegler syndrome (BSS) is an inherited autosomal dominant disease characterized by the development of multiple adnexal cutaneous neoplasms most commonly spiradenoma, cylindroma, spiradenocylindroma, and trichoepithelioma. Multiple familial trichoepithelioma (MFT) is a phenotypic variant of the disease characterized by the development of numerous trichoepitheliomas (cribriform trichoblastoma) only. Malignant tumors arise in association with preexisting benign cutaneous neoplasms in about 5-10% of the patients . Read More

    Zosteriform spiradenoma with spiradenocarcinoma: A rare entity.
    Indian Dermatol Online J 2015 Dec;6(Suppl 1):S30-2
    Department of DVL, Seth GS Hospital, Mumbai, India.
    Eccrine spiradenoma (ES) is an uncommon well-differentiated benign tumor originating from the sweat glands. It usually occurs as a single lesion in adults. Multiple ES in a linear or zosteriform distribution are rare. Read More

    Distinctive immunostaining of claudin-4 in spiradenomas.
    Ann Diagn Pathol 2016 Feb 28;20:44-7. Epub 2015 Oct 28.
    Department of Pathology, Gülhane Military Medical Academy and School of Medicine, Ankara, Turkey. Electronic address:
    The intercellular bridges are essential structures in maintaining the histologic organization of the epithelium, while providing a very efficient way to exchange molecules between cells and transduction of the cell-to-cell and matrix-to-cell signals. Derangement in those important structures' physical integrity and/or function, which can be assessed by the presence or absence of several intercellular bridge proteins including claudin-4, E-cadherin, and β-catenin, was found to be related to several phenomena in the path to the neoplastic transformation. However, these proteins have not been studied in the wide variety of the skin neoplasms, in detail. Read More

    Sonographic and sonoelastographic findings of a rarely seen soft tissue tumor: eccrine spiradenoma.
    J Med Ultrason (2001) 2015 Oct 23;42(4):587-90. Epub 2015 May 23.
    Department of Radiology, Ankara Atatürk Education and Research Hospital, Eskisehir Yolu 8. Km, no:3 Bilkent, 06800, Ankara, Turkey.
    Eccrine spiradenoma is a rare benign tumor originating from sweat glands. Its sonographic characteristics have been described in only a few reports, and there is no such report available that describes sonoelastographic findings of this tumor. In this case report, we aimed to define the sonographic and sonoelastographic findings of a benign eccrine spiradenoma. Read More

    Brooke-Spiegler Syndrome - an underrecognized cause of multiple familial scalp tumors: report of a new germline mutation.
    J Dermatol Case Rep 2015 Sep 30;9(3):67-70. Epub 2015 Sep 30.
    Dermatology Department of Centro Hospitalar e Universitário de Coimbra, Portugal.
    Background: Brooke-Spiegler syndrome (BSS) is probably an underdiagnosed genodermatosis that predisposes for the development of cylindromas, spiradenomas and trichoepitheliomas mainly of the head and neck. Wide phenotypic variability regarding the number and type of lesions can be observed within a family. Mutations of the CYLD gene are identified in the vast majority of cases and play a key role in BSS pathogenesis. Read More

    Locally Advanced Spiroadenocarcinoma in the Regional Axilla of a Breast Cancer Patient: Hallmarks of Definitive Diagnosis and Management.
    Rare Tumors 2015 Sep 7;7(3):5912. Epub 2015 Sep 7.
    Division of Surgical Oncology, UC Davis School of Medicine , Sacramento, CA, USA.
    Eccrine spiroadenocarcinoma is an extremely rare malignant eccrine gland tumor which may masquerade as other more common malignancies such as poorly differentiated squamous carcinoma or metastatic breast cancer. We report a case of an ulcerated axillary skin lesion with bulky adenopathy in a 77 year-old female with a prior history of ipsilateral triple negative breast carcinoma. The clear transition of benign spiradenoma to malignant carcinoma was essential to establishing a definitive diagnosis and treatment plan. Read More

    Malignant eccrine breast spiradenoma. A case report and literature review.
    Int J Surg Case Rep 2015 18;15:81-4. Epub 2015 Aug 18.
    University GeneralHospital of Valencia, Av. De les Tres Creus, 2, 46014 València, Spain.
    Introduction: Eccrine spiradenomas are rare adnexal tumours of the skin that originate in the sweat glands. There are only three cases, including ours, diagnosed as malignant transformation in the breast.

    Presentation Of Case: We present a case of an asymptomatic 48 year old woman in whom the lesion was detected on the basis of breast cancer prevention programme. Read More

    Multiple Segmental Eccrine Spiradenoma with a Zosteriform Pattern: A Case Report and Literature Review.
    Ann Dermatol 2015 Aug 29;27(4):435-8. Epub 2015 Jul 29.
    Southern Medical University, Nanjing, China. ; Department of Dermatology, Jinling Hospital, Nanjing University of Medicine, Nanjing, China.
    Eccrine spiradenoma usually occurs as solitary tender nodules. However, it rarely occurs as multifocal localized tumors or has zosteriform distribution. We report the case of a 32-year-old woman with a 20-year history of itchy lesions on the left side of the back and forearm with a zosteriform distribution. Read More

    Low-grade cylindromatous adnexal carcinoma with unusual histopathological features: report of a case with comparative immunohistochemical study and meta-analysis of the literature.
    J Cutan Pathol 2015 Aug 13. Epub 2015 Aug 13.
    Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
    We present an extremely rare case of low-grade cylindromatous adnexal carcinoma (CAC) on the right chest wall of a 77-year-old man. Histopathologically, the neoplasm was initially diagnosed as a cylindroma that developed over the course of 13 years. A diagnosis of low-grade CAC was rendered after the documentation of a local recurrence and histopathology of the recurrent tumor. Read More

    Perineural growth of benign cutaneous sweat gland tumors: a hitherto unrecognized phenomenon unassociated with malignancy.
    J Cutan Pathol 2015 Nov 3;42(11):878-83. Epub 2015 Sep 3.
    Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
    Background: Cutaneous intraneural reactive epithelial proliferations mimicking malignancy include epithelial sheath neuroma, re-excision perineural invasion and reactive neuroepithelial aggregates. Nevertheless, intraneural growth of benign sweat gland tumors has not been reported before.

    Aims: To report a predominantly intraneural proliferation of morphologically bland sweat gland tumors, describe their clinicopathological features and correlate them with survival. Read More

    Eccrine Spiradenoma Arising from the Breast Skin.
    Case Rep Pathol 2015 7;2015:615158. Epub 2015 Jul 7.
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
    Eccrine spiradenomas are uncommon, benign lesions, which are thought to originate from the eccrine sweat glands. They are common in young adults and are without a sex predilection. Here we report a case of eccrine spiradenoma of the breast skin in a 39-year-old woman who presented with a breast nodule for 10 years. Read More

    Malignant eccrine spiradenoma of the external ear.
    Kulak Burun Bogaz Ihtis Derg 2015 ;25(4):245-8
    Department of Otolaryngology, Medical Faculty of Abant İzzet Baysal University, 14280 Gölköy, Bolu, Turkey.
    Eccrine spiradenoma is a benign tumor of sweat gland origin. Malignant eccrine spiradenoma is a rare neoplasm which almost always arises from a pre-existing spiradenoma lesion. In this article, we present a patient with malignant eccrine spiradenoma of the auricula with a prior diagnosis as benign eccrine spiradenoma. Read More

    Malignant Eccrine Spiradenoma of the Face.
    J Craniofac Surg 2015 Jul;26(5):1711-2
    *Division of Plastic Surgery †Division of Dermatopathology, Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
    Malignant eccrine spiradenoma, or spiradenocarcinoma, is an exceedingly rare sweat-gland tumor, with only 102 reported cases. Low-grade carcinomas are especially rare with only a few cases reported. Because of the limited number of case reports, the biologic behavior of low-grade malignant eccrine spiradenoma is poorly understood and no evidence-based therapeutic approach is established. Read More

    A serpentine inside eccrine spiradenoma: a new trichoscopic sign.
    Int J Trichology 2015 Jan-Mar;7(1):38-40
    Department of Dermatology, Nijalingappa Medical College, Bagalkot, Karnataka, India.
    Trichoscopy being an in vivo technique aids in magnification of cutaneous structures with appropriate pattern and color. A female presented with erythematous tumor on scalp. Histopathology showed features of eccrine spiradenoma. Read More

    Morphologically low-grade spiradenocarcinoma: a clinicopathologic study of 19 cases with emphasis on outcome and MYB expression.
    Mod Pathol 2015 Jul 10;28(7):944-53. Epub 2015 Apr 10.
    Department of Pathology, Western General Hospital and The University of Edinburgh, Edinburgh, UK.
    Spiradenocarcinoma is a rare skin adnexal neoplasm with potential for aggressive behavior, classified histologically into low- and high-grade tumors. Morphologically, low-grade tumors are thought to behave more favorably. Limited information is available, however, with only 18 published cases. Read More

    Spiradenocarcinoma in Preexisting Spiradenoma With a Large In Situ Adenocarcinoma Component.
    Am J Dermatopathol 2015 Oct;37(10):e122-5
    Sapporo Dermatopathology Institute, Sapporo, Japan.
    Spiradenocarcinoma is a very rare malignant tumor. In situ adenocarcinoma has recently been observed and defined by the preservation of a peripheral myoepithelial cell layer. The pathway for this phenomenon has been hypothesized to involve a sequence of adenomatous changes followed by atypical adenomatous changes, adenocarcinoma in situ, and invasive adenocarcinoma. Read More

    Inexplicable Co- Existence of Eccrine Spiradenoma and Lichen Planus in an old Case of Basal Cell Carcinoma.
    J Clin Diagn Res 2015 Jan 1;9(1):ED01-2. Epub 2015 Jan 1.
    Post Graduate, Department of Pathology, Affiliated to Rajiv Gandhi University of Health Sciences, Adichunchanagiri Institute of Medical Sciences , B. G. Nagar, Mandya, Karnataka, India .
    Eccrine spiradenoma is a rare benign adnexal tumour usually seen in the head, neck or upper trunk in young adults. It is rare in the lower extremities and in the elderly. Co- existence of eccrine spiradenoma with other lesions like cylindroma, trichoepithelioma, hidradenoma and chondroid syringoma has been documented in literature. Read More

    CYLD GeneticTesting for Brooke-Spiegler Syndrome, Familial Cylindromatosis and Multiple Familial Trichoepitheliomas.
    PLoS Curr 2015 Feb 19;7. Epub 2015 Feb 19.
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
    The clinical presentation of multiple, rare, skin appendage tumours called cylindromas has been attributed to germline mutations in the tumour suppressor gene CYLD (OMIM 605018). Brooke-Spiegler Syndrome (BSS), familial cylindromatosis (FC) and multiple familial trichoepitheliomas (MFT) (OMIM #605041, #132700, #601606 respectively) differ due to the types of other skin appendage tumour seen together with cylindroma, such as spiradenoma and trichoepithelioma. Previously thought to be separate entities, they are now viewed as allelic variants with overlapping phenotypes, supported by mutation analysis of CYLD . Read More

    Zosteriform configuration of multiple eccrine spiradenomas of the scalp.
    Ann Chir Plast Esthet 2016 Feb 30;61(1):65-8. Epub 2014 Dec 30.
    Department of Maxillofacial, Plastic Reconstructive and Aesthetic Surgery, Nancy University Hospital, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54000 Nancy, France.
    Background: Eccrine spiradenoma (ES) is a benign adnexal tumor predominantly located in the head and neck regions. Multiple neoplasms located on the scalp have been reported but never with a zosteriform configuration on the first trigeminal area.

    Case Report: We describe an original case report of a 75-year-old Caucasian man presenting multiple subcutaneous blue and purple nodules disseminated on the first left trigeminal dermatome. Read More

    Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers.
    J Cutan Pathol 2015 Feb 24;42(2):90-101. Epub 2014 Nov 24.
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
    Background: Spiradenoma and cylindroma have historically been described as sweat gland tumors and have often been considered to be of eccrine lineage. However, (a) associations with trichoepitheliomas in Brooke-Spiegler syndrome or with trichoepitheliomas and milia in Rasmussen syndrome, (b) neoplastic combinations with hair follicle tumors in solitary cases, and (c) anatomical considerations support a folliculosebaceous-apocrine lineage. Follicular stem cell markers may allow for further characterization of these neoplasms. Read More

    Fine needle aspiration cytology of eccrine spiradenoma of back: report of a rare case.
    J Lab Physicians 2014 Jul;6(2):130-2
    Department of Pathology, Bankura Sammilani Medical College, Bankura, West Bengal, India.
    Eccrine spiradenoma is an uncommon benign adnexal tumor. Cytological features of eccrine spiradenoma have been described very rarely in English literature. In the present case, we are describing a case of eccrine spiradenoma of back, which was diagnosed by fine-needle aspiration cytology and subsequently confirmed by histopathology. Read More

    Cystic eccrine spiradenoma of the finger mimicking a ganglion.
    Plast Reconstr Surg Glob Open 2014 Jan 7;2(1):e95. Epub 2014 Feb 7.
    Department of Orthopaedics, Bundaberg Base Hospital, Bundaberg, Queensland, Australia.
    Summary: We report a rare case of cystic eccrine spiradenoma in the finger. A 46-year-old man presented with a cystic mass in his left index finger. Clinical assessment along with the investigation pointed toward a diagnosis of a ganglion. Read More

    Eccrine spiradenoma in knee.
    Indian J Dermatol 2014 Sep;59(5):513-5
    Department of Pathology, Burdwan Medical College, Burdwan, India.
    Eccrine spiradenoma is an uncommon benign adnexal tumor of the eccrine sweat glands. Although it can occur at any age, it is most common in young adults without any sex predilection. Malignant transformation is rare, presenting as rapid increase in size of a long-standing lesion. Read More

    Differential diagnosis of eccrine spiradenoma: A case report.
    Exp Ther Med 2014 Oct 14;8(4):1097-1101. Epub 2014 Aug 14.
    Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.
    Eccrine spiradenoma (ES) is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. A 44-year-old male with a blue-colored, nodular tumor on the left knee, present for 10 years, was submitted for diagnosis. Dermatological examination was undertaken, followed by surgical excision of the subcutaneous lesion and histopathological examination of the tissue. Read More

    [Cutaneous adnexal and salivary gland tumours. Similarities and differences].
    Pathologe 2014 Sep;35(5):476-86
    Labor für Dermatohistologie und Oralpathologie, Bayerstr. 69, 80335, München, Deutschland,
    Despite major discrepancies in basic microscopic anatomy, remarkable similarities are manifest within the wide spectrum of cutaneous adnexal and salivary gland tumors. In this study salivary gland and adnexal tumors were identified and investigated with respect to similarities in histology, terminology and pathogenesis. Histological similarities of certain types of salivary gland tumors relate to eccrine, apocrine and rarely sebaceous (but not trichofollicular) types of adnexal tumors. Read More

    Case of recurrence of spiradenoma in palpebral conjunctiva.
    BMC Ophthalmol 2014 Jun 27;14:85. Epub 2014 Jun 27.
    Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi 501-1194, Japan.
    Background: To report a rare case of a recurrence of spiradenoma that developed in the upper eyelid.

    Case Presentation: A 49-year-old woman who had a second recurrence of a tumor in the right palpebral conjunctiva underwent local resection of the lesion with adjunctive cryotherapy to the surgical site. The tumor consisted of smooth, round to oval nodular lesions approximately 1-3 mm in size with enlarged blood vessels. Read More

    A malignant eccrine spiradenoma of the scalp.
    BMJ Case Rep 2014 May 19;2014. Epub 2014 May 19.
    St Andrew's Centre for Plastic Surgery and Burns, Mid Essex Hospital Services NHS Trust, Essex, UK.
    Malignant eccrine spiradenoma (MES) is an extremely rare but aggressive tumour, resulting in high mortality. We report the first case in the UK of metastatic MES on the scalp of a 37-year-old man who initially presented with a raised nodular mass which had grown rapidly over a few months. Excision biopsy of the lesion was performed and histology confirmed MES with evidence of cytological atypia and necrosis. Read More

    [CO2 laser treatment of skin cylindromas in Brooke-Spiegler syndrome].
    Ann Dermatol Venereol 2014 May 12;141(5):346-53. Epub 2014 Apr 12.
    Service de dermatologie, CHU de Caen, avenue Clemenceau, 14000 Caen, France.
    Background: Multiple skin cylindromas are of autosomal dominant transmission and may be associated with spiradenoma and trichoepithelioma. This condition is known as Brooke-Spiegler syndrome. The aim of this study is to compare surgical and laser treatment for these lesions. Read More

    Tumours of the skin adnexa: a case series with focus on multiple segmental forms.
    Pathologica 2013 Dec;105(6):337-41
    Objective: Skin adnexal tumours (SAT) as a whole are rare tumours, and most of our current knowledge on SAT is from single case reports or small series focused on single histotypes. The purpose of this paper is to review a series of benign and malignant SAT diagnosed in a 20-year period.

    Methods: All consecutive cases of SAT diagnosed between January 1992 and Dicember 2011 were retrieved. Read More

    Immunohistochemical characterization of non-epithelial cells in spiradenoma.
    J Dermatol 2013 Nov 23;40(11):896-900. Epub 2013 Sep 23.
    Department of Dermatology, Showa University School of Medicine, Tokyo.
    Spiradenoma is unique with respect to the presence of a large number of non-epithelial cells, including S100 protein(+) cells, most of which are presumably Langerhans cells, in the parenchyma as shown in the published work. However, the characterization of these non-epithelial cells to date is insufficient. Immunohistochemistry of CD1a, CD3, CD4, CD8, CD56, CD68, intercellular adhesion molecule-1 (ICAM-1), and HLA-DR, as well as double-immunofluorescence labeling of S100 protein/CD1a and CD1a/CD3, was performed using paraffin-embedded specimens from five cases of spiradenoma retrospectively. Read More

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