872 results match your criteria Spiradenoma


Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings.

Int J Surg Pathol 2020 May 4:1066896920916792. Epub 2020 May 4.

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

. The expression of terminal deoxynucleotidyl transferase (TdT) in myoepithelial cells (MECs) within the breast was recently incidentally observed in our routine practice. This study aimed to elucidate the expression of TdT in MECs. Read More

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http://dx.doi.org/10.1177/1066896920916792DOI Listing

Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions.

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

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http://dx.doi.org/10.7759/cureus.6955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067514PMC
February 2020

Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV.

Diagn Pathol 2020 Mar 14;15(1):24. Epub 2020 Mar 14.

Pathology Department, Erasme University Hospital, Université Libre de Bruxelles, CP 610, Route de Lennik, 808, 1070, Brussels, Belgium.

Background: Malignant eccrine spiradenoma is one of the rarest sweat-gland tumors. Here, we describe a rare case of low grade malignant eccrine spiradenoma located at the vulva.

Case Presentation: The vulvar lesion was described as a mass measured 3. Read More

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http://dx.doi.org/10.1186/s13000-020-00945-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071686PMC

Lipomatous basal cell adenoma (Basal cell lipoadenoma) - Report of the first two cases.

Ann Diagn Pathol 2020 Feb 17;44:151444. Epub 2019 Dec 17.

Institute of Pathology, University Hospital Erlangen, Friedrich Alexander University (FAU), Erlangen, Germany.

We present, to the best of our knowledge, the first two cases (60 year old female and 71 year old male) of basal cell adenoma with significant adipocytic components and suggest the term "lipomatous basal cell adenoma" for these lesions. Both tumors presented as slow growing nodules in the parotid gland. The two cases represent different points on a histopathological spectrum with one case being extremely well differentiated with distinct spiradenoma-like histological features; distinct bilayering, duct formation with secretory material and very low proliferative activity and the other case displaying more primitive cytological features composed of a predominant uniform, (p63-positive; CK 7-negative) basaloid, abluminal cell type, high proliferative activity and only scattered true ducts composed of (CK7-positive, p63-negative) luminal cells. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.151444DOI Listing
February 2020

Spiradenoma With Adenoid Cystic Carcinoma-Like Features.

Am J Dermatopathol 2020 Jun;42(6):442-445

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX.

Spiradenoma is a benign cutaneous adnexal neoplasm that characteristically presents as a painful dermal nodule, often on the head or trunk. It has a distinct histologic phenotype and management involves surgical excision with low risk of recurrence. In comparison, adenoid cystic carcinoma (ACC) is a low-grade malignancy manifesting as an often painless subcutaneous mass with potential for local invasion, perineural extension, and high rates of recurrence after excision. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001594DOI Listing

Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies.

Int J Surg Pathol 2020 Jun 9;28(4):427-435. Epub 2019 Dec 9.

Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Adenomyoepithelioma is an extremely rare primary cutaneous neoplasm. Although there is ample evidence on the existence of malignant adenomyoepithelioma in the breast, a malignant counterpart in the skin has not been documented. We report a primary cutaneous adenomyoepithelioma (pcAME) with malignant features arising from a spiradenoma in a 39-year-old female patient. Read More

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http://dx.doi.org/10.1177/1066896919888579DOI Listing

Giant vascular eccrine spiradenoma presenting as a thrombosed varix.

J Vasc Surg Cases Innov Tech 2019 Dec 26;5(4):583-585. Epub 2019 Nov 26.

Department of Vascular Surgery, Mater Adult Hospital, South Brisbane, Queensland, Australia.

Eccrine spiradenoma is a benign adnexal tumor of the sweat gland. Giant vascular eccrine spiradenoma is a rare variant of eccrine spiradenoma, characterized by its large size and florid vascularity. Its rarity and clinical appearance give rise to typical misdiagnosis as angiomatous lesions. Read More

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http://dx.doi.org/10.1016/j.jvscit.2019.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881652PMC
December 2019

Solid-Cystic Hidradenoma: A Dorsal Foot Presentation.

J Am Podiatr Med Assoc 2019 Sep;109(5):389-392

Solid-cystic hidradenoma is a benign cutaneous tumor with eccrine sweat gland origins that is most commonly found in the head, neck, trunk, and upper extremity regions of patients in the middle to older age groups. These lesions are generally asymptomatic, slow-growing, solitary, and nonulcerative in presentation. Degenerative malignant transformation of this tumor is very rare. Read More

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http://dx.doi.org/10.7547/17-136DOI Listing
September 2019
1 Read

Skin swelling in the axillary fold in an elderly man.

Cytopathology 2020 Jan 11;31(1):73-74. Epub 2019 Sep 11.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/cyt.12760DOI Listing
January 2020
4 Reads

Snow Falling Sign in a Long-Standing Tumor.

Actas Dermosifiliogr 2019 Nov 27;110(9):765-766. Epub 2019 Jun 27.

Servicio de Dermatología, Fundación Jiménez Díaz, Madrid, España.

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http://dx.doi.org/10.1016/j.ad.2018.05.020DOI Listing
November 2019
2 Reads

Magnifying glass on spiradenoma and cylindroma histogenesis and tumorigenesis using systematic transcriptome analysis.

Ann Diagn Pathol 2019 Aug 5;41:14-23. Epub 2019 May 5.

Department of Pathology, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA; Department of Head and Neck Surgery, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. Electronic address:

Spiradenoma and cylindroma are related sweat gland tumors. To delineate their histogenesis, gene profiles, and their potential drivers, we performed a whole-transcriptome sequencing analysis of fourteen samples of spiradenoma/cylindroma in comparison to normal samples. A total of 12 spiradenomas, 5 cylindromas, 3 hybrid spiradenomas/cylindromas and 2 adnexal carcinomas were included in this study. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.04.015DOI Listing
August 2019
14 Reads

An Unusual Nodule on the Auricle: Eccrine Spiradenoma.

Ear Nose Throat J 2019 Oct-Nov;98(9):545-546. Epub 2019 May 23.

School of Medicine, University of Belgrade, Belgrade, Serbia.

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http://dx.doi.org/10.1177/0145561319850815DOI Listing
April 2020
7 Reads

ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

Nat Commun 2019 05 17;10(1):2213. Epub 2019 May 17.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, UK.

Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation and potential for malignant transformation and aggressive behaviour. We present the genomic analysis of 75 samples from 57 representative patients including 15 cylindromas, 17 spiradenomas, 2 cylindroma-spiradenoma hybrid tumors, and 24 low- and high-grade spiradenocarcinoma cases, together with morphologically benign precursor regions of these cancers. We reveal somatic or germline alterations of the CYLD gene in 15/15 cylindromas and 5/17 spiradenomas, yet only 2/24 spiradenocarcinomas. Read More

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http://dx.doi.org/10.1038/s41467-019-09979-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525246PMC
May 2019
13 Reads

Diverse presentations of cutaneous mosaicism occur in CYLD cutaneous syndrome and may result in parent-to-child transmission.

J Am Acad Dermatol 2019 Dec 11;81(6):1300-1307. Epub 2019 May 11.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom. Electronic address:

Background: Clusters of rare cylindroma or spiradenoma tumors are a recurrent clinical presentation, yet conventional genetic testing results in individuals with these tumors are frequently normal.

Objective: To determine if genetic mosaicism accounts for such cases.

Methods: A study of 6 cases from a series of 55 patients who met criteria for diagnostic gene testing for pathogenic CYLD variants over a 5-year period (2012-2017) was performed. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878220PMC
December 2019
4 Reads

Incisional biopsy critical in obtaining definitive diagnosis in a clinically challenging case.

Dermatol Online J 2019 Apr 15;25(4). Epub 2019 Apr 15.

Department of Dermatology, Baylor College of Medicine, Houston, Texas Laboratory and Pathology Services, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.

Tissue-sparing biopsy techniques are frequently used in clinical practice but can result in misdiagnosis of large, clinically challenging lesions. We present a case of a 70-year-old man with hidradenocarcinoma of the left chin, a diagnosis that was delayed owing to repeated superficial biopsies that were negative for disease. Diagnosis was ultimately obtained via an incisional biopsy. Read More

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April 2019
2 Reads

Trichoblastic carcinoma arising in trichoepithelioma in Brooke-Spiegler syndrome.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):313-318

Department of Pathology, Government Medical College, Kottayam, Kerala, India.

Brooke-Spiegler syndrome (BSS) is a rare autosomal dominant disease characterized by the development of multiple cutaneous adnexal neoplasms namely cylindroma, trichoepithelioma and spiradenoma. The neoplasms associated with this syndrome are generally benign, but rarely they may undergo malignant transformation. A 63-year-old male presented with an ulcerated nodular lesion over glabella and multiple asymptomatic nodular lesions over face, scalp, chest and limbs. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_639_17DOI Listing
August 2019
12 Reads

Immunohistochemical Study of Non-Epithelial Cells in Spiradenoma.

J Nippon Med Sch 2019 ;86(1):15-21

Department of Dermatology, Nippon Medical School.

Background: Intratumoral lymphocytes are a defining feature of spiradenoma; however, there have only been a few reports on the phenotypic features of non-epithelial cells. Spiradenomas also contain numerous cells positive for S-100 protein and the nature of these cells is still controversial.

Methods: We performed a clinicopathological and immunohistochemical study of ten cases of spiradenoma. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2019_86-3DOI Listing
April 2019
6 Reads

Eccrine spiradenoma of the nipple: Case report, differential diagnosis and literature review.

Histol Histopathol 2019 Aug 26;34(8):909-915. Epub 2019 Feb 26.

Department of Medical Sciences, University of Turin, Turin, Italy.

Eccrine spiradenoma is a rare lesion originating from eccrine sweat glands, with only few cases reported in breast tissue: we here describe for the first time, an eccrine spiradenoma arising in the nipple. An 84 year-old woman with a lesion enlarging her right nipple, showing ulcerations and eczema-like changes of the covering skin, was admitted to our hospital. Surgical excision of the central quadrant with nipple-areola complex was performed, followed by histopathological evaluation which revealed an adenoma with predominantly basaloid epithelial cells. Read More

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http://dx.doi.org/10.14670/HH-18-094DOI Listing
August 2019
22 Reads

"Hidradenoma of the breast: Magnetic resonance (MR) imaging and ultrasonography (US) findings of this rare mass".

Breast J 2019 03 14;25(2):314-315. Epub 2019 Feb 14.

Department of Radiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey.

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http://doi.wiley.com/10.1111/tbj.13216
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http://dx.doi.org/10.1111/tbj.13216DOI Listing
March 2019
25 Reads

Case Report and Literature Review of Nodular Hiradenoma, a Rare Adnexal Tumor That Mimics Breast Carcinoma, in a 20-Year-Old Woman.

Lab Med 2019 Jul;50(3):320-325

Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center McGovern Medical School, Houston, Texas.

Nodular hidradenoma is an uncommon cutaneous adnexal tumor arising from sweat glands. In the skin, it usually presents as a solitary dermal nodule; excision is curative in most cases. In rare instances, it may present as a breast mass and can mimic breast carcinoma clinically and radiologically, causing diagnostic dilemmas for the treating physician and pathologist. Read More

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http://dx.doi.org/10.1093/labmed/lmy084DOI Listing
July 2019
5 Reads

Histological findings and pathologic diagnosis of spiradenocarcinoma: A case series and review of the literature.

J Cutan Pathol 2019 Apr 31;46(4):243-250. Epub 2019 Jan 31.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Atypical spiradenoma and spiradenocarcinoma present a diagnostic challenge. We aim to assess the significance of certain histologic features, which may facilitate diagnosis of these tumors.

Methods: A natural language search for cases of "atypical spiradenoma" and "spiradenocarcinoma" diagnosed between 2009 and 2018 was performed. Read More

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http://doi.wiley.com/10.1111/cup.13408
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http://dx.doi.org/10.1111/cup.13408DOI Listing
April 2019
17 Reads

Malignant transformation of a spiradenoma with blaschkoïd pattern.

Clin Case Rep 2018 Nov 17;6(11):2086-2088. Epub 2018 Sep 17.

Department of Dermatology and Venereology Ibn Sina University Hospital Rabat Morocco.

Eccrine spiradenoma is a benign and rare adnexal tumor originating from cutaneous eccrine sweat glands. It usually presents as a solitary lesion. It can have different presentations, including a blaschkoid arrangement which is rare. Read More

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http://dx.doi.org/10.1002/ccr3.1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230602PMC
November 2018
16 Reads

A rare case of Brooke-Spiegler syndrome: integrated surgical treatment of multiple giant eccrine spiradenomas of the head and neck in a young girl.

Int J Surg Case Rep 2018 12;51:277-281. Epub 2018 Sep 12.

Department of Plastic and Reconstructive Surgery, University Hospital of Foggia, Foggia, Italy.

Introduction: The authors present a "four-step" integrated surgical protocol to treat a rare case of multiple giant eccrine spiradenoma (ES) of the head and neck in a young patient.

Presentation Of Case: An 18-year-old female patient presented with multiple swellings in the head and neck regions. The patient had a severe psychological trauma with a negative impact on her social life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183032
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http://dx.doi.org/10.1016/j.ijscr.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146587PMC
September 2018
26 Reads

Dermoscopy of Adnexal Tumors.

Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.

Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.

Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.007DOI Listing
October 2018
67 Reads

Brooke-Spiegler Syndrome.

Eplasty 2018 23;18:ic14. Epub 2018 Jul 23.

Department of Plastic Surgery, Morsani College of Medicine, Tampa, Fla.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062842PMC
July 2018
19 Reads

Eccrine spiradenoma: A rare adnexal tumor.

Indian J Cancer 2017 Oct-Dec;54(4):695-696

Department of Pathology, 166 Military Hospital, Jammu, Jammu and Kashmir, India.

Eccrine spiradenoma is one of the rare adnexal tumors with eccrine differentiation; however, it is considered to have apocrine differentiation. Around 50 cases of eccrine spiradenoma have been reported in the literature. Due to vascularity and painful symptoms, it is often confused with the painful lesions of skin such as glomus tumor and angioleiomyoma. Read More

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http://dx.doi.org/10.4103/ijc.IJC_301_17DOI Listing
October 2018
13 Reads

p63 and smooth muscle actin expression in low-grade spiradenocarcinomas in a case of CYLD cutaneous syndrome.

J Cutan Pathol 2018 Oct 19;45(10):760-763. Epub 2018 Jul 19.

Department of Pathology, Southern General Hospital, Glasgow, UK.

Low-grade spiradenocarcinoma is a rare skin tumor, with fewer than six reported cases, arising in the context of CYLD cutaneous syndrome (CCS; syn: Brooke-Spiegler syndrome [BSS]). We report two independent cases of spiradenocarcinoma arising in a 50-year-old man with CCS. The tumors grew rapidly, prompting clinical excision. Read More

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http://dx.doi.org/10.1111/cup.13311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175182PMC
October 2018
14 Reads

Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11154

Department of Radiology, Konkuk University School of Medicine, Seoul.

Rationale: Poroid hidradenoma (PH) is a rare variant of benign sweat gland neoplasm without connection to the epidermis. This tumor presents clinically as a solitary lesion with a cystic component located in the subcutaneous layer abutting the skin. On ultrasound, it appears as a circumscribed complex cystic and solid mass abutting the dermis. Read More

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http://dx.doi.org/10.1097/MD.0000000000011154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023949PMC
June 2018
9 Reads

A Nodular Hidradenoma of Atypical Location in Pregnancy.

Acta Derm Venereol 2018 Oct;98(9):908-909

University of Texas McGovern Medical School at Houston, , 77030 Houston, TX, USA.

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http://dx.doi.org/10.2340/00015555-2983DOI Listing
October 2018
14 Reads
3.025 Impact Factor

[Hidradenocarcinoma of the Scrotum with Lymph Node Metastasis].

Acta Med Port 2018 Mar 29;31(3):176-179. Epub 2018 Mar 29.

Unidade Funcional Medicina 1.4. Hospital de São José. Centro Hospitalar Lisboa Central. Lisboa, Portugal.

Hidradenocarcinoma is a rare neoplasm of the eccrine cells of the sweat glands, usually asymptomatic with slow growing and higher incidence between 50 and 80 years, occurring in both sexes and preferentially located in the palmar, plantar, frontal, axillary and nuchal regions. It has an aggressive behavior, with high rate of local recurrence and distance metastasis, associated with a poor prognosis. We present a case of hidradenocarcinoma of the scrotum manifested by lymph node metastasis through an exercise of clinical and histological differential diagnosis of an inguinal adenopathy in a young adult. Read More

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http://dx.doi.org/10.20344/amp.9017DOI Listing
March 2018
7 Reads

Erythematous Pedunculated Papule on the Knee.

Actas Dermosifiliogr 2018 Jul - Aug;109(6):543-544. Epub 2018 Mar 26.

Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Albacete, Albacete, España.

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http://dx.doi.org/10.1016/j.ad.2017.01.023DOI Listing
June 2019
1 Read

Multiple eccrine spiradenomas in a zosteriform pattern.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, Texas,.

Eccrine spiradenoma (ES) typically presents as a solitary tender lesion. Multiple ES is a rare variant of ES and can present in a segmental, linear, blaschkoid, or zosteriform pattern. The etiology of multiple ES is unknown, but several theories have been suggested including a multipotent stem cell origin. Read More

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August 2017
45 Reads

Allergic contact dermatitis to methylisothiazolinone in hair care products: report of a case.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Baylor College of Medicine, Houston, Texas.

Eccrine spiradenoma (ES) typically presents as a solitary tender lesion. Multiple ES is a rare variant of ES and can present in a segmental, linear, blaschkoid, or zosteriform pattern. The etiology of multiple ES is unknown, but several theories have been suggested including a multipotent stem cell origin. Read More

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August 2017
12 Reads

Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells.

Histopathology 2018 Jun 25;72(7):1199-1208. Epub 2018 Mar 25.

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Aims: A number of homeobox transcriptional factors are utilised as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is expressed specifically in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms.

Methods And Results: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be expressed specifically in the skin. Read More

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http://dx.doi.org/10.1111/his.13486DOI Listing
June 2018
27 Reads

Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging.

J Ultrasound Med 2018 Aug 1;37(8):1993-2001. Epub 2018 Feb 1.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Objectives: The purpose of this study was to evaluate the imaging features of clear cell hidradenoma on ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI).

Methods: The radiologic and pathologic databases at 2 medical institutions were searched retrospectively from 2004 to 2016 to identify patients with a diagnosis of clear cell hidradenoma. Ultrasonographic, CT, and MRI features were described, and pathologic specimens were reviewed. Read More

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http://dx.doi.org/10.1002/jum.14552DOI Listing
August 2018
9 Reads

Sonographic appearance of an eccrine spiradenoma: A case report.

J Clin Ultrasound 2018 Sep 22;46(7):494-496. Epub 2017 Dec 22.

Department of Radiology, Myongji Hospital, Seonam University College of Medicine, 55, Hwasu-ro 14 beon-gil, Deogyang-gu, Goyang-si, Gyeonggi-do, Republic of Korea.

Eccrine spiradenoma is a rare, benign, adnexal skin tumor of the sweat gland, which may manifest in any part of the body. It is typically located in the dermal or the subcutaneous fat layer. Eccrine spiradenomas rarely progress to malignant transformation and only a few cases of malignant transformation have been reported. Read More

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http://dx.doi.org/10.1002/jcu.22572DOI Listing
September 2018
24 Reads

Ultrasound Diagnosis of Nodular Hidradenoma.

Actas Dermosifiliogr 2018 Jun 1;109(5):453-455. Epub 2017 Dec 1.

Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, España.

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http://dx.doi.org/10.1016/j.ad.2017.06.017DOI Listing
June 2018
10 Reads

18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee.

Clin Nucl Med 2018 Jan;43(1):55-56

From the Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC.

Malignant tumors of the sweat glands are exceedingly rare and aggressive tumors. We present here a case of a 60-year-old man with a malignant hidradenocarcinoma that developed in a background of preexisting benign hidradenoma on the lateral aspect of the knee that was initially resected, but rapidly recurred with associated inguinal lymphadenopathy. F-FDG PET/CT was performed as part of preoperative staging, which demonstrated abnormal inguinal lymph nodes and metastatic disease to the lungs. Read More

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http://dx.doi.org/10.1097/RLU.0000000000001903DOI Listing
January 2018
3 Reads

Ultrasonographic Features of Eccrine Spiradenoma.

J Ultrasound Med 2018 May 9;37(5):1267-1272. Epub 2017 Nov 9.

Departments of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

The purpose of this series was to evaluate the features of eccrine spiradenoma on ultrasonography (US). We reviewed the clinical data of 8 patients with eccrine spiradenoma who underwent preoperative US at 4 different medical institutions from 2004 to 2016 and analyzed the US features in terms of the tumor location, size, shape, margin, echo texture, echogenicity, posterior acoustic enhancement, calcification, septum, and color Doppler flow. There were 7 female patients and 1 male patient. Read More

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http://dx.doi.org/10.1002/jum.14460DOI Listing
May 2018
50 Reads

Eccrine Spiradenoma of the Scalp.

Arch Craniofac Surg 2017 Sep 26;18(3):211-213. Epub 2017 Sep 26.

Department of Pathology, Eulji University College of Medicine, Daejeon, Korea.

Eccrine spiradenoma is an uncommon benign adnexal tumor originating from the eccrine sweat gland. We diagnosed a eccrine spiradenoma on a 55-year-old man with histopathologic confirmation upon biopsy followed by complete resection, who had visited our clinic with a chief complain of occipital scalp mass. The solitary eccrine spiradenoma occurring in the scalp is rarely to be seen and should be considered as a differential diagnosis for a solitary cystic mass of the scalp. Read More

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http://dx.doi.org/10.7181/acfs.2017.18.3.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647852PMC
September 2017
22 Reads

A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance.

Hum Pathol 2017 12 24;70:55-61. Epub 2017 Oct 24.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan. Electronic address:

Hidradenoma usually presents as a solitary, slow-growing, and solid or cystic nodular lesion, which arises in various anatomical sites. Its diagnosis is occasionally difficult because the tumor shares histological features with other cutaneous appendage tumors. Recently, CRTC1-MAML2 fusion gene was reported in hidradenomas, with the fusion transcript being demonstrated in approximately 50% of cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177173037
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http://dx.doi.org/10.1016/j.humpath.2017.10.004DOI Listing
December 2017
18 Reads

Eccrine spiradenoma mimicking a painful traumatic neuroma: case report.

J Neurosurg 2018 09 27;129(3):825-828. Epub 2017 Oct 27.

2Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health.

Diagnosing and treating patients with persistent neuropathic pain associated with peripheral nerve lesions can be challenging. The authors report the rare case of a painful eccrine spiradenoma treated as a traumatic neuroma for many years because of a history of acute trauma, the presence of a tender palpable mass, and symptoms of allodynia. Surgical excision of the neoplasm completely relieved the pain and hypersensitivity that 2 prior surgeries and other nonsurgical treatments failed to resolve. Read More

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http://dx.doi.org/10.3171/2017.5.JNS162999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087503PMC
September 2018
36 Reads
3.740 Impact Factor

Hydroadenocarcinoma of clear cells located in the breast.

Cir Esp 2018 May 13;96(5):308-310. Epub 2017 Oct 13.

Hospital Universitario Fundación Jiménez Díaz, Madrid, España.

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https://linkinghub.elsevier.com/retrieve/pii/S0009739X173019
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http://dx.doi.org/10.1016/j.ciresp.2017.08.011DOI Listing
May 2018
7 Reads

Myoepithelial-Rich and Infiltrative Giant Vascular Eccrine Spiradenoma: A Unique Presentation of a Rare Adnexal Tumor.

Am J Dermatopathol 2018 Jun;40(6):428-432

Pathology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY.

A rare variant of the eccrine spiradenoma, the giant vascular eccrine spiradenoma, has been characterized as a large circumscribed and sometimes hemorrhagic solitary tumor occurring in adults older than 50 years. Histopathologically, the lesion is comprised of distinct cell populations and cystic hemorrhagic glandular spaces. We present a 68-year-old Bengali man with a giant vascular eccrine spiradenoma and describe immunohistochemical features of this tumor. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001007DOI Listing
June 2018
23 Reads

Large Eccrine Acrospiroma of the Hand.

J Clin Diagn Res 2017 Jul 1;11(7):PD15-PD16. Epub 2017 Jul 1.

Associate Professor, Department of General Surgery, Saveetha Medical College and Hospital, Kanchipuram, Tamil Nadu, India.

Eccrine acrospiroma are benign skin tumours of sweat duct origin. They usually present as small solid or cystic lesions which are confused clinically with other solid or cystic lesions. These are generally benign lesions with few reports of malignant transformation. Read More

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http://dx.doi.org/10.7860/JCDR/2017/27215.10246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583792PMC
July 2017
10 Reads

Sonographic Characteristics of Apocrine Nodular Hidradenoma of the Skin.

J Ultrasound Med 2018 Mar 7;37(3):793-801. Epub 2017 Sep 7.

Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile.

Nodular hidradenomas are benign sweat gland-derived tumors that can produce clinical and dermatoscopic misdiagnoses. Histologically, these tumors can be classified into eccrine and apocrine subtypes. We present the sonographic characteristics of 6 cases of apocrine nodular hidradenomas, which, to our knowledge, is so far the largest series reported. Read More

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http://dx.doi.org/10.1002/jum.14379DOI Listing
March 2018
31 Reads

Lymphangiectatic Variant of Eccrine Spiradenoma - A Diagnostic Challenge.

S D Med 2016 Aug;69(8):359-361

Sanford Pathology Clinic, Sioux Falls, South Dakota.

Conventional eccrine spiradenoma is a benign, slow growing and painful tumor of the skin. While the tumor does not usually present a diagnostic dilemma, a rare variant with marked stromal lymphedema can be a challenge to interpret. We present a case of lymphangiectatic variant of eccrine spiradenoma in an 82-year-old white male who presented with a persistent left flank lesion for several months. Read More

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August 2016
22 Reads

Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology.

Diagn Cytopathol 2018 Jan 3;46(1):59-62. Epub 2017 Aug 3.

Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi, India.

Limited literature is available on the use of fine needle aspiration (FNA) for skin tumors. Awareness of cytological features of these lesions is important to prevent misdiagnosis. A 45-year-old male, presented with slowly growing swelling over the thigh since 4 years. Read More

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http://dx.doi.org/10.1002/dc.23791DOI Listing
January 2018
18 Reads