Search Our Scientific Publications & Authors

J Immunol 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC;

The objective of this study is to determine the mechanism of action of anti-CD52 mAb treatment in patients with relapsing-remitting multiple sclerosis (RRMS). Experimental autoimmune encephalomyelitis (EAE), an animal model of the disease, was used to address the role of T regulatory cells (Tregs) in the anti-CD52 mAb-induced suppression of the disease. In vitro studies on PBMCs from RRMS patients and matched healthy controls determined the effect of IL-7 on the expansion of CD4CD25CD127 Tregs and induction of their suppressive phenotype. Read More

Arch Phys Med Rehabil 2022 Jun 21. Epub 2022 Jun 21.

Department of Neurological Surgery, University of Louisville, Louisville, KY, USA; Kentucky Spinal Cord Injury Research Center, Louisville, KY, USA. Electronic address:

Objective: To examine the efficacy, dosing, and safety profiles of intrathecal and oral baclofen in treating spasticity after spinal cord injury (SCI).

Data Sources: PubMed and Cochrane Databases were searched between 1970-2018 with keywords baclofen, spinal cord injury and efficacy.

Study Selection: The database search yielded 588 sources and 10 additional relevant publications. Read More

Life Sci 2022 Jun 21:120726. Epub 2022 Jun 21.

Institute of Neuroanatomy, Uniklinik RWTH Aachen, Aachen, Germany. Electronic address:

Aims: Spinal cord injury (SCI) is a debilitating neurological condition often associated with chronic neuroinflammation and redox imbalance. Oxidative stress is one of the main hallmark of secondary injury of SCI which is tightly regulated by nuclear factor E2-related factor 2/antioxidant response element (Nrf2/ARE) signaling. In this study, we aimed at investigating the interplay between inflammation-related miRNAs and the Nrf2 pathway in animal model of SCI. Read More

J Shoulder Elbow Surg 2022 Jun 21. Epub 2022 Jun 21.

Southern Oregon Orthopedics, Medford, OR, USA. Electronic address:

Background: The primary purpose of this study was to compare two-year anatomic total shoulder (TSA) functional and radiographic outcomes between Walch A and B glenoids treated with an all-polyethylene glenoid designed for hybrid fixation with peripheral cement and central osseous integration. The secondary purpose was to evaluate outcomes based on central peg technique. The hypotheses were that there would be no difference in short-term radiographic or functional outcome scores based on preoperative glenoid morphology or central peg technique. Read More

World Neurosurg 2022 Jun 21. Epub 2022 Jun 21.

Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University. Electronic address:

Objective: To analyze the efficacy and complications of spinal metastasis surgery for breast cancer; to understand the survival and the influencing factors; and to verify the predictive ability of the currently used spinal metastasis cancer survival prediction scoring system on the 1-year postoperative survival rate.

Methods: A retrospective study was conducted on 54 patients with spinal metastases from breast cancer who underwent open surgery after multidisciplinary consultation in our hospital from January 2017 to October 2020. Patient demographic-related variables, breast cancer-related variables, spinal disorders-related variables, and treatment-related variables were collected. Read More

Gene 2022 Jun 21:146689. Epub 2022 Jun 21.

Department of Orthopaedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin 300052, P.R. China; Department of Orthopaedics, Shandong University Centre for Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China. Electronic address:

Background: Ischemia-reperfusion injury (IRI) is an important pathophysiological condition that can cause cell injury and large-scale tissue injury in the nervous system. Previous studies have shown that epigenetic regulation may play a role in the pathogenesis of IRI.

Methods: In this study, we isolated mouse cortical neurons and constructed an oxygen-glucose deprivation/reoxygenation (OGD) model to explore the change in DNA methylation and its effect on the expression of corresponding genes. Read More

Endoscopy 2022 Jun 24. Epub 2022 Jun 24.

Department of Gastroenterology and Hepatology, Université catholique de Louvain, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Clin Neurol Neurosurg 2022 Jun 2;219:107318. Epub 2022 Jun 2.

Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Objective: To identify perioperative risk factors for postoperative delirium (POD) in patients aged 65 or older undergoing lumbar spinal fusion procedures.

Patients And Methods: A retrospective cohort analysis was performed on patients undergoing lumbar spinal fusion over an approximately three-year period at a single institution. Demographic and perioperative data were obtained from electronic medical records. Read More

J Spinal Cord Med 2022 Jun 24:1-9. Epub 2022 Jun 24.

Department of Kinesiology and Community Health, College of Applied Health Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Context/objective: To investigate predictors of participation enfranchisement of individuals living with spinal cord injury (SCI) who use a wheelchair full-time.

Design: Secondary data analysis of a cross-sectional study.

Setting: Community, United States. Read More

Sci Adv 2022 Jun 24;8(25):eabo1782. Epub 2022 Jun 24.

Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.

Little is known regarding T cell translational regulation. We demonstrate that T follicular helper (TFH) cells use a previously unknown mechanism of selective messenger RNA (mRNA) translation for their differentiation, role in B cell maturation, and in autoimmune pathogenesis. We show that TFH cells have much higher levels of translation factor eIF4E than non-TFH CD4 T cells, which is essential for translation of TFH cell fate-specification mRNAs. Read More

Proc Natl Acad Sci U S A 2022 Jun 24;119(26):e2118755119. Epub 2022 Jun 24.

Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032.

Retromer is a heteropentameric complex that plays a specialized role in endosomal protein sorting and trafficking. Here, we report a reduction in the retromer proteins-vacuolar protein sorting 35 (VPS35), VPS26A, and VPS29-in patients with amyotrophic lateral sclerosis (ALS) and in the ALS model provided by transgenic (Tg) mice expressing the mutant superoxide dismutase-1 G93A. These changes are accompanied by a reduction of levels of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA1, a proxy of retromer function, in spinal cords from Tg SOD1 mice. Read More

Rev Bras Med Vet 2022 12;44:e003921. Epub 2022 Apr 12.

Veterinarian, PhD, Head of Opsedale Veterinario San Michele, Tavazzano con Villavesco, (LO), Italy.

An adult neutered male Bengal tiger () presented with abnormal gait. Neurological examination showed poor left ambulatory hemiparesis, spontaneous proprioceptive deficit in the left anterior limb, and decreased flexor reflex in the forelimbs. The neurological symptoms suggested a caudal cervical spinal cord lesion. Read More

Rev Bras Med Vet 2021 22;43:e003321. Epub 2021 Nov 22.

Veterinarian, DSc. Faculdade Maurício de Nassau (Uninassau). Campus Natal, RN, Brazil.

Back pain and diseases of the spine are considered significant problems in equine sports and veterinary medicine. This article reports a multimodal approach to the treatment of equine back pain using ozonized platelet rich plasma (PRP), dynamic mobilization exercises, and therapeutic shoeing in 15 horses involved in the vaquejada discipline. Fifteen American Quarter Horses of both sexes engaged in vaquejada in the state of Rio Grande do Norte, Brazil, with a mean age of 8. Read More

Cell Mol Neurobiol 2022 Jun 24. Epub 2022 Jun 24.

College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, People's Republic of China.

Directed migration of neural stem cells (NSCs) is critical for embryonic neurogenesis and the healing of neurological injuries. The long noncoding RNA (lncRNA) Pnky has been reported to regulate neuronal differentiation of NSCs by interacting with PTBP1. However, its regulatory effect on NSC migration remains to be determined. Read More

Eur Spine J 2022 Jun 24. Epub 2022 Jun 24.

Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, No.59 Haier Road, Qingdao, 266000, Shandong, China.

Study Design: Clinical retrospective cohort study.

Objectives: To explore the application of the electromagnetic navigation system in Endo-TLIF.

Materials And Methods: From May 2019 to March 2020, 76 patients with single-segment lumbar spondylolisthesis treated by electromagnetic navigation-assisted Endo-TLIF (NE group) and conventional Endo-TLIF (CE group) were enrolled in the study. Read More

Pain Pract 2022 Jun 24. Epub 2022 Jun 24.

Nevro Corp, Redwood City, CA, USA.

Aims: The aim of our study was to review the surgical literature regarding the relationship between hemoglobin A1c (HbA1c), diagnosis of diabetes mellitus (DM), and risk of post-operative surgical site infection (SSI).

Methods: A librarian-assisted literature search was performed with two goals: 1) identify surgical publications related to SSI and HbA1c values, and 2) identify publications reporting infection risk with DM in spinal cord stimulation (SCS), intrathecal drug delivery systems (IDDS), and cardiovascular implantable electronic device (CIED) implantation surgeries. Published guidelines on perioperative management of DM are reviewed. Read More

J Fish Dis 2022 Jun 24. Epub 2022 Jun 24.

School of Fishery, Zhejiang Ocean University, Zhoushan, China.

In this study, we established and characterized a continuous cell line from the spinal cord tissue of mandarin fish, Siniperca chuatsi and assessed its susceptibility to infectious spleen and kidney necrosis virus (ISKNV), Siniperca chuatsi ranavirus (SCRaV) and Siniperca chuatsi rhabdovirus (SCRV). The cell line, named SCC, has been successively cultured up to 40 passages. The optimal growing conditions of SCC cells were in Leibovitz's L-15 medium supplemented with 20% foetal bovine serum (FBS) at 28°C. Read More

J Urol 2022 Jun 24:101097JU0000000000002836. Epub 2022 Jun 24.

Santa Clara Valley Medical Center, Department of Physical Medicine and Rehabilitation.

Introduction: In April 2008, Medicare amended their policy for clean intermittent catheter (CIC), increasing coverage from 4 re-used catheters per month to up to 200 single-use catheters. The primary reason for the policy change was an assumed decrease in risk of urinary tract infection (UTI) with single-use catheters. Given its economic/environmental impact (∼50-fold increase in cost and plastic waste) and a paucity of supporting evidence, we retrospectively evaluate the policies'effect in a prospective spinal cord injury (SCI) registry. Read More

Front Biosci (Landmark Ed) 2022 Jun;27(6):179

University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.

Introduction: Spinal muscular atrophy (SMA) is a progressive neurological disease with autosomal recessive transmission that affects motor neurons, causing their loss and resulting in muscle waste and motor deficiency. Nusinersen, the first SMN2 pre-mRNA targeted therapy approved by the Food and Drug Administration and the European Medicines Agency, has demonstrated high efficacy in improving motor function, as well as respiratory and nutritional statuses.

Materials And Methods: We observed 55 patients (children/adolescents) diagnosed with spinal muscular atrophy (SMA), who received nusinersen therapy. Read More

Yonsei Med J 2022 Jul;63(7):665-674

Department of Neurosurgery, The Spine and Spinal Cord Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study was undertaken to identify factors that affect segmental lordosis (SL) after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) by comparing patients whose postoperative SL increased with those whose decreased.

Materials And Methods: Fifty-five patients underwent MIS-TLIF at our institute from January 2018 to September 2019. Demographic, pre- and postoperative radiologic, and cage-related factors were included. Read More

J Neurotrauma 2022 Jun 23. Epub 2022 Jun 23.

1. KITE Research Institute, Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.

Egocentric video has recently emerged as a potential solution for monitoring hand function in individuals living with tetraplegia in the community, especially for its ability to detect functional use in the home environment. The aim of this study was to develop and validate a wearable vision-based system for measuring hand use in the home among individuals living with tetraplegia. Several deep learning algorithms for detecting functional hand-object interactions were developed and compared. Read More

FASEB J 2022 Jul;36(7):e22369

Lanzhou University Second Hospital, Lanzhou, PR China.

Intervertebral disc (IVD) degeneration (IVDD) is closely linked to degenerative spinal disease, resulting in disability, poor quality of life, and financial burden. Apoptosis of nucleus pulposus (NP) cells (NPCs) is a key pathological basis of IVDD. Periostin (POSTN), an extracellular matrix protein, is expressed in many tissues, whereas its abnormal expression is associated with IVDD. Read More

Artif Organs 2022 Jun 23. Epub 2022 Jun 23.

Department of Biomedical Engineering, Illinois Institute of Technology, United States.

Background: Intraspinal microstimulation (ISMS) has emerged as a promising neuromodulation technique for restoring standing and overground walking in individuals with spinal cord injury. Current and emerging ISMS implant designs connect the electrodes to the stimulator through lead wires that cross the dura mater. To reduce possible complications associated with transdural leads such as tethering and leakage of cerebrospinal fluid, we aim to develop a wireless, fully intradural ISMS implant based upon our prior work in the cortex with the Wireless Floating Microelectrode Array (WFMA). Read More

Front Oncol 2022 7;12:902928. Epub 2022 Jun 7.

SOC Chirurgia Vertebro-Midollare, Azienda Sanitaria Universitaria Friuli Centrale, Presidio Ospedaliero Universitario "Santa Maria della Misericordia" di Udine, Udine, Italy.

Introduction: The morbidity associated with metastatic spinal disease is significant because of spinal cord and/or nerve root compression. The purpose of this paper is to define a diagnostic-therapeutic path for patients with vertebral metastases and from this path to build an algorithm to reduce the devastating consequences of spinal cord compression.

Materials And Methods: The algorithm is born from the experience of a primary care center. Read More

Arthrosc Sports Med Rehabil 2022 Jun 24;4(3):e1083-e1089. Epub 2022 May 24.

Section of Young Adult Hip Surgery, Division of Sports Medicine, Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush University Medical Center, Chicago, Illinois, U.S.A.

Purpose: To compare joint distraction measured on ultrasound (US) with joint space width (JSW) measured on fluoroscopy in hip arthroscopy and to determine whether ultrasound guidance is as safe and effective as fluoroscopy, the current gold standard, for establishing arthroscopic portals.

Methods: Cadaveric whole-body specimens were positioned supine and subjected to 60 lbs. of unilateral axial traction using a distal femoral Steinman pin. Read More

Arthrosc Sports Med Rehabil 2022 Jun 24;4(3):e1103-e1110. Epub 2022 May 24.

Department of Orthopedic Surgery, Mayo Clinic, and Rochester, Minnesota.

Purpose: To determine whether conventional logistic regression or machine learning algorithms were more precise in identifying the risk factors for unplanned overnight admission after medial patellofemoral ligament (MPFL) reconstruction.

Methods: A retrospective review of the prospectively collected National Surgical Quality Improvement Program database was performed to identify patients who underwent outpatient MPFL reconstruction from 2006-2018. Patients admitted overnight were identified as those with length of stay of 1 or more days. Read More

J Chiropr Med 2022 Mar 9;21(1):60-65. Epub 2022 Jun 9.

Surgery, Midwest Spine & Brain Institute, Minneapolis, Minnesota.

Objective: The purpose of this case study is to describe chiropractic care of the cervical spine for a patient who previously underwent cervical total disk replacement (CTDR) of the C5-6 and C6-7 disks.

Clinical Features: A 42-year-old female veteran of the U.S. Read More

Neurol Clin Pract 2022 Jun;12(3):e28-e32

Departments of Neurology (LG, FRC, NLB, AV), Department of Neurosurgery (ADL), and Department of Pathology (Neuropathology) (SHG), University of Miami Miller School of Medicine, FL.

Objectives: Neurologic manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, COVID-19) infection are common and varied. The objective of this report was to describe clinicopathologic findings of rare acute ascending necrotizing myelitis (ANM) and briefly summarize similar COVID-19-associated longitudinally extended transverse myelitis cases.

Methods: We described the clinical presentation, disease course, diagnostic workup, therapeutic measures, and pathologic findings of ANM associated with COVID-19 infection. Read More

S Afr J Physiother 2022 27;78(1):1631. Epub 2022 May 27.

Department of Occupational Therapy, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Background: Community reintegration is a major outcome of rehabilitation after the acute phase in people with spinal cord injury (PWSCI).

Objective: To investigated clinical and socio-demographic factors determining community participation in PWSCI, living in the greater eThekwini Municipality, KwaZulu-Natal province.

Method: Our quantitative, cross-sectional study had a convenient sample of 41 PWSCI. Read More

Front Surg 2022 7;9:885989. Epub 2022 Jun 7.

Key Laboratory of Spinal Disease Research, Department of Orthopedic Surgery, Peking University Third Hospital, Peking University, Beijing, China.

Background: Recently, there have been some reports on surgical treatment for Klippel-Feil syndrome, but the prevalence and risk factors of surgery have not been well evaluated. This study sought to find the prevalence and potential risk factors of surgical treatment.

Methods: A retrospective radiographic review of 718 Klippel-Feil syndrome patients seen at Peking University Third Hospital from January 2010 to October 2017 was performed. Read More