25,247 results match your criteria Spinal Infections


The Utility of MRI Results in Physician Decision Making Prior to Initial Lumbar Spinal Injection.

Spine J 2019 Apr 19. Epub 2019 Apr 19.

University of Colorado Department of Physical Medicine and Rehabilitation, 12631 E. 17th Avenue, Mail Stop F493, Academic Office 1 (AO1), Room 2510, Aurora, Colorado 80045, US.

Background Context: The need for advanced imaging prior to spinal intervention is an area of ongoing debate. Many studies have demonstrated the accuracy of MRI results in evaluating structural pathology in the lumbar spine, but few have addressed how frequently MRI findings change clinical management. A randomized controlled trial showed that viewing MRI results did not impact outcomes in patients with radiculopathy undergoing epidural steroid injection (ESI). Read More

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http://dx.doi.org/10.1016/j.spinee.2019.04.016DOI Listing

A Retrospective Database Review of the Indications, Complications, and Incidence of Subsequent Spine Surgery in 12,297 Spinal Cord Stimulator Patients.

Neuromodulation 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.

Study Design: Retrospective review.

Objective: To analyze the indications, incidence of minor and major complications, and rate of subsequent spinal surgery or revision after spinal cord stimulator (SCS) placement for degenerative spine disease.

Summary Of Background Data: Despite the application of SCS in various chronic pain conditions, there remains a growing debate on the efficacy and necessity of SCS in degenerative spine disease. Read More

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http://dx.doi.org/10.1111/ner.12952DOI Listing

Endovascular treatment of a ruptured thoracic aortic pseudoaneurysm secondary to Pott disease during a spine surgery: A case report and a literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15306

Department of Orthopedic Surgery.

Rationale: The coexistence of a tuberculous aortic pseudoaneurysm and Pott disease in patients with a history of tuberculosis (TB) is relatively rare, and the treatment strategies remain still controversial.

Patient Concerns: A 57-year-old female patient with a history of primary pulmonary TB presented with symptoms of breathlessness, chest pain, weight loss, and fever. Magnetic resonance imaging (MRI) and computed tomography (CT) showed a thoracic aortic pseudoaneurysm secondary to Pott disease at T11/12 level. Read More

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http://dx.doi.org/10.1097/MD.0000000000015306DOI Listing

Intrasite Antibiotic Powder for the Prevention of Surgical Site Infection in Extremity Surgery: A Systematic Review.

J Am Acad Orthop Surg 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, Bethesda, MA.

Introduction: Although the role of intrasite antibiotic powder in preventing surgical site infections (SSIs) has been extensively explored in spinal surgery, it remains underevaluated in the other orthopaedic subspecialties. This systematic review examines the utilization of intrawound antibiotic powder as a prophylactic measure against SSIs in orthopaedic procedures.

Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, electronic searches were conducted on Ovid MEDLINE, and PubMed. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00475DOI Listing

Complications of Postoperative Epidural Analgesia for Oncologic Surgery: A Review of 18,895 Cases.

Clin J Pain 2019 Apr 18. Epub 2019 Apr 18.

The Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objectives: The risks of epidural analgesia differ depending on the population studied. We describe our experience with postoperative epidural analgesia for oncologic surgery.

Materials And Methods: After approval from the Institutional Review Board of The University of Texas MD Anderson Cancer Center to conduct this retrospective analysis, we searched our acute pain medicine database for cases in which postoperative epidural analgesia was used between 2003 and 2012. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000718DOI Listing

Association of pneumonia, wound infection and sepsis with clinical outcomes after acute traumatic spinal cord injury.

J Neurotrauma 2019 Apr 22. Epub 2019 Apr 22.

St. Michael's Hospital, Division of Neurosurgery, Toronto, Canada ;

Pneumonia, wound infections and sepsis (PWS) are the leading causes of acute mortality after traumatic spinal cord injury (SCI). However, the impact of PWS on neurological and functional outcomes is largely unknown. The present study analysed participants from the prospective North American Clinical Trials Network (NACTN) registry and the Surgical Timing in Acute SCI Study (STASCIS) for the association between PWS and functional outcome (assessed as Spinal Cord Independence Measure subscores for respiration and indoor ambulation) at 6 months postinjury. Read More

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http://dx.doi.org/10.1089/neu.2018.6245DOI Listing

Longitudinally extensive transverse myelitis in a patient infected with West Nile virus.

Mult Scler Relat Disord 2019 Apr 16;32:19-22. Epub 2019 Apr 16.

Clinic of Neurology, Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia; Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia. Electronic address:

Until now, longitudinally extensive transverse myelitis (LETM) was reported in association with various viral infections. We describe the case in which a diagnosis of LETM was established as a clinical manifestation of West Nile virus (WNV) infection. We report a 39-year old man with WNV infection and LETM. Read More

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http://dx.doi.org/10.1016/j.msard.2019.04.007DOI Listing

General vs Spinal Anesthesia for Revision Total Knee Arthroplasty: Do Complication Rates Differ?

J Arthroplasty 2019 Mar 28. Epub 2019 Mar 28.

Department of Orthopaedic Surgery, Emory University, Atlanta, GA.

Background: The incidence of both primary total knee arthroplasty (TKA) and revision TKA is increasing. Data from primary arthroplasty patients suggest a risk reduction with the use of spinal anesthesia when compared with general anesthesia. However, the same relationship has not been examined in the revision knee arthroplasty patient. Read More

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http://dx.doi.org/10.1016/j.arth.2019.03.048DOI Listing

Standalone Instrumented Posterior Approach Used as Universal Approach for Tuberculosis Spondylodiscitis.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):225-233

Department of Neurosurgery, AIIMS, Bhubaneswar, Odisha, India.

Background: Surgical management of spinal tuberculosis (TB) has been classically the anterior, then combined, and of late increasingly by the posterior approach. The posterior approach has been successful in early disease. There has been a paradigm shift and inquisitive to explore this approach in the more advanced and even long-segment disease. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_294_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454971PMC

Diffusion tensor imaging as an additional postoperative prognostic predictor factor in cervical myelopathy patients: An observational study.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):10-13

Department of Orthopaedics, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Introduction: Multiple investigation modalities have been invented for diagnosis and for planning management of degenerative cervical myelopathy, which include magnetic resonance imaging (MRI), computed tomography scan, and plain X-rays. Diffusion tensor imaging (DTI) of the spinal cord is a special variety of MRI where diffusion of water molecules across and along the tracts is mapped. The changes in anisotropy at the stenotic level can be a postoperative prognostic factor. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_77_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469325PMC

Treatment algorithm for spontaneous spinal infections: A review of the literature.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):3-9

Department of Human Neurosciences, Division of Neurosurgery, Sapienza University of Rome, Rome, Italy.

Background: Primary spinal infections are rare pathologies with an estimated incidence of 5% of all osteomyelitis. The diagnosis can be challenging and this might result in a late identification. The etiological diagnosis is the primary concern to determine the most appropriate treatment. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_115_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469318PMC

Cervical brucellar spondylitis causing incomplete limb paralysis.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180243. Epub 2019 Apr 11.

Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Brucellosis, a zoonosis with worldwide distribution, is a systemic infection caused by bacteria of the genus Brucella. Meanwhile, brucellosis often causes complications, such as osteoarticular involvement, and spondylitis is the most prevalent and important clinical form. Here, is a case of cervical brucellar spondylitis causing incomplete limb paralysis in a middle-aged male. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0037-8682-0243-2018DOI Listing
April 2019
3 Reads

Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study.

Trials 2019 Apr 16;20(1):223. Epub 2019 Apr 16.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, HP21 8AL, UK.

Background: Patients with lower neurogenic bladder dysfunction are at an increased risk of suffering from recurrent urinary tract infections. Recurrent symptomatic urinary tract infection is occasionally treated with antibiotics as a prophylactic prevention strategy. This risks increasing the frequency of antibiotic resistance. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3275-xDOI Listing
April 2019
4 Reads

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity.

Cureus 2019 Feb 1;11(2):e3994. Epub 2019 Feb 1.

Internal Medicine, Ocala Regional Medical Center/ University of Central Florida College of Medicine, Ocala, USA.

This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. Read More

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https://www.cureus.com/articles/17399-pancytopenia-as-a-cons
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http://dx.doi.org/10.7759/cureus.3994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443538PMC
February 2019
2 Reads

Efficacy of local wound infiltration analgesia with ropivacaine and dexmedetomidine in tubercular spine surgery - A pilot randomised double-blind controlled trial.

Indian J Anaesth 2019 Mar;63(3):182-187

Department of Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

Background And Aims: Regional analgesic techniques are difficult to use in tubercular spine patients due to distorted spinal anatomy and presence of infection. This study was conducted with the aim to evaluate analgesic efficacy of local wound infiltration before wound closure in tubercular spine patients.

Methods: This pilot randomised double-blind controlled study was conducted in 32 American Society of Anesthesiologists I-III patients, age ≥15 years, undergoing elective surgery for spinal tuberculosis. Read More

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http://dx.doi.org/10.4103/ija.IJA_780_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423940PMC
March 2019
1 Read

Care Bundle Approach to Minimizing Infection Rates after Neurosurgical Implants for Neuromodulation: A Single Surgeon Experience.

World Neurosurg 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, U.S. Department of Veterans Affairs Medical Center, Milwaukee, WI 53295; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226.

Introduction: Implant-related infections carry a high morbidity. Infectious rates for neuromodulation implants range from 1-9% for DBS, 0-10% for SCS systems, and 3-15% for IT pump systems. Meanwhile, studies on care bundles report infection rate reduction to 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.003DOI Listing

Update in Hospital Medicine: Practical Lessons from Current Literature.

J Hosp Med 2019 Apr 8;14:E1-E5. Epub 2019 Apr 8.

Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Hospital medicine continues to grow in workforce, clinical scope, and academic inquiry. This article provides a summary of recent high-impact publications for busy clinicians who provide care to hospitalized adults.

Methods: Authors reviewed articles that were published between March 2017 and March 2018 for the Update in Hospital Medicine presentations at the 2018 Society of Hospital Medicine and Society of General Internal Medicine annual meetings. Read More

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https://www.journalofhospitalmedicine.com/jhospmed/article/1
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http://dx.doi.org/10.12788/jhm.3206DOI Listing
April 2019
2 Reads

A case report of intraventricular and intrathecal tigecycline infusions for an extensively drug-resistant intracranial Acinetobacter baumannii infection.

Medicine (Baltimore) 2019 Apr;98(15):e15139

Department of Infectious Disease.

Rationale: The treatment of intracranial Acinetobacter baumannii infections is made difficult by multidrug-resistance poor drug penetration through the blood-brain barrier (BBB). Although tigecycline appears to be effective against A baumannii, it is only administered intravenously because it does not readily cross the BBB. The addition of intraventricular (IVT) or intrathecal infusions of tigecycline could revolutionize clinical therapy for intracranial A baumannii infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000015139DOI Listing

Treatment experience for full-thickness wound dehiscence with cerebrospinal fluid leakage following posterior primary spine surgery: Three case reports.

Medicine (Baltimore) 2019 Apr;98(15):e15126

Department of Orthopedics, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Rationale: Full-thickness wound dehiscence with cerebrospinal fluid (CSF) leakage following posterior spine surgery is a rare but troublesome complication. In the present study, 3 clinical cases associated with this entity are reported.

Patient Concerns: The first case developed incision effusion 5 days after posterior decompression and internal fixation for lumbar spinal stenosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000015126DOI Listing
April 2019
1 Read

Intrawound Treatment for Prevention of Surgical Site Infections in Instrumented Spinal Surgery: A Systematic Comparative Effectiveness Review and Meta-Analysis.

Global Spine J 2019 Apr 26;9(2):219-230. Epub 2018 Jul 26.

Department of Orthopaedics, University Medical Center Utrecht, Utrecht, Netherlands.

Study Design: Systematic review and meta-analysis.

Objectives: To determine the efficacy of intrawound treatments in reducing deep surgical site infections (SSIs) in instrumented spinal surgery.

Methods: The electronic databases MEDLINE, EMBASE, and Cochrane were systematically searched for intrawound treatments for the prevention of SSIs in clean instrumented spine surgery. Read More

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http://dx.doi.org/10.1177/2192568218786252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448203PMC

Harboring Contaminants in Repeatedly Reprocessed Pedicle Screws.

Global Spine J 2019 Apr 25;9(2):173-178. Epub 2018 Jun 25.

Cedars-Sinai Medical Center, Los Angeles CA, USA.

Study Design: It consisted of evaluation of the pedicle screws for presence of residual nonmicrobial contaminants and tabulation of the minimum steps and time required for reprocessing implants as per guidelines and its comparison with actual practice.

Objective: An evaluation of the nonmicrobial contaminants prevalent on the pedicle screws used for spine surgery and the underlying practice cause behind the source.

Methods: The first component consisted of a random selection of 6 pedicle screws and its assessment using optical microscopy, scanning electron microscopy with energy dispersive spectroscopy, and Fourier transform infrared spectroscopy. Read More

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http://dx.doi.org/10.1177/2192568218784298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448207PMC
April 2019
1 Read

[Comparison of the effectiveness of vertebral arch replantation and laminectomy in the treatment of mild to moderate isthmic spondylolisthesis].

Authors:
Ke Shao Lixin Ji

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):423-429

Department of Spine Surgery, Linyi People's Hospital, Linyi Shandong, 276003,

Objective: To compare the effectiveness of vertebral arch replantation and laminectomy in the treatment of mild to moderate isthmic spondylolisthesis.

Methods: The clinical data of 66 patients with isthmic spondylolisthesis treated with vertebral arch replantation or laminectomy between March 2014 and July 2016 were retrospectively analyzed. They were divided into trial group (34 cases, treated with complete replantation of vertebral arch, intervertebral fusion, and internal fixation) and control group (32 cases, treated with laminectomy with intervertebral fusion and internal fixation) according to different surgical methods. Read More

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http://dx.doi.org/10.7507/1002-1892.201807109DOI Listing

Focal Intramedullary Spinal Cord Lesion in HIV/AIDs: Toxoplasmosis vs. Lymphoma.

World Neurosurg 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurosurgery, Santa Clara Valley Medical Center, San Jose, CA 95128; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305. Electronic address:

Background: Neurological complications are common in HIV/AIDS patients. While both the central nervous system (CNS) and the peripheral nervous system (PNS) can be affected, up to 80% of HIV/AIDS patients have CNS involvement during the course of their illness. The brain is the primary site of HIV/AIDS associated CNS complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193104
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http://dx.doi.org/10.1016/j.wneu.2019.04.057DOI Listing
April 2019
2 Reads

Simultaneous explantation and implantation of intrathecal pumps: a case series.

J Neurosurg 2019 Apr 12:1-7. Epub 2019 Apr 12.

OBJECTIVEIntrathecal drug delivery devices (IDDDs) are a mainstay in the treatment of spasticity and refractory pain. While these devices have been shown to greatly improve the quality of life for patients, they also have a high perioperative complication and failure rate. A major complication of IDDD implantation is infection. Read More

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http://dx.doi.org/10.3171/2019.1.JNS18919DOI Listing
April 2019
4 Reads

Infection after spinal surgery and procedures.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):173-178

Department of Orthopaedics and Trauma Surgery, University Campus Bio-Medico of Rome, Rome, Italy.

Postoperative infections after spinal surgery are a challenging issue, difficult to diagnose and treat, that requires prolonged medical therapy and even surgery. In this paper, we aim to review the current standards in the diagnosis and treatment of post-procedural Spondylodiscitis (SD). We performed a review of the available literature focusing on diagnostic and therapeutic standards of post-procedural SD, both after minimally invasive procedures and open surgery. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17487DOI Listing
April 2019
1 Read

A systematic review: characteristics, complications and treatment of spondylodiscitis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):117-128

Department Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

Objective: This systematic review focuses on 5 key elements that may improve the decision-making process in spondylodiscitis: the infective agent, segmental instability, abscess development, neurological compromise and focus of infection.

Materials And Methods: We included 64 studies published between May 2012 and May 2017, that reported both a description of the discitis and comparative data regarding the disease and its complications.

Results: The majority of cases were caused by Staphylococcus spp (40. Read More

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http://www.europeanreview.org/article/17481
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http://dx.doi.org/10.26355/eurrev_201904_17481DOI Listing
April 2019
4 Reads

Cervical spondylodiscitis mimicking Pott's disease: a case report.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):1-5

Department of Medical and Surgical Sciences, University Magna Græcia, Catanzaro, Italy.

Introduction: The leading cause of pyogenic vertebral osteomyelitis is Staphylococcus aureus, and its incidence is rising, particularly in the elderly. We report an unusual case of cervical spondylodiscitis and epidural abscess mimicking Pott's disease.

Case Report: A 67-year-old man was admitted to our institution with a 15-day history of neck pain radiating to the head, shoulders and left arm that was associated with weakness and paresthesia. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17467DOI Listing
April 2019
1 Read

Medicinal chemistry of Alternative therapeutics: Novelty and hopes with genus Ammannia.

Curr Top Med Chem 2019 Apr 11. Epub 2019 Apr 11.

Laboratory of Chemistry, Department of Applied Sciences, Rajkiya Engineering College (An associate college of Dr. A.P.J. Abdul Kalam Technical University, Lucknow), Churk, Sonbhadra-231206. India.

The plants have formed the basis of folklore remedy since beginning of human civilization. The cumulative human endeavor and experience over a period of thousands of years developed into well to organize traditional medicine systems viz. Ayurvedic, Unani, Chinese amongst others. Read More

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http://dx.doi.org/10.2174/1568026619666190412101047DOI Listing

Fatigue, depression, and quality of life in children with multiple sclerosis: a comparative study with other demyelinating diseases.

Dev Med Child Neurol 2019 Apr 11. Epub 2019 Apr 11.

Pediatric Neurology Department, National Referral Center for Rare Inflammatory Brain and Spinal Diseases, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France.

Aim: To evaluate fatigue, depression, and quality of life (QoL) of children with multiple sclerosis and compare to other acute demyelinating syndromes (ADS).

Method: Children followed in the National Referral Centre of rare inflammatory brain and spinal diseases were included in this study. The Expanded Disability Status Scale, the fatigue severity scale, the Multiscore Depression Inventory for Children, and the Pediatric Quality of Life Inventory were used for evaluation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dmcn.14242
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http://dx.doi.org/10.1111/dmcn.14242DOI Listing
April 2019
2 Reads

A Novel Pharyngeal Clearance Maneuver for Initial Tracheostomy Tube Cuff Deflation in High Cervical Tetraplegia.

Am J Phys Med Rehabil 2019 Apr 17. Epub 2019 Apr 17.

Rehabilitation Research Center at Santa Clara Valley Medical Center, San Jose, CA.

Mechanical insufflation-exsufflation (MIE), or "cough-assist" is a commonly used method of clearing tracheal and pulmonary secretions in patients with respiratory insufficiency secondary to spinal cord injury (SCI). This report presents a novel technique termed the Pharyngeal Clearance Maneuver (PCM) which utilizes a modified application of the MIE device to mobilize "secretion burden" at the portion of the trachea above the tracheostomy cuff during cuff deflation. Utilization of this strategy may reduce the risk of aspiration, infection, and respiratory compromise for patients with high cervical SCI in the acute rehabilitation setting. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001192DOI Listing
April 2019
1 Read

Short-term Outcomes Following Cervical Laminoplasty and Decompression and Fusion with Instrumentation.

Spine (Phila Pa 1976) 2019 Apr 8. Epub 2019 Apr 8.

Division of Spinal Surgery/Departments of Orthopaedic and Neurosurgery, NYU Medical Center, NY Spine Institute, New York, NY, USA.

Study Design: Retrospective review of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database years 2010-2015.

Objective: Investigate which short-term outcomes differ for cervical laminoplasty and laminectomy and fusion surgeries.

Summary Of Background Data: Conflicting reports exist in spine literature regarding short-term outcomes following cervical laminoplasty and posterior laminectomy and fusion. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003057DOI Listing
April 2019
1 Read

A systematic review of the content and quality of clinical practice guidelines for management of the neurogenic bladder following spinal cord injury.

Spinal Cord 2019 Apr 10. Epub 2019 Apr 10.

BehaviourWorks Australia, Monash Sustainable Development Institute, Monash University, Melbourne, Australia.

Introduction: Neurogenic bladder following acute spinal cord injury (SCI) increases urinary tract infection (UTI) risk and affects quality of life and health system costs.

Objectives: This study aimed to identify, describe and evaluate quality of clinical practice guidelines (CPGs) for managing neurogenic bladder following SCI.

Methods: A comprehensive search covered six electronic databases (PubMed, Web of Science, Health Systems Evidence, Cochrane, CINAHL, Epistomonikos) and 12 CPG portals. Read More

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http://www.nature.com/articles/s41393-019-0278-0
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http://dx.doi.org/10.1038/s41393-019-0278-0DOI Listing
April 2019
3 Reads

SponDT (Spondylodiscitis Diagnosis and Treatment): spondylodiscitis scoring system.

J Orthop Surg Res 2019 Apr 11;14(1):100. Epub 2019 Apr 11.

Clinic of Trauma Hand- und Reconstructive Surgery, Friedrich-Schiller-University Jena, Jena, Germany.

Background: Spondylodiscitis is a chameleon among infectious diseases due to the lack of specific symptoms with which it is associated. It is nevertheless a serious infection, with 7% mortality of hospitalized patients, in large part because of delayed diagnosis. The aim of this study was to develop a diagnosis and course-of-disease index to optimize its treatment. Read More

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http://dx.doi.org/10.1186/s13018-019-1134-9DOI Listing

Management of Acquired Compressive Myelopathy due to Spinal Fluorosis.

Indian J Orthop 2019 Mar-Apr;53(2):324-332

Department of Orthopaedics, B J Medical College, Civil Hospital, Ahmedabad, Gujarat, India.

Background: Fluorosis is an endemic disease of India which causes compressive cervical and/or dorsal myelopathy. This study aims to evaluate the role of surgical management in the crippling fluorosis along with evaluation of radiological imaging as screening/diagnosing tool for the disease.

Materials And Methods: This is a prospective cohort study of 33 patients operated at tertiary care center having nontraumatic involvement of spinal cord affecting neurology with history, clinical and radiological features (Ossified Posterior Longitudinal Ligament-, Ossified Ligamentum flavum) suggesting fluorosis as the cause of compression. Read More

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http://dx.doi.org/10.4103/ortho.IJOrtho_570_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415559PMC
April 2019
2 Reads

Delayed Astrogliosis Associated with Reduced M1 Microglia Activation in Matrix Metalloproteinase 12 Knockout Mice during Theiler's Murine Encephalomyelitis.

Int J Mol Sci 2019 Apr 5;20(7). Epub 2019 Apr 5.

Department of Pathology, University of Veterinary Medicine Hannover; Center for Systems Neuroscience 30559 Hannover, Germany.

Theiler's murine encephalomyelitis (TME) represents a versatile animal model for studying the pathogenesis of demyelinating diseases such as multiple sclerosis. Hallmarks of TME are demyelination, astrogliosis, as well as inflammation. Previous studies showed that matrix metalloproteinase 12 knockout () mice display an ameliorated clinical course associated with reduced demyelination. Read More

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http://dx.doi.org/10.3390/ijms20071702DOI Listing
April 2019
4 Reads

Biportal Endoscopic Spinal Surgery for Lumbar Spinal Stenosis.

Asian Spine J 2019 Apr 30;13(2):334-342. Epub 2019 Apr 30.

Spine Center, Himnaera Hospital, Busan, Korea.

Biportal endoscopic spinal surgery (BESS) is a minimally invasive spinal surgery, which is basically similar to microscopic spinal surgery in terms of the use of floating technique and technically similar to conventional percutaneous endoscopic spinal surgery in terms of the use of endoscopic or arthroscopic instruments. Using two independent portals (viewing and working) and maintaining a certain distance from the bony and neural structures allow closer access to the target lesion through a panoramic view by free handling of the scope and instruments rather than through a fixed view by docking into the Kambin's triangle. Minimally invasive surgery allows for reduced dissection and inevitable muscle injury, preserving stability and reducing risks of restabilization. Read More

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http://dx.doi.org/10.31616/asj.2018.0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454273PMC
April 2019
2 Reads

Disseminated central nervous system infection after lung transplantation: A case report with successful recovery.

Med Mycol Case Rep 2019 Jun 16;24:37-40. Epub 2019 Mar 16.

Department of Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Finland.

species are fungal opportunistic pathogens frequently seen in chronic lung diseases such as in cystic fibrosis (CF). They can cause a wide spectrum of diseases mainly in immunodeficient patients. Invasive, disseminated infections with poor prognosis have been described after lung transplantation. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431731PMC
June 2019
2 Reads

[Microscopic keyhole technique for surgical resection of thoracic spinal meningioma via an oblique placing tube].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(13):983-987

Division of Spine Surgery and Electrophysiological Center, Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China.

To report the methods and clinical outcomes of microscopic minimally invasive keyhole technique for surgical resection of thoracic spinal meningiomas. Thirty-nine patients with thoracic spinal meningiomas received keyhole surgery from May 2013 to June 2017 in the Department of Spine Surgery, Fujian Provincial Hospital. A working channel with a diameter of 1. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.13.005DOI Listing
April 2019
2 Reads

30-day Outcomes in Primary vs. Revision Posterior Spinal Fusion for Pediatric Spinal Deformity.

Clin Neurol Neurosurg 2019 May 1;180:106-110. Epub 2019 Apr 1.

Department of Orthopaedics, The Ohio State University Wexner Medical Center, United States. Electronic address:

Objectives: Current evidence, with regard to primary vs. revision spinal fusions in pediatric spine deformities, is limited to inpatient outcomes only. The current study aims to analyze and compare 30-day outcomes in pediatric spine deformity patients undergoing a primary vs. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.023DOI Listing
May 2019
1 Read

Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors.

Cell Death Differ 2019 Apr 5. Epub 2019 Apr 5.

Brain and Spinal Cord Innovative Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.

It remains largely unknown how Zika virus (ZIKV) infection causes severe microcephaly in human newborns. We examined an Asian lineage ZIKV, SZ01, which similarly infected and demonstrated comparable growth arrest and apoptotic pathological changes in human neuroprogenitors (NPCs) from forebrain dorsal, forebrain ventral as well as hindbrain and spinal cord brain organoids derived from human pluripotent stem cells. Transcriptome profiling showed common overactivated antiviral response in all regional NPCs upon ZIKV infection. Read More

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http://dx.doi.org/10.1038/s41418-019-0324-7DOI Listing

Risk factors for febrile genito-urinary infection in the catheterized patients by with spinal cord injury-associated chronic neurogenic lower urinary tract dysfunction evaluated by urodynamic study and cystography: a retrospective study.

World J Urol 2019 Apr 4. Epub 2019 Apr 4.

Division of Urology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan.

Introduction: To investigate the risk factors for febrile genito-urinary tract infection (GUTI) in spinal cord injury-associated neurogenic lower urinary tract dysfunction (NLUTD) patients who perform routine clean intermittent catheterization (CIC) evaluated by urodynamic study (UDS) and cystography.

Patients And Methods: Over a 3-year period, we retrospectively assessed risk factors for febrile UTI in 141 spinal cord injury patients diagnosed as NLUTD and performing routine CIC, regarding gender, UDS findings such as bladder compliance, maximum cystometric capacity, and cystography.

Results: A total of 41 patients had febrile GUTI in the follow-up period as along with 32 cases of pyelonephritis, 10 cases of epididymitis, and 1 case of prostatitis, including patients with multiple infectious diseases. Read More

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http://dx.doi.org/10.1007/s00345-019-02743-5DOI Listing
April 2019
2 Reads

Brain Infection by Hepatitis E Virus Probably via Damage of the Blood-Brain Barrier Due to Alterations of Tight Junction Proteins.

Front Cell Infect Microbiol 2019 19;9:52. Epub 2019 Mar 19.

Laboratory of Animal Pathology and Public Health, Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Extrahepatic injury, particularly neurologic dysfunctions such as Guillain-Barré syndrome, neurologic amyotrophy, and encephalitis/meningoencephalitis/myositis were associated with HEV infection, which was supported by both clinical and laboratory studies. Thus, it is crucial to figure out how the virus invades into the central nervous system (CNS). In this study, CNS lesions were determined in rabbits and Mongolian gerbils inoculated with genotype 4 HEV. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436201PMC
March 2019
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Empyema and pyogenic spondylitis caused by direct Streptococcus gordonii infection after a compression fracture: a case report.

Surg Case Rep 2019 Apr 3;5(1):52. Epub 2019 Apr 3.

Department of Orthopedics, National Hospital Organization Matsumoto Medical Center, 2-20-30 Murai-Machi-Minami, Matsumoto, 399-0021, Japan.

Background: Empyema and pyogenic spondylitis are common diseases that are often caused by oral pathogens in direct or hematogenous infection. However, there exists no report describing empyema and pyogenic spondylitis caused by oral pathogens after a compression fracture of the vertebral body. Herein, we report a case of empyema and pyogenic spondylitis caused by direct Streptococcus gordonii infection after a compression fracture of the vertebral body. Read More

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http://dx.doi.org/10.1186/s40792-019-0613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447627PMC
April 2019
2 Reads

Post-carbon-ion radiotherapy vertebral pathological fractures in upper cervical primary malignant spinal tumors treated by occipito-cervical fusion.

Arch Orthop Trauma Surg 2019 Apr 3. Epub 2019 Apr 3.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

Purpose: To describe the characteristic features of post-carbon-ion radiotherapy (CIRT) vertebral pathological fractures (VPFs) in upper cervical primary malignant spinal tumors (PMSTs) treated by occipito-cervical (OC) fusion.

Methods: OC fusion was performed for three consecutive patients with post-CIRT VPFs. The clinical results and imaging findings, including bone single-photon emission computed tomography (SPECT)/CT were prospectively collected. Read More

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http://dx.doi.org/10.1007/s00402-019-03183-xDOI Listing
April 2019
2 Reads

OTUB1 inhibits CNS autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes.

EMBO J 2019 Apr 3. Epub 2019 Apr 3.

Institute of Medical Microbiology and Hospital Hygiene, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Astrocytes are critical regulators of neuroinflammation in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Growing evidence indicates that ubiquitination of signaling molecules is an important cell-intrinsic mechanism governing astrocyte function during MS and EAE Here, we identified an upregulation of the deubiquitinase OTU domain, ubiquitin aldehyde binding 1 (OTUB1) in astrocytes during MS and EAE Mice with astrocyte-specific OTUB1 ablation developed more severe EAE due to increased leukocyte accumulation, proinflammatory gene transcription, and demyelination in the spinal cord as compared to control mice. OTUB1-deficient astrocytes were hyperactivated in response to IFN-γ, a fingerprint cytokine of encephalitogenic T cells, and produced more proinflammatory cytokines and chemokines than control astrocytes. Read More

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http://dx.doi.org/10.15252/embj.2018100947DOI Listing
April 2019
2 Reads

A Pilot Study of Percutaneous Interlaminar Endoscopic Lumbar Sequestrectomy: A Modern Strategy to Tackle Medically-Refractory Radiculopathies and Restore Spinal Function.

Neurospine 2019 Mar 31;16(1):120-129. Epub 2019 Mar 31.

Neurosurgical Clinic, Department of Neurosciences, University of Messina, Messina, Italy.

Objective: Angled scopes allow 360° visualization, which makes percutaneous endoscopic techniques (percutaneous endoscopic lumbar discectomy, PELD) particularly attractive for sequestrectomies, which entail the removal of extruded lumbar disc fragments that have migrated caudally or cranially between the ligaments, foramina, and neural structures, while preserving the disc. Although many different PELD techniques are currently available, not all of them are suitable for sequestrectomies; furthermore, long-term follow-up data are unfortunately lacking.

Methods: A pilot study was conducted on a cohort of 270 patients with lumbar radiculopathy undergoing minimally invasive spine surgery (PELD or microdiscectomy), of whom only 7 were eligible for endoscopic interlaminar sequestrectomy with disc preservation. Read More

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http://dx.doi.org/10.14245/ns.1836210.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449818PMC
March 2019
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The Concept for A Standalone Lordotic Endoscopic Wedge Lumbar Interbody Fusion: The LEW-LIF.

Neurospine 2019 Mar 31;16(1):82-95. Epub 2019 Mar 31.

Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Objective: To review concepts of a standalone endoscopically assisted lumbar interbody fusion as a simplified method to treat spinal instability.

Methods: MacNab outcomes and complications were analyzed in a series of 48 consecutive patients who underwent standalone lordotic endoscopic wedge lumbar interbody fusion (LEW-LIF) for advanced lumbar disc degeneration, spinal stenosis, and spondylolisthesis.

Results: Forty-two of the 48 patients (77. Read More

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http://dx.doi.org/10.14245/ns.1938046.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449821PMC
March 2019
1 Read