25,034 results match your criteria Spinal Infections


Investigation of Fibronectin Binding Protein (FBP) and Panton Valentine Leukocidin (PVL) Viulance Factors in Clinical Methicillin Sensitive and Resistant Staphylococcus Aureus Strains.

Clin Lab 2019 Jan;65(1)

Background: We aimed to investigate the frequency of fibronectin binding protein (FBP), which is part of the first step of adhesion, and Panton-Valentine leukocidin (PVL) toxin, which contributes to the destruction of host leukocytes and tissue necrosis, in clinical S. aureus strains.

Methods: One hundred S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180625DOI Listing
January 2019

Efficacy of Intraoperative Implant Prophylaxis in Reducing Intraoperative Microbial Contamination.

Global Spine J 2019 Feb 12;9(1):62-66. Epub 2018 Jun 12.

University of Toledo, Toledo, OH, USA.

Study Design: A prospective single-center study.

Objectives: Assess to what degree contamination of pedicle screws occur in standard intraoperative practice and if use of an impermeable guard could mitigate or reduce such an occurrence.

Methods: Two groups of sterile prepackaged pedicle screws, one with an intraoperative guard (group 1) and the other without such a guard (group 2), each consisting of 5 samples distributed over 3 time points, were loaded onto the insertion device by the scrub tech and left on the sterile table. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2192568218780676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362554PMC
February 2019

Early and Late Reoperation Rates With Various MIS Techniques for Adult Spinal Deformity Correction.

Global Spine J 2019 Feb 10;9(1):41-47. Epub 2018 May 10.

University of California, San Francisco, CA, USA.

Study Design: A multicenter retrospective review of an adult spinal deformity database.

Objective: We aimed to characterize reoperation rates and etiologies of adult spinal deformity surgery with circumferential minimally invasive surgery (cMIS) and hybrid (HYB) techniques.

Methods: Inclusion criteria were age ≥18 years, and one of the following: coronal Cobb >20°, sagittal vertical axis >5 cm, pelvic tilt >20°, and pelvic incidence-lumbar lordosis >10°. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2192568218761032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362559PMC
February 2019

Tetraplegia associated with post-operative syringomyelia in spinal tuberculosis: a result of an epidural compartment syndrome?

Spinal Cord Ser Cases 2019 12;5:18. Epub 2019 Feb 12.

Department of Orthopaedics, Max Smart Super Specialty Hospital, New Delhi, India.

Introduction: The commonly recognized causes of post-operative neurological deterioration in spinal tuberculosis are inadequate decompression, damage to vascular supply of the spinal cord, and multi-drug resistant organisms. There are no known cases of syringomyelia developing after surgical decompression of spinal tuberculosis.

Case Presentation: A teenage girl presented with rapid onset quadriparesis secondary to a tubercular epidural abscess extending from C4-T8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41394-019-0159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372701PMC
February 2019

The role of Technetium-99m-Ethambutol scintigraphy in the management of spinal tuberculosis.

World J Nucl Med 2019 Jan-Mar;18(1):13-17

Departement of Nuclear Medicine and Molecular Imaging, Faculty of Medicine, Dr. Hasan Sadikin Hospital, Padjadjaran University, Bandung, Indonesia.

Spines is a common site of extrapulmonary Mycobacterium tuberculosis infection (MTI). Spine destruction due to MTI can mimic other etiologies. Treatment of choice for spinal tuberculosis (STB) is anti-TB drugs while surgery could be needed in other causes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1450-1147.250325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357715PMC
February 2019

RADIOACTIVE CEMENT OF PMMA AND HAP-Sm-153, Ho-166, OR RE-188 FOR BONE METASTASIS TREATMENT.

Acta Ortop Bras 2019 Jan-Feb;27(1):64-68

Department of Nuclear Engineering, Laboratório Núcleo de Radiações Ionizantes, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Polymethylmetacrylte (PMMA) is used in the fields of dentistry and biomedicine as a constituent of bone cements. Hydroxyapatite (HAp) is a bioceramic produced naturally in the bones. PMMA and HAp are fundamental constituents in the preparation of bone cements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1413-785220192701190288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362695PMC
February 2019

Surveillance of tuberculosis (TB) cases attributable to relapse or reinfection in London, 2002-2015.

PLoS One 2019 15;14(2):e0211972. Epub 2019 Feb 15.

Field Service, National Infection Service, Public Health England, London, United Kingdom.

Recurrence of TB in an individual can occur due to relapse of the same strain or reinfection by a different strain. The contribution of reinfection and relapse to TB incidence, and the factors associated with each are unknown. We aimed to quantify and describe cases attributable to relapse or reinfection, and identify associated risk factors in order to reduce recurrence. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211972PLOS
February 2019

Comparison of All-Cause and Cause-Specific Mortality of Persons with Traumatic Spinal Cord Injuries to the General Swiss Population: Results from a National Cohort Study.

Neuroepidemiology 2019 Feb 14;52(3-4):205-213. Epub 2019 Feb 14.

Swiss Paraplegic Research, Nottwil, Switzerland.

Background: Traumatic spinal cord injuries (TSCI) are a neurological condition associated with reduced well-being, increased morbidity and reductions in life expectancy. Estimates of all-cause and cause-specific mortality can aid in identifying targets for prevention and management of contributors for premature mortality.

Objectives: To compare all-cause and cause-specific rates of mortality to that of the Swiss general population; to identify differentials in risk of cause-specific mortality according to lesion characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496976DOI Listing
February 2019

Neutrophil to Lymphocyte Ratio and Mortality in Spinal Epidural Abscess.

Spine J 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School. Electronic address:

Background Context: Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio have been previously identified as markers for overall survival in oncology but remain heretofore unexplored in spinal epidural abscess (SEA).

Purpose: The purpose of this study was to determine the impact of these routinely collected assessments on ninety-day mortality in SEA.

Study Design/setting: Retrospective, case-control study PATIENT SAMPLE: Patients 18 years or older diagnosed with SEA at two academic medical centers and three community hospitals OUTCOME MEASURES: Ninety-day post-discharge and in-hospital mortality METHODS: Complete blood count with differential obtained on the day immediately preceding or on the day of admission was used to calculate platelet to lymphocyte and neutrophil to lymphocyte ratios. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.spinee.2019.02.005DOI Listing
February 2019

Determining Best Practices for Management of Bacteriuria in Spinal Cord Injury: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2019 Feb 14;8(2):e12272. Epub 2019 Feb 14.

Center for Innovations in Quality, Effectiveness and Safety, Houston, TX, United States.

Background: Bacteriuria, either asymptomatic (ASB) or symptomatic, urinary tract infection (UTI), is common in persons with spinal cord injury (SCI). Current Veterans Health Administration (VHA) guidelines recommend a screening urinalysis and urine culture for every veteran with SCI during annual evaluation, even when asymptomatic, which is contrary to other national guidelines. Our preliminary data suggest that a positive urine culture (even without signs or symptoms of infection) drives antibiotic use. Read More

View Article

Download full-text PDF

Source
https://www.researchprotocols.org/2019/2/e12272/
Publisher Site
http://dx.doi.org/10.2196/12272DOI Listing
February 2019
2 Reads

Brain and Spinal Cord Lesions in Leprosy: A Magnetic Resonance Imaging-Based Study.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Neurotropism and infiltration by of peripheral nerves causing neuropathy are well established, but reports of central nervous system (CNS) damage are exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities of the brain and spinal cord as well as lesions in nerve roots and plexus in leprosy patients. Eight patients aged between 17 and 41 years underwent detailed clinical, histopathological, and MRI evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.17-0945DOI Listing
February 2019
1 Read

Commentary: Chlorhexidine Showers are Associated With a Reduction in Surgical Site Infection Following Spine Surgery: An Analysis of 4266 Consecutive Surgeries.

Neurosurgery 2018 Dec 11. Epub 2018 Dec 11.

The Spinal Column Biomechanics and Surgical Outcomes Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuros/nyy595DOI Listing
December 2018

Continuous Bilateral Erector of Spine Plane Block at T8 for Extensive Lumbar Spine Fusion Surgery: Case report.

Pain Pract 2019 Feb 13. Epub 2019 Feb 13.

Tondela Viseu Hospital Centre, Anesthesiology Service.Address: Centro Hospitalar Tondela Viseu, Anesthesiology Service, Serviço de Anestesiologia Rua Rei Dom Duarte, 3504-509, Viseu, Portugal.

Supplementary strategies, in combination with conventional analgesia, for pain control after lumbar fusion surgery remain limited. Here, we describe a 79-year-old woman who experienced pain (10/10 on a numerical rating scale) on post-operative day 1 after undergoing L2 to S1 spine fusion. Erector spinae plane (ESP) blocks were performed at T8 and, after a bolus of ropivacaine 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/papr.12774DOI Listing
February 2019

Multiple Exostoses Syndrome and Basilar Artery Aneurysm: A Case Report.

J Vasc Interv Neurol 2018 Nov;10(2):28-32

Department of Neurosurgery, University of Patras, Patras, Greece.

Background: Hereditary multiple exostoses (HME) is an inherited genetic condition, characterized by the formation of multiple osteochondromas, developing throughout childhood and into puberty. Vascular complications associated with HME are uncommon.

Methods: A case of a patient with HME who was admitted to hospital with subarachnoid hemorrhage (SAH), as a result of acute rupture of a basilar tip aneurysm (BTA), will be presented. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350870PMC
November 2018
1 Read

Acute idiopathic spinal subdural hematoma: What to do in an emergency?

Neurochirurgie 2019 Feb 8. Epub 2019 Feb 8.

Department of neurosurgery, Sainte Anne Military Hospital, France. Electronic address:

Acute spinal cord compression usually results from trauma, infection, or cancer. Spinal subdural hematoma is an uncommon cause of spinal cord compression that occurs after spine trauma or spinal invasive procedure, especially in context of coagulopathy. In the following reported case, an 82-year-old woman with a history of rapidly progressive paraparesis after a sudden middle back pain, with no previous trauma or coagulopathy, due to an acute spontaneous spinal subdural hematoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuchi.2018.10.009DOI Listing
February 2019
1 Read

TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.

PLoS Pathog 2019 Feb 11;15(2):e1007574. Epub 2019 Feb 11.

Departments of Neurology, University of Chicago Medical Center, Chicago, IL, United States of America.

TDP-43, an RNA-binding protein that is primarily nuclear and important in splicing and RNA metabolism, is mislocalized from the nucleus to the cytoplasm of neural cells in amyotrophic lateral sclerosis (ALS), and contributes to disease. We sought to investigate whether TDP-43 is mislocalized in infections with the acute neuronal GDVII strain and the persistent demyelinating DA strain of Theiler's virus murine encephalomyelitis virus (TMEV), a member of the Cardiovirus genus of Picornaviridae because: i) L protein of both strains is known to disrupt nucleocytoplasmic transport, including transport of polypyrimidine tract binding protein, an RNA-binding protein, ii) motor neurons and oligodendrocytes are targeted in both TMEV infection and ALS. TDP-43 phosphorylation, cleavage, and cytoplasmic mislocalization to an aggresome were observed in wild type TMEV-infected cultured cells, with predicted splicing abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007574DOI Listing
February 2019
2 Reads

Parvimonas micra Spondylodiscitis: A Case Report and Systematic Review of the Literature.

J Orthop Case Rep 2018 Sep-Oct;8(5):67-71

Department of Orthopaedic Surgery, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

Introduction: Treatment and risk factors for Parvimonas micra spinal infections are scarcely researched. This study reports a case and presents a systematic review of the literature to provide evidence-based ground for diagnosis and treatment of P. micra spinal infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13107/jocr.2250-0685.1216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367290PMC
February 2019
7 Reads

Infliximab biosimilar for treating neurosarcoidosis: tolerance and efficacy in a retrospective study including switch from the originator and initiation of treatment.

J Neurol 2019 Feb 9. Epub 2019 Feb 9.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'hôpital, 75651, Paris Cedex 13, France.

Objectives: Infliximab is increasingly used to treat neurosarcoidosis. We aimed to determine the efficacy and tolerance of an infliximab biosimilar for treating neurosarcoidosis.

Methods: We conducted a retrospective single-center study to describe the efficacy, safety and immunogenicity of an infliximab biosimilar in neurosarcoidosis patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-019-09234-yDOI Listing
February 2019
1 Read

Finegoldia magna causing intramedullary thoracic spinal cord abscess in an infant.

Anaerobe 2019 Feb 7. Epub 2019 Feb 7.

Pediatric Infectious Diseases Unit, Department of Pediatric, King Saud University Medical City, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Spinal intramedullary abscesses are rare and potentially devastating lesions. Infection is mostly caused by staphylococci. Anaerobes are rare and often polymicrobial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anaerobe.2019.02.002DOI Listing
February 2019

Astrocytes in Flavivirus Infections.

Int J Mol Sci 2019 Feb 6;20(3). Epub 2019 Feb 6.

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.

Virus infections of the central nervous system (CNS) can manifest in various forms of inflammation, including that of the brain (encephalitis) and spinal cord (myelitis), all of which may have long-lasting deleterious consequences. Although the knowledge of how different viruses affect neural cells is increasing, understanding of the mechanisms by which cells respond to neurotropic viruses remains fragmented. Several virus types have the ability to infect neural tissue, and astrocytes, an abundant and heterogeneous neuroglial cell type and a key element providing CNS homeostasis, are one of the first CNS cell types to get infected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20030691DOI Listing
February 2019
1 Read

MRI reveals segmental distribution of enterovirus lesions in the central nervous system: a probable clinical evidence of retrograde axonal transport of EV-A71.

J Neurovirol 2019 Feb 7. Epub 2019 Feb 7.

Guangzou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.

Enterovirus 71 (EV-A71) is a major causative agent for hand, foot, and mouth disease (HFMD), especially severe HFMD characterized by neurologic involvement. The objective of this study is to investigate the relationship between the distribution of neurologic infection and the outcomes of severe HFMD. A total of 139 suspected severe HFMD cases (92 were confirmed as EV-A71 infection) underwent clinical and laboratory diagnosis as well as magnetic resonance imaging (MRI) scans of the nervous system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13365-019-00724-3DOI Listing
February 2019
2 Reads

Application of Vancomycin Powder to Reduce Surgical Infection and Deep Surgical Infection in Spinal Surgery: A Meta-analysis.

Clin Spine Surg 2019 Feb 5. Epub 2019 Feb 5.

Graduate School of Tianjin Medical University.

Study Design: This was a meta-analysis study.

Objective: Our meta-analysis study aimed to evaluate the efficacy of vancomycin powder to reduce the surgical site infection (SSI) in spinal surgery.

Summary Of Background Data: The SSI is a potential and devastating complication after spinal surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BSD.0000000000000778DOI Listing
February 2019

Pregnancy outcomes in women with spinal cord injuries: a population-based study.

PM R 2019 Feb 6. Epub 2019 Feb 6.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Pregnant women with congenital or acquired spinal cord injury face challenges due to compromised neurological function and mobility; factors that may also affect fetal/infant health. Few studies have examined pregnancy course and longer-term outcomes in this population.

Objective: To assess pregnancy outcomes among women with spinal cord injury, paralysis, or spina bifida using population-based data. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/pmrj.12122
Publisher Site
http://dx.doi.org/10.1002/pmrj.12122DOI Listing
February 2019
2 Reads

Proximal femoral resection and Tensor Fascia Lata flap for recalcitrant trochanteric pressure ulcers.

Spinal Cord Ser Cases 2019 5;5:15. Epub 2019 Feb 5.

2Department of Anaesthesiology and Critical Care, Pt. B.D. Sharma PGIMS, Rohtak-124001 Haryana, India.

Introduction: Trochanteric pressure ulcers (PrUs) are difficult to treat and are often complicated by infection spreading to the hip joint. We review three cases from India where proximal femoral resection and pedicled Tensor Fascia Lata (TFL) flapping was used in the management of infected deep trochanteric ulcers communicating to the hip joint.

Case Presentation: Three patients had a total of four trochanteric PrUs communicating to the hip joint. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41394-019-0157-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363780PMC
February 2019

Outcome Following the Treatment of Ventriculitis Caused by Multi/Extensive Drug Resistance Gram Negative Bacilli; and .

Front Neurol 2018 23;9:1174. Epub 2019 Jan 23.

Neurosurgery Department, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

CNS ventriculitis is a serious complication following an intracranial insult that demands immediate treatment with broad-spectrum antibiotics in a critical care setting. Infections due to multi/extensive drug resistance (MDR/XDR) microorganisms are very challenging, which may demand an additional approach to the ongoing practice; intravenous and intraventricular administration of antibiotics. To study the efficacy and safety of thorough ventricular irrigation followed by daily intraventricular antibiotic administration in patients with MDR/XDR ventriculitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2018.01174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352847PMC
January 2019
1 Read

Multimodal imaging guides surgical management in a preclinical spinal implant infection model.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Department of Orthopedic Surgery, David Geffen School of Medicine at UCLA, Santa Monica, California, USA.

Spine implant infections portend disastrous outcomes, as diagnosis is challenging and surgical eradication is at odds with mechanical spinal stability. Current imaging modalities can detect anatomical alterations and anomalies but cannot differentiate between infection and aseptic loosening, diagnose specific pathogens, or delineate the extent of an infection. Herein, a fully human monoclonal antibody 1D9, recognizing the immunodominant staphylococcal antigen A on the surface of Staphylococcus aureus, was assessed as a nuclear and fluorescent imaging probe in a preclinical model of S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.124813DOI Listing
February 2019

[Acute myeloid leukemia with sudden onset bilateral lower extremity paralysis caused by disseminated mucormycosis following unrelated bone marrow transplantation].

Rinsho Ketsueki 2019 ;60(1):17-21

Division of Hematology, Ehime Prefectural Central Hospital.

A 63-year-old woman was admitted to our hospital with relapsed acute myeloid leukemia. On day10 after reinduction therapy, she became febrile. Computed tomography on day15 revealed right upper lobe consolidation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11406/rinketsu.60.17DOI Listing
January 2019
1 Read

[Respiratory care in spinal muscular atrophy in the new therapeutic era].

Rev Chil Pediatr 2018 Dec;89(6):685-693

Programa Trastornos Motores y Enfermedades Neuromusculares, Clínica Las Condes, Chile.

Spinal muscular atrophy (SMA) is the first inherited cause of mortality in infants, with four subtypes: SMA0 prenatal onset, SMA1 babies less than 3 months non sitters, SMA2 sitters and SMA3 walkers. Pneumonia and respiratory insufficiency are the most severe complications. Informed parental de cisions are relevant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4067/S0370-41062018005001208DOI Listing
December 2018
1 Read

From Poly(Alkyl Cyanoacrylate) to Squalene as Core Material to Design Nanomedicines.

J Drug Target 2019 Feb 5:1-54. Epub 2019 Feb 5.

a Institut Galien Paris-Sud, UMR 8612, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue JB Clément , 92296 Châtenay-Malabry , France.

The present review article covers the most important steps of the pioneering work of Patrick Couvreur and tries to shed light on his outstanding career that has been a source of inspiration for many decades. His discovery of the biodegradable poly(alkyl cyanoacrylate) (PACA) nanoparticles has opened large perspectives in nanomedicine. Indeed, nanoparticles made from different types of PACA monomers have been used in different applications such as the treatment of intracellular infections or the treatment of multidrug resistant hepatocarcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1061186X.2019.1579822DOI Listing
February 2019
12 Reads

Low rates of complications after spinopelvic fixation with iliac screws in 260 adult patients with a minimum 2-year follow-up.

J Neurosurg Spine 2019 Feb 1:1-9. Epub 2019 Feb 1.

OBJECTIVERecent literature describing complications associated with spinopelvic fixation with iliac screws in adult patients has been limited but has suggested high complication rates. The authors' objective was to report their experience with iliac screw fixation in a large series of patients with a 2-year minimum follow-up.METHODSOf 327 adult patients undergoing spinopelvic fixation with iliac screws at the authors' institution between 2010 and 2015, 260 met the study inclusion criteria (age ≥ 18 years, first-time iliac screw placement, and 2-year minimum follow-up). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.9.SPINE18239DOI Listing
February 2019
1 Read

C-reactive protein misdiagnoses delayed postoperative spinal implant infections in patients with low-virulent microorganisms.

Eur Spine J 2019 Feb 2. Epub 2019 Feb 2.

Spine Department, Center for Musculoskeletal Surgery, Charité University Medicine Berlin, Chariteplatz 1, 10117, Berlin, Germany.

Purpose: C-reactive protein (CRP) has been shown to be a powerful parameter for detecting acute postoperative spinal implant infections (PSII) with a high sensitivity and specificity. However, little data are available on the performance of CRP in the diagnosis of delayed PSII. The aim of the current study was therefore to establish cutoff values for diagnosing delayed infection based on serum CRP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00586-019-05889-3DOI Listing
February 2019

Added value of [18F]fluorodeoxyglucose positron emission tomography/computed tomography for the diagnosis of post-operative instrumented spine infection.

Joint Bone Spine 2019 Jan 31. Epub 2019 Jan 31.

Department of Infectious and Tropical Diseases, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France; Centre de Référence Infections Ostéo-Articulaires Complexes du Grand Sud-Ouest (Crioac GSO), 33076 Bordeaux, France; INSERM U1219 Bordeaux Population Health, ISPED, University of Bordeaux, 33076 Bordeaux, France. Electronic address:

Purpose: Post-operative instrumented spine infection (PISI) is an infrequent complication. Diagnosis of spinal implant infection can be difficult, especially in case of chronic infection.

Methods: This retrospective study attempts to evaluate the diagnostic performance of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in PISI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2019.01.009DOI Listing
January 2019

Imaging of Acute Low Back Pain.

Radiol Clin North Am 2019 Mar 5;57(2):397-413. Epub 2018 Dec 5.

Department of Radiology and Imaging Sciences, University of Utah, 30 North 1900 East, Room 1A71, Salt Lake City, UT 84132, USA. Electronic address:

Acute low back pain, defined as less than 6 weeks in duration, does not require imaging in the absence of "red flags" that may indicate a cause, such as fracture, infection, or malignancy. When imaging is indicated, it is important to rule out a host of abnormalities that may be responsible for the pain and any associated symptoms. A common mnemonic VINDICATE can help ensure a thorough consideration of the possible causes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rcl.2018.10.001DOI Listing
March 2019
1 Read

Infection Prevention Considerations for Complex Penile Prosthesis Recipients.

Curr Urol Rep 2019 Feb 1;20(3):12. Epub 2019 Feb 1.

Section of Urology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Purpose Of Review: The purpose of this review is to critically analyze and summarize recent studies in the area of penile prosthesis surgery outcomes with a focus on infection prevention in high-risk patients.

Recent Findings: Reduction of surgical time in complex prosthesis surgery may reduce infection risk. Concomitant implant surgery is not associated with increased infection risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11934-019-0875-7DOI Listing
February 2019
1 Read

A rare cause of progressive neuropathy: Arachnoiditis ossificans.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):114-116

Department of Neurosurgery, PGIMER, Dr. R.M.L Hospital, New Delhi, India.

Arachnoiditis ossificans (AO) is a rare type of chronic arachnoiditis characterized by the presence of calcification or ossification of the spinal arachnoid which is usually associated with progressive neurological deficits. It is usually followed by prior history of trauma, surgery, infection, or myelography. Magnetic resonance imaging and computed tomography are the characteristics that are helpful in the diagnosis of most cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_403_17DOI Listing
February 2019
0.642 Impact Factor

Maternal short-term complications after planned cesarean delivery without medical indication: a register based study.

Acta Obstet Gynecol Scand 2019 Jan 30. Epub 2019 Jan 30.

Department of Gynecology and Obstetrics, Holbaek Hospital, Holbaek, Denmark.

Introduction: To compare short-term maternal outcomes in healthy primiparous women with uncomplicated pregnancies who delivered a singleton child in term by planned cesarean or planned vaginal delivery.

Material And Methods: Nationwide population-based cohort study of 145 821 low-risk primiparous women with healthy singletons in cephalic position in Denmark, 2008-2016. Data from the Medical Birth Register and the Danish National Patient Registry were linked and compared according to planned mode of delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aogs.13549DOI Listing
January 2019
3 Reads

Recurrent Encephalopathy with Spinal Cord Involvement: An Atypical Manifestation of Aicardi-Goutières Syndrome.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):111-115

Division of Neuroradiology and Pediatric Radiology, University of Arkansas For Medical Sciences, Little Rock, Arkansas, USA.

Aicardi-Goutières syndrome (AGS) is a rare, genetic inflammatory disease due to mutations in any of the seven genes discovered to date (, and ). Clinical onset is seen most commonly or in infancy; irritability, feeding difficulties, jitteriness, microcephaly, abnormal movements, seizures, bone marrow suppression, and liver dysfunction are seen either during the neonatal age group or within the first few months of life with abrupt onset of neurologic regression and slowing of head growth. Diffusely abnormal white matters with swelling of frontal or temporal lobes, cerebral atrophy, and intracranial calcification are typical neuroradiologic abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_12_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327704PMC
January 2019
2 Reads

The Efficacy of Computed Tomography-Guided Percutaneous Spine Biopsies in Determining a Causative Organism in Cases of Suspected Infection: A Systematic Review.

Can Assoc Radiol J 2019 Feb;70(1):96-103

Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: In suspected spondylodiscitis and vertebral osteomyelitis, computed tomography (CT)-guided biopsies are often performed to determine a causative organism and guide antimicrobial therapy. The aim of this study is to determine the diagnostic culture yield of CT-guided biopsies performed in cases of suspected spinal infections.

Methods: A literature search of PubMed and MEDLINE up to April 2017 was performed for keywords "CT guided vertebral biopsy infection," "CT-guided spine biopsy infection," "CT guided spine biopsy yield," and "CT guided vertebral biopsy yield. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carj.2018.09.003DOI Listing
February 2019

Surgical Treatment With Thoracic Pedicle Screw Fixation of Vertebral Osteomyelitis With Long-Term Follow-up.

Oper Neurosurg (Hagerstown) 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: While recent data has demonstrated the utility of lumbar pedicle screws for the treatment of vertebral osteomyelitis, the data are limited for thoracic pedicle screws.

Objective: To investigate the effectiveness of thoracic pedicle screws for the surgical treatment of vertebral osteomyelitis.

Methods: A retrospective review of all operations performed by 2 spinal neurosurgeons from 1999 to 2012 yielded 30 cases of vertebral osteomyelitis that were treated with thoracic pedicle screws. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ons/advance-article/doi/10.1093/ons
Publisher Site
http://dx.doi.org/10.1093/ons/opy398DOI Listing
January 2019
4 Reads

Sciatic Nerve Palsy due to a Superior Gluteal Artery Pseudoaneurysm PostBone Marrow Biopsy: A Case Report and Review of the Literature.

J Orthop Case Rep 2018 Jul-Aug;8(4):74-77

Department of Radiology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Greece.

Introduction: Sciatic nerve radiculopathy can present as a result of intraspinal or extraspinal causes. Intraspinal disorders can be disk hernia, spinal trauma, tumors, or infection, whereas extraspinal cause representsa disorder outside the lumbar spine. A gluteal artery (GA)false aneurysm can potentially compress the sciatic nerve and causes radiculopathy, with subsequent motor and sensory deficits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13107/jocr.2250-0685.1168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343557PMC
January 2019
1 Read

Community Acquired Stenotrophomonas maltophilia Discitis: Diagnosis Aided by Shotgun Metagenomic Sequencing.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, China; Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA, USA. Electronic address:

We report a rare case of culture negative L4-L5 discitis and epidural abscess in an immunocompetent child who had dry cupping therapy performed to treat low back strain. The causative pathogen was identified as Stenotrophomonas maltophilia by shotgun metagenomic sequencing of spinal cord aspirate after more than one month of unsuccessful empirical treatment with 6 different antibiotics. The patient was successfully treated with Sulfamethoxazole-trimethoprim and minocycline. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12019712193004
Publisher Site
http://dx.doi.org/10.1016/j.ijid.2019.01.032DOI Listing
January 2019
5 Reads

Identification of human herpesvirus 7 in the cerebrospinal fluid of adult ukrainian with relapsing-remitting multiple sclerosis. A case study.

Wiad Lek 2018 ;71(8):1636-1638

Sumy State University, Sumy, Ukraine.

Objective: Introduction: In this study, we investigated the possible involvement of Human herpesvirus 7 in multiple sclerosis. The aim: To contribute to clarifying the controversy on the association between Human Herpesviruses 7 (HHV-7) and multiple sclerosis (MS) studying patient with relapsing-remitting MS (RRMS).

Patients And Methods: Case study: Young female admitted to adult tertiary referral, infectious diseases hospital, Kyiv, Ukraine, with signs of a focal neurological deficit. Read More

View Article

Download full-text PDF

Source
January 2018

coenurosis in Tanzania: a major and under-recognised livestock disease problem in pastoral communities.

Vet Rec 2019 Feb 25;184(6):191. Epub 2019 Jan 25.

Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

A neurological syndrome of small ruminants, known locally as '', has been reported among pastoralist livestock keepers in Tanzania. This study was carried out in four affected pastoral communities to determine the prevalence and associated risk factors, characterise the clinical signs and investigate the aetiology of the syndrome. Questionnaires were administered at all households (n=480) within four study villages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/vr.105186DOI Listing
February 2019

Acute flaccid myelitis: Case report.

MSMR 2019 Jan;26(1):17-19

In August 2018, the U.S. Centers for Disease Control and Prevention (CDC) noted an increased number of reports of patients in the U. Read More

View Article

Download full-text PDF

Source
January 2019

Hospital based care at home; study protocol for a mixed epidemiological and randomized controlled trial.

Trials 2019 Jan 24;20(1):77. Epub 2019 Jan 24.

Department of Neurology, Haukeland University Hospital, Jonas Lies vei 71, 5053, Bergen, Norway.

Background: Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated, involving different specialties and with need for long-lasting follow-up. This study should identify risk factors for PU after SCI, and find an effective and less time-consuming treatment for the condition among different available methods for follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3185-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346520PMC
January 2019
2 Reads

Varicella zoster virus reactivation antedating ipsilateral brainstem stroke.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena.

itor Title: Varicella zoster virus reactivation antedating ipsilateral brainstem stroke Authors: Giuliana Galassi1, Maurilio Genovese2, Marisa Meacci3, Marcella Malagoli2 Affiliations: 1Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Italy, 2Neuroradiology Service, University Hospital of Modena, Italy, 3Department of Laboratory Medicine and Patholgy, Microbiology and Virology Unit, University Hospital of Modena, Italy Corresponding Author: Giuliana Galassi, MD, Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Via P. Giardini 1455, Modena, Italy, Tel: 39-3497325802, Email: giulianagalassi46@gmail.com Abstract: Varicella zoster virus (VZV) infection and reactivation are associated with a number of neurologic conditions. Read More

View Article

Download full-text PDF

Source
August 2018
1 Read

Modified Gant-Miwa-Thiersch procedure (mucosal plication with anal encircling) for rectal prolapse.

Colorectal Dis 2019 Jan 23. Epub 2019 Jan 23.

Coloproctology Center, Jihoukai Tanaka Hospital, Fukui, Japan.

Aim: Rectal prolapse (RP) is usually associated with elderly women and is well recognized as having a detrimental effect on quality of life. A number of surgical procedures for RP are available, but morbidity and mortality are substantial. The Gant-Miwa-Thiersch procedure (GMT) has been frequently used for RP in Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/codi.14565DOI Listing
January 2019

Acute flaccid myelitis caused by enterovirus D68: Case definitions for use in clinical practice.

Eur J Paediatr Neurol 2019 Jan 11. Epub 2019 Jan 11.

Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, UK; Child Life and Health, University of Edinburgh, Edinburgh, UK.

Acute flaccid myelitis (AFM) was increasingly detected in recent years, coinciding with upsurges of enterovirus D68 (EV-D68) infections. We reviewed the evidence for a causal relationship between both. Based on reported cases, we provide case definitions for AFM caused by EV-D68 infections to enable a standard procedure for affected patients. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10903798183028
Publisher Site
http://dx.doi.org/10.1016/j.ejpn.2019.01.001DOI Listing
January 2019
5 Reads

Facets of Theiler's Murine Encephalomyelitis Virus-Induced Diseases: An Update.

Int J Mol Sci 2019 Jan 21;20(2). Epub 2019 Jan 21.

Department of Pathology, University of Veterinary Medicine, Bünteweg 17, 30559 Hannover, Germany.

Theiler's murine encephalomyelitis virus (TMEV), a naturally occurring, enteric pathogen of mice is a Cardiovirus of the Picornaviridae family. Low neurovirulent TMEV strains such as BeAn cause a severe demyelinating disease in susceptible mice following intracerebral infection. Furthermore, TMEV infections of mice cause acute polioencephalitis initiating a process of epileptogenesis that results in spontaneous recurrent epileptic seizures in approximately 50% of affected mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20020448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358740PMC
January 2019
3 Reads