31,164 results match your criteria Spinal Infections

Effects of the COVID-19 Pandemic on Spinal Fusion Procedures for Spinal Infections in a Nationwide Hospital Network in Germany.

J Neurol Surg A Cent Eur Neurosurg 2022 Jun 27. Epub 2022 Jun 27.

Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Bad Saarow, Germany.

Background:  The full impact of the COVID-19 pandemic on surgical spine care is difficult to assess due to a lack in nationwide evidence from more recent phases of the pandemic. We aimed to describe changes in in-hospital processes associated with spinal fusion procedures in the treatment of spinal infections (SI) during different phases of the pandemic.

Methods:  In this retrospective observational study, we examined the in-hospital prevalence and outcomes of spinal fusion procedures for SI (along with patient characteristics, rates of transfer to intensive care units, and mortality rates) during the first four waves of the pandemic compared with the corresponding prepandemic periods in 2019. Read More

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Photosensitizer-Polypeptide Conjugate for Effective Elimination of Candida albicans Biofilm.

Adv Healthc Mater 2022 Jun 27:e2200268. Epub 2022 Jun 27.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

Persistent fungal infections caused by biofilms seriously endanger human health. In this study, a photosensitizer-polypeptide conjugate (PPa-cP) comprising a photosensitizer, pyropheophorbide a (PPa), and a cationic polypeptide (cP) was readily synthesized for effective antifungal and antibiofilm treatment. Compared with free PPa, the cationic PPa-cP showed enhanced binding ability to the negatively charged surface of Candida albicans (C. Read More

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Lumbar spinal stenosis - surgical outcome and the odds of revision-surgery: Is it all due to the surgeon?

Carolin Melcher

Technol Health Care 2022 Jun 10. Epub 2022 Jun 10.

Background: Surgical decompression is the intervention of choice for lumbar spinal stenosis (LSS) when non-operative treatment has failed. Apart from acute complications such as hematoma and infections, same-level recurrent lumbar stenosis and adjacent-segment disease (ASD) are factors that can occur after index lumbar spine surgery.

Objective: The aim of this retrospective case series was to evaluate the outcome of surgery and the odds of necessary revisions. Read More

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Vancomycin Use in Posterior Lumbar Interbody Fusion of Deep Surgical Site Infection.

Infect Drug Resist 2022 17;15:3103-3109. Epub 2022 Jun 17.

Department of Spinal Surgery, First Affiliated Hospital of Dali University, Dali, Yunnan, People's Republic of China.

Objective: To retrospectively analyze if the use of topical intraoperative vancomycin powder reduces deep surgical site infection (DSSI) after posterior lumbar interbody fusion.

Methods: All spinal surgeries for lumbar degenerative disease and underwent posterior fixation interbody fusion between January 2013 and December 2018 were reviewed. A total of 891 patients were included, of which 527 patients (treatment group) received intraoperatively topical vancomycin powder; the others were served as control group. Read More

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A Novel Construct to Treat Destructive Osteomyelitis of the Lumbar Spine in a Patient With Pre-existing Paraplegia.

Cureus 2022 May 20;14(5):e25162. Epub 2022 May 20.

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA.

Treatment for vertebral osteomyelitis varies depending on the extent of pathology and includes both medical and surgical approaches. Pathogen-directed antibiotic therapy is often the first-line treatment, however, refractory cases or those with sepsis, segmental instability, or epidural abscess may be candidates for surgical treatment. Patients with extensive bony destruction often require a corpectomy with the placement of a cage for anterior column reconstruction. Read More

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Clinical Features and Outcome of Multidrug-Resistant Osteoarticular Tuberculosis: A 12-Year Case Series from France.

Microorganisms 2022 Jun 14;10(6). Epub 2022 Jun 14.

Centre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses Croix Saint-Simon, 75020 Paris, France.

The optimal treatment for osteoarticular infection due to multidrug-resistant tuberculosis strains (MDR-OATB) remains unclear. This study aims to evaluate the diagnosis, management and outcome of MDR-OATB in France. We present a case series of MDR-OATB patients reviewed at the French National Reference Center for Mycobacteria between 2007 and 2018. Read More

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Minimally Invasive Spine Stabilization for Pyogenic Spondylodiscitis: A 23-Case Series and Review of Literature.

Medicina (Kaunas) 2022 Jun 1;58(6). Epub 2022 Jun 1.

Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), Narita 286-0048, Japan.

The incidence of pyogenic spondylodiscitis has been increasing due to the aging of the population. Although surgical treatment is performed for refractory pyogenic spondylodiscitis, surgical invasiveness should be considered. Recent minimally invasive spine stabilization (MISt) using percutaneous pedicle screw (PPS) can be a less invasive approach. Read More

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Neurogenic Bladder Physiology, Pathogenesis, and Management after Spinal Cord Injury.

J Pers Med 2022 Jun 14;12(6). Epub 2022 Jun 14.

Department of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Urinary incontinence is common after spinal cord injury (SCI) due to loss of supraspinal coordination and unabated reflexes in both autonomic and somatic nervous systems; if unchecked, these disturbances can become life-threatening. This manuscript will review normal anatomy and physiology of the urinary system and discuss pathophysiology secondary to SCI. This includes a discussion of autonomic dysreflexia, as well as its diagnosis and management. Read More

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How to Prevent Catheter-Associated Urinary Tract Infections: A Reappraisal of Vico's Theory-Is History Repeating Itself?

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Unit of Urological Robotic Surgery and Renal Transplantation, Azienda Ospedaliera Careggi, 50134 Florence, Italy.

New, contextualized modern solutions must be found to solve the dilemma of catheter-associated urinary infection (CAUTI) in long-term care settings. In this paper, we describe the etiology, risk factors, and complications of CAUTI, explore different preventive strategies proposed in literature from the past to the present, and offer new insights on therapeutic opportunities. A care bundle to prevent CAUTI mainly consists of multiple interventions to improve clinical indications, identifying a timeline for catheter removal, or whether any alternatives may be offered in elderly and frail patients suffering from chronic urinary retention and/or untreatable urinary incontinence. Read More

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Surgical Management of Spinal Tuberculosis-The Past, Present, and Future.

Diagnostics (Basel) 2022 May 24;12(6). Epub 2022 May 24.

Department of Orthopaedic Surgery, Jaslok Hospital and Research Centre, Mumbai 400026, India.

Tuberculosis is endemic in many parts of the world. With increasing immigration, we can state that it is prevalent throughout the globe. Tuberculosis of the spine is the most common form of bone and joint tuberculosis; the principles of treatment are different; biology, mechanics, and neurology are affected. Read More

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Loss to long-term follow-up in children with spinal tuberculosis: a retrospective cohort study at a tertiary hospital in the Western Cape, South Africa.

Pan Afr Med J 2022 23;41:241. Epub 2022 Mar 23.

Division of Orthopaedic Surgery, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, Cape Town, 7505, South Africa.

Introduction: children with spinal tuberculosis (TB) are at risk of kyphotic deformity both during and after the active phase of the disease. Management guidelines include follow-up until skeletal maturity. Little is known about adherence to this recommendation. Read More

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Predicting Surgical Site Infection Risk after Spinal Tuberculosis Surgery: Development and Validation of a Nomogram.

Surg Infect (Larchmt) 2022 Jun 20. Epub 2022 Jun 20.

Spine and Osteopathy Ward, Guangxi Medical University First Affiliated Hospital, Nanning, Guangxi Province, China.

The purpose of this study was to predict the surgical site infection risk after spinal tuberculosis surgery based on a nomogram. We collected the clinical data of patients who underwent spinal tuberculosis surgery in our hospital and included all the data in the least absolute shrinkage and selection operator (LASSO) regression analysis. Next, the selected parameters were analyzed using logistic regression. Read More

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Mechanism of COVID-19-Related Proteins in Spinal Tuberculosis: Immune Dysregulation.

Front Immunol 2022 2;13:882651. Epub 2022 Jun 2.

Spine and Osteopathy Ward, Guangxi Medical University First Affiliated Hospital, Nanning, China.

Purpose: The purpose of this article was to investigate the mechanism of immune dysregulation of COVID-19-related proteins in spinal tuberculosis (STB).

Methods: Clinical data were collected to construct a nomogram model. C-index, calibration curve, ROC curve, and DCA curve were used to assess the predictive ability and accuracy of the model. Read More

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Neurological and Psychological Characteristics of Young Nitrous Oxide Abusers and Its Underlying Causes During the COVID-19 Lockdown.

Front Public Health 2022 2;10:854977. Epub 2022 Jun 2.

Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.

Background: The COVID-19 pandemic has a serious impact on the mental health of the public due to its economic and social impact. And psychological effects have led to drug and alcohol abuse. After the city lifted the lockdown, we consecutively encountered several young nitrous oxide abusers admitted to hospital for neurological treatment. Read More

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A comparison of three bone graft struts for interbody fusion using a posterior approach for lower lumbar spinal tuberculosis in adults: a midterm follow-up study.

BMC Musculoskelet Disord 2022 Jun 18;23(1):590. Epub 2022 Jun 18.

Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, 87# Xiangya Road, Changsha, Hunan, 410008, People's Republic of China.

Background: This retrospective observational study was conducted to compare midterm outcomes of three bone graft struts for interbody fusion using a posterior approach in adults with lower lumbar spinal tuberculosis.

Methods: A total of 126 lower lumbar spinal tuberculosis patients were treated by one-stage posterior debridement, interbody fusion, and instrumentation. Forty-one patients (group A) were treated with autogenous bone graft for interbody fusion, 45 patients (group B) were treated with allogeneic bone grafting, and the remaining 40 (group C) patients were treated with titanium mesh cage. Read More

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Comparative efficacy of traditional conservative treatment and CT-guided local chemotherapy for mild spinal tuberculosis.

BMC Musculoskelet Disord 2022 Jun 18;23(1):589. Epub 2022 Jun 18.

Department of Orthopaedics, Zhoukou Orthopedic Hospital, Eastern Taihao Road, Zhoukou City, Henan Province, China.

Background: There are considerable differences in the treatment strategy for spinal tuberculosis, including conservative or surgical procedures. Conservative treatment is always suitable for most patients. This study aimed to compare the clinical efficacy of traditional conservative treatment with CT-guided local chemotherapy strategy of mild spinal tuberculosis. Read More

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Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler's murine encephalomyelitis.

PLoS One 2022 17;17(6):e0270239. Epub 2022 Jun 17.

Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.

Astrocytes produce extracellular matrix (ECM) glycoproteins contributing to the blood-brain barrier and regulating the immune response in the central nervous system (CNS). The aim of this study was to investigate the impact of astrocyte depletion upon the clinical outcome and the composition of ECM glycoproteins in a virus-induced animal model of demyelination. Glial fibrillary acidic protein (GFAP)-thymidine-kinase transgenic SJL (GFAP-knockout) and wildtype mice were infected with Theiler's murine encephalomyelitis virus (TMEV). Read More

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Effects of self-quarantine during the COVID-19 pandemic on patients with lumbar spinal stenosis: A case-control study.

Medicine (Baltimore) 2022 Jun 17;101(24):e29388. Epub 2022 Jun 17.

Department of Orthopedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.

Abstract: Prospective case-control studyThis study aimed to investigate the effect of self-quarantine on the changes in low back symptoms and activities of daily living (ADL) due to low physical activity because of the COVID-19 pandemic in patients with lumbar spinal stenosis (LSS).The frequency and intensity of low back and leg pain have reportedly increased in healthy subjects because of self-quarantine.Patients with LSS who self-quarantined from baseline (SQ group) were matched to controls who did not self-quarantine (non-SQ group), based on age, sex, medication, ADL, and the numeric rating scale score for low back symptoms. Read More

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Clinical differences between delayed and acute onset postoperative spinal infection.

Medicine (Baltimore) 2022 Jun 17;101(24):e29366. Epub 2022 Jun 17.

Department of Orthopaedic Surgery, Soonchunhyang University College of Medicine, Seoul, Korea.

Abstract: Spine surgeons often encounter cases of delayed postoperative spinal infection (PSI). Delayed-onset PSI is a common clinical problem. However, since many studies have investigated acute PSIs, reports of delayed PSI are rare. Read More

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Reduction of Instrumentation-Related Spine Surgical Site Infections After Optimization of Surgical Techniques. A Single Center Retrospective Analysis.

Global Spine J 2022 Jun 17:21925682221109557. Epub 2022 Jun 17.

Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University of Madrid, Madrid, Spain.

Study Design: Retrospective cohort study.

Objective: Although surgical risk factors for developing spine surgical site infections (S-SSI) have been identified, the impact of such knowledge in its prevention has not been demonstrated.

Methods: We evaluated in 500 patients undergoing spine surgery between 2011 and 2019 at Hospital 12 de Octubre the changes in S-SSI rates over time. Read More

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Diffuse Neurobrucellosis of Cerebellum, Brainstem, Spinal Cord, and Cauda Equina: A case report and Literature review.

J Radiol Case Rep 2022 May 1;16(5):1-9. Epub 2022 May 1.

Department of Radiology, Advanced diagnostic and interventional radiology research center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Neurobrucellosis is an uncommon serious complication of brucellosis. Diagnosis of neurobrucellosis could be difficult due to non-specific clinical and radiological findings. So, in endemic regions, neurobrucellosis should be included in the differential diagnosis list of patients with recent neurological disorders. Read More

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Characterization of Zymosan-Modulated Neutrophils With Neuroregenerative Properties.

Front Immunol 2022 30;13:912193. Epub 2022 May 30.

Department of Neurology, Ohio State Medical Center, Columbus, OH, United States.

Recent studies using advanced techniques such as single cell RNA sequencing (scRNAseq), high parameter flow cytometry, and proteomics reveal that neutrophils are more heterogeneous than previously appreciated. Unique subsets have been identified in the context of bacterial and parasitic infections, cancer, and tissue injury and repair. The characteristics of infiltrating neutrophils differ depending on the nature of the inflammation-inciting stimulus, the stage of the inflammatory response, as well as the tissue microenvironment in which they accumulate. Read More

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How Should Anesthesiologists Face Coronavirus Disease 2019?

Front Cardiovasc Med 2022 27;9:890967. Epub 2022 May 27.

Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.

Coronavirus disease 2019 (COVID-19) is a highly contagious disease. Most infected patients manifest mild flu-like symptoms, but in some cases, the patients rapidly develop severe lung infections and pneumonia. It is estimated that about 15-20% of patients with COVID-19 develop hypoxemia and require some form of oxygen therapy and ventilation support. Read More

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Long-term Radiological and Clinical Outcome after Lumbar Spinal Fusion Surgery in Patients with Degenerative Spondylolisthesis: A Prospective 6-Year Follow-up Study.

Orthop Surg 2022 Jun 16. Epub 2022 Jun 16.

University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Orthopedics and Trauma Surgery, Cologne, Germany.

Objective: To assess which radiological alignment parameters are associated with a satisfactory long-term clinical outcome after performing lumbar spinal fusion for treating degenerative spondylolisthesis.

Methods: This single-center prospective study assessed the relation between radiological alignment parameters measured on standing lateral lumbar spine radiographs and the patient-reported outcome using four different questionnaires (COMI, EQ-5D, ODI and VAS) as primary outcome measures (level of evidence: II). The following spinopelvic alignment parameters were used: gliding angle, sacral inclination, anterior displacement, sagittal rotation, lumbar lordosis, sacral slope, pelvic tilt and pelvic incidence. Read More

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Bacteroides fragilis Bacteremia Complicated by Spondylodiscitis, Spinal Epidural Abscess, and Sepsis: A Case Report.

Am J Case Rep 2022 Jun 16;23:e936179. Epub 2022 Jun 16.

Department of Orthopaedic and Spine Surgery, Evangelismos Hospital, Paphos, Cyprus.

BACKGROUND Pyogenic spondylitis comprises several clinical entities, including native vertebral osteomyelitis, septic discitis, pyogenic spondylodiscitis, and epidural abscess. The lumbar spine is most often infected, followed by the thoracic and cervical areas. It mainly develops (i) after spine surgery; (ii) from history of blunt trauma to the spinal column; (iii) from infections in adjacent structures (such as soft tissues); (iv) from iatrogenic inoculation after invasive procedures (such as lumbar puncture); and (v) from hematogenous bacterial spread to the vertebra (mainly through the venous route). Read More

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Chronic nonbacterial osteomyelitis in children: a multicentre Belgian cohort of 30 children.

Pediatr Rheumatol Online J 2022 Jun 13;20(1):41. Epub 2022 Jun 13.

Department of Paediatrics, Paediatric Rheumatology and Immune-Inflammatory Diseases, Leuven University Hospitals, Herestraat 49, 3000, Leuven, Belgium.

Background: To evaluate clinical characteristics, imaging findings, therapeutic approach and outcome of paediatric patients with Chronic Non-Bacterial Osteomyelitis (CNO).

Methods: Retrospective review of 30 children diagnosed with CNO at two tertiary care centres in Belgium. Imaging data were evaluated by blinded paediatric radiologists. Read More

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Family-centred care for children with traumatic brain injury and/or spinal cord injury: a qualitative study of service provider perspectives during the COVID-19 pandemic.

BMJ Open 2022 Jun 13;12(6):e059534. Epub 2022 Jun 13.

Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia

Objectives: COVID-19 has led to rapid changes in rehabilitation service provision for young people living with traumatic brain and/or spinal cord injury. The aim of this project was to understand the experiences of rehabilitation service providers during the acute response stage of the COVID-19 pandemic. Specifically, we aimed to identify innovative approaches to meeting the ongoing needs of young people with traumatic brain and/or spinal cord injury during this time. Read More

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Spinal Cord Injury Impairs Lung Immunity in Mice.

J Immunol 2022 Jun 13. Epub 2022 Jun 13.

Department of Neuroscience, The Ohio State University, Columbus, OH;

Pulmonary infection is a leading cause of morbidity and mortality after spinal cord injury (SCI). Although SCI causes atrophy and dysfunction in primary and secondary lymphoid tissues with a corresponding decrease in the number and function of circulating leukocytes, it is unknown whether this SCI-dependent systemic immune suppression also affects the unique tissue-specific antimicrobial defense mechanisms that protect the lung. In this study, we tested the hypothesis that SCI directly impairs pulmonary immunity and subsequently increases the risk for developing pneumonia. Read More

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Sepsis-associated neuroinflammation in the spinal cord.

PLoS One 2022 13;17(6):e0269924. Epub 2022 Jun 13.

Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan.

Septic patients commonly present with central nervous system (CNS) disorders including impaired consciousness and delirium. Today, the main mechanism regulating sepsis-induced cerebral disorders is believed to be neuroinflammation. However, it is unknown how another component of the CNS, the spinal cord, is influenced during sepsis. Read More

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Impact of the Covid-19 Pandemic on Delivery of Acute and Post-Acute Care to Patients with Newly Diagnosed Traumatic Spinal Cord Injury.

M Boland E Smith

Ir Med J 2022 Apr 29;115(4):583. Epub 2022 Apr 29.

National Rehabilitation Hospital, Rochestown Avenue, Dun Laoghaire, Co. Dublin, Ireland.

Aim To investigate the impact of the first wave of the Covid-19 pandemic on the care of patients with newly acquired traumatic spinal cord injury (TSCI) in Ireland Methods A prospective audit of patients with newly acquired TSCI from 1st March to 30th June 2020 was undertaken. Cases were drawn from referrals received through the National Spinal Injuries Unit (NSIU) and neurosciences centres. The standard of care guidelines used were from National Health Service (NHS) England standards, the Irish Integrated Care Pathway and British Association of Spinal cord Injury Specialist (BASCIS) COVID-19 guidelines. Read More

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